CN1328957C - Multielement syneryistic multifunction broad spectrum disinfectant and its application - Google Patents
Multielement syneryistic multifunction broad spectrum disinfectant and its application Download PDFInfo
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- CN1328957C CN1328957C CNB2003101091067A CN200310109106A CN1328957C CN 1328957 C CN1328957 C CN 1328957C CN B2003101091067 A CNB2003101091067 A CN B2003101091067A CN 200310109106 A CN200310109106 A CN 200310109106A CN 1328957 C CN1328957 C CN 1328957C
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Abstract
The present invention relates to a multi-element synergistic multifunctional broad-spectrum disinfectant and an application thereof. The matrix of the disinfectant comprises 0.05 to 4.5 wt% of antimicrobial agents, 0.005 to 0.5 wt% of quaternary amine salt compounds, 0.025 to 3 wt% of chlorophenol compounds and 92 to 99.9 wt% of alcohol. The disinfectant is used for preparing disinfected soaps, cosmetics with functions of sterilization and anticorrosion, sterilized wet towels, aqueous agents, spraying agents, emulsion, cream, gel disinfectants, etc. With the disinfectant, a method for preventing and killing bacteria on skins and the surfaces of other objects is provided. Compared with the prior art, the present invention has the advantages of compatibility, concertedness and synergistic performance among the selected components, and can be widely used in hospitals, medical and public health departments, various places about public health, families, etc.
Description
Technical field
Polyploid Synergistic multifunctional broad-spectrum disinfectant belongs to the sterile products in biological medicine sterilization field, mainly is applicable to the sterilization of dwelling house, building, hospital, hotel, school, child-care center of nursery schools and childcare centres, food and beverage sevice, place of public amusement, food processing industry, human body animal body and body surface, the sterilization killing microorganisms of surgery instrument and sterilization, cleaning and the health that various crowd fowl is raiseeed the intensive building surrounding enviroment of inhabitation activity.
Background technology
The rising of a lot of diseases, all be by microorganism grow and propagate the institute cause, often be enough to influence the each side of life, consider human beings'health, the health of animal, the safety of food and water, so that the safety of our surrounding enviroment, disinfectant has been widely used in all these aspects and field, in hospital from implementing of sterilization and the sterilization of strict various operation sequences to entire environment, at home the user then is used for clean hand sterilization, spraying disinfection, the embathing or adopt pasteurization towelette of the disinfecting cleaning of body surfaces such as wall, cabinet, table top and daily fruits and vegetables.Disinfectant also is used for the pasture, rural area widely, because the economic benefit that health of fowl poultry and disease can directly have influence on them.
The antibacterial agent chlorhexidine, benzalkonium chloride and the chlorine m-cresol used as antimicrobial component separately.Be used for cleaning sterilization, if use a small amount of above-claimed cpd, be difficult to make us believing that above-mentioned any sterilization lotion can be killed the pathogeny body effectively apace comprehensively, or adopt time expand and cycle to reach the sterilization functions of skin surface.If therefore prepare this too high class disinfectant of dose concentration, the irritation of skin can appear again repeatedly.
In the past, the mixing way that adopts one or more antimicrobials is just mentioned in following patent.
United States Patent (USP) NO.5244666.Sep.14.1993 speak of about a kind of antisepsis and sterilization lotion, exactly by quaternary ammonium salt compound with have a kind of that substituent oxybenzene compound is mixed with and when low concentration, can improve the report of antimicrobial acivity effect.This patent shows that above-mentioned mixing antimicrobial is used for the degrease emulsifier in combination, and washing agent is newer on skin soft agent and the placebo, and it comprises 3% (weight) quaternary amine and the substituent oxybenzene compound of 3% (weight) tool in conjunction with component.
The component that U.S. Patent No. 5030659.Jul.9.1991 relates to bactericide comprises quaternary ammonium salts, biguanides and phenol compound, the Cmax content that this antimicrobial showed be quaternary ammonium salt compound, the content of quaternary ammonium salt compound is 15～20% in the formula constituent that this patent exemplifies.
U.S. Patent No. 4900721.Feb.13.1990, the liquid disinfectant that this patent is spoken of is based on ethanol and hydrogen peroxide, wherein used alcohol is one or more two～eight carbon alcohol, and used hydrogen peroxide also can be a kind of compound that produces hydrogen peroxide.One or more carboxylic acids, one or more bactericidal itrogenous organic substances (as chlorhexidine or benzalkonium chloride), one or more bactericidal oxybenzene compounds (comprising that polychlorostyrene is for toluene).
