CN106074342B - Geraniol nanoparticle no-clean gel hand sanitizer and preparation method thereof - Google Patents
Geraniol nanoparticle no-clean gel hand sanitizer and preparation method thereof Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
- A61K2800/65—Characterized by the composition of the particulate/core
- A61K2800/652—The particulate/core comprising organic material
Abstract
The invention discloses a geraniol nanoparticle no-clean gel hand sanitizer, which comprises the following raw materials in percentage by weight: 0.6-1.0% of geraniol nanoparticles, 0.1-0.3% of carbomer, 0.05-0.09% of triethanolamine, 0.05-0.15% of 1, 2-propylene glycol, 0.05-0.15% of hydroxyethyl urea, 0.05-0.15% of sodium lactate, 0.05-0.15% of essence, 0.05-0.15% of edible pigment and the balance of distilled water. The invention also discloses a preparation method of the geraniol nanoparticle no-clean gel hand sanitizer. The hand sanitizer can continuously release the sterilization and bacteriostasis components, so that the hand sanitizer has broad-spectrum and high-efficiency sterilization effect, has good killing effect on escherichia coli and staphylococcus aureus, has good stability, does not irritate skin, and has the effects of moisturizing and protecting skin.
Description
Technical Field
The invention relates to the technical field of gel hand sanitizer, in particular to a geraniol nanoparticle no-clean gel hand sanitizer and a preparation method thereof.
Background
At present, the commonly used bactericide components at home and abroad are synthesized organic micromolecules, such as triclosan, chlorhexidine acetate and the like. Although these bactericides have a strong bactericidal effect, triclosan and the like are reported to have a carcinogenic risk, and especially, to be distorted in newborns. And the herbal plant extract is used as a disinfectant, so that the disinfectant is safer.
Disclosure of Invention
Based on the technical problems in the background art, the invention provides a geraniol nanoparticle no-clean gel hand sanitizer and a preparation method thereof, which continuously release sterilization and bacteriostasis components, so that the obtained hand sanitizer has a broad-spectrum and high-efficiency sterilization effect, has a good killing effect on escherichia coli and staphylococcus aureus, is good in stability, has no stimulation to skin, and has the effects of moisturizing and protecting skin.
The invention provides a geraniol nanoparticle no-clean gel hand sanitizer, which comprises the following raw materials in percentage by weight: 0.6-1.0% of geraniol nanoparticles, 0.1-0.3% of carbomer, 0.05-0.09% of triethanolamine, 0.05-0.15% of 1, 2-propylene glycol, 0.05-0.15% of hydroxyethyl urea, 0.05-0.15% of sodium lactate, 0.05-0.15% of essence, 0.05-0.15% of edible pigment and the balance of distilled water.
Preferably, the weight ratio of carbomer to triethanolamine to 1, 2-propanediol to hydroxyethyl urea to sodium lactate is 15-25: 6-8: 8-12: 8-12: 8 to 12.
Preferably, the traditional Chinese medicine composition further comprises a traditional Chinese medicine extract, and the weight ratio of the traditional Chinese medicine extract to the geraniol nanoparticles is 5-6: 7 to 9.
Preferably, the preparation method of the geraniol nanoparticles is as follows: adding geraniol and polyoxyethylene polyoxypropylene segmented copolymer into ethanol to be completely dissolved to obtain a mixed solution; and (3) the mixed solution is flushed with distilled water, then the mixed solution is kept stand, and ethanol is removed to obtain the geraniol nanoparticles.
Preferably, in the hedging process of the preparation method of the geraniol nanoparticles, the flow rate of the mixed solution is 4-6 mL/min, and the flow rate of the distilled water is 40-60 mL/min.
Preferably, in the preparation method of the geraniol nanoparticles, the mixed solution is flushed with distilled water and then is kept stand for 9-11 hours.
Preferably, the polyoxyethylene polyoxypropylene block copolymer is Pluronic F-127.
