CN105998828A - Traditional Chinese medicine for treating constipation and preparing method thereof - Google Patents
Traditional Chinese medicine for treating constipation and preparing method thereof Download PDFInfo
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- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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Abstract
The invention discloses a traditional Chinese medicine for treating constipation and a preparing method thereof. The traditional Chinese medicine is prepared from, by weight, 8-15 parts of radix rehmanniae, 10-15 parts of gallnut, 28-35 parts of aloe, 18-26 parts of dendrobium, 15-20 parts of bamboo leaves, 12-15 parts of prunella vulgaris, 7-10 parts of semen cassia and 8-12 parts of honey. The preparing method includes the steps that the radix rehmanniae is fried with strong fire to be slightly yellow, cooled, ground and sieved, and fine powder is obtained; the aloe, the dendrobium, the bamboo leaves and the prunella vulgaris are clearly washed, soaked into an ethanol solution, heated, extracted and filtered, filter liquor and filtered residues are obtained, and the obtained filter liquor is concentrated into extract; the gallnut, the semen cassia and the honey are clearly washed, then the gallnut, the semen cassia, the honey and the filtered residues are soaked with water, decocted, extracted and filtered, the product is concentrated into thick paste; the fine powder, the extract and the thick paste are mixed and prepared into particles, and the traditional Chinese medicine is obtained. According to the traditional Chinese medicine and the preparing method, compatibility of the medicinal materials is proper, the treatment effect and the health nursing effect are achieved, the good treatment effect on constipation patients is achieved, and the traditional Chinese medicine has the advantages of being easy and convenient to prepare, wide in medicine source, capable of treating roots and low in cost, and rapidly taking the effect, and can be widely applied and popularized in clinic.
Description
Technical field
The present invention relates to technical field of Chinese medicines, a kind of Chinese medicine treating constipation and preparation method thereof.
Background technology
Constipation is a kind of common multiple disease, has a strong impact on the orthobiosis of people, and often induces other diseases, such as when stool is discharged not smooth, if Overexertion is held one's breath, abdominal pressure can be increased, blood pressure raises the most simultaneously, can induce angina pectoris, myocardial infarction, cerebral hemorrhage, apoplexy sudden death etc.；Constipation throughout the year can cause quality of life to decline, and goes to bits, even causes fatal serious consequence.The traditional Chinese medical science of our country thinks that constipation is that constipation is obstructed, and defecation time extends or is intended to defecate and the most smooth involved and abstruse a kind of disease, mainly by caused by dryness-heat stagnating in the interior, depression and stagnation of QI, deficiency of body fluid and spleen-kidney vacuity cold.And typically it is mainly cathartic class medicine with defecation for primary treatment purpose Western medicine, all there is toxic and side effects in various degree and bad reflection.Simultaneously as constipation has the feature of recurrent exerbation, using cathartic treatment can produce drug resistance, patient is difficult to accept for a long time western medicine more, and last issue to eat cathartic the biggest to physical impairment.
Summary of the invention
It is an object of the invention to provide a kind of determined curative effect, Chinese medicine for the treatment of constipation that side effect is little and preparation method thereof.
For achieving the above object, the present invention provides following technical scheme:
A kind of Chinese medicine treating constipation, in parts by weight, is made up of following raw material: Radix Rehmanniae 8-15 part, Galla Chinensis 10-15 part, Aloe 28-35 part, Herba Dendrobii 18-26 part, Folium Bambusae 15-20 part, Spica Prunellae 12-15 part, Semen Cassiae 7-10 part, Mel 8-12 part.
As the further scheme of the present invention: in parts by weight, it is made up of following raw material: Radix Rehmanniae 10-13 part, Galla Chinensis 12-13 part, Aloe 30-33 part, Herba Dendrobii 20-24 part, Folium Bambusae 16-19 part, Spica Prunellae 13-14 part, Semen Cassiae 8-9 part, Mel 9-11 part.
As the further scheme of the present invention: in parts by weight, it is made up of following raw material: Radix Rehmanniae 12 parts, Galla Chinensis 13 parts, Aloe 32 parts, Herba Dendrobii 22 parts, 18 parts of Folium Bambusae, Spica Prunellae 14 parts, Semen Cassiae 9 parts, Mel 10 parts.
