CN105999152A - Traditional Chinese medicine for treating gastric ulcer and preparation method thereof - Google Patents
Traditional Chinese medicine for treating gastric ulcer and preparation method thereof Download PDFInfo
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Classifications
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- A61K2236/30—Extraction of the material
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- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses a traditional Chinese medicine for treating gastric ulcer and a preparation method thereof. The traditional Chinese medicine comprises, by weight, 10 to 20 parts of ginger, 25 to 32 parts of shaddock peel, 8 to 12 parts of garlic, 5 to 10 parts of Folium Isatidis, 7 to 10 parts of licorice root and 5 to 12 parts of dandelion. The preparation method comprises the following steps: stir-frying the ginger on a strong fire until the ginger is slightly yellow, cooling the ginger in the air and then carrying out grinding and sieving so as to obtain fine powder; cleaning the garlic, dandelion and licorice root, soaking the cleaned garlic, dandelion and licorice root in an ethanol solution, carrying out heating and extraction, then carrying out filtering so as to obtain a filtrate and filter residues and concentrating the filtrate so as to obtain extract; cleaning the shaddock peel and Folium Isatidis, soaking the cleaned shaddock peel and Folium Isatidis and the filter residues in water, carrying out decoction and extraction, then carrying out filtering and concentrating the obtained filtrate so as to obtain stiff paste; and mixing the fine powder, extract and stiff paste and preparing granules so as to obtain the traditional Chinese medicine for treating gastric ulcer. The raw materials of the traditional Chinese medicine are in good compatibility; and the traditional Chinese medicine has the double effects of treatment and conditioning, exerts good curative effect in treatment of patients with gastric ulcer, has the advantages of simple preparation, wide sources of the raw materials, fast action, thorough treatment and low cost, and can be promoted and applied in clinical practice.
Description
Technical field
The present invention relates to technical field of Chinese medicines, a kind of Chinese medicine treating gastric ulcer and preparation method thereof.
Background technology
In recent years, along with improving constantly of people's living standard, there is the biggest change in the life style of people, and incident is that the sickness rate of gastroenteropathy and prevalence are all in obvious ascendant trend.Gastric ulcer is the commonly encountered diseases in gastrointestinal system disease, frequently-occurring disease, and this disease is easy to merging and gastrorrhagia occurs, mainly show as stomachache, flatulence, suffer from diarrhoea, have blood in stool, the symptom such as hematemesis, in Chinese medicine, belong to the category such as " gastric abscess ", " feeling of fullness ".In terms of etiology and pathogenesis, the generation of the gastroenteropathy such as gastric ulcer, gastrorrhagia, think mainly relevant with the factor such as weakness of the spleen and stomach, disorder of emotion, injury due to diet, being invaded by exogenous pathogen more, wherein weakness of the spleen and stomach is pathologic basis, the many simulataneous insufficiency and excessive of characteristic of disease.Chinese medicine is thought: overstrain, injury due to diet, prolonged illness, and ferritic does not wait and all can undermine spleen sun, causes weakness of the spleen and stomach.Clinically, the gastroenteropathy such as the gastric ulcer that causes Deficiency and coldness of spleen and stomach, gastrorrhagia, doctor trained in Western medicine mainly uses the Therapeutic Method such as acid suppression, pain relieving, antidiarrheal, and Chinese medicine then uses warming stomach for dispelling cold, eliminating stasis to stop pain, warming spleen and stopping diarrha method.The curative effect that current Chinese medicine treats this disease has been found to, and uses Chinese medicinal material extract to study further, more can give full play to the advantage of Chinese medicine.
Summary of the invention
It is an object of the invention to provide a kind of determined curative effect, Chinese medicine for the treatment of gastric ulcer that side effect is little and preparation method thereof.
For achieving the above object, the present invention provides following technical scheme:
A kind of Chinese medicine treating gastric ulcer, in parts by weight, composed of the following components: Rhizoma Zingiberis Recens 10-20 part, Pericarpium Citri grandis 25-32 part, Bulbus Allii 8-12 part, Folium Isatidis 5-10 part, Radix Glycyrrhizae 7-10 part, Herba Taraxaci 5-12 part.
As the further scheme of the present invention: in parts by weight, composed of the following components: Rhizoma Zingiberis Recens 13-17 part, Pericarpium Citri grandis 28-29 part, Bulbus Allii 9-11 part, Folium Isatidis 7-8 part, Radix Glycyrrhizae 8-9 part, Herba Taraxaci 7-10 part.