U.S. Patent No. 4125628 and 4022911, Nov.14.1978 and May.10.1977. should be mentioned that quaternary ammonium salts, phenol or derivatives thereof, and the mixture of formaldehyde.The antimicrobial component that U.S. Patent No. 4420484.Dec.13.1983 speaks of is that chlorhexidine or benzalkonium chloride are with surfactant polyethylene betain or imino chloride surfactant.
What United States Patent (USP) patent No.3639632.Feb.1.1972 reported is to comprise about a kind of collaborative antimicrobial component: 1, and 1 '-hexylidene-two [5 (2-ethylhexyl) biguanides] hydrochloride and trichlorine 2-dihydroxy diphenyl ether.
A series of antimicrobial articles has been developed and has exemplified by research constantly, and these components can provide antimicrobial activity fast and effectively and not have skin irritatin etc. and pay effect.
The antibacterial disinfectant always continued to use for a long time of China mainly limits to and stays in some more outmoded products, as: the bleaching powder in the available chlorine chlorine-containing disinfectant, hypochlorite and chloramines etc.; The Peracetic acid of per-compound class, hydrogen peroxide; The iodoform of halide class, Iodophor, C5H6Br2N2O2; The benzene of quaternary ammonium salts is pricked chlorine (bromine) ammonium; The chlorinated phenol of phenol derivatives; And the most frequently used alcohol.All there is very big gap in these products with actual needs on kind, quality, output and practicality, as for concerning vast rural area, breach is then bigger, in addition, all the said goods almost all belong to single component product, and therefore not only sterilization spectrum is narrow, use limitation big, and partly product belongs to the dangerous material scope again, really can not be satisfactory.
By contrast, the sales volume of at present external antibacterial disinfectant is huge, and no matter from kind, quality and output from screening process, have been found the kind that some sterilizing activities are more stable all considerably beyond China.But blemish in an otherwise perfect thing is often only to have noted the advantage of single new product, and ignored reasonable combination, learn from other's strong points to offset one's weaknesses and component between compatibility, concertedness and synergistic effect.
Summary of the invention
Purpose of the present invention is exactly to provide a kind of for the defective that overcomes above-mentioned prior art existence to draft the prescription that has compatibility, concertedness and synergy between each component by microbial molecular is learned research, thereby has reached the polyploid Synergistic multifunctional broad-spectrum disinfectant and the application thereof of wide spectrum killing microorganisms effect.
Purpose of the present invention can be achieved through the following technical solutions:
A kind of polyploid Synergistic multifunctional broad-spectrum disinfectant, it is characterized in that, this disinfectant matrix formulations comprises (1) antimicrobial 0.05～4.5% weight, (2) quaternary ammonium salt compound 0.005～0.5% weight, (3) chlorophenol compounds 0.025～3% weight (4) alcohols 92～99.9% weight.
Described disinfectant matrix formulations comprises (1) antimicrobial 0.05～0.4% weight, (2) quaternary ammonium salt compound 0.005～0.1% weight, (3) chlorophenol compounds 0.025～0.3% weight, (4) alcohols 99.3～99.6% weight.
Described antimicrobial comprise be selected from chlorhexidine, chlorhexidine salt, polyhexamethylene biguanides and the malicious pyridine (Alexidine) that is situated between etc. in any.
Described quaternary ammonium salt compound comprise be selected from that benzalkonium chloride, benzalkonium bromide, chlorobenzene pine are peaceful, any in the hydrochloric acid cetyl pyridinium etc.
Described chlorophenol compounds comprises and is selected from any in chlorine m-cresol, the three chloro-2-dihydroxy diphenyl ethers etc.
Described alcohols comprises and is selected from any or several in ethylene glycol, propane diols, isopropyl alcohol, ethanol, the normal propyl alcohol.
Comprise also in the described prescription that water is as solvent.
A kind of described polyploid Synergistic multifunctional broad-spectrum Application of disinfectants is characterized in that this disinfectant matrix is mixed in and makes disinfectant soap in the common soap, perhaps is mixed in and makes the cosmetics with sterilization and anti-corrosion function in the cosmetics.
A kind of described polyploid Synergistic multifunctional broad-spectrum Application of disinfectants is characterized in that, paper handkerchief or cotton towel be impregnated in make the sterilization wet tissue in this disinfectant.
