CN105999082A - Formula applicable to patients with hepatitis liver cirrhosis at decompensated stage and accompanied hepatic encephalopathy of hepatitis liver cirrhosis - Google Patents
Formula applicable to patients with hepatitis liver cirrhosis at decompensated stage and accompanied hepatic encephalopathy of hepatitis liver cirrhosis Download PDFInfo
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- CN105999082A CN105999082A CN201610513157.3A CN201610513157A CN105999082A CN 105999082 A CN105999082 A CN 105999082A CN 201610513157 A CN201610513157 A CN 201610513157A CN 105999082 A CN105999082 A CN 105999082A
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Abstract
The invention provides a formula applicable to patients with hepatitis liver cirrhosis at a decompensated stage and accompanied hepatic encephalopathy of hepatitis liver cirrhosis. The formula is prepared from the following crude traditional Chinese medicines: arisaema with bile, rhizoma pinelliae, radix rehmanniae, radix ophiopogonis, radix et rhizoma rhei, donkey-hide gelatin, nacre mother of pearl, rhizoma acori tatarinowii, radix curcumae, spreading hedyotis herb, lophatherum herb and fried radix paeoniae alba. When the formula is clinically and actually applied, the formula has obvious curative effects of prolonging disease-free interval of patients with the hepatic encephalopathy and a severe degree in an attacking process, improving liver functions of the patients with the hepatitis liver cirrhosis (at the decompensated stage), scoring Child-pugh of the patients with the hepatitis liver cirrhosis (at the decompensated stage), and treating representations including anxiety and insomnia of the patients (metered by a Zung self-rating anxiety scale system (SAS), a Beck depression inventory (BDI) and a Pittsburgh sleep quality index inventory (PSOI); the long term prognosis of the patients with the hepatitis liver cirrhosis (at the decompensated stage) and the accompanied hepatic encephalopathy of the hepatitis liver cirrhosis can be effectively improved and a few of adverse effects are caused.
Description
Technical field
The invention belongs to pharmaceutical technology field, be specifically related to one be applicable to medical type of syndrome of hepatocirrhosis decompensated period and
The formula of concurrent hepatic encephalopathy.
Background technology
Knitting (WHO) according to world health line and estimate that hepatopathy causes that to be often close on 1000000 people dead, hepatopathy is also danger
The commonly encountered diseases frequently-occurring disease that evil our people is healthy.The existing chronic hepatitis patient of China about 30,000,000 people, because suffering from
The liver cirrhosis died whole nation has ten thousand people more than 10 every year.
The card of Chinese medical discrimination hepatic encephalopathy many genus simulataneous insufficiency and excessive, excess syndrome is that evil poison is made a psychological attack, belong to liver-wind, liver-fire,
Closing in expectorant, silt, deficiency syndrome many genus liver-yin, kidney yang, gas, blood decline de-, and gods need not.Treatment takes into account because attacking heresy
Effecting a permanent cure, heresy is anxious controls heresy, and heresy is moved back and consolidated.
Hepatic encephalopathy the most machine-processed and unclear, it is generally recognized that: 1, ammonia intoxication theory；2, false nerve is passed
Matter theory；3, Amino acid imbalance theory；4, GABA theory；5, other neural toxins are fallen ill in hepatic encephalopathy
In mechanism of action.Pathogenesis basis for hepatic encephalopathy.From pathophysiological basis, how because of hepatocyte merit
Can decline, with collateral shunting between door caval vein, the toxic product being derived from intestinal or its hetero-organization cannot be by
Liver phagocyte is removed, and is circulated by Doppler flow mapping intrusive body, and induction blood-brain barrier permeability changes,
Promote toxic product to invade brain, form disordered brain function.
Hepatic encephalopathy is one of common complication of Patients with Hepatitis Hepatocirrhosis, and frequently, mortality rate is high, patient in outbreak
Require strict low protein diet at ordinary times, report once Patients with Liver Cirrhosis Accompanied by Hepatic Encephalopathy, the then death of patient
Rate is 50%, and these all cause heavy financial burden and psychological burden to patient.Current clinical practice is
Often just treating during morbidity, and remedy measures is few, prophylactic treatment measure at ordinary times is less, so why
Sample reduces relapse rate and often becomes one of important measures improving such life in patients.
