CA2833257A1 - Diagnostic markers and therapeutic targets of kawasaki disease - Google Patents
Diagnostic markers and therapeutic targets of kawasaki disease Download PDFInfo
- Publication number
- CA2833257A1 CA2833257A1 CA2833257A CA2833257A CA2833257A1 CA 2833257 A1 CA2833257 A1 CA 2833257A1 CA 2833257 A CA2833257 A CA 2833257A CA 2833257 A CA2833257 A CA 2833257A CA 2833257 A1 CA2833257 A1 CA 2833257A1
- Authority
- CA
- Canada
- Prior art keywords
- biomarker
- level
- filamin
- acc
- meprin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 208000011200 Kawasaki disease Diseases 0.000 title claims abstract description 229
- 208000001725 mucocutaneous lymph node syndrome Diseases 0.000 title claims abstract description 229
- 230000001225 therapeutic effect Effects 0.000 title abstract description 12
- 239000000090 biomarker Substances 0.000 claims abstract description 151
- 102000013366 Filamin Human genes 0.000 claims abstract description 109
- 108060002900 Filamin Proteins 0.000 claims abstract description 109
- 108090000265 Meprin A Proteins 0.000 claims abstract description 92
- 238000000034 method Methods 0.000 claims abstract description 39
- 238000001514 detection method Methods 0.000 claims abstract description 10
- 108090000623 proteins and genes Proteins 0.000 claims description 103
- 102000004169 proteins and genes Human genes 0.000 claims description 102
- 210000002700 urine Anatomy 0.000 claims description 65
- 239000012472 biological sample Substances 0.000 claims description 53
- 239000000523 sample Substances 0.000 claims description 46
- 210000002966 serum Anatomy 0.000 claims description 45
- 238000011282 treatment Methods 0.000 claims description 38
- 239000003795 chemical substances by application Substances 0.000 claims description 34
- 238000003556 assay Methods 0.000 claims description 23
- 238000010606 normalization Methods 0.000 claims description 8
- 239000011230 binding agent Substances 0.000 claims description 6
- 230000008859 change Effects 0.000 claims description 6
- 239000003153 chemical reaction reagent Substances 0.000 claims description 6
- 108010074605 gamma-Globulins Proteins 0.000 claims description 5
- 238000004802 monitoring treatment efficacy Methods 0.000 claims description 2
- 238000008157 ELISA kit Methods 0.000 claims 1
- 108091008147 housekeeping proteins Proteins 0.000 claims 1
- 108010026552 Proteome Proteins 0.000 abstract description 18
- 238000002560 therapeutic procedure Methods 0.000 abstract description 10
- 239000000203 mixture Substances 0.000 abstract description 4
- 235000018102 proteins Nutrition 0.000 description 94
- 238000003745 diagnosis Methods 0.000 description 24
- 230000027455 binding Effects 0.000 description 14
- 238000002965 ELISA Methods 0.000 description 13
- 238000004458 analytical method Methods 0.000 description 13
- 210000004351 coronary vessel Anatomy 0.000 description 11
- 108090000765 processed proteins & peptides Proteins 0.000 description 10
- 230000002485 urinary effect Effects 0.000 description 10
- 241000699670 Mus sp. Species 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 9
- 201000010099 disease Diseases 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 108010074051 C-Reactive Protein Proteins 0.000 description 8
- 102100032752 C-reactive protein Human genes 0.000 description 8
- 108090000695 Cytokines Proteins 0.000 description 8
- 102000004127 Cytokines Human genes 0.000 description 8
- 238000011156 evaluation Methods 0.000 description 8
- 238000005259 measurement Methods 0.000 description 8
- 238000010172 mouse model Methods 0.000 description 8
- 230000004044 response Effects 0.000 description 8
- 102100031262 Deleted in malignant brain tumors 1 protein Human genes 0.000 description 7
- 101000844721 Homo sapiens Deleted in malignant brain tumors 1 protein Proteins 0.000 description 7
- 102000004196 processed proteins & peptides Human genes 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 239000003550 marker Substances 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- 206010003232 Arteritis coronary Diseases 0.000 description 5
- 206010037660 Pyrexia Diseases 0.000 description 5
- 239000012895 dilution Substances 0.000 description 5
- 238000010790 dilution Methods 0.000 description 5
- 238000001990 intravenous administration Methods 0.000 description 5
- 238000003127 radioimmunoassay Methods 0.000 description 5
- 230000035945 sensitivity Effects 0.000 description 5
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 4
- 102100040807 CUB and sushi domain-containing protein 3 Human genes 0.000 description 4
- 108700039887 Essential Genes Proteins 0.000 description 4
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 4
- 101000892045 Homo sapiens CUB and sushi domain-containing protein 3 Proteins 0.000 description 4
- 208000036142 Viral infection Diseases 0.000 description 4
- 229960001138 acetylsalicylic acid Drugs 0.000 description 4
- 238000013459 approach Methods 0.000 description 4
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 239000012634 fragment Substances 0.000 description 4
- 238000003018 immunoassay Methods 0.000 description 4
- 230000001976 improved effect Effects 0.000 description 4
- 230000003902 lesion Effects 0.000 description 4
- 230000007310 pathophysiology Effects 0.000 description 4
- 239000002953 phosphate buffered saline Substances 0.000 description 4
- 238000010200 validation analysis Methods 0.000 description 4
- 102100028281 ABC-type oligopeptide transporter ABCB9 Human genes 0.000 description 3
- 206010010741 Conjunctivitis Diseases 0.000 description 3
- 208000010201 Exanthema Diseases 0.000 description 3
- 108060003951 Immunoglobulin Proteins 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 101000844719 Mus musculus Deleted in malignant brain tumors 1 protein Proteins 0.000 description 3
- 108010083809 Talin Proteins 0.000 description 3
- 102000006463 Talin Human genes 0.000 description 3
- 206010047115 Vasculitis Diseases 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 239000011324 bead Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 239000013068 control sample Substances 0.000 description 3
- 210000003743 erythrocyte Anatomy 0.000 description 3
- 201000005884 exanthem Diseases 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 238000000589 high-performance liquid chromatography-mass spectrometry Methods 0.000 description 3
- 229940124644 immune regulator Drugs 0.000 description 3
- 102000018358 immunoglobulin Human genes 0.000 description 3
- 210000000265 leukocyte Anatomy 0.000 description 3
- 238000004949 mass spectrometry Methods 0.000 description 3
- 230000003278 mimic effect Effects 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 206010037844 rash Diseases 0.000 description 3
- 238000004062 sedimentation Methods 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 230000003595 spectral effect Effects 0.000 description 3