Preferably, the preparation method of the traditional Chinese medicine extract comprises the following steps: adding flos Lonicerae, fructus Gardeniae, flos Chrysanthemi, and Olibanum into water, boiling, keeping the temperature, and filtering to obtain filter residue and first filtrate; adding the filter residue into water, boiling, preserving heat, and filtering to obtain a second filtrate; mixing the first filtrate and the second filtrate, and concentrating to obtain an extract; mixing the extract and Mel to obtain Chinese medicinal extract.
Preferably, the preparation method of the traditional Chinese medicine extract comprises the following steps: adding 18-22 parts by weight of honeysuckle, 17-20 parts by weight of gardenia, 15-18 parts by weight of chrysanthemum and 23-26 parts by weight of frankincense into clear water, boiling, keeping the temperature for 1.5-2.5 hours, and filtering to obtain filter residue and filtrate a; adding the filter residue into clear water, boiling, preserving heat for 1.5-1.8 h, and filtering to obtain filtrate b; mixing the filtrate a and the filtrate b, and concentrating to obtain the traditional Chinese medicine extract.
The invention also provides the geraniol nanoparticle no-clean gel hand sanitizer, which is prepared by adding carbomer into distilled water, and continuously stirring the carbomer in the adding process until the carbomer is completely swelled; and adding 1, 2-propylene glycol, hydroxyethyl urea, sodium lactate, essence and pigment, stirring for 1h to be uniform, adding the geraniol nanoparticles, stirring for 0.5h, and adding triethanolamine to form gel to obtain the geraniol nanoparticle no-clean gel hand sanitizer.
According to the invention, geraniol which is a main component in rose essential oil is used as a bactericide, and nanoparticles are used for wrapping geraniol, so that the geraniol can be slowly released, and a lasting bactericidal effect is achieved; the hand sanitizer has a wide antibacterial spectrum, has a good effect of killing escherichia coli and staphylococcus aureus, has an effect of inhibiting dermatophytes, diphtheria bacillus, tubercle bacillus, vibrio cholerae, shigella dysenteriae and candida albicans, and also has an anti-influenza virus effect. Meanwhile, the extracts of the honeysuckle and the saffron are mutually matched, so that the skin care cream has no any harmful stimulation to the skin, can moisten the skin, enhance the skin nutrition, promote the skin blood circulation and effectively prevent the skin from dehydration, hardening and wrinkling, thereby keeping the moisture in the skin cuticle and enabling the skin to be tender, smooth and elastic. The 1, 2-propylene glycol, the hydroxyethyl urea and the sodium lactate can further promote the extracts of the honeysuckle and the saffron to permeate into the cuticle, increase the water content of the skin, relieve dryness, fill fine wrinkles and increase the skin elasticity. The invention adopts the mutual matching of the triethanolamine, the 1, 2-propylene glycol, the hydroxyethyl urea and the sodium lactate as the humectant and the antifreeze agent, and the carbomer and the triethanolamine as the thickening agent, so that the liquid soap obtained by the invention has stable performance, and can further protect the skin of a user from being dry and peeling after washing hands.
In conclusion, the hand sanitizer disclosed by the invention has a broad-spectrum and efficient sterilization effect, has a good killing effect on escherichia coli and staphylococcus aureus, is good in stability, does not irritate the skin, and has the effects of moisturizing and protecting the skin.
Drawings
FIG. 1 is a graph showing the effect of sustained release of geraniol nanoparticles obtained in example 3 of the present invention placed on a separation membrane.
Detailed Description
The technical solution of the present invention will be described in detail below with reference to specific examples.
Example 1
The invention provides a geraniol nanoparticle no-clean gel hand sanitizer, which comprises the following raw materials in percentage by weight: geraniol nano particles 0.6%, carbomer 0.3%, triethanolamine 0.05%, 1, 2-propylene glycol 0.15%, hydroxyethyl urea 0.05%, sodium lactate 0.15%, essence 0.05%, edible pigment 0.15%, and the balance of distilled water.