The preparation method of the Chinese medicine of described treatment constipation, comprises the following steps:
(1) Radix Rehmanniae being put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 600 mesh sieves, obtains fine powder, standby；
(2) by Aloe, Herba Dendrobii, Folium Bambusae and Spica Prunellae are cleaned, pulverize with super micron mill, the ethanol solution that volumetric concentration is 50% of the 4-6 times amount immersing its quality soaks 60min, being separately immersed in volumetric concentration subsequently is 55%, 75%, 85% and 100% ethanol carries out gradient rotary evaporation eluting, then low-temperature reduced-pressure extracts 1-2h, temperature 45 C-52 DEG C, pressure 0.7-0.9MPa, reclaim ethanol, with aperture in 2000 μm, molecular cut off obtains filtrate and filtering residue at the membrane filtration of 300KDa, gained filtrate being concentrated is that at 60 DEG C, relative density is the extractum of 1.16-1.17, standby；
(3) Galla Chinensis, Semen Cassiae and Mel are cleaned, after the water of the 6-8 times amount adding its quality sum together with the filtering residue in step (2) soaks 1-2h, boiled with intense fire, slow fire boiling 3-4h, filters, obtains the first filtrate and the first filtering residue；Then the first filtering residue is added again in the water of 5-6 times amount of its quality, boiled with intense fire, slow fire boiling 2-3h, filters, obtains the second filtrate and the second filtering residue；Finally the second filtering residue is added in the water of 4-5 times amount of its quality, boiled with intense fire, slow fire boiling 1-2h, filters, obtains the 3rd filtrate and the 3rd filtering residue；Merging the first filtrate, the second filtrate and the 3rd filtrate, filter, at concentrating under reduced pressure is 60 DEG C, relative density is the thick paste of 1.23-1.24, standby；
(4) fine powder obtained by above-mentioned steps (1)-(3), extractum and thick paste are mixed, and through Co60 sterilizing, make granule, be the Chinese medicine of described treatment constipation.
The instructions of taking of the Chinese medicine of described treatment constipation: every day twice, early, evening each the most once, warm boiled water half an hour after meal, each take the dosage being equivalent to 45g crude drug amount.Within 5 days, it is a course for the treatment of, takes effect 3-5 the course for the treatment of.
Compared with prior art, the invention has the beneficial effects as follows:
In Chinese medicine of the present invention, Radix Rehmanniae clearing away heat and cooling blood, yin nourishing, promote the production of body fluid, Galla Chinensis is astringed the lung pathogenic fire reducing, relieving diarrhea with astringents, arresting sweating stops blooding, removing dampness sore, Aloe pathogenic fire purging, understand, blood stasis dispelling, Herba Dendrobii reinforcing stomach reg fluid, nourishing YIN and clearing away heat, Folium Bambusae clearing heat and relieving fidgetness, promote the production of body fluid diuresis, only quench one's thirst, expectorant, spasmolytic is throbbed with fear, reducing the asthenic fever, born fluid, Spica Prunellae purging liver-fire, improving eyesight, mass dissipating and swelling eliminating, Semen Cassiae liver heat removing and eyesight improving, loosening bowel to relieve constipation, Mel harmonizing the spleen and stomach, relieving spasm to stop pain, nourishing the lung to arrest cough, loosening bowel to relieve constipation, all medicine synergism, play invigorating the spleen and benefiting QI altogether, warming the meridian purging FU-organs, effect of loosening bowel to relieve constipation, treatment for constipation has determined curative effect, side effect is little, advantage easy to use, and preparation technology of the present invention is simple, it is prone to industrialized production.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is only a part of embodiment of the present invention rather than whole embodiments.Based on the embodiment in the present invention, the every other embodiment that those of ordinary skill in the art are obtained under not making creative work premise, broadly fall into the scope of protection of the invention.
Embodiment 1
A kind of Chinese medicine treating constipation, in parts by weight, is made up of following raw material: Radix Rehmanniae 8 parts, Galla Chinensis 10 parts, Aloe 28 parts, Herba Dendrobii 18 parts, 15 parts of Folium Bambusae, Spica Prunellae 12 parts, Semen Cassiae 7 parts, Mel 8 parts.
