CN106035361A - Compound quaternary ammonium salt disinfection solution, and preparation method and application thereof - Google Patents
Compound quaternary ammonium salt disinfection solution, and preparation method and application thereof Download PDFInfo
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- CN106035361A CN106035361A CN201610340134.7A CN201610340134A CN106035361A CN 106035361 A CN106035361 A CN 106035361A CN 201610340134 A CN201610340134 A CN 201610340134A CN 106035361 A CN106035361 A CN 106035361A
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- quaternary ammonium
- disinfectant solution
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
- A01N43/08—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings with oxygen as the ring hetero atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
Abstract
The invention discloses a quaternary ammonium salt disinfection solution, and a preparation method and application thereof. The quaternary ammonium salt disinfection solution comprises the following components: hexamethylenetetramine, benzalkonium bromide, benzalkonium chloride, polyhexamethylene guanidine, Tween 80, octadecyldimethylbenzyl chloride, isopropanol and sterile water. The invention further discloses a method for preparing the disinfection solution. According to the invention, hexamethylenetetramine, benzalkonium bromide, benzalkonium chloride, polyhexamethylene guanidine, octadecyldimethylbenzyl chloride and Tween 80 are combined together according to a specific mixing proportion, and the components have synergistic effects, so a variety of disadvantages of a single disinfectant variety or a simply-mixed disinfectant are overcome, and a variety of bacteria, fungi, spores and viruses can be thoroughly killed; meanwhile, the disinfection solution is safe to human body, is free of toxicity and stimulation, is convenient to use, can be directly used by being diluted with water, realizes one-step completion of disinfection and cleaning, has no corrosion to equipment and no harm on the environment, and is biodegradable.
Description
Technical field
The present invention relates to a kind of disinfectant solution, particularly relate to a kind of complex quaternary ammonium salts disinfectant solution and preparation method thereof, the present invention
Further to the application in terms of sterilization and cleaning of this complex quaternary ammonium salts disinfectant solution, belong to the neck of complex quaternary ammonium salts disinfectant solution
Territory.
Background technology
Current sterile products and cleaning product major part are single use, although can ensure that sterilization and clean effect
Really, not only operate with complex steps, and the various lacuna of existence in various degree:
The most frequently used disinfectant is mostly chlorine, bromine, iodine or the compound of corresponding releasable halogen.This type of disinfectant consumption
Maximum is chlorine, owing to raw material is easy to get, easily prepares, low price, and bactericidal action is reliable, is therefore used widely；But
This type of disinfectant existence and stability is poor, aqueous solution is in the defect such as acid, the bactericidal action persistent period is short.
Peroxide is also a class Application comparison disinfection composition widely, mainly has hydrogen peroxide (hydrogen peroxide), peroxide second
Acid, Peroxycaprylic acid etc.；Wherein, the most familiar is exactly hydrogen peroxide, can be killed by the most obstinate anthrax spores, to shuttle
Shape bacillus cereus also has good killing action；But the impact of temperature, pH value and heavy metal can make it lose activity, Er Qieqi
Incomplete chemical reaction can be produced with most of materials.
The populated with of cell membrane is preferably acted on by neutral quarternary ammonium salt compound due to its active tension, has certain killing
Bacterium effect, and highly stable, but its significant cationic characteristic determines and produces antagonism with anionic species, thus lose
Lose bactericidal action.
Aldehydes is a kind of widely applicable disinfectant, has been used for the most many sterilizations, the bactericidal range bag of its broadness
Including antibacterial, mycete, yeast, virus and spore, fungicidal effectiveness is hardly by protein or the like institute shadow
Ringing, the solution-stabilized phase is long, but its obvious toxicity and zest add again people's worry to safety.
Conventional abluent is anion surfactant and nonionic surfactant.Anion surfactant has
The feature such as strong detergency, low cost, but its aqueous solution is alkalescence, all has antagonism with acidic materials and cationic substance.And
Nonionic surfactant and acidic materials and cationic substance are almost without antagonism.
In a word, existing disinfectant and abluent are each with obvious pluses and minuses, only to different chemistry
Composition carries out compounding the balance that just can reach more satisfactory between cleaning and bactericidal properties
Summary of the invention
It is an object of the invention to overcome existing single quaternary ammonium salt disinfectant solution and be simply mixed existing for disinfectant solution not
Foot, it is provided that a kind of safe to the human body, nontoxic, harmless, non-stimulated；Corrosion-free to equipment；Environmentally safe, degradable；Sterilization
Clean the complex quaternary ammonium salts disinfectant solution synchronously completed.