In order to solve the problems referred to above, the invention provides a kind of Chinese medicine formula, this formula uses at clinical practice
Time, it appeared that its for extend hepatic encephalopathy morbidity interval time, morbidity time the order of severity, liver
The scorching improvement of liver cirrhosis (Decompensated stage) patient's liver function, hepatitis cirrhosis (Decompensated stage) patient
Child pugh scoring, patient anxiety and insomnia performance (with ZungShi Analysisof Self-rating Anxiety Scale system (SAS),
Beck Depression scale (BDI), Pittsburgh Sleep Quality Index scale (PSQI) measure) all there are obvious curative effects, energy
Enough effectively improve hepatitis cirrhosis and concurrent hepatic encephalopathy long-term prognosis, the advantage that untoward reaction is few.
Summary of the invention
The present invention takes below scheme to realize: the present invention is according to modern theory of integrated Chinese and western medicine, through clinic
Test, uses that raw ripe medicine is reasonably combined makes.
A kind of be applicable to medical type of syndrome of hepatocirrhosis decompensated period and and the formula of its hepatic encephalopathy, by weighing as follows
The raw material of Chinese medicine medicine composition of amount part:
Arisaema Cum Bile 20-30g；Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 15-30g；Radix Rehmanniae 10-30g；Radix Ophiopogonis 10-30g；Radix Et Rhizoma Rhei 3-12g；
Colla Corii Asini 15-30g；Concha Margaritifera 30-60g；Rhizoma Acori Graminei 15-30g；Radix Curcumae 6-12g；Herba Hedyotidis Diffusae 6-12g；
Herba Lophatheri 6-10g；Radix Paeoniae Alba (parched) 5-20g.
A kind of formula being applicable to medical type of syndrome of hepatocirrhosis decompensated period and concurrent hepatic encephalopathy thereof, by weighing as follows
The raw material of Chinese medicine medicine composition of amount part:
Arisaema Cum Bile 25-30g；Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 20-30g；Radix Rehmanniae 15-30g；Radix Ophiopogonis 15-30g；Radix Et Rhizoma Rhei 6-12g；
Colla Corii Asini 20-30g；Concha Margaritifera 40-60g；Rhizoma Acori Graminei 20-30g；Radix Curcumae 8-12g；Herba Hedyotidis Diffusae 9-12g；
Herba Lophatheri 8-10g；Radix Paeoniae Alba (parched) 10-20g.
A kind of formula being applicable to medical type of syndrome of hepatocirrhosis decompensated period and concurrent hepatic encephalopathy thereof, by weighing as follows
The raw material of Chinese medicine medicine composition of amount part:
Arisaema Cum Bile 27g；Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 25g；Radix Rehmanniae 23g；Radix Ophiopogonis 25g；Radix Et Rhizoma Rhei 10g；Colla Corii Asini 25g；Precious
Pearl oyster 50g；Rhizoma Acori Graminei 25g；Radix Curcumae 10g；Herba Hedyotidis Diffusae 10g；Herba Lophatheri 8g；Radix Paeoniae Alba (parched) 15g.
Arisaema Cum Bile in the present invention: bitter cold, micro-pungent, cool, return lung, liver, spleen channel, clearing away fire and eliminating phlegm, relieving convulsion fixed
Chronic；" book on Chinese herbal medicine converge with speech ": " Rhizoma Arisaematis, forefathers with Fel Bovis seu Bubali system it, name says Arisaema Cum Bile.Fel Bovis seu Bubali bitter cold and moisten, have
The merit that the liver benefiting is relieving convulsion, star processed dry and make the most malicious."
Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens): pungent, warm；Poisonous.Return spleen, stomach, lung meridian.Function with cure mainly: stopping nausea and vomiting by lowering the adverse flow of QI.For
Vomiting regurgitation, breast gastral cavity painful abdominal mass is vexed, globus hystericus.
The Radix Rehmanniae: sweet, cold.GUIXIN, liver, kidney channel.There is clearing away heat and cooling blood, effect that tonifying YIN promotes the production of body fluid.
Radix Ophiopogonis: sweet in the mouth, micro-hardship, cold nature, return stomach, lung, heart channel, have nourishing YIN and moistening the lung, reinforcing stomach reg fluid,
Clear away heart-fire effect of relieving restlessness.
