CN105999209A - Traditional Chinese medicine for treating fatty liver and preparing method of traditional Chinese medicine - Google Patents
Traditional Chinese medicine for treating fatty liver and preparing method of traditional Chinese medicine Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/413—Gall bladder; Bile
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a traditional Chinese medicine for treating the fatty liver and a preparing method of the traditional Chinese medicine. The traditional Chinese medicine is prepared from, by weight, 2-10 parts of ginger, 16-22 parts of lily, 10-15 parts of fructus gardeniae, 15-22 parts of ganoderma lucidum, 5-8 parts of radix scutellariae, 10-15 parts of wrinkled gianthyssop herb, 7-10 parts of semen cassiae and 2-7 parts of calculus bovis. Ginger is stir-fried with strong fire to be slightly yellow, cooled, ground and screened, and fine powder is obtained; lily, ganoderma lucidum, radix scutellariae and wrinkled gianthyssop herb are washed clean, immersed into an ethanol solution to be soaked, heated for extraction and filtered, filer liquor and filter residues are obtained, and the obtained filter liquor is concentrated into extract; fructus gardeniae, semen cassiae and calculus bovis are washed clean, water is added into fructus gardeniae, semen cassiae, calculus bovis and the filter residues for soaking, decocting is carried out for extraction, filtering is carried out, and concentration is carried out to obtain thick paste; the fine powder, the extract and the thick paste are mixed and prepared into granules, and the traditional Chinese medicine is obtained. The traditional Chinese medicine preparation is proper in compatibility, has the dual effects of treating and conditioning, has a very good treatment effect on a patient suffering from the fatty liver disease, has the advantages of being easy and convenient to prepare, wide in medicine source, fast in treatment effect, capable of treating the root causes and low in cost, and can be widely and clinically applied and popularized.
Description
Technical field
The present invention relates to technical field of Chinese medicines, a kind of Chinese medicine treating fatty liver and preparation method thereof.
Background technology
Fatty liver refers to due to the pathological changes that athero in the hepatocyte that a variety of causes causes is too much.The health of fatty liver disease positive serious threat compatriots, becomes the second largest hepatopathy being only second to viral hepatitis, has been acknowledged as the common cause of disguised liver cirrhosis.Fatty liver is a kind of common clinical picture, rather than a kind of independent disease.The lighter is asymptomatic in its clinical manifestation, and the severe one state of an illness is violent.It is said that in general, fatty liver belongs to reversibility disease, early diagnosis is also treated in time and often can be recovered normal.In the liver of normal person, total fat mass, accounts for the 5% of liver weight, includes phospholipid, triglyceride, fat acid, cholesterol and cholesterol ester.Fat mass is mild fatty liver more than 5%, is moderate fatty liver more than 10%, is severe fatty liver more than 25%.When fat mass total in liver is more than 30%, could check out with B ultrasonic, be diagnosed as " fatty liver " by ultrasound diagnosis.And Patients with Fatty Liver, total fat amount is up to 40%-50%, and some reaches more than 60%, mainly triglyceride and fat acid, and the most a small amount of increase of phospholipid, cholesterol and cholesterol ester.
Since the eighties in 20th century, the sickness rate of non-alcoholic fatty liver disease (abbreviation fatty liver) is on the increase, and morbidity crowd is gradually in rejuvenation trend.This disease is the most out in the cold in daily life, often delays to abnormal liver function, hepatic fibrosis, even develops into liver cirrhosis.Medical angle is said, due to the impact of the factors such as people's living habit, dietary structure change, in current China pathogenesis of fatty liver rate in the situation increased sharply.Showing according to related data, mostly fatty liver is the initiations such as diabetes, obesity, hepatitis virus or other pathogenic infection.Although having currently on the market much for the Western medicine of fatty liver treatment, but owing to these blood fat reducing Western medicine mostly have potential hepatotoxicity, and action target spot is single, therefore can not obtain the effect of satisfied treatment.Research and develop a kind of effective medicine to fatty liver to be of great practical significance.The history of Chinese medicine fatty liver is of long standing and well established, and as an importance of modern hepatopathy Comprehensive Treatment, the most increasingly receives publicity.People seek single pharmaceutically active ingredient or compound recipe to treat cancer tool challenge from Chinese traditional herbs.Making a general survey of the research direction of world's new drug, mainly research and develop single chemicals and preparation thereof before the eighties, start to develop biotechnology and natural medicinal plants after the eighties, drug research direction tends to multiformity.In conjunction with modern Chinese medicine theory of development, from improving curative effect of medication, the angle of reduction side effect, through Chinese medicine ingredients carries out the preparation that screening is extracted and/or compatibility prepares, its side effect is little, safety height, has the advantage that chemical synthetic drug can not be compared.
