CN107823602A - A kind of Chinese herbal medicine essential oil antibacterial microcapsule and preparation method thereof - Google Patents
A kind of Chinese herbal medicine essential oil antibacterial microcapsule and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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Abstract
The invention discloses a kind of Chinese herbal medicine essential oil antibacterial microcapsule and preparation method thereof, by horseradish essential oil, P-Cymene, Zingiber corallinum Hance essential oil, cinnamon essential oil mixing is used as capsule-core, with chitosan, casein sodium, konjac glucomannan, carboxymethyl cellulose cyst material the most, using sucrose ester as emulsifying agent, Chinese herbal medicine essential oil with antibacterial bacteriostatic drug effect is carried out by embedding treatment using microcapsules technology, pass through the Chinese herbal medicine essential oil of reasonably combined different antibacterial bacteriostatic effects, the microcapsules not only have broad-spectrum antiseptic bacteriostasis efficacy, anti-bacterial, anti-itching positive effect, also there is good stability and long-term effect, the antibacterial and bacteriostasis time is grown, toxic side effect is small.
Description
Technical field
The invention belongs to medicine, daily chemical product technical field, and in particular to a kind of Chinese herbal medicine essential oil antibacterial microcapsule and its
Preparation method.
Background technology
Essential oil is that a kind of material with volatility and aromatic odor extracted is refined from natural plants.And Chinese medicine
Essential oil is then a kind of special essential oil with medicine interaction property, at present in fields such as medicine, daily use chemicals production, food industry
All it is widely used.
Prove that essential oil of traditional Chinese medicine has a variety of pharmacological activity, such as through long-term pharmacology and clinical medicine：Anti-oxidant, anti-inflammatory, suppression
Bacterium, sterilization, antiviral or desinsection etc. act on.But easily it is vaporized under its normal temperature, and it is oxidizable rotten, it have impact on its application effect.
Horseradish is a kind of special edible health plant found in the world today, has abundant nutritional ingredient, also has
There are immunoregulation effect and the multiple pharmacological effect such as antibacterial, anticancer, anti-oxidant.There are some researches show the plant tissue of horseradish is broken
After bad, the glucosinolate in its tissue occurs enzymolysis and discharges volatile isothiocyanates (ITCs) and produce unique pungent
Peppery flavor, ITCs have the function that parasite in sterilization, mould proof and elimination alimentary canal.
Folium artemisiae argyi is one of traditional Chinese medical science common medicine, and modern experimental research has shown that, folium artemisiae argyi has antibacterial, antiviral, antiallergy and rush
Enter a variety of pharmacological effects such as blood circulation, to streptococcus pneumonia, staphylococcus aureus, Escherichia coli, gram-Negative bacillus
And a variety of fungies have inhibitory action.
Have at present using horseradish or folium artemisiae argyi as the document report of antibacterial detergent, cleaning material etc., but used micro-
Capsule technique its essential oil is carried out embedding prepare microcapsules research it is also less.
Microcapsules technology be it is a kind of using filmogen by some have reactivity, sensitiveness or volatile liquid or
Solid encapsulates a kind of protection technique to form fine particle, and the process of encapsulating is microencapsulation, and the fine particle of formation is referred to as
Microcapsules.The function of microcapsules mainly has：When prevent or slow down the protections such as unstable core material volatilization, oxidation and corruption
The effect of core；Second, the shortcomings that overcoming some core material poor fluidities, not easy to maintain, inconvenient transport；Third, cover core
The bad smell or taste of material material, core material is set slowly to discharge according to certain requirement.
Essential oil is wrapped up using microcapsules technology, the chemical stability of essential oil of traditional Chinese medicine can be effectively kept, avoid
Loss in storage process.Further, since Microcapsules Size is small, surface area is big, can reach the effect of controlled release, extends Chinese medicine essence
The efficacy time of oil.
