CN105999174A

CN105999174A - Traditional Chinese medicine for treating diabetes and preparation method thereof

Info

Publication number: CN105999174A
Application number: CN201610522743.4A
Authority: CN
Inventors: 侯添有
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-07-06
Filing date: 2016-07-06
Publication date: 2016-10-12

Abstract

The invention discloses a traditional Chinese medicine for treating diabetes and a preparation method thereof. The traditional Chinese medicine is prepared from, by weight, 5-12 parts of fresh ginger, 10-15 parts of raw walnut kernels, 15-25 parts of cortex phellodendri, 15-20 parts of fructus mume, 10-15 parts of radix notoginseng powder, 7-10 parts of semen cassia and 2-7 parts of herba lysimachiae. The preparation method comprises the steps that the fresh ginger and the raw walnut kernels are stir-fried on a strong fire to be slightly yellow, cooled, ground and sieved to obtain fine powder; radix notoginseng, semen cassia and herba lysimachiae are washed clean, soaked in an ethanol solution and extracted under heating, filtration is conducted to obtain filtrate and filter residues, and the filtrate is concentrated into an extract; cortex phellodendri and fructus mume are washed clean and soaked together with the filter residues by adding water, extraction by decocting and filtration are conducted, and the filtrate is concentrated into paste; the fine powder, the extract and the paste are mixed and then prepared into granules, and then the traditional Chinese medicine is obtained. The traditional Chinese medicine preparation is appropriate in compatibility, has the dual effects of treating and conditioning, has the very good treatment effects on diseases of diabetes patients, has the advantages of being easy and convenient to prepare, wide in medicinal source, capable of rapidly achieving the treatment effects, thorough in treatment and low in cost and can be widely applied and popularized in clinical practice.

Description

A kind of Chinese medicine treating diabetes and preparation method thereof

Technical field

The present invention relates to technical field of Chinese medicines, a kind of Chinese medicine treating diabetes and preparation method thereof.

Background technology

Diabetes (diabetes) are that the glucose in a kind of blood easily piles up too much disease, it is by inherited genetic factors, immunologic function disorder, microorganism infection and toxin thereof, free radical toxin, the various virulence factor of Nervous and Mental Factors etc. acts on body and causes hypoinsulinism, insulin resistant (InsulinResistance, etc. IR) sugar caused, protein, fat, a series of metabolism disorder syndrome such as water and electrolyte, clinically with hyperglycemia as main feature, model case may occur in which polyuria, polydipsia, polyphagia, the performance such as become thin, i.e. " three-many-one-little " symptom.

In the most clinical hypoglycemic medicine used, various Western medicine have certain limitation and the most serious untoward reaction, and as caused hypoglycemia, lactic acidosis etc., and Chinese medicine lacks the antihypelipidemic preparation that curative effect affirmative, clinician and patient the most easily receive.Going back neither one medicine so far and can thoroughly cure diabetes, Western medicine the most simply can control blood glucose, and by contrast, Chinese medicine has the advantage of himself, and has good development prospect.It is believed that, the blood sugar lowering mechanism of Chinese medicine is combined relevant with its receptor to the immunologic function of regulation body, raising insulin, and strengthens cells secrete insulin, and this may treat diabetes for Chinese medicine by raising immunity of organisms and open up a new way.

Summary of the invention

It is an object of the invention to provide a kind of determined curative effect, Chinese medicine for the treatment of diabetes that side effect is little and preparation method thereof.

For achieving the above object, the present invention provides following technical scheme:

A kind of Chinese medicine treating diabetes, in parts by weight, composed of the following components: Rhizoma Zingiberis Recens 5-12 part, raw walnut core 10-15 part, Cortex Phellodendri 15-25 part, Fructus Mume 15-20 part, Radix Notoginseng 10-15 part, Semen Cassiae 7-10 part, Herba Lysimachiae 2-7 part.