Summary of the invention
It is an object of the invention to provide a kind of determined curative effect, Chinese medicine for the treatment of fatty liver that side effect is little and preparation method thereof.
For achieving the above object, the present invention provides following technical scheme:
A kind of Chinese medicine treating fatty liver, in parts by weight, is made up of following raw material: Rhizoma Zingiberis Recens 2-10 part, Bulbus Lilii 16-22 part, Fructus Gardeniae 10-15 part, Ganoderma 15-22 part, Radix Scutellariae 5-8 part, Herba Pogostemonis 10-15 part, Semen Cassiae 7-10 part, Calculus Bovis 2-7 part.
As the further scheme of the present invention: in parts by weight, it is made up of following raw material: Rhizoma Zingiberis Recens 4-8 part, Bulbus Lilii 18-20 part, Fructus Gardeniae 11-14 part, Ganoderma 18-19 part, Radix Scutellariae 6-7 part, Herba Pogostemonis 11-14 part, Semen Cassiae 8-9 part, Calculus Bovis 3-6 part.
As the further scheme of the present invention: in parts by weight, it is made up of following raw material: 6 parts of Rhizoma Zingiberis Recens, Bulbus Lilii 19 parts, Fructus Gardeniae 13 parts, Ganoderma 19 parts, Radix Scutellariae 7 parts, Herba Pogostemonis 13 parts, Semen Cassiae 9 parts, Calculus Bovis 5 parts.
The preparation method of the Chinese medicine of described treatment fatty liver, comprises the following steps:
(1) Rhizoma Zingiberis Recens being put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 600 mesh sieves, obtains fine powder, standby；
(2) by Bulbus Lilii, Ganoderma, Radix Scutellariae, Herba Pogostemonis is cleaned, pulverize with super micron mill, the ethanol solution that volumetric concentration is 50% of the 4-6 times amount immersing its quality soaks 60min, being separately immersed in volumetric concentration subsequently is 55%, 75%, 85% and 100% ethanol carries out gradient rotary evaporation eluting, then low-temperature reduced-pressure extracts 1-2h, temperature 25 DEG C-32 DEG C, pressure 0.7-0.9MPa, reclaim ethanol, with aperture in 2000 μm, molecular cut off obtains filtrate and filtering residue at the membrane filtration of 300KDa, gained filtrate being concentrated is that at 60 DEG C, relative density is the extractum of 1.18-1.19, standby；
(3) Fructus Gardeniae, Semen Cassiae and Calculus Bovis are cleaned, after the water of the 6-8 times amount adding its quality sum together with the filtering residue in step (2) soaks 1-2h, boiled with intense fire, slow fire boiling 3-4h, filters, obtains the first filtrate and the first filtering residue；Then the first filtering residue is added again in the water of 5-6 times amount of its quality, boiled with intense fire, slow fire boiling 2-3h, filters, obtains the second filtrate and the second filtering residue；Finally the second filtering residue is added in the water of 4-5 times amount of its quality, boiled with intense fire, slow fire boiling 1-2h, filters, obtains the 3rd filtrate and the 3rd filtering residue；Merging the first filtrate, the second filtrate and the 3rd filtrate, filter, at concentrating under reduced pressure is 60 DEG C, relative density is the thick paste of 1.20-1.21, standby；
(4) fine powder obtained by above-mentioned steps (1)-(3), extractum and thick paste are mixed, and through Co60 sterilizing, make granule, be the Chinese medicine of described treatment fatty liver.
The instructions of taking of the Chinese medicine of described treatment fatty liver: every day twice, early, evening each the most once, warm boiled water half an hour after meal, each take the dosage being equivalent to 38g crude drug amount.Within 7 days, it is a course for the treatment of, takes effect 3-5 the course for the treatment of.
