CN101375685B - Disinfectant liquid and method for producing the same - Google Patents
Disinfectant liquid and method for producing the same Download PDFInfo
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- CN101375685B CN101375685B CN2008101967878A CN200810196787A CN101375685B CN 101375685 B CN101375685 B CN 101375685B CN 2008101967878 A CN2008101967878 A CN 2008101967878A CN 200810196787 A CN200810196787 A CN 200810196787A CN 101375685 B CN101375685 B CN 101375685B
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- 238000004519 manufacturing process Methods 0.000 title claims description 17
- 239000000645 desinfectant Substances 0.000 title abstract description 12
- 239000007788 liquid Substances 0.000 title description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 21
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 claims abstract description 11
- 235000011187 glycerol Nutrition 0.000 claims abstract description 11
- 238000003756 stirring Methods 0.000 claims abstract description 10
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 8
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract description 8
- 230000032683 aging Effects 0.000 claims abstract description 6
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 claims description 14
- 229940033663 thimerosal Drugs 0.000 claims description 14
- 229920002413 Polyhexanide Polymers 0.000 claims description 10
- XJENSLNYTFOSKA-UHFFFAOYSA-M [Cl-].C(CCCCCCCCCCCCCCC)[N+](CC1=CC=CC=C1)(C)C.[Cl-].[NH4+] Chemical compound [Cl-].C(CCCCCCCCCCCCCCC)[N+](CC1=CC=CC=C1)(C)C.[Cl-].[NH4+] XJENSLNYTFOSKA-UHFFFAOYSA-M 0.000 claims description 10
- 239000000470 constituent Substances 0.000 claims description 10
- DLFDEDJIVYYWTB-UHFFFAOYSA-N dodecyl(dimethyl)azanium;bromide Chemical compound Br.CCCCCCCCCCCCN(C)C DLFDEDJIVYYWTB-UHFFFAOYSA-N 0.000 claims description 10
- 238000012545 processing Methods 0.000 claims description 5
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 19
- 230000001954 sterilising effect Effects 0.000 abstract description 13
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 10
- 230000008901 benefit Effects 0.000 abstract description 6
- 230000007797 corrosion Effects 0.000 abstract description 4
- 238000005260 corrosion Methods 0.000 abstract description 4
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 abstract description 4
- 238000000034 method Methods 0.000 abstract description 4
- -1 hexadecyl benzyl Chemical group 0.000 abstract description 3
- 235000013305 food Nutrition 0.000 abstract description 2
- 230000000638 stimulation Effects 0.000 abstract description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 235000019270 ammonium chloride Nutrition 0.000 abstract 1
- 238000002485 combustion reaction Methods 0.000 abstract 1
- 229960004670 didecyldimethylammonium chloride Drugs 0.000 abstract 1
- 238000004880 explosion Methods 0.000 abstract 1
- 239000008213 purified water Substances 0.000 abstract 1
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 description 21
- 239000000203 mixture Substances 0.000 description 16
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 14
- 239000004155 Chlorine dioxide Substances 0.000 description 10
- 235000019398 chlorine dioxide Nutrition 0.000 description 10
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 241000235342 Saccharomycetes Species 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229960002233 benzalkonium bromide Drugs 0.000 description 3
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 description 3
- 229910052801 chlorine Inorganic materials 0.000 description 3
- 239000000460 chlorine Substances 0.000 description 3
- 239000003651 drinking water Substances 0.000 description 3
- 235000020188 drinking water Nutrition 0.000 description 3
- 208000007475 hemolytic anemia Diseases 0.000 description 3
- 235000010299 hexamethylene tetramine Nutrition 0.000 description 3
- 229960004011 methenamine Drugs 0.000 description 3
- 231100000252 nontoxic Toxicity 0.000 description 3
- 230000003000 nontoxic effect Effects 0.000 description 3
- 150000002978 peroxides Chemical class 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- 206010009944 Colon cancer Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 2
- CVXHBROPWMVEQO-UHFFFAOYSA-N Peroxyoctanoic acid Chemical compound CCCCCCCC(=O)OO CVXHBROPWMVEQO-UHFFFAOYSA-N 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 231100000460 acute oral toxicity Toxicity 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 208000029742 colonic neoplasm Diseases 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 231100000053 low toxicity Toxicity 0.000 description 2