A kind of described polyploid Synergistic multifunctional broad-spectrum Application of disinfectants is characterized in that this disinfectant matrix can be made aqua, spray, emulsion, creme, gel disinfectant respectively by adding conventional auxiliary agent.
A kind of described polyploid Synergistic multifunctional broad-spectrum Application of disinfectants is characterized in that, the new method of a kind of antibacterial to skin and other body surfaces, the sterilization of adopting that effective dose in the disinfectant matrix formulations sets up.
The present invention drafts and the polynary prescription that adopts has than single prescription both domestic and external and two～ternary prescription and maximizes favourable factors and minimizes unfavourable ones, the advantage that brings out the best in each other, therefore sterilization spectrum is extremely wide, through implementing checking, removing all has very strong killing and deactivation to three major types (bacterium, virus, mould) pathogenic microorganisms, for example to the Gram-positive and the Gram-negative bacteria of bacterium class; To Candida albicans, the dermophyte of der Pilz, favus mould, first, second, third mould and the black-koji mould of sufficient branch mould, silk Pseudomonas; Especially to multiple more thorny virus, such as coronavirus, various hepatitis viruses, acute influenza virus, AIDS virus (HIV), herpes virus, Respiratory Syncytial Virus(RSV), cytomegalovirus, adenovirus, the enterovirus etc. that comprises polio all have very strong killing and deactivation.In addition, it is to multiple main venereal disease pathogeny body such as diplococcus, microspironema pallidum, trichomonas vaginalis, Candida albicans, condyloma acuminatum, Chlamydia, Jie's urea mycoplasma etc., and multiple pesticide resistance pathogeny body and protozoon, egg capsule worm etc. have stronger killing and deactivation equally.Based on the validity of polynary prescription of the present invention, also in order to the product of the sterilization formulation of making multiple targeted function, so its function of use also is many-sided.
Antibacterial disinfectant of the present invention removes outside the advantage with above-mentioned multi-functional, efficient, wide spectrum, and it also has following multiple characteristics:
1) nontoxic to human body, environmental sound, non-stimulated irritated to skin and mucous membrane with nothing.
2) there are not problems such as the lability of available chlorine class disinfectant and intense stimulus nose larynx.
3) there are not the sort of sharp sourness excitant of Peracetic acid class and lability.
4) there is not the oxidisability disinfectant the sort of because of consuming the active shortcoming of organic matter reduction itself simultaneously.
5) also can heavily cover the weakness that infects again after not existing alcohol to volatilize like that.
6) disinfectant prescription of the present invention has almost had the strong point of existing various disinfectants, but has overcome the deficiency and the shortcoming of various existing disinfectants.
7) can be used for the spraying sterilization of house, dormitory, building, hotel, catering service, school's interior spaces such as (classroom, dormitories) by the antibacterial disinfectant of formulation of the present invention; Can be used for furniture, cabinet, tables and chairs surface inside injection or clean; The sterilization of hand, arm and the surface of a wound when more can be used for operation.Use can be carried with the pasteurization towelette that it is made, in addition, also multiple formulations targetedly such as gel, creme and emulsion can be made.Not only having filled up the gap of existing market in view of the above, also is a kind of product that is subjected to the people to pay close attention to and welcome deeply.
Embodiment
The antimicrobial matrix formulations that the present invention relates to comprises a kind of biguanide compound, a kind of chlorophenol compounds, a kind of quaternary ammonium salt compound and one or more alcohols.
Wherein, the biguanide compound of employing can comprise, but be not limited to following multiple: chlorhexidine, the bis phosphoric acid chlorhexidine, two gluconic acid chlorhexidines, two chlorohaxanpyridine acetates, hydrochloric acid chlorhexidine, two chlorine chlorhexidines, the acid iodide chlorhexidine is crossed the chloric acid chlorhexidine, the nitric acid chlorhexidine, sulfuric acid chlorhexidine, sulfurous acid chlorhexidine, the thiosulfuric acid chlorhexidine, di-phosphino-chlorhexidine, two fluoro phosphoric acid chlorhexidines, two formic acid chlorhexidines, two propionic acid chlorhexidines, two iodo butyric acid chlorhexidines, two-n-valeric acid chlorhexidine, two caproic acid chlorhexidines, malonic acid chlorhexidine, the cinnamic acid chlorhexidine, malic acid chlorhexidine, tartaric acid chlorhexidine, two Monoethylene Glycol (MEG) chlorhexidines, monoethylene glycol chlorhexidine, dilactic acid chlorhexidine, two AHIB chlorhexidines, diethylene glycol (DEG) enanthic acid chlorhexidine, two different sulfuric acid chlorhexidines, two benzoic acid chlorhexidines, the salicylic acid chlorhexidine, two mandelic acid chlorhexidines, two different phosphorus benzene bis-acid potassium chlorhexidines, two Alpha-hydroxy naphthoic acid chlorhexidines, chlorine bromic acid chlorhexidine, polyhexamethylene biguanides and the malicious pyridine (Alexidine) that is situated between.