Radix Et Rhizoma Rhei: the property of medicine is bitter；Cold in nature, return through stomach；Large intestine；Liver；Spleen channel, attacks stagnant；Clearing away damp-heat；Rush down
Fire；Removing heat from blood；Blood stasis dispelling；Removing toxic substances.
Colla Corii Asini: YIN nourishing of enriching blood, moisturizes, hemostasis.
Concha Margaritifera: salty, cold.Return liver, heart channel.Suppressing the hyperactive liver and subsiding YANG；Calm the nerves arresting convulsion；Liver heat removing and eyesight improving.Concha Margaritifera
Calcium carbonate；Also containing magnesium carbonate, calcium phosphate, keratin and multiple element etc. in Pteria martensii Dunker keratin
Containing glycine, alanine, phenylalanine, leucine, serine, valine, cystine, methionine,
Arginine, histidine, tyrosine etc. more than 20 plant aminoacid.Can regulate amino acid whose unbalance.
Rhizoma Acori Graminei: removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.
Radix Curcumae: pungent, bitter, cold.Return liver, the heart, lung meridian.Promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, clear away heart-fire removing heat from blood,
Promoting the function of the gallbladder to alleviate jaundice.Shi Jinmo old Mr. likes being combined Rhizoma Acori Graminei and Radix Curcumae, two medicine one gas one blood, a Wen Yihan,
Mutually promote, clearing away phlegm circulation of qi promoting, diffusing impediment and relieving pain, brings out the best in each other.
Herba Hedyotidis Diffusae: pungent, bitter, cold.Return liver, the heart, lung meridian.Promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, clear away heart-fire
Removing heat from blood, promoting the function of the gallbladder to alleviate jaundice." Guangxi Chinese herbal medicine ": " heat-clearing and toxic substances removing, diuresis of blood circulation promoting.Treating tonsillitis, throat
Inflammation, appendicitis, hepatitis, dysentery, urinary tract infection, infantile malnutrition."
Herba Lophatheri sweet in the mouth, light, cold in nature；GUIXIN, lung, stomach, bladder warp；Body gently oozes to be let out, and has heat clearing away and removes
Tired, effect of inducing diuresis for treating stranguria syndrome.
Radix Paeoniae Alba (parched): cool, bitter, sour, be slightly cold.Return liver, spleen channel.Suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, yin fluid astringing is only
Antiperspirant.Albiflorin can ease pain with antiinflammatory, calmness, promote gastrointestinal motility effect, anti-gastric-ulcer, expansion tip
Blood vessel function, suppression blood coagulation, antioxidation, immunoregulation effect.
This Chinese medicinal formulae comprehensively can play: clearing away phlegm blood stasis dispelling, heat-clearing and toxic substances removing, suppressing the hyperactive liver to arrest the wind syndrome, yin nourishing easing the affected liver,
Benefiting vital QI and blood.We's taste are empty, and lack of appetite, abdominal distention loose stool person be cautious use of.
A kind of formula being applicable to medical type of syndrome of hepatocirrhosis decompensated period and concurrent hepatic encephalopathy thereof, its described medicine
Agent is powder, pill, tablet, electuary, capsule, oral liquid.