- 238000004885 tandem mass spectrometry Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 108010085238 Actins Proteins 0.000 description 2
- 102000007469 Actins Human genes 0.000 description 2
- 102100026446 Aldo-keto reductase family 1 member C1 Human genes 0.000 description 2
- 108091023037 Aptamer Proteins 0.000 description 2
- 108010078791 Carrier Proteins Proteins 0.000 description 2
- 108010002947 Connectin Proteins 0.000 description 2
- 206010011071 Coronary artery aneurysm Diseases 0.000 description 2
- 206010065420 Coronary artery dilatation Diseases 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 102100029115 Fumarylacetoacetase Human genes 0.000 description 2
- 102100030875 Gastricsin Human genes 0.000 description 2
- 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 2
- 102100040896 Growth/differentiation factor 15 Human genes 0.000 description 2
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 description 2
- 101000724357 Homo sapiens ABC-type oligopeptide transporter ABCB9 Proteins 0.000 description 2
- 101000893549 Homo sapiens Growth/differentiation factor 15 Proteins 0.000 description 2
- 101001050318 Homo sapiens Junctional adhesion molecule-like Proteins 0.000 description 2
- 101001138062 Homo sapiens Leukocyte-associated immunoglobulin-like receptor 1 Proteins 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 102100023437 Junctional adhesion molecule-like Human genes 0.000 description 2
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 2
- 244000199866 Lactobacillus casei Species 0.000 description 2
- 102100020943 Leukocyte-associated immunoglobulin-like receptor 1 Human genes 0.000 description 2
- 208000008771 Lymphadenopathy Diseases 0.000 description 2
- 102100030417 Matrilysin Human genes 0.000 description 2
- 102100030876 Meprin A subunit beta Human genes 0.000 description 2
- 208000009525 Myocarditis Diseases 0.000 description 2
- 102100030127 Obscurin Human genes 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- 206010037596 Pyelonephritis Diseases 0.000 description 2
- 208000008718 Pyuria Diseases 0.000 description 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 2
- 208000004732 Systemic Vasculitis Diseases 0.000 description 2
- 102100026260 Titin Human genes 0.000 description 2
- 102000004243 Tubulin Human genes 0.000 description 2
- 108090000704 Tubulin Proteins 0.000 description 2
- 208000012931 Urologic disease Diseases 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 238000002820 assay format Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000005779 cell damage Effects 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 229960003067 cystine Drugs 0.000 description 2
- 230000009266 disease activity Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000003511 endothelial effect Effects 0.000 description 2
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 2
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 2
- 208000019622 heart disease Diseases 0.000 description 2
- 238000002991 immunohistochemical analysis Methods 0.000 description 2
- 238000003364 immunohistochemistry Methods 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 208000017169 kidney disease Diseases 0.000 description 2
- 238000012417 linear regression Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000001000 micrograph Methods 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 108010089193 pattern recognition receptors Proteins 0.000 description 2
- 102000007863 pattern recognition receptors Human genes 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 235000019419 proteases Nutrition 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 230000000306 recurrent effect Effects 0.000 description 2
- 239000013074 reference sample Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 150000003384 small molecules Chemical class 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 230000032258 transport Effects 0.000 description 2
- 208000014001 urinary system disease Diseases 0.000 description 2
- FLEHQRTTWKDNGI-XTJILODYSA-N (1s,3r)-5-[(2e)-2-[(7ar)-1-[(2s)-5-(cyclopropylamino)pentan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-2-methylidenecyclohexane-1,3-diol Chemical compound C([C@H](C)C1[C@]2(CCCC(/C2CC1)=C\C=C1C[C@@H](O)C(=C)[C@@H](O)C1)C)CCNC1CC1 FLEHQRTTWKDNGI-XTJILODYSA-N 0.000 description 1
- 102100021408 14-3-3 protein beta/alpha Human genes 0.000 description 1
- 238000011265 2D-echocardiography Methods 0.000 description 1
- 102100027271 40S ribosomal protein SA Human genes 0.000 description 1
- 102100022530 45 kDa calcium-binding protein Human genes 0.000 description 1
- 102100037685 60S ribosomal protein L22 Human genes 0.000 description 1
- 102100035841 60S ribosomal protein L7 Human genes 0.000 description 1
- 101710192090 ABC-type oligopeptide transporter ABCB9 Proteins 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 102100037768 Acetyl-CoA acetyltransferase, mitochondrial Human genes 0.000 description 1
- 102100029631 Actin-related protein 3B Human genes 0.000 description 1
- 102000011767 Acute-Phase Proteins Human genes 0.000 description 1
- 108010062271 Acute-Phase Proteins Proteins 0.000 description 1
- 102100031786 Adiponectin Human genes 0.000 description 1
- 102100028444 Aflatoxin B1 aldehyde reductase member 3 Human genes 0.000 description 1
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 description 1
- 108010082126 Alanine transaminase Proteins 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 101710117294 Aldo-keto reductase family 1 member C1 Proteins 0.000 description 1
- 102100031890 Aminopeptidase NAALADL1 Human genes 0.000 description 1
- 108010032595 Antibody Binding Sites Proteins 0.000 description 1
- 102100023053 Band 4.1-like protein 5 Human genes 0.000 description 1
- 102100032412 Basigin Human genes 0.000 description 1
- 238000010207 Bayesian analysis Methods 0.000 description 1
- 102100026044 Biotinidase Human genes 0.000 description 1
- 102100021961 Bis(5'-adenosyl)-triphosphatase ENPP4 Human genes 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- -1 CAECAM Proteins 0.000 description 1
- 102100027217 CD82 antigen Human genes 0.000 description 1
- 102000015347 COP1 Human genes 0.000 description 1
- 108060001826 COP1 Proteins 0.000 description 1
- 102100030230 CUB and zona pellucida-like domain-containing protein 1 Human genes 0.000 description 1
- 102100024152 Cadherin-17 Human genes 0.000 description 1
- 102100039536 Calcium-activated chloride channel regulator 1 Human genes 0.000 description 1
- 102100039534 Calcium-activated chloride channel regulator 4 Human genes 0.000 description 1
- 102000000584 Calmodulin Human genes 0.000 description 1
- 108010041952 Calmodulin Proteins 0.000 description 1