The content of the invention
For overcome the deficiencies in the prior art, the invention provides a kind of Chinese herbal medicine essential oil antibacterial microcapsule and its preparation side
Method, the Chinese herbal medicine essential oil with antibacterial bacteriostatic drug effect is carried out by embedding treatment using microcapsules technology, passes through reasonably combined difference
The Chinese herbal medicine essential oil of antibacterial bacteriostatic effect, the microcapsules not only have broad-spectrum antiseptic bacteriostasis efficacy, anti-bacterial, anti-itching positive effect, gone back
It is small with good stability and long-term effect, antibacterial and bacteriostasis time length, toxic side effect.
A kind of Chinese herbal medicine essential oil antibacterial microcapsule provided by the invention, including capsule-core and cyst wall, the capsule-core is by horseradish essence
Oil, P-Cymene, Zingiber corallinum Hance essential oil, cinnamon essential oil combine, and the cyst wall is by chitosan, casein sodium, konjac glucomannan, carboxylic
Methylcellulose mixes.
The mass ratio of capsule-core and cyst wall is 1~2 in the present invention：1~3.5.
Horseradish essential oil, P-Cymene, Zingiber corallinum Hance essential oil, the mass ratio of cinnamon essential oil are 1~5 in capsule-core of the present invention：1~3：
1：1~2.
Chitosan, casein sodium, konjac glucomannan, the mass ratio of carboxymethyl cellulose are 1 in cyst wall of the present invention：1~3：0.5
~1.5：1~2.
A kind of Chinese herbal medicine essential oil antibacterial microcapsule provided by the invention, its preparation process include following steps：
(1) horseradish essential oil, P-Cymene, Zingiber corallinum Hance essential oil, cinnamon essential oil are mixed in proportion, adds emulsifying agent and enter
Row emulsifying forms capsule-core solution；
(2) chitosan, casein sodium, konjac glucomannan, carboxymethyl cellulose are mixed in proportion, adds deionized water
It is ultrasonically treated, forms capsule wall solution；
(3) capsule-core solution is mixed with capsule wall solution, mixed with ultrahigh speed mixing machine, then enter horizontal high voltage with homogenizer
Homogeneous, obtain emulsion；
(4) emulsion is dried to obtain microcapsules using spray drying or vacuum freeze drying.
From sucrose ester as emulsifying agent in the present invention, HLB value is 8~10.
Embodiment
With specific embodiment, the invention will be further described below, but the invention is not limited in these embodiments.
Embodiment 1
By horseradish essential oil, P-Cymene, Zingiber corallinum Hance essential oil, cinnamon essential oil in mass ratio 1：3：1：1 is mixed, and is added
The sucrose ester that HLB value is 8 carries out emulsifying and forms capsule-core solution；Chitosan, casein sodium, konjac glucomannan, carboxymethyl is fine
Dimension element in mass ratio 1：1：1.5：2 are mixed, and are added deionized water and are ultrasonically treated, form capsule wall solution；Capsule-core is molten
Liquid and capsule wall solution in mass ratio 1：1 is mixed, and is mixed with ultrahigh speed mixing machine, then with homogenizer to enter horizontal high voltage equal
Matter, obtain emulsion；Emulsion is dried to obtain Chinese herbal medicine essential oil antibacterial microcapsule using spray drying.
Embodiment 2
By horseradish essential oil, P-Cymene, Zingiber corallinum Hance essential oil, cinnamon essential oil in mass ratio 5：1：1：2 are mixed, and are added
The sucrose ester that HLB value is 10 carries out emulsifying and forms capsule-core solution；Chitosan, casein sodium, konjac glucomannan, carboxymethyl is fine
Dimension element in mass ratio 1：3：1：1 is mixed, and is added deionized water and is ultrasonically treated, forms capsule wall solution；By capsule-core solution
With capsule wall solution in mass ratio 2：3.5 are mixed, and are mixed with ultrahigh speed mixing machine, then with homogenizer to enter horizontal high voltage equal
Matter, obtain emulsion；Emulsion is dried using vacuum freeze drying to obtain Chinese herbal medicine essential oil antibacterial microcapsule.