A kind of formula being applicable to medical type of syndrome of hepatocirrhosis decompensated period and concurrent hepatic encephalopathy thereof, according to difference
Medicine type, its preparation method is respectively as follows:
1) powder: by Arisaema Cum Bile, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), the Radix Rehmanniae, Radix Ophiopogonis, Radix Et Rhizoma Rhei, Colla Corii Asini, Concha Margaritifera, stone Chang
Pu, Radix Curcumae, Herba Hedyotidis Diffusae, Herba Lophatheri, Radix Paeoniae Alba (parched) are weighed by above-mentioned weight proportion, are dried, size-reduced
Machine is Chinese herbal medicine powder (water decoction) after pulverizing and sieving；
2) pill or tablet: by Arisaema Cum Bile, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), the Radix Rehmanniae, Radix Ophiopogonis, Radix Et Rhizoma Rhei, Colla Corii Asini, Concha Margaritifera,
Rhizoma Acori Graminei, Radix Curcumae, Herba Hedyotidis Diffusae, Herba Lophatheri, Radix Paeoniae Alba (parched) are weighed by above-mentioned weight proportion, are dried, warp
Pulverizer stirs after pulverizing and sieving and pelletizes or tabletting, dries, i.e. makes Chinese patent medicine pill or tablet；
3) electuary: by Arisaema Cum Bile, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), the Radix Rehmanniae, Radix Ophiopogonis, Radix Et Rhizoma Rhei, Colla Corii Asini, Concha Margaritifera, stone Chang
Pu, Radix Curcumae, Herba Hedyotidis Diffusae, Herba Lophatheri, Radix Paeoniae Alba (parched) are weighed by above-mentioned weight proportion, and size-reduced machine is pulverized,
Boiling, is condensed into extractum, dries, pulverizes and i.e. make Chinese patent medicine granule；
4) capsule: by Arisaema Cum Bile, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), the Radix Rehmanniae, Radix Ophiopogonis, Radix Et Rhizoma Rhei, Colla Corii Asini, Concha Margaritifera, stone Chang
Pu, Radix Curcumae, Herba Hedyotidis Diffusae, Herba Lophatheri, Radix Paeoniae Alba (parched) are weighed by above-mentioned weight proportion, and size-reduced machine is pulverized,
Boiling, is condensed into extractum, and drying, crushed filling are entered capsule and i.e. made Chinese medicine capsule；
5) oral liquid: by Arisaema Cum Bile, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), the Radix Rehmanniae, Radix Ophiopogonis, Radix Et Rhizoma Rhei, Colla Corii Asini, Concha Margaritifera, stone
Rhizoma Acori Graminei, Radix Curcumae, Herba Hedyotidis Diffusae, Herba Lophatheri, Radix Paeoniae Alba (parched) are weighed by above-mentioned weight proportion, size-reduced machine powder
Broken, boiling, it is condensed into oral liquid.
This formula is when clinical practice uses, during it appeared that it is for extending hepatic encephalopathy morbidity interval
Between, morbidity time the order of severity, the alleviation of hepatitis cirrhosis (Decompensated stage) liver function, hepatitis cirrhosis
The performance of Child-pugh scoring, patient anxiety and the insomnia of (Decompensated stage) patient is (by ZungShi anxiety certainly
Evaluation table system (SAS), Beck Depression scale (BDI), Pittsburgh Sleep Quality Index scale (PSQI) measure)
All there is obvious curative effects, it is possible to effectively improve hepatitis cirrhosis and concurrent hepatic encephalopathy long-term prognosis thereof,
The advantage that untoward reaction is few.
Detailed description of the invention
Embodiment 1
A kind of formula being applicable to medical type of syndrome of hepatocirrhosis decompensated period and concurrent hepatic encephalopathy thereof, by weighing as follows
The raw material of Chinese medicine medicine composition of amount part:
Arisaema Cum Bile 20g；Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 15g；Radix Rehmanniae 10g；Radix Ophiopogonis 10g；Radix Et Rhizoma Rhei 3g；Colla Corii Asini 15g；Precious
Pearl oyster 30g；Rhizoma Acori Graminei 15g；Radix Curcumae 6g；Herba Hedyotidis Diffusae 6g；Herba Lophatheri 6g；Radix Paeoniae Alba (parched) 5g.
A kind of formula being applicable to medical type of syndrome of hepatocirrhosis decompensated period and concurrent hepatic encephalopathy thereof, the system of powder
Preparation Method is: by Arisaema Cum Bile, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), the Radix Rehmanniae, Radix Ophiopogonis, Radix Et Rhizoma Rhei, Colla Corii Asini, Concha Margaritifera, Rhizoma Acori Graminei,
Radix Curcumae, Herba Hedyotidis Diffusae, Herba Lophatheri, Radix Paeoniae Alba (parched) are weighed by above-mentioned weight proportion, are dried, size-reduced machine powder
Broken sieve after be Chinese herbal medicine powder (water decoction).
Embodiment 2
A kind of formula being applicable to medical type of syndrome of hepatocirrhosis decompensated period and concurrent hepatic encephalopathy thereof, by weighing as follows
The raw material of Chinese medicine medicine composition of amount part:
Arisaema Cum Bile 30g；Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 30g；Radix Rehmanniae 30g；Radix Ophiopogonis 30g；Radix Et Rhizoma Rhei 12g；Colla Corii Asini 30g；Precious
Pearl oyster 60g；Rhizoma Acori Graminei 30g；Radix Curcumae 12g；Herba Hedyotidis Diffusae 12g；Herba Lophatheri 10g；Radix Paeoniae Alba (parched) 20g.