- 208000005135 methemoglobinemia Diseases 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- 241000370738 Chlorion Species 0.000 description 1
- 241000193403 Clostridium Species 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000726221 Gemma Species 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 108010061951 Methemoglobin Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000031320 Teratogenesis Diseases 0.000 description 1
- IKHGUXGNUITLKF-XPULMUKRSA-N acetaldehyde Chemical compound [14CH]([14CH3])=O IKHGUXGNUITLKF-XPULMUKRSA-N 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 201000001531 bladder carcinoma Diseases 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 239000013064 chemical raw material Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- RCTYPNKXASFOBE-UHFFFAOYSA-M chloromercury Chemical compound [Hg]Cl RCTYPNKXASFOBE-UHFFFAOYSA-M 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
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- 230000003670 easy-to-clean Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 231100000225 lethality Toxicity 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 238000006385 ozonation reaction Methods 0.000 description 1
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- 102000004169 proteins and genes Human genes 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a disinfection solution and a producing method thereof. Specifically, the disinfection solution can be used as a specialized disinfectant which is used in food, medical treatment, pharmacy, and the like, and a corresponding antibacterial product can be developed for the use in daily life. The producing method comprises the following steps: adding propanetriol in formamine, further adding Polyhexamethylenebiguanidine Hydrochloride, adding in a reactor after stirring, adding EDDAB, Didecyl dimethyl ammonium chloride, and hexadecyl benzyl dimethly ammonium chloride in the reactor in sequence, further adding isopropanol, tween 80 and purified water, stirring, standing for ageing, checking, and pouring into a package barrel to obtain a finished good. The invention has the advantages of no harm to the human body, innocuity, degradability, convenient operation, convenient use because water can be used to dilute, convenient storage and transportation because of no combustion and explosion, no stimulation, no corrosion, and low cost because no second pollution is caused after the sterilizing.
Description
Technical field
The present invention relates to a kind of thimerosal and production method thereof, specifically its professional disinfectant of not only can be used as relevant industries such as food, medical treatment, pharmacy uses, and also can develop the daily family life that corresponding anti-antibacterial product is applied to people.
Background technology
Present sterile products is many to be main component with single chemical raw material, though can guarantee Disinfection Effect, may cause secondary to poison to human body or environment after the sterilization.
For example the most frequently used disinfectant mostly is chlorine, bromine, iodine or the compound that can discharge halogen accordingly.This type of disinfectant consumption maximum be chlorine because raw material are easy to get, preparation easily, low price, bactericidal action is reliable, therefore is used widely.But this type of disinfectant has penetrating odor, skin there is stimulation, be corrosive, poor stability, the bactericidal action duration is short, particularly points out according to the epidemiology survey data of Keuny CrumpaScience Research System in recent years: cholorination drinking-water easily brings out the carcinoma of the rectum, colon cancer and carcinoma of urinary bladder.Investigation according to another Tj erese Young is thought: the lethality of colon cancer is higher in the crowd of drink cholorination water, and to a certain extent its may to cause some saccharomycete and lactic acid bacteria to form the drug-fast fact often out in the cold.The use of iodide is very popular in the seventies, because its sediment causes the extensive fracture of equipment and progressively is eliminated, finds that in addition the part operation personnel are to this type of material extrasensitivity (allergy) at present.