Compared with prior art, the invention has the beneficial effects as follows:
In Chinese medicine of the present invention, Rhizoma Zingiberis Recens relieving exterior syndrome and dispelling cold, warming middle-JIAO to arrest vomiting, warming the lung to relieve cough, removing toxic substances, Bulbus Lilii nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization, Fructus Gardeniae pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, reducing swelling and alleviating pain, Ganoderma invigorating QI and tranquilization, relieving cough and asthma, Radix Scutellariae clearing heat and moistening dryness, eliminating fire and detoxication, hemostasis, Herba Pogostemonis removing dampness is amusing, ward off dirty and in, expelling summer-heat, deliver, Semen Cassiae liver heat removing and eyesight improving, loosening bowel to relieve constipation, clear away heart-fire, eliminating phlegm, have one's ideas straightened out, cool liver, endogenous wind stopping, all medicine synergism, play removing food stagnancy of regulating the flow of vital energy altogether, clearing away heat-damp and promoting diuresis, temperature compensation Liver and kidney, effect of blood circulation promoting and blood stasis dispelling, treatment for fatty liver has determined curative effect, side effect is little, advantage easy to use, and preparation technology of the present invention is simple, it is prone to industrialized production.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is only a part of embodiment of the present invention rather than whole embodiments.Based on the embodiment in the present invention, the every other embodiment that those of ordinary skill in the art are obtained under not making creative work premise, broadly fall into the scope of protection of the invention.
Embodiment 1
A kind of Chinese medicine treating fatty liver, in parts by weight, is made up of following raw material: 2 parts of Rhizoma Zingiberis Recens, Bulbus Lilii 16 parts, Fructus Gardeniae 10 parts, Ganoderma 15 parts, Radix Scutellariae 5 parts, Herba Pogostemonis 10 parts, Semen Cassiae 7 parts, Calculus Bovis 2 parts.
The preparation method of the Chinese medicine of described treatment fatty liver, comprises the following steps:
(1) Rhizoma Zingiberis Recens being put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 600 mesh sieves, obtains fine powder, standby；
(2) Bulbus Lilii, Ganoderma, Radix Scutellariae, Herba Pogostemonis are cleaned, pulverize with super micron mill, the ethanol solution that volumetric concentration is 50% of 4 times amount immersing its quality soaks 60min, being separately immersed in volumetric concentration subsequently is to carry out gradient rotary evaporation eluting in 55%, 75%, 85% and 100% ethanol, then low-temperature reduced-pressure extracts 1h, temperature 25 DEG C, pressure 0.7MPa, reclaim ethanol, with aperture in 2000 μm, molecular cut off obtains filtrate and filtering residue at the membrane filtration of 300KDa, and gained filtrate being concentrated is that at 60 DEG C, relative density is the extractum of 1.18, standby；
(3) Fructus Gardeniae, Semen Cassiae and Calculus Bovis are cleaned, after the water of 6 times amount adding its quality sum together with the filtering residue in step (2) soaks 1h, boiled with intense fire, slow fire boiling 3h, filters, obtains the first filtrate and the first filtering residue；Then the first filtering residue is added again in the water of 5 times amount of its quality, boiled with intense fire, slow fire boiling 2h, filters, obtains the second filtrate and the second filtering residue；Finally the second filtering residue is added in the water of 4 times amount of its quality, boiled with intense fire, slow fire boiling 1h, filters, obtains the 3rd filtrate and the 3rd filtering residue；Merging the first filtrate, the second filtrate and the 3rd filtrate, filter, at concentrating under reduced pressure is 60 DEG C, relative density is the thick paste of 1.20, standby；
(4) fine powder obtained by above-mentioned steps (1)-(3), extractum and thick paste are mixed, and through Co60 sterilizing, make granule, be the Chinese medicine of described treatment fatty liver.
Embodiment 2
A kind of Chinese medicine treating fatty liver, in parts by weight, is made up of following raw material: 4 parts of Rhizoma Zingiberis Recens, Bulbus Lilii 18 parts, Fructus Gardeniae 11 parts, Ganoderma 18 parts, Radix Scutellariae 6 parts, Herba Pogostemonis 11 parts, Semen Cassiae 8 parts, Calculus Bovis 3 parts.
