CN104606242A - Pharmaceutical composition without earthworm peculiar smell - Google Patents
Pharmaceutical composition without earthworm peculiar smell Download PDFInfo
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- CN104606242A CN104606242A CN201510096298.5A CN201510096298A CN104606242A CN 104606242 A CN104606242 A CN 104606242A CN 201510096298 A CN201510096298 A CN 201510096298A CN 104606242 A CN104606242 A CN 104606242A
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- pheretima
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Abstract
The invention provides a pharmaceutical composition without an earthworm peculiar smell. The pharmaceutical composition comprises 1 part of earthworm and more than 0.1-5 parts of milk powder according to a weight ratio. The prepared pharmaceutical composition has no earthworm peculiar smell during oral administration and high in patient compliance on the premise of keeping an original therapeutic effect of the composition.
Description
Invention field
The present invention relates to medicine, particularly a kind of pharmaceutical composition without Pheretima abnormal flavour, belong to medical art.
Background technology
Pheretima is the dry body of Annelida Ju Yin section animal Pheretima aspergillum, popular Pheretimatschiliensis, power simulation or comb the region between the heart and the diaphragm hair earthworm.There is heat clearing away arresting convulsion, dredging collateral, relieving asthma, effect of diuresis.For unconsciousness due to high fever, frightened carbuncle is twitched, and joint is benumbed, numb limbs and tense tendons, hemiplegia, dyspnea and cough due to lung-heat, edema oliguria etc.Modern study finds that Pheretima also has the effect such as antithrombotic, antitumor, immunity moderation, blood pressure lowering, arrhythmia, easing pain and diminishing inflammation.
The Chinese patent medicine containing Pheretima recorded in the national drug standards has more than 200.Prior art is containing the pharmaceutical composition of Pheretima, no matter folk prescription or compound recipe, no matter former medicated powder is used as medicine or extract formulation, the abnormal flavour of Pheretima is extra heavy, and mouthfeel is very poor, the medicine containing Pheretima is made the preparation without Pheretima abnormal flavour, can improve the compliance of patient.
Summary of the invention
The object of this invention is to provide a kind of pharmaceutical composition without Pheretima abnormal flavour.
The object of the present invention is achieved like this:
Without a pharmaceutical composition for Pheretima abnormal flavour, it is characterized in that: containing milk powder in pharmaceutical composition.
A kind of pharmaceutical composition without Pheretima abnormal flavour of the present invention, is characterized in that: Pheretima 1 part by weight, more than milk powder 0.1-5 part.
A kind of pharmaceutical composition without Pheretima abnormal flavour of the present invention, is characterized in that: Pheretima 1 part by weight, milk powder 0.5-1 part.
Pharmaceutical composition without Pheretima abnormal flavour of the present invention comprises compound recipe containing Pheretima and folk prescription, uses preparation method conventional on galenic pharmacy, the powder of preparation, decoction, granule, suspensoid and oral liquid.
Milk powder of the present invention can replace with milk, and its replacement amount is 1 ︰ 10.
So far the present invention is completed.The pharmaceutical composition containing Pheretima of preparation of the present invention, under the former medicable prerequisite of maintenance compositions, the oral abnormal flavour without Pheretima, the compliance of patient is high.
Test example is intended to further illustrate beneficial effect of the present invention below, but not restriction of the present invention.
test example one, different Pheretima pharmaceutical composition are prepared into powder mouthfeel and compare
1, different Pheretima medicinal composition powders is prepared
With a collection of Pheretima, powder will be prepared into by following material combination respectively.
1) Pheretima falls apart: Pheretima 50g, glucose 10g; Mixing, pulverizes, is distributed into 10 bags;
2) milk powder Pheretima falls apart: Pheretima 50g, glucose 10g, milk powder 5g; Mixing, pulverizes, is distributed into 10 bags.