- 102100029968 Calreticulin Human genes 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 102100030613 Carboxypeptidase A1 Human genes 0.000 description 1
- 102100035024 Carboxypeptidase B Human genes 0.000 description 1
- 108010006303 Carboxypeptidases Proteins 0.000 description 1
- 102000005367 Carboxypeptidases Human genes 0.000 description 1
- 102100024533 Carcinoembryonic antigen-related cell adhesion molecule 1 Human genes 0.000 description 1
- 102100025473 Carcinoembryonic antigen-related cell adhesion molecule 6 Human genes 0.000 description 1
- 102100032219 Cathepsin D Human genes 0.000 description 1
- 102100035654 Cathepsin S Human genes 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 102100024046 Cell adhesion molecule 3 Human genes 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 108010008951 Chemokine CXCL12 Proteins 0.000 description 1
- 102000006573 Chemokine CXCL12 Human genes 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 102100023336 Chymotrypsin-like elastase family member 3B Human genes 0.000 description 1
- 102100036486 Cobalamin binding intrinsic factor Human genes 0.000 description 1
- 102100027440 Cofilin-2 Human genes 0.000 description 1
- 108010028780 Complement C3 Proteins 0.000 description 1
- 102000016918 Complement C3 Human genes 0.000 description 1
- 102100030845 Complement component receptor 1-like protein Human genes 0.000 description 1
- 102100029386 Copine-7 Human genes 0.000 description 1
- 102100029385 Copine-9 Human genes 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- 102100028188 Cystatin-F Human genes 0.000 description 1
- 102100030497 Cytochrome c Human genes 0.000 description 1
- 241000701022 Cytomegalovirus Species 0.000 description 1
- 102100028630 Cytoskeleton-associated protein 2 Human genes 0.000 description 1
- 102100025717 Cytosolic carboxypeptidase-like protein 5 Human genes 0.000 description 1
- 102100031007 Cytosolic non-specific dipeptidase Human genes 0.000 description 1
- 102100022204 DNA-dependent protein kinase catalytic subunit Human genes 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 description 1
- 102000011799 Desmoglein Human genes 0.000 description 1
- 108050002238 Desmoglein Proteins 0.000 description 1
- 102100034578 Desmoglein-2 Human genes 0.000 description 1
- 102100028027 Double-stranded RNA-binding protein Staufen homolog 1 Human genes 0.000 description 1
- 101000652295 Drosophila melanogaster Alpha-soluble NSF attachment protein Proteins 0.000 description 1
- 102100029505 E3 ubiquitin-protein ligase TRIM33 Human genes 0.000 description 1
- 102100030081 EPM2A-interacting protein 1 Human genes 0.000 description 1
- 102000008013 Electron Transport Complex I Human genes 0.000 description 1
- 108010089760 Electron Transport Complex I Proteins 0.000 description 1
- 241000611421 Elia Species 0.000 description 1
- 102100029727 Enteropeptidase Human genes 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102100028471 Eosinophil peroxidase Human genes 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 102100039950 Eukaryotic initiation factor 4A-I Human genes 0.000 description 1
- 102100040002 Eukaryotic translation initiation factor 6 Human genes 0.000 description 1
- 102100029956 F-actin-capping protein subunit beta Human genes 0.000 description 1
- 238000004252 FT/ICR mass spectrometry Methods 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 102100020760 Ferritin heavy chain Human genes 0.000 description 1
- 102100037362 Fibronectin Human genes 0.000 description 1
- 102100026559 Filamin-B Human genes 0.000 description 1
- 102100030656 G-protein coupled receptor-associated protein LMBRD2 Human genes 0.000 description 1
- 102100030708 GTPase KRas Human genes 0.000 description 1
- 102100037777 Galactokinase Human genes 0.000 description 1
- 102000000805 Galectin 4 Human genes 0.000 description 1
- 108010001515 Galectin 4 Proteins 0.000 description 1
- 101710102083 Glutathione S-transferase 2 Proteins 0.000 description 1
- 102100033305 Glutathione S-transferase A3 Human genes 0.000 description 1
- 102100036533 Glutathione S-transferase Mu 2 Human genes 0.000 description 1
- 102100033366 Glutathione hydrolase 1 proenzyme Human genes 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 102100032610 Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas Human genes 0.000 description 1
- 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 description 1
- 102100028967 HLA class I histocompatibility antigen, alpha chain G Human genes 0.000 description 1
- 102100034684 Haloacid dehalogenase-like hydrolase domain-containing protein 3 Human genes 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 102100023919 Histone H2A.Z Human genes 0.000 description 1
- 102100038736 Histone H3.3C Human genes 0.000 description 1
- 241001272567 Hominoidea Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000818893 Homo sapiens 14-3-3 protein beta/alpha Proteins 0.000 description 1
- 101000694288 Homo sapiens 40S ribosomal protein SA Proteins 0.000 description 1
- 101000899406 Homo sapiens 45 kDa calcium-binding protein Proteins 0.000 description 1
- 101001097555 Homo sapiens 60S ribosomal protein L22 Proteins 0.000 description 1
- 101000853617 Homo sapiens 60S ribosomal protein L7 Proteins 0.000 description 1
- 101000598552 Homo sapiens Acetyl-CoA acetyltransferase, mitochondrial Proteins 0.000 description 1
- 101000936726 Homo sapiens Acid sphingomyelinase-like phosphodiesterase 3a Proteins 0.000 description 1
- 101000834207 Homo sapiens Actin, alpha skeletal muscle Proteins 0.000 description 1
- 101000728742 Homo sapiens Actin-related protein 3B Proteins 0.000 description 1
- 101000775469 Homo sapiens Adiponectin Proteins 0.000 description 1
- 101000769454 Homo sapiens Aflatoxin B1 aldehyde reductase member 3 Proteins 0.000 description 1
- 101000718028 Homo sapiens Aldo-keto reductase family 1 member C1 Proteins 0.000 description 1
- 101000799406 Homo sapiens Alpha-actinin-1 Proteins 0.000 description 1
- 101000797275 Homo sapiens Alpha-actinin-2 Proteins 0.000 description 1
- 101001128146 Homo sapiens Aminopeptidase NAALADL1 Proteins 0.000 description 1
- 101001049973 Homo sapiens Band 4.1-like protein 5 Proteins 0.000 description 1
- 101000798441 Homo sapiens Basigin Proteins 0.000 description 1
- 101000765010 Homo sapiens Beta-galactosidase Proteins 0.000 description 1
- 101000897056 Homo sapiens Bis(5'-adenosyl)-triphosphatase ENPP4 Proteins 0.000 description 1
- 101000914469 Homo sapiens CD82 antigen Proteins 0.000 description 1
- 101000726720 Homo sapiens CUB and zona pellucida-like domain-containing protein 1 Proteins 0.000 description 1
- 101000762247 Homo sapiens Cadherin-17 Proteins 0.000 description 1
- 101000888572 Homo sapiens Calcium-activated chloride channel regulator 1 Proteins 0.000 description 1
- 101000888577 Homo sapiens Calcium-activated chloride channel regulator 4 Proteins 0.000 description 1
