CN104622905A

CN104622905A - Medicinal composition without gecko smell

Info

Publication number: CN104622905A
Application number: CN201510096618.7A
Authority: CN
Inventors: 刘圣梅; 张为胜; 李诗标; 苏静; 许翠萍
Original assignee: Jinan Kangzhong Pharmaceutical Research and Development Co Ltd
Current assignee: Jinan Kangzhong Pharmaceutical Research and Development Co Ltd
Priority date: 2015-03-05
Filing date: 2015-03-05
Publication date: 2015-05-20

Abstract

The invention provides a medicinal composition without gecko smell. The medicinal composition comprises the following materials in parts by weight: 1 part of gecko and more than 0.1-5 parts of milk powder. The prepared medicinal composition provided by the invention has no gecko smell when being orally taken under the premise of guaranteeing the original treating effect of the composition.

Description

A kind of pharmaceutical composition without Gecko abnormal flavour

Invention field

The present invention relates to medicine, particularly a kind of pharmaceutical composition without Gecko abnormal flavour, belong to medical art.

Background technology

Gecko, has another name called celestial toad, clam Serpentis, gecko, and medicinal part is the entirety of Gekkonidae animal Gecko removing internal organs.Salty in the mouth, property is put down, and returns lung, kidney channel, has effect of invigorating the lung and the kidney, improving inspiration by invigorating kidney-QI Dingchuan, supporing yang benefit essence, is mainly used in the tachypnea for the treatment of dyspnea due to deficiency, chronic cough hemoptysis, impotence and seminal emission.Much research in recent years shows, Gecko has antitumor, relievings asthma, the effect such as gonadal hormone sample, antiinflammatory.

The Chinese patent medicine containing Gecko recorded in the national drug standards has more or less a hundred.Prior art is containing the pharmaceutical composition of Gecko, no matter folk prescription or compound recipe, no matter former medicated powder is used as medicine or extract formulation, the abnormal flavour of Gecko is extra heavy, and mouthfeel is very poor, and the medicine containing Gecko is made the preparation without Gecko abnormal flavour, necessary.

Summary of the invention

The object of this invention is to provide a kind of pharmaceutical composition without Gecko abnormal flavour.

The object of the present invention is achieved like this:

Without a pharmaceutical composition for Gecko abnormal flavour, it is characterized in that: containing milk powder in compositions.

A kind of pharmaceutical composition without Gecko abnormal flavour of the present invention, is characterized in that: milk powder dosage is Gecko 1 part by weight, more than milk powder 0.1-5 part.

A kind of pharmaceutical composition without Gecko abnormal flavour of the present invention, is characterized in that: milk powder dosage is Gecko 1 part by weight, milk powder 0.5-1 part.

Pharmaceutical composition without Gecko abnormal flavour of the present invention comprises compound recipe containing Gecko and folk prescription, uses preparation method conventional on galenic pharmacy, the powder of preparation, decoction, granule, suspensoid and oral liquid.

Milk powder of the present invention can replace with milk, and its replacement amount is 1 ︰ 10.

So far the present invention is completed.The pharmaceutical composition containing Gecko of preparation of the present invention, under the former medicable prerequisite of maintenance compositions, the oral abnormal flavour without Gecko, the compliance of patient is high.

Test example is intended to further illustrate beneficial effect of the present invention below, but not restriction of the present invention.

test example one, different Gecko pharmaceutical composition are prepared into powder mouthfeel and compare

1, different Gecko medicinal composition powders is prepared

With a collection of Gecko, powder will be prepared into by following material combination respectively.

1) Gecko falls apart: Gecko 50g, glucose 10g; Mixing, pulverizes, is distributed into 10 bags;

2) milk powder Gecko falls apart: Gecko 50g, glucose 10g, milk powder 5g, mixing, pulverizes, is distributed into 10 bags.

Be made up of 10 people and appraise group through discussion, everyone Gecko that warm water for oral use is mixed well respectively falls apart and milk powder Gecko falls apart, and evaluates the mouthfeel mouthfeel such as " very well ", " better ", " can accept ", " poor ", " very poor ".The results are shown in Table 1.

Table 1 various combination composition powders mouthfeel compares

	Very well	Better	Can accept	Poor	Very poor
						Gecko falls apart	0 people	0 people	1 people	3 people	6 people
Milk powder Gecko falls apart	0 people	1 people	8 people	1 people	0 people

Result shows, and compositions powder of the present invention, oral abnormal flavour is little, and mouthfeel is good.

test example two, different Gecko medicament composition granule agent mouthfeel and Yang-strengthening effect compare

With a collection of Gecko, granule will be made by following material combination respectively.