For reaching above-mentioned purpose, the invention provides a kind of complex quaternary ammonium salts disinfectant solution, including: hexamethylenetetramine, benzene
Prick bromine ammonium, benzalkonium chloride, polyhexamethylene guanidine, Tween 80, octadecyl dimethyl benzyl part chloride, isopropanol and aseptic
Water.
The present invention is found through experiments, and when each component carries out proportioning according to following weight portion, can reach preferably to sterilize
Cleaning performance:
Hexamethylenetetramine 25～33 parts, benzalkonium bromide 8～10 parts, benzalkonium chloride 1～2 parts, polyhexamethylene guanidine 0.5～
2 parts, Tween 80 0.3～2 parts, octadecyl dimethyl benzyl part chloride 0.5～6 parts, isopropanol 0.5～2 parts, sterilized water 43
～64.2 parts.
It is furthermore preferred that the weight portion of each component is: hexamethylenetetramine 29 parts, benzalkonium bromide 9 parts, benzalkonium chloride 1.25
Part, polyhexamethylene guanidine 1.25 parts, octadecyl dimethyl benzyl part chloride 3.25 parts, isopropanol 1.25 parts, sterilized water
54.85 parts.
Another object of the present invention is to provide a kind of method preparing described complex quaternary ammonium salts disinfectant solution, including following
Step:
(1) each component is weighed according to described weight proportion；
(2) first by hexamethylenetetramine, benzalkonium bromide, benzalkonium chloride, polyhexamethylene guanidine, octadecyl dimethyl benzyl
Part chloride, Tween 80 and sterilized water mix and blend；Mixture after stirring is joined in reactor；
(3) propanol is joined in reactor it is sufficiently stirred for mixture, stands, filters, detects, fill and get final product.
In order to realize more preferable effect, the stirring described in step (1) can be to mix under room temperature, condition of normal pressure
Stirring；Described normal temperature condition can be 18～32 DEG C, and the pressure of described condition of normal pressure can be 100KPa～101KPa；Preferably
, described mixing time is 1～2 hour, and blender rotating speed is preferably 100～110 revs/min.
Stirring described in step (2) can also be to carry out mix and blend under room temperature, condition of normal pressure；Described normal temperature condition
Can be 18～32 DEG C, the pressure of described condition of normal pressure can be 100KPa～101KPa；Preferably, described mixing time is
4～6 hours, blender rotating speed was preferably 500～510 revs/min.
Standing (aging) time described in step (3) is preferably 10～12 hours.
The present invention is by hexamethylenetetramine, benzalkonium bromide, benzalkonium chloride, polyhexamethylene guanidine, octadecyldimethyl benzyl
Substrate chloride and Tween 80, according to together with specific consumption proportion compatibility, by synergism between each component, overcome
Single variety or be simply mixed the various defects of disinfectant of preparation, safe to the human body, nontoxic, non-stimulated.To equipment without corruption
Erosion, environmental sound, degradable.Easy to use, direct dilute with water can use, and sterilization is cleaned and once completed.
After testing, 1: 100 diluent of disinfectant solution of the present invention can effectively kill pathogenic entero becteria, suppurative in 5 minutes
Coccus, saccharomytes；Disinfectant solution of the present invention can effective inactivated avian influenza virus；Disinfectant solution detergency of the present invention reaches
95%；Toxicologic study shows, the acute oral toxicity LD50 value ＞ 5000mg/kg of 5 times of concentration application, reaches actual nontoxic
Level, to no skin irritation.Disinfectant solution of the present invention is non-volatile, good stability, is valid up to 2 years.Do not fire the most quick-fried, transport storage
Deposit safe ready.Actually used low cost.Do not result in secondary pollution.
Accompanying drawing explanation
Fig. 1 complex quaternary ammonium salts of the present invention disinfectant solution prepare industrial flow chart.
Detailed description of the invention
Below in conjunction with specific embodiment further describe the present invention, advantages of the present invention and feature will be with describe and
Apparent.It should be understood that described embodiment is only exemplary, the scope of the present invention is not constituted any restriction.This area
Skilled artisans appreciated that, lower without departing from the spirit and scope of the present invention can to the details of technical solution of the present invention and
Form is modified or replaces, but these amendments or replacement each fall within protection scope of the present invention.