- 101000793651 Homo sapiens Calreticulin Proteins 0.000 description 1
- 101000772551 Homo sapiens Carboxypeptidase A1 Proteins 0.000 description 1
- 101000946524 Homo sapiens Carboxypeptidase B Proteins 0.000 description 1
- 101000914326 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 6 Proteins 0.000 description 1
- 101000869010 Homo sapiens Cathepsin D Proteins 0.000 description 1
- 101000910449 Homo sapiens Cell adhesion molecule 3 Proteins 0.000 description 1
- 101000907951 Homo sapiens Chymotrypsin-like elastase family member 3B Proteins 0.000 description 1
- 101000725605 Homo sapiens Cofilin-2 Proteins 0.000 description 1
- 101000901150 Homo sapiens Collagen alpha-1(IV) chain Proteins 0.000 description 1
- 101000861874 Homo sapiens Collagen alpha-1(XII) chain Proteins 0.000 description 1
- 101000710886 Homo sapiens Collagen alpha-5(IV) chain Proteins 0.000 description 1
- 101000727057 Homo sapiens Complement component receptor 1-like protein Proteins 0.000 description 1
- 101000919214 Homo sapiens Copine-7 Proteins 0.000 description 1
- 101000919218 Homo sapiens Copine-9 Proteins 0.000 description 1
- 101000916688 Homo sapiens Cystatin-F Proteins 0.000 description 1
- 101000766848 Homo sapiens Cytoskeleton-associated protein 2 Proteins 0.000 description 1
- 101000932585 Homo sapiens Cytosolic carboxypeptidase-like protein 5 Proteins 0.000 description 1
- 101000919690 Homo sapiens Cytosolic non-specific dipeptidase Proteins 0.000 description 1
- 101000619536 Homo sapiens DNA-dependent protein kinase catalytic subunit Proteins 0.000 description 1
- 101000806149 Homo sapiens Dehydrogenase/reductase SDR family member 2, mitochondrial Proteins 0.000 description 1
- 101000924314 Homo sapiens Desmoglein-2 Proteins 0.000 description 1
- 101000697574 Homo sapiens Double-stranded RNA-binding protein Staufen homolog 1 Proteins 0.000 description 1
- 101000634991 Homo sapiens E3 ubiquitin-protein ligase TRIM33 Proteins 0.000 description 1
- 101001012120 Homo sapiens EPM2A-interacting protein 1 Proteins 0.000 description 1
- 101001012451 Homo sapiens Enteropeptidase Proteins 0.000 description 1
- 101000959666 Homo sapiens Eukaryotic initiation factor 4A-I Proteins 0.000 description 1
- 101000959746 Homo sapiens Eukaryotic translation initiation factor 6 Proteins 0.000 description 1
- 101000793778 Homo sapiens F-actin-capping protein subunit beta Proteins 0.000 description 1
- 101001002987 Homo sapiens Ferritin heavy chain Proteins 0.000 description 1
- 101001027128 Homo sapiens Fibronectin Proteins 0.000 description 1
- 101000913551 Homo sapiens Filamin-B Proteins 0.000 description 1
- 101001064250 Homo sapiens G-protein coupled receptor-associated protein LMBRD2 Proteins 0.000 description 1
- 101000584612 Homo sapiens GTPase KRas Proteins 0.000 description 1
- 101001024874 Homo sapiens Galactokinase Proteins 0.000 description 1
- 101000870590 Homo sapiens Glutathione S-transferase A3 Proteins 0.000 description 1
- 101001071691 Homo sapiens Glutathione S-transferase Mu 2 Proteins 0.000 description 1
- 101000997558 Homo sapiens Glutathione hydrolase 1 proenzyme Proteins 0.000 description 1
- 101001014590 Homo sapiens Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas Proteins 0.000 description 1
- 101001014594 Homo sapiens Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Proteins 0.000 description 1
- 101000872853 Homo sapiens Haloacid dehalogenase-like hydrolase domain-containing protein 3 Proteins 0.000 description 1
- 101000905054 Homo sapiens Histone H2A.Z Proteins 0.000 description 1
- 101001031505 Homo sapiens Histone H3.3C Proteins 0.000 description 1
- 101001055314 Homo sapiens Immunoglobulin heavy constant alpha 2 Proteins 0.000 description 1
- 101000978127 Homo sapiens Immunoglobulin lambda variable 7-46 Proteins 0.000 description 1
- 101000998629 Homo sapiens Importin subunit beta-1 Proteins 0.000 description 1
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 description 1
- 101001050470 Homo sapiens Intelectin-2 Proteins 0.000 description 1
- 101000688216 Homo sapiens Intestinal-type alkaline phosphatase Proteins 0.000 description 1
- 101000614618 Homo sapiens Junctophilin-3 Proteins 0.000 description 1
- 101001050606 Homo sapiens Ketohexokinase Proteins 0.000 description 1
- 101000971638 Homo sapiens Kinesin-like protein KIF1A Proteins 0.000 description 1
- 101001121099 Homo sapiens MICOS complex subunit MIC26 Proteins 0.000 description 1
- 101001011619 Homo sapiens MIT domain-containing protein 1 Proteins 0.000 description 1
- 101000990912 Homo sapiens Matrilysin Proteins 0.000 description 1
- 101000991619 Homo sapiens Meprin A subunit alpha Proteins 0.000 description 1
- 101000991618 Homo sapiens Meprin A subunit beta Proteins 0.000 description 1
- 101000822604 Homo sapiens Methanethiol oxidase Proteins 0.000 description 1
- 101000581272 Homo sapiens Midasin Proteins 0.000 description 1
- 101001055097 Homo sapiens Mitogen-activated protein kinase kinase kinase 6 Proteins 0.000 description 1
- 101001133081 Homo sapiens Mucin-2 Proteins 0.000 description 1
- 101000573447 Homo sapiens Multiple inositol polyphosphate phosphatase 1 Proteins 0.000 description 1
- 101000585663 Homo sapiens Myocilin Proteins 0.000 description 1
- 101001128608 Homo sapiens NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 Proteins 0.000 description 1
- 101000601056 Homo sapiens NIF3-like protein 1 Proteins 0.000 description 1
- 101001125327 Homo sapiens Na(+)/H(+) exchange regulatory cofactor NHE-RF1 Proteins 0.000 description 1
- 101001125417 Homo sapiens Na(+)/H(+) exchange regulatory cofactor NHE-RF3 Proteins 0.000 description 1
- 101001014610 Homo sapiens Neuroendocrine secretory protein 55 Proteins 0.000 description 1
- 101000578062 Homo sapiens Nicastrin Proteins 0.000 description 1
- 101001124991 Homo sapiens Nitric oxide synthase, inducible Proteins 0.000 description 1
- 101000597499 Homo sapiens Obg-like ATPase 1 Proteins 0.000 description 1
- 101000585675 Homo sapiens Obscurin Proteins 0.000 description 1
- 101000594460 Homo sapiens Olfactory receptor 2AG1 Proteins 0.000 description 1
- 101001098179 Homo sapiens P2X purinoceptor 4 Proteins 0.000 description 1
- 101001134456 Homo sapiens Pancreatic triacylglycerol lipase Proteins 0.000 description 1
- 101001124867 Homo sapiens Peroxiredoxin-1 Proteins 0.000 description 1
- 101000983077 Homo sapiens Phospholipase A2 Proteins 0.000 description 1
- 101000983161 Homo sapiens Phospholipase A2, membrane associated Proteins 0.000 description 1
- 101000801684 Homo sapiens Phospholipid-transporting ATPase ABCA1 Proteins 0.000 description 1
- 101000596041 Homo sapiens Plastin-1 Proteins 0.000 description 1
- 101001096179 Homo sapiens Pleckstrin homology domain-containing family A member 6 Proteins 0.000 description 1