The quaternary ammonium salt compound that is adopted comprises, but is not limited to following several:
Benzalkonium chloride, the chlorobenzene pine is peaceful, other benzene are pricked the halogen ammonium, other halogeno-benzene pines are peaceful, the hydrochloric acid cetyl pyridinium, N-myristyl-N-methylmorpholine methylsulfuric acid salt compound, poly-[N-[3-(dimethylamine propane)-N-[3-(ethyleneoxy ethene dimethylamine) propane] dichloro-urea], α-4[1-three (2-ethoxy) ammonium chloride-2-butyl]-ω-three (2-ethoxy) ammonification amine, α-4-[1-three (2-ethoxy) ammonium chloride-2-butyl] poly-[1-dimethyl chlorination amine-2-butyl]-ω-three (2-ethoxy) ammonium chloride, poly-[ethylene oxy (dimethyleneimine base) ethene (dimethyleneimine base)-dichloroethylene], ethylhexyl decyl diformazan aminoethyl sulphate, ethyl sulfuric acid diformazan ammonia, dimethyl second benzyl sal-ammoniac, the dixylyl sal-ammoniac, the last of the ten Heavenly stems dimethyl ethyl ammonia bromide, and organosilicon replacement quaternary ammonium salt compound, such as 3-(the silica-based propyl group of trimethoxy-octadecyl diformazan sal-ammoniac.
The chlorophenol that is adopted includes, but are not limited to the chlorine m-cresol, trichlorine 2-dihydroxy diphenyl ether, 2-chlorophenol, the 3-chlorophenol, 4-chlorophenol, 2,4 dichloro benzene phenol, 2,4,6-trichlorophenol, 2,4,6,-T, 2,3,4, the 6-tetrachlorophenol, pentachlorophenol, 2,4, the 6-trichlororesorcinol, the alkyl chloride substituting phenol (comprises to alkyl phosphorus chlorophenol phosphine base parachlorophenol, dialkyl group-4-chlorophenol and trialkyl-4-chlorophenol), dichloro m-cresol, chloro cresols, phosphorus phenyl parachlorophenol, 3,4,6 trichlorophenol, 2,4,6,-Ts, 4-chloro-2-phenylphenol, 6-chloro-2-phenylphenol, phosphorus phenyl parachlorophenol and 2,4-two chloro-3,5-diethyl phenol.In practical application, more welcome is three chloro-2-dihydroxy diphenyl ethers, because of it does not have odour nuisance.In addition, chlorhexidine and three chloro-2-dihydroxy diphenyl ethers can form a kind of compound, thus can the long period be retained in skin or body surface, the active and effect of long-acting killing microorganisms is provided for us thus.
As for alcohols, then can select for use to comprise ethylene glycol, propane diols, ethanol, propyl alcohol and isopropyl alcohol, but be not limited to the alcohol of above-mentioned several kinds.
In a word, more specifically, the antimicrobial prescription that the present invention relates to but also be not limited only to mention in the above-mentioned prescription typical case or the representative.On acceptable degree, the present invention there is no certain restriction and regulation, and for example, during as a kind of abrasive cleaner of killing microorganisms, wherein the concentration of biguanide compound can be between 0.05～4.5% (unless otherwise prescribed, all % are weight).As selecting between no particular restriction, the concentration of biguanide compound can be between 0.05～1%, and more definite also is 0.05～0.1%.When being used for the disinfectant of different requirements, the consumption of biguanide compound can be determined concentration range as required, generally comprises following three kinds: (1) 1～4.5% (weight), (2) 0.05～1% (weight), (3) 0.05～0.1% (weight) in a word.