Blender used in the present invention is the blender of Nanjing gold hard iron pharmaceutical equipment G-300；
Reactor used in the present invention is the reactor of the 500Kg that Nanjing Jin Ju pharmaceutical equipment factory produces.
The preparation of embodiment 1 complex quaternary ammonium salts disinfectant solution
(1) first by 25kg hexamethylenetetramine, 8kg benzalkonium bromide, 1kg benzalkonium chloride, 0.5kg polyhexamethylene guanidine,
0.3kg Tween 80,0.5kg octadecyl dimethyl benzyl part chloride join at 30 DEG C in 64.2kg sterilized water, pressure
Mix and blend 2 hours under conditions of 100Kpa, blender rotating speed is 110 revs/min, joins in reactor after stirring；
(2) again 0.5kg isopropanol is joined in reactor, at 32 DEG C, stirs 6 hours under conditions of pressure 101Kpa,
Blender rotating speed is 510 revs/min；
(3) after the material in reactor being stood aging 12 hours, detecting active constituent content, filtration, fill i.e. obtain.
After testing, active constituent content is (unit is mass percent): hexamethylenetetramine 25%, benzalkonium bromide 8%,
Benzalkonium chloride 1%, polyhexamethylene guanidine 0.5%, octadecyl dimethyl benzyl part chloride 0.5%.As defective, do not reach
Active constituent content, discarded.After detection active constituent content is qualified, fill is finished product disinfectant solution.After finished product is qualified after testing
Warehouse-in, dispatches from the factory.
The preparation of embodiment 2 complex quaternary ammonium salts disinfectant solution
(1) first by 29kg hexamethylenetetramine, 9kg benzalkonium bromide, 1.5kg benzalkonium chloride, 1.25kg polyhexamethylene guanidine,
1.15kg Tween 80,3.25kg octadecyl dimethyl benzyl part chloride join at 25 DEG C in 54.85kg sterilized water, pressure
Mix and blend 1.5 hours under conditions of 100Kpa, blender rotating speed is 105 revs/min, joins in reactor after stirring；
(2) again 1.25kg isopropanol is joined in reactor, at 25 DEG C, stirs 5 hours under conditions of pressure 101Kpa,
Blender rotating speed is 505 revs/min；
(3) material in reactor is stood after aging 11 hours, detect active constituent content, fill bucket and get final product.
Through detection, active constituent content is (unit is mass percent): hexamethylenetetramine 29%, benzalkonium bromide
9%, benzalkonium chloride 1.25%, polyhexamethylene guanidine 1.25%, octadecyl dimethyl benzyl part chloride 3.25%.
The preparation of embodiment 3 complex quaternary ammonium salts disinfectant solution
(1) first by 33kg hexamethylenetetramine, 10kg benzalkonium bromide, 2kg benzalkonium chloride, 2kg polyhexamethylene guanidine, 2kg
Tween 80,6kg octadecyl dimethyl benzyl part chloride join at 18 DEG C in 43kg sterilized water, the condition of pressure 100Kpa
Lower mix and blend 1 hour, blender rotating speed is 100 revs/min, joins in reactor after stirring；
(2) again 2kg isopropanol is joined in reactor, at 20 DEG C, stir 4 hours under conditions of pressure 100KPa, stir
The machine rotating speed of mixing is 500 revs/min；
(3), after the material in reactor being stood aging 10 hours, detect active constituent content, pour into pail pack and get final product.
Through detection, active constituent content is (unit is mass percent): hexamethylenetetramine 33%, benzalkonium bromide
10%, benzalkonium chloride 2%, polyhexamethylene guanidine 2%, octadecyl dimethyl benzyl part chloride 6%.
The safety experiment of experimental example 1 disinfectant solution of the present invention
Detect after disinfectant solution prepared by embodiment of the present invention 1-3 is diluted 100 times, toxicity on inhalation, the skin thorn to it
Swash property, eye irritation, drug resistance, anti-interference, corrosion disease, stability, Disinfection Effect, residual toxicity, biological degradability etc. each
Performance parameter carry out detecting and with the properties by conventional disinfectant formaldehyde, glutaraldehyde, peracetic acid, lactic acid and ozone
Parameter contrasts.
Testing result is shown in Table 1.Each item data from table 1, disinfectant solution of the present invention is safe to the human body, nontoxic, harmless,
Non-stimulated, corrosion-free to equipment；Environmentally safe, degradable. disinfectant solution of the present invention include toxicity on inhalation, skin irritation
Property, eye irritation, drug resistance, anti-interference, corrosion disease, stability, Disinfection Effect, residual toxicity, biological degradability etc. are every
Performance parameter to be substantially better than the various performance parameters of disinfectant formaldehyde, glutaraldehyde, peracetic acid, lactic acid and the ozone of routine.