A kind of formula being applicable to medical type of syndrome of hepatocirrhosis decompensated period and concurrent hepatic encephalopathy thereof, the system of electuary
Preparation Method is respectively as follows: Arisaema Cum Bile, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), the Radix Rehmanniae, Radix Ophiopogonis, Radix Et Rhizoma Rhei, Colla Corii Asini, Concha Margaritifera, stone
Rhizoma Acori Graminei, Radix Curcumae, Herba Hedyotidis Diffusae, Herba Lophatheri, Radix Paeoniae Alba (parched) are weighed by above-mentioned weight proportion, size-reduced machine powder
Broken, boiling, it is condensed into extractum, dries, pulverize and i.e. make Chinese patent medicine granule.
Embodiment 3
A kind of formula being applicable to medical type of syndrome of hepatocirrhosis decompensated period and concurrent hepatic encephalopathy thereof, by weighing as follows
The raw material of Chinese medicine medicine composition of amount part:
Arisaema Cum Bile 27g；Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 25g；Radix Rehmanniae 23g；Radix Ophiopogonis 25g；Radix Et Rhizoma Rhei 10g；Colla Corii Asini 25g；Precious
Pearl oyster 50g；Rhizoma Acori Graminei 25g；Radix Curcumae 10g；Herba Hedyotidis Diffusae 10g；Herba Lophatheri 8g；Radix Paeoniae Alba (parched) 15g.
A kind of formula being applicable to medical type of syndrome of hepatocirrhosis decompensated period and concurrent hepatic encephalopathy thereof, pill or sheet
The preparation method of agent is respectively as follows: Arisaema Cum Bile, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), the Radix Rehmanniae, Radix Ophiopogonis, Radix Et Rhizoma Rhei, Colla Corii Asini, Margarita
Mother, Rhizoma Acori Graminei, Radix Curcumae, Herba Hedyotidis Diffusae, Herba Lophatheri, Radix Paeoniae Alba (parched) are weighed by above-mentioned weight proportion, are dried,
Size-reduced machine stirs after pulverizing and sieving and pelletizes or tabletting, dries, i.e. makes Chinese patent medicine pill or tablet.
Embodiment 4
A kind of formula being applicable to medical type of syndrome of hepatocirrhosis decompensated period and concurrent hepatic encephalopathy thereof, by weighing as follows
The raw material of Chinese medicine medicine composition of amount part:
Arisaema Cum Bile 25g；Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 25g；Radix Rehmanniae 20g；Radix Ophiopogonis 20g；Radix Et Rhizoma Rhei 8g；Colla Corii Asini 20g；Precious
Pearl oyster 50g；Rhizoma Acori Graminei 20g；Radix Curcumae 10g；Herba Hedyotidis Diffusae 10g；Herba Lophatheri 10g；Radix Paeoniae Alba (parched) 20g.
A kind of formula being applicable to medical type of syndrome of hepatocirrhosis decompensated period and concurrent hepatic encephalopathy thereof, the system of capsule
Preparation Method is respectively as follows: Arisaema Cum Bile, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), the Radix Rehmanniae, Radix Ophiopogonis, Radix Et Rhizoma Rhei, Colla Corii Asini, Concha Margaritifera, stone
Rhizoma Acori Graminei, Radix Curcumae, Herba Hedyotidis Diffusae, Herba Lophatheri, Radix Paeoniae Alba (parched) are weighed by above-mentioned weight proportion, size-reduced machine powder
Broken, boiling, it is condensed into extractum, drying, crushed filling are entered capsule and are i.e. made Chinese medicine capsule.
Embodiment 5
A kind of formula being applicable to medical type of syndrome of hepatocirrhosis decompensated period and concurrent hepatic encephalopathy thereof, by weighing as follows
The raw material of Chinese medicine medicine composition of amount part:
Arisaema Cum Bile 27g；Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 25g；Radix Rehmanniae 23g；Radix Ophiopogonis 25g；Radix Et Rhizoma Rhei 10g；Colla Corii Asini 25g；Precious
Pearl oyster 50g；Rhizoma Acori Graminei 25g；Radix Curcumae 10g；Herba Hedyotidis Diffusae 10g；Herba Lophatheri 8g；Radix Paeoniae Alba (parched) 15g.
