CN106029053B - Dentifrice composition - Google Patents

Abstract

The foam that the present invention provides when brushing teeth is inhibited from the drippage in mouth, the butterfat sense of foam is also excellent and fragrance is high, to contain (A) Gao Juhe polyethylene glycol, (B) alkyl sulfate, (C) amphoteric surfactant and (D) nonionic surface active agent, (C) ingredient/(D) ingredient is 0.05~5 dentifrice composition being characterized by quality ratio, and, in the dentifrice composition for being mixed with above-mentioned (A) and (B) ingredient, with (C) ingredient/(D) ingredient in above-mentioned quality than mixing (C) and (D) ingredient in range, improve by (A) in above-mentioned dentifrice composition, (B) ingredient and with caused foam drippage method.

Description

Dentifrice composition

Technical field

The present invention relates to a kind of foams being able to suppress when brushing teeth to drip from mouth, and the butterfat sense of foam is also excellent, and fragrant The high dentifrice composition of taste.

Background technique

In the use feeling of dentifrice composition, the sense of touch of intraoral foam is to feel one of the quality for cleaning sense.So And due to salivating often in oral cavity, when especially brushing teeth for a long time, dentifrice composition is through saliva dilution, therefore leads It causes foam not lasting, assigns the effect reduction for cleaning true feeling, while foam being caused to drip from mouth, become to can not be felt foam Butterfat sense, the problem of causing the so-called satisfaction brushed teeth to reduce.

In addition, for the raising using satisfaction of dentifrice composition, the excellent degree of fragrance when starting to brush teeth It is critically important.It shows distinctive bitter taste however, having usually as the surfactant that foaming agent uses, it is to cause for masking The problem of expression power decline of offending taste and mixed fragrance.

Therefore, in dentifrice composition, it is difficult to improve foaming properties while being well maintained fragrance.

As the well known method for making the sense of touch of foam improve, improve use feeling, propose by mixing silicic acid anhydride, beet Alkaline amphoteric surfactant, l-menthol and menthyl ester, thus in imparting foaming characteristic and with skin texture (texture) exquisiteness While true feeling is washed in the cleaning of froth texture, inhibits bitter taste, the peculiar smell in use, make technical solution (patent salubrious in mouth Document 1: Japanese patent special table 2011-105647 bulletin).But the patent document 1 does not mention foam to drip from mouth.

On the other hand, in the field of oral cavity, although polyethylene glycol is normally used as moisturizer or thickener uses, The example that average molecular weight is mixed in preparation in 50,000 especially 100,000 or more high polymerization polyethylene glycol is less.It has been proposed Following scheme: for improving the example (patent document 2: Japanese patent special table 2006- of the frothing capacity of liquid toothpaste composition No. 506359 bulletins), (patent document 3: Japan is specially for the example of the dentifrice composition excellent for the remineralization facilitation effect of tooth Sharp special open 2013-112613 bulletin), and pass through high polyethylene glycol and alkyl sulfate and the thickening silica of polymerizeing Mixing improves foaming characteristic, the duration of foam and the technology (patent document 4: International Publication No. 10/ of butterfat sense when brushing teeth No. 073975).But these patent documents 2~4 do not mention the fragrance of dentifrice composition.

Existing technical literature

Patent document

1 Japanese patent special table 2011-105647 bulletin of patent document

2 Japanese patent special table 2006-506359 bulletin of patent document

3 Japanese Patent Laid-Open 2013-112613 bulletin of patent document

Patent document No. 10/073975 bulletin of 4 International Publication No.

Summary of the invention

Subject to be solved by the invention

Therefore, it is necessary to one kind to improve foaming properties while be well maintained fragrance in dentifrice composition, especially steeps The technology of foam drippage.

The present invention completes, and it is an object of the present invention to provide one kind is able to suppress foam when brushing teeth drips from mouth in view of the foregoing It falls, the butterfat sense of foam is also excellent, and the dentifrice composition that fragrance is high.

The means solved the problems, such as

The present inventor in order to achieve the above object, by concentrating on studies, as a result, it has been found that, by polymerizeing poly- second containing (A) is high Glycol, (B) alkyl sulfate, (C) amphoteric surfactant, (D) nonionic surface active agent make (C) ingredient/(D) ingredient It is by quality ratio 0.05~5, foam when so as to obtain brushing teeth is dripped from mouth to be suppressed, and the butterfat sense of foam is also excellent It is different, and the dentifrice composition that fragrance is high.