Embodiment 3
By horseradish essential oil, P-Cymene, Zingiber corallinum Hance essential oil, cinnamon essential oil in mass ratio 3：2：1：1.5 are mixed, and are added
The sucrose ester that HLB value is 9 carries out emulsifying and forms capsule-core solution；Chitosan, casein sodium, konjac glucomannan, carboxymethyl is fine
Dimension element in mass ratio 1：2：0.5：1.5 are mixed, and are added deionized water and are ultrasonically treated, form capsule wall solution；By capsule-core
Solution and capsule wall solution in mass ratio 1：2 are mixed, and are mixed with ultrahigh speed mixing machine, then with homogenizer to enter horizontal high voltage equal
Matter, obtain emulsion；Emulsion is dried to obtain Chinese herbal medicine essential oil antibacterial microcapsule using spray drying.
Embodiment 4
By horseradish essential oil, P-Cymene, Zingiber corallinum Hance essential oil, cinnamon essential oil in mass ratio 4：2：1：1.5 are mixed, and are added
The sucrose ester that HLB value is 8 carries out emulsifying and forms capsule-core solution；Chitosan, casein sodium, konjac glucomannan, carboxymethyl is fine
Dimension element in mass ratio 1：1.5：0.5：1.5 are mixed, and are added deionized water and are ultrasonically treated, form capsule wall solution；By capsule
Core solution and capsule wall solution in mass ratio 1：3 are mixed, and are mixed with ultrahigh speed mixing machine, then enter horizontal high voltage with homogenizer
Homogeneous, obtain emulsion；Emulsion is dried to obtain Chinese herbal medicine essential oil antibacterial microcapsule using spray drying.
Embodiment 5
By horseradish essential oil, P-Cymene, Zingiber corallinum Hance essential oil, cinnamon essential oil in mass ratio 3.5：2：1：1.5 are mixed, and are added
Enter the sucrose ester that HLB value is 10 and carry out emulsifying formation capsule-core solution；By chitosan, casein sodium, konjac glucomannan, carboxymethyl
Cellulose in mass ratio 1：2.5：1：1 is mixed, and is added deionized water and is ultrasonically treated, forms capsule wall solution；By capsule-core
Solution and capsule wall solution in mass ratio 2：3 are mixed, and are mixed with ultrahigh speed mixing machine, then with homogenizer to enter horizontal high voltage equal
Matter, obtain emulsion；Emulsion is dried to obtain Chinese herbal medicine essential oil antibacterial microcapsule using spray drying.
Claims (6)
- A kind of 1. Chinese herbal medicine essential oil antibacterial microcapsule, it is characterised in that including capsule-core and cyst wall, the capsule-core by horseradish essential oil, P-Cymene, Zingiber corallinum Hance essential oil, cinnamon essential oil combine, and the cyst wall is by chitosan, casein sodium, konjac glucomannan, carboxylic first Base cellulose mixes.
- 2. Chinese herbal medicine essential oil antibacterial microcapsule according to claim 1, it is characterised in that the quality of the capsule-core and cyst wall Than for 1~2：1~3.5.
- 3. Chinese herbal medicine essential oil antibacterial microcapsule according to claim 1, it is characterised in that horseradish essential oil in the capsule-core, P-Cymene, Zingiber corallinum Hance essential oil, the mass ratio of cinnamon essential oil are 1~5：1~3：1：1~2.
- 4. Chinese herbal medicine essential oil antibacterial microcapsule according to claim 1, it is characterised in that chitosan, junket in the cyst wall Protein acid sodium, konjac glucomannan, the mass ratio of carboxymethyl cellulose are 1：1~3：0.5~1.5：1~2.
- 5. Chinese herbal medicine essential oil antibacterial microcapsule according to claim 1, it is characterised in that its preparation process includes following step Suddenly：(1) horseradish essential oil, P-Cymene, Zingiber corallinum Hance essential oil, cinnamon essential oil are mixed in proportion, adds emulsifying agent and carry out Matter emulsifies to form capsule-core solution；(2) chitosan, casein sodium, konjac glucomannan, carboxymethyl cellulose are mixed in proportion, adds deionized water and carry out It is ultrasonically treated, forms capsule wall solution；(3) capsule-core solution is mixed with capsule wall solution, mixed with ultrahigh speed mixing machine, then with homogenizer to enter horizontal high voltage equal Matter, obtain emulsion；(4) emulsion is dried to obtain microcapsules using spray drying or vacuum freeze drying.