The preparation method of the Chinese medicine of described treatment constipation, comprises the following steps:
(1) Radix Rehmanniae being put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 600 mesh sieves, obtains fine powder, standby；
(2) Aloe, Herba Dendrobii, Folium Bambusae and Spica Prunellae are cleaned, pulverize with super micron mill, the ethanol solution that volumetric concentration is 50% of 4 times amount immersing its quality soaks 60min, being separately immersed in volumetric concentration subsequently is to carry out gradient rotary evaporation eluting in 55%, 75%, 85% and 100% ethanol, then low-temperature reduced-pressure extracts 1h, temperature 45 C, pressure 0.7MPa, reclaim ethanol, with aperture in 2000 μm, molecular cut off obtains filtrate and filtering residue at the membrane filtration of 300KDa, and gained filtrate being concentrated is that at 60 DEG C, relative density is the extractum of 1.16, standby；
(3) Galla Chinensis, Semen Cassiae and Mel are cleaned, after the water of 6 times amount adding its quality sum together with the filtering residue in step (2) soaks 1h, boiled with intense fire, slow fire boiling 3h, filters, obtains the first filtrate and the first filtering residue；Then the first filtering residue is added again in the water of 5 times amount of its quality, boiled with intense fire, slow fire boiling 2h, filters, obtains the second filtrate and the second filtering residue；Finally the second filtering residue is added in the water of 4 times amount of its quality, boiled with intense fire, slow fire boiling 1h, filters, obtains the 3rd filtrate and the 3rd filtering residue；Merging the first filtrate, the second filtrate and the 3rd filtrate, filter, at concentrating under reduced pressure is 60 DEG C, relative density is the thick paste of 1.23, standby；
(4) fine powder obtained by above-mentioned steps (1)-(3), extractum and thick paste are mixed, and through Co60 sterilizing, make granule, be the Chinese medicine of described treatment constipation.
Embodiment 2
A kind of Chinese medicine treating constipation, in parts by weight, is made up of following raw material: Radix Rehmanniae 10 parts, Galla Chinensis 12 parts, Aloe 30 parts, Herba Dendrobii 20 parts, 16 parts of Folium Bambusae, Spica Prunellae 13 parts, Semen Cassiae 8 parts, Mel 9 parts.
The preparation method of the Chinese medicine of described treatment constipation, comprises the following steps:
(1) Radix Rehmanniae being put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 600 mesh sieves, obtains fine powder, standby；
(2) Aloe, Herba Dendrobii, Folium Bambusae and Spica Prunellae are cleaned, pulverize with super micron mill, the ethanol solution that volumetric concentration is 50% of 4 times amount immersing its quality soaks 60min, being separately immersed in volumetric concentration subsequently is to carry out gradient rotary evaporation eluting in 55%, 75%, 85% and 100% ethanol, then low-temperature reduced-pressure extracts 1h, temperature 45 C, pressure 0.7MPa, reclaim ethanol, with aperture in 2000 μm, molecular cut off obtains filtrate and filtering residue at the membrane filtration of 300KDa, and gained filtrate being concentrated is that at 60 DEG C, relative density is the extractum of 1.16, standby；
(3) Galla Chinensis, Semen Cassiae and Mel are cleaned, after the water of 6 times amount adding its quality sum together with the filtering residue in step (2) soaks 1h, boiled with intense fire, slow fire boiling 3h, filters, obtains the first filtrate and the first filtering residue；Then the first filtering residue is added again in the water of 5 times amount of its quality, boiled with intense fire, slow fire boiling 2h, filters, obtains the second filtrate and the second filtering residue；Finally the second filtering residue is added in the water of 4 times amount of its quality, boiled with intense fire, slow fire boiling 1h, filters, obtains the 3rd filtrate and the 3rd filtering residue；Merging the first filtrate, the second filtrate and the 3rd filtrate, filter, at concentrating under reduced pressure is 60 DEG C, relative density is the thick paste of 1.23, standby；
(4) fine powder obtained by above-mentioned steps (1)-(3), extractum and thick paste are mixed, and through Co60 sterilizing, make granule, be the Chinese medicine of described treatment constipation.
Embodiment 3
A kind of Chinese medicine treating constipation, in parts by weight, is made up of following raw material: Radix Rehmanniae 12 parts, Galla Chinensis 13 parts, Aloe 32 parts, Herba Dendrobii 22 parts, 18 parts of Folium Bambusae, Spica Prunellae 14 parts, Semen Cassiae 9 parts, Mel 10 parts.