As the further scheme of the present invention: in parts by weight, composed of the following components: 15 parts of Rhizoma Zingiberis Recens, Pericarpium Citri grandis 29 parts, 10 parts of Bulbus Allii, Folium Isatidis 8 parts, 9 parts of Radix Glycyrrhizae, Herba Taraxaci 9 parts.
The preparation method of the Chinese medicine of described treatment gastric ulcer, comprises the following steps:
(1) Rhizoma Zingiberis Recens being put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 400 mesh sieves, obtains fine powder, standby；
(2) Bulbus Allii, Herba Taraxaci and Radix Glycyrrhizae are cleaned, pulverize, the ethanol solution that volumetric concentration is 40% of the 4-6 times amount immersing its quality soaks 1-2h, being separately immersed in volumetric concentration subsequently is to carry out gradient elution in 50%, 70%, 90% and 100% ethanol, then low-temperature reduced-pressure extracts 2-3h, temperature 32 DEG C-42 DEG C, pressure 0.6-0.8MPa, reclaim ethanol, with aperture in 2000 μm, molecular cut off obtains filtrate and filtering residue at the membrane filtration of 300KDa, and gained filtrate being concentrated is that at 60 DEG C, relative density is the extractum of 1.18-1.19, standby；
(3) Pericarpium Citri grandis and Folium Isatidis are cleaned, after the water of the 6-8 times amount adding its quality sum together with the filtering residue in step (2) soaks 1-2h, boiled with intense fire, slow fire boiling 3-4h, filters, obtains the first filtrate and the first filtering residue；Then the first filtering residue is added again in the water of 5-6 times amount of its quality, boiled with intense fire, slow fire boiling 2-3h, filters, obtains the second filtrate and the second filtering residue；Finally the second filtering residue is added in the water of 4-5 times amount of its quality, boiled with intense fire, slow fire boiling 1-2h, filters, obtains the 3rd filtrate and the 3rd filtering residue；Merging the first filtrate, the second filtrate and the 3rd filtrate, filter, at concentrating under reduced pressure is 60 DEG C, relative density is the thick paste of 1.21-1.22, standby；
(4) fine powder obtained by above-mentioned steps (1)-(3), extractum and thick paste are mixed, and through Co60 sterilizing, make granule, be the Chinese medicine of described treatment gastric ulcer.
The instructions of taking of the Chinese medicine of described treatment gastric ulcer: every day twice, early, evening each the most once, warm boiled water half an hour after meal, each take the dosage being equivalent to 50g crude drug amount.Within 15 days, it is a course for the treatment of, takes effect 3-5 the course for the treatment of.
Compared with prior art, the invention has the beneficial effects as follows:
In Chinese medicine of the present invention, Rhizoma Zingiberis Recens relieving exterior syndrome and dispelling cold, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing, Pericarpium Citri grandis reduces phlegm, helps digestion, the therapeutic method to keep the adverse QI flowing downwards, fast diaphragm, Bulbus Allii stomach invigorating, dysentery relieving, sterilization, anthelmintic, Folium Isatidis heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, Herba Taraxaci dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome, all medicine synergism, play effect of promoting the circulation of QI to relieve pain, tranquilizing by nourishing the heart, promoting blood circulation and hemostasis altogether, for the treatment of gastric ulcer, there is the advantage that determined curative effect, side effect are little, easy to use, and preparation technology of the present invention is simple, it is easy to industrialized production.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is only a part of embodiment of the present invention rather than whole embodiments.Based on the embodiment in the present invention, the every other embodiment that those of ordinary skill in the art are obtained under not making creative work premise, broadly fall into the scope of protection of the invention.
Embodiment 1
A kind of Chinese medicine treating gastric ulcer, in parts by weight, composed of the following components: 10 parts of Rhizoma Zingiberis Recens, Pericarpium Citri grandis 25 parts, 8 parts of Bulbus Allii, Folium Isatidis 5 parts, 7 parts of Radix Glycyrrhizae, Herba Taraxaci 5 parts.