As the further scheme of the present invention: in parts by weight, composed of the following components: Rhizoma Zingiberis Recens 8-9 part, raw walnut core 11-14 part, Cortex Phellodendri 18-22 part, Fructus Mume 16-19 part, Radix Notoginseng 11-14 part, Semen Cassiae 8-9 part, Herba Lysimachiae 4-5 part.

As the further scheme of the present invention: in parts by weight, composed of the following components: 9 parts of Rhizoma Zingiberis Recens, raw walnut core 13 parts, Cortex Phellodendri 20 parts, Fructus Mume 18 parts, Radix Notoginseng 13 parts, Semen Cassiae 9 parts, Herba Lysimachiae 5 parts.

The preparation method of the Chinese medicine of described treatment diabetes, comprises the following steps:

(1) Rhizoma Zingiberis Recens and raw walnut core being put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 600 mesh sieves, obtains fine powder, standby；

(2) by Radix Notoginseng, Semen Cassiae and Herba Lysimachiae are cleaned, pulverize with super micron mill, the ethanol solution that volumetric concentration is 40% of the 4-6 times amount immersing its quality soaks 30min, being separately immersed in volumetric concentration subsequently is 55%, 75%, 85% and 100% ethanol carries out gradient rotary evaporation eluting, then low-temperature reduced-pressure extracts 1-2h, temperature 30 DEG C-36 DEG C, pressure 0.7-0.9MPa, reclaim ethanol, with aperture in 2000 μm, molecular cut off obtains filtrate and filtering residue at the membrane filtration of 1000KDa, gained filtrate being concentrated is that at 60 DEG C, relative density is the extractum of 1.16-1.17, standby；

(3) Cortex Phellodendri and Fructus Mume are cleaned, after the water of the 6-8 times amount adding its quality sum together with the filtering residue in step (2) soaks 1-2h, boiled with intense fire, slow fire boiling 3-4h, filters, obtains the first filtrate and the first filtering residue；Then the first filtering residue is added again in the water of 5-6 times amount of its quality, boiled with intense fire, slow fire boiling 2-3h, filters, obtains the second filtrate and the second filtering residue；Finally the second filtering residue is added in the water of 4-5 times amount of its quality, boiled with intense fire, slow fire boiling 1-2h, filters, obtains the 3rd filtrate and the 3rd filtering residue；Merging the first filtrate, the second filtrate and the 3rd filtrate, filter, at concentrating under reduced pressure is 60 DEG C, relative density is the thick paste of 1.20-1.21, standby；

(4) fine powder obtained by above-mentioned steps (1)-(3), extractum and thick paste are mixed, and through Co60 sterilizing, make granule, be the Chinese medicine of described treatment diabetes.

The instructions of taking of the Chinese medicine of described treatment diabetes: every day twice, early, evening each the most once, warm boiled water half an hour after meal, each take the dosage being equivalent to 30g crude drug amount.Within 15 days, it is a course for the treatment of, takes effect 3-5 the course for the treatment of.

Compared with prior art, the invention has the beneficial effects as follows:

In Chinese medicine of the present invention, Rhizoma Zingiberis Recens relieving exterior syndrome and dispelling cold, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing, raw walnut core is warm in nature, sweet in the mouth, stomach invigorating, enrich blood, lung moistening, repose, Cortex Phellodendri heat-clearing and toxic substances removing, heat clearing and damp drying, Fructus Mume is astringed the lung, astringing intestine to stop diarrhea, promote the production of body fluid, the hemostasis of Radix Notoginseng dissipating blood stasis, subduing swelling and relieving pain, Semen Cassiae clearing away heat to improve acuity of vision, loosening bowel to relieve constipation, all medicine synergism, play strengthening vital QI to eliminate pathogenic factors, tranquilizing by nourishing the heart, effect of coordination internal organs negative and positive altogether, for the treatment of diabetes, there is the advantage that determined curative effect, side effect are little, easy to use, and preparation technology of the present invention is simple, it is easy to industrialized production.

Detailed description of the invention

Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is only a part of embodiment of the present invention rather than whole embodiments.Based on the embodiment in the present invention, the every other embodiment that those of ordinary skill in the art are obtained under not making creative work premise, broadly fall into the scope of protection of the invention.