1) Gecko granule:

Prescription: Gecko 500g, sucrose 50g, dextrin 100g;

Method for making: get Gecko chopping, be soaked in water 4h, decocts with water three times, 3 hours first times, second time 2 hours, 1 hour third time, collecting decoction, filter, filtrate reduced in volume to relative density is 1.25-1.28(60 DEG C), less than 60 DEG C drying under reduced pressure, add sucrose, dextrin, mixing, pulverize, granulate, dry.

2) milk powder Gecko granule:

Prescription: sucrose in Gecko granule prescription is replaced with milk powder.

Method for making: with Gecko granule

1, various combination composition granule mouthfeel compares

Be made up of 10 people and appraise group through discussion, everyone is the Gecko granule that dissolves of warm water for oral use and milk powder Gecko granule respectively, evaluates the mouthfeel concept such as " Gecko is highly seasoned ", " Gecko taste is light ", " without Gecko taste ".Evaluation result is in table 2.

Table 2 different components mouthfeel compares

	Gecko is highly seasoned	Gecko taste is light	Without Gecko taste
				Gecko granule	4 people	5 people	1 people
Milk powder Gecko granule	0 people	3 people	7 people

Result shows, and compositions of the present invention, oral Gecko abnormal flavour is little, and mouthfeel is good.

2) the Gecko Yang-strengthening effect of distinct methods drying compares

SD ♂ rat 50, be divided into 5 groups at random, namely matched group gavage gives distilled water 10ml/kg, and test group respectively gavage gives Gecko granule and milk powder Gecko granule 1g/kg, adding distil water is mixed well to 10ml/kg, successive administration 30 days, after last administration 30min, puts into mouse cage separately, after adapting to 10min, put into SD ♀ Mus 1, observed and recorded ♂ Mus flutter catch ♀ Mus incubation period (first time flutter the time of catching) and 30min in flutter and catch number of times, result through statistical disposition in table 3.

Table 3 different Gecko compositions Yang-strengthening effect

	Flutter and catch incubation period (dividing)	Flutter and catch number of times (secondary/30min)
			Matched group	16.2±5.3	1.2±0.5
Milk powder Gecko groups of grains	7.7±6.5	7.4±6.8
			Gecko groups of grains	7.7±6.7	7.4±6.6

Result shows, two kinds of granule Yang-strengthening effects are suitable, illustrate that milk powder does not affect the Yang-strengthening effect of Gecko.

oral liquid mouthfeel prepared by test example three, different Gecko pharmaceutical composition and the test of rat swimming time is compared

Prescription: Radix Salviae Miltiorrhizae 125g, Radix Polygoni Multiflori 50g, Radix Codonopsis 30g, Radix Astragali 25g, Fructus Lycii 50g, Cortex Eucommiae 12.5g, Radix Angelicae Sinensis 62.5g, Rhizoma Chuanxiong 31.2g, Gecko 5.0g, Agkistrodon 66.2g, Solenognathus 15.0g.

Function cures mainly: benefiting QI and nourishing blood, nourishing the liver and kidney.Can improve QI and blood deficiency, the spiritlessness and weakness caused by deficiency of the liver and kindey, has a dizzy spell, the diseases such as soreness of the waist and knees.

Method for making:

1) oral liquid 1: above each taste decocts with water 2 times, adds the water of 10 times amount for the 1st time, decocts 2h, second time adds the water of 8 times amount, decocts 1.5h, merges 2 decoction liquor, filter, getting filtrate reduced in volume to relative density is 1.10 ~ 1.15(60 DEG C), add ethanol, just add just stirring and evenly mixing, make alcohol content reach 70%, leave standstill 24h, filter, filtrate recycling ethanol, adds cyclamate 0.4g, sorbic acid 2g, Polysorbate 8g, stir, add water to 10000ml, obtain oral liquid 1.

2) oral liquid 2: from " above each taste decocts with water 2 times .... filtrate recycling ethanol, ", with oral liquid 1, add milk 250g, cyclamate 0.4g, sorbic acid 2g, Polysorbate 8g, stir, add water to 10000ml, obtain oral liquid 2.

1, the oral liquid mouthfeel that different material compositions is made compares

Be made up of 10 people and appraise group through discussion, everyone is oral oral liquid 1 and oral liquid 2 respectively, evaluates the mouthfeel mouthfeel concept such as " stench highly seasoned ", " bad smell is light ", " without bad smell ".Evaluation result is in table 4.