That is, being used in dentifrice composition and with mixing (A) ingredient and when (B) ingredient especially for further increasing Sense and when increasing the combined amount of (A) ingredient and (B) ingredient, can generate and generate foam drippage when brushing teeth, the fragrance change of potpourri The project of difference.Therefore, further progress research as a result, it has been found that, while by (A) ingredient and (B) at subassembly, combination (C), (D) ingredient when making (C)/(D) than for ratio appropriate, can completely eliminate the above subject, and foam drippage is inhibited, foam Butterfat sense also improve, and excellent fragrance can be assigned.It moreover has been found that especially mixing selected from peppermint system, spice system with And the fragrance of fruit system as (E) fragrance when, fragrance is more excellent.Therefore, dentifrice composition of the invention is that foam is difficult when brushing teeth To drip from mouth, the foam that can moderately keep in mouth is assigned, the butterfat sense of foam also improves, and the fragrance of potpourri is high, The excellent dentifrice composition of use feeling can assign true feeling of adequately brushing teeth, using satisfaction.

Therefore, the present invention provides the ameliorative way of the drippage of the foam in following dentifrice composition and dentifrice composition.

〔1〕

A kind of dentifrice composition, which is characterized in that contain (A) Gao Juhe polyethylene glycol, (B) alkyl sulfate, (C) both sexes Surfactant and (D) nonionic surface active agent, (C) ingredient/(D) ingredient is 0.05~5 by quality ratio.

〔2〕

The dentifrice composition recorded such as (1), wherein the high polymerization polyethylene glycol of (A) ingredient passes through Brookfield viscometer The viscosity of 5W/V% aqueous solution at 25 DEG C of (Brookfield viscosimeter) measurement is 10mPas or more, and by described viscous The viscosity of 2W/V% aqueous solution when degree counts 25 DEG C of measurement is 800mPas or less.

〔3〕

The dentifrice composition recorded such as (1) or (2), wherein (C) ingredient is glycine betaine system amphoteric surfactant.

〔4〕

The dentifrice composition recorded such as (1), (2) or (3), wherein the glycine betaine system amphoteric surfactant of (C) ingredient is Fatty acid amide propyl glycine betaine and/or 2- alkyl-N- carboxymethyl-N- hydroxyethyl imidazole glycine betaine.

〔5〕

Such as the dentifrice composition of any record of (1)~(4), wherein (D) ingredient is that the average addition of ethylene oxide rubs The Crodaret that your number is 20~40.

〔6〕

As (1)~(5) any record dentifrice composition, wherein containing 0.05~0.5 mass % of (A) ingredient, (B) 1~3.5 mass % of ingredient, 0.05~1 mass % of (C) ingredient, 0.1~3 mass % of (D) ingredient.

〔7〕

Such as the dentifrice composition of any record of (1)~(6), wherein further contain 0.5~2.5 matter of (E) fragrance Measure %.

〔8〕

One kind as (A) in dentifrice composition, (B) ingredient and ameliorative way that foam caused by using drips, feature Be, in the dentifrice composition for being mixed with (A) Gao Juhe polyethylene glycol and (B) alkyl sulfate, with (C) ingredient/ (D) ingredient is 0.05~5 range mixing (C) amphoteric surfactant and (D) non-ionic surfactant by quality ratio Agent.

〔9〕

As (8) record as (A) in dentifrice composition, (B) ingredient and ameliorative way that foam caused by using drips, Wherein, the viscosity of the 5W/V% aqueous solution when height of (A) ingredient polymerize 25 DEG C that poly- diethanol is measured by Brookfield viscometer is 10mPas or more, and the viscosity of 2W/V% aqueous solution at measured by the viscosimeter 25 DEG C is 800mPas or less.

〔10〕

As (8) or (9) record as (A) in dentifrice composition, (B) ingredient and improvement that foam caused by using drips Method, wherein mixing 0.05~0.5 mass % of (A) ingredient, 1~3.5 mass % of (B) ingredient, 0.05~1 matter of (C) ingredient Measure %, 0.1~3 mass % of (D) ingredient.

〔11〕

As (8), (9) or (10) record as (A) in dentifrice composition, (B) ingredient and foam drippage caused by using Ameliorative way, wherein further mixing 0.5~2.5 mass % of (E) fragrance.

The effect of invention

In accordance with the invention it is possible to foam when providing a kind of brush teeth is dripped from mouth to be inhibited, the butterfat sense of foam It is excellent, and the dentifrice composition that fragrance is high.The dentifrice composition can assign true feeling of adequately brushing teeth, using satisfaction.