Embodiment 1

A kind of Chinese medicine treating diabetes, in parts by weight, composed of the following components: 5 parts of Rhizoma Zingiberis Recens, raw walnut core 10 parts, Cortex Phellodendri 15 parts, Fructus Mume 15 parts, Radix Notoginseng 10 parts, Semen Cassiae 7 parts, Herba Lysimachiae 2 parts.

(2) Radix Notoginseng, Semen Cassiae and Herba Lysimachiae are cleaned, pulverize with super micron mill, the ethanol solution that volumetric concentration is 40% of 4 times amount immersing its quality soaks 30min, being separately immersed in volumetric concentration subsequently is to carry out gradient rotary evaporation eluting in 55%, 75%, 85% and 100% ethanol, then low-temperature reduced-pressure extracts 1h, temperature 30 DEG C, pressure 0.7MPa, reclaim ethanol, with aperture in 2000 μm, molecular cut off obtains filtrate and filtering residue at the membrane filtration of 1000KDa, and gained filtrate being concentrated is that at 60 DEG C, relative density is the extractum of 1.16, standby；

(3) Cortex Phellodendri and Fructus Mume are cleaned, after the water of 6 times amount adding its quality sum together with the filtering residue in step (2) soaks 1h, boiled with intense fire, slow fire boiling 3h, filters, obtains the first filtrate and the first filtering residue；Then the first filtering residue is added again in the water of 5 times amount of its quality, boiled with intense fire, slow fire boiling 2h, filters, obtains the second filtrate and the second filtering residue；Finally the second filtering residue is added in the water of 4 times amount of its quality, boiled with intense fire, slow fire boiling 1h, filters, obtains the 3rd filtrate and the 3rd filtering residue；Merging the first filtrate, the second filtrate and the 3rd filtrate, filter, at concentrating under reduced pressure is 60 DEG C, relative density is the thick paste of 1.20, standby；

Embodiment 2

A kind of Chinese medicine treating diabetes, in parts by weight, composed of the following components: 8 parts of Rhizoma Zingiberis Recens, raw walnut core 11 parts, Cortex Phellodendri 18 parts, Fructus Mume 16 parts, Radix Notoginseng 11 parts, Semen Cassiae 8 parts, Herba Lysimachiae 4 parts.

Embodiment 3

A kind of Chinese medicine treating diabetes, in parts by weight, composed of the following components: 9 parts of Rhizoma Zingiberis Recens, raw walnut core 13 parts, Cortex Phellodendri 20 parts, Fructus Mume 18 parts, Radix Notoginseng 13 parts, Semen Cassiae 9 parts, Herba Lysimachiae 5 parts.

(2) Radix Notoginseng, Semen Cassiae and Herba Lysimachiae are cleaned, pulverize with super micron mill, the ethanol solution that volumetric concentration is 40% of 5 times amount immersing its quality soaks 30min, being separately immersed in volumetric concentration subsequently is to carry out gradient rotary evaporation eluting in 55%, 75%, 85% and 100% ethanol, then low-temperature reduced-pressure extracts 1.5h, temperature 33 DEG C, pressure 0.8MPa, reclaim ethanol, with aperture in 2000 μm, molecular cut off obtains filtrate and filtering residue at the membrane filtration of 1000KDa, and gained filtrate being concentrated is that at 60 DEG C, relative density is the extractum of 1.17, standby；

(3) Cortex Phellodendri and Fructus Mume are cleaned, after the water of 7 times amount adding its quality sum together with the filtering residue in step (2) soaks 1.5h, boiled with intense fire, slow fire boiling 3.5h, filters, obtains the first filtrate and the first filtering residue；Then the first filtering residue is added again in the water of 5.5 times amount of its quality, boiled with intense fire, slow fire boiling 2.5h, filters, obtains the second filtrate and the second filtering residue；Finally the second filtering residue is added in the water of 4.5 times amount of its quality, boiled with intense fire, slow fire boiling 1.5h, filters, obtains the 3rd filtrate and the 3rd filtering residue；Merging the first filtrate, the second filtrate and the 3rd filtrate, filter, at concentrating under reduced pressure is 60 DEG C, relative density is the thick paste of 1.21, standby；

Embodiment 4

A kind of Chinese medicine treating diabetes, in parts by weight, composed of the following components: 9 parts of Rhizoma Zingiberis Recens, raw walnut core 14 parts, Cortex Phellodendri 22 parts, Fructus Mume 19 parts, Radix Notoginseng 14 parts, Semen Cassiae 9 parts, Herba Lysimachiae 5 parts.