Example 2
The invention provides a geraniol nanoparticle no-clean gel hand sanitizer, which comprises the following raw materials in percentage by weight: geraniol nanoparticles 1.0%, carbomer 0.1%, triethanolamine 0.09%, 1, 2-propylene glycol 0.05%, hydroxyethyl urea 0.15%, sodium lactate 0.05%, essence 0.15%, edible pigment 0.05%, and the balance of distilled water.
The preparation method of the geraniol nanoparticles comprises the following steps: adding geraniol and polyoxyethylene polyoxypropylene segmented copolymer into ethanol to be completely dissolved to obtain a mixed solution; and (3) the mixed solution is flushed with distilled water, then the mixed solution is kept stand, and ethanol is removed to obtain the geraniol nanoparticles.
Example 3
The invention provides a geraniol nanoparticle no-clean gel hand sanitizer, which comprises the following raw materials in percentage by weight: geraniol nano particles 0.8%, carbomer 0.2%, triethanolamine 0.07%, 1, 2-propylene glycol 0.1%, hydroxyethyl urea 0.1%, sodium lactate 0.1%, essence 0.1%, edible pigment 0.1%, and the balance of distilled water.
The preparation method of the geraniol nanoparticles comprises the following steps: adding geraniol and Pluronic F-127 into ethanol to be completely dissolved to obtain a mixed solution; and (3) carrying out hedging on the mixed solution and distilled water, wherein in the hedging process, the flow rate of the mixed solution is 5mL/min, the flow rate of the distilled water is 50mL/min, then standing for 10h, and removing ethanol to obtain the geraniol nanoparticles.
The invention also provides the geraniol nanoparticle no-clean gel hand sanitizer, which is prepared by adding carbomer into distilled water, and continuously stirring the carbomer in the adding process until the carbomer is completely swelled; and adding 1, 2-propylene glycol, hydroxyethyl urea, sodium lactate, essence and pigment, stirring for 1h to be uniform, adding the geraniol nanoparticles, stirring for 0.5h, and adding triethanolamine to form gel to obtain the geraniol nanoparticle no-clean gel hand sanitizer.
Example 4
The invention provides a geraniol nanoparticle no-clean gel hand sanitizer, which comprises the following raw materials in percentage by weight: geraniol nano particles 0.7%, traditional Chinese medicine extract 0.6%, carbomer 0.15%, triethanolamine 0.08%, 1, 2-propylene glycol 0.08%, hydroxyethyl urea 0.12%, sodium lactate 0.08%, essence 0.12%, food color 0.08%, and the balance of distilled water.
The preparation method of the geraniol nanoparticles comprises the following steps: adding geraniol and Pluronic F-127 into ethanol to be completely dissolved to obtain a mixed solution; and (3) carrying out hedging on the mixed solution and distilled water, wherein in the hedging process, the flow rate of the mixed solution is 6mL/min, the flow rate of the distilled water is 40mL/min, then standing for 11h, and removing ethanol to obtain the geraniol nanoparticles.
The preparation method of the traditional Chinese medicine extract comprises the following steps: adding 18 parts by weight of honeysuckle, 20 parts by weight of gardenia, 15 parts by weight of chrysanthemum and 26 parts by weight of frankincense into clear water, boiling, preserving heat for 1.5 hours, and filtering to obtain filter residue and filtrate a; adding the filter residue into clear water, boiling, keeping the temperature for 1.8h, and filtering to obtain filtrate b; mixing the filtrate a and the filtrate b, and concentrating to obtain the traditional Chinese medicine extract.
Example 5
The invention provides a geraniol nanoparticle no-clean gel hand sanitizer, which comprises the following raw materials in percentage by weight: geraniol nano particles 0.9%, traditional Chinese medicine extract 0.5%, carbomer 0.25%, triethanolamine 0.06%, 1, 2-propylene glycol 0.12%, hydroxyethyl urea 0.08%, sodium lactate 0.12%, essence 0.08%, food color 0.12%, and the balance of distilled water.