- 101001134844 Homo sapiens Pre-mRNA cleavage complex 2 protein Pcf11 Proteins 0.000 description 1
- 101001088738 Homo sapiens Probable ribonuclease 11 Proteins 0.000 description 1
- 101000619345 Homo sapiens Profilin-2 Proteins 0.000 description 1
- 101001135402 Homo sapiens Prostaglandin-H2 D-isomerase Proteins 0.000 description 1
- 101000797903 Homo sapiens Protein ALEX Proteins 0.000 description 1
- 101000875512 Homo sapiens Protein FAM151A Proteins 0.000 description 1
- 101001098769 Homo sapiens Protein disulfide-isomerase A6 Proteins 0.000 description 1
- 101001051767 Homo sapiens Protein kinase C beta type Proteins 0.000 description 1
- 101000981717 Homo sapiens Protein lifeguard 3 Proteins 0.000 description 1
- 101001123047 Homo sapiens Protein phosphatase PTC7 homolog Proteins 0.000 description 1
- 101001072243 Homo sapiens Protocadherin-19 Proteins 0.000 description 1
- 101000926083 Homo sapiens Rab GDP dissociation inhibitor beta Proteins 0.000 description 1
- 101000619497 Homo sapiens Ragulator complex protein LAMTOR1 Proteins 0.000 description 1
- 101001132575 Homo sapiens Ras-related protein Rab-8B Proteins 0.000 description 1
- 101000591240 Homo sapiens Receptor-type tyrosine-protein phosphatase S Proteins 0.000 description 1
- 101000815628 Homo sapiens Regulatory-associated protein of mTOR Proteins 0.000 description 1
- 101001091999 Homo sapiens Rho GTPase-activating protein 20 Proteins 0.000 description 1
- 101000587805 Homo sapiens SPRY domain-containing protein 4 Proteins 0.000 description 1
- 101000709099 Homo sapiens Schlafen family member 5 Proteins 0.000 description 1
- 101000785063 Homo sapiens Serine-protein kinase ATM Proteins 0.000 description 1
- 101000576904 Homo sapiens Serine/threonine-protein kinase MRCK beta Proteins 0.000 description 1
- 101000868878 Homo sapiens Serpin B12 Proteins 0.000 description 1
- 101000642478 Homo sapiens Serpin B3 Proteins 0.000 description 1
- 101000836066 Homo sapiens Serpin B6 Proteins 0.000 description 1
- 101000703745 Homo sapiens Shootin-1 Proteins 0.000 description 1
- 101000740211 Homo sapiens Sodium-coupled monocarboxylate transporter 2 Proteins 0.000 description 1
- 101000716693 Homo sapiens Sodium/iodide cotransporter Proteins 0.000 description 1
- 101000753197 Homo sapiens Sodium/potassium-transporting ATPase subunit alpha-2 Proteins 0.000 description 1
- 101000923531 Homo sapiens Sodium/potassium-transporting ATPase subunit gamma Proteins 0.000 description 1
- 101000713272 Homo sapiens Solute carrier family 22 member 4 Proteins 0.000 description 1
- 101000702658 Homo sapiens Sorting nexin-18 Proteins 0.000 description 1
- 101000822540 Homo sapiens Sterile alpha motif domain-containing protein 9-like Proteins 0.000 description 1
- 101000617130 Homo sapiens Stromal cell-derived factor 1 Proteins 0.000 description 1
- 101000695537 Homo sapiens Synaptophysin-like protein 1 Proteins 0.000 description 1
- 101000820478 Homo sapiens Syntaxin-binding protein 2 Proteins 0.000 description 1
- 101000598025 Homo sapiens Talin-1 Proteins 0.000 description 1
- 101000795810 Homo sapiens Tetratricopeptide repeat protein 27 Proteins 0.000 description 1
- 101000788607 Homo sapiens Tubulin alpha-3C chain Proteins 0.000 description 1
- 101000788608 Homo sapiens Tubulin alpha-3D chain Proteins 0.000 description 1
- 101000939456 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 29 Proteins 0.000 description 1
- 101000775702 Homo sapiens V-type proton ATPase subunit C 2 Proteins 0.000 description 1
- 101000667116 Homo sapiens Vacuolar protein sorting-associated protein 13D Proteins 0.000 description 1
- 101000667188 Homo sapiens Vacuolar protein-sorting-associated protein 25 Proteins 0.000 description 1
- 101000954820 Homo sapiens WD repeat domain phosphoinositide-interacting protein 4 Proteins 0.000 description 1
- 101000666519 Homo sapiens Xaa-Pro aminopeptidase 3 Proteins 0.000 description 1
- 101000802327 Homo sapiens Zinc finger protein 561 Proteins 0.000 description 1
- 101000818517 Homo sapiens Zinc-alpha-2-glycoprotein Proteins 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- 102100027037 Hsc70-interacting protein Human genes 0.000 description 1
- 101710109065 Hsc70-interacting protein Proteins 0.000 description 1
- 241001135569 Human adenovirus 5 Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 102100026216 Immunoglobulin heavy constant alpha 2 Human genes 0.000 description 1
- 102100023751 Immunoglobulin lambda variable 7-46 Human genes 0.000 description 1
- 102100025390 Integrin beta-2 Human genes 0.000 description 1
- 102100023352 Intelectin-2 Human genes 0.000 description 1
- 108010002352 Interleukin-1 Proteins 0.000 description 1
- 108090001005 Interleukin-6 Proteins 0.000 description 1
- 102100024319 Intestinal-type alkaline phosphatase Human genes 0.000 description 1
- 102100023913 Involucrin Human genes 0.000 description 1
- 102100040488 Junctophilin-3 Human genes 0.000 description 1
- 108010062228 Karyopherins Proteins 0.000 description 1
- 102000011781 Karyopherins Human genes 0.000 description 1
- 102100023418 Ketohexokinase Human genes 0.000 description 1
- 102100021527 Kinesin-like protein KIF1A Human genes 0.000 description 1
- 102100031357 L-lactate dehydrogenase C chain Human genes 0.000 description 1
- 235000013958 Lactobacillus casei Nutrition 0.000 description 1
- 208000016604 Lyme disease Diseases 0.000 description 1
- 108091054455 MAP kinase family Proteins 0.000 description 1
- 102000043136 MAP kinase family Human genes 0.000 description 1
- 102100030158 MIT domain-containing protein 1 Human genes 0.000 description 1
- 108090000855 Matrilysin Proteins 0.000 description 1
- 102100030882 Meprin A subunit alpha Human genes 0.000 description 1
- 108010006035 Metalloproteases Proteins 0.000 description 1
- 102000005741 Metalloproteases Human genes 0.000 description 1
- 102100022465 Methanethiol oxidase Human genes 0.000 description 1
- 102000029749 Microtubule Human genes 0.000 description 1
- 108091022875 Microtubule Proteins 0.000 description 1
- 102100027666 Midasin Human genes 0.000 description 1
- 102100026889 Mitogen-activated protein kinase kinase kinase 6 Human genes 0.000 description 1
- 101150097381 Mtor gene Proteins 0.000 description 1
- 102100034263 Mucin-2 Human genes 0.000 description 1
- 206010028116 Mucosal inflammation Diseases 0.000 description 1
- 201000010927 Mucositis Diseases 0.000 description 1
- 102100026284 Multiple inositol polyphosphate phosphatase 1 Human genes 0.000 description 1
- 102100029839 Myocilin Human genes 0.000 description 1
- 102100030856 Myoglobin Human genes 0.000 description 1
- 108010062374 Myoglobin Proteins 0.000 description 1
- 102100032205 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 Human genes 0.000 description 1
- 102100037380 NIF3-like protein 1 Human genes 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 102100029447 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 Human genes 0.000 description 1