Equally, on pouplarity, wherein quaternary ammonium salt compound such as benzene bundle halogen ammonium or the peaceful consumption of halogeno-benzene pine can be between 0.005～0.5%.When specializing selection, benzene pricks the halogen ammonium or the peaceful concentration of halogeno-benzene pine can be between 0.005～0.1%.
As mentioned above, same, the concentration of chlorobenzene phenols can be between 0.025～3%, and when concrete the selection, its concentration can be between 0.05～0.25% or 0.025～0.1%.
A bit concrete again, the prescription of the present killing microorganisms provided by the invention of unrestricted option table can comprise (1) chlorhexidine, chlorhexidine salt, any compound 0.05～0.4% in the polyhexamethylene biguanides and the malicious pyridine (Alexidine) that is situated between etc.(2) quaternary ammonium salt compound 0.005～0.1%, (3) chlorophenol compounds 0.025～0.3%.What make us happy selection most in above three compounds is: the chlorhexidine in the biguanide compound, three chloro-2-dihydroxy diphenyl ethers in benzalkonium chloride in the quaternary ammonium salt compound and the chlorophenol compounds.
Why further comprising a kind of organic solvent one alcohols in the anti-microbial matrix prescription of the present invention is the solvability and the compatibility that can increase relevant antimicrobial, for example ethylene glycol, propane diols, isopropyl alcohol, ethanol or propyl alcohol.What the consumption of organic solvent was more suitable in the prescription is between 92～99.9% (weight), and generally speaking, the consumption that adopts 99.3% (weight) is a kind of selection preferably.
So far, another kind of very actual embodiment is the present invention provides a kind of disinfectant detergent again for other new disinfectant kind a scouring matrix, and compellently can increase the killing microorganisms effect.This matrix comprises 10～15% Propiram Buddhist nun and restrains copolymer, includes, but are not limited to the Propiram Buddhist nun and restrains F87; 1～5% amino oxide foaming agent comprises, but also is not limited to glucose amido DOE120; One or more antimicrobials; And water, the acid that the PH of matrix can be adjusted to the used gentleness of 5.5-6.0. with the acids of gentleness includes, but are not limited to the glucose lactones, lactic acid, salicylic acid, citric acid or glutaric acid etc.Optimum antimicrobial can comprise, but be not limited to parachlorometaxylenol, polyphenyl alcohol ether, Iodophor, chlorhexidine, chlorhexidine salt, benzalkonium chloride and their mixture.Isopropyl alcohol or propane diols then can be used as the solvability that guarantees antimicrobial.
Prescription of the present invention is gone back combining and is become various product, includes but not limited to the disinfectant such as hand, wash one's hands disappear clean dose (hand soaps) be used for the gel of epiderm skin sterilization, emulsion and creme, sterilization lotion or soaking agent, spray, goods such as pasteurization towelette.Equally, this prescription also can be admixed the preservative as multiple product, for example is used for cosmetics etc.
Purposes of the present invention and practicality can illustrate with the following example, certainly this part example that just proposes rather than the above and whole.Meanwhile, must be pointed out that various different product adopted in the market though antimicrobial activities concentration that this patent adopts is lower than, thereby had reduced skin irritant danger, but not influence the validity of killing microorganisms.
Embodiment 1
Biguanides, chlorobenzene phenols, the synergistic function of quaternary ammonium salt compound and alcohols.
Prepare the concentrate of the anti-microbial active matter of various combinations earlier,, press table 1, promptly get 0.1mL concentrate and 0.90mL and contain 10 to shown in the table 5 as the usefulness of further diluting (10 times)
7The S.A/mL bacterium liquid of CFU is mixed, and medium is 20% serum and 80%TSB composition, exposes and places after one minute, this culture fluid is diluted 100 times with LTSB, thereafter the above-mentioned dilution of 0.2mL is inoculated in the soy agar inclined-plane, cultivated 24 hours, and calculated clump count (table 1～5) then for 37 ℃.