The preparation method of the Chinese medicine of described treatment gastric ulcer, comprises the following steps:
(1) Rhizoma Zingiberis Recens being put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 400 mesh sieves, obtains fine powder, standby；
(2) Bulbus Allii, Herba Taraxaci and Radix Glycyrrhizae are cleaned, pulverize, the ethanol solution that volumetric concentration is 40% of 4 times amount immersing its quality soaks 1h, being separately immersed in volumetric concentration subsequently is to carry out gradient elution in 50%, 70%, 90% and 100% ethanol, then low-temperature reduced-pressure extracts 2h, temperature 32 DEG C, pressure 0.6MPa, reclaim ethanol, with aperture in 2000 μm, molecular cut off obtains filtrate and filtering residue at the membrane filtration of 300KDa, and gained filtrate being concentrated is that at 60 DEG C, relative density is the extractum of 1.18, standby；
(3) Pericarpium Citri grandis and Folium Isatidis are cleaned, after the water of 6 times amount adding its quality sum together with the filtering residue in step (2) soaks 1h, boiled with intense fire, slow fire boiling 3h, filters, obtains the first filtrate and the first filtering residue；Then the first filtering residue is added again in the water of 5 times amount of its quality, boiled with intense fire, slow fire boiling 2h, filters, obtains the second filtrate and the second filtering residue；Finally the second filtering residue is added in the water of 4 times amount of its quality, boiled with intense fire, slow fire boiling 1h, filters, obtains the 3rd filtrate and the 3rd filtering residue；Merging the first filtrate, the second filtrate and the 3rd filtrate, filter, at concentrating under reduced pressure is 60 DEG C, relative density is the thick paste of 1.21, standby；
(4) fine powder obtained by above-mentioned steps (1)-(3), extractum and thick paste are mixed, and through Co60 sterilizing, make granule, be the Chinese medicine of described treatment gastric ulcer.
Embodiment 2
A kind of Chinese medicine treating gastric ulcer, in parts by weight, composed of the following components: 13 parts of Rhizoma Zingiberis Recens, Pericarpium Citri grandis 28 parts, 9 parts of Bulbus Allii, Folium Isatidis 7 parts, 8 parts of Radix Glycyrrhizae, Herba Taraxaci 7 parts.
The preparation method of the Chinese medicine of described treatment gastric ulcer, comprises the following steps:
(1) Rhizoma Zingiberis Recens being put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 400 mesh sieves, obtains fine powder, standby；
(2) Bulbus Allii, Herba Taraxaci and Radix Glycyrrhizae are cleaned, pulverize, the ethanol solution that volumetric concentration is 40% of 4 times amount immersing its quality soaks 1h, being separately immersed in volumetric concentration subsequently is to carry out gradient elution in 50%, 70%, 90% and 100% ethanol, then low-temperature reduced-pressure extracts 2h, temperature 32 DEG C, pressure 0.6MPa, reclaim ethanol, with aperture in 2000 μm, molecular cut off obtains filtrate and filtering residue at the membrane filtration of 300KDa, and gained filtrate being concentrated is that at 60 DEG C, relative density is the extractum of 1.18, standby；
(3) Pericarpium Citri grandis and Folium Isatidis are cleaned, after the water of 6 times amount adding its quality sum together with the filtering residue in step (2) soaks 1h, boiled with intense fire, slow fire boiling 3h, filters, obtains the first filtrate and the first filtering residue；Then the first filtering residue is added again in the water of 5 times amount of its quality, boiled with intense fire, slow fire boiling 2h, filters, obtains the second filtrate and the second filtering residue；Finally the second filtering residue is added in the water of 4 times amount of its quality, boiled with intense fire, slow fire boiling 1h, filters, obtains the 3rd filtrate and the 3rd filtering residue；Merging the first filtrate, the second filtrate and the 3rd filtrate, filter, at concentrating under reduced pressure is 60 DEG C, relative density is the thick paste of 1.21, standby；
(4) fine powder obtained by above-mentioned steps (1)-(3), extractum and thick paste are mixed, and through Co60 sterilizing, make granule, be the Chinese medicine of described treatment gastric ulcer.
Embodiment 3
A kind of Chinese medicine treating gastric ulcer, in parts by weight, composed of the following components: 15 parts of Rhizoma Zingiberis Recens, Pericarpium Citri grandis 29 parts, 10 parts of Bulbus Allii, Folium Isatidis 8 parts, 9 parts of Radix Glycyrrhizae, Herba Taraxaci 9 parts.