(2) Radix Notoginseng, Semen Cassiae and Herba Lysimachiae are cleaned, pulverize with super micron mill, the ethanol solution that volumetric concentration is 40% of 5 times amount immersing its quality soaks 30min, being separately immersed in volumetric concentration subsequently is to carry out gradient rotary evaporation eluting in 55%, 75%, 85% and 100% ethanol, then low-temperature reduced-pressure extracts 2h, temperature 36 DEG C, pressure 0.9MPa, reclaim ethanol, with aperture in 2000 μm, molecular cut off obtains filtrate and filtering residue at the membrane filtration of 1000KDa, and gained filtrate being concentrated is that at 60 DEG C, relative density is the extractum of 1.17, standby；

(3) Cortex Phellodendri and Fructus Mume are cleaned, after the water of 7 times amount adding its quality sum together with the filtering residue in step (2) soaks 1h, boiled with intense fire, slow fire boiling 3h, filters, obtains the first filtrate and the first filtering residue；Then the first filtering residue is added again in the water of 6 times amount of its quality, boiled with intense fire, slow fire boiling 3h, filters, obtains the second filtrate and the second filtering residue；Finally the second filtering residue is added in the water of 4 times amount of its quality, boiled with intense fire, slow fire boiling 1.5h, filters, obtains the 3rd filtrate and the 3rd filtering residue；Merging the first filtrate, the second filtrate and the 3rd filtrate, filter, at concentrating under reduced pressure is 60 DEG C, relative density is the thick paste of 1.21, standby；

Embodiment 5

A kind of Chinese medicine treating diabetes, in parts by weight, composed of the following components: 12 parts of Rhizoma Zingiberis Recens, raw walnut core 15 parts, Cortex Phellodendri 25 parts, Fructus Mume 20 parts, Radix Notoginseng 15 parts, Semen Cassiae 10 parts, Herba Lysimachiae 7 parts.

(2) Radix Notoginseng, Semen Cassiae and Herba Lysimachiae are cleaned, pulverize with super micron mill, the ethanol solution that volumetric concentration is 40% of 6 times amount immersing its quality soaks 30min, being separately immersed in volumetric concentration subsequently is to carry out gradient rotary evaporation eluting in 55%, 75%, 85% and 100% ethanol, then low-temperature reduced-pressure extracts 2h, temperature 36 DEG C, pressure 0.9MPa, reclaim ethanol, with aperture in 2000 μm, molecular cut off obtains filtrate and filtering residue at the membrane filtration of 1000KDa, and gained filtrate being concentrated is that at 60 DEG C, relative density is the extractum of 1.17, standby；

(3) Cortex Phellodendri and Fructus Mume are cleaned, after the water of 8 times amount adding its quality sum together with the filtering residue in step (2) soaks 2h, boiled with intense fire, slow fire boiling 4h, filters, obtains the first filtrate and the first filtering residue；Then the first filtering residue is added again in the water of 6 times amount of its quality, boiled with intense fire, slow fire boiling 3h, filters, obtains the second filtrate and the second filtering residue；Finally the second filtering residue is added in the water of 5 times amount of its quality, boiled with intense fire, slow fire boiling 2h, filters, obtains the 3rd filtrate and the 3rd filtering residue；Merging the first filtrate, the second filtrate and the 3rd filtrate, filter, at concentrating under reduced pressure is 60 DEG C, relative density is the thick paste of 1.21, standby；