A kind of formula being applicable to medical type of syndrome of hepatocirrhosis decompensated period and concurrent hepatic encephalopathy thereof, oral liquid
Preparation method be respectively as follows: by Arisaema Cum Bile, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), the Radix Rehmanniae, Radix Ophiopogonis, Radix Et Rhizoma Rhei, Colla Corii Asini, Concha Margaritifera,
Rhizoma Acori Graminei, Radix Curcumae, Herba Hedyotidis Diffusae, Herba Lophatheri, Radix Paeoniae Alba (parched) are weighed by above-mentioned weight proportion, size-reduced machine
Pulverize, boiling, be condensed into oral liquid.
One, partial clinical data
1.1 physical data: randomly choose case be the court during in April, 2015 in March, 2003 to, bright
Really being diagnosed as being in hospital and out-patient of the concurrent hepatic encephalopathy of posthepatitic cirrhosis, all patients are all with reference to health
Portion's " new Chinese medicine clinical guidance principle ", State Administration of Traditional Chinese Medicine's " Chinese medical disease Standardization of diagnosis and curative effect ",
GB " TCM syndrome diagnostic criteria ", China Association of Traditional Chinese Medicine's " viral hepatitis Standards of Chinese Medical Syndrome Differentiation " and the 6th
The diagnostic criteria of the version pattern of syndrome such as " Diagnostics of Chinese Medicine ", " internal medicine " teaching material.The maleest 58 examples, female 22
Example, mean age 39-65 year, I phase hepatic encephalopathy 27 example, II phase 43 example, III phase 6 example, IV phase 4
Example, patient's abdominal circumference is 89-128cm, and serum total bilirubin value is 16-45.64umol/l, Body Mass Index
19.7-26.2kg/m2, average course of disease 8.2-14.1.
1.2 exclusion standards: 1) pregnant or women breast-feeding their children；2) malignant tumor；3) chronic pancreatitis；4) tight
Double kidney function damage；5) actute infection or wound；6) long-term hormone application history；7) cerebrovascular is merged；
Totol parenteral nutrition person etc..
1.3 methods: out-patient's matched group all gives oral emulsion fructose, three times a day, a 10ML；Observe
Group uses the treatment of this Chinese medicine formula, sooner or later takes once every day, one course for the treatment of of both of which two weeks；It is in hospital and suffers from
Person gives aspartic acid ornithine 10 grams, arginase 12 0 gram, intravenous drip on the basis of out-patient, gives
Give reductive glutathione 2.4 grams, intravenous drip.Every day is the most once.General one week of the course for the treatment of.
1.4 with reference to Ministry of Public Health " new Chinese medicine clinical guidance principle ", State Administration of Traditional Chinese Medicine's " Chinese medical disease
Standardization of diagnosis and curative effect ", formulate curative effect determinate standard: the most effective: after patient treatment terminates, its mind recovers clear-headed,
Transference cure, clinical sign and symptom are significantly improved or are wholly absent, and intelligence quantitative check result shows
Normally；The most effective: after patient treatment 48h, consciousness takes a turn for the better, clinical sign and symptom be improved significantly, clinical point
Phase result substantially alleviates；The most invalid: in patient treatment 72h its disturbance of consciousness not be improved significantly or have deterioration
Trend, clinical symptoms and sign are improved inconspicuous, need to change other schemes into and treat.
1.5 statistical methods: use statistics software SPSS17.0 to be analyzed data processing, measurement data
With mean ± standard deviationRepresenting, using t inspection, enumeration data represents with percent (%), uses χ2
Inspection.
Two, part therapeutic outcome
2.1 physical data: matched group totally 40 example, wherein male 22, women 18 example, the age is mainly distributed
Between 39 years old to 65 years old, year mean age (51.2 ± 2.3), average course of disease (5.7 ± 1.21) year, body
Weight index (21.4 ± 2.3) kg/m2；I phase hepatic encephalopathy 13 example, II phase 21 example, III phase 3 example, IV
Phase 1 example.
Observation group 40 example, wherein male 21 example, women 19 example, the age is mainly distributed on 40 years old to 65 years old
Between, year mean age (50.7 ± 2.5), average course of disease (5.6 ± 1.19) year, Body Mass Index (21.7
±2.5)kg/m2；I phase hepatic encephalopathy 14 example, II phase 22 example, III phase 3 example, IV phase 3 example.
