CN105999097A - 一种治疗乙肝的中药组合物 - Google Patents

一种治疗乙肝的中药组合物 Download PDF

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CN105999097A
CN105999097A CN201610534542.6A CN201610534542A CN105999097A CN 105999097 A CN105999097 A CN 105999097A CN 201610534542 A CN201610534542 A CN 201610534542A CN 105999097 A CN105999097 A CN 105999097A
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王恩禄
王芳
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Abstract

本发明涉及一种治疗乙肝的中药组合物，它包含下列重量份的物质：红牡丹20份、薏仁米10份、落地小金钱8份、降香2份、红豆根20份、黄花远志10份、虎杖8份、粉葛10份、葫芦茶10份、桑寄生10份、百合6份、栀子8份、丝瓜藤10份、鹿仙草8份、竹节黄6份、姜黄6份、威灵仙10份、田基黄8份、芦根10份、茯苓10份、藿香10份、紫苏杆10份、草果0.5份和丁香0.5份。本发明所述的中药组合物具有清热利湿、解毒除黄、化散瘀滞、疏通百脉、滋肾柔肝的效果，能够行气活血、提高免疫功能，对乙型肝炎具有显著的治疗效果。

Description

一种治疗乙肝的中药组合物
技术领域
本发明涉及医药领域，具体来说涉及一种治疗乙肝的中药组合物。
背景技术
慢性乙型肝炎(简称乙肝)是指乙肝病毒检测为阳性，病程超过半年或发病日期不明确而临床有慢性肝炎表现者。临床表现为乏力、畏食、恶心、腹胀、肝区疼痛等症状。肝大，质地为中等硬度，有轻压痛。病情重者可伴有慢性肝病面容、蜘蛛痣、肝掌、脾大，肝功能可异常或持续异常。根据临床表现分为轻度、中度和重度。而慢性乙肝携带是指乙肝病毒检测为阳性，无慢性肝炎症状，一年内连续随访三次以上血清ALT和AST均无异常，肝组织学检查正常者。
发明内容
本发明的目的是提供一种治疗乙肝的中药组合物。
为了实现本发明的目的，本发明提供一种治疗乙肝的中药组合物，它包含下列重量份的物质：红牡丹20份、薏仁米10份、落地小金钱8份、降香2份、红豆根20份、黄花远志10份、虎杖8份、粉葛10份、葫芦茶10份、桑寄生10份、百合6份、栀子8份、丝瓜藤10份、鹿仙草8份、竹节黄6份、姜黄6份、威灵仙10份、田基黄8份、芦根10份、茯苓10份、藿香10份、紫苏杆10份、草果0.5份和丁香0.5份。
优选地，本发明所述的治疗乙肝的中药组合物还包含：0.5份的具有下列结构式的物质：
更优选地，所述中药组合物可以是洗剂、软膏剂或粉剂。
本发明还提供具有下列结构式的物质在制备治疗乙肝的药物中的用途：
优选地，所述药物可以是洗剂、软膏剂或粉剂。
本发明所述的中药组合物具有清热利湿、解毒除黄、化散瘀滞、疏通百脉、滋肾柔肝的效果，能够行气活血、提高免疫功能，对乙型肝炎具有显著的治疗效果。
具体实施方式
下面通过实施例进一步说明本发明。应该理解的是，本发明的实施例是用于说明本发明而不是对本发明的限制。根据本发明的实质对本发明进行的简单改进都属于本发明要求保护的范围。除非另有说明，否则本发明中的百分数是重量百分数。
实施例1
称取红牡丹20克、薏仁米10克、落地小金钱8克、降香2克、红豆根20克、黄花远志10克、虎杖8克、粉葛10克、葫芦茶10克、桑寄生10克、百合6克、栀子8克、丝瓜藤10克、鹿仙草8克、竹节黄6克、姜黄6克、威灵仙10克、田基黄8克、芦根10克、茯苓10克、藿香10克、紫苏杆10克、草果0.5克和丁香0.5克，粉碎，过100目筛，混合均匀得到粉末。
实施例2
化合物具有下列结构式：
实验例
实验药品与试剂
实施例1中制备的粉末；实施例2的化合物；二甲基亚砜；MTT(噻唑蓝)，上海江莱生物科技有限公司；对照药品，拉米呋啶片(3TC)；葛兰素史克制药(苏州)有限公司；细胞培养基DMEM，生长液，配制，其中含10％胎牛血清，380μg/ml G418，0.03％谷胺酰胺，青霉素、链霉素各100μg/ml；
实验器材
检测乙肝表面抗原HBsAg和乙肝核心抗原HBeAg的ELISA试剂盒；孵箱；24孔板。
细胞株
Hep G2的2.2.15细胞株，教育部/卫生部医学分子病毒学重点实验室，上海。
实验方法：
取Hep G2的2.2.15细胞株，以每孔10×105个细胞接种于24孔板，在5％CO2孵箱中37℃培养，48小时后，分别将生长液换成二甲基亚砜助溶的含有实施例1的粉末和实施例2化合物的药物培养液，每组药物培养液设置5个浓度12.5μg/ml～200μg/ml，每个浓度设4个平行孔，继续培养9天，每3天换液一次。阳性对照组药物为拉米呋啶(3TC)，同时以不含药物的培养液作为空白对照组，两个对照组各设置1孔，除生长液相应的换成拉米呋啶药物与不含药物的培养液外，两对照组与药物培养液的操作相同。收集上清液用ELISA试剂盒检测HBsAg及HBeAg含量，同时用MTT测定上述两组药物不同浓度药物对细胞的毒性。其结果见下表。