The preparation method of the Chinese medicine of described treatment fatty liver, comprises the following steps:
(1) Rhizoma Zingiberis Recens being put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 600 mesh sieves, obtains fine powder, standby；
(2) Bulbus Lilii, Ganoderma, Radix Scutellariae, Herba Pogostemonis are cleaned, pulverize with super micron mill, the ethanol solution that volumetric concentration is 50% of 4 times amount immersing its quality soaks 60min, being separately immersed in volumetric concentration subsequently is to carry out gradient rotary evaporation eluting in 55%, 75%, 85% and 100% ethanol, then low-temperature reduced-pressure extracts 1h, temperature 25 DEG C, pressure 0.7MPa, reclaim ethanol, with aperture in 2000 μm, molecular cut off obtains filtrate and filtering residue at the membrane filtration of 300KDa, and gained filtrate being concentrated is that at 60 DEG C, relative density is the extractum of 1.18, standby；
(3) Fructus Gardeniae, Semen Cassiae and Calculus Bovis are cleaned, after the water of 6 times amount adding its quality sum together with the filtering residue in step (2) soaks 1h, boiled with intense fire, slow fire boiling 3h, filters, obtains the first filtrate and the first filtering residue；Then the first filtering residue is added again in the water of 5 times amount of its quality, boiled with intense fire, slow fire boiling 2h, filters, obtains the second filtrate and the second filtering residue；Finally the second filtering residue is added in the water of 4 times amount of its quality, boiled with intense fire, slow fire boiling 1h, filters, obtains the 3rd filtrate and the 3rd filtering residue；Merging the first filtrate, the second filtrate and the 3rd filtrate, filter, at concentrating under reduced pressure is 60 DEG C, relative density is the thick paste of 1.20, standby；
(4) fine powder obtained by above-mentioned steps (1)-(3), extractum and thick paste are mixed, and through Co60 sterilizing, make granule, be the Chinese medicine of described treatment fatty liver.
Embodiment 3
A kind of Chinese medicine treating fatty liver, in parts by weight, is made up of following raw material: 6 parts of Rhizoma Zingiberis Recens, Bulbus Lilii 19 parts, Fructus Gardeniae 13 parts, Ganoderma 19 parts, Radix Scutellariae 7 parts, Herba Pogostemonis 13 parts, Semen Cassiae 9 parts, Calculus Bovis 5 parts.
The preparation method of the Chinese medicine of described treatment fatty liver, comprises the following steps:
(1) Rhizoma Zingiberis Recens being put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 600 mesh sieves, obtains fine powder, standby；
(2) Bulbus Lilii, Ganoderma, Radix Scutellariae, Herba Pogostemonis are cleaned, pulverize with super micron mill, the ethanol solution that volumetric concentration is 50% of 5 times amount immersing its quality soaks 60min, being separately immersed in volumetric concentration subsequently is to carry out gradient rotary evaporation eluting in 55%, 75%, 85% and 100% ethanol, then low-temperature reduced-pressure extracts 1.5h, temperature 29 DEG C, pressure 0.8MPa, reclaim ethanol, with aperture in 2000 μm, molecular cut off obtains filtrate and filtering residue at the membrane filtration of 300KDa, and gained filtrate being concentrated is that at 60 DEG C, relative density is the extractum of 1.19, standby；
(3) Fructus Gardeniae, Semen Cassiae and Calculus Bovis are cleaned, after the water of 7 times amount adding its quality sum together with the filtering residue in step (2) soaks 1.5h, boiled with intense fire, slow fire boiling 3.5h, filters, obtains the first filtrate and the first filtering residue；Then the first filtering residue is added again in the water of 5.5 times amount of its quality, boiled with intense fire, slow fire boiling 2.5h, filters, obtains the second filtrate and the second filtering residue；Finally the second filtering residue is added in the water of 4.5 times amount of its quality, boiled with intense fire, slow fire boiling 1.5h, filters, obtains the 3rd filtrate and the 3rd filtering residue；Merging the first filtrate, the second filtrate and the 3rd filtrate, filter, at concentrating under reduced pressure is 60 DEG C, relative density is the thick paste of 1.21, standby；
(4) fine powder obtained by above-mentioned steps (1)-(3), extractum and thick paste are mixed, and through Co60 sterilizing, make granule, be the Chinese medicine of described treatment fatty liver.
