CN105998914A - Traditional Chinese medicine composition capable of treating rheumatoid arthritis - Google Patents

Traditional Chinese medicine composition capable of treating rheumatoid arthritis Download PDF

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Publication number
CN105998914A
CN105998914A CN201610557003.4A CN201610557003A CN105998914A CN 105998914 A CN105998914 A CN 105998914A CN 201610557003 A CN201610557003 A CN 201610557003A CN 105998914 A CN105998914 A CN 105998914A
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parts
radix
herba
chinese medicine
medicine composition
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刘源成
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

The invention relates to a traditional Chinese medicine composition capable of treating rheumatoid arthritis. The traditional Chinese medicine composition is prepared from the following substances in parts by weight: Chinese taxillus herbs, radix angelicae pubescentis, rhizoma corydalis, ligusticum wallichii, raw cortex eucommiae, suberect spatholobus stems, papayas, radix stephaniae tetrandrae, semen coicis, cibotium barometz, mulberry twigs, centipedes, garter snakes, clematis roots, fructus psoraleae corylifoliae, safflowers, peach kernels, cassia twigs, costus roots, radix achyranthis bidentatae, herba asari, divaricate saposhnikovia roots, cortex phellodendri, herba speranskiae tuberculatae, radix astragali, siegesbeckia herbs, gastrodia tubers, radix angelica sinensis, cortex illicii, agkistrodon acutus, ground beetles, buthus martensi karsch scorpion, pulp of dogwood fruits, ginseng, snow lotus herbs, acanthopanax bark, desertliving cistanche and aconitum carmichaeli. The traditional Chinese medicine composition disclosed by the invention has a favorable treatment effect on rheumatoid arthritis and is free from toxic and side effects.