Specific embodiment

Hereinafter, the present invention will be described in further detail.Dentifrice composition of the invention contains (A) high poly- second two of polymerization Alcohol, (B) alkyl sulfate, (C) amphoteric surfactant, (D) nonionic surface active agent, (C) ingredient/(D) ingredient ratio Example is particular range.

(A) the high polymerization polyethylene glycol of ingredient preferably has the high-molecular compound of polymerised glycol resulting structures, passes through Brookfield viscometer measurement 25 DEG C when 5W/V (mass/volume (capacity)) % aqueous solution viscosity in 10mPas or more, and And the viscosity of 2W/V% aqueous solution at measured by above-mentioned viscosimeter 25 DEG C is in 800mPas or less.

When the viscosity of 5W/V% aqueous solution is more than 20,000mPas, since viscosity can not be measured, therefore 2W/V% water is used Viscosity in solution.That is, Gao Juhe polyethylene glycol preferably has the viscosity physical property of following (1) or (2) in the present invention.

The viscosity of 5W/V% aqueous solution at (1) 25 DEG C is 10~20,000mPas.

(2) when the viscosity in (1) is more than 20,000mPas, the viscosity of 2W/V% aqueous solution at 25 DEG C is in 800mPa S or less.

In the present invention, the viscosity of 5W/V% aqueous solution when more preferably height polymerize 25 DEG C of polyethylene glycol is 10~18, 000mPas, particularly preferred 30~10,000mPas, particularly preferred 55~2,000mPas.

In the present invention, (A) ingredient is used as by using high polymerization polyethylene glycol of the viscosity in above-mentioned particular range, it can Fully facilitate the improvement that foam is dripped from mouth, further increases the butterfat sense of foam.

When the viscosity of above-mentioned 5W/V% aqueous solution is less than 10mPas, existing facilitates foam with being unable to fully drips from mouth The improvement fallen, the situation of the improvement effect difference of the butterfat sense of foam；The viscosity of above-mentioned 2W/V% aqueous solution is more than 800mPas When, there is not only fragrance variation, but also the case where the stability decline of dentifrice composition.

As the high polymerization polyethylene glycol of (A) ingredient, can be used it is following shown in commercially available product.

·POLYOX WSR N-10

(Dow Chemical's system, the viscosity of 5W/V% aqueous solution: 12~50mPas, sensing equipment: Brookfield RVT, rotor No.1, revolving speed 50rpm, 25 DEG C of measuring temperature, minute 0.5 divides)

·POLYOX WSR N-80

(Dow Chemical's system, the viscosity of 5W/V% aqueous solution: 55~115mPas, sensing equipment: Brookfield RVT, rotor No.1, revolving speed 50rpm, 25 DEG C of measuring temperature, minute 0.5 divides)

·POLYOX WSR N-750

(Dow Chemical's system, the viscosity of 5W/V% aqueous solution: 1,000~1,200mPas, sensing equipment: Brookfield RVT, rotor No.2, revolving speed 10rpm, 25 DEG C of measuring temperature, minute 1 divides)

·POLYOX WSR-205

(Dow Chemical's system, the viscosity of 5W/V% aqueous solution: 4,500~8,800mPas, sensing equipment: Brookfield RVT, rotor No.2, revolving speed 2rpm, 25 DEG C of measuring temperature, minute 5 divides)

·POLYOX WSR-1105

(Dow Chemical's system, the viscosity of 5W/V% aqueous solution: 8,800~17,600mPas, sensing equipment: Brookfield RVT, rotor No.2, revolving speed 2rpm, 25 DEG C of measuring temperature, minute 5 divides)

·POLYOX WSR N-12K

(Dow Chemical's system, the viscosity of 2W/V% aqueous solution: 400~800mPas, sensing equipment: Brookfield RVT, rotor No.1, revolving speed 10rpm, 25 DEG C of measuring temperature, minute 1 divides)

(A) the combined amount preferred composition of Gao Juhe polyethylene glycol it is whole 0.05~0.5% (quality %, similarly hereinafter.), more It is preferred that 0.1~0.3%.When combined amount is 0.05% or more, it can fully improve foam from the drippage in mouth, it can be fully Improve the butterfat sense of foam.From the aspect of inhibiting fragrance to be deteriorated, preferably 0.5% or less.

(B) alkyl sulfate is mixed in the present invention as anionic surfactant.