Table 1
| Sample | A 1-1 | B 1-1 | C 1-1 | D 1-1 |
| Chlorhexidine % | 0 | 0.025 | 0.05 | 0.1 |
| Ethanol % | 5.0 | 5.0 | 5.0 | 5.0 |
| Phenoxyethanol % | 0.2 | 0.2 | 0.2 | 0.2 |
| Long bacterium (CFU/mL) | 5.1×10 7 | 3.0×10 7 | 1.8×10 7 | 4.9×10 6 |
Table 2
| Sample | A 1-2 | B 1-2 | C 1-2 | D 1-2 |
| Chlorhexidine % | 0 | 0.025 | 0.05 | 0.1 |
| Three chloro-2-dihydroxy diphenyl ether % | 0.025 | 0.025 | 0.025 | 0.025 |
| Ethanol % | 5.0 | 5.0 | 5.0 | 5.0 |
| Phenoxyethanol % | 0.2 | 0.2 | 0.2 | 0.2 |
| Long bacterium (CFU/mL) | 2.0×10 7 | 7.1×10 5 | 6.0×10 4 | 1.9×10 3 |
Table 3
| Sample | A 1-3 | B 1-3 | C 1-3 | D 1-3 |
| Chlorhexidine % | 0 | 0.025 | 0.05 | 0.1 |
| Three chloro-2-dihydroxy diphenyl ether % | 0.05 | 0.05 | 0.05 | 0.05 |
| Ethanol % | 5.0 | 5.0 | 5.0 | 5.0 |
| Phenoxyethanol % | 0.2 | 0.2 | 0.2 | 0.2 |
| Long bacterium (CFU/mL) | 2.0×10 6 | 1.0×10 5 | 9.9×10 4 | 0 |
Table 4
| Sample | A 1-4 | B 1-4 | C 1-4 | D 1-4 |
| Chlorhexidine % | 0 | 0.025 | 0.05 | 0.1 |
| Three chloro-2-dihydroxy diphenyl ether % | 0.1 | 0.1 | 0.1 | 0.1 |
| Ethanol % | 5.0 | 5.0 | 5.0 | 5.0 |
| Phenoxyethanol % | 0.2 | 0.2 | 0.2 | 0.2 |
| Long bacterium (CFU/mL) | 6.9×10 2 | 0 | 0 | 0 |
Table 5
| Sample | A 1-5 | B 1-5 | C 1-5 | D 1-5 | E 1-5 |
| Chlorhexidine % | 0 | 0.025 | 0.05 | 0.1 | 0.1 |
| Three chloro-2-dihydroxy diphenyl ether % | 0 | 0.05 | 0.05 | 0.05 | 0.025 |
| Benzalkonium chloride % | 0.02 | 0.02 | 0.02 | 0.02 | 0.02 |
| Ethanol % | 5.0 | 5.0 | 5.0 | 5.0 | 5.0 |
| Phenoxyethanol % | 0.2 | 0.2 | 0.2 | 0.2 | 0.2 |
| Long bacterium (CFU/mL) | 5.1×10 7 | 5×10 3 | 9.9×10 2 | 0 | 0 |
Embodiment 2
A kind of surface disinfection wet tissue.
The wet tissue that surface disinfection is used is with specific paper or the cotton goods of knitting behind the bactericide that sheet floods following prescription.
A
1-6Chlorhexidine 0.2% weight
Trichlorine 2-dihydroxy diphenyl ether 0.1% weight
Benzalkonium chloride 0.05% weight
Phenoxyethanol 0.1% weight
Ethanol 50% weight
Water 49.55% weight
B
1-6Parachlorometaxylenol 0.2% weight
Trichlorine 2-dihydroxy diphenyl ether 0.1% weight
Benzalkonium chloride 0.05% weight
Phenoxyethanol 0.1% weight
Ethanol 50% weight
Water 49.55% weight
Wet tissue is cut into 2cm
2Small pieces, applying light is in inoculation 0.3ML10
8(the c.a exception, its thalline liquid is 10 to CFU/mL bacterium liquid
6CFU/ml) six seconds of soy agar, remove wet tissue thereafter, agar slant was cultivated 2 hours for 37 ℃, calculate sterilization effect according to inhibition zone.The results are shown in Table 6. through contrasting with the wet tissue group of flooding parachlorometaxylenol, the wet tissue group of dipping chlorhexidine shows the fungistatic effect of wide spectrum.
Table 6
| Bacterium liquid | Inhibition zone | |
| A 1-6 | B 1-6 | |
| S.aureus | 50mm | 46mm |
| P.aeruginosa | 25mm | 0 |
| Enterobacter | 27mm | 25mm |
| E.Coli | 33mm | 30mm |
| C.albicans | 32mm | 27mm |
Embodiment 3
The ethanol/water composite substrate.