The preparation method of the Chinese medicine of described treatment gastric ulcer, comprises the following steps:
(1) Rhizoma Zingiberis Recens being put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 400 mesh sieves, obtains fine powder, standby；
(2) Bulbus Allii, Herba Taraxaci and Radix Glycyrrhizae are cleaned, pulverize, the ethanol solution that volumetric concentration is 40% of 5 times amount immersing its quality soaks 1.5h, being separately immersed in volumetric concentration subsequently is to carry out gradient elution in 50%, 70%, 90% and 100% ethanol, then low-temperature reduced-pressure extracts 2.5h, temperature 37 DEG C, pressure 0.7MPa, reclaim ethanol, with aperture in 2000 μm, molecular cut off obtains filtrate and filtering residue at the membrane filtration of 300KDa, and gained filtrate being concentrated is that at 60 DEG C, relative density is the extractum of 1.18, standby；
(3) Pericarpium Citri grandis and Folium Isatidis are cleaned, after the water of 7 times amount adding its quality sum together with the filtering residue in step (2) soaks 1.5h, boiled with intense fire, slow fire boiling 3.5h, filters, obtains the first filtrate and the first filtering residue；Then the first filtering residue is added again in the water of 5.5 times amount of its quality, boiled with intense fire, slow fire boiling 2.5h, filters, obtains the second filtrate and the second filtering residue；Finally the second filtering residue is added in the water of 4.5 times amount of its quality, boiled with intense fire, slow fire boiling 1.5h, filters, obtains the 3rd filtrate and the 3rd filtering residue；Merging the first filtrate, the second filtrate and the 3rd filtrate, filter, at concentrating under reduced pressure is 60 DEG C, relative density is the thick paste of 1.21, standby；
(4) fine powder obtained by above-mentioned steps (1)-(3), extractum and thick paste are mixed, and through Co60 sterilizing, make granule, be the Chinese medicine of described treatment gastric ulcer.
Embodiment 4
A kind of Chinese medicine treating gastric ulcer, in parts by weight, composed of the following components: 17 parts of Rhizoma Zingiberis Recens, Pericarpium Citri grandis 29 parts, 11 parts of Bulbus Allii, Folium Isatidis 8 parts, 9 parts of Radix Glycyrrhizae, Herba Taraxaci 10 parts.
The preparation method of the Chinese medicine of described treatment gastric ulcer, comprises the following steps:
(1) Rhizoma Zingiberis Recens being put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 400 mesh sieves, obtains fine powder, standby；
(2) Bulbus Allii, Herba Taraxaci and Radix Glycyrrhizae are cleaned, pulverize, the ethanol solution that volumetric concentration is 40% of 5 times amount immersing its quality soaks 1.5h, being separately immersed in volumetric concentration subsequently is to carry out gradient elution in 50%, 70%, 90% and 100% ethanol, then low-temperature reduced-pressure extracts 2.5h, temperature 37 DEG C, pressure 0.7MPa, reclaim ethanol, with aperture in 2000 μm, molecular cut off obtains filtrate and filtering residue at the membrane filtration of 300KDa, and gained filtrate being concentrated is that at 60 DEG C, relative density is the extractum of 1.18, standby；
(3) Pericarpium Citri grandis and Folium Isatidis are cleaned, after the water of 7 times amount adding its quality sum together with the filtering residue in step (2) soaks 1.5h, boiled with intense fire, slow fire boiling 3.5h, filters, obtains the first filtrate and the first filtering residue；Then the first filtering residue is added again in the water of 5.5 times amount of its quality, boiled with intense fire, slow fire boiling 2.5h, filters, obtains the second filtrate and the second filtering residue；Finally the second filtering residue is added in the water of 4.5 times amount of its quality, boiled with intense fire, slow fire boiling 1.5h, filters, obtains the 3rd filtrate and the 3rd filtering residue；Merging the first filtrate, the second filtrate and the 3rd filtrate, filter, at concentrating under reduced pressure is 60 DEG C, relative density is the thick paste of 1.21, standby；
(4) fine powder obtained by above-mentioned steps (1)-(3), extractum and thick paste are mixed, and through Co60 sterilizing, make granule, be the Chinese medicine of described treatment gastric ulcer.
Embodiment 5
A kind of Chinese medicine treating gastric ulcer, in parts by weight, composed of the following components: 20 parts of Rhizoma Zingiberis Recens, Pericarpium Citri grandis 32 parts, 12 parts of Bulbus Allii, Folium Isatidis 10 parts, 10 parts of Radix Glycyrrhizae, Herba Taraxaci 12 parts.