As (B) alkyl sulfate, the sodium alkyl sulfates such as NaLS, myristyl sulfate can be used, from From the aspect of fragrance, more preferable NaLS.Specifically, NaLS (eastern nation's chemical industry strain can be used Formula commercial firm system；NaLS), myristyl sulfate (Nikko Chemicals Co., Ltd's system；NIKKOL SMS) etc..

(B) 1~3.5%, more preferable the 1.5~2.5% of the combined amount preferred composition entirety of alkyl sulfate.Combined amount At 1% or more, the butterfat sense of foam can be improved.From the aspect of inhibiting fragrance to be deteriorated, preferably 3.5% or less.Into one Step ground, from preventing the foaminess of dentifrice composition to be excessively increased, foam is dripped from mouth becomes serious, and prevents oral cavity from really feeling From the aspect of feeling that the use feelings such as stimulation are deteriorated, preferably combined amount will not be excessive, and preferably 3.5% or less.

As (C) amphoteric surfactant, glycine betaine system amphoteric surfactant can be suitably mixed.

As glycine betaine system amphoteric surfactant, fatty acid amide propyl glycine betaine, 2- alkyl-N- carboxylic first can be enumerated Base-N- hydroxyethyl imidazole glycine betaine etc., the carbon atom number of the alkyl of the preferably described glycine betaine system amphoteric surfactant is 8~ 18.The fatty acid amide propyl glycine betaine that the carbon atom number of particularly preferred fatty acid is 8~18, wherein examined in terms of fragrance Consider, more preferable fatty acid distribution of coconut oil amido propyl betaine.

(C) commercially available product can be used in amphoteric surfactant, can specifically enumerate following products.

Fatty acid distribution of coconut oil amido propyl betaine (EVONIC corporation；TEGO BETAIN CK OK)

2- alkyl-N- carboxymethyl-N- hydroxyethyl imidazole glycine betaine (Lion Corporation's system；ENAGICOL C-40H)

Butterfat sense and foam from foam is from the aspect of the excellent degree of drippage and fragrance in mouth, (C) both sexes It is preferably whole 0.05~1%, more preferable 0.1~1% of composition that the combined amount of surfactant, which is scaled pure content, into one Step preferably 0.1~0.5%.At 0.05% or more, the butterfat sense of foam improves combined amount, can further suppress foam from mouth Middle drippage.From inhibiting the foaminess of dentifrice composition to be excessively increased, foam is from the aspect of drippage becomes serious in mouth, preferably 1% or less.Further, the generation of the distinctive bitter taste of amphoteric surfactant in order to prevent, it is also preferred that 1% or less.

As (D) nonionic surface active agent, particularly preferred Crodaret, more preferable ethylene oxide Average addition molal quantity is 20~40, specifically for 20 Crodaret.

As Crodaret, polyoxyethylene (40) rilanit special (nihon emulsion Co., Ltd. can be enumerated System: EMALEX HC-40, the average addition molal quantity 40 of ethylene oxide), polyoxyethylene (20) rilanit special (nihon emulsion strain Formula commercial firm system: EMALEX HC-20, the average addition molal quantity 20 of ethylene oxide) etc..

Butterfat sense and foam from foam from the aspect of the excellent degree of drippage and fragrance in mouth, (D) it is non-from The combined amount of subtype surfactant is preferably whole 0.1~3%, more preferable 0.2~1.5% of composition.Combined amount exists When 0.1% or more, the butterfat sense of foam is improved, and can be further suppressed foam and be dripped from mouth.From the side for inhibiting fragrance to be deteriorated Face consideration, preferably 3% or less.

In the present invention, by together with (B) alkyl sulfate combine (C) amphoteric surfactant and (D) it is non-ionic Surfactant makes (C)/(D) ratio in particular range as surfactant, so as to inhibit foam drippage, improve The butterfat sense of foam and improve fragrance.

In this case, mixed proportion (C)/(D) of (C) amphoteric surfactant and (D) nonionic surface active agent It by quality ratio, is 0.05~5, preferably 0.1~5, more preferable 0.1~3, further preferred 0.5~1.5.Within the above range When, the presence or absence of foam is dripped from mouth, the butterfat sense of foam, fragrance are excellent.When less than 0.05, fragrance is deteriorated.When more than 5, tooth The foaminess of composite cream is excessively increased, and while damaging the butterfat sense of foam, foam becomes serious from the drippage in mouth.