The preparation method of the geraniol nanoparticles comprises the following steps: adding geraniol and Pluronic F-127 into ethanol to be completely dissolved to obtain a mixed solution; and (3) carrying out hedging on the mixed solution and distilled water, wherein in the hedging process, the flow rate of the mixed solution is 4mL/min, the flow rate of the distilled water is 60mL/min, then standing for 9h, and removing ethanol to obtain the geraniol nanoparticles.
The preparation method of the traditional Chinese medicine extract comprises the following steps: adding 22 parts by weight of honeysuckle, 17 parts by weight of gardenia, 18 parts by weight of chrysanthemum and 23 parts by weight of frankincense into clear water, boiling, preserving heat for 2.5 hours, and filtering to obtain filter residue and filtrate a; adding the filter residue into clear water, boiling, keeping the temperature for 1.5h, and filtering to obtain filtrate b; mixing the filtrate a and the filtrate b, and concentrating to obtain the traditional Chinese medicine extract.
The geraniol nanoparticles obtained in example 3 were subjected to performance tests:
I. 9mL of the geraniol nanoparticles obtained in example 3 were placed on a separation membrane with a 2nm membrane filter size that was insufficient for nanoparticles to pass through, but free geraniol molecules could penetrate the membrane. Placing a beaker filled with distilled water at the bottom of the membrane, detecting the geraniol content in the beaker in 1,2, 4, 8, 24, 48, 96 and 144 hours respectively, and obtaining data of nano-release geraniol as shown in figure 1.
II. The bacteriostatic and bactericidal effects of the geraniol nanoparticles obtained in example 3 and geraniol were compared, and the results are shown below:
from the above table, it can be seen that: the bacteriostasis and sterilization effects of the geraniol nanoparticles are better than those of salmonella.
The geraniol nanoparticle no-clean gel hand sanitizer obtained in example 3 was subjected to performance testing: respectively culturing Escherichia coli and Staphylococcus aureus in culture solution at 37 deg.C under shaking for 24 hr, and diluting the bacteria solution to bacterial concentration of 1 × 108CFU/mL, bacteria were spread evenly on agar plates. Then placing the round paper sheet soaked with 1mL of common washing-free hand sanitizer sold in the market in a culture dish as a control group; round paper sheets soaked with 1mL of the geraniol nanoparticle wash-free gel hand sanitizer obtained in example 3 of the present invention were placed in a culture dish to serve as an experimental group. The plate was then placed in an incubator at 37 ℃ for 24 h. The current culture results are as follows:
class of bacteria | Experiment group diameter of zone of inhibition (mm) | Control group zone diameter (mm) |
Escherichia coli | 23.2±0.36 | 13.8±0.16 |
Staphylococcus aureus | 15.6±0.17 | 11.6±0.18 |
Wherein, the diameter of the inhibition zone is less than 10mm and is considered to be inactive, the diameter of the inhibition zone is 10-14mm and is considered to have medium activity, the diameter of the inhibition zone is 14-19mm and is considered to be high activity, and the diameter of the inhibition zone is not less than 20mm and is considered to be very strong activity.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (8)
1. A geraniol nanoparticle no-clean gel hand sanitizer is characterized by comprising the following raw materials in percentage by weight: 0.6-1.0% of geraniol nanoparticles, 0.1-0.3% of carbomer, 0.05-0.09% of triethanolamine, 0.05-0.15% of 1, 2-propylene glycol, 0.05-0.15% of hydroxyethyl urea, 0.05-0.15% of sodium lactate, 0.05-0.15% of essence, 0.05-0.15% of edible pigment and the balance of distilled water;
the preparation method of the geraniol nanoparticles comprises the following steps: adding geraniol and polyoxyethylene polyoxypropylene segmented copolymer into ethanol to be completely dissolved to obtain a mixed solution; and (3) the mixed solution is flushed with distilled water, then the mixed solution is kept stand, and ethanol is removed to obtain the geraniol nanoparticles.