The preparation method of the Chinese medicine of described treatment gastric ulcer, comprises the following steps:
(1) Rhizoma Zingiberis Recens being put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 400 mesh sieves, obtains fine powder, standby；
(2) Bulbus Allii, Herba Taraxaci and Radix Glycyrrhizae are cleaned, pulverize, the ethanol solution that volumetric concentration is 40% of 6 times amount immersing its quality soaks 2h, being separately immersed in volumetric concentration subsequently is to carry out gradient elution in 50%, 70%, 90% and 100% ethanol, then low-temperature reduced-pressure extracts 3h, temperature 42 DEG C, pressure 0.8MPa, reclaim ethanol, with aperture in 2000 μm, molecular cut off obtains filtrate and filtering residue at the membrane filtration of 300KDa, and gained filtrate being concentrated is that at 60 DEG C, relative density is the extractum of 1.19, standby；
(3) Pericarpium Citri grandis and Folium Isatidis are cleaned, after the water of 8 times amount adding its quality sum together with the filtering residue in step (2) soaks 2h, boiled with intense fire, slow fire boiling 4h, filters, obtains the first filtrate and the first filtering residue；Then the first filtering residue is added again in the water of 6 times amount of its quality, boiled with intense fire, slow fire boiling 3h, filters, obtains the second filtrate and the second filtering residue；Finally the second filtering residue is added in the water of 5 times amount of its quality, boiled with intense fire, slow fire boiling 2h, filters, obtains the 3rd filtrate and the 3rd filtering residue；Merging the first filtrate, the second filtrate and the 3rd filtrate, filter, at concentrating under reduced pressure is 60 DEG C, relative density is the thick paste of 1.22, standby；
(4) fine powder obtained by above-mentioned steps (1)-(3), extractum and thick paste are mixed, and through Co60 sterilizing, make granule, be the Chinese medicine of described treatment gastric ulcer.
Drug toxicology is tested
1, acute toxicity test
With the prepared granule of the embodiment of the present invention 3 for test, using gastric infusion mode, successive administration 3 times in 24h, every minor tick 4h, be administered 120g crude drug amount every time, accumulation medicine total amount reaches 480g crude drug/kg, is equivalent to 100 times of people's quantity.After administration in 7d, mice is movable, take food, drain all normally, well-grown, and hair color light, its average body weight average increases with the prolongation of experimental period.Post mortem every mice at 8d, the perusal heart, liver, spleen, lung, kidney, brain, thymus, stomach, intestinal etc. all do not find color and paramophia, fail to measure median lethal dose(LD 50) (LD50).Result shows: Chinese medicine of the present invention is without acute toxic reaction.
2, long term toxicity test
With the prepared granule of the embodiment of the present invention 3 for test, use gastric infusion mode, Chinese medicine of the present invention is divided into low dosage, middle dosage, high dose three groups, the drug dose of each group is respectively 40,80,160g crude drug/kg/d, be equivalent to the 10 of clinical dosage, 20,40 times.After gastric infusion 24 weeks, Chinese medicine of the present invention on the general status of animal, hematological indices, blood parameters all without significantly impact, the most no abnormal pathological change of Systematic anatomy, organ coefficient and histopathological examination.Drug withdrawal also has no substantially change for 2 weeks.Result shows: Chinese medicine of the present invention, in long term toxicity test, does not finds that overt toxicity reaction and delayed toxicity react.Visible, Chinese medicine non-toxic reaction of the present invention, long-term prescription is safe and reliable.
Clinical data
1, case selection
Select the gastric ulcer 400 example clinical observation made a definite diagnosis, the maleest 224 examples, women 176 example, age 25-65 year, 37.2 years old mean age.This 400 example infant being randomly divided into treatment 1-5 group, comparison 1-3 group totally eight groups, often organizes 50 examples, each group course of disease of case, degrees of symptoms are basically identical, without significant difference, have comparability.
2, diagnostic criteria
By the diagnostic criteria that " internal medicine " the 8th edition is gastric ulcer.
3, Therapeutic Method
Treatment 1-5 group: take granule prepared by embodiment of the present invention 1-5 respectively, every day twice, early, evening each the most once, warm boiled water half an hour after meal, each take the dosage being equivalent to 50g crude drug amount.Within 15 days, it is a course for the treatment of, takes effect 3-5 the course for the treatment of.