Embodiment 4
A kind of Chinese medicine treating fatty liver, in parts by weight, is made up of following raw material: 8 parts of Rhizoma Zingiberis Recens, Bulbus Lilii 20 parts, Fructus Gardeniae 14 parts, Ganoderma 19 parts, Radix Scutellariae 7 parts, Herba Pogostemonis 14 parts, Semen Cassiae 9 parts, Calculus Bovis 6 parts.
The preparation method of the Chinese medicine of described treatment fatty liver, comprises the following steps:
(1) Rhizoma Zingiberis Recens being put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 600 mesh sieves, obtains fine powder, standby；
(2) Bulbus Lilii, Ganoderma, Radix Scutellariae, Herba Pogostemonis are cleaned, pulverize with super micron mill, the ethanol solution that volumetric concentration is 50% of 6 times amount immersing its quality soaks 60min, being separately immersed in volumetric concentration subsequently is to carry out gradient rotary evaporation eluting in 55%, 75%, 85% and 100% ethanol, then low-temperature reduced-pressure extracts 2h, temperature 32 DEG C, pressure 0.9MPa, reclaim ethanol, with aperture in 2000 μm, molecular cut off obtains filtrate and filtering residue at the membrane filtration of 300KDa, and gained filtrate being concentrated is that at 60 DEG C, relative density is the extractum of 1.19, standby；
(3) Fructus Gardeniae, Semen Cassiae and Calculus Bovis are cleaned, after the water of 8 times amount adding its quality sum together with the filtering residue in step (2) soaks 2h, boiled with intense fire, slow fire boiling 4h, filters, obtains the first filtrate and the first filtering residue；Then the first filtering residue is added again in the water of 6 times amount of its quality, boiled with intense fire, slow fire boiling 3h, filters, obtains the second filtrate and the second filtering residue；Finally the second filtering residue is added in the water of 5 times amount of its quality, boiled with intense fire, slow fire boiling 2h, filters, obtains the 3rd filtrate and the 3rd filtering residue；Merging the first filtrate, the second filtrate and the 3rd filtrate, filter, at concentrating under reduced pressure is 60 DEG C, relative density is the thick paste of 1.21, standby；
(4) fine powder obtained by above-mentioned steps (1)-(3), extractum and thick paste are mixed, and through Co60 sterilizing, make granule, be the Chinese medicine of described treatment fatty liver.
Embodiment 5
A kind of Chinese medicine treating fatty liver, in parts by weight, is made up of following raw material: 10 parts of Rhizoma Zingiberis Recens, Bulbus Lilii 22 parts, Fructus Gardeniae 15 parts, Ganoderma 22 parts, Radix Scutellariae 8 parts, Herba Pogostemonis 15 parts, Semen Cassiae 10 parts, Calculus Bovis 7 parts.
The preparation method of the Chinese medicine of described treatment fatty liver, comprises the following steps:
(1) Rhizoma Zingiberis Recens being put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 600 mesh sieves, obtains fine powder, standby；
(2) Bulbus Lilii, Ganoderma, Radix Scutellariae, Herba Pogostemonis are cleaned, pulverize with super micron mill, the ethanol solution that volumetric concentration is 50% of 6 times amount immersing its quality soaks 60min, being separately immersed in volumetric concentration subsequently is to carry out gradient rotary evaporation eluting in 55%, 75%, 85% and 100% ethanol, then low-temperature reduced-pressure extracts 2h, temperature 32 DEG C, pressure 0.9MPa, reclaim ethanol, with aperture in 2000 μm, molecular cut off obtains filtrate and filtering residue at the membrane filtration of 300KDa, and gained filtrate being concentrated is that at 60 DEG C, relative density is the extractum of 1.19, standby；
(3) Fructus Gardeniae, Semen Cassiae and Calculus Bovis are cleaned, after the water of 8 times amount adding its quality sum together with the filtering residue in step (2) soaks 2h, boiled with intense fire, slow fire boiling 4h, filters, obtains the first filtrate and the first filtering residue；Then the first filtering residue is added again in the water of 6 times amount of its quality, boiled with intense fire, slow fire boiling 3h, filters, obtains the second filtrate and the second filtering residue；Finally the second filtering residue is added in the water of 5 times amount of its quality, boiled with intense fire, slow fire boiling 2h, filters, obtains the 3rd filtrate and the 3rd filtering residue；Merging the first filtrate, the second filtrate and the 3rd filtrate, filter, at concentrating under reduced pressure is 60 DEG C, relative density is the thick paste of 1.21, standby；
(4) fine powder obtained by above-mentioned steps (1)-(3), extractum and thick paste are mixed, and through Co60 sterilizing, make granule, be the Chinese medicine of described treatment fatty liver.