The preparation method of the Chinese medicine of described treatment constipation, comprises the following steps:
(1) Radix Rehmanniae being put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 600 mesh sieves, obtains fine powder, standby；
(2) Aloe, Herba Dendrobii, Folium Bambusae and Spica Prunellae are cleaned, pulverize with super micron mill, the ethanol solution that volumetric concentration is 50% of 5 times amount immersing its quality soaks 60min, being separately immersed in volumetric concentration subsequently is to carry out gradient rotary evaporation eluting in 55%, 75%, 85% and 100% ethanol, then low-temperature reduced-pressure extracts 1.5h, temperature 48 DEG C, pressure 0.8MPa, reclaim ethanol, with aperture in 2000 μm, molecular cut off obtains filtrate and filtering residue at the membrane filtration of 300KDa, and gained filtrate being concentrated is that at 60 DEG C, relative density is the extractum of 1.17, standby；
(3) Galla Chinensis, Semen Cassiae and Mel are cleaned, after the water of 7 times amount adding its quality sum together with the filtering residue in step (2) soaks 1.5h, boiled with intense fire, slow fire boiling 3.5h, filters, obtains the first filtrate and the first filtering residue；Then the first filtering residue is added again in the water of 5.5 times amount of its quality, boiled with intense fire, slow fire boiling 2.5h, filters, obtains the second filtrate and the second filtering residue；Finally the second filtering residue is added in the water of 4.5 times amount of its quality, boiled with intense fire, slow fire boiling 1.5h, filters, obtains the 3rd filtrate and the 3rd filtering residue；Merging the first filtrate, the second filtrate and the 3rd filtrate, filter, at concentrating under reduced pressure is 60 DEG C, relative density is the thick paste of 1.24, standby；
(4) fine powder obtained by above-mentioned steps (1)-(3), extractum and thick paste are mixed, and through Co60 sterilizing, make granule, be the Chinese medicine of described treatment constipation.
Embodiment 4
A kind of Chinese medicine treating constipation, in parts by weight, is made up of following raw material: Radix Rehmanniae 13 parts, Galla Chinensis 13 parts, Aloe 33 parts, Herba Dendrobii 24 parts, 19 parts of Folium Bambusae, Spica Prunellae 14 parts, Semen Cassiae 9 parts, Mel 11 parts.
The preparation method of the Chinese medicine of described treatment constipation, comprises the following steps:
(1) Radix Rehmanniae being put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 600 mesh sieves, obtains fine powder, standby；
(2) Aloe, Herba Dendrobii, Folium Bambusae and Spica Prunellae are cleaned, pulverize with super micron mill, the ethanol solution that volumetric concentration is 50% of 6 times amount immersing its quality soaks 60min, being separately immersed in volumetric concentration subsequently is to carry out gradient rotary evaporation eluting in 55%, 75%, 85% and 100% ethanol, then low-temperature reduced-pressure extracts 2h, temperature 52 DEG C, pressure 0.9MPa, reclaim ethanol, with aperture in 2000 μm, molecular cut off obtains filtrate and filtering residue at the membrane filtration of 300KDa, and gained filtrate being concentrated is that at 60 DEG C, relative density is the extractum of 1.17, standby；
(3) Galla Chinensis, Semen Cassiae and Mel are cleaned, after the water of 8 times amount adding its quality sum together with the filtering residue in step (2) soaks 2h, boiled with intense fire, slow fire boiling 4h, filters, obtains the first filtrate and the first filtering residue；Then the first filtering residue is added again in the water of 6 times amount of its quality, boiled with intense fire, slow fire boiling 3h, filters, obtains the second filtrate and the second filtering residue；Finally the second filtering residue is added in the water of 4-5 times amount of its quality, boiled with intense fire, slow fire boiling 2h, filters, obtains the 3rd filtrate and the 3rd filtering residue；Merging the first filtrate, the second filtrate and the 3rd filtrate, filter, at concentrating under reduced pressure is 60 DEG C, relative density is the thick paste of 1.24, standby；
(4) fine powder obtained by above-mentioned steps (1)-(3), extractum and thick paste are mixed, and through Co60 sterilizing, make granule, be the Chinese medicine of described treatment constipation.