In the present invention, comprising (B), (C), (D) ingredient surfactant total content be composition it is whole 1.15~ 7.5%, particularly preferred 1.5~5.2%, especially particularly preferred 2~4%.When in the range, foam drop can be further suppressed It falls, the butterfat sense of foam is also more excellent.In addition, fragrance further increases.Further, in this case, from inhibition toothpaste The foaminess of composition is excessively increased, and foam drippage becomes serious, from the aspect of furthermore fragrance being inhibited to be deteriorated, preferred total content Without excessive.Further, in order to inhibit the bitter taste from surfactant, it is also preferred that total content is not excessive.

In addition, in the present invention, in the range of lossless effect of the invention, can also mix as needed (B), (C), (D) surfactant other than ingredient.Specifically, the anionic surfactant other than alkyl sulfate, such as can enumerate The N- acyl group sarcosine hydrochlorate such as N- sodium lauroyl sarcosine, N- myristoyl-N-methylaminoacetic acid sodium, N- acyl glutamate, N- methyl- N acyl methyltaurin sodium, N- methyl-N- acylalaninies sodium, alpha-olefin sodium sulfonate etc..When mixing these surfactants, preferably It is mixed in the range of the total content of above-mentioned surfactant.

Dentifrice composition of the invention, further preferably (E) fragrance.As fragrance, can be used alone or group Close natural perfume material that two or more is added used as common dentifrice with fragrance and by the perfume (or spice) of natural perfume material working process Material and single fragrance, there are also well known spice materials used in the Dentrifice compositions such as potpourri.In this case, In the present invention, even and if with mixing (A), (B) ingredient, also the fragrance of potpourri can be made to give full play to.As preferred fragrance, Peppermint system fragrance, spice system fragrance, fruit system fragrance can be enumerated, when using these, more particularly to obtain good fragrance.

From the aspect of the excellent degree of fragrance, the combined amount of the fragrance of (E) ingredient is preferably whole 0.5 of composition ~2.5%, more preferable 0.8~1.8%.The more fragrance of combined amount more improve, and can assign good perfume (or spice) when mixing 0.5% or more Taste.From the aspect of inhibiting fragrance to be deteriorated, preferably 2.5% or less.When combined amount is excessive, fragrance can not be well maintained by existing The case where.

In dentifrice composition of the invention, in addition to the above ingredients, in the range of not interfering effect of the invention also It can according to need the other well known ingredient of mixing.For example, can be with mixed-abrasive, thickener, binder, further as needed It can be with mixing sweetener, colorant, preservative, effective component etc..In addition, combined amount is in the range for not interfering effect of the invention It inside can be amount commonly.

As grinding agent, the silica-based grinding agent such as silica gel, precipitated silica, alumina silicate, zirconium silicate, phosphorus can be enumerated Sour hydrogen calcium dihydrate and without the series of calcium phosphate grinding agent such as hydrate, calcium phosphate, tetracalcium phosphate, calcium pyrophosphate, calcium carbonate, hydrogen Aluminium oxide, aluminium oxide, zeolite, hydroxyapatite, synthetic resin system grinding agent etc..The combined amount of these grinding agents, usually group Close 2~50%, especially the 10~30% of object entirety.

As thickener, the sugar alcohols such as D-sorbite, xylitol, the polyalcohols such as glycerol, propylene glycol etc. can be enumerated.In addition, flat Average molecular weight is the polyethylene glycol of 190~2,000 (medicine part outer article raw material standard record average molecular weight), due to high score The compatibility of (A) ingredient of son is good, thus under water phase swelling, can properly use from the aspect of dispersion.These increase Thick dose of combined amount is preferably generally whole 5~50%, particularly preferred 20~45% of composition.

As binder, organic or inorganic binder can be mixed.Specifically, sodium carboxymethylcellulose, methyl can be enumerated The cellulose derivatives such as cellulose, hydroxymethyl cellulose, cationized cellulose, the alginic acid such as mosanom, propylene glycol alginate spread out Biology, the natural gum class such as xanthan gum, karaya gum, Arabic gum, Sodium Polyacrylate, carboxy vinyl polymer, gather polyvinyl alcohol The organic binders such as vinylpyrrolidone, carragheen, gelation silica, gelation aluminium silica, aluminium-magnesium silicate (Veegum), the inorganic binders such as synthetic soapstone.The combined amount of binder is usually 0.1~10%, particularly preferred 0.5~ 5%.

