CN104906185A - Chinese herbal medicine essential oil microcapsule and preparation method and application thereof - Google Patents
Chinese herbal medicine essential oil microcapsule and preparation method and application thereof Download PDFInfo
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- CN104906185A CN104906185A CN201510270173.XA CN201510270173A CN104906185A CN 104906185 A CN104906185 A CN 104906185A CN 201510270173 A CN201510270173 A CN 201510270173A CN 104906185 A CN104906185 A CN 104906185A
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Abstract
The invention discloses a Chinese herbal medicine essential oil microcapsule and a preparation method and application thereof. The preparation method includes the steps that a wall material composed of maltodextrin and isolated soybean protein is dissolved in water at the temperature of 70-80 DEG C, and a solution A is obtained; Chinese herbal medicine essential oil and an emulsifier are dissolved in water of 50-60 DEG C, and a solution B is obtained; the solution A and the solution B are mixed and stirred when hot, emulsion is obtained through high-pressure homogenization, and finally a Chinese herbal medicine essential oil microcapsule is prepared through the spraying and drying technology. According to the prepared microcapsule, through combination and mutual promotion between traditional Chinese medicine with an anti-bacterial and various kinds of traditional Chinese medicine, the anti-bacterial and sterilization functions are greatly enhanced, the method can be used for preparation of hand washing gel, and the microcapsule can achieve effective disinfection and sterilization, has no stimulation on skin and has no toxic and adverse effects.
Description
Technical field
The invention belongs to cosmetics of everyday use technical field, be specifically related to a kind of Chinese herbal medicine essential oil microcapsules and its preparation method and application.
Background technology
For a long time, kind for the cleaning compositions of people's routine hand and article surface is a lot, the kind of disposable hand wash composition also occurs commercially successively, but, existing product multiple use chemical composition carries out sterilizing or antibacterial, and using has certain zest afterwards to skin, and life-time service has potential threat to human body, make microorganism produce resistance to a certain degree to this kind of chemical composition simultaneously, reduce the effect that its hand is antibacterial.And really suit people's demand, not only environmental protection but also be conducive to health, and use safety, the health care product with antibacterial sterilization effect waits further exploitation, one is needed effectively to sterilize, again, the pure Chinese herbal antibacterial preparation that have no side effect non-stimulated to skin.
In the last few years, volatile oil became Chinese herbal medicine and was one of important composition.Prove through long-term pharmacology and clinic, traditional medicine volatile oil has multiple pharmacologically active, as: the effect such as antioxidation, antiinflammatory, antibacterial, sterilization, antiviral or parasite killing.But be easily vaporized under its room temperature, and oxidizable rotten, have impact on its application.
Microcapsule technology is a kind of a kind of resist technology adopting filmogen some to be had reactivity, sensitivity or volatile liquid or solid encapsulating formation fine particle; the process of encapsulating is micro encapsulation; the fine particle formed is called microcapsule; size is generally at 1 ~ 1000 μm, and the thickness of cyst wall is at 0.2 ~ 10 μm.The function of microcapsule mainly contains: one is the effect preventing or slow down the protection cores such as unstable core material volatilization, oxidation and corruption; Two is overcome some core material poor fluidities, not easily preserve, be inconvenient to the shortcoming of transporting; Three is bad smell or the taste of covering core material, is core material slow releasing etc. according to certain requirement.
By literature search, identical with the present invention open source literature report is had no.
Summary of the invention
The object of the present invention is to provide a kind of Chinese herbal medicine microcapsule and its preparation method and application.
The present invention adopts following technical scheme:
A. be that maltodextrin and the soybean protein isolate of 3:1 ~ 2 is dissolved in the water of 70 ~ 80 DEG C by wall material weight ratio, obtain solution A;
B. Chinese herbal medicine quintessence oil and emulsifying agent sucrose ester are dissolved in the water of 50 ~ 60 DEG C, obtain solution B;
C. solution A and solution B are mixed while hot, stir, obtain emulsion through high pressure homogenize, finally by spray drying technology, obtained Chinese herbal medicine essential oil microcapsules.