Ozone and chlorine dioxide are the rapid effective disinfectant of sterilization, and the disinfection efficiency of ozone is higher one than chlorine, extensively kill bacteria, algae, virus and spore, it is a kind of wide-spectrum bactericide, simultaneously organic matter in the oxidize water quickly reduces BOD, COD effectively.Use morely in Europe, but price is more expensive, and equipment investment height, corrosivity cause that greatly, easily container or pipeline and coating corrosion decompose, and catabolite enters in the water, can cause secondary pollution.Ozonization without aftereffect in addition, the disinfective action duration is short.Chlorine dioxide is the new disinfectant of development in recent years, it is a kind of wide-spectrum bactericide, but many animal test results have shown carcinogenic, the teratogenesis shape of long-term use meeting, for example chlorine dioxide is taken in the small white mouse stomach, chlorine dioxide is absorbed with chlorion and chlorine dioxide form, chlorine dioxide can oxygenated haemoglobin, makes it to be converted into the ferrihemoglobin of non-pigment function, makes animal that methemoglobinemia take place.The record of hemolytic anemia occurs after also having oral chlorine dioxide in addition, and find to produce the needed chlorine dioxide dosages of hemolytic anemia and want much less than producing the required chlorine dioxide dosages of methemoglobinemia.Experimental results show that when containing chlorine dioxide 100mg/l in the drinking-water, can be observed tangible hemolytic anemia phenomenon in the small white mouse body, and contain chlorine dioxide 50mg/l in the drinking-water, even when being lower than 10mg/l, though tangible clinical symptoms do not occur, glutathione obviously reduces in the body.
Peroxide also is that a class is used disinfection composition more widely, mainly contain hydrogen peroxide (hydrogen peroxide), Peracetic acid, Peroxycaprylic acid etc., wherein the most familiar is exactly hydrogen peroxide, this close special education in 1864 is awarded and has just been found that hydrogen peroxide has bactericidal action, and sterilizing ability is near mercury chloride.Hydrogen peroxide can be killed the most obstinate anthrax-bacilus spore when concentration 100mg/l, and clostridium is also had good killing action, and its highly-water-soluble makes it be easy to clean.But its limited advantage has unfortunately been offset by some serious defectives: its good bactericidal property of active concentration that only reaches qualification just can be guaranteed.The influence of temperature, pH value and heavy metal can both make it lose activity, and it can produce incomplete chemical reaction with most of materials, as ethanol, acetone, acetaldehyde, metal ion, sodium hydroxide etc.In addition, peroxide is attacked skin and is arrived subcutaneus adipose tissue and causes the gangrenosis that is difficult to cure, and it caused tumour in some zooperies." highway transportations of dangerous goods " according to Germany reach " railway transportations of dangerous goods " decree, and delivery container forbids carrying this type of material above 25KG.So hydrogen peroxide as the disadvantage of disinfectant be poor stability, the sterilization duration is short, sterilization speed is slow, surface tension is big, price is high.
It is fast that the ultraviolet radiation sterilization has speed, advantage such as easy and simple to handle, but the use cost height is arranged also, deficiencies such as the duration is short, and disinfection by ultraviolet light is applicable to air sterillization more, generally do not recommend to use in water sterilization, because ultraviolet ray is poor to the penetration power of water, decay comparatively fast can influence bactericidal action in water.In addition, ultraviolet ray has the effect of stimulating growth to certain micro-organisms cell such as Escherichia coli.
Neutral quarternary ammonium salt compound belongs to the category of low toxicity, and it is used for the mucous membrane sterilization for many years, and according to " Switzerland's noxious material method ", its oral acute toxicity intensity is about 4000mg/kg, so it is a low toxicity.The gathering of its active tension cell membrane has better action.
Aldehydes is a kind of widely applicable disinfectant, be used to the sterilization of a lot of aspects, theory according to the Heicken professor, its broad bactericidal range comprises bacterium, mould, saccharomycete, virus and spore, fungicidal effectiveness can be influenced by protein or similar substance hardly, the solution-stabilized phase is long, use proof it can reach satisfied effect as disinfectant with the solution of 1-2% through long-term, but its tangible toxicity and excitant has increased the worry of people to safety again.
Because existing chemical disinfection composition all has apparent in view pluses and minuses, for these reasons, have only different chemical compositions is carried out compositely just can reaching more satisfactory balance between bactericidal properties and safety.
Inquiry according to related data, only find to have the composite sterile products of similar chemical substance, mixture as mixture, Peracetic acid (10%) and the hydrogen peroxide (10%) of Peracetic acid (10%) and Peroxycaprylic acid (10%), because this type of prescription is still using same class chemical substance to mix, so still do not break away from the applied defect of peroxide.
Summary of the invention
The objective of the invention is to overcome above-mentioned weak point, thereby provide a kind of to human body safety, nontoxic, harmless, degradable, easy to use, directly dilute with water can use, and does not fire not quick-fried transportation and stores safe ready, non-stimulated, do not have corrosion, actual use cost is low, can not cause the thimerosal and the production method thereof of the secondary pollution after the sterilization.