Embodiment 5
A kind of Chinese medicine treating constipation, in parts by weight, is made up of following raw material: Radix Rehmanniae 15 parts, Galla Chinensis 15 parts, Aloe 35 parts, Herba Dendrobii 26 parts, 20 parts of Folium Bambusae, Spica Prunellae 15 parts, Semen Cassiae 10 parts, Mel 12 parts.
The preparation method of the Chinese medicine of described treatment constipation, comprises the following steps:
(1) Radix Rehmanniae being put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 600 mesh sieves, obtains fine powder, standby；
(2) Aloe, Herba Dendrobii, Folium Bambusae and Spica Prunellae are cleaned, pulverize with super micron mill, the ethanol solution that volumetric concentration is 50% of 6 times amount immersing its quality soaks 60min, being separately immersed in volumetric concentration subsequently is to carry out gradient rotary evaporation eluting in 55%, 75%, 85% and 100% ethanol, then low-temperature reduced-pressure extracts 2h, temperature 52 DEG C, pressure 0.9MPa, reclaim ethanol, with aperture in 2000 μm, molecular cut off obtains filtrate and filtering residue at the membrane filtration of 300KDa, and gained filtrate being concentrated is that at 60 DEG C, relative density is the extractum of 1.17, standby；
(3) Galla Chinensis, Semen Cassiae and Mel are cleaned, after the water of 8 times amount adding its quality sum together with the filtering residue in step (2) soaks 2h, boiled with intense fire, slow fire boiling 4h, filters, obtains the first filtrate and the first filtering residue；Then the first filtering residue is added again in the water of 6 times amount of its quality, boiled with intense fire, slow fire boiling 3h, filters, obtains the second filtrate and the second filtering residue；Finally the second filtering residue is added in the water of 5 times amount of its quality, boiled with intense fire, slow fire boiling 2h, filters, obtains the 3rd filtrate and the 3rd filtering residue；Merging the first filtrate, the second filtrate and the 3rd filtrate, filter, at concentrating under reduced pressure is 60 DEG C, relative density is the thick paste of 1.24, standby；
(4) fine powder obtained by above-mentioned steps (1)-(3), extractum and thick paste are mixed, and through Co60 sterilizing, make granule, be the Chinese medicine of described treatment constipation.
Drug toxicology is tested
1, acute toxicity test
With the prepared granule of the embodiment of the present invention 3 for test, using gastric infusion mode, successive administration 3 times in 24h, every minor tick 4h, be administered 80g crude drug amount every time, accumulation medicine total amount reaches 240g crude drug/kg, is equivalent to 80 times of people's quantity.After administration in 7d, mice is movable, take food, drain all normally, well-grown, and hair color light, its average body weight average increases with the prolongation of experimental period.Post mortem every mice at 8d, the perusal heart, liver, spleen, lung, kidney, brain, thymus, stomach, intestinal etc. all do not find color and paramophia, fail to measure median lethal dose(LD 50) (LD50).Result shows: Chinese medicine of the present invention is without acute toxic reaction.
2, long term toxicity test
With the prepared granule of the embodiment of the present invention 3 for test, use gastric infusion mode, Chinese medicine of the present invention is divided into low dosage, middle dosage, high dose three groups, the drug dose of each group is respectively 30,60,120g crude drug/kg/d, be equivalent to the 10 of clinical dosage, 20,40 times.After gastric infusion 24 weeks, Chinese medicine of the present invention on the general status of animal, hematological indices, blood parameters all without significantly impact, the most no abnormal pathological change of Systematic anatomy, organ coefficient and histopathological examination.Drug withdrawal also has no substantially change for 2 weeks.Result shows: Chinese medicine of the present invention, in long term toxicity test, does not finds that overt toxicity reaction and delayed toxicity react.Visible, Chinese medicine non-toxic reaction of the present invention, long-term prescription is safe and reliable.
Clinical data
1, case selection
Select the constipation 400 example clinical observation made a definite diagnosis, the maleest 148 examples, women 252 example, age 25-65 year, 39.4 years old mean age.This 400 example patient being randomly divided into treatment 1-5 group, comparison 1-3 group totally eight groups, often organizes 50 examples, each group course of disease of case, degrees of symptoms are basically identical, without significant difference, have comparability.
2, diagnostic criteria
By the diagnostic criteria that " internal medicine " the 8th edition is constipation.