- 102100029467 Na(+)/H(+) exchange regulatory cofactor NHE-RF3 Human genes 0.000 description 1
- 108020001621 Natriuretic Peptide Proteins 0.000 description 1
- 102000004571 Natriuretic peptide Human genes 0.000 description 1
- 102100021867 Natural resistance-associated macrophage protein 2 Human genes 0.000 description 1
- 102000012106 Neutral Amino Acid Transport Systems Human genes 0.000 description 1
- 108010036505 Neutral Amino Acid Transport Systems Proteins 0.000 description 1
- 102100028056 Nicastrin Human genes 0.000 description 1
- 102100029438 Nitric oxide synthase, inducible Human genes 0.000 description 1
- 102100025062 Nucleosome-remodeling factor subunit BPTF Human genes 0.000 description 1
- 102100035415 Obg-like ATPase 1 Human genes 0.000 description 1
- 101710194880 Obscurin Proteins 0.000 description 1
- 102100035514 Olfactory receptor 2AG1 Human genes 0.000 description 1
- 206010031252 Osteomyelitis Diseases 0.000 description 1
- 108010035042 Osteoprotegerin Proteins 0.000 description 1
- 102000008108 Osteoprotegerin Human genes 0.000 description 1
- 102100037601 P2X purinoceptor 4 Human genes 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 102100024019 Pancreatic secretory granule membrane major glycoprotein GP2 Human genes 0.000 description 1
- 102100033359 Pancreatic triacylglycerol lipase Human genes 0.000 description 1
- 208000031816 Pathologic Dilatation Diseases 0.000 description 1
- 102100029139 Peroxiredoxin-1 Human genes 0.000 description 1
- 102100037392 Phosphoglycerate kinase 2 Human genes 0.000 description 1
- 102100026918 Phospholipase A2 Human genes 0.000 description 1
- 102100026831 Phospholipase A2, membrane associated Human genes 0.000 description 1
- 229940124154 Phospholipase inhibitor Drugs 0.000 description 1
- 102100033616 Phospholipid-transporting ATPase ABCA1 Human genes 0.000 description 1
- 102100035181 Plastin-1 Human genes 0.000 description 1
- 102100037869 Pleckstrin homology domain-containing family A member 6 Human genes 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 102100033427 Pre-mRNA cleavage complex 2 protein Pcf11 Human genes 0.000 description 1
- 102100033987 Probable ribonuclease 11 Human genes 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 102100022555 Profilin-2 Human genes 0.000 description 1
- 102100033279 Prostaglandin-H2 D-isomerase Human genes 0.000 description 1
- 102100035994 Protein FAM151A Human genes 0.000 description 1
- 102100037061 Protein disulfide-isomerase A6 Human genes 0.000 description 1
- 102100024136 Protein lifeguard 3 Human genes 0.000 description 1
- 102100028557 Protein phosphatase PTC7 homolog Human genes 0.000 description 1
- 102100036389 Protocadherin-19 Human genes 0.000 description 1
- 102100034328 Rab GDP dissociation inhibitor beta Human genes 0.000 description 1
- 102100022151 Ragulator complex protein LAMTOR1 Human genes 0.000 description 1
- 102100033959 Ras-related protein Rab-8B Human genes 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 102100040969 Regulatory-associated protein of mTOR Human genes 0.000 description 1
- 206010061481 Renal injury Diseases 0.000 description 1
- 102000018779 Replication Protein C Human genes 0.000 description 1
- 108010027647 Replication Protein C Proteins 0.000 description 1
- 241000219061 Rheum Species 0.000 description 1
- 102100035751 Rho GTPase-activating protein 20 Human genes 0.000 description 1
- 108010053823 Rho Guanine Nucleotide Exchange Factors Proteins 0.000 description 1
- 108091006207 SLC-Transporter Proteins 0.000 description 1
- 102000037054 SLC-Transporter Human genes 0.000 description 1
- 108091006618 SLC11A2 Proteins 0.000 description 1
- 108091006626 SLC12A7 Proteins 0.000 description 1
- 108091006208 SLC3 Proteins 0.000 description 1
- 102100031124 SPRY domain-containing protein 4 Human genes 0.000 description 1
- 102100032668 Schlafen family member 5 Human genes 0.000 description 1
- 102100023152 Scinderin Human genes 0.000 description 1
- 102100020824 Serine-protein kinase ATM Human genes 0.000 description 1
- 102100025347 Serine/threonine-protein kinase MRCK beta Human genes 0.000 description 1
- 102100023085 Serine/threonine-protein kinase mTOR Human genes 0.000 description 1
- 102100032321 Serpin B12 Human genes 0.000 description 1
- 102100036383 Serpin B3 Human genes 0.000 description 1
- 102100025512 Serpin B6 Human genes 0.000 description 1
- 102100031975 Shootin-1 Human genes 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 108010074941 Sodium-Potassium-Chloride Symporters Proteins 0.000 description 1
- 102000008145 Sodium-Potassium-Chloride Symporters Human genes 0.000 description 1
- 102100037203 Sodium-coupled monocarboxylate transporter 2 Human genes 0.000 description 1
- 102100020886 Sodium/iodide cotransporter Human genes 0.000 description 1
- 102100021955 Sodium/potassium-transporting ATPase subunit alpha-2 Human genes 0.000 description 1
- 102100034351 Sodium/potassium-transporting ATPase subunit gamma Human genes 0.000 description 1
- 102100034252 Solute carrier family 12 member 7 Human genes 0.000 description 1
- 102100036804 Solute carrier family 13 member 2 Human genes 0.000 description 1
- 102100021493 Solute carrier family 22 member 11 Human genes 0.000 description 1
- 102100036928 Solute carrier family 22 member 4 Human genes 0.000 description 1
- 102100032889 Sortilin Human genes 0.000 description 1
- 102100030997 Sorting nexin-18 Human genes 0.000 description 1
- 102100022459 Sterile alpha motif domain-containing protein 9-like Human genes 0.000 description 1
- 108010057517 Strep-avidin conjugated horseradish peroxidase Proteins 0.000 description 1
- 102100021669 Stromal cell-derived factor 1 Human genes 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 102100028532 Synaptophysin-like protein 1 Human genes 0.000 description 1
- 102100024174 Syntaxin-7 Human genes 0.000 description 1
- 102100021680 Syntaxin-binding protein 2 Human genes 0.000 description 1
- 102100036977 Talin-1 Human genes 0.000 description 1
- 102100031763 Tetratricopeptide repeat protein 27 Human genes 0.000 description 1
- 102100031142 Transcriptional repressor protein YY1 Human genes 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 102000004271 Tryptophan 5-monooxygenases Human genes 0.000 description 1
- 108090000885 Tryptophan 5-monooxygenases Proteins 0.000 description 1
- 102100025235 Tubulin alpha-3C chain Human genes 0.000 description 1
- 102100025236 Tubulin alpha-3D chain Human genes 0.000 description 1
- 108091000117 Tyrosine 3-Monooxygenase Proteins 0.000 description 1
- 102000048218 Tyrosine 3-monooxygenases Human genes 0.000 description 1
- 102100029818 Ubiquitin carboxyl-terminal hydrolase 29 Human genes 0.000 description 1
- 102100031834 Unconventional myosin-VI Human genes 0.000 description 1