According to technical scheme provided by the invention, a kind of thimerosal, its component proportioning is counted by weight:
Get hexa: 20-40 part, dodecyl dimethyl ammonium bromide: 3-7 part, DDAC: 2-6 part, hexadecyldimethyl benzyl ammonium ammonium chloride: 0.5-2 part, polyhexamethylene guanide: 0.5-2 part, isopropyl alcohol: 0.5-2 part, glycerine: 0.5-2 part, Tween 80: 0.5-2 part, pure water: 37-72.5 part;
Earlier glycerine is joined in the hexa, adding polyhexamethylene guanide again joins in the reactor through stirring, adding dodecyl dimethyl ammonium bromide, DDAC and hexadecyldimethyl benzyl ammonium ammonium chloride joins in the reactor successively, add isopropyl alcohol, Tween 80 and pure water again, aging through stirring, leaving standstill again, detecting and pouring into pail pack is finished product.
The production method of a kind of thimerosal of the present invention, adopt following processing step: its component proportioning is counted by weight:
1, earlier glycerine 0.5-2 part is joined in hexa 20-40 part, add polyhexamethylene guanide 0.5-2 part again, mix stirring 1-2 hour down at normal temperature (20-30 ℃) normal pressure (1 atmospheric pressure), join in the reactor 100-110 rev/min of agitator rotating speed;
2, join dodecyl dimethyl ammonium bromide 3-7 part, DDAC 2-6 part and hexadecyldimethyl benzyl ammonium ammonium chloride 0.5-2 part in the reactor successively;
3, again isopropyl alcohol 0.5-2 part, Tween 80 0.5-2 part and pure water 37-72.5 part are joined in the reactor, stirred 4-6 hour down, make the mixture dissolving evenly, 500-510 rev/min of agitator rotating speed at normal temperature (20-30 ℃) normal pressure (1 atmospheric pressure);
4, after said mixture fully stirs, leave standstill and wear out after 47-49 hour, after the detection active constituent content was qualified, pouring into pail pack was the finished product thimerosal.
Compared with the prior art the present invention has the following advantages:
The present invention is to human body safety, and is nontoxic, harmless, degradable.Easy to use, directly dilute with water can use.Do not fire not quick-friedly, safe ready is stored in transportation.Non-stimulated, there is not corrosion.Actual use cost is low, can not cause the secondary pollution after the sterilization.According to result of study and feedback on probation, this product can effectively reduce the disinfection cost of manufacturing enterprise, reaches the sterilization requirement of manufacturing enterprise, can produce good economic benefit and environmental benefit.
The present invention's uniqueness of filling a prescription, effect is remarkable, does not see both at home and abroad to have novelty by bibliographical information, has popularizing application prospect preferably.
Description of drawings
Fig. 1 is a process flow diagram of the present invention.
Embodiment
Embodiment during following the present invention incites somebody to action in conjunction with the accompanying drawings is further described:
Embodiment one:
The production method of a kind of thimerosal of the present invention, adopt following processing step:
1, with 2 kilograms of glycerine (trade name: glycerine, purity: 99%) join 40 kilograms of hexa (trade names: methenamine, purity: 99%), add 2 kilograms of polyhexamethylene guanide (purity: 99%) again, under the condition of 30 ℃ of normal temperature, normal pressure (1 atmospheric pressure), mix and stirred 2 hours, agitator (model: B30 type, the production of the South Sea, Guangdong De Feng heating equipment factory) rotating speed is 110 rev/mins, join in the reactor (capacity: 500KG, Wuxi City small stream river medical equipment factory produces).
2, with 7 kilograms of dodecyl dimethyl ammonium bromide (trade names: benzalkonium bromide, 99%), 6 kilograms of DDAC (purity: 99%) and 2 kilograms of hexadecyldimethyl benzyl ammonium ammonium chloride (purity: 99%) join successively in the reactor (capacity: 500KG, Wuxi City small stream river medical equipment factory produces) purity:.