- 6. step according to claim 5, it is characterised in that the emulsifying agent is sucrose ester, and HLB value is 8~10.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109125189A (en) * | 2018-10-31 | 2019-01-04 | 广东巴松那生物科技有限公司 | A kind of inclusion enclave Essence and preparation method thereof of the instant bright color of energy |
| CN109999736A (en) * | 2019-04-24 | 2019-07-12 | 东莞市枭森环保科技有限公司 | A kind of microcapsules and preparation method thereof containing plant characteristics fragrance |
| CN110117906A (en) * | 2019-05-08 | 2019-08-13 | 安徽省翰先纺织科技有限公司 | Printed fabric production technology |
| CN111296433A (en) * | 2020-03-27 | 2020-06-19 | 南京芬之怡生物科技有限公司 | Green disinfection and sterilization material and preparation method thereof |
| CN111909755A (en) * | 2020-08-11 | 2020-11-10 | 国网河南省电力公司社旗县供电公司 | Preparation method of plant insulating oil for power transformer |
| CN112618419A (en) * | 2021-01-12 | 2021-04-09 | 合肥香觉健康咨询有限公司 | Aromatic essential oil face cream |
| CN114989889A (en) * | 2022-05-18 | 2022-09-02 | 广东本研新材料科技有限公司 | Preparation method of plant essential oil microspheres |
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| CN103784345A (en) * | 2012-10-29 | 2014-05-14 | 烟台大洋制药有限公司 | Healthy bactericidal anti-itching cosmetic |
| CN103876242A (en) * | 2014-04-01 | 2014-06-25 | 广东工业大学 | Microcapsule capable of resisting food-borne pathogenic bacteria as well as preparation method and application thereof |
| CN104341871A (en) * | 2013-08-06 | 2015-02-11 | 青岛益群漆业集团有限公司 | Antibacterial environment-friendly paint |
| CN104906185A (en) * | 2015-05-26 | 2015-09-16 | 南京泽朗医药科技有限公司 | Chinese herbal medicine essential oil microcapsule and preparation method and application thereof |
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2017
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| CN103784345A (en) * | 2012-10-29 | 2014-05-14 | 烟台大洋制药有限公司 | Healthy bactericidal anti-itching cosmetic |
| CN104341871A (en) * | 2013-08-06 | 2015-02-11 | 青岛益群漆业集团有限公司 | Antibacterial environment-friendly paint |
| CN103876242A (en) * | 2014-04-01 | 2014-06-25 | 广东工业大学 | Microcapsule capable of resisting food-borne pathogenic bacteria as well as preparation method and application thereof |
| CN104906185A (en) * | 2015-05-26 | 2015-09-16 | 南京泽朗医药科技有限公司 | Chinese herbal medicine essential oil microcapsule and preparation method and application thereof |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109125189A (en) * | 2018-10-31 | 2019-01-04 | 广东巴松那生物科技有限公司 | A kind of inclusion enclave Essence and preparation method thereof of the instant bright color of energy |
| CN109999736A (en) * | 2019-04-24 | 2019-07-12 | 东莞市枭森环保科技有限公司 | A kind of microcapsules and preparation method thereof containing plant characteristics fragrance |
| CN110117906A (en) * | 2019-05-08 | 2019-08-13 | 安徽省翰先纺织科技有限公司 | Printed fabric production technology |
| CN111296433A (en) * | 2020-03-27 | 2020-06-19 | 南京芬之怡生物科技有限公司 | Green disinfection and sterilization material and preparation method thereof |
| CN111909755A (en) * | 2020-08-11 | 2020-11-10 | 国网河南省电力公司社旗县供电公司 | Preparation method of plant insulating oil for power transformer |
| CN112618419A (en) * | 2021-01-12 | 2021-04-09 | 合肥香觉健康咨询有限公司 | Aromatic essential oil face cream |
| CN112618419B (en) * | 2021-01-12 | 2023-04-11 | 同芙集团(中国)股份有限公司 | Aromatic essential oil face cream |
| CN114989889A (en) * | 2022-05-18 | 2022-09-02 | 广东本研新材料科技有限公司 | Preparation method of plant essential oil microspheres |
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