Claims (5)

1.一种治疗乙肝的中药组合物，其特征在于，它包含下列重量份的物质：红牡丹20份、薏仁米10份、落地小金钱8份、降香2份、红豆根20份、黄花远志10份、虎杖8份、粉葛10份、葫芦茶10份、桑寄生10份、百合6份、栀子8份、丝瓜藤10份、鹿仙草8份、竹节黄6份、姜黄6份、威灵仙10份、田基黄8份、芦根10份、茯苓10份、藿香10份、紫苏杆10份、草果0.5份和丁香0.5份。
2.根据权利要求1所述的治疗乙肝的中药组合物，其特征在于，它还包含：0.5份的具有下列结构式的物质：
3.根据权利要求2所述的治疗乙肝的中药组合物，其特征在于，所述中药组合物可以是洗剂、软膏剂或粉剂。
4.具有下列结构式的物质在制备治疗乙肝的药物中的用途：
5.根据权利要求4所述的用途，其特征在于，所述药物可以是洗剂、软膏剂或粉剂。
CN201610534542.6A 2016-07-08 2016-07-08 一种治疗乙肝的中药组合物 Pending CN105999097A (zh)

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CN103127325A (zh) * 2013-03-25 2013-06-05 华梅 一种治疗乙肝的中药组合物及其制备方法
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CN103655935A (zh) * 2012-09-14 2014-03-26 张娅 一种治疗乙肝的中药组合物
CN105288513A (zh) * 2015-12-07 2016-02-03 包永昌 一种治疗乙肝、肝硬化的中药组合物
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WO1999032467A1 (en) * 1997-12-19 1999-07-01 Novo Nordisk A/S 1,2,4-benzothiadiazine derivatives, their preparation and use
CN101137651A (zh) * 2004-12-17 2008-03-05 安那迪斯药品股份有限公司 哒嗪酮化合物
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CN103127325A (zh) * 2013-03-25 2013-06-05 华梅 一种治疗乙肝的中药组合物及其制备方法
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CN105601586A (zh) * 2016-01-16 2016-05-25 陈洪国 一种治疗乙肝的药物组合物

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