Following prescription can be used as a kind of quick disinfectant, for example is used for hand, intravenous site, and the preliminary treatment of surgical site, and the antimicrobial acivity of following prescription is through measuring, and the result is as follows.Matrix is to be prepared from by the second alcohol and water.
Ethanol matrix: 70% ethanol, 30% water
Put following A by above-mentioned ethanol based plasmogamy
1-7And B
1-7The prescription of antimicrobial:
A
1-7
Chlorohaxanpyridine acetate 0.05%
Three chloro-2-dihydroxy diphenyl ethers 0.1%
Benzalkonium chloride 0.1%
B
1-7
Chlorohaxanpyridine acetate 0.05%
Parachlorometaxylenol 0.2%
Benzalkonium chloride 0.1%
Above-mentioned prescription is through the determination of activity of anti-S.Aureus bacterium.Assay method is to contain 10 with 0.1mL
7The microbial culture medium of CFU/mL is seeded in the soy agar inclined-plane, the following prescription of 0.3mL is coated the agar slant of inoculation after 10 minutes again.
(1) A
1-7In the ethanol/water matrix group
(2) B
1-7In the ethanol/water matrix group
(3) Purell
Hand cleaning agent (GOJO company)
(4) ethanol/water matrix control group
(5) culture fluid control group
Purell
Be a kind of 60-70% of containing ethanol, the skin antiseptic of thickener and emollient.
Above-mentioned tested emulsion adds 2.7mL LTSB respectively and mixes evenly in agar surface through with after the agar slant of inoculating contacts one minute, takes out 0.1mL again with 0.9mL LTSB dilution, gets its 0.2mL thereafter and cultivates once more, measures clump count.The results are shown in Table 7.
Table 7
| Test formulations | The CFU/ inclined-plane |
| (1)A 1-7In the ethanol/water matrix group | 0 |
| (2)B 1-7In the ethanol/water matrix group | 0 |
| (3)Purell Hand cleaning agent (GOJO company) | 2.0×10 5 |
| (4) ethanol/water matrix control group | 5.0×10 5 |
| (5) culture fluid blank group | 2.0×10 6 |
What the present invention relates to is a kind of new antimicrobial prescription, and this prescription comprises: biguanide compound, chlorophenol compounds, quaternary ammonium salt compound, with one or more alcohols, this prescription is outstanding shows compatibility, concertedness and synergy between selected component.This is new multi-functional, the antimicrobial prescription of high-efficiency broad spectrum can be used for preparing antiseptic solution, the sterilization abluent, disinfectant soap, disinfecting gel, sterilization emulsion, the sterilization creme, pasteurization towelette, sterilization spray and sterilization irrigation also can extensively popularly be used for hospital, medical and health organization, various sanitarian place and the family expenses etc. of relating to.
Claims (8)
1. polyploid Synergistic multifunctional broad-spectrum disinfectant, it is characterized in that, this disinfectant matrix formulations comprises (1) antimicrobial 0.05～4.5% weight, (2) quaternary ammonium salt compound 0.005～0.5% weight, (3) chlorophenol compounds 0.025～3% weight, (4) alcohols 92～99.9% weight;
Wherein,
Described antimicrobial is selected from: chlorhexidine or chlorhexidine salt;
Described quaternary ammonium salt compound is selected from: benzalkonium chloride or benzalkonium bromide;
Described chlorophenol compounds is selected from: parachlorometaxylenol or three chloro-2-dihydroxy diphenyl ethers;
Described alcohols is selected from: one or more in ethanol, Phenoxyethanol, ethylene glycol, propane diols, isopropyl alcohol or the normal propyl alcohol.
2. a kind of polyploid Synergistic multifunctional broad-spectrum disinfectant according to claim 1, it is characterized in that, described disinfectant matrix formulations comprises (1) antimicrobial 0.05～0.4% weight, (2) quaternary ammonium salt compound 0.005～0.1% weight, (3) chlorophenol compounds 0.025～0.3% weight, (4) alcohols 99.3～99.6% weight.
3. a kind of polyploid Synergistic multifunctional broad-spectrum disinfectant according to claim 1 and 2 is characterized in that described disinfectant is the form of dilution or concentrate.
4. a kind of polyploid Synergistic multifunctional broad-spectrum disinfectant according to claim 3 is characterized in that described disinfectant prescription in weight % is:
Chlorhexidine: 0.2%; Three chloro-2-dihydroxy diphenyl ethers: 0.1%; Benzalkonium chloride: 0.05%; Ethanol: 50%; Phenoxyethanol: 0.1%; Water: 49.55%.