Compareing 1 group: magnesium omeprazole enteric coatel tablets (as long as AstraZeneca company limited) 0.01g, each 1, every day 1 time, 14 days is 1 course for the treatment of.
Compareing 2 groups: the granule taken, contain only Rhizoma Zingiberis Recens, Pericarpium Citri grandis, Folium Isatidis these three component, remaining is identical with embodiment 3.Every day twice, early, evening each the most once, warm boiled water half an hour after meal, each take the dosage being equivalent to 50g crude drug amount.Within 15 days, it is a course for the treatment of, takes effect 3-5 the course for the treatment of.
Compareing 3 groups: the granule taken, contain only this kind of component of Rhizoma Zingiberis Recens, remaining is identical with embodiment 3.Every day twice, early, evening each the most once, warm boiled water half an hour after meal, each take the dosage being equivalent to 50g crude drug amount.Within 15 days, it is a course for the treatment of, takes effect 3-5 the course for the treatment of.
4, the standard of curative effect evaluation
Therapeutic evaluation is carried out with reference to " Chinese medical disease Standardization of diagnosis and curative effect ".
Clinical cure: primary symptom, secondary disease all eliminate, fibergastroscopy ulcer healing of focus, pathological changes mucosa recovers normal；
Effective: primary symptom, secondary disease all eliminate, and ulcer focus heals substantially, and pathological changes mucous membrane tissue still has mild inflammation；
Effective: primary symptom, secondary disease partially remove, and ulcer healing of focus reaches more than 50%；
Invalid: primary symptom, secondary disease are all not improved, ulcer healing of focus is less than 50%.
5, therapeutic outcome
The comparitive study that table 1 is respectively organized
| Project | Case load | Cure number | Effective number | Significant figure | Invalid number | Cure rate | Total effective rate |
| Treat 1 group | 50 | 41 | 4 | 5 | 0 | 82% | 100% |
| Treat 2 groups | 50 | 44 | 3 | 3 | 0 | 88% | 100% |
| Treat 3 groups | 50 | 49 | 1 | 0 | 0 | 98% | 100% |
| Treat 4 groups | 50 | 48 | 2 | 0 | 0 | 96% | 100% |
| Treat 5 groups | 50 | 47 | 1 | 2 | 0 | 94% | 100% |
| Compare 1 group | 50 | 18 | 11 | 4 | 17 | 36% | 66% |
| Compare 2 groups | 50 | 11 | 8 | 7 | 24 | 22% | 52% |
| Compare 3 groups | 50 | 0 | 7 | 12 | 31 | 0% | 38% |
After the treatment of month, the curative effect of each group is as shown in table 1: the cure rate for the treatment of group is 82-98%, and total effective rate is up to 100%；Compared with matched group, the cure rate for the treatment of group and total effective rate are all far superior to matched group, difference statistically significant (P ＜ 0.05), illustrate that in Chinese medicine of the present invention, each component has obvious synergistic function.According to data in above table, Chinese medicine of the present invention have rapid-action, effective percentage is high, determined curative effect, safety is high, have no side effect, the simple advantage of medication；Meanwhile, the most no abnormal according to clinical observation, routine test and Function detection, and follow up a case by regular visits to 1 year, result is added up, and treatment group is without recurrence, and compares 1 group 18 and cure patient, recurs 9 examples, relapse rate 50%, compares 2 group of 11 example and cures patient, recurs 4 examples, relapse rate 36.3%.
6, model case
Case 1: Wang, female, 62 years old, there is epigastrium rest pain in patient, and pain increases the weight of to accompany hematemesis once in a while, previously has gastropathy history, is gastric ulcer after diagnosing.After taking 1 course for the treatment of of granule of the embodiment of the present invention 3 preparation, primary symptom disappears substantially；After continuing to take 1 course for the treatment of, primary symptom, secondary disease partially remove, and ulcer healing of focus reaches 72%.Follow up a case by regular visits to 1 year, do not recur.
Case 2: Lin, man, 38 years old, suffer from serious gastric ulcer, and with perforated ulcer.After taking 2 courses for the treatment of of granule of the embodiment of the present invention 3 preparation, primary symptom, secondary disease all eliminate, and ulcer focus heals substantially, and pathological changes mucous membrane tissue still has mild inflammation.Follow up a case by regular visits to 1 year, do not recur.
