CN106053835A - 川崎病的诊断标志物和治疗靶点 - Google Patents

川崎病的诊断标志物和治疗靶点 Download PDF

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Publication number
CN106053835A
CN106053835A CN201610498798.6A CN201610498798A CN106053835A CN 106053835 A CN106053835 A CN 106053835A CN 201610498798 A CN201610498798 A CN 201610498798A CN 106053835 A CN106053835 A CN 106053835A
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CN
China
Prior art keywords
biomarker
filamin
level
kit
patients
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Pending
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CN201610498798.6A
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English (en)
Chinese (zh)
Inventor
亚历克斯·肯特赛斯
苏姗·金
汉诺·斯泰恩
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Boston Childrens Hospital
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Boston Childrens Hospital
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Application filed by Boston Childrens Hospital filed Critical Boston Childrens Hospital
Publication of CN106053835A publication Critical patent/CN106053835A/zh
Pending legal-status Critical Current

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486Metalloendopeptidases (3.4.24)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/32Cardiovascular disorders
    • G01N2800/328Vasculitis, i.e. inflammation of blood vessels
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/60Complex ways of combining multiple protein biomarkers for diagnosis

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201610498798.6A 2011-04-15 2012-04-13 川崎病的诊断标志物和治疗靶点 Pending CN106053835A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161475936P 2011-04-15 2011-04-15
US61/475,936 2011-04-15
US201161579007P 2011-12-22 2011-12-22
US61/579,007 2011-12-22
CN201280024575.6A CN103562725B (zh) 2011-04-15 2012-04-13 川崎病的诊断标志物和治疗靶点

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201280024575.6A Division CN103562725B (zh) 2011-04-15 2012-04-13 川崎病的诊断标志物和治疗靶点

Publications (1)

Publication Number Publication Date
CN106053835A true CN106053835A (zh) 2016-10-26

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN201610498798.6A Pending CN106053835A (zh) 2011-04-15 2012-04-13 川崎病的诊断标志物和治疗靶点
CN201280024575.6A Expired - Fee Related CN103562725B (zh) 2011-04-15 2012-04-13 川崎病的诊断标志物和治疗靶点

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Country Link
US (1) US9869673B2 (enExample)
EP (2) EP2697653B1 (enExample)
JP (1) JP6072768B2 (enExample)
KR (1) KR20140034193A (enExample)
CN (2) CN106053835A (enExample)
AU (1) AU2012242684B2 (enExample)
CA (1) CA2833257A1 (enExample)
WO (1) WO2012142409A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI704349B (zh) * 2019-06-17 2020-09-11 高雄榮民總醫院 蛋白質生物標記用以診斷川崎症的用途

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Publication number Priority date Publication date Assignee Title
EP3137907A4 (en) * 2014-05-02 2018-02-28 Momenta Pharmaceuticals, Inc. Methods and compositions for the diagnosis and treatment of kawasaki disease
CN106796221B (zh) * 2014-07-24 2019-12-17 陈垣崇 川崎氏症的诊断与治疗
KR102056405B1 (ko) 2018-04-05 2019-12-16 (주)메디젠휴먼케어 Ebf2 유전자 다형성을 이용한 가와사키병 발병 예측 방법
CN110763845B (zh) * 2018-07-27 2022-10-28 成都市第三人民医院 一种检测蛋白标志物的配体在制备用于诊断结肠癌的产品中的用途和试剂盒
JPWO2022071601A1 (enExample) * 2020-10-02 2022-04-07
CN116087519B (zh) * 2021-05-17 2025-03-14 郑州大学第一附属医院 一种用于高危人群贲门腺癌早期筛查的标志物及其应用
KR102705469B1 (ko) * 2022-05-30 2024-09-11 충남대학교산학협력단 불응성 가와사키병의 감별 진단을 위한 정보 제공 방법

Citations (1)

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US20090093005A1 (en) * 2007-10-05 2009-04-09 University Of Virginia Patent Foundation Protein-based biomarkers for abdominal aortic aneurysm

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US7429466B2 (en) 2000-01-24 2008-09-30 Hypromatrix, Inc Methods and arrays for detecting biological molecules
US7112408B2 (en) 2001-06-08 2006-09-26 The Brigham And Women's Hospital, Inc. Detection of ovarian cancer based upon alpha-haptoglobin levels
US6905827B2 (en) * 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
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WO2007003594A1 (en) * 2005-07-01 2007-01-11 Solvay Pharmaceuticals Gmbh Screening methods for inhibitors of the metalloprotease meprin
JP4795037B2 (ja) 2006-02-01 2011-10-19 財団法人 神戸市地域医療振興財団 川崎病の判定方法及びそのためのキット
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US20090093005A1 (en) * 2007-10-05 2009-04-09 University Of Virginia Patent Foundation Protein-based biomarkers for abdominal aortic aneurysm

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MING-YII HUANG,ET AL.: "Acute-Phase Reactants and a Supplemental Diagnostic Aid for Kawasaki Disease", 《PEDIATR CARDIOL.》 *
RYOTA EBATA,ET AL.: "Increased Production of Vascular Endothelial Growth Factor-D and Lymphangiogenesis in Acute Kawasaki Disease", 《CIRCULATION JOURNAL》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI704349B (zh) * 2019-06-17 2020-09-11 高雄榮民總醫院 蛋白質生物標記用以診斷川崎症的用途

Also Published As

Publication number Publication date
EP2697653A2 (en) 2014-02-19
AU2012242684A1 (en) 2013-10-31
KR20140034193A (ko) 2014-03-19
WO2012142409A3 (en) 2013-02-28
JP2014512014A (ja) 2014-05-19
US9869673B2 (en) 2018-01-16
CA2833257A1 (en) 2012-10-18
CN103562725A (zh) 2014-02-05
EP3086121A1 (en) 2016-10-26
US20140161791A1 (en) 2014-06-12
CN103562725B (zh) 2016-08-17
WO2012142409A2 (en) 2012-10-18
AU2012242684B2 (en) 2017-04-20
JP6072768B2 (ja) 2017-02-01
EP2697653B1 (en) 2016-03-30

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