Be made up of 10 people and appraise group through discussion, everyone Pheretima that warm water for oral use is mixed well respectively falls apart and milk powder Pheretima falls apart, and evaluates the mouthfeel mouthfeel such as " very well ", " better ", " can accept ", " poor ", " very poor ".The results are shown in Table 1.
Table 1 various combination composition powders mouthfeel compares
| Very well | Better | Can accept | Poor | Very poor | |
| Pheretima falls apart | 0 people | 0 people | 1 people | 3 people | 6 people |
| Milk powder Pheretima falls apart | 0 people | 1 people | 8 people | 1 people | 0 people |
Result shows, and compositions powder of the present invention, oral abnormal flavour is little, and mouthfeel is good.
test example two, different Pheretima medicament composition granule agent mouthfeel and the impact on rat suppository formation are compared
With a collection of Pheretima, granule will be made by following material combination respectively.
1) Pheretima granule:
Prescription: Pheretima 500g, sucrose 50g, dextrin 100g;
Method for making: get Pheretima chopping, be soaked in water 4h, decocts with water 3 times.Add the water of 10 times amount of crude drug quality for the first time, decoct 2h, second and third time respectively adds the water of 8 times amount respectively, decocts 1.5h respectively, merge 3 decoction liquor, filter, getting filtrate reduced in volume to relative density is 1.10 ~ 1.15(60 DEG C), add ethanol, just just stirring and evenly mixing is added, make alcohol content reach 70%, leave standstill 24h, filter, filtrate recycling ethanol, being evaporated to relative density is 1.25-1.28(60 DEG C), less than 60 DEG C drying under reduced pressure, add sucrose, dextrin, mixing, pulverize, granulate, dry.
2) milk powder Pheretima granule:
Prescription: Pheretima granule prescription is with milk powder 500g.
Method for making: from " get Pheretima chopping ..., less than 60 DEG C drying under reduced pressure " with Pheretima particle recipe, add milk powder, sucrose, dextrin, mixing, pulverize, granulate, dry.
1, various combination composition granule mouthfeel compares
Be made up of 10 people and appraise group through discussion, everyone is the Pheretima granule that dissolves of warm water for oral use and milk powder Pheretima granule respectively, evaluates the mouthfeel concept such as " Pheretima is highly seasoned ", " Pheretima taste is light ", " without Pheretima taste ".Evaluation result is in table 2.
Table 2 different components mouthfeel compares
| Pheretima is highly seasoned | Pheretima taste is light | Without Pheretima taste | |
| Pheretima granule | 7 people | 3 people | 0 people |
| Milk powder Pheretima granule | 0 people | 2 people | 8 people |
Result shows, and compositions of the present invention, oral Pheretima abnormal flavour is little, and mouthfeel is good.
2, the thrombotic impact of different components granules in rats
30 body weight 240 ± 30g wistar kind rats, male and female half and half, be divided into Pheretima groups of grains, milk powder Pheretima groups of grains, matched group at random, often organize 10, test group gastric infusion every day 1 time, 1 2g, matched group gavage gives equal-volume normal saline, continuous 4 days, in administration the 3rd, 4 two days, each group rat equal tail vein injection 10% high molecular dextran 2mg/kg caused blood stasis model.After last medicine 40 minutes, in left common carotid artery and right external jugular vein intubate respectively, with polyethylene pipe, two intubate are connected, 6cm long filament line is put in pipe, make blood carry out body circulation by common carotid artery to external jugular vein, after 15 minutes, take out silk thread, claim the wet weight of thrombus that silk thread is formed.The results are shown in Table 3.
The impact that table 3 different components is formed rat suppository
| Group | Dosage | Wet weight of thrombus (mg) | Suppression ratio (%) |
| Matched group | 22.16±2.74 | ||
| Pheretima groups of grains | 2g/ day | 13.14±1.77 | 40.70 |
| Milk powder Pheretima groups of grains | 2g/ day | 13.14±1.76 | 40.70 |
Result shows, Pheretima granule and milk powder Pheretima granule all have remarkable inhibition thrombosis effect, and the two effect quite.Illustrate that milk powder and Pheretima combine, maintain original curative effect.
test example three, different Pheretima pharmaceutical composition are prepared into oral liquid mouthfeel and compare hypertensive impact
With a collection of Pheretima, brain-benefiting blood pressure-reducing oral liquid will be made by following material combination respectively.