Drug toxicology is tested

1, acute toxicity test

With the prepared granule of the embodiment of the present invention 3 for test, using gastric infusion mode, successive administration 3 times in 24h, every minor tick 4h, be administered 80g crude drug amount every time, accumulation medicine total amount reaches 240g crude drug/kg, is equivalent to 80 times of people's quantity.After administration in 7d, mice is movable, take food, drain all normally, well-grown, and hair color light, its average body weight average increases with the prolongation of experimental period.Post mortem every mice at 8d, the perusal heart, liver, spleen, lung, kidney, brain, thymus, stomach, intestinal etc. all do not find color and paramophia, fail to measure median lethal dose(LD 50) (LD₅₀).Result shows: Chinese medicine of the present invention is without acute toxic reaction.

2, long term toxicity test

With the prepared granule of the embodiment of the present invention 3 for test, use gastric infusion mode, Chinese medicine of the present invention is divided into low dosage, middle dosage, high dose three groups, the drug dose of each group is respectively 30,60,120g crude drug/kg/d, be equivalent to the 10 of clinical dosage, 20,40 times.After gastric infusion 24 weeks, Chinese medicine of the present invention on the general status of animal, hematological indices, blood parameters all without significantly impact, the most no abnormal pathological change of Systematic anatomy, organ coefficient and histopathological examination.Drug withdrawal also has no substantially change for 2 weeks.Result shows: Chinese medicine of the present invention, in long term toxicity test, does not finds that overt toxicity reaction and delayed toxicity react.Visible, Chinese medicine non-toxic reaction of the present invention, long-term prescription is safe and reliable.

Clinical data

1, case selection

Select the diabetes 400 example clinical observation made a definite diagnosis, the maleest 203 examples, women 197 example, age 25-65 year, 39.4 years old mean age.This 400 example patient being randomly divided into treatment 1-5 group, comparison 1-3 group totally eight groups, often organizes 50 examples, each group course of disease of case, degrees of symptoms are basically identical, without significant difference, have comparability.

2, diagnostic criteria

By the diagnostic criteria that " internal medicine " the 8th edition is diabetes.

3, Therapeutic Method

Treatment 1-5 group: take granule prepared by embodiment of the present invention 1-5 respectively, every day twice, early, evening each the most once, warm boiled water half an hour after meal, each take the dosage being equivalent to 30g crude drug amount.It within 15 days, it is a course for the treatment of.

Compareing 1 group: glimepiride capsules (Sichuan Pu Du pharmaceutical factory) 2mg, each 1, every day 1 time, 15 days is 1 course for the treatment of.

Compareing 2 groups: the granule taken, contain only Rhizoma Zingiberis Recens, Radix Notoginseng both components, remaining is identical with embodiment 3.Every day twice, early, evening each the most once, warm boiled water half an hour after meal, each take the dosage being equivalent to 30g crude drug amount.It within 15 days, it is a course for the treatment of.

Compareing 3 groups: the granule taken, contain only this kind of component of Rhizoma Zingiberis Recens, remaining is identical with embodiment 3.Every day twice, early, evening each the most once, warm boiled water half an hour after meal, each take the dosage being equivalent to 30g crude drug amount.It within 15 days, it is a course for the treatment of.

4, the standard of curative effect evaluation

Therapeutic evaluation is carried out with reference to " Chinese medical disease Standardization of diagnosis and curative effect ".

Cure: transference cure, how subnormal lab testing is；

Take a turn for the better: cardinal symptom and relevant lab testing have improvement；

Do not heal: symptom and lab testing are unchanged.