- 102100032185 V-type proton ATPase subunit C 2 Human genes 0.000 description 1
- 102100039110 Vacuolar protein sorting-associated protein 13D Human genes 0.000 description 1
- 102100039080 Vacuolar protein-sorting-associated protein 25 Human genes 0.000 description 1
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 1
- 102100039037 Vascular endothelial growth factor A Human genes 0.000 description 1
- 102100037048 WD repeat domain phosphoinositide-interacting protein 4 Human genes 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 102100038359 Xaa-Pro aminopeptidase 3 Human genes 0.000 description 1
- 102100034643 Zinc finger protein 561 Human genes 0.000 description 1
- 102100021144 Zinc-alpha-2-glycoprotein Human genes 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 208000037881 acute idiopathic vasculitis Diseases 0.000 description 1
- 230000033289 adaptive immune response Effects 0.000 description 1
- 208000013228 adenopathy Diseases 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 210000004381 amniotic fluid Anatomy 0.000 description 1
- 230000030741 antigen processing and presentation Effects 0.000 description 1
- 239000012062 aqueous buffer Substances 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 210000003567 ascitic fluid Anatomy 0.000 description 1
- 238000003149 assay kit Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 238000013477 bayesian statistics method Methods 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 238000005415 bioluminescence Methods 0.000 description 1
- 230000029918 bioluminescence Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000000738 capillary electrophoresis-mass spectrometry Methods 0.000 description 1
- 210000004413 cardiac myocyte Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 239000013592 cell lysate Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 208000011902 cervical lymphadenopathy Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000008077 compensatory immune mechanism Effects 0.000 description 1
- 238000012875 competitive assay Methods 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000009918 complex formation Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 208000006331 coronary aneurysm Diseases 0.000 description 1
- 230000003436 cytoskeletal effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000000104 diagnostic biomarker Substances 0.000 description 1
- 238000007435 diagnostic evaluation Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000002592 echocardiography Methods 0.000 description 1
- 229940124645 emergency medicine Drugs 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 238000007421 fluorometric assay Methods 0.000 description 1
- 108010022687 fumarylacetoacetase Proteins 0.000 description 1
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 1
- 102000009543 guanyl-nucleotide exchange factor activity proteins Human genes 0.000 description 1
- 230000035931 haemagglutination Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000011544 high accuracy mass spectrometry proteome profiling Methods 0.000 description 1
- 238000004896 high resolution mass spectrometry Methods 0.000 description 1
- 238000011543 high-accuracy mass spectrometry proteomics Methods 0.000 description 1
- 230000008076 immune mechanism Effects 0.000 description 1
- 230000008073 immune recognition Effects 0.000 description 1
- 238000003365 immunocytochemistry Methods 0.000 description 1
- 238000011532 immunohistochemical staining Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011337 individualized treatment Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000015788 innate immune response Effects 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 208000037806 kidney injury Diseases 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 229940017800 lactobacillus casei Drugs 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 1
- 238000001294 liquid chromatography-tandem mass spectrometry Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004880 lymph fluid Anatomy 0.000 description 1
- 208000018555 lymphatic system disease Diseases 0.000 description 1
- 230000002132 lysosomal effect Effects 0.000 description 1
- 102000004356 mRNA Cleavage and Polyadenylation Factors Human genes 0.000 description 1
- 108010042176 mRNA Cleavage and Polyadenylation Factors Proteins 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 108700021856 member 2 solute carrier family 11- (proton-coupled divalent metal ion transporters) Proteins 0.000 description 1
- 210000003632 microfilament Anatomy 0.000 description 1
- 210000004688 microtubule Anatomy 0.000 description 1
- 230000004784 molecular pathogenesis Effects 0.000 description 1
- 210000005087 mononuclear cell Anatomy 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 230000008066 mucocutaneous inflammation Effects 0.000 description 1
- 230000008065 myocardial cell damage Effects 0.000 description 1
- 208000037891 myocardial injury Diseases 0.000 description 1
- 210000000107 myocyte Anatomy 0.000 description 1
- 108010049787 myosin VI Proteins 0.000 description 1
- 238000005319 nano flow HPLC Methods 0.000 description 1
- 239000000692 natriuretic peptide Substances 0.000 description 1
- 238000013188 needle biopsy Methods 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000036963 noncompetitive effect Effects 0.000 description 1
- 239000000101 novel biomarker Substances 0.000 description 1
- XXUPLYBCNPLTIW-UHFFFAOYSA-N octadec-7-ynoic acid Chemical compound CCCCCCCCCCC#CCCCCCC(O)=O XXUPLYBCNPLTIW-UHFFFAOYSA-N 0.000 description 1
- 238000001543 one-way ANOVA Methods 0.000 description 1
- 230000003950 pathogenic mechanism Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000008068 pathophysiological alteration Effects 0.000 description 1
- 230000001991 pathophysiological effect Effects 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000003428 phospholipase inhibitor Substances 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 238000012123 point-of-care testing Methods 0.000 description 1
- 102000054765 polymorphisms of proteins Human genes 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 208000030279 prolonged fever Diseases 0.000 description 1
- 230000006920 protein precipitation Effects 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000012898 sample dilution Substances 0.000 description 1
- 108010078070 scavenger receptors Proteins 0.000 description 1
- 102000014452 scavenger receptors Human genes 0.000 description 1
- 206010040400 serum sickness Diseases 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 108010014657 sortilin Proteins 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000000528 statistical test Methods 0.000 description 1
- 238000013517 stratification Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000000672 surface-enhanced laser desorption--ionisation Methods 0.000 description 1