The relative analysis of the mental disorder such as anxiety and insomnia before and after 2.2 patient treatments
2.3 liang of group patient's efficacy analysis
The patient's liver function situation relative analysis of 2.4 liang of groups
2.5 liang group patient's hepatic encephalopathies morbidity interval time, morbidity time serum electrolyte situation, serious during morbidity
Degree (each phase is calculated as one point, i.e. the I phase is 1 point, and II phase was 2 points, and III phase was 3 points, and IV phase was 4 points),
Child-pugh marks improvement situation
Claims (5)
1. the formula being applicable to medical type of syndrome of hepatocirrhosis decompensated period and concurrent hepatic encephalopathy thereof, it is characterised in that
It is made up of the raw material of Chinese medicine medicine of following weight portion:
Arisaema Cum Bile 20-30g；Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 15-30g；Radix Rehmanniae 10-30g；Radix Ophiopogonis 10-30g；Radix Et Rhizoma Rhei 3-12g；
Colla Corii Asini 15-30g；Concha Margaritifera 30-60g；Rhizoma Acori Graminei 15-30g；Radix Curcumae 6-12g；Herba Hedyotidis Diffusae 6-12g；
Herba Lophatheri 6-10g；Radix Paeoniae Alba (parched) 5-20g.
One the most according to claim 1 is applicable to medical type of syndrome of hepatocirrhosis decompensated period and concurrent hepatic encephalopathy is suffered from
The formula of person, it is characterised in that be made up of the raw material of Chinese medicine medicine of following weight portion:
Arisaema Cum Bile 25-30g；Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 20-30g；Radix Rehmanniae 15-30g；Radix Ophiopogonis 15-30g；Radix Et Rhizoma Rhei 6-12g；
Colla Corii Asini 20-30g；Concha Margaritifera 40-60g；Rhizoma Acori Graminei 20-30g；Radix Curcumae 8-12g；Herba Hedyotidis Diffusae 9-12g；
Herba Lophatheri 8-10g；Radix Paeoniae Alba (parched) 10-20g.
One the most according to claim 1 is applicable to medical type of syndrome of hepatocirrhosis decompensated period and concurrent hepatic encephalopathy is suffered from
The formula of person, it is characterised in that be made up of the raw material of Chinese medicine medicine of following weight portion:
Arisaema Cum Bile 27g；Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 25g；Radix Rehmanniae 23g；Radix Ophiopogonis 25g；Radix Et Rhizoma Rhei 10g；Colla Corii Asini 25g；Precious
Pearl oyster 50g；Rhizoma Acori Graminei 25g；Radix Curcumae 10g；Herba Hedyotidis Diffusae 10g；Herba Lophatheri 8g；Radix Paeoniae Alba (parched) 15g.
One the most according to claim 1 is applicable to medical type of syndrome of hepatocirrhosis decompensated period and concurrent hepatic encephalopathy is suffered from
The formula of person, it is characterised in that described medicament is powder, pill, tablet, electuary, capsule, oral liquid.