The percentage ratio that each amounts of components of Chinese herbal medicine quintessence oil described in step b accounts for all components weight is: Chinese herbal medicine quintessence oil 15 ~ 30%, emulsifying agent 1 ~ 2%, wall material 68 ~ 84%.
Chinese herbal medicine quintessence oil described in step b is the P-Cymene of weight ratio 1 ~ 3:1 ~ 3:2:2, Herba Achilleae quintessence oil, Herba Schizonepetae quintessence oil and Rhizoma Atractylodis quintessence oil.
Homogenization pressure described in step c is 20 ~ 30MPa, and temperature is 60 ~ 70 DEG C, and cycle-index is 1 ~ 3 time.
Spray drying condition described in step c is inlet temperature is 180 ~ 200 DEG C, and outlet temperature is 80 ~ 100 DEG C, and atomizing pressure is 0.2 ~ 0.5MPa.
2. the gel of washing one's hands containing above-mentioned microcapsule, this gel of washing one's hands is antibacterial, bactericidal effect is obvious.
(1) preparation method of gel of washing one's hands comprises the steps:
Under stirring condition, the hydrogel excipient Carbopol 941 of ion chelating agent EDTA, 500g of 100g and the said herbal medicine essential oil microcapsules of 200g are added in the deionized water of 2500kg, prepare solution I;
Be that 5:1 wetting agent glycerol and hyaluronic mixture are added in the ethanol of 95% of 60kg by 5kg mass ratio, obtain solution II;
Under the condition stirred and seal, mixed by solution I with solution II, the pH regulating mixed solution is 8, obtains the gel of washing one's hands containing Chinese herbal medicine essential oil microcapsules.
(2) bacteriostatic experiment
By comparing Chinese herbal medicine essential oil microcapsules and this bacteriostasis rate of gel to staphylococcus aureus (Staphylococcus aureus), escherichia coli (Escherichia coli), Salmonella (S.typhimuriym LT2), Pseudomonas aeruginosa (Pseudomonas aeruginosa) of washing one's hands, evaluate the inhibition of gel to malignant bacteria of washing one's hands.Adopt flat band method, on the nutrient agar containing variable concentrations antibacterial, after cultivating above-mentioned four kinds of bacterium 24h through 37 DEG C, detect its clump count.In this experiment, the bacterium colony concentration of four kinds of bacterium is 10
5cFU/mL.Do not add the flat board of any antibacterial in contrast.
Suppression ratio=(1-test group clump count/matched group clump count) × 100%
Table 1 is containing the suppression ratio of the gel of washing one's hands of Chinese herbal medicine essential oil microcapsules
Note: "-" indicates without antibacterial.
As can be seen from the table, this gel of washing one's hands all has fungistatic effect, wherein to staphylococcus aureus, escherichia coli, Salmonella fungistatic effect obviously, and slightly poor to the fungistatic effect of Pseudomonas aeruginosa.
Chinese herbal medicine essential oil microcapsules of the present invention, by the mutual compatibility between every Chinese medicine, the effect of mutually promoting, greatly strengthen its effect that is antibacterial, sterilization.Be applied to wash one's hands in gel, stronger suppression, elimination effect can be had on the one hand to antibacterial, simultaneously owing to using Chinese herbal medicine essential oil microcapsules to carry out sterilizing, sterilizing, avoid in prior art and use chemical substance sterilizing and infringement that health is caused.
Further illustrate the present invention below in conjunction with detailed description of the invention, but the scope of protection of present invention is not limited to following embodiments.
detailed description of the invention:
Embodiment 1:
Be that 68g maltodextrin and the soybean protein isolate of 3:1 is dissolved in the water of 70 DEG C by wall material weight ratio, obtain solution A; Be that 30g Chinese herbal medicine quintessence oil and the 2g emulsifying agent sucrose ester of 1:1:2:2 is dissolved in the water of 60 DEG C by mass ratio, obtain solution B; Solution A and solution B are mixed while hot, stir, in pressure be 30MPa, temperature is 70 DEG C, circulation homogenizing 3 times emulsion, finally in inlet temperature be 200 DEG C, outlet temperature is 100 DEG C, atomizing pressure be the condition of 0.5MPa under spraying dry, obtained Chinese herbal medicine essential oil microcapsules.