Table 1 data of safety
Experimental example 2 disinfectant solution of the present invention and the superiority comparative experiments of conventional disinfectant solution
After disinfectant solution embodiment of the present invention 1-3 prepared releases 50 times, detect respectively its Disinfection Effect, the antibacterial time,
The various performance parameters such as zest, drug resistance, toxicity and storage the parameters with ethanol, quaternary ammonium salt and hibitane are carried out
Contrast.
From the data of table 2, disinfectant solution of the present invention Disinfection Effect, the antibacterial time, zest, drug resistance, toxicity and
Ethanol to be significantly better than, quaternary ammonium salt and the various performance parameters of hibitane in the various performance parameters such as storage.
Table 2 superiority data
The henchnmrk test of experimental example 3 disinfectant solution of the present invention
Disinfectant solution prepared by embodiment of the present invention 1-3 detect after being diluted according to the concentration of table 3 its kill escherichia coli,
Staphylococcus aureus, Candida albicans, bacillus subtilis black variety gemma, aspergillus niger, Pseudomonas aeruginosa, clostridium sporogenes and
Bacillus subtilis kill logarithm value.
From experimental result, disinfectant solution of the present invention is for escherichia coli, staphylococcus aureus, Candida albicans, withered
Grass bacillus var. niger spores, aspergillus niger, Pseudomonas aeruginosa, clostridium sporogenes and bacillus subtilis kill logarithm value ＞ 5
(2min)；Illustrating that disinfectant solution of the present invention has good bactericidal effect, sterilization cleaning can synchronously complete.
Table 3 performance evaluation data
Claims (10)
1. a complex quaternary ammonium salts disinfectant solution, it is characterised in that include following component: hexamethylenetetramine, benzalkonium bromide, benzene
Prick oronain, polyhexamethylene guanidine, Tween 80, octadecyl dimethyl benzyl part chloride, isopropanol and sterilized water.
2. according to the complex quaternary ammonium salts disinfectant solution described in claim 1, it is characterised in that the weight portion of each component is: six methylenes
Urotropine 25～33 parts, benzalkonium bromide 8～10 parts, benzalkonium chloride 1～2 parts, polyhexamethylene guanidine 0.5～2 parts, Tween 80 0.3
～2 parts, octadecyl dimethyl benzyl part chloride 0.5～6 parts, isopropanol 0.5～2 parts, sterilized water 43～64.2 parts.
3. according to the complex quaternary ammonium salts disinfectant solution described in claim 2, it is characterised in that the weight portion of each component is: six methylenes
Urotropine 29 parts, benzalkonium bromide 9 parts, benzalkonium chloride 1.25 parts, polyhexamethylene guanidine 1.25 parts, octadecyl dimethyl benzyl part
Chloride 3.25 parts, isopropanol 1.25 parts, sterilized water 54.85 parts.
4. prepare the method for complex quaternary ammonium salts disinfectant solution described in claim 1-3 any one for one kind, it is characterised in that include with
Lower step:
(1) each component is weighed according to described weight proportion；
(2) first by hexamethylenetetramine, benzalkonium bromide, benzalkonium chloride, polyhexamethylene guanidine, octadecyl dimethyl benzyl part chlorine
Compound, Tween 80 and sterilized water mix and blend；Mixture after stirring is joined in reactor；
(3) propanol is joined in reactor it is sufficiently stirred for mixture, stands, filters, detects, fill and get final product.
The most in accordance with the method for claim 4, it is characterised in that the stirring described in step (1) or (2) be at room temperature, often
Mix and blend is carried out under the conditions of pressure；Described normal temperature condition is 18～32 DEG C, the pressure of described condition of normal pressure be 100KPa～
101KPa。
The most in accordance with the method for claim 4, it is characterised in that the mixing time described in step (1) is 1～2 hour, stirring
Machine rotating speed is 100～110 revs/min.
The most in accordance with the method for claim 4, it is characterised in that the mixing time described in step (2) is 4～6 hours, stirs
The machine rotating speed of mixing is 500～510 revs/min.
The most in accordance with the method for claim 4, it is characterised in that the time of repose described in step (3) is 10～12 hours.
9. the application in preparation disinfectant of the complex quaternary ammonium salts disinfectant solution described in claim 1-3 any one.