Table 4 different material combination mouthfeel compares

	Stench highly seasoned	Bad smell is light	Without bad smell
				Oral liquid 1	6 people	4 people	0 people
Oral liquid 2	0 people	3 people	7 people

Result shows, oral liquid prepared by Gecko pharmaceutical composition of the present invention, and stench abnormal flavour is little.

2, the oral liquid made of different material compositions is to the test of rat swimming time

The rat of weight 300-335 g 30, is divided into 3 groups at random, often organizes 10, is respectively matched group, oral liquid 1 group, oral liquid 2 groups.Test group gavage every day gives oral liquid 5ml/kg, and matched group gavage gives equal-volume normal saline.After 14th day administration 30min, carry out exhausted movemeat test: use long 100cm, wide 50cm, the glass of high 60cm swims groove as swimming device, depth of water 50cm, 35 DEG C, water simultaneously.Measure rat to start swimming and exhaust the time used to power, power exhausts standard and sinks to not exposing for rear ten seconds water and degree of being with animal.The results are shown in Table 5.

Table 5 rats'swimming exhausted movemeat ability compares (min)

	Matched group	Oral liquid 1 group	Oral liquid 2 groups
				Power exhausts the time (min)	127.62±29.35	168.34±27.42	168.34±26.73

Result shows, oral liquid 1 and oral liquid 2 all can significantly improve the rat exhausted movemeat time, and the two effect quite.Illustrate that milk is taken after mixing with liquid and maintain original curative effect.

Detailed description of the invention

embodiment 1

[prescription] Gecko 3kg, milk powder 3kg, glucose 0.7kg, saccharin sodium 70g, vanillin 40g.

[method for making] is pulverized, and fully mixes, and is distributed into every bag of powder containing Gecko 5g.Oral free from extraneous odour.

embodiment 2

[prescription] Gecko 3kg, milk powder 15kg, glucose 0.7kg, saccharin sodium 10g, vanillin 5g.

[method for making] gecko powder is broken into coarse powder, adds 10 times of water gagings, extracts 2 times, each 1 hour, merge extractive liquid, 10 DEG C of placements are spent the night, filter, being evaporated to relative density is 1.15, drying under reduced pressure, add milk powder, glucose, saccharin sodium, vanillin, mixing, pulverizes, and granulates, drying, obtains free from extraneous odour granule.

embodiment 3

[prescription] Gecko 3kg, milk powder 1.5kg, sucrose 0.5kg, sodium benzoate 5g.

[method for making] gecko powder is broken into impalpable powder, adds water to 30000ml, adds milk powder, glucose, saccharin sodium, vanillin, stirs, and obtains free from extraneous odour suspensoid.

embodiment 4

[prescription] Cornu Cervi Pantotrichum 2g, Gecko (wine is processed) 19.5g, Penis et testis canitis (wine is processed) 9.6g, Semen Platycladi 65g, Fructus Lycii 100g, Semen pini koraiensis 50g, Rhizoma Polygonati 200g.

[method for making] above seven flavor medicine, decocts with water secondary, and first time adds 10 times of water gagings, decoct 2 hours, second time adds 8 times of water gagings, decocts 1 hour, secondary decocting liquid merges, and filter, being evaporated to relative density is 1.10, adding ethanol makes alcohol content reach 70%, leaves standstill 12 hours, filters, decompression filtrate recycling ethanol, to without alcohol taste, after adding suitable quantity of water dilution, adds milk 100ml, add water to 1000ml, obtain the oral liquid without stench abnormal flavour.For kidney yang deficiency, sexual impotence, spermatorrhea, premature ejaculation, soreness of the waist and knees, cold extremities is weak, forgetful, dynamic then diseases such as asthma.

Claims

1. without a pharmaceutical composition for Gecko abnormal flavour, it is characterized in that: containing milk powder in compositions.

2. a kind of pharmaceutical composition without Gecko abnormal flavour according to claim 1, is characterized in that: milk powder dosage is Gecko 1 part by weight, more than milk powder 0.1-5 part.

3. according to a kind of pharmaceutical composition without Gecko abnormal flavour of claim 1 or claim 2, it is characterized in that: milk powder dosage is Gecko 1 part by weight, milk powder 0.5-1 part.

4. according to claim 1 or claim 2 or claim 3 pharmaceutical composition without Gecko abnormal flavour, it is characterized in that: for the compound recipe containing Gecko and folk prescription, use preparation method conventional on galenic pharmacy, the powder of preparation, decoction, granule and oral liquid.

5. according to claim 1 or claim 2 or claim 3 one kind without the pharmaceutical composition of Gecko abnormal flavour, it is characterized in that: milk powder replaces with milk, its replacement amount is 1 ︰ 10.