Description

A kind of Chinese medicine composition treating rheumatoid arthritis
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of rheumatoid arthritis for the treatment of Chinese medicine composition.
Background technology
Rheumatoid arthritis be a kind of with articular synovitis be characterized chronic generalized self Immune disease.The lasting recurrent exerbation of synovitis, may result in the destruction of intraarticular cartilage and bone, Joint function disturbance, even maimed.Vasculitis pathological changes involves each organ of whole body, therefore primary disease is again It is referred to as rheumatoid disease.
Rheumatoid arthritis also known as rheumatoid (RA), is the chronic systemic that not yet understands of a kind of cause of disease Property diseases associated with inflammation, with chronic；Symmetry；Many synovial jointss are scorching is main with pathological changes outside joint Clinical manifestation, belongs to autoimmune inflammatory disease.This disease is apt to occur in hands；Wrist；The Minor articulus such as foot, Recurrent exerbation, is symmetric.There are joint red and swollen heat pain and dysfunction, advanced joint in early days May occur in which stiff deformity in various degree, and with bone and the atrophy of skeletal muscle, easily disable.
From the perspective of pathological change, rheumatoid arthritis is that one mainly involves joint cunning Articular cartilage can be fed through to after film；Osseous tissue；Articular ligament and tendon, be secondly serous coat； The heart；The popularity diseases associated with inflammation of the connective tissue such as lung and eye.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine composition treating rheumatoid arthritis.
In order to realize the purpose of the present invention, the present invention provides a kind of rheumatoid arthritis for the treatment of Chinese medicine composition, it comprises the material of following weight portion: Herba Taxilli 35-55 part, Radix Angelicae Pubescentis 35-55 Part, Rhizoma Corydalis 35-55 part, Rhizoma Chuanxiong 35-55 part, Cortex Eucommiae 35-55 part, Caulis Spatholobi 35-55 Part, Fructus Chaenomelis 35-55 part, Radix Stephaniae Tetrandrae 35-55 part, SEMEN COICIS 35-55 part, Rhizoma Cibotii 35-55 Part, Ramulus Mori 35-55 part, Scolopendra 35-55 part, Zaocys 35-55 part, Radix Clematidis 35-55 part, Fructus Psoraleae 35-55 part, Flos Carthami 35-55 part, Semen Persicae 35-55 part, Ramulus Cinnamomi 35-55 part, wood Fragrant 35-55 part, Radix Achyranthis Bidentatae 35-55 part, Herba Asari 35-55 part, Radix Saposhnikoviae 35-55 part, Cortex Phellodendri 35-55 Part, Herba speranskiae tuberculatae 35-55 part, Radix Astragali 35-55 part, Herba Siegesbeckiae 35-55 part, Rhizoma Gastrodiae 35-55 Part, Radix Angelicae Sinensis 35-55 part, Cortex schizophragmatis integrifolii radicis 35-55 part, Agkistrodon 35-55 part, Eupolyphaga Seu Steleophaga 35-55 Part, Scorpio 35-55 part, Fructus Corni 35-55 part, Radix Ginseng 35-55 part, Herba Saussureae Involueratae 35-55 Part, Cortex Acanthopancis 35-55 part, Herba Cistanches 35-55 part and Radix Aconiti Lateralis Preparata 35-55 part.
Preferably, under the Chinese medicine composition for the treatment of rheumatoid arthritis of the present invention comprises The material of row weight portion: Herba Taxilli 45 parts, Radix Angelicae Pubescentis 45 parts, Rhizoma Corydalis 45 parts, Rhizoma Chuanxiong 45 parts, Cortex Eucommiae 45 parts, Caulis Spatholobi 45 parts, Fructus Chaenomelis 45 parts, Radix Stephaniae Tetrandrae 45 parts, SEMEN COICIS 45 parts, Rhizoma Cibotii 45 parts, Ramulus Mori 45 parts, Scolopendra 45 parts, Zaocys 45 parts, Radix Clematidis 45 parts, Fructus Psoraleae 45 parts, 45 parts of Flos Carthami, 45 parts of Semen Persicae, Ramulus Cinnamomi 45 parts, the Radix Aucklandiae 45 parts, cattle 45 parts of knee joint, Herba Asari 45 parts, Radix Saposhnikoviae 45 parts, Cortex Phellodendri 45 parts, Herba speranskiae tuberculatae 45 parts, the Radix Astragali 45 parts, Herba Siegesbeckiae 45 parts, 45 parts of Rhizoma Gastrodiae, Radix Angelicae Sinensis 45 parts, Cortex schizophragmatis integrifolii radicis 45 parts, spend in vain Serpentis 45 parts, Eupolyphaga Seu Steleophaga 45 parts, Scorpio 45 parts, Fructus Corni 45 parts, Radix Ginseng 45 parts, snow 45 parts of Flos Nelumbinis, Cortex Acanthopancis 45 parts, Herba Cistanches 45 parts and Radix Aconiti Lateralis Preparata 45 parts.
It is highly preferred that the Chinese medicine composition for the treatment of rheumatoid arthritis of the present invention also wraps Contain: the material with following structural of 0.2 part:
Preferably, described Chinese medicine composition can be lotion, ointment or powder.
The present invention also provides for the material with following structural at preparation treatment rheumatoid joint The scorching purposes in medicine:
Preferably, described medicine can be lotion, ointment or powder.
Chinese medicine composition of the present invention has good curative effect to rheumatoid arthritis, nontoxic Side effect.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that the reality of the present invention Executing example is for illustrating rather than limitation of the present invention.Essence pair according to the present invention The simple modifications that the present invention is carried out broadly falls into the scope of protection of present invention.Unless otherwise saying Bright, otherwise the percent in the present invention is percetage by weight.
Embodiment 1
Weigh Herba Taxilli 45 grams, Radix Angelicae Pubescentis 45 grams, Rhizoma Corydalis 45 grams, Rhizoma Chuanxiong 45 grams, Cortex Eucommiae 45 grams, Caulis Spatholobi 45 grams, Fructus Chaenomelis 45 grams, Radix Stephaniae Tetrandrae 45 grams, SEMEN COICIS 45 grams, gold hair Rhizoma Cibotii 45 grams, Ramulus Mori 45 grams, Scolopendra 45 grams, Zaocys 45 grams, Radix Clematidis 45 grams, broken Semen Oroxyli 45 grams, 45 grams of Flos Carthami, 45 grams of Semen Persicae, Ramulus Cinnamomi 45 grams, the Radix Aucklandiae 45 grams, Radix Achyranthis Bidentatae 45 grams, Herba Asari 45 grams, Radix Saposhnikoviae 45 grams, Cortex Phellodendri 45 grams, Herba speranskiae tuberculatae 45 grams, the Radix Astragali 45 Gram, Herba Siegesbeckiae 45 grams, 45 grams of Rhizoma Gastrodiae, Radix Angelicae Sinensis 45 grams, Cortex schizophragmatis integrifolii radicis 45 grams, Agkistrodon 45 grams, Eupolyphaga Seu Steleophaga 45 grams, Scorpio 45 grams, Fructus Corni 45 grams, Radix Ginseng 45 grams, Herba Saussureae Involueratae Spend 45 grams, Cortex Acanthopancis 45 grams, Herba Cistanches 45 grams and Radix Aconiti Lateralis Preparata 45 grams, pulverize, cross 100 Mesh sieve, mix homogeneously obtains powder.
Embodiment 2
Compound has a following structural:
Experimental example
Joint type rheumatic arthritis current standard diagrams school is many, generally believes IL-4 water at present Flat relevant with the order of severity of the course of disease and disease, ill rear IL-4 level declines substantially.
Model and administration
By cleaning grade (SPF) male Wistar rat (Mus 5-6 in the age month, weight 170.0 ± 20.5) It is divided into 6 groups: Normal group (Normal control group, NC), model control group (Model Control group, MC), glucosamine matched group (Glucosamine control group, GS), administration group 1, administration group 2, administration group 3.Often group 10.In addition to Normal group, Right knee joint to remaining each group rat inject 4 weight % Papain enzyme aqueous solution 10 μ L and The Cys aqueous solution of 0.03mol/L, and strengthened respectively at the 3rd, 7 days, cause Model.Within after modeling the 14th day, starting to be administered, each group dosage is as follows: normal group and model group, Give normal saline gavage 1mL/100g body weight；Glucosamine group, glucosamine 1g Add 100mL normal saline and become suspension, give gavage 1mL/100g body weight；It is administered Group 1, the powder 10g of embodiment 1 adds 1000mL normal saline and becomes suspension, gives Gavage 1mL/100g body weight；Administration group 2, the compound of the embodiment 2 of 0.02g adds 1000mL Normal saline becomes suspension, gives gavage 1mL/100g body weight；Administration group 3, implements The compound of the embodiment 2 of powder 5g and 0.01g of example 1 adds 1000mL normal saline and joins Make suspension, give gavage 1mL/100g body weight.1 times/day, successive administration 30d, Within after modeling the 49th day, draw materials.
ELISA method detection IL-4
The 49th day by animal at after death, row ventral aorta take a blood sample, by institute's blood sampling 3000 R/min is centrifuged 5min, takes serum, puts-80 DEG C of Refrigerator stores to be measured.Concrete operation step is pressed Test kit (IL-4ELISA test kit is purchased from Mei Lian bio tech ltd, Shanghai) description Carry out.Result see table.
Group IL-4(pg·mL-1)
Normal group 133.29±3.02
Model group 45.21±1.85
Glucosamine group 88.91±2.16
Administration group 1 90.35±2.26
Administration group 2 122.18±2.82
Administration group 3 108.82±2.66