5. the described polyploid Synergistic of claim 1 multifunctional broad-spectrum Application of disinfectants, it is characterized in that, this disinfectant matrix is mixed in and makes disinfectant soap in the common soap, perhaps is mixed in and makes the cosmetics with sterilization and anti-corrosion function in the cosmetics.
6. the described polyploid Synergistic of claim 1 a multifunctional broad-spectrum Application of disinfectants is characterized in that, paper handkerchief or cotton towel be impregnated in make the sterilization wet tissue in this disinfectant.
7. the described polyploid Synergistic of claim 1 a multifunctional broad-spectrum Application of disinfectants is characterized in that, this disinfectant matrix can be made aqua, spray, emulsion, creme, gel disinfectant respectively by adding conventional auxiliary agent.
8. the described polyploid Synergistic of claim 1 a multifunctional broad-spectrum Application of disinfectants is characterized in that, the new method of a kind of antibacterial to skin and other body surfaces, the sterilization of adopting that effective dose in the disinfectant matrix formulations sets up.
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| CNB2003101091067A CN1328957C (en) | 2003-12-05 | 2003-12-05 | Multielement syneryistic multifunction broad spectrum disinfectant and its application |
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| CNB2003101091067A CN1328957C (en) | 2003-12-05 | 2003-12-05 | Multielement syneryistic multifunction broad spectrum disinfectant and its application |
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| CN1623394A CN1623394A (en) | 2005-06-08 |
| CN1328957C true CN1328957C (en) | 2007-08-01 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108850017A (en) * | 2018-05-03 | 2018-11-23 | 江苏医药职业学院 | A kind of wide spectrum and the disinfectant and preparation method thereof containing plant extract component |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895672B (en) * | 2006-06-22 | 2011-08-10 | 上海麟翔生物技术有限公司 | Multifunctional broad-spectrum obtundent of polyphyletic synergistic and its use |
| CN101953654A (en) * | 2010-04-19 | 2011-01-26 | 铜陵洁雅生物科技股份有限公司 | Sterilized clean wet napkin and preparation method thereof |
| CN102488705B (en) * | 2011-12-08 | 2013-08-21 | 施耐克江苏生物制药有限公司 | Skin mucous membrane disinfectant for killing virus |
| CN103340584A (en) * | 2013-07-17 | 2013-10-09 | 深圳市妍倩科技有限公司 | Wet tissue for kitchen cleaning and disinfection |
| CN103988842A (en) * | 2014-04-29 | 2014-08-20 | 金红叶纸业集团有限公司 | Antibacterial composition used for paper product and antibacterial paper |
| CN105875623A (en) * | 2016-06-15 | 2016-08-24 | 王兰英 | Disinfectant for glassware for test |
| CN106508946A (en) * | 2016-11-30 | 2017-03-22 | 河池市技术开发中心 | Rearing instrument disinfectant containing gluconic acid |
| CN112252033B (en) * | 2020-10-27 | 2021-05-11 | 广州泰达纤维制品有限公司 | Graft modified antibacterial plant fiber material and preparation method thereof |
| CN115299437A (en) * | 2021-05-06 | 2022-11-08 | 南顺商标有限公司 | Antimicrobial compositions and methods of making the same |
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| CN1221051A (en) * | 1997-10-13 | 1999-06-30 | 希巴特殊化学控股公司 | Process for treatment of textile materials with antimicrobial agent |
| CN1232665A (en) * | 1998-01-20 | 1999-10-27 | 伊西康公司 | Antimicrobial composition |
| CN1397168A (en) * | 2001-07-13 | 2003-02-19 | 周茜 | Composite disinfectant |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1221051A (en) * | 1997-10-13 | 1999-06-30 | 希巴特殊化学控股公司 | Process for treatment of textile materials with antimicrobial agent |
| CN1232665A (en) * | 1998-01-20 | 1999-10-27 | 伊西康公司 | Antimicrobial composition |
| CN1397168A (en) * | 2001-07-13 | 2003-02-19 | 周茜 | Composite disinfectant |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108850017A (en) * | 2018-05-03 | 2018-11-23 | 江苏医药职业学院 | A kind of wide spectrum and the disinfectant and preparation method thereof containing plant extract component |
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| CN1623394A (en) | 2005-06-08 |
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