1) brain-benefiting blood pressure-reducing oral liquid:
Prescription: Pheretima 2kg, Hirudo 2kg, Radix Scutellariae 10kg, Spica Prunellae 6kg, Flos Sophorae Immaturus 6kg, Magnetitum (forging) 6kg, Radix Achyranthis Bidentatae 6kg, Radix Angelicae Sinensis 10kg, Radix Rehmanniae 4kg, Radix Salviae Miltiorrhizae 4kg, Ramulus Uncariae Cum Uncis 6kg, Semen Cassiae 10kg, Concha Margaritifera 4kg, sucrose 10kg.
Method for making: above prescription, except sucrose, decocts with water 2 times.Add the water of 10 times amount of crude drug quality for the first time, decoct 2h, second time adds the water of 8 times amount, decoct 1.5h, merge 2 decoction liquor, filter, getting filtrate reduced in volume to relative density is 1.10 ~ 1.15(60 DEG C), add ethanol, just add just stirring and evenly mixing, make alcohol content reach 70%, leave standstill 24h, filter, filtrate recycling ethanol, adds sucrose, stirs, add water to 10000ml, obtain oral liquid.
2) milk brain-benefiting blood pressure-reducing oral liquid:
Prescription: the prescription 200g with milk of brain-benefiting blood pressure-reducing oral liquid.
Method for making: from " chopping of water intaking trematodiasis ..., filtrate recycling ethanol " with compositions 1 method for making, add milk, sucrose, stir, add water to 10000ml, obtain oral liquid.
1, different material combines the brain-benefiting blood pressure-reducing oral liquid mouthfeel made and compares
Be made up of 10 people and appraise group through discussion, everyone is oral brain-benefiting blood pressure-reducing oral liquid and milk brain-benefiting blood pressure-reducing oral liquid respectively, evaluates the mouthfeel mouthfeel concept such as " stench highly seasoned ", " bad smell is light ", " without bad smell ".Evaluation result is in table 4.
Table 4 different material combination mouthfeel compares
| Stench highly seasoned | Bad smell is light | Without bad smell | |
| Brain-benefiting blood pressure-reducing oral liquid | 10 people | 0 people | 0 people |
| Milk brain-benefiting blood pressure-reducing oral liquid | 0 people | 4 people | 6 people |
Result shows, and compositions of the present invention, oral stench abnormal flavour is little, and mouthfeel is good.
2, the brain-benefiting blood pressure-reducing oral liquid that different Pheretima pharmaceutical composition is made compares hypertensive impact.
1) the routine patient of case basic condition 60 meets Evaluation of Diagnostic Criteria of Hypertension, and all has dizziness, headache, insomnia, stringy pulse, yellow fur, meets differential diagnosis in tcm liver-Yang sthenia type.Patient is divided into two groups at random, oral blood pressure lowering oral liquid 1 group 30 example, wherein man 14 example, female 16 example, age 50-75 year; Compositions 2 oral liquid group 30 example, man 15 example, female 15 example, age 50-78 year.Two groups of patient ages, the data such as sex and the course of disease, through statistical test, has comparability without significant difference.
2) Therapeutic Method
Two groups of patients oral brain-benefiting blood pressure-reducing oral liquids 1 and brain-benefiting blood pressure-reducing oral liquid 2,2 times/d, 10ml respectively/time.Take 10d as the observation period.
3) curative effect standards of grading
Recovery from illness: SBP < 140mmHg, DBP < 90mmHg, headache, dizziness waits disease disappearance; Effective: SBP < 140mmHg, DBP < 90mmHg, the diseases such as headache, dizziness alleviate; Invalid: blood pressure decline to some extent but the diseases such as dizziness, headache without improvement.