2. The geraniol nanoparticle no-clean gel hand sanitizer according to claim 1, wherein the weight ratio of carbomer, triethanolamine, 1, 2-propanediol, hydroxyethyl urea and sodium lactate is 15-25: 6-8: 8-12: 8-12: 8 to 12.
3. The geraniol nanoparticle wash-free gel hand sanitizer according to claim 1 or 2, further comprising a traditional Chinese medicine extract, wherein the weight ratio of the traditional Chinese medicine extract to the geraniol nanoparticles is 5-6: 7 to 9.
4. The geraniol nanoparticle wash-free gel hand sanitizer according to any one of claims 1 to 3, wherein in the hedging process of the preparation method of the geraniol nanoparticles, the flow rate of the mixed solution is 4-6 mL/min, and the flow rate of the distilled water is 40-60 mL/min.
5. The geraniol nanoparticle wash-free gel hand sanitizer according to any one of claims 1 to 3, wherein in the preparation method of the geraniol nanoparticles, the mixed solution is flushed with distilled water and then is kept still for 9-11 hours.
6. The geraniol nanoparticle wash-free gel hand sanitizer according to claim 3, wherein the preparation method of the traditional Chinese medicine extract comprises the following steps: adding flos Lonicerae, fructus Gardeniae, flos Chrysanthemi, and Olibanum into water, boiling, keeping the temperature, and filtering to obtain filter residue and first filtrate; adding the filter residue into water, boiling, preserving heat, and filtering to obtain a second filtrate; mixing the first filtrate and the second filtrate, and concentrating to obtain an extract; mixing the extract and Mel to obtain Chinese medicinal extract.
7. The geraniol nanoparticle wash-free gel hand sanitizer according to claim 3, wherein the preparation method of the traditional Chinese medicine extract comprises the following steps: adding 18-22 parts by weight of honeysuckle, 17-20 parts by weight of gardenia, 15-18 parts by weight of chrysanthemum and 23-26 parts by weight of frankincense into clear water, boiling, keeping the temperature for 1.5-2.5 hours, and filtering to obtain filter residue and filtrate a; adding the filter residue into clear water, boiling, preserving heat for 1.5-1.8 h, and filtering to obtain filtrate b; mixing the filtrate a and the filtrate b, and concentrating to obtain the traditional Chinese medicine extract.
8. A method for preparing the geraniol nanoparticle no-clean gel hand sanitizer according to claim 1, wherein carbomer is added into distilled water, and stirring is continuously carried out during the addition process until the carbomer is completely swelled; and adding 1, 2-propylene glycol, hydroxyethyl urea, sodium lactate, essence and pigment, stirring for 1h to be uniform, adding the geraniol nanoparticles, stirring for 0.5h, and adding triethanolamine to form gel to obtain the geraniol nanoparticle no-clean gel hand sanitizer.
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1244893A (en) * | 1996-11-13 | 2000-02-16 | 普罗格特-甘布尔公司 | Disinfecting microemulsions |
CN101076315A (en) * | 2004-11-17 | 2007-11-21 | 吉万奥丹股份有限公司 | Sterilization preparation |
CN103768007A (en) * | 2012-10-26 | 2014-05-07 | 杭州元祺生物科技有限公司 | Medical disinfecting gel |
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1244893A (en) * | 1996-11-13 | 2000-02-16 | 普罗格特-甘布尔公司 | Disinfecting microemulsions |
CN101076315A (en) * | 2004-11-17 | 2007-11-21 | 吉万奥丹股份有限公司 | Sterilization preparation |
CN103768007A (en) * | 2012-10-26 | 2014-05-07 | 杭州元祺生物科技有限公司 | Medical disinfecting gel |
Non-Patent Citations (1)
Title |
---|
Principles of nanoparticle formation by flash nanoprecipitation;Walid S.Saad等;《nanotoday》;20160503;第11卷;212-227 * |
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