3, Therapeutic Method
Treatment 1-5 group: take granule prepared by embodiment of the present invention 1-5 respectively, every day twice, early, evening each the most once, warm boiled water half an hour after meal, each take the dosage being equivalent to 45g crude drug amount.Within 5 days, it is a course for the treatment of, takes effect 3-5 the course for the treatment of.
Compare 1 group: MAREN RUNCHANG WAN (Tongrentang Pharmaceutical Factory, Beijing TongrenTang Co., Ltd) 6g, each 1 ball, every day 2 times, within 5 days, be 1 course for the treatment of.
Compareing 2 groups: the granule taken, contain only Radix Rehmanniae, Galla Chinensis both components, remaining is identical with embodiment 3.Every day twice, early, evening each the most once, warm boiled water half an hour after meal, each take the dosage being equivalent to 45g crude drug amount.It within 5 days, it is a course for the treatment of.
Compareing 3 groups: the granule taken, contain only this kind of component of Radix Rehmanniae, remaining is identical with embodiment 3.Every day twice, early, evening each the most once, warm boiled water half an hour after meal, each take the dosage being equivalent to 45g crude drug amount.It within 5 days, it is a course for the treatment of.
4, the standard of curative effect evaluation
Therapeutic evaluation is carried out with reference to " Chinese medical disease Standardization of diagnosis and curative effect ".
Cure: transference cure, how subnormal lab testing is；
Take a turn for the better: cardinal symptom and relevant lab testing have improvement；
Do not heal: symptom and lab testing are unchanged.
5, therapeutic outcome
The comparitive study that table 1 is respectively organized
| Project | Case load | Cure number | Good revolution | Several | Cure rate | Total effective rate |
| Treat 1 group | 50 | 44 | 2 | 4 | 88% | 92% |
| Treat 2 groups | 50 | 45 | 1 | 3 | 90% | 92% |
| Treat 3 groups | 50 | 49 | 1 | 0 | 98% | 100% |
| Treat 4 groups | 50 | 49 | 0 | 1 | 98% | 98% |
| Treat 5 groups | 50 | 48 | 2 | 0 | 96% | 100% |
| Compare 1 group | 50 | 24 | 2 | 24 | 48% | 52% |
| Compare 2 groups | 50 | 11 | 3 | 36 | 22% | 28% |
| Compare 3 groups | 50 | 0 | 7 | 43 | 0% | 14% |
After the treatment of month, the curative effect of each group is as shown in table 1: the cure rate for the treatment of group is 88-98%, and total effective rate is up to more than 92%；Compared with matched group, the cure rate for the treatment of group and total effective rate are all far superior to matched group, difference statistically significant (P ＜ 0.05), illustrate that in Chinese medicine of the present invention, each component has obvious synergistic function.According to data in above table, Chinese medicine of the present invention have rapid-action, effective percentage is high, determined curative effect, safety is high, have no side effect, the simple advantage of medication；Meanwhile, the most no abnormal according to clinical observation, routine test and Function detection, and follow up a case by regular visits to 1 year, result is added up, treatment group is without recurrence, and compares 1 group of 24 example and cure patient, recurs 17 examples, relapse rate 70.8%, compare 2 group of 11 example and cure patient, recur 4 examples, relapse rate 36.4%.
6, model case
Case 1: Wei, female, 56 years old, before 5 years, it is diagnosed as constipation, once takes MAREN RUNCHANG WAN, effect is general, and frequent defecation is difficult, and constipation with dry stool, dry stool, defecation are felt the most only, and with insomnia, irritated, dreaminess.After taking 2 courses for the treatment of of granule of the embodiment of the present invention 3 preparation, cardinal symptom and relevant lab testing have improvement；After continuing to take 2 courses for the treatment of, transference cure, how subnormal lab testing is.Follow up a case by regular visits to 1 year, do not recur.
Case 2: record certain, female, 43 years old, suffer from serious constipation, and with stomachache.After taking 2 courses for the treatment of of granule of the embodiment of the present invention 3 preparation, transference cure, how subnormal lab testing is.Follow up a case by regular visits to 1 year, do not recur.