As sweetener, saccharin sodium, stevioside, stevia extract etc. can be enumerated.As colorant, can enumerate Amaranth, No. 3, No. 225, No. 226, yellow 4, No. 5, blue No. 1, No. 2, mica titanium, titanium oxide etc..

As preservative, the p-hydroxybenzoates such as methyl p-hydroxybenzoate, ethyl-para-hydroxybenzoate, benzene can be enumerated The benzoic acid such as sodium formate or its salt etc..

As effective component, can usually be mixed in the range of not interfering effect of the invention with effective quantity mixing Known ingredient, such as fungicide, anti-inflammatory agent, enzyme, fluoride, copper compound, vitamins, plant extracts, anti-tooth can be enumerated Stone agent, anticalculus agent etc..

Specifically, the non-ionic fungicide such as isopropyl methyl phenol can be enumerated, Cetylpyridinium Chloride, hydrochloric acid chlorhexidine, benzene are pricked The cationics fungicide such as oronain, benzethonium chloride, tranexamic acid, ε-aminocaproic acid, allantoin, enoxolone, dipotassium glycyrrhizinate Equal anti-inflammatory agents, dextranase become the enzymes such as dextranase, amylase, protease, and the fluorides such as sodium fluoride, sodium monofluorophosphate are water-soluble The copper compounds such as phosphate cpd, copper gluconate, the inorganic salts such as potassium nitrate, aluctyl, zinc chloride, zinc citrate, strontium chloride, The vitamins such as ascorbic acid, tocopherol acetate, plant extracts etc..

Embodiment

Hereinafter, display embodiment and comparative example, Formulation Example, the present invention is specifically described, but the invention is not limited to Following embodiments.In addition, % indicates quality % when being not particularly limited in following examples.

[embodiment, comparative example]

The dentifrice composition (toothpaste) of component shown in table 1~3 is prepared by a conventional method, is evaluated with following methods. As a result it is recorded in table together.

(1) foam in brushing teeth drips the evaluation method of (difficulty of foam drippage) from mouth

The panel member of 10 people squeezes out the dentifrice composition for being filled in laminated tube on 1cm to commercially available product toothbrush, carries out 3 Minute brushes teeth, and about the foam in brushing teeth from the drippage in mouth, obtains " dripping without foam ", " has the foam of denier to drip But be not a problem ", " slightly having foam drippage ", " foam drippage " 4 stages answer.In the answer, " will not there is no foam Drippage " be used as 4 points, " have denier foam drip but be not a problem " as 3 points, " slightly having foam drippage " as 2 points, " foam drippage " is used as 1 point, is determined.

According to the average mark of 10 people, it will ensure that the toothpaste for the evaluation of ◎ and zero is judged as and brushes teeth according to following benchmark It can feel the dentifrice composition that foam is difficult to drip from mouth.

Evaluation criteria

◎: average mark is at 3.5 points or more 4.0 points or less

Zero: average mark divides at 3.0 points or more less than 3.5

△: average mark divides at 2.0 points or more less than 3.0

×: average mark divides at 1.0 points or more less than 2.0

(2) evaluation method of the butterfat sense of the foam in brushing teeth

The panel member of 10 people squeezes out the dentifrice composition for being filled in laminated tube on 1cm to commercially available product toothbrush, carries out 3 Minute brushes teeth, about the butterfat sense of the foam in brushing teeth, with reference substance (except without containing (A) Gao Juhe polyethylene glycol, (C) both sexes Other than surfactant, (D) nonionic surface active agent, dentifrice composition identical with the component of embodiment 1) compared with, it obtains To " raising ", " slightly improve ", " denier raising ", " not improving " 4 stages answer.In the answer, " it will mention It is high " 4 points are used as, " slightly improving " is used as 1 point as 2 points, " not improving " as 3 points, " denier raising ", is determined.

According to the average mark of 10 people, will ensure that the toothpaste for the evaluation of ◎ and zero is judged as according to following benchmark can feel The dentifrice composition improved to the butterfat sense for middle foam of brushing teeth.

Evaluation criteria

◎: average mark is at 3.5 points or more 4.0 points or less

Zero: average mark divides at 3.0 points or more less than 3.5

△: average mark divides at 2.0 points or more less than 3.0

×: average mark divides at 1.0 points or more less than 2.0

(3) evaluation method of the fragrance in brushing teeth

The panel member of 10 people squeezes out the dentifrice composition for being filled in laminated tube on 1cm to commercially available product toothbrush, carries out 3 Minute brushes teeth, and about the fragrance in brushing teeth, obtains the answer in 4 stages of " very good ", " good ", " slightly worse ", " poor ".In this time In answering, 4 points " very good " will be used as, it is " good " as 3 points, it is " slightly worse " as 2 points, it is " poor " as 1 point, determined.

