CN106046167A - 结合Dll4和Ang2的双特异性结合分子 - Google Patents

结合Dll4和Ang2的双特异性结合分子 Download PDF

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Publication number
CN106046167A
CN106046167A CN201610374703.XA CN201610374703A CN106046167A CN 106046167 A CN106046167 A CN 106046167A CN 201610374703 A CN201610374703 A CN 201610374703A CN 106046167 A CN106046167 A CN 106046167A
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CN
China
Prior art keywords
dll4
vhh
ang2
immunoglobulin
variable domain
Prior art date
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Pending
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CN201610374703.XA
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English (en)
Chinese (zh)
Inventor
A.格希文德
R.G.奥特
J.博克尼奥
M-A.拜西
E.德普拉
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Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44314095&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN106046167(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of CN106046167A publication Critical patent/CN106046167A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201610374703.XA 2011-04-01 2012-03-30 结合Dll4和Ang2的双特异性结合分子 Pending CN106046167A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11160920.2 2011-04-01
EP11160920 2011-04-01
CN201280026737.XA CN103596977B (zh) 2011-04-01 2012-03-30 结合D114和Ang2的双特异性结合分子

Related Parent Applications (1)

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CN201280026737.XA Division CN103596977B (zh) 2011-04-01 2012-03-30 结合D114和Ang2的双特异性结合分子

Publications (1)

Publication Number Publication Date
CN106046167A true CN106046167A (zh) 2016-10-26

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ID=44314095

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CN201610374703.XA Pending CN106046167A (zh) 2011-04-01 2012-03-30 结合Dll4和Ang2的双特异性结合分子
CN201280026737.XA Expired - Fee Related CN103596977B (zh) 2011-04-01 2012-03-30 结合D114和Ang2的双特异性结合分子

Family Applications After (1)

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CN201280026737.XA Expired - Fee Related CN103596977B (zh) 2011-04-01 2012-03-30 结合D114和Ang2的双特异性结合分子

Country Status (23)

Country Link
US (1) US20130078247A1 (https=)
EP (1) EP2694545B1 (https=)
JP (1) JP2014511682A (https=)
KR (1) KR20140016345A (https=)
CN (2) CN106046167A (https=)
AP (1) AP2013007086A0 (https=)
AR (1) AR085919A1 (https=)
AU (1) AU2012234218A1 (https=)
BR (1) BR112013025294A2 (https=)
CA (1) CA2827809A1 (https=)
CL (1) CL2013002622A1 (https=)
CO (1) CO6801638A2 (https=)
EA (1) EA201301109A1 (https=)
EC (1) ECSP13012996A (https=)
MA (1) MA35233B1 (https=)
MX (1) MX337115B (https=)
PE (1) PE20141157A1 (https=)
PH (1) PH12013502031A1 (https=)
SG (1) SG193557A1 (https=)
TN (1) TN2013000389A1 (https=)
TW (2) TWI535735B (https=)
UY (1) UY33997A (https=)
WO (1) WO2012131076A1 (https=)

Cited By (2)

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Publication number Priority date Publication date Assignee Title
CN107540747A (zh) * 2017-08-09 2018-01-05 苏州大学附属儿童医院 抗人dll4单克隆抗体6f12
WO2025111816A1 (en) * 2023-11-28 2025-06-05 Eluminex Biosciences Limited Multispecific fusion proteins targeting angiogenic, inflammatory, and/or fibrotic factors

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US9527925B2 (en) 2011-04-01 2016-12-27 Boehringer Ingelheim International Gmbh Bispecific binding molecules binding to VEGF and ANG2
SI2831111T1 (sl) * 2012-03-30 2019-06-28 Boehringer Ingelheim International Gmbh Ang2-vezavne molekule
KR20150060686A (ko) * 2012-09-28 2015-06-03 베링거 인겔하임 인터내셔날 게엠베하 이중 안지오포이에틴-2/Dll4 결합제 및 항-VEGF 제제를 포함하는 약제학적 조합물
JP2015532272A (ja) * 2012-09-28 2015-11-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 二重アンジオポエチン−２／Ｄｌｌ４結合剤および抗ＶＥＧＦ−Ｒ剤を含む薬学的組み合わせ
ES2913205T3 (es) 2014-05-13 2022-06-01 Bioatla Inc Proteínas biológicas activas condicionalmente
CN110950967B (zh) * 2019-12-13 2022-05-13 山东民康生物科技有限公司 抗人血清白蛋白纳米抗体与il-2融合蛋白及制备方法
CA3231417A1 (en) * 2021-09-10 2023-03-16 Jian Shi Anti-ang2 antibody, preparation method therefor, and application thereof
CN116444675B (zh) * 2023-05-11 2023-12-22 亲和(武汉)生命科技有限责任公司 一种Pfu DNA聚合酶纳米抗体及其制备方法和应用

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US20100196385A1 (en) * 2008-09-19 2010-08-05 Medlmmune Llc Targeted binding agents directed to dll4 and uses thereof 524
WO2011014469A1 (en) * 2009-07-29 2011-02-03 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human angiopoietin-2

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UY32917A (es) * 2009-10-02 2011-04-29 Boehringer Ingelheim Int Moléculas de unión a dll-4
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Publication number Priority date Publication date Assignee Title
CN101489576A (zh) * 2006-06-06 2009-07-22 健泰科生物技术公司 用于调节血管发育的组合物和方法
US20100196385A1 (en) * 2008-09-19 2010-08-05 Medlmmune Llc Targeted binding agents directed to dll4 and uses thereof 524
WO2011014469A1 (en) * 2009-07-29 2011-02-03 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human angiopoietin-2

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107540747A (zh) * 2017-08-09 2018-01-05 苏州大学附属儿童医院 抗人dll4单克隆抗体6f12
CN107540747B (zh) * 2017-08-09 2020-01-24 苏州大学附属儿童医院 抗人dll4单克隆抗体6f12
WO2025111816A1 (en) * 2023-11-28 2025-06-05 Eluminex Biosciences Limited Multispecific fusion proteins targeting angiogenic, inflammatory, and/or fibrotic factors

Also Published As

Publication number Publication date
KR20140016345A (ko) 2014-02-07
WO2012131076A1 (en) 2012-10-04
MX2013011032A (es) 2013-12-06
TW201302789A (zh) 2013-01-16
MX337115B (es) 2016-02-12
EP2694545A1 (en) 2014-02-12
CA2827809A1 (en) 2012-10-04
CN103596977B (zh) 2016-07-06
AU2012234218A1 (en) 2013-09-05
BR112013025294A2 (pt) 2017-06-13
AR085919A1 (es) 2013-11-06
NZ614243A (en) 2015-04-24
JP2014511682A (ja) 2014-05-19
CN103596977A (zh) 2014-02-19
MA35233B1 (fr) 2014-07-03
UY33997A (es) 2012-09-28
SG193557A1 (en) 2013-11-29
TWI535735B (zh) 2016-06-01
TW201302797A (zh) 2013-01-16
CO6801638A2 (es) 2013-11-29
TN2013000389A1 (en) 2015-01-20
TWI551612B (zh) 2016-10-01
ECSP13012996A (es) 2013-12-31
AP2013007086A0 (en) 2013-08-31
PH12013502031A1 (en) 2013-12-16
CL2013002622A1 (es) 2014-02-14
US20130078247A1 (en) 2013-03-28
PE20141157A1 (es) 2014-09-24
EA201301109A1 (ru) 2014-08-29
EP2694545B1 (en) 2016-08-24

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