Claims (6)

1. the Chinese medicine composition treating rheumatoid arthritis, it is characterised in that its bag Material containing following weight portion: Herba Taxilli 35-55 part, Radix Angelicae Pubescentis 35-55 part, Rhizoma Corydalis 35-55 Part, Rhizoma Chuanxiong 35-55 part, Cortex Eucommiae 35-55 part, Caulis Spatholobi 35-55 part, Fructus Chaenomelis 35-55 Part, Radix Stephaniae Tetrandrae 35-55 part, SEMEN COICIS 35-55 part, Rhizoma Cibotii 35-55 part, Ramulus Mori 35-55 Part, Scolopendra 35-55 part, Zaocys 35-55 part, Radix Clematidis 35-55 part, Fructus Psoraleae 35-55 Part, Flos Carthami 35-55 part, Semen Persicae 35-55 part, Ramulus Cinnamomi 35-55 part, Radix Aucklandiae 35-55 part, Radix Achyranthis Bidentatae 35-55 part, Herba Asari 35-55 part, Radix Saposhnikoviae 35-55 part, Cortex Phellodendri 35-55 part, deep Grass 35-55 part, Radix Astragali 35-55 part, Herba Siegesbeckiae 35-55 part, Rhizoma Gastrodiae 35-55 part, Radix Angelicae Sinensis 35-55 part, Cortex schizophragmatis integrifolii radicis 35-55 part, Agkistrodon 35-55 part, Eupolyphaga Seu Steleophaga 35-55 part, Scorpio 35-55 part, Fructus Corni 35-55 part, Radix Ginseng 35-55 part, Herba Saussureae Involueratae 35-55 part, Cortex Acanthopancis 35-55 part, Herba Cistanches 35-55 part and Radix Aconiti Lateralis Preparata 35-55 part.
The Chinese medicine composition for the treatment of rheumatoid arthritis the most according to claim 1, It is characterized in that, it comprises the material of following weight portion: Herba Taxilli 45 parts, Radix Angelicae Pubescentis 45 parts, Rhizoma Corydalis 45 parts, Rhizoma Chuanxiong 45 parts, Cortex Eucommiae 45 parts, Caulis Spatholobi 45 parts, Fructus Chaenomelis 45 parts, Radix Stephaniae Tetrandrae 45 parts, SEMEN COICIS 45 parts, Rhizoma Cibotii 45 parts, Ramulus Mori 45 parts, Scolopendra 45 parts, Zaocys 45 parts, Radix Clematidis 45 parts, Fructus Psoraleae 45 parts, 45 parts of Flos Carthami, 45 parts of Semen Persicae, Ramulus Cinnamomi 45 parts, the Radix Aucklandiae 45 parts, Radix Achyranthis Bidentatae 45 parts, Herba Asari 45 parts, Radix Saposhnikoviae 45 parts, Cortex Phellodendri 45 parts, Herba speranskiae tuberculatae 45 parts, the Radix Astragali 45 parts, Herba Siegesbeckiae 45 parts, 45 parts of Rhizoma Gastrodiae, Radix Angelicae Sinensis 45 parts, Cortex schizophragmatis integrifolii radicis 45 parts, Agkistrodon 45 parts, Eupolyphaga Seu Steleophaga 45 parts, Scorpio 45 parts, mountain Fructus Corni 45 parts, Radix Ginseng 45 parts, Herba Saussureae Involueratae 45 parts, Cortex Acanthopancis 45 parts, Herba Cistanches 45 parts With Radix Aconiti Lateralis Preparata 45 parts.
The Chinese medicine composition for the treatment of rheumatoid arthritis the most according to claim 2, It is characterized in that, it also comprises: the material with following structural of 0.2 part:
The Chinese medicine composition for the treatment of rheumatoid arthritis the most according to claim 3, It is characterized in that, described Chinese medicine composition can be lotion, ointment or powder.
5. there is the material of following structural in the medicine of preparation treatment rheumatoid arthritis Purposes:
Purposes the most according to claim 5, it is characterised in that described medicine can be Lotion, ointment or powder.
CN201610557003.4A 2016-07-15 2016-07-15 Traditional Chinese medicine composition capable of treating rheumatoid arthritis Pending CN105998914A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107693743A (en) * 2017-08-31 2018-02-16 夏季 It is a kind of to treat weak medicine of muscles and bones impotence and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103656238A (en) * 2013-12-11 2014-03-26 张娟 Traditional Chinese medicine composition for treating rheumatic bone diseases
CN104173564A (en) * 2014-08-25 2014-12-03 吕红权 Traditional Chinese medicine composition for treating rheumatoid arthritis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103656238A (en) * 2013-12-11 2014-03-26 张娟 Traditional Chinese medicine composition for treating rheumatic bone diseases
CN104173564A (en) * 2014-08-25 2014-12-03 吕红权 Traditional Chinese medicine composition for treating rheumatoid arthritis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107693743A (en) * 2017-08-31 2018-02-16 夏季 It is a kind of to treat weak medicine of muscles and bones impotence and preparation method thereof

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Application publication date: 20161012