Case 3: Zhang, man, 25 years old, fatigue and asthenia, halitosis, and with having blood in stool, once took the Drug therapys such as MAREN RUNCHANG WAN, without alleviating, it is slight constipation after diagnosing.After taking 1 course for the treatment of of granule of the embodiment of the present invention 3 preparation, transference cure, how subnormal lab testing is.Follow up a case by regular visits to 1 year, do not recur.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, and without departing from the spirit or essential characteristics of the present invention, it is possible to realize the present invention in other specific forms.Therefore, no matter from the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is limited by claims rather than described above, it is intended that all changes fallen in the implication of equivalency and scope of claim included in the present invention.
In addition, it is to be understood that, although this specification is been described by according to embodiment, but the most each embodiment only comprises an independent technical scheme, this narrating mode of description is only for clarity sake, description should can also be formed, through appropriately combined, other embodiments that it will be appreciated by those skilled in the art that as an entirety, the technical scheme in each embodiment by those skilled in the art.
Claims (4)
1. the Chinese medicine treating constipation, it is characterized in that, in parts by weight, it is made up of following raw material: Radix Rehmanniae 8-15 part, Galla Chinensis 10-15 part, Aloe 28-35 part, Herba Dendrobii 18-26 part, Folium Bambusae 15-20 part, Spica Prunellae 12-15 part, Semen Cassiae 7-10 part, Mel 8-12 part.
The Chinese medicine for the treatment of constipation the most according to claim 1, it is characterized in that, in parts by weight, it is made up of following raw material: Radix Rehmanniae 10-13 part, Galla Chinensis 12-13 part, Aloe 30-33 part, Herba Dendrobii 20-24 part, Folium Bambusae 16-19 part, Spica Prunellae 13-14 part, Semen Cassiae 8-9 part, Mel 9-11 part.
The Chinese medicine for the treatment of constipation the most according to claim 1, it is characterized in that, in parts by weight, it is made up of following raw material: Radix Rehmanniae 12 parts, Galla Chinensis 13 parts, Aloe 32 parts, Herba Dendrobii 22 parts, 18 parts of Folium Bambusae, Spica Prunellae 14 parts, Semen Cassiae 9 parts, Mel 10 parts.
4. according to the preparation method of the arbitrary described Chinese medicine treating constipation of claim 1-3, it is characterised in that comprise the following steps:
(1) Radix Rehmanniae being put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 600 mesh sieves, obtains fine powder, standby；
(2) by Aloe, Herba Dendrobii, Folium Bambusae and Spica Prunellae are cleaned, pulverize with super micron mill, the ethanol solution that volumetric concentration is 50% of the 4-6 times amount immersing its quality soaks 60min, being separately immersed in volumetric concentration subsequently is 55%, 75%, 85% and 100% ethanol carries out gradient rotary evaporation eluting, then low-temperature reduced-pressure extracts 1-2h, temperature 45 C-52 DEG C, pressure 0.7-0.9MPa, reclaim ethanol, with aperture in 2000 μm, molecular cut off obtains filtrate and filtering residue at the membrane filtration of 300KDa, gained filtrate being concentrated is that at 60 DEG C, relative density is the extractum of 1.16-1.17, standby；
(3) Galla Chinensis, Semen Cassiae and Mel are cleaned, after the water of the 6-8 times amount adding its quality sum together with the filtering residue in step (2) soaks 1-2h, boiled with intense fire, slow fire boiling 3-4h, filters, obtains the first filtrate and the first filtering residue；Then the first filtering residue is added again in the water of 5-6 times amount of its quality, boiled with intense fire, slow fire boiling 2-3h, filters, obtains the second filtrate and the second filtering residue；Finally the second filtering residue is added in the water of 4-5 times amount of its quality, boiled with intense fire, slow fire boiling 1-2h, filters, obtains the 3rd filtrate and the 3rd filtering residue；Merging the first filtrate, the second filtrate and the 3rd filtrate, filter, at concentrating under reduced pressure is 60 DEG C, relative density is the thick paste of 1.23-1.24, standby；
(4) fine powder obtained by above-mentioned steps (1)-(3), extractum and thick paste are mixed, and through Co60 sterilizing, make granule, be the Chinese medicine of described treatment constipation.
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| CN105362733A (en) * | 2015-10-29 | 2016-03-02 | 陈光辉 | Drug for treating constipation |
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| CN105362733A (en) * | 2015-10-29 | 2016-03-02 | 陈光辉 | Drug for treating constipation |
| CN105582152A (en) * | 2015-12-30 | 2016-05-18 | 覃秋令 | Traditional Chinese medicine composition for treating constipation |
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