Case 3: Lee, female, 26 years old, persistence was suffered from abdominal pain half a year, with upper gastrointestinal hemorrhage, once took the Drug therapys such as magnesium omeprazole enteric coatel tablets, and without alleviating, was gastric ulcer after diagnosing.After taking 2 courses for the treatment of of granule of the embodiment of the present invention 3 preparation, primary symptom, secondary disease all eliminate, fibergastroscopy ulcer healing of focus, and pathological changes mucosa recovers normal.Follow up a case by regular visits to 1 year, do not recur.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, and without departing from the spirit or essential characteristics of the present invention, it is possible to realize the present invention in other specific forms.Therefore, no matter from the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is limited by claims rather than described above, it is intended that all changes fallen in the implication of equivalency and scope of claim included in the present invention.
In addition, it is to be understood that, although this specification is been described by according to embodiment, but the most each embodiment only comprises an independent technical scheme, this narrating mode of description is only for clarity sake, description should can also be formed, through appropriately combined, other embodiments that it will be appreciated by those skilled in the art that as an entirety, the technical scheme in each embodiment by those skilled in the art.
Claims (4)
1. the Chinese medicine treating gastric ulcer, it is characterised in that in parts by weight, composed of the following components: Rhizoma Zingiberis Recens 10-20 part, Pericarpium Citri grandis 25-32 part, Bulbus Allii 8-12 part, Folium Isatidis 5-10 part, Radix Glycyrrhizae 7-10 part, Herba Taraxaci 5-12 part.
The Chinese medicine for the treatment of gastric ulcer the most according to claim 1, it is characterised in that in parts by weight, composed of the following components: Rhizoma Zingiberis Recens 13-17 part, Pericarpium Citri grandis 28-29 part, Bulbus Allii 9-11 part, Folium Isatidis 7-8 part, Radix Glycyrrhizae 8-9 part, Herba Taraxaci 7-10 part.
The Chinese medicine for the treatment of gastric ulcer the most according to claim 1, it is characterised in that in parts by weight, composed of the following components: 15 parts of Rhizoma Zingiberis Recens, Pericarpium Citri grandis 29 parts, 10 parts of Bulbus Allii, Folium Isatidis 8 parts, 9 parts of Radix Glycyrrhizae, Herba Taraxaci 9 parts.
4. according to the preparation method of the arbitrary described Chinese medicine treating gastric ulcer of claim 1-3, it is characterised in that comprise the following steps:
(1) Rhizoma Zingiberis Recens being put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 400 mesh sieves, obtains fine powder, standby；
(2) Bulbus Allii, Herba Taraxaci and Radix Glycyrrhizae are cleaned, pulverize, the ethanol solution that volumetric concentration is 40% of the 4-6 times amount immersing its quality soaks 1-2h, being separately immersed in volumetric concentration subsequently is to carry out gradient elution in 50%, 70%, 90% and 100% ethanol, then low-temperature reduced-pressure extracts 2-3h, temperature 32 DEG C-42 DEG C, pressure 0.6-0.8MPa, reclaim ethanol, with aperture in 2000 μm, molecular cut off obtains filtrate and filtering residue at the membrane filtration of 300KDa, and gained filtrate being concentrated is that at 60 DEG C, relative density is the extractum of 1.18-1.19, standby；
(3) Pericarpium Citri grandis and Folium Isatidis are cleaned, after the water of the 6-8 times amount adding its quality sum together with the filtering residue in step (2) soaks 1-2h, boiled with intense fire, slow fire boiling 3-4h, filters, obtains the first filtrate and the first filtering residue；Then the first filtering residue is added again in the water of 5-6 times amount of its quality, boiled with intense fire, slow fire boiling 2-3h, filters, obtains the second filtrate and the second filtering residue；Finally the second filtering residue is added in the water of 4-5 times amount of its quality, boiled with intense fire, slow fire boiling 1-2h, filters, obtains the 3rd filtrate and the 3rd filtering residue；Merging the first filtrate, the second filtrate and the 3rd filtrate, filter, at concentrating under reduced pressure is 60 DEG C, relative density is the thick paste of 1.21-1.22, standby；
(4) fine powder obtained by above-mentioned steps (1)-(3), extractum and thick paste are mixed, and through Co60 sterilizing, make granule, be the Chinese medicine of described treatment gastric ulcer.
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| CN101172153A (en) * | 2006-10-30 | 2008-05-07 | 上海红点商务咨询服务有限公司 | Coptis chinensis, dried ginger contained traditional Chinese medicine mixture for treating HP masculine |
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