According to the average mark of 10 people, it will ensure that the toothpaste for the evaluation of ◎ and zero is judged as and brushes teeth according to following benchmark The good dentifrice composition of fragrance.

Evaluation criteria

◎: average mark is at 3.5 points or more 4.0 points or less

Zero: average mark divides at 3.0 points or more less than 3.5

△: average mark divides at 2.0 points or more less than 3.0

×: average mark divides at 1.0 points or more less than 2.0

Use being detailed below for raw material.In addition, the viscosity of high polymerization polyethylene glycol is same as described above, it is to pass through Bu Shi Viscosimeter (Brookfield RVT or RVF) measurement 25 DEG C when viscosity.In addition, the poly- second two measured by the same method The viscosity of the 5W/V% of alcohol 4000 is less than 10mPas.

Height polymerization polyethylene glycol:

POLYOX WSR N-80

(Dow Chemical's system, the viscosity of 5W/V% aqueous solution: 85mPas (rotor No.1, revolving speed 50rpm, when measurement Between 0.5 point))

POLYOX WSR N-10

(Dow Chemical's system, the viscosity of 5W/V% aqueous solution: 35mPas (rotor No.1, revolving speed 50rpm, when measurement Between 0.5 point))

POLYOX WSR N-750

(Dow Chemical's system, the viscosity of 5W/V% aqueous solution: 1,100mPas (rotor No.2, revolving speed 10rpm, survey Fix time 1 point))

POLYOX WSR N-12K

(Dow Chemical's system, the viscosity of 2W/V% aqueous solution: 420mPas (rotor No.1, revolving speed 10rpm, measurement Time 1 divides))

Macrogol 4000 (compares ingredient)

(Sanyo's chemical conversion industry corporation, the average molecular weight 2,600~3 that medicine part outer article raw material standard 2006 is recorded, 800)

NaLS

(Dong Bang chemical industrial company system)

Myristyl sulfate

(Nikko Chemical Company system)

Fatty acid distribution of coconut oil amido propyl betaine

(TEGO BETAIN CK OK, EVONIC corporation)

2- alkyl-N- carboxymethyl-N- hydroxyethyl imidazole glycine betaine

(ENAGICOL C-40H, lion king corporation)

Polyoxyethylene (40) rilanit special

(ethylene oxide be averaged addition molal quantity 40, EMALEX HC-40, nihon emulsion corporation)

Polyoxyethylene (20) rilanit special

(ethylene oxide be averaged addition molal quantity 20, EMALEX HC-20, nihon emulsion corporation)

In addition, fragrance A-1~A-3, B-1, B-2, C composition details table 5~11 as be described hereinafter shown in.

[table 1]

[table 2]

[table 3]

Formulation Example is as described in Table 4.These dentifrice compositions are all that foam is difficult to drip, and the butterfat sense of foam is excellent, The good dentifrice composition of fragrance.

[table 4]

[table 5]

[table 6]

*: mass parts, similarly hereinafter.

[table 7]

Essence 2 (spice)
		Fennel oil	1
Eucalyptus oil	1
		Cinnamon oil	1
Caryophyllus oil	1
		Thyme linaloe oil	1
Sage oil	1
		Cardamom oil	1
Coriander oil	1
		Rosemary oil	1
Oreodaphene	1
		Oil of chamomile	1
Caraway seed oil	1
		Basil	1
Alcohol	1
		It is total	14 parts

[table 8]

Essence 3 (other essential oils)
		Wintergreen	1
Frankincense oil	1
		Lavender oil	1
Neroli oil	1
		Citronella oil	1
Jasmine oil	1
		Attar of rose	1
Rose absolute	1
		Vanilla absolute oil	1
Mango absolute oil	1
		Concrete of iris	1
Flores aurantii	1
		American mint absolute oil	1
Alcohol	1
		It is total	14 parts

[table 9]

Essence 4 (true feeling raw material)
		Menthyl acetate	1
N- substitution-p- terpane -3- formamide	1
		3-l- peppermint oxygroup propyl -1,2- glycol	1
Menthyl glyceryl ether	1
		Affinin	1
Monomenthyl succinate	1
		Linalool oxide	1
Vanillyl butyl ether	1
		Isopulegone	1
Pepper extract	1
		Oleoresin ginger	1
Pepper oleoresin	1
		Capsicum oleoresin	1
Alcohol	1
		It is total	14 parts