Drug toxicology is tested
1, acute toxicity test
With the prepared granule of the embodiment of the present invention 3 for test, using gastric infusion mode, successive administration 3 times in 24h, every minor tick 4h, be administered 80g crude drug amount every time, accumulation medicine total amount reaches 240g crude drug/kg, is equivalent to 80 times of people's quantity.After administration in 7d, mice is movable, take food, drain all normally, well-grown, and hair color light, its average body weight average increases with the prolongation of experimental period.Post mortem every mice at 8d, the perusal heart, liver, spleen, lung, kidney, brain, thymus, stomach, intestinal etc. all do not find color and paramophia, fail to measure median lethal dose(LD 50) (LD50).Result shows: Chinese medicine of the present invention is without acute toxic reaction.
2, long term toxicity test
With the prepared granule of the embodiment of the present invention 3 for test, use gastric infusion mode, Chinese medicine of the present invention is divided into low dosage, middle dosage, high dose three groups, the drug dose of each group is respectively 30,60,120g crude drug/kg/d, be equivalent to the 10 of clinical dosage, 20,40 times.After gastric infusion 24 weeks, Chinese medicine of the present invention on the general status of animal, hematological indices, blood parameters all without significantly impact, the most no abnormal pathological change of Systematic anatomy, organ coefficient and histopathological examination.Drug withdrawal also has no substantially change for 2 weeks.Result shows: Chinese medicine of the present invention, in long term toxicity test, does not finds that overt toxicity reaction and delayed toxicity react.Visible, Chinese medicine non-toxic reaction of the present invention, long-term prescription is safe and reliable.
Clinical data
1, case selection
Select the fatty liver 400 example clinical observation made a definite diagnosis, the maleest 237 examples, women 163 example, age 25-65 year, 36.2 years old mean age.This 400 example patient being randomly divided into treatment 1-5 group, comparison 1-3 group totally eight groups, often organizes 50 examples, each group course of disease of case, degrees of symptoms are basically identical, without significant difference, have comparability.
2, diagnostic criteria
By the diagnostic criteria that " internal medicine " the 8th edition is fatty liver.
3, Therapeutic Method
Treatment 1-5 group: take granule prepared by embodiment of the present invention 1-5 respectively, every day twice, early, evening each the most once, warm boiled water half an hour after meal, each take the dosage being equivalent to 38g crude drug amount.It within 7 days, it is a course for the treatment of.
Compareing 1 group: sunflower liver-protecting tablet (Heilongjiang Kuihua Yaoye Co.Ltd Co., Ltd) 360mg, each 4, three times a day, 7 days be 1 course for the treatment of.
Compareing 2 groups: the granule taken, contain only Rhizoma Zingiberis Recens, Bulbus Lilii both components, remaining is identical with embodiment 3.Every day twice, early, evening each the most once, warm boiled water half an hour after meal, each take the dosage being equivalent to 38g crude drug amount.It within 7 days, it is a course for the treatment of.
Compareing 3 groups: the granule taken, contain only this kind of component of Rhizoma Zingiberis Recens, remaining is identical with embodiment 3.Every day twice, early, evening each the most once, warm boiled water half an hour after meal, each take the dosage being equivalent to 38g crude drug amount.It within 7 days, it is a course for the treatment of.
4, the standard of curative effect evaluation
Therapeutic evaluation is carried out with reference to " Chinese medical disease Standardization of diagnosis and curative effect ".