Embodiment 2:
Be that 84g maltodextrin and the soybean protein isolate of 3:2 is dissolved in the water of 80 DEG C by wall material weight ratio, obtain solution A; Be that 15g Chinese herbal medicine quintessence oil and the 1g emulsifying agent sucrose ester of 2:3:2:2 is dissolved in the water of 50 DEG C by mass ratio, obtain solution B; Solution A and solution B are mixed while hot, stir, in pressure be 20MPa, temperature is 60 DEG C, circulation homogenizing 2 times emulsion, finally in inlet temperature be 180 DEG C, outlet temperature is 80 DEG C, atomizing pressure be the condition of 0.2MPa under spraying dry, obtained Chinese herbal medicine essential oil microcapsules.
Embodiment 3:
Be that 75g maltodextrin and the soybean protein isolate of 3:1.5 is dissolved in the water of 75 DEG C by wall material weight ratio, obtain solution A; Be that 23.5g Chinese herbal medicine quintessence oil and the 1.5g emulsifying agent sucrose ester of 3:2:2:2 is dissolved in the water of 55 DEG C by mass ratio, obtain solution B; Solution A and solution B are mixed while hot, stir, in pressure be 25MPa, temperature is 65 DEG C, homogenizing 1 time emulsion, finally in inlet temperature be 190 DEG C, outlet temperature is 90 DEG C, atomizing pressure be the condition of 0.4MPa under spraying dry, obtained Chinese herbal medicine essential oil microcapsules.
Claims (8)
1. a preparation method for Chinese herbal medicine microcapsule, is characterized in that, comprises the steps:
A. be that maltodextrin and the soybean protein isolate of 3:1 ~ 2 is dissolved in the water of 70 ~ 80 DEG C by wall material weight ratio, obtain solution A;
B. Chinese herbal medicine quintessence oil and emulsifying agent sucrose ester are dissolved in the water of 50 ~ 60 DEG C, obtain solution B;
C. solution A and solution B are mixed while hot, stir, obtain emulsion through high pressure homogenize, finally by spray drying technology, obtained Chinese herbal medicine essential oil microcapsules.
2. the preparation method of a kind of Chinese herbal medicine essential oil microcapsules according to claim 1, it is characterized in that, the percentage ratio that each amounts of components of Chinese herbal medicine quintessence oil described in step b accounts for all components weight is: Chinese herbal medicine quintessence oil 15 ~ 30%, emulsifying agent 1 ~ 2%, wall material 68 ~ 84%.
3. the preparation method of a kind of Chinese herbal medicine essential oil microcapsules according to claim 1, is characterized in that, the Chinese herbal medicine quintessence oil described in step b is the P-Cymene of weight ratio 1 ~ 3:1 ~ 3:2:2, Herba Achilleae quintessence oil, Herba Schizonepetae quintessence oil and Rhizoma Atractylodis quintessence oil.
4. the preparation method of a kind of Chinese herbal medicine essential oil microcapsules according to claim 1, is characterized in that, the homogenization pressure described in step c is 20 ~ 30MPa, and temperature is 60 ~ 70 DEG C, and cycle-index is 1 ~ 3 time.
5. the preparation method of a kind of Chinese herbal medicine essential oil microcapsules according to claim 1, is characterized in that, the spray drying condition described in step c is inlet temperature is 180 ~ 200 DEG C, and outlet temperature is 80 ~ 100 DEG C, and atomizing pressure is 0.2 ~ 0.5MPa.
6. the Chinese herbal medicine essential oil microcapsules that 1 ~ 5 arbitrary described preparation method is obtained as requested.
7. the gel of washing one's hands containing, for example Chinese herbal medicine essential oil microcapsules according to claim 6.
8. gel of washing one's hands according to claim 7, is characterized in that, the weight percent content of described Chinese herbal medicine essential oil microcapsules is 1 ~ 10%.