5) observation index
Observe clinical symptoms and blood pressure before and after medication
6) the results are shown in Table 5.
Table 5 liang group Clinical efficacy comparison
| Number of cases | Effective example | Effective example | Invalid example | Total effective rate (%) | |
| Oral liquid 1 | 30 | 19 | 7 | 4 | 86.67 |
| Oral liquid 2 | 30 | 20 | 6 | 4 | 86.67 |
Result shows, brain-benefiting blood pressure-reducing oral liquid and milk brain-benefiting blood pressure-reducing oral liquid all have remarkable therapeutical effect to hypertension, and the two effect quite.Illustrate that milk and Pheretima combine, maintain original curative effect.
Detailed description of the invention
embodiment 1
[prescription] Pheretima 3kg, milk powder 3kg, glucose 0.7kg, saccharin sodium 70g, vanillin 40g.
[method for making] is pulverized, and fully mixes, and is distributed into every bag of powder containing Pheretima 5g.Oral free from extraneous odour.
embodiment 2
[prescription] Pheretima 3kg, milk powder 15kg, glucose 0.7kg, saccharin sodium 10g, vanillin 5g.
[method for making] Pheretima powder is broken into coarse powder, adds 10 times of water gagings, extracts 2 times, each 1 hour, merge extractive liquid, 10 DEG C of placements are spent the night, filter, being evaporated to relative density is 1.10 ~ 1.15, drying under reduced pressure, add milk powder, glucose, saccharin sodium, vanillin, mixing, pulverizes, and granulates, drying, obtains free from extraneous odour granule.
embodiment 3
[prescription] Pheretima 3kg, milk powder 1.5kg, sucrose 0.5kg, sodium benzoate 5g.
[method for making] Pheretima powder is broken into impalpable powder, adds water to 30000ml, adds milk powder, glucose, saccharin sodium, vanillin, stirs, and obtains free from extraneous odour suspensoid.
embodiment 4
[prescription] Pheretima 22.5g, Herba Ephedrae 15g, Semen Armeniacae Amarum 15g, Radix Platycodonis 15g, Radix Peucedani 22.5g, Fructus Perillae 22.5g, Semen Raphani 22.5g, Pericarpium Citri Reticulatae 15g, Radix Aucklandiae 22.5g, Radix Curcumae 25g, Oletum Trogopterori 25g, the Radix Stemonae (processing) 22.5g, ammonium chloride 165g, Mel 3000ml, potassium sorbate 2g, milk powder 40g.
13 taste medicines more than [method for making], the Radix Aucklandiae, Herba Ephedrae, Radix Peucedani, Semen Raphani, Pericarpium Citri Reticulatae, extract volatile oil by the way of distillation, for subsequent use; Medicinal residues and the another device of aqueous solution after distilling are collected.Separately get Radix Platycodonis, the Radix Stemonae (processing), Pheretima, Semen Armeniacae Amarum, Fructus Perillae, Radix Curcumae, Oletum Trogopterori, decoct with water secondary, 2 hours first times, 2 1.5 hour, secondary decocting liquid and the aqueous solution after distilling merge, filter, filtrate reduced in volume, to about 160ml, adds ethanol and makes alcohol content reach 70%, leave standstill 48 hours, filter, decompression filtrate recycling ethanol to without alcohol taste, adds after suitable quantity of water dilutes, add ammonium chloride, volatile oil, milk powder, Mel and potassium sorbate successively, filter, add water to 10000ml, obtain the cough with asthma peace oral liquid without Pheretima abnormal flavour.
embodiment 5
[prescription] Pheretima 22.5g, Herba Ephedrae 15g, Semen Armeniacae Amarum 15g, Radix Platycodonis 15g, Radix Peucedani 22.5g, Fructus Perillae 22.5g, Semen Raphani 22.5g, Pericarpium Citri Reticulatae 15g, Radix Aucklandiae 22.5g, Radix Curcumae 25g, Oletum Trogopterori 25g, the Radix Stemonae (processing) 22.5g, ammonium chloride 165g, Mel 3000ml, potassium sorbate 2g, milk 400g.