10. complex quaternary ammonium salts disinfectant solution application in preparing topical cleansers described in claim 1-3 any one.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106719772A (en) * | 2016-11-22 | 2017-05-31 | 俞潮军 | A kind of environment-friendly high-efficiency compound disinfectant |
| CN106857659A (en) * | 2017-04-01 | 2017-06-20 | 江西凝盛生物科技有限公司 | A kind of thing table thimerosal of asepsis environment-protecting and preparation method thereof |
| CN109380281A (en) * | 2018-09-30 | 2019-02-26 | 刘家鹤 | A kind of endoscopy disinfection agent with anti-fog function |
| CN113016799A (en) * | 2021-02-24 | 2021-06-25 | 杭州西子卫生消毒药械有限公司 | Low-temperature-resistant disinfectant and preparation method thereof |
| CN113383775A (en) * | 2021-07-19 | 2021-09-14 | 广东环凯生物技术有限公司 | Compound quaternary ammonium salt low-temperature disinfectant and preparation method thereof |
| CN114129552A (en) * | 2021-11-29 | 2022-03-04 | 青岛康露科技有限公司 | Compound disinfectant and production method and application thereof |
| CN114503977A (en) * | 2022-01-26 | 2022-05-17 | 民政部一零一研究所 | Remains preservative with detumescence, fading and odor removing functions and preparation method thereof |
| CN114532352A (en) * | 2022-01-26 | 2022-05-27 | 苏州百灵威超精细材料有限公司 | Compound quaternary ammonium salt long-acting disinfectant and preparation method and application thereof |
| CN114931138A (en) * | 2021-10-13 | 2022-08-23 | 深圳市华宝生物材料科技有限公司 | Sterilization disinfectant and preparation method thereof |
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106719772A (en) * | 2016-11-22 | 2017-05-31 | 俞潮军 | A kind of environment-friendly high-efficiency compound disinfectant |
| CN106857659A (en) * | 2017-04-01 | 2017-06-20 | 江西凝盛生物科技有限公司 | A kind of thing table thimerosal of asepsis environment-protecting and preparation method thereof |
| CN109380281A (en) * | 2018-09-30 | 2019-02-26 | 刘家鹤 | A kind of endoscopy disinfection agent with anti-fog function |
| CN113016799A (en) * | 2021-02-24 | 2021-06-25 | 杭州西子卫生消毒药械有限公司 | Low-temperature-resistant disinfectant and preparation method thereof |
| CN113016799B (en) * | 2021-02-24 | 2021-10-26 | 杭州西子卫生消毒药械有限公司 | Low-temperature-resistant disinfectant and preparation method thereof |
| CN113383775A (en) * | 2021-07-19 | 2021-09-14 | 广东环凯生物技术有限公司 | Compound quaternary ammonium salt low-temperature disinfectant and preparation method thereof |
| CN114931138A (en) * | 2021-10-13 | 2022-08-23 | 深圳市华宝生物材料科技有限公司 | Sterilization disinfectant and preparation method thereof |
| CN114931138B (en) * | 2021-10-13 | 2023-10-20 | 拓腾华宝(苏州)生物技术有限公司 | Sterilization disinfectant and preparation method thereof |
| CN114129552A (en) * | 2021-11-29 | 2022-03-04 | 青岛康露科技有限公司 | Compound disinfectant and production method and application thereof |
| CN114129552B (en) * | 2021-11-29 | 2024-01-02 | 青岛康露科技有限公司 | Compound disinfectant and production method and application thereof |
| CN114503977A (en) * | 2022-01-26 | 2022-05-17 | 民政部一零一研究所 | Remains preservative with detumescence, fading and odor removing functions and preparation method thereof |
| CN114532352A (en) * | 2022-01-26 | 2022-05-27 | 苏州百灵威超精细材料有限公司 | Compound quaternary ammonium salt long-acting disinfectant and preparation method and application thereof |
| CN114503977B (en) * | 2022-01-26 | 2023-03-03 | 民政部一零一研究所 | Remains preservative with detumescence, fading and odor removing functions and preparation method thereof |
| CN114532352B (en) * | 2022-01-26 | 2023-11-21 | 苏州百灵威超精细材料有限公司 | Composite quaternary ammonium salt long-acting disinfectant and preparation method and application thereof |
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Addressee: General Hospital, Chinese People's Armed Police Troops Document name: the First Notification of an Office Action |
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Application publication date: 20161026 |