- 108010008054 testis specific phosphoglycerate kinase Proteins 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 231100000216 vascular lesion Toxicity 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96486—Metalloendopeptidases (3.4.24)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/328—Vasculitis, i.e. inflammation of blood vessels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161475936P | 2011-04-15 | 2011-04-15 | |
| US61/475,936 | 2011-04-15 | ||
| US201161579007P | 2011-12-22 | 2011-12-22 | |
| US61/579,007 | 2011-12-22 | ||
| PCT/US2012/033514 WO2012142409A2 (en) | 2011-04-15 | 2012-04-13 | Diagnostic markers and therapeutic targets of kawasaki disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2833257A1 true CA2833257A1 (en) | 2012-10-18 |
Family
ID=46208753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2833257A Abandoned CA2833257A1 (en) | 2011-04-15 | 2012-04-13 | Diagnostic markers and therapeutic targets of kawasaki disease |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9869673B2 (enExample) |
| EP (2) | EP3086121A1 (enExample) |
| JP (1) | JP6072768B2 (enExample) |
| KR (1) | KR20140034193A (enExample) |
| CN (2) | CN103562725B (enExample) |
| AU (1) | AU2012242684B2 (enExample) |
| CA (1) | CA2833257A1 (enExample) |
| WO (1) | WO2012142409A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015168602A2 (en) * | 2014-05-02 | 2015-11-05 | Momenta Pharmaceuticals, Inc. | Methods and compositions for the diagnosis and treatment of kawasaki disease |
| JP6779200B2 (ja) | 2014-07-24 | 2020-11-04 | アカデミア シニカ | 川崎病の診断及び治療 |
| KR102056405B1 (ko) * | 2018-04-05 | 2019-12-16 | (주)메디젠휴먼케어 | Ebf2 유전자 다형성을 이용한 가와사키병 발병 예측 방법 |
| CN110763845B (zh) * | 2018-07-27 | 2022-10-28 | 成都市第三人民医院 | 一种检测蛋白标志物的配体在制备用于诊断结肠癌的产品中的用途和试剂盒 |
| TWI704349B (zh) * | 2019-06-17 | 2020-09-11 | 高雄榮民總醫院 | 蛋白質生物標記用以診斷川崎症的用途 |
| US20240263234A1 (en) * | 2020-10-02 | 2024-08-08 | Mitsuru MIYATO | Method for predicting development of severe symptom of covid-19 using exosomal protein marker in blood |
| CN113267626B (zh) * | 2021-05-17 | 2023-01-13 | 郑州大学第一附属医院 | 一种用于高危人群贲门腺癌早期筛查的试纸条 |
| KR102705469B1 (ko) * | 2022-05-30 | 2024-09-11 | 충남대학교산학협력단 | 불응성 가와사키병의 감별 진단을 위한 정보 제공 방법 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6406921B1 (en) | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
| US7429466B2 (en) | 2000-01-24 | 2008-09-30 | Hypromatrix, Inc | Methods and arrays for detecting biological molecules |
| US6905827B2 (en) * | 2001-06-08 | 2005-06-14 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases |
| US7112408B2 (en) | 2001-06-08 | 2006-09-26 | The Brigham And Women's Hospital, Inc. | Detection of ovarian cancer based upon alpha-haptoglobin levels |
| US20030013208A1 (en) | 2001-07-13 | 2003-01-16 | Milagen, Inc. | Information enhanced antibody arrays |
| WO2007003594A1 (en) | 2005-07-01 | 2007-01-11 | Solvay Pharmaceuticals Gmbh | Screening methods for inhibitors of the metalloprotease meprin |
| JP4795037B2 (ja) | 2006-02-01 | 2011-10-19 | 財団法人 神戸市地域医療振興財団 | 川崎病の判定方法及びそのためのキット |
| EP2028492A4 (en) | 2006-06-05 | 2009-06-10 | Shimadzu Corp | TUMOR MARKERS AND METHOD FOR DETERMINING THE IMPACT OF ANY CANNULAR DISEASE |
| EP2057465A4 (en) | 2006-08-09 | 2010-04-21 | Homestead Clinical Corp | ORGANIC PROTEINS AND METHOD OF USE THEREOF |
| US20090093005A1 (en) * | 2007-10-05 | 2009-04-09 | University Of Virginia Patent Foundation | Protein-based biomarkers for abdominal aortic aneurysm |
| US20110311443A1 (en) * | 2009-03-06 | 2011-12-22 | Klaus Tschira Stiftung Ggmbh | Pharmaceutical composition and method for identifying a cancerous and/or an inflammatory disease in a patient |
-
2012
- 2012-04-13 WO PCT/US2012/033514 patent/WO2012142409A2/en not_active Ceased
- 2012-04-13 EP EP16162648.6A patent/EP3086121A1/en not_active Withdrawn
- 2012-04-13 EP EP12725900.0A patent/EP2697653B1/en not_active Not-in-force
- 2012-04-13 KR KR1020137030334A patent/KR20140034193A/ko not_active Withdrawn
- 2012-04-13 CA CA2833257A patent/CA2833257A1/en not_active Abandoned
- 2012-04-13 CN CN201280024575.6A patent/CN103562725B/zh not_active Expired - Fee Related
- 2012-04-13 AU AU2012242684A patent/AU2012242684B2/en not_active Expired - Fee Related
- 2012-04-13 CN CN201610498798.6A patent/CN106053835A/zh active Pending
- 2012-04-13 US US14/111,816 patent/US9869673B2/en not_active Expired - Fee Related
- 2012-04-13 JP JP2014505335A patent/JP6072768B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20140161791A1 (en) | 2014-06-12 |
| CN106053835A (zh) | 2016-10-26 |
| CN103562725B (zh) | 2016-08-17 |
| AU2012242684A1 (en) | 2013-10-31 |
| EP2697653B1 (en) | 2016-03-30 |
| CN103562725A (zh) | 2014-02-05 |
| JP6072768B2 (ja) | 2017-02-01 |
| AU2012242684B2 (en) | 2017-04-20 |
| US9869673B2 (en) | 2018-01-16 |
| EP2697653A2 (en) | 2014-02-19 |
| JP2014512014A (ja) | 2014-05-19 |
| WO2012142409A3 (en) | 2013-02-28 |
| WO2012142409A2 (en) | 2012-10-18 |
| EP3086121A1 (en) | 2016-10-26 |
| KR20140034193A (ko) | 2014-03-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2012242684B2 (en) | Diagnostic markers and therapeutic targets of Kawasaki disease | |
| Øvrehus et al. | Urinary proteomics in chronic kidney disease: diagnosis and risk of progression beyond albuminuria | |
| US11041867B2 (en) | ProADM and/or histones as markers indicating an adverse event | |
| WO2021076036A1 (en) | Apparatuses and methods for detection of pancreatic cancer | |
| CN109564225B (zh) | 作为指示不良事件的标志物的组蛋白和/或proADM | |
| JP2012516445A (ja) | 体液における新生児敗血症の検出のためのバイオマーカー | |
| US20130116343A1 (en) | Salivary Protein Markers for Detection of Breast Cancer | |
| EP2153233A1 (en) | Method for predicting the outcome of a critically ill patient | |
| US20110269162A1 (en) | Ubiquitin proteasome system profiling for diagnosis of chronic liver disease | |
| US20110256169A1 (en) | Novel polypeptides related to b-type natriuretic peptides and methods of their identification and use | |
| US7871787B2 (en) | Methods for diagnosing endometriosis | |
| KR20200080183A (ko) | 치주질환 진단 방법, 이를 위한 조성물 및 키트 | |
| Verma et al. | Procalcitonin as a predictor of survival in patients with sepsis: A study on diagnostic accuracy | |
| RU2775090C2 (ru) | Проадреномедуллин в качестве маркера, указывающего на неблагоприятное событие | |
| 정영화 | Proteomic identification of early urinary-biomarkers of acute kidney injury in preterm infants | |
| HK1193650A (en) | Diagnostic markers and therapeutic targets of kawasaki disease | |
| CN120712476A (zh) | 胰腺癌检测 | |
| Raziq et al. | Correlating Serum Biomarkers with Clinical Outcomes in Pediatric Sepsis; A Retrospective Observational Study | |
| HK40017069A (en) | Proadm as marker indicating an adverse event |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20180413 |