[table 10]

Essence 5 (flavor agent)
		Menthol	1
Ethylmaltol	1
		Vanillic aldehyde	1
Ethyl vanillin	1
		Furanone	1
Ethylcyclopentenolone	1
		Methyl cyclopentenyl ketone	1
2-Methyl Butyric Acid	1
		Propionic acid	1
P- methoxycinnamic aldehyde	1
		Fatty acid glyceride	1
It is total	11 parts

[table 11]

Essence 6 (fruit single-item)
		Cis- -3- hexenol	1
Trans- -2- hexenoic aldehyde	1
		Undecalactone	1
Decalactone	1
		Ethyl butyrate	1
Isoamyl acetate	1
		Benzaldehyde	1
Hexyl acetate	1
		Ethyl 2-methylbutyrate	1
Benzyl alcohol	1
		Alpha-terpineol	1
Bergamio	1
		Glycidic acid phenethyl ester	1
Benzyl carbinol	1
		Allyl hexanoate	1
Octanol	1
		Methyl cinnamate	1
Heptyne carboxylate methyl ester	1
		Irisone	1
Propane thioic acid ethyl-β-menthyl ester	1
		Cis- -6- nonenol	1
Watermelon ketone	1
		Jasmonic menthyl ester	1
Propylene glycol	2
		It is total	25 parts

Claims (9)

1. a kind of dentifrice composition, which is characterized in that contain (A) Gao Juhe polyethylene glycol, (B) alkyl sulfate, (C) both sexes table Face activating agent and (D) nonionic surface active agent, (C) ingredient/(D) ingredient is 0.05~5 by quality ratio,

(A) combined amount of Gao Juhe polyethylene glycol is 0.05~0.5 mass % of entire composition,

(A) Gao Juhe polyethylene glycol measured by Brookfield viscometer 25 DEG C when the viscosity of 5W/V% aqueous solution be 10mPas More than, and the viscosity of 2W/V% aqueous solution at measured by the viscosimeter 25 DEG C be 800mPas hereinafter,

(D) nonionic surface active agent is Crodaret.

2. dentifrice composition as described in claim 1, wherein (C) ingredient is glycine betaine system amphoteric surfactant.

3. dentifrice composition as claimed in claim 1 or 2, wherein the glycine betaine system amphoteric surfactant of (C) ingredient is rouge Fat acid amido propyl betaine and/or 2- alkyl-N- carboxymethyl-N- hydroxyethyl imidazole glycine betaine.

4. dentifrice composition as claimed in claim 1 or 2, wherein (D) ingredient is that the average addition molal quantity of ethylene oxide is 20~40 Crodaret.

5. dentifrice composition as claimed in claim 1 or 2, wherein contain 1~3.5 mass % of (B) ingredient, (C) ingredient 0.05 ~1 mass %, 0.1~3 mass % of (D) ingredient.

6. dentifrice composition as claimed in claim 1 or 2, wherein further contain 0.5~2.5 mass % of (E) fragrance.

7. it is a kind of as (A) in dentifrice composition, (B) ingredient and ameliorative way that foam caused by using drips, feature exist In, the viscosity of the 5W/V% aqueous solution in 25 DEG C for being mixed with (A) and being measured by Brookfield viscometer is 10mPas or more, and And to be that 800mPas is below high polymerize poly- second two to the viscosity of 2W/V% aqueous solution at measured by the viscosimeter 25 DEG C It is by quality ratio 0.05~5 with (C) ingredient/(D) ingredient in the dentifrice composition of alcohol and (B) alkyl sulfate Range mixes (C) amphoteric surfactant and (D) nonionic surface active agent,

(A) combined amount of ingredient is 0.05~0.5 mass %,

(D) ingredient is Crodaret.

8. as claimed in claim 7 as (A) in dentifrice composition, (B) ingredient and improvement that foam caused by using drips Method, wherein mixing 1~3.5 mass % of (B) ingredient, 0.05~1 mass % of (C) ingredient, 0.1~3 mass % of (D) ingredient.

9. as claimed in claim 7 or 8 as (A) in dentifrice composition, (B) ingredient and what foam caused by using dripped change Kind method, wherein further mixing 0.5~2.5 mass % of (E) fragrance.