13 taste medicines more than [method for making], the Radix Aucklandiae, Herba Ephedrae, Radix Peucedani, Semen Raphani, Pericarpium Citri Reticulatae, extract volatile oil by the way of distillation, for subsequent use; Medicinal residues and the another device of aqueous solution after distilling are collected.Separately get Radix Platycodonis, the Radix Stemonae (processing), Pheretima, Semen Armeniacae Amarum, Fructus Perillae, Radix Curcumae, Oletum Trogopterori, decoct with water secondary, 2 hours first times, the second, be 1.5 hours, secondary decocting liquid and the aqueous solution after distilling merge, filter, filtrate reduced in volume, to about 160ml, adds ethanol and makes alcohol content reach 70%, leave standstill 48 hours, filter, decompression filtrate recycling ethanol to without alcohol taste, adds after suitable quantity of water dilutes, add ammonium chloride, volatile oil, milk, Mel and potassium sorbate successively, filter, add water to 10000ml, obtain the cough with asthma peace oral liquid without Pheretima abnormal flavour.
Claims (4)
1. without a pharmaceutical composition for Pheretima abnormal flavour, it is characterized in that: containing milk powder in pharmaceutical composition.
2. a kind of pharmaceutical composition without Pheretima abnormal flavour according to claim 1, is characterized in that: Pheretima 1 part by weight, more than milk powder 0.1-5 part.
3. according to a kind of pharmaceutical composition without Pheretima abnormal flavour of claim 1 or claim 2, it is characterized in that: Pheretima 1 part by weight, milk powder 0.5-1 part.
4., according to a kind of pharmaceutical composition without Pheretima abnormal flavour of claim 1 or claim 2 or claim 3, it is characterized in that: milk powder replaces with milk, its replacement amount is 1 ︰ 10.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510096298.5A CN104606242A (en) | 2015-03-05 | 2015-03-05 | Pharmaceutical composition without earthworm peculiar smell |
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| CN201510096298.5A CN104606242A (en) | 2015-03-05 | 2015-03-05 | Pharmaceutical composition without earthworm peculiar smell |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116509980A (en) * | 2023-07-03 | 2023-08-01 | 北京盛际中医药研究院 | Traditional Chinese medicine composition for ventilating and regulating qi and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1748718A (en) * | 2005-10-20 | 2006-03-22 | 北京润德康医药技术有限公司 | Fresh earthworm preparation with the functions of calming the liver and relieving convulsion, promoting blood circulation and removing obstruction in channels and its preparing method |
| CN103891895A (en) * | 2012-12-31 | 2014-07-02 | 内蒙古伊利实业集团股份有限公司 | Liquid dairy product containing earthworm protein and preparation method of liquid dairy product |
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- 2015-03-05 CN CN201510096298.5A patent/CN104606242A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1748718A (en) * | 2005-10-20 | 2006-03-22 | 北京润德康医药技术有限公司 | Fresh earthworm preparation with the functions of calming the liver and relieving convulsion, promoting blood circulation and removing obstruction in channels and its preparing method |
| CN103891895A (en) * | 2012-12-31 | 2014-07-02 | 内蒙古伊利实业集团股份有限公司 | Liquid dairy product containing earthworm protein and preparation method of liquid dairy product |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116509980A (en) * | 2023-07-03 | 2023-08-01 | 北京盛际中医药研究院 | Traditional Chinese medicine composition for ventilating and regulating qi and preparation method and application thereof |
| CN116509980B (en) * | 2023-07-03 | 2023-10-10 | 北京盛际中医药研究院 | Traditional Chinese medicine composition for ventilating and regulating qi and preparation method and application thereof |
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Application publication date: 20150513 |