5. the formula being applicable to medical type of syndrome of hepatocirrhosis decompensated period and concurrent hepatic encephalopathy thereof, it is characterised in that
According to different medicine types, its preparation method is respectively as follows:
1) powder: by Arisaema Cum Bile, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), the Radix Rehmanniae, Radix Ophiopogonis, Radix Et Rhizoma Rhei, Colla Corii Asini, Concha Margaritifera, stone Chang
Pu, Radix Curcumae, Herba Hedyotidis Diffusae, Herba Lophatheri, Radix Paeoniae Alba (parched) are weighed by above-mentioned weight proportion, are dried, size-reduced
Machine is Chinese herbal medicine powder (water decoction) after pulverizing and sieving；
2) pill or tablet: by Arisaema Cum Bile, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), the Radix Rehmanniae, Radix Ophiopogonis, Radix Et Rhizoma Rhei, Colla Corii Asini, Concha Margaritifera,
Rhizoma Acori Graminei, Radix Curcumae, Herba Hedyotidis Diffusae, Herba Lophatheri, Radix Paeoniae Alba (parched) are weighed by above-mentioned weight proportion, are dried, warp
Pulverizer stirs after pulverizing and sieving and pelletizes or tabletting, dries, i.e. makes Chinese patent medicine pill or tablet；
3) electuary: by Arisaema Cum Bile, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), the Radix Rehmanniae, Radix Ophiopogonis, Radix Et Rhizoma Rhei, Colla Corii Asini, Concha Margaritifera, stone Chang
Pu, Radix Curcumae, Herba Hedyotidis Diffusae, Herba Lophatheri, Radix Paeoniae Alba (parched) are weighed by above-mentioned weight proportion, and size-reduced machine is pulverized,
Boiling, is condensed into extractum, dries, pulverizes and i.e. make Chinese patent medicine granule；
4) capsule: by Arisaema Cum Bile, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), the Radix Rehmanniae, Radix Ophiopogonis, Radix Et Rhizoma Rhei, Colla Corii Asini, Concha Margaritifera, stone Chang
Pu, Radix Curcumae, Herba Hedyotidis Diffusae, Herba Lophatheri, Radix Paeoniae Alba (parched) are weighed by above-mentioned weight proportion, and size-reduced machine is pulverized,
Boiling, is condensed into extractum, and drying, crushed filling are entered capsule and i.e. made Chinese medicine capsule；
5) oral liquid: by Arisaema Cum Bile, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), the Radix Rehmanniae, Radix Ophiopogonis, Radix Et Rhizoma Rhei, Colla Corii Asini, Concha Margaritifera, stone
Rhizoma Acori Graminei, Radix Curcumae, Herba Hedyotidis Diffusae, Herba Lophatheri, Radix Paeoniae Alba (parched) are weighed by above-mentioned weight proportion, size-reduced machine powder
Broken, boiling, it is condensed into oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610513157.3A CN105999082A (en) | 2016-06-30 | 2016-06-30 | Formula applicable to patients with hepatitis liver cirrhosis at decompensated stage and accompanied hepatic encephalopathy of hepatitis liver cirrhosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610513157.3A CN105999082A (en) | 2016-06-30 | 2016-06-30 | Formula applicable to patients with hepatitis liver cirrhosis at decompensated stage and accompanied hepatic encephalopathy of hepatitis liver cirrhosis |
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| CN105999082A true CN105999082A (en) | 2016-10-12 |
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ID=57105595
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610513157.3A Pending CN105999082A (en) | 2016-06-30 | 2016-06-30 | Formula applicable to patients with hepatitis liver cirrhosis at decompensated stage and accompanied hepatic encephalopathy of hepatitis liver cirrhosis |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106579464A (en) * | 2016-11-03 | 2017-04-26 | 首都医科大学附属北京佑安医院 | Liver cirrhosis treating nutrition composition and preparation method thereof |
| CN108653676A (en) * | 2018-07-19 | 2018-10-16 | 武汉名实药业有限责任公司 | It is a kind of to be used to treat Chinese medicine composition of hepatitis and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101612360A (en) * | 2009-07-17 | 2009-12-30 | 肖嘉惠 | The medicine of treatment hepatitis, liver cirrhosis, hepatocarcinoma |
| CN104826020A (en) * | 2015-05-14 | 2015-08-12 | 奚济孝 | Traditional Chinese medicine pills for treating hepatitis complicated with liver cirrhosis ascites and preparation method |
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2016
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101612360A (en) * | 2009-07-17 | 2009-12-30 | 肖嘉惠 | The medicine of treatment hepatitis, liver cirrhosis, hepatocarcinoma |
| CN104826020A (en) * | 2015-05-14 | 2015-08-12 | 奚济孝 | Traditional Chinese medicine pills for treating hepatitis complicated with liver cirrhosis ascites and preparation method |
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| Title |
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| 雷正荣等: "《中西医结合脾胃病手册》", 31 July 2014, 四川科学技术出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106579464A (en) * | 2016-11-03 | 2017-04-26 | 首都医科大学附属北京佑安医院 | Liver cirrhosis treating nutrition composition and preparation method thereof |
| CN106579464B (en) * | 2016-11-03 | 2018-07-17 | 首都医科大学附属北京佑安医院 | A kind of alimentation composition and preparation method thereof for treating hepatic sclerosis |
| CN108653676A (en) * | 2018-07-19 | 2018-10-16 | 武汉名实药业有限责任公司 | It is a kind of to be used to treat Chinese medicine composition of hepatitis and preparation method thereof |
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Application publication date: 20161012 |