Cure: transference cure, how subnormal lab testing is；
Take a turn for the better: cardinal symptom and relevant lab testing have improvement；
Do not heal: symptom and lab testing are unchanged.
5, therapeutic outcome
The comparitive study that table 1 is respectively organized
| Project | Case load | Cure number | Good revolution | Several | Cure rate | Total effective rate |
| Treat 1 group | 50 | 43 | 2 | 5 | 86% | 90% |
| Treat 2 groups | 50 | 45 | 3 | 2 | 90% | 96% |
| Treat 3 groups | 50 | 48 | 2 | 0 | 96% | 100% |
| Treat 4 groups | 50 | 48 | 0 | 2 | 96% | 96% |
| Treat 5 groups | 50 | 46 | 2 | 2 | 92% | 96% |
| Compare 1 group | 50 | 22 | 5 | 23 | 44% | 54% |
| Compare 2 groups | 50 | 6 | 5 | 39 | 12% | 22% |
| Compare 3 groups | 50 | 0 | 5 | 45 | 0% | 10% |
After the treatment of month, the curative effect of each group is as shown in table 1: the cure rate for the treatment of group is 86-96%, and total effective rate is up to more than 90%；Compared with matched group, the cure rate for the treatment of group and total effective rate are all far superior to matched group, difference statistically significant (P ＜ 0.05), illustrate that in Chinese medicine of the present invention, each component has obvious synergistic function.According to data in above table, Chinese medicine of the present invention have rapid-action, effective percentage is high, determined curative effect, safety is high, have no side effect, the simple advantage of medication；Meanwhile, the most no abnormal according to clinical observation, routine test and Function detection, and follow up a case by regular visits to 1 year, result is added up, treatment group is without recurrence, and compares 1 group of 22 example and cure patient, recurs 15 examples, relapse rate 68.2%, compare 2 group of 6 example and cure patient, recur 4 examples, relapse rate 66.7%.
6, model case
Case 1: Ma, man, 61 years old, be diagnosed as moderate fatty liver, and with Nausea and vomiting, detest the symptom such as oil, big belly.After taking 1 course for the treatment of of granule of the embodiment of the present invention 3 preparation, cardinal symptom and relevant lab testing have improvement；After continuing to take 2 courses for the treatment of, transference cure, how subnormal lab testing is.Follow up a case by regular visits to 1 year, do not recur.
Case 2: land, man, 40 years old, suffer from Severe fatty liver, and with asthma, abdominal part swelling.After taking 3 courses for the treatment of of granule of the embodiment of the present invention 3 preparation, transference cure, how subnormal lab testing is.Follow up a case by regular visits to 1 year, do not recur.
Case 3: Jiang, female, 29 years old, fatigue and asthenia, soreness of the waist and knees, menorrhagia, once took the Drug therapys such as sunflower liver-protecting tablet, without alleviating, be mild fatty liver after diagnosing.After taking 1 course for the treatment of of granule of the embodiment of the present invention 3 preparation, transference cure, how subnormal lab testing is.Follow up a case by regular visits to 1 year, do not recur.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, and without departing from the spirit or essential characteristics of the present invention, it is possible to realize the present invention in other specific forms.Therefore, no matter from the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is limited by claims rather than described above, it is intended that all changes fallen in the implication of equivalency and scope of claim included in the present invention.
In addition, it is to be understood that, although this specification is been described by according to embodiment, but the most each embodiment only comprises an independent technical scheme, this narrating mode of description is only for clarity sake, description should can also be formed, through appropriately combined, other embodiments that it will be appreciated by those skilled in the art that as an entirety, the technical scheme in each embodiment by those skilled in the art.
Claims (4)
1. the Chinese medicine treating fatty liver; it is characterized in that; in parts by weight, it is made up of following raw material: Rhizoma Zingiberis Recens 2-10 part, Bulbus Lilii 16-22 part, Fructus Gardeniae 10-15 part, Ganoderma 15-22 part, Radix Scutellariae 5-8 part, Herba Pogostemonis 10-15 part, Semen Cassiae 7-10 part, Calculus Bovis 2-7 part.