99%), 2 kilograms of poly-sorb fat 80 (trade names: Tween 80 3, again with 2 kilograms of isopropyl alcohols (purity:, purity: 99%) and 37 kilograms of pure water join reactor (capacity: 500KG, Wuxi City small stream river medical equipment factory produces) in, under the condition under 30 ℃ of normal temperature, the normal pressure (1 atmospheric pressure), mix and stirred 6 hours, make the mixture dissolving evenly, 510 rev/mins of agitator (model: B30 type, the production of the South Sea, Guangdong De Feng heating equipment factory) rotating speeds.
4, after said mixture fully stirs, leave standstill aging after 49 hours, detect active constituent content, active constituent content should be: hexa 40%, polyhexamethylene guanide 2%, dodecyl dimethyl ammonium bromide 7%, DDAC 6%, hexadecyldimethyl benzyl ammonium ammonium chloride 2% is as defective, do not reach active constituent content, promptly discarded.After the detection active constituent content was qualified, pouring into pail pack was the finished product thimerosal.Longitude detects the finished product warehousing after passing, dispatches from the factory.
The present invention has overcome the deficiency of single component disinfectant, by synergy, has efficient, safe characteristics.The 1:1000 dilution of product of the present invention can effectively be killed pathogenic entero becteria, pyococcus, pathogenic saccharomycete in 5 minutes after testing; Effective inactivated avian influenza virus; The 1:100 dilution can be killed bacillus subtilis black variety gemma in 10 minutes.Toxicologic study shows that 5 times of concentration are used the acute oral toxicity LD of liquid
50Value〉5000mg/kg, reach actual nontoxic level, to the skin nonirritant.Non-volatile, good stability was valid up to 2 years.
Embodiment two:
The production method of a kind of thimerosal of the present invention, adopt following processing step:
1, with 1 kilogram of glycerine (trade name: glycerine, purity: 99%) join 30 kilograms of hexa (trade names: methenamine, purity: 99%), add 1 kilogram of polyhexamethylene guanide (purity: 99%) again, under the condition of 25 ℃ of normal temperature, normal pressure (1 atmospheric pressure), stirred 1.5 hours, agitator (model: B30 type, the production of the South Sea, Guangdong De Feng heating equipment factory) rotating speed is 105 rev/mins, join in the reactor (capacity: 500KG, Wuxi City small stream river medical equipment factory produces).
2, with 6 kilograms of dodecyl dimethyl ammonium bromide (trade names: benzalkonium bromide, 99%), 4 kilograms of DDAC (purity: 99%) and 1 kilogram of hexadecyldimethyl benzyl ammonium ammonium chloride (purity: 99%) join successively in the reactor (capacity: 500KG, Wuxi City small stream river medical equipment factory produces) purity:.
99%), 1 kilogram of poly-sorb fat 80 (trade name: Tween 80 3, again with 1 kilogram of isopropyl alcohol (purity:, purity: 99%) and 55 kilograms of pure water join reactor (capacity: 500KG, Wuxi City small stream river medical equipment factory produces) in, under the condition of 25 ℃ of normal temperature, normal pressure (1 atmospheric pressure), stirred 5 hours, make the mixture dissolving evenly, 505 rev/mins of agitator (model: B30 type, the production of the South Sea, Guangdong De Feng heating equipment factory) rotating speeds.
4, after said mixture fully stirs, leave standstill aging after 48 hours, detect active constituent content: hexa 30%, polyhexamethylene guanide 1%, dodecyl dimethyl ammonium bromide 6%, DDAC 4%, hexadecyldimethyl benzyl ammonium ammonium chloride 1%, after active constituent content was qualified, pouring into pail pack was the finished product thimerosal.
Embodiment three:
The production method of a kind of thimerosal of the present invention, adopt following processing step:
1, with 0.5 kilogram of glycerine (trade name: glycerine, purity: 99%) join 20 kilograms of hexa (trade names: methenamine, purity: 99%), add 0.5 kilogram of polyhexamethylene guanide (purity: 99%) again, under the condition of 20 ℃ of normal temperature, normal pressure (1 atmospheric pressure), stirred 1 hour, agitator (model: B30 type, the production of the South Sea, Guangdong De Feng heating equipment factory) rotating speed is 100 rev/mins, join in the reactor (capacity: 500KG, Wuxi City small stream river medical equipment factory produces).