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Cited By (9)
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| CN105213271A (en) * | 2015-11-03 | 2016-01-06 | 重庆小丸科贸有限公司 | A kind of preparation method containing the sunscreen cream of repair function microcapsule after solarization |
| CN105250200A (en) * | 2015-10-30 | 2016-01-20 | 重庆小丸科贸有限公司 | Preparation method of microcapsule type eye shadow |
| CN105248460A (en) * | 2015-10-09 | 2016-01-20 | 广州潮徽化工科技有限公司 | Compound antimicrobial composition containing microcapsules and preparation method and application of compound antimicrobial composition |
| CN105771827A (en) * | 2015-12-10 | 2016-07-20 | 上海应用技术学院 | Method for preparing water-soluble plant essential oil nanoparticles |
| CN106563005A (en) * | 2016-12-15 | 2017-04-19 | 安徽普元生物科技股份有限公司 | Chewing gum capable of promoting aphtha healing and preparation method of chewing gum |
| CN107823602A (en) * | 2017-11-28 | 2018-03-23 | 戴凤 | A kind of Chinese herbal medicine essential oil antibacterial microcapsule and preparation method thereof |
| CN107927687A (en) * | 2017-11-10 | 2018-04-20 | 天津春发生物科技集团有限公司 | A kind of method that Vacuum Freezing ＆ Drying Technology prepares essence microcapsule |
| CN112546082A (en) * | 2020-11-13 | 2021-03-26 | 武汉国灸科技开发有限公司 | Traditional Chinese medicine preparation for quickly inhibiting nasopharyngeal bacteria and preparation method thereof |
| CN115845237A (en) * | 2022-11-26 | 2023-03-28 | 绍兴帛颂针纺有限公司 | Cloth with physical therapy function and production process and application thereof |
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- 2015-05-26 CN CN201510270173.XA patent/CN104906185A/en active Pending
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| CN105248460A (en) * | 2015-10-09 | 2016-01-20 | 广州潮徽化工科技有限公司 | Compound antimicrobial composition containing microcapsules and preparation method and application of compound antimicrobial composition |
| CN105248460B (en) * | 2015-10-09 | 2018-02-06 | 广州潮徽生物科技有限公司 | A kind of composite antibacterial composition containing microcapsules and preparation method and application |
| CN105250200A (en) * | 2015-10-30 | 2016-01-20 | 重庆小丸科贸有限公司 | Preparation method of microcapsule type eye shadow |
| CN105250200B (en) * | 2015-10-30 | 2018-06-08 | 重庆小丸科贸有限公司 | A kind of preparation method of microcapsule-type eye shadow cream |
| CN105213271A (en) * | 2015-11-03 | 2016-01-06 | 重庆小丸科贸有限公司 | A kind of preparation method containing the sunscreen cream of repair function microcapsule after solarization |
| CN105213271B (en) * | 2015-11-03 | 2018-06-19 | 重庆小丸科贸有限公司 | A kind of preparation method of the suncream containing after-sun function microcapsules |
| CN105771827A (en) * | 2015-12-10 | 2016-07-20 | 上海应用技术学院 | Method for preparing water-soluble plant essential oil nanoparticles |
| CN106563005A (en) * | 2016-12-15 | 2017-04-19 | 安徽普元生物科技股份有限公司 | Chewing gum capable of promoting aphtha healing and preparation method of chewing gum |
| CN107927687A (en) * | 2017-11-10 | 2018-04-20 | 天津春发生物科技集团有限公司 | A kind of method that Vacuum Freezing ＆ Drying Technology prepares essence microcapsule |
| CN107823602A (en) * | 2017-11-28 | 2018-03-23 | 戴凤 | A kind of Chinese herbal medicine essential oil antibacterial microcapsule and preparation method thereof |
| CN112546082A (en) * | 2020-11-13 | 2021-03-26 | 武汉国灸科技开发有限公司 | Traditional Chinese medicine preparation for quickly inhibiting nasopharyngeal bacteria and preparation method thereof |
| CN115845237A (en) * | 2022-11-26 | 2023-03-28 | 绍兴帛颂针纺有限公司 | Cloth with physical therapy function and production process and application thereof |
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Application publication date: 20150916 |
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