The Chinese medicine for the treatment of fatty liver the most according to claim 1, it is characterised in that in parts by weight, is made up of following raw material: Rhizoma Zingiberis Recens 4-8 part, Bulbus Lilii 18-20 part, Fructus Gardeniae 11-14 part, Ganoderma 18-19 part, Radix Scutellariae 6-7 part, Herba Pogostemonis.
The Chinese medicine for the treatment of fatty liver the most according to claim 1, it is characterised in that in parts by weight, is made up of following raw material: 6 parts of Rhizoma Zingiberis Recens, Bulbus Lilii 19 parts, Fructus Gardeniae 13 parts, Ganoderma 19 parts, Radix Scutellariae 7 parts, Herba Pogostemonis 13 parts, Semen Cassiae 9 parts, Calculus Bovis 5 parts.
4. according to the preparation method of the arbitrary described Chinese medicine treating fatty liver of claim 1-3, it is characterised in that comprise the following steps:
(1) Rhizoma Zingiberis Recens being put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 600 mesh sieves, obtains fine powder, standby；
(2) by Bulbus Lilii, Ganoderma, Radix Scutellariae, Herba Pogostemonis is cleaned, pulverize with super micron mill, the ethanol solution that volumetric concentration is 50% of the 4-6 times amount immersing its quality soaks 60min, being separately immersed in volumetric concentration subsequently is 55%, 75%, 85% and 100% ethanol carries out gradient rotary evaporation eluting, then low-temperature reduced-pressure extracts 1-2h, temperature 25 DEG C-32 DEG C, pressure 0.7-0.9MPa, reclaim ethanol, with aperture in 2000 μm, molecular cut off obtains filtrate and filtering residue at the membrane filtration of 300KDa, gained filtrate being concentrated is that at 60 DEG C, relative density is the extractum of 1.18-1.19, standby；
(3) Fructus Gardeniae, Semen Cassiae and Calculus Bovis are cleaned, after the water of the 6-8 times amount adding its quality sum together with the filtering residue in step (2) soaks 1-2h, boiled with intense fire, slow fire boiling 3-4h, filters, obtains the first filtrate and the first filtering residue；Then the first filtering residue is added again in the water of 5-6 times amount of its quality, boiled with intense fire, slow fire boiling 2-3h, filters, obtains the second filtrate and the second filtering residue；Finally the second filtering residue is added in the water of 4-5 times amount of its quality, boiled with intense fire, slow fire boiling 1-2h, filters, obtains the 3rd filtrate and the 3rd filtering residue；Merging the first filtrate, the second filtrate and the 3rd filtrate, filter, at concentrating under reduced pressure is 60 DEG C, relative density is the thick paste of 1.20-1.21, standby；
(4) fine powder obtained by above-mentioned steps (1)-(3), extractum and thick paste are mixed, and through Co60 sterilizing, make granule, be the Chinese medicine of described treatment fatty liver.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111012847A (en) * | 2020-01-07 | 2020-04-17 | 包纳日斯 | Mongolian medicine for treating non-alcoholic fatty liver and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101401925A (en) * | 2008-11-06 | 2009-04-08 | 张晨 | Traditional Chinese medicine decoction for treating fatty liver |
| CN102727619A (en) * | 2012-06-14 | 2012-10-17 | 漳州片仔癀药业股份有限公司 | Medicinal composition treating fatty liver and preparations thereof |
| CN104208275A (en) * | 2014-08-29 | 2014-12-17 | 雷允上药业有限公司 | Composition with effects of improving fatty liver and lowering body weight, as well as preparation method and application of composition |
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2016
- 2016-08-18 CN CN201610679894.0A patent/CN105999209A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101401925A (en) * | 2008-11-06 | 2009-04-08 | 张晨 | Traditional Chinese medicine decoction for treating fatty liver |
| CN102727619A (en) * | 2012-06-14 | 2012-10-17 | 漳州片仔癀药业股份有限公司 | Medicinal composition treating fatty liver and preparations thereof |
| CN104208275A (en) * | 2014-08-29 | 2014-12-17 | 雷允上药业有限公司 | Composition with effects of improving fatty liver and lowering body weight, as well as preparation method and application of composition |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111012847A (en) * | 2020-01-07 | 2020-04-17 | 包纳日斯 | Mongolian medicine for treating non-alcoholic fatty liver and preparation method thereof |
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