2, with 3 kilograms of dodecyl dimethyl ammonium bromide (trade names: benzalkonium bromide, 99%), 2 kilograms of DDAC (purity: 99%) and 0.5 kilogram of hexadecyldimethyl benzyl ammonium ammonium chloride (purity: 99%) join successively in the reactor (capacity: 500KG, Wuxi City small stream river medical equipment factory produces) purity:.
99%), 0.5 kilogram of poly-sorb fat 80 (trade name: Tween 80 3, again with 0.5 kilogram of isopropyl alcohol (purity:, purity: 99%) and 72.5 kilograms of pure water join reactor (capacity: 500KG, Wuxi City small stream river medical equipment factory produces) in, under the condition of 20 ℃ of normal temperature, normal pressure (1 atmospheric pressure), stirred 4 hours, make the mixture dissolving evenly, 500 rev/mins of agitator (model: B30 type, the production of the South Sea, Guangdong De Feng heating equipment factory) rotating speeds.
4, after said mixture fully stirs, leave standstill aging after 47 hours, detect active constituent content: hexa 20%, polyhexamethylene guanide 0.5%, dodecyl dimethyl ammonium bromide 3%, DDAC 2%, hexadecyldimethyl benzyl ammonium ammonium chloride 0.5%, after active constituent content was qualified, pouring into pail pack was the finished product thimerosal.
Table one: be effective component content of the present invention
Table two: be effective component content of the present invention
Claims (1)
1. the production method of a thimerosal, it is characterized in that: adopt following processing step: its component proportioning is counted by weight:
(1), glycerine 0.5-2 part is joined in hexa 20-40 part, add polyhexamethylene guanide 0.5-2 part again, mix under normal temperature, normal pressure and stirred 1-2 hour, 100-110 rev/min of agitator rotating speed joins in the reactor;
(2), join dodecyl dimethyl ammonium bromide 3-7 part, DDAC 2-6 part and hexadecyldimethyl benzyl ammonium ammonium chloride 0.5-2 part in the reactor successively;
(3), isopropyl alcohol 0.5-2 part, Tween 80 0.5-2 part and pure water 37-72.5 part are joined in the reactor, under normal temperature, normal pressure, stirred 4-6 hour 500-510 rev/min of agitator rotating speed;
(4), leave standstill again after stirring aging after 47-49 hour, detect active constituent content qualified after, pouring into pail pack is the finished product thimerosal.
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| CN102165953A (en) * | 2011-03-01 | 2011-08-31 | 无锡乔优科技有限公司 | Hand disinfectant and production method thereof |
| CN102113973B (en) * | 2011-03-01 | 2012-06-27 | 无锡乔优科技有限公司 | Oral cavity disinfecting liquor and production method thereof |
| CN102150669B (en) * | 2011-03-01 | 2013-06-12 | 无锡乔优科技有限公司 | Disinfectant and producing method thereof |
| CN103893796A (en) * | 2012-12-25 | 2014-07-02 | 南京恒青楼宇设备有限公司青岛分公司 | Solid air freshener for vehicles |
| CN105284860A (en) * | 2014-06-16 | 2016-02-03 | 盐城市聚科化工有限公司 | Multiple-effect antibacterial agent composition for wet tissue and production method thereof |
| CN106035361A (en) * | 2016-05-23 | 2016-10-26 | 中国人民武装警察部队总医院 | Compound quaternary ammonium salt disinfection solution, and preparation method and application thereof |
| CN106857659A (en) * | 2017-04-01 | 2017-06-20 | 江西凝盛生物科技有限公司 | A kind of thing table thimerosal of asepsis environment-protecting and preparation method thereof |
| CN112251025A (en) * | 2020-10-11 | 2021-01-22 | 深圳市捷安纳米复合材料有限公司 | Sterilizing and virus-killing protective film and preparation method thereof |
| CN113875613B (en) * | 2021-11-16 | 2023-07-25 | 来宾市畜牧水产养殖服务中心 | Beef cattle biological padding bed and using method thereof |
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| CN1647643A (en) * | 2004-12-29 | 2005-08-03 | 广州泰成消毒洗涤用品有限公司 | Disinfectant |
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