5, therapeutic outcome

The comparitive study that table 1 is respectively organized

Project	Case load	Cure number	Good revolution	Several	Cure rate	Total effective rate
							Treat 1 group	50	38	7	5	76%	90%
Treat 2 groups	50	42	4	4	84%	92%
							Treat 3 groups	50	46	3	1	92%	98%
Treat 4 groups	50	45	4	1	90%	98%
							Treat 5 groups	50	45	2	3	90%	94%
Compare 1 group	50	17	3	30	34%	40%
							Compare 2 groups	50	8	4	38	16%	24%
Compare 3 groups	50	0	5	45	0%	10%

After the treatment of month, the curative effect of each group is as shown in table 1: the cure rate for the treatment of group is 76-92%, and total effective rate is up to more than 90%；Compared with matched group, the cure rate for the treatment of group and total effective rate are all far superior to matched group, difference statistically significant (P ＜ 0.05), illustrate that in Chinese medicine of the present invention, each component has obvious synergistic function.According to data in above table, Chinese medicine of the present invention have rapid-action, effective percentage is high, determined curative effect, safety is high, have no side effect, the simple advantage of medication；Meanwhile, the most no abnormal according to clinical observation, routine test and Function detection, and follow up a case by regular visits to 1 year, result is added up, treatment group is without recurrence, and compares 1 group 17 and cure patient, recurs 12 examples, relapse rate 70.6%, compare 2 group of 8 example and cure patient, recur 3 examples, relapse rate 42.9%.

6, model case

Case 1: grandson, female, 58 years old, it is diagnosed as " type ii diabetes ", xerostomia, thirsty, polydipsia, polyuria, becomes thin, and with blurred vision.After taking 1 course for the treatment of of granule of the embodiment of the present invention 3 preparation, symptom makes moderate progress；After continuing to take 1 course for the treatment of, transference cure, how subnormal lab testing is.Follow up a case by regular visits to 1 year, do not recur.

Case 2: slowly certain, man, 41 years old, suffer from severe diabetes mellitus, and obscure with severe visual.After taking 2 courses for the treatment of of granule of the embodiment of the present invention 3 preparation, main transference cure, how subnormal lab testing is.Follow up a case by regular visits to 1 year, do not recur.

Case 3: money, man, 27 years old, fatigue and asthenia, breathe hard lazy speech, xerostomia, soreness of the waist and knees, nocturia, once the Drug therapy such as glimepiride therapy capsule, without alleviation, was diabetes after diagnosing.After taking 1 course for the treatment of of granule of the embodiment of the present invention 3 preparation, cardinal symptom and relevant lab testing have improvement.Follow up a case by regular visits to 1 year, do not recur.

It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, and without departing from the spirit or essential characteristics of the present invention, it is possible to realize the present invention in other specific forms.Therefore, no matter from the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is limited by claims rather than described above, it is intended that all changes fallen in the implication of equivalency and scope of claim included in the present invention.

In addition, it is to be understood that, although this specification is been described by according to embodiment, but the most each embodiment only comprises an independent technical scheme, this narrating mode of description is only for clarity sake, description should can also be formed, through appropriately combined, other embodiments that it will be appreciated by those skilled in the art that as an entirety, the technical scheme in each embodiment by those skilled in the art.

Claims

1. the Chinese medicine treating diabetes, it is characterised in that in parts by weight, composed of the following components: Rhizoma Zingiberis Recens 5-12 part, raw walnut core 10-15 part, Cortex Phellodendri 15-25 part, Fructus Mume 15-20 part, Radix Notoginseng 10-15 part, Semen Cassiae 7-10 part, Herba Lysimachiae 2-7 part.

The Chinese medicine for the treatment of diabetes the most according to claim 1, it is characterized in that, in parts by weight, composed of the following components: Rhizoma Zingiberis Recens 8-9 part, raw walnut core 11-14 part, Cortex Phellodendri 18-22 part, Fructus Mume 16-19 part, Radix Notoginseng 11-14 part, Semen Cassiae 8-9 part, Herba Lysimachiae 4-5 part.

The Chinese medicine for the treatment of diabetes the most according to claim 1, it is characterised in that in parts by weight, composed of the following components: 9 parts of Rhizoma Zingiberis Recens, raw walnut core 13 parts, Cortex Phellodendri 20 parts, Fructus Mume 18 parts, Radix Notoginseng 13 parts, Semen Cassiae 9 parts, Herba Lysimachiae 5 parts.

4. according to the preparation method of the Chinese medicine of the arbitrary described treatment diabetes of claim 1-3, it is characterised in that comprise the following steps: