CN104222520A - Feed additive for enhancing immunity of piglets - Google Patents
Feed additive for enhancing immunity of piglets Download PDFInfo
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- CN104222520A CN104222520A CN201410473117.1A CN201410473117A CN104222520A CN 104222520 A CN104222520 A CN 104222520A CN 201410473117 A CN201410473117 A CN 201410473117A CN 104222520 A CN104222520 A CN 104222520A
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Abstract
The invention provides a feed additive for enhancing the immunity of piglets. The feed additive comprises bulk drugs such as gordon euryale seeds, integripetal rhodiola herb, acanthopanax, suberect spatholobus stems, campanumoea roots, polygonatum roots, oroxyli semen, sauropus spatulifolius beille, coastal glehnia roots, giant knotweed rhizome, sedum sarmentosum bunge, potentillae chinensis herba, conyza blinii, cibotii rhizome, dregea sinensis var. corrugate, hypericum sampsonii hance, Chinese taxillus herb, rheum franzenbachii munt, herba siegesbeckiae, milfoil, ageratum aster and centellae herba. With the adoption of the feed additive, the immunity of the piglets can be significantly enhanced, the feed additive is good in effect, becomes effective quickly, can decrease the incidence and the death rate of the piglets and is safe and reliable, residues, the drug resistance and toxic and side effects do not appear easily, and the raised piglets are healthy green food.
Description
Technical field
The present invention relates to field of feed, particularly relating to a kind of feed addictive for improving pigling immunity.
Background technology
Extensively early weaned technology is adopted in modern intensive Swine Production, after piglet leaves sow, at feeding environment and nutrition flip-flop, again, under gregarious, the effect of setting up the undesirable elements such as new order of grade, easily occur with poor growth and diarrhoea for the early weaning piglet of principal character stress syndrome.Because this disease has higher incidence and the death rate, heavy losses are carried out to industrial belt of raising pigs.
At present, generally adopt in Animal husbandry production and in feed, add antibiotic, hormone, chemical synthetic drug etc. prevent and treat livestock and poultry diarrhea.October nineteen fifty antibiotic feed additive approve by Official US, U.S. feed surveillance authority (AFCO) and state food and FAD (FDA) official approval antibiotic add in feed.After this, a large amount of feeding experiments and other scientific research have been carried out in countries in the world, and antibiotic feed additive is rapidly developed, and become the important composition composition of complete feed, from then on feedstuff industry enters the antibiotic epoch.As far back as the sixties in 20th century, China just carried out research to some feeding antibiotics (as streptomysin, terramycin etc.), but for various reasons, failed to be promoted and to apply.Since the eighties, China has carried out lot of experiments and scientific research again, and feeding antibiotic starts generally to be used.At present, the nearly tens kinds of antibiotic of China's approved are as feed addictive.Antibiotic has made huge contribution as the fast development being applied as animal husbandry of feed addictive, and its result of use and the facilitation to animal husbandry are that other any one additive all cannot be compared with any one technology.
Antibiotic serves positive impetus to animal husbandry especially feed industry fast development, especially in livestock and poultry disease control and prevention and growth promotion, has played indelible effect.But along with science and technology and deepening continuously of being familiar with, people start to find drawback caused while antibiotic brings great economic benefit as feed addictive, and common cancer, deformity, the resistance to the action of a drug and some intoxicating phenomenon of human health is residual relevant with the antibiotic in meat, egg, milk, hormone and other synthetic drugs.These materials of Long-Time Service, not only easily cause pathogenic microorganism to produce the problems such as drug resistance, animal immunizing power decline and deterioration in quality, and the hazard residue in livestock products and environment can be caused to increase, human health in serious threat.
The immunity of animal body is that microorganism and harmful substance are resisted and removed to body, to keep and to recover the ability of normal physiological function.In the life process of pig, nutrition is the decisive factor maintaining function of immune system, guarantee to improve immunity.Chinese herbal medicine comes from animal, plant, mineral and products thereof, maintains nature and the biologically active of various constituent.Long-Time Service, seldom produces bacterial drug resistance, not easily occurs residual, the resistance to the action of a drug, toxic and side effect, has safety and reliability.
Chinese herbal medicine has multiple nutritional components and biologically active, has nutrition and medicament dual effect concurrently, not only can disease preventing and treating but also can improve production performance, not only can directly antibacterial and sterilization, can also regulate the immunologic function of body, have nospecific immunity antibacterial action.Chinese herbal medicine, not only containing sugar, the nutritional labeling needed for animal body such as fat, amino acid, vitamin, trace element, also contains the bioactivators such as alkaloids, glucoside, volatile oil, pigment.These bioactivators have enhancing immunity, resisting stress, adjustment metabolism, improve the effect such as meat and carcass trait.Some Chinese herbal medicine has the effect that the functional status (hyperfunction or suppression) to a certain internal organs of animal adjusts.
Weight and the Immune Function In Animals of immune organ are closely related, and Chinese herbal medicine mainly concentrates in the impact on the growth of thymus gland, spleen, lymph node, sacculus rotundus and appendix the impact of immune organ.Chinese herbal medicine can the growth of Promote immunity organ, strengthens the immunologic function of body.
At present, the use about Chinese herbal medicine is directly added after being mostly through and pulverizing, and operates more coarse, and is difficult to the quality control carrying out product, takes effect and unhappy.The invention provides a kind of novel Chinese herbal feed additive and the feed comprising this feed addictive, adopt this feed addictive can improve pigling immunity significantly, effective, instant effect, reduce piglet M & M, and not easily there is residual, the resistance to the action of a drug, toxic and side effect, have safety and reliability, the piglet raised is healthy pollution-free food.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of novel for improving the feed addictive of pigling immunity and comprising the feed of this feed addictive, adopt this feed addictive can improve pigling immunity significantly, effective, instant effect, reduce piglet M & M, and not easily there is residual, the resistance to the action of a drug, toxic and side effect, have safety and reliability, the piglet raised is healthy pollution-free food.
For solving the problems of the technologies described above, the invention provides a kind of feed addictive for improving pigling immunity, its bulk drug comprises Gorgon fruit, rhodiola root, wilsonii, reticulate millettia, Companumoea root, sealwort, Oroxylum indicum, Folium Sauropi, radix glehniae, giant knotweed, stringy stonecrop, potentilla chinensis, conyza blinii, rhizoma cibotii, passes through muscle rattan, Samson St Johswort, parasitic loranthus, franzenbach rhubarb root and rhizome, Common St.Paulswort Herb, milfoil, Aster ageratoides and centella.
Wherein, in described feed addictive, the weight portion of each bulk drug Wei Gorgon fruit 35 weight portion ~ 45 weight portion, rhodiola root 25 weight portion ~ 35 weight portion, wilsonii 35 weight portion ~ 45 weight portion, reticulate millettia 20 weight portion ~ 30 weight portion, Companumoea root 30 weight portion ~ 40 weight portion, sealwort 35 weight portion ~ 45 weight portion, Oroxylum indicum 15 weight portion ~ 25 weight portion, Folium Sauropi 15 weight portion ~ 25 weight portion, radix glehniae 25 weight portion ~ 35 weight portion, giant knotweed 30 weight portion ~ 40 weight portion, stringy stonecrop 20 weight portion ~ 30 weight portion, potentilla chinensis 15 weight portion ~ 25 weight portion, conyza blinii 25 weight portion ~ 35 weight portion, rhizoma cibotii 20 weight portion ~ 30 weight portion, pass through muscle rattan 25 weight portion ~ 35 weight portion, Samson St Johswort 30 weight portion ~ 40 weight portion, parasitic loranthus 30 weight portion ~ 40 weight portion, franzenbach rhubarb root and rhizome 25 weight portion ~ 35 weight portion, Common St.Paulswort Herb 10 weight portion ~ 20 weight portion, milfoil 20 weight portion ~ 30 weight portion, Aster ageratoides 15 weight portion ~ 25 weight portion and centella 15 weight portion ~ 25 weight portion.
Wherein, in described feed addictive, the weight portion of each bulk drug Wei Gorgon fruit 38 weight portion ~ 42 weight portion, rhodiola root 28 weight portion ~ 32 weight portion, wilsonii 38 weight portion ~ 42 weight portion, reticulate millettia 23 weight portion ~ 27 weight portion, Companumoea root 33 weight portion ~ 37 weight portion, sealwort 38 weight portion ~ 42 weight portion, Oroxylum indicum 18 weight portion ~ 22 weight portion, Folium Sauropi 18 weight portion ~ 22 weight portion, radix glehniae 28 weight portion ~ 32 weight portion, giant knotweed 33 weight portion ~ 37 weight portion, stringy stonecrop 23 weight portion ~ 27 weight portion, potentilla chinensis 18 weight portion ~ 22 weight portion, conyza blinii 28 weight portion ~ 32 weight portion, rhizoma cibotii 23 weight portion ~ 27 weight portion, pass through muscle rattan 28 weight portion ~ 32 weight portion, Samson St Johswort 33 weight portion ~ 37 weight portion, parasitic loranthus 33 weight portion ~ 37 weight portion, franzenbach rhubarb root and rhizome 28 weight portion ~ 32 weight portion, Common St.Paulswort Herb 13 weight portion ~ 17 weight portion, milfoil 23 weight portion ~ 27 weight portion, Aster ageratoides 18 weight portion ~ 22 weight portion and centella 18 weight portion ~ 22 weight portion.
Wherein, in described feed addictive, the weight portion of each bulk drug Wei Gorgon fruit 40 weight portion, rhodiola root 30 weight portion, wilsonii 40 weight portion, reticulate millettia 25 weight portion, Companumoea root 35 weight portion, sealwort 40 weight portion, Oroxylum indicum 20 weight portion, Folium Sauropi 20 weight portion, radix glehniae 30 weight portion, giant knotweed 35 weight portion, stringy stonecrop 25 weight portion, potentilla chinensis 20 weight portion, conyza blinii 30 weight portion, rhizoma cibotii 25 weight portion, pass through muscle rattan 30 weight portion, Samson St Johswort 35 weight portion, parasitic loranthus 35 weight portion, franzenbach rhubarb root and rhizome 30 weight portion, Common St.Paulswort Herb 15 weight portion, milfoil 25 weight portion, Aster ageratoides 20 weight portion and centella 20 weight portion.
Present invention also offers the preparation method of above-mentioned feed addictive, it comprises:
The first step, by Gorgon fruit, wilsonii, Companumoea root, sealwort, radix glehniae, conyza blinii, rhizoma cibotii, Samson St Johswort, parasitic loranthus, franzenbach rhubarb root and rhizome, Common St.Paulswort Herb, milfoil, Aster ageratoides and centella are pulverized respectively, mix in proportion, mixture loads in percolator, every 500g adds ethanol 800g ~ 1000g that determining alcohol is 80% ~ 90%, soak 25 hours ~ 35 hours under the condition of 35 DEG C ~ 45 DEG C, regulate percolator valve, white wine liquid is slowly oozed, the speed of oozing is 2 ~ 4mL per minute, to the color oozed is transparent, collect the drip oozed, obtain percolate, concentrated, removing white wine, dry, pulverize, obtain the first powder,
Second step, is ground into powder respectively by bulk drug component under She, sends into stirrer for mixing, obtain mixture, every 100g mixture, adds the water of 500g ~ 600g, boil 3 ~ 4 hours, filter, obtain the first filtrate, filter residue adds the water of 200g ~ 300g again, again boils 1 ~ 2 hour, filters, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, concentrated removing aqueous solvent, pulverize, dry, obtain the second dry powder;
3rd step, by the first powder and the mixing of the second powder, adds maize cob meal with the ratio of mass ratio 1: 1 subsequently, stirs, be feed addictive.
Beneficial effect of the present invention:
Provided by the invention for improving the feed addictive of pigling immunity and comprising the feed of this feed addictive, adopt this feed addictive can improve pigling immunity significantly, effective, instant effect, reduce piglet M & M, and not easily there is residual, the resistance to the action of a drug, toxic and side effect, have safety and reliability, the piglet raised is healthy pollution-free food.
Detailed description of the invention
The invention provides a kind of feed addictive for improving pigling immunity, its bulk drug comprises Gorgon fruit, rhodiola root, wilsonii, reticulate millettia, Companumoea root, sealwort, Oroxylum indicum, Folium Sauropi, radix glehniae, giant knotweed, stringy stonecrop, potentilla chinensis, conyza blinii, rhizoma cibotii, passes through muscle rattan, Samson St Johswort, parasitic loranthus, franzenbach rhubarb root and rhizome, Common St.Paulswort Herb, milfoil, Aster ageratoides and centella.
Further preferably, described feed addictive is only made up of above-mentioned raw materials medicine.
In described feed addictive, the weight portion of each bulk drug Wei Gorgon fruit 35 weight portion ~ 45 weight portion, rhodiola root 25 weight portion ~ 35 weight portion, wilsonii 35 weight portion ~ 45 weight portion, reticulate millettia 20 weight portion ~ 30 weight portion, Companumoea root 30 weight portion ~ 40 weight portion, sealwort 35 weight portion ~ 45 weight portion, Oroxylum indicum 15 weight portion ~ 25 weight portion, Folium Sauropi 15 weight portion ~ 25 weight portion, radix glehniae 25 weight portion ~ 35 weight portion, giant knotweed 30 weight portion ~ 40 weight portion, stringy stonecrop 20 weight portion ~ 30 weight portion, potentilla chinensis 15 weight portion ~ 25 weight portion, conyza blinii 25 weight portion ~ 35 weight portion, rhizoma cibotii 20 weight portion ~ 30 weight portion, pass through muscle rattan 25 weight portion ~ 35 weight portion, Samson St Johswort 30 weight portion ~ 40 weight portion, parasitic loranthus 30 weight portion ~ 40 weight portion, franzenbach rhubarb root and rhizome 25 weight portion ~ 35 weight portion, Common St.Paulswort Herb 10 weight portion ~ 20 weight portion, milfoil 20 weight portion ~ 30 weight portion, Aster ageratoides 15 weight portion ~ 25 weight portion and centella 15 weight portion ~ 25 weight portion.
Further preferably, in described feed addictive, the weight portion of each bulk drug Wei Gorgon fruit 38 weight portion ~ 42 weight portion, rhodiola root 28 weight portion ~ 32 weight portion, wilsonii 38 weight portion ~ 42 weight portion, reticulate millettia 23 weight portion ~ 27 weight portion, Companumoea root 33 weight portion ~ 37 weight portion, sealwort 38 weight portion ~ 42 weight portion, Oroxylum indicum 18 weight portion ~ 22 weight portion, Folium Sauropi 18 weight portion ~ 22 weight portion, radix glehniae 28 weight portion ~ 32 weight portion, giant knotweed 33 weight portion ~ 37 weight portion, stringy stonecrop 23 weight portion ~ 27 weight portion, potentilla chinensis 18 weight portion ~ 22 weight portion, conyza blinii 28 weight portion ~ 32 weight portion, rhizoma cibotii 23 weight portion ~ 27 weight portion, pass through muscle rattan 28 weight portion ~ 32 weight portion, Samson St Johswort 33 weight portion ~ 37 weight portion, parasitic loranthus 33 weight portion ~ 37 weight portion, franzenbach rhubarb root and rhizome 28 weight portion ~ 32 weight portion, Common St.Paulswort Herb 13 weight portion ~ 17 weight portion, milfoil 23 weight portion ~ 27 weight portion, Aster ageratoides 18 weight portion ~ 22 weight portion and centella 18 weight portion ~ 22 weight portion.
Most preferably, in described feed addictive, the weight portion of each bulk drug Wei Gorgon fruit 40 weight portion, rhodiola root 30 weight portion, wilsonii 40 weight portion, reticulate millettia 25 weight portion, Companumoea root 35 weight portion, sealwort 40 weight portion, Oroxylum indicum 20 weight portion, Folium Sauropi 20 weight portion, radix glehniae 30 weight portion, giant knotweed 35 weight portion, stringy stonecrop 25 weight portion, potentilla chinensis 20 weight portion, conyza blinii 30 weight portion, rhizoma cibotii 25 weight portion, pass through muscle rattan 30 weight portion, Samson St Johswort 35 weight portion, parasitic loranthus 35 weight portion, franzenbach rhubarb root and rhizome 30 weight portion, Common St.Paulswort Herb 15 weight portion, milfoil 25 weight portion, Aster ageratoides 20 weight portion and centella 20 weight portion.
Present invention also offers the preparation method of above-mentioned feed addictive, it comprises:
The first step, by Gorgon fruit, wilsonii, Companumoea root, sealwort, radix glehniae, conyza blinii, rhizoma cibotii, Samson St Johswort, parasitic loranthus, franzenbach rhubarb root and rhizome, Common St.Paulswort Herb, milfoil, Aster ageratoides and centella are pulverized respectively, mix in proportion, mixture loads in percolator, every 500g adds ethanol 800g ~ 1000g that determining alcohol is 80% ~ 90%, soak 25 hours ~ 35 hours under the condition of 35 DEG C ~ 45 DEG C, regulate percolator valve, white wine liquid is slowly oozed, the speed of oozing is 2 ~ 4mL per minute, to the color oozed is transparent, collect the drip oozed, obtain percolate, concentrated, removing white wine, dry, pulverize, obtain the first powder,
Second step, is ground into powder respectively by bulk drug component under She, sends into stirrer for mixing, obtain mixture, every 100g mixture, adds the water of 500g ~ 600g, boil 3 ~ 4 hours, filter, obtain the first filtrate, filter residue adds the water of 200g ~ 300g again, again boils 1 ~ 2 hour, filters, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, concentrated removing aqueous solvent, pulverize, dry, obtain the second dry powder;
3rd step, by the first powder and the mixing of the second powder, adds maize cob meal with the ratio of mass ratio 1: 1 subsequently, stirs, be medicated feed additive.
Present invention also offers a kind of feed improving pigling immunity, its raw material corn, dregs of beans, salt, fish meal, soya-bean oil, methionine, lysine, tryptophan, VitAVitE, vitamin C and the above-mentioned medicated feed additive for improving pigling immunity.
Further, described feed is only made up of above-mentioned raw materials.
Further, in described feed, the weight portion of each raw material is respectively corn 60 weight portion ~ 70 weight portion, dregs of beans 15 weight portion ~ 20 weight portion, salt 1 weight portion ~ 3 weight portion, fish meal 5 weight portion ~ 8 weight portion, soya-bean oil 8 weight portion ~ 12 weight portion, methionine 0.05 weight portion ~ 0.15 weight portion, lysine 0.05 weight portion ~ 0.15 weight portion, tryptophan 0.05 weight portion ~ 0.15 weight portion, vitamin A 0.05 weight portion ~ 0.15 weight portion, vitamin E 0.05 weight portion ~ 0.15 weight portion, vitamin C 0.05 weight portion ~ 0.15 weight portion, Chinese traditional medicine feed addictive 1 weight portion ~ 3 weight portion.
Further, in described feed, the weight portion of each raw material is respectively corn 75 weight portion, dregs of beans 18 weight portion, salt 2 weight portion, fish meal 6 weight portion, soya-bean oil 10 weight portion, methionine 0.1 weight portion, lysine 0.1 weight portion, tryptophan 0.1 weight portion, vitamin A 0.1 weight portion, vitamin E 0.1 weight portion, vitamin C 0.1 weight portion, medicated feed additive 2 weight portion.
Present invention also offers the preparation method of above-mentioned feed, comprising:
The first step, prepares described medicated feed additive;
Second step, is put into fodder mixing machine together with the described medicated feed additive that other raw material components in feedstuff and the first step are obtained, and continuous uniform stirred after 1 ~ 3 hour, put into pulverizer and pulverized, and obtains feed.
The pharmacology of each bulk drug is as follows:
Gorgon fruit: taste is sweet, puckery, property is put down.Return spleen, kidney channel.There is supplementing the kidney to control the nocturnal, tonifying spleen antidiarrheal, the function that clearing damp is only with, cure mainly emission, splenasthenic diarrhea, insufficiency of the spleen gonorrhoea, be with inferior card.
Rhodiola root: taste is sweet, bitter, property is put down, and returns lung, the heart channel of Hang-Shaoyin, has qi and activate blood circulation, effect of relievining asthma of promoting blood circulation, for qi deficiency to blood stasis, chest impediment and cardialgia, hemiplegia, the cards such as burnout asthma.
Wilsonii: be the root of studies on plants of Acanthopanax Miq. in Araliaceae wilsonii, rhizome or cauline leaf, latin name Acanthopanacis Senticosi Radix et Rhizoma seu Caulis, taste is pungent, bitter, micro-sweet, warm in nature, enter spleen, kidney, the heart channel of Hang-Shaoyin, have and replenish qi to invigorate the spleen, tonify the kidney to relieve mental strain, the effect of dispelling rheumatism, soft for wind-cold-dampness arthralgia, lumbocrural pain, muscles and bones impotence, be slow in action, the card such as body void is thin and weak, traumatic injury, fracture, oedema, beriberi, uncontrolled urination are itched.
Reticulate millettia: latin name spatholobi caulis, bitter, sweet, warm in nature, return liver, kidney channel, have hemangiectasis, enrich blood and invigorate blood circulation, menstruation regulating, the effect of stimulating the circulation of the blood and cause the muscles and joints to relax, cure mainly the irregular menstruation that the deficiency of blood has silt, limbs pain is meciless, the card such as soreness and weakness of waist and knees, pain.
Companumoea root: latin name radix campanumoea javanicae, be the root of Campanulaceae leopard platymiscium Campanumoea javanica and leopard, taste is sweet, property is put down, and returns lung, the spleen channel, has strengthening the spleen and replenishing qi, tonifies the lung to relieve cough, effect of lactogenesis, cure mainly the empty internal injury of labor, the deficiency of vital energy is weak, palpitaition, hidrosis, splenasthenic diarrhea, leukorrhea, milk is rare, the cards such as insufficiency of the spleen cough.
Sealwort: taste is sweet, property is put down, and enters lung, spleen, kidney channel, has enriching qi and yin, invigorating the spleen moistening lung, effect of enriching kidney essence, for taste deficiency of qi and yin, food is few unable, the lung-dryness syndrome due to yin deficiency, the few phlegm of dry cough, quenching one's thirst of yin asthenia generating intrinsic heat, the card such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.
Oroxylum indicum: the dry mature seed of Bignoniaceae plant oroxylum indicum, bitter, sweet, cool in nature, return lung, liver, stomach warp, have clearing lung-heat dampness removing, effect of soothing liver and harmonizing stomach, cures mainly cough with lung heat, and larynx numbness is silent, the cards such as stomachache due to emotional depression and the hyperactive liver-qi attacking the stomach.
Folium Sauropi: the dry leaf of euphorbia plant Folium Sauropi, taste is sweet, light, and property is put down, and attach to the lung and stomach meridians, have and moisten the lung and relieve the cough, effect of defaecation, cures mainly xeropulmonary cough, pharyngalgia aphonia, the cards such as constipation.
Radix glehniae: sweet, the micro-hardship of taste, cold nature, attaches to the lung and stomach meridians, and has nourishiing yin to clear away the lung-heat, and effect of reinforcing stomach reg fluid, cures mainly cough with lung heat, phthisical cough phlegm blood, deficiency of stomach-Yin, and pyreticosis Tianjin is hindered, the cards such as dry throat and mouth.
Stringy stonecrop: the dry herb of crassulaceae plants stringy stonecrop, taste is sweet, light, cool in nature, returns liver, courage, small intestinl channel, has dampness removing removing jaundice, and clearing heat and detoxicating effect, cures mainly jaundice with damp-heat pathogen, difficult urination, and carbuncle swells the cards such as sore.
Giant knotweed: latin name Polygoni Cuspidati Rhizoma et Radix, mildly bitter flavor, cold nature, return liver, courage, lung channel, have clearing heat and detoxicating, normalizing gallbladder to cure jaundice, expelling wind and removing dampness, loose stasis of blood analgesic therapy, relieving cough and reducing sputum effect, for joint pain, jaundice with damp-heat pathogen, through closing wei lump in the abdomen, coughing with a lot of sputum, scald, injury from falling down, the cards such as carbuncle sore tumefacting virus.
Potentilla chinensis: the dry herb of rosaceous plant potentilla chinensis, bitter, cold in nature, return liver, large intestine channel, have clearing heat and detoxicating, the effect removed heat from the blood and relieve diarrhea, cure mainly dysentery characterized by blood in the stool stomachache, protracted dysentery is more than, hemorrhoid hemorrhage, the cards such as carbuncle sore tumefacting virus.
Conyza blinii: be the dry aerial parts of feverfew Artemisia santonica, bitter, cold in nature, return lung, Liver Channel, there is clearing heat and eliminating phlegm, relieving cough and asthma, detoxification and promoting urination, effect of cooling blood and hemostasis, cures mainly cough with lung heat, the many asthma of phlegm, pharyngalgia, aphtha, jaundice with damp-heat pathogen, has blood in stool, uterine bleeding, the cards such as traumatism and bleeding.
Rhizoma cibotii: be the dry rhizome of Dicksoniaceae plant scythian lamb rhizome, bitter, sweet, warm in nature, return liver, kidney channel, have wines used as antirheumatic, filling liver kidney, effect of strong waist knee, cures mainly arthralgia due to wind-dampness, soreness and weakness of waist and knees, the cards such as weakness of the lower extremities.
Pass through muscle rattan: for Asclepiadaceae Wattakaka sinensis Stapf platymiscium passes through the complete stool of muscle rattan, mildly bitter flavor, property put down, have dispel the wind, dampness removing, gonorrhoea, oedema, agalactia, the cards such as exogenous injury.
Samson St Johswort: be the herb of Guttiferae hypericum Samson St Johswort, bitter, pungent, cold in nature, return liver, the spleen channel, there is removing pattogenic heat from the blood and toxic material from the body, promoting blood circulation for regulating menstruation, effect of dispelling wind and removing obstruction in the meridians, cure mainly various hemorrhage, enteritis and dysentery, acute mastitis, carbuncle swells serious case of furuncle, scalds, snake bite, irregular menstruation, dysmenorrhoea, leukorrhea, traumatic injury, arthralgia due to wind-dampness, the cards such as aphtha.
Parasitic loranthus: bitter, sweet, property is put down, and enters liver, kidney channel, have the effect of filling liver kidney, strengthening the bones and muscles, wines used as antirheumatic, antiabortive unit, for the soreness of waist pain caused by kidney deficiency and liver, muscles and bones impotence is soft, the foot and knee being feeble, kidney deficiency and liver, essence and blood void is lost, the fetal irritability of liability to be abortion, the cards such as waist abdomen pain.
Franzenbach rhubarb root and rhizome: latin name Radix et Rhizome Rhei Franzenbachii is the root and rhizome of polygonaceae plant rheum rhabarbarum, bitter; Cold in nature, return stomach; Large intestine channel, has removing toxic substances of purging heat; Effect of the cool blood stasis of blood, cures mainly jaundice with damp-heat pathogen; Dysentery; Through closing stomachache; Hematemesis and epistaxis; Fall and beat stasis of blood pain; Carbuncle swells serious case of furuncle; The erosion of mucous membrane in the oral cavity; The cards such as burn and scald.
Common St.Paulswort Herb: latin name Siegesbeckiae Herba, taste is cold, pungent, bitter, returns Liver Channel, kidney channel, has wines used as antirheumatic, sharp joint, effect of removing toxic substances, cures mainly that arthralgia due to wind-dampness, muscles and bones are unable, soreness and weakness of waist and knees, quadriplegia, hemiplegia, rubella wet the cards such as sore.
Milfoil: taste is pungent; Bitter; Property flat temperature, there is wind-expelling pain-stopping; Effect of promoting blood circulation and detoxication, cures mainly cold, fever; Head wind pain; Toothache; Arthralgia due to wind-dampness; Blood stasis is through closing; Belly lump in the abdomen; Traumatic injury; Venomous snake bite; The cards such as carbuncle sore tumefacting virus.
Aster ageratoides: bitter, pungent, cool in nature, have clearing heat and detoxicating, the effect of the cool blood that eliminates the phlegm, cures mainly cold, fever, tonsillitis, bronchitis, hepatitis, enteritis, and heat is drenched, and carbuncle swells the cards such as serious case of furuncle, snake bite and insect sting.
Centella: bitter, pungent, cool in nature, return liver, courage, urinary bladder channel, have dampness removing treating stranguria, clearing heat and detoxicating, effect of eliminating stasis to subdue swelling, cures mainly jaundice with damp-heat pathogen, and heatstroke is suffered from diarrhoea, and urolithiasis blood drenches, carbuncle sore tumefacting virus, the cards such as injury from falling down.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 medicated feed additive 1
By Gorgon fruit 40g, wilsonii 40g, Companumoea root 35g, sealwort 40g, radix glehniae 30g, conyza blinii 30g, rhizoma cibotii 25g, Samson St Johswort 35g, parasitic loranthus 35g, franzenbach rhubarb root and rhizome 30g, Common St.Paulswort Herb 15g, milfoil 25g, Aster ageratoides 20g and centella 20g pulverizes respectively, mix in proportion, mixture loads in percolator, every 500g adds the ethanol 1000g that determining alcohol is 90%, soak 30 hours under the condition of 45 DEG C, regulate percolator valve, white wine liquid is slowly oozed, the speed of oozing is 3mL per minute, to the color oozed is transparent, collect the drip oozed, obtain percolate, concentrated, removing white wine, dry, pulverize, obtain the first powder, by rhodiola root 30g, reticulate millettia 25g, Oroxylum indicum 20g, Folium Sauropi 20g, giant knotweed 35g, stringy stonecrop 25g, potentilla chinensis 20g, pass through muscle rattan 30g and be ground into powder respectively, send into stirrer for mixing, obtain mixture, every 100g mixture, add the water of 600g, boil 4 hours, filter, obtain the first filtrate, filter residue adds the water of 300g again, again boils 2 hours, filters, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, concentrated removing aqueous solvent, pulverizes, drying, obtains the second dry powder, by the first powder and the mixing of the second powder, add maize cob meal with the ratio of mass ratio 1: 1 subsequently, stir, be medicated feed additive 1.
Embodiment 2 medicated feed additive 2
By Gorgon fruit 38g, wilsonii 38g, Companumoea root 33g, sealwort 38g, radix glehniae 28g, conyza blinii 28g, rhizoma cibotii 23g, Samson St Johswort 33g, parasitic loranthus 33g, franzenbach rhubarb root and rhizome 28g, Common St.Paulswort Herb 13g, milfoil 23g, Aster ageratoides 18g and centella 18g pulverizes respectively, mix in proportion, mixture loads in percolator, every 500g adds the ethanol 1000g that determining alcohol is 90%, soak 30 hours under the condition of 45 DEG C, regulate percolator valve, white wine liquid is slowly oozed, the speed of oozing is 3mL per minute, to the color oozed is transparent, collect the drip oozed, obtain percolate, concentrated, removing white wine, dry, pulverize, obtain the first powder, by rhodiola root 28g, reticulate millettia 23g, Oroxylum indicum 18g, Folium Sauropi 18g, giant knotweed 33g, stringy stonecrop 23g, potentilla chinensis 18g, pass through muscle rattan 28g and be ground into powder respectively, send into stirrer for mixing, obtain mixture, every 100g mixture, add the water of 600g, boil 4 hours, filter, obtain the first filtrate, filter residue adds the water of 300g again, again boils 2 hours, filters, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, concentrated removing aqueous solvent, pulverizes, drying, obtains the second dry powder, by the first powder and the mixing of the second powder, add maize cob meal with the ratio of mass ratio 1: 1 subsequently, stir, be medicated feed additive 2.
Embodiment 3 medicated feed additive 3
By Gorgon fruit 42g, wilsonii 42g, Companumoea root 37g, sealwort 42g, radix glehniae 32g, conyza blinii 32g, rhizoma cibotii 27g, Samson St Johswort 37g, parasitic loranthus 37g, franzenbach rhubarb root and rhizome 32g, Common St.Paulswort Herb 17g, milfoil 27g, Aster ageratoides 22g and centella 22g pulverizes respectively, mix in proportion, mixture loads in percolator, every 500g adds the ethanol 1000g that determining alcohol is 90%, soak 30 hours under the condition of 45 DEG C, regulate percolator valve, white wine liquid is slowly oozed, the speed of oozing is 3mL per minute, to the color oozed is transparent, collect the drip oozed, obtain percolate, concentrated, removing white wine, dry, pulverize, obtain the first powder, by rhodiola root 32g, reticulate millettia 27g, Oroxylum indicum 22g, Folium Sauropi 22g, giant knotweed 37g, stringy stonecrop 27g, potentilla chinensis 22g, pass through muscle rattan 32g and be ground into powder respectively, send into stirrer for mixing, obtain mixture, every 100g mixture, add the water of 600g, boil 4 hours, filter, obtain the first filtrate, filter residue adds the water of 300g again, again boils 2 hours, filters, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, concentrated removing aqueous solvent, pulverizes, drying, obtains the second dry powder, by the first powder and the mixing of the second powder, add maize cob meal with the ratio of mass ratio 1: 1 subsequently, stir, be medicated feed additive 3.
Embodiment 4 pharmacological toxicity is tested
Acute toxicity test data
Detect reagent
Serum AST, ALT detection kit are purchased from Rui Sheng bio tech ltd, Qingdao.
Checkout equipment
Micro-200 semiautomatic biochemistry detector, assay balance, disscting instrument, syringe, test tube etc.
Test method
After the adaptability of 3 days are raised, be divided at random 3 groups (male and female half and half), often organize each 20; Control group, 2 different pharmaceutical groups (are respectively 400g/kg body weight, 300g/kg body weight), control group gavage physiological saline, the Chinese medicine composition feed addictive 1 of 2 the medicine group gavage embodiment of the present invention 1 preparations, is dissolved in Chinese medicine composition feed addictive in water and gavages mouse.
Testing index and method
(1) clinicing symptom observation: every day viewing test mouse the state of mind, diet situation, every day entry morbidity death condition.
(2) pathological observation: dead mouse is carried out cuing open inspection and observes internal organ change.
(3) growth indexes is observed: carry out routine weighing to test mouse; Off-test, slaughters that mouse weighs in, the heavy organ index of internal organs measures: cut open inspection rat, core dirty, spleen, liver, kidney, testis, ovary, weigh, calculate organ index according to the following formula: organ index=internal organs weight/body weight × 100.
(4) liver function change is observed: after off-test, slaughter mouse, take blood separation of serum, measures AST, ALT.
Data process&analysis
Each group of data all use mean soil standard deviation
represent, each group mean does test of normality and duplicate measurements homogeneity test of variance, with inspection younger between one-way analysis of variance group), P < 0.05 is for differing significantly, and P < 0.01 is difference highly significant.Statistical computation all adopts SPSS12.0 software to complete.
Clinicing symptom observation
Control group and test group mouse, the state of mind and diet wish, to external world respond have no obvious exception.Each group of mouse morbidity and death condition are as following table 1.
Table 1
| Grouping | Sum | Dead (only) | The death rate (%) |
| 1(400g/kg) | 20 | 0 | 0 |
| 2(300g/kg) | 20 | 0 | 0 |
| Control group | 20 | 0 | 0 |
Pathological observation: control group and test group, mouse carries out cuing open inspection and observes to have no and observe the obvious pathological change of internal organs after slaughtering.
Growth indexes is observed: off-test, slaughters that mouse weighs in, internal organs weight analysis is in table 2.
Table 2
| Grouping | Liver index | Cardiac index | Renal index | Lungs index | Index and spleen index |
| 1(400g/kg) | 5.79±0.22 | 0.83±0.08 | 1.23±0.21 | 0.72±0.09 | 0.51±0.06 |
| 2(300g/kg) | 5.73±0.17 | 0.80±0.11 | 1.21±0.19 | 0.74±0.12 | 0.52±0.08 |
| Control group | 5.72±0.25 | 0.82±0.09 | 1.26±0.25 | 0.73±0.10 | 0.50±0.05 |
Liver function change is observed
After off-test, slaughter mouse, take blood separation of serum, measure AST (glutamic-oxalacetic transaminease), ALT (glutamic-pyruvic transaminase) in table 3.It is not remarkable that result shows each group of data difference compared with normal healthy controls group, is all in normal range (NR).
Table 3
| Grouping | Sum | ALT | AST |
| 1(400g/kg) | 20 | 30.91±2.17 | 132.11±10.32 |
| 2(300g/kg) | 20 | 32.63±2.53 | 130.57±9.96 |
| Control group | 20 | 31.97±2.09 | 131.91±12.03 |
Long term toxicity test data
Chinese medicine composition feed addictive 20g/kg, 100g/kg of the present invention of preparing according to embodiment 1 were to the continuous gastric infusion of rat 3 months, the fur of animal, the colour of skin, ingest, activity, the blood parameters such as routine blood test, Liver and kidney function of the animal all without exception such as urine, feces and animal main organs index all in normal range (NR), and normal kinetic indifference histopathologic examination shows, the important organs such as the heart, liver, spleen, lung, kidney, adrenal gland, tracheae, testis, ovary are without pathological change.Drug withdrawal checks above indices all without overt toxicity reaction after two weeks, show without cumulative toxicity.
Acute toxicity test data
Detect reagent
Serum AST, ALT detection kit are purchased from Rui Sheng bio tech ltd, Qingdao.
Checkout equipment
Micro-200 semiautomatic biochemistry detector, assay balance, disscting instrument, syringe, test tube etc.
Test method
After the adaptability of 3 days are raised, be divided at random 3 groups (male and female half and half), often organize each 20; Control group, 2 different pharmaceutical groups (are respectively 400g/kg body weight, 300g/kg body weight), control group gavage physiological saline, the medicated feed additive 1 of 2 the medicine group gavage embodiment of the present invention 1 preparations, is dissolved in Chinese medicine composition feed addictive in water and gavages mouse.
Testing index and method
(1) clinicing symptom observation: every day viewing test mouse the state of mind, diet situation, every day entry morbidity death condition.
(2) pathological observation: dead mouse is carried out cuing open inspection and observes internal organ change.
(3) growth indexes is observed: carry out routine weighing to test mouse; Off-test, slaughters that mouse weighs in, the heavy organ index of internal organs measures: cut open inspection rat, core dirty, spleen, liver, kidney, testis, ovary, weigh, calculate organ index according to the following formula: organ index=internal organs weight/body weight × 100.
(4) liver function change is observed: after off-test, slaughter mouse, take blood separation of serum, measures AST, ALT.
Data process&analysis
Each group of data all use mean soil standard deviation
represent, each group mean does test of normality and duplicate measurements homogeneity test of variance, with inspection younger between one-way analysis of variance group), P < 0.05 is for differing significantly, and P < 0.01 is difference highly significant.Statistical computation all adopts SPSS12.0 software to complete.
Clinicing symptom observation
Control group and test group mouse, the state of mind and diet wish, to external world respond have no obvious exception.Each group of mouse morbidity and death condition are as following table 1.
Table 1
| Grouping | Sum | Dead (only) | The death rate (%) |
| 1(400g/kg) | 20 | 0 | 0 |
| 2(300g/kg) | 20 | 0 | 0 |
| Control group | 20 | 0 | 0 |
Pathological observation: control group and test group, mouse carries out cuing open inspection and observes to have no and observe the obvious pathological change of internal organs after slaughtering.
Growth indexes is observed: off-test, slaughters that mouse weighs in, internal organs weight analysis is in table 2.
Table 2
| Grouping | Liver index | Cardiac index | Renal index | Lungs index | Index and spleen index |
| 1(400g/kg) | 5.61±0.17 | 0.80±0.09 | 1.20±0.19 | 0.73±0.11 | 0.50±0.03 |
| 2(300g/kg) | 5.65±0.31 | 0.81±0.13 | 1.22±0.26 | 0.68±0.09 | 0.51±0.05 |
| Control group | 5.63±0.22 | 0.78±0.06 | 1.23±0.21 | 0.70±0.21 | 0.48±0.03 |
Liver function change is observed
After off-test, slaughter mouse, take blood separation of serum, measure AST (glutamic-oxalacetic transaminease), ALT (glutamic-pyruvic transaminase) in table 3.It is not remarkable that result shows each group of data difference compared with normal healthy controls group, is all in normal range (NR).
Table 3
| Grouping | Sum | ALT | AST |
| 1(400g/kg) | 20 | 30.61±1.36 | 130.62±8.29 |
| 2(300g/kg) | 20 | 31.03±1.99 | 131.27±7.26 |
| Control group | 20 | 30.23±1.76 | 130.27±9.23 |
Long term toxicity test data
Chinese medicine composition feed addictive 20g/kg, 100g/kg of the present invention of preparing according to embodiment 1 were to the continuous gastric infusion of rat 3 months, the fur of animal, the colour of skin, ingest, activity, the blood parameters such as routine blood test, Liver and kidney function of the animal all without exception such as urine, feces and animal main organs index all in normal range (NR), and normal kinetic indifference histopathologic examination shows, the important organs such as the heart, liver, spleen, lung, kidney, adrenal gland, tracheae, testis, ovary are without pathological change.Drug withdrawal checks above indices all without overt toxicity reaction after two weeks, show without cumulative toxicity.
Embodiment 5 feed 1
Corn 7.5kg, dregs of beans 1.8kg, salt 0.2kg, fish meal 0.6kg, soya-bean oil 1kg, methionine 0.01kg, lysine 0.01kg, tryptophan 0.01kg, vitamin A 0.01kg, vitamin E 0.01kg, vitamin C 0.01kg, 0.2kg medicated feed additive 1 are put into fodder mixing machine together, after continuous uniform stirs 3 hours, put into pulverizer to pulverize, obtain feed 1.
Comparative example 1 feed 2
Corn 7.5kg, dregs of beans 1.8kg, salt 0.2kg, fish meal 0.6kg, soya-bean oil 1kg, methionine 0.01kg, lysine 0.01kg, tryptophan 0.01kg, vitamin A 0.01kg, vitamin E 0.01kg, vitamin C 0.01kg are put into fodder mixing machine together, after continuous uniform stirs 3 hours, put into pulverizer to pulverize, obtain feed 2.
Immunity effect test
Reagent and instrument
Sheep red blood cell (SRBC) suspension, liquaemin, Hank ' s liquid, Ficoll (GE Healthcare), RPMI1640, MTT liquid, PBS, SDS liquid, microscope CX31-32C02 (Olympus), electronic balance BT125D (Sai Duolisi), centrifuge 2-16p (Sigma), CO
2incubator C150 (Binder), ultraviolet-uisible spectrophotometer UV-1240 (Shimadzu).
Animal experiment designs
Experimental animal be 300 28 age in days Duroc × length of identical rearing conditions white × Dasanyuan hybridization piglet, original body mass is close, and group difference is not remarkable.Be divided into 3 groups at random, the feed 1 of test group feeding embodiment 5 preparation, contrast 1 group only feeding comparative example 1 prepare feed 2, contrast feed 2 prepared by 2 groups of feeding comparative examples 1, add Conventional antibiotic and chemicals in feed.All piglets injected 5mL1.0% sheep red blood cell (SRBC) suspension through ear vein, experimental period 14d in 28 ages in days the same day.
Feeding and management
Pig house, rearing conditions, hygienic conditions, feed quality and other feedings and managements etc. are all identical, free choice feeding and drinking-water.
Blood specimen collection
Three modes of taking a blood sample are taked in blood specimen collection, before namely testing, after test 7d, after test 14d.Blood sampling time: early morning on an empty stomach.A small amount of through ear vein blood sampling from 3 groups of live bodies respectively, through jugular vein blood collection 8 ~ 10mL (adding 1% liquaemin anti-freezing).
Test item and method
The mensuration of neutrophil leucocyte and PBLC percentage
Ear vein blood carries out conventional Arneth's count.
The mensuration of sheep red blood cell (SRBC) antibody titer
The conventional micromethod hemagglutination test of ear vein blood measures piglet sheep red blood cell (SRBC) antibody titer (sheep red blood cell (SRBC) concentration is 1.0%).
The mensuration of gamma globulin content
Ear vein blood separation of serum, each protein component in cellulose acetate membrane electrophoresis method separation of serum, after dyeing, wash-out, on spectrophotometer, 620nm measures OD value, surveys gamma globulin relative amount.
The mensuration of mononuclear cell proliferation rate in peripheral blood
After the dilution of liquaemin anticoagulated blood Hank ' s liquid, add Ficoll parting liquid (GE Healthcare), 2000r/min horizontal centrifugal 30min.Careful absorption mononuclearcell boundary layer, Hank ' s liquid washs 2 times, with RPMI1640 complete culture solution adjustment cell concentration for 2 × 10
6/ mL, add 40 hole steril cell culture plates, every hole adds cell suspension 0.1mL, and adds containing or do not contain the RPMI1640 complete culture solution (final concentration 10 μ g/mL) of PHA, and transform or spontaneous nuclear transformation contrast to do to stimulate, every increment product add 3 holes.Put 37 DEG C, 5%CO
266h cultivated by incubator, then adds MTT liquid (PBS prepares, pH7.2) and makes its final concentration be 0.5mg/mL.Continue to cultivate 6h, then add 20%SDS liquid (containing 50% dimethylformamide, pH4.7), 37 DEG C of effect 12h, on spectrophotometer, 570nm place surveys OD value.
Data processing
Measurement data adopts
represent, compare between group and adopt χ
2inspection, all data all adopt the process of SPSS12.0 statistical software.
Result
Medicated feed additive, on the impact of piglet neutrophil leucocyte and PBLC percentage, the results are shown in Table 1.
Table 1 is on the impact/% of piglet neutrophil leucocyte and PBLC percentage
As can be seen from Table 1, adopting medicated feed additive provided by the invention can significantly improve neutrophil leucocyte in piglet blood system significantly increases, and lymphocyte significantly declines, than antibiotic and chemical drugs better effects if.
Medicated feed additive, on the impact of piglet sheep red blood cell (SRBC) antibody titer, the results are shown in Table 2.
Table 2 is on the impact of piglet serum sheep red blood cell (SRBC) antibody titer (log2)
| Test period/d | Contrast 1 group | Contrast 2 groups | Test group |
| 0 | 0.19±0.004 | 0.20±0.002 | 0.19±0.002 |
| 7 | 4.49±0.051 | 3.53±0.052 | 4.39±0.037 |
| 14 | 4.53±0.047 | 4.10±0.061 | 5.57±0.049 |
Result of the test shows, adopts medicated feed additive provided by the invention can significantly improve the immune response of piglet.
Medicated feed additive, on the impact of piglet gamma globulin content (OD value), the results are shown in Table 3.
Table 3 is on the impact of piglet gamma globulin content (OD value)
| Test period/d | Contrast 1 group | Contrast 2 groups | Test group |
| 0 | 23.17±0.16 | 23.11±0.32 | 23.52±0.40 |
| 7 | 23.05±0.63 | 22.61±0.19 | 23.06±0.51 |
| 14 | 23.23±0.22 | 22.96±0.39 | 24.92±0.33 |
Result of the test shows, adopts medicated feed additive provided by the invention to strengthen pigling immunity.
Medicated feed additive, on the impact of mononuclear cell proliferation rate in piglet peripheral blood (OD value), the results are shown in Table 4.
Table 4 is on the impact of mononuclear cell proliferation rate in piglet peripheral blood (OD value)
| Test period/d | Contrast 1 group | Contrast 2 groups | Test group |
| 0 | 0.58±0.0013 | 0.59±0.0011 | 0.59±0.0012 |
| 7 | 0.56±0.0021 | 0.36±0.0015 | 0.55±0.0023 |
| 14 | 0.52±0.0016 | 0.39±0.0020 | 0.53±0.0022 |
Result of the test is known, adopts traditional chemical drugs and antibiotic to significantly reduce PMBC appreciation rate, test group PMBC appreciation rate with contrast 1 group without marked difference.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (5)
1. for improving a feed addictive for pigling immunity, it is characterized in that: bulk drug comprises Gorgon fruit, rhodiola root, wilsonii, reticulate millettia, Companumoea root, sealwort, Oroxylum indicum, Folium Sauropi, radix glehniae, giant knotweed, stringy stonecrop, potentilla chinensis, conyza blinii, rhizoma cibotii, passes through muscle rattan, Samson St Johswort, parasitic loranthus, franzenbach rhubarb root and rhizome, Common St.Paulswort Herb, milfoil, Aster ageratoides and centella.
2. feed addictive as claimed in claim 1, is characterized in that: the weight portion of each bulk drug Wei Gorgon fruit 35 weight portion ~ 45 weight portion, rhodiola root 25 weight portion ~ 35 weight portion, wilsonii 35 weight portion ~ 45 weight portion, reticulate millettia 20 weight portion ~ 30 weight portion, Companumoea root 30 weight portion ~ 40 weight portion, sealwort 35 weight portion ~ 45 weight portion, Oroxylum indicum 15 weight portion ~ 25 weight portion, Folium Sauropi 15 weight portion ~ 25 weight portion, radix glehniae 25 weight portion ~ 35 weight portion, giant knotweed 30 weight portion ~ 40 weight portion, stringy stonecrop 20 weight portion ~ 30 weight portion, potentilla chinensis 15 weight portion ~ 25 weight portion, conyza blinii 25 weight portion ~ 35 weight portion, rhizoma cibotii 20 weight portion ~ 30 weight portion, pass through muscle rattan 25 weight portion ~ 35 weight portion, Samson St Johswort 30 weight portion ~ 40 weight portion, parasitic loranthus 30 weight portion ~ 40 weight portion, franzenbach rhubarb root and rhizome 25 weight portion ~ 35 weight portion, Common St.Paulswort Herb 10 weight portion ~ 20 weight portion, milfoil 20 weight portion ~ 30 weight portion, Aster ageratoides 15 weight portion ~ 25 weight portion and centella 15 weight portion ~ 25 weight portion.
3. feed addictive as claimed in claim 1 or 2, is characterized in that: the weight portion of each bulk drug Wei Gorgon fruit 38 weight portion ~ 42 weight portion, rhodiola root 28 weight portion ~ 32 weight portion, wilsonii 38 weight portion ~ 42 weight portion, reticulate millettia 23 weight portion ~ 27 weight portion, Companumoea root 33 weight portion ~ 37 weight portion, sealwort 38 weight portion ~ 42 weight portion, Oroxylum indicum 18 weight portion ~ 22 weight portion, Folium Sauropi 18 weight portion ~ 22 weight portion, radix glehniae 28 weight portion ~ 32 weight portion, giant knotweed 33 weight portion ~ 37 weight portion, stringy stonecrop 23 weight portion ~ 27 weight portion, potentilla chinensis 18 weight portion ~ 22 weight portion, conyza blinii 28 weight portion ~ 32 weight portion, rhizoma cibotii 23 weight portion ~ 27 weight portion, pass through muscle rattan 28 weight portion ~ 32 weight portion, Samson St Johswort 33 weight portion ~ 37 weight portion, parasitic loranthus 33 weight portion ~ 37 weight portion, franzenbach rhubarb root and rhizome 28 weight portion ~ 32 weight portion, Common St.Paulswort Herb 13 weight portion ~ 17 weight portion, milfoil 23 weight portion ~ 27 weight portion, Aster ageratoides 18 weight portion ~ 22 weight portion and centella 18 weight portion ~ 22 weight portion.
4. the feed addictive as described in claims 1 to 3, it is characterized in that: the weight portion of each bulk drug Wei Gorgon fruit 40 weight portion, rhodiola root 30 weight portion, wilsonii 40 weight portion, reticulate millettia 25 weight portion, Companumoea root 35 weight portion, sealwort 40 weight portion, Oroxylum indicum 20 weight portion, Folium Sauropi 20 weight portion, radix glehniae 30 weight portion, giant knotweed 35 weight portion, stringy stonecrop 25 weight portion, potentilla chinensis 20 weight portion, conyza blinii 30 weight portion, rhizoma cibotii 25 weight portion, pass through muscle rattan 30 weight portion, Samson St Johswort 35 weight portion, parasitic loranthus 35 weight portion, franzenbach rhubarb root and rhizome 30 weight portion, Common St.Paulswort Herb 15 weight portion, milfoil 25 weight portion, Aster ageratoides 20 weight portion and centella 20 weight portion.
5. the preparation method of feed addictive described in Claims 1-4, is characterized in that, comprising:
The first step, by Gorgon fruit, wilsonii, Companumoea root, sealwort, radix glehniae, conyza blinii, rhizoma cibotii, Samson St Johswort, parasitic loranthus, franzenbach rhubarb root and rhizome, Common St.Paulswort Herb, milfoil, Aster ageratoides and centella are pulverized respectively, mix in proportion, mixture loads in percolator, every 500g adds ethanol 800g ~ 1000g that determining alcohol is 80% ~ 90%, soak 25 hours ~ 35 hours under the condition of 35 DEG C ~ 45 DEG C, regulate percolator valve, white wine liquid is slowly oozed, the speed of oozing is 2 ~ 4mL per minute, to the color oozed is transparent, collect the drip oozed, obtain percolate, concentrated, removing white wine, dry, pulverize, obtain the first powder,
Second step, is ground into powder respectively by bulk drug component under She, sends into stirrer for mixing, obtain mixture, every 100g mixture, adds the water of 500g ~ 600g, boil 3 ~ 4 hours, filter, obtain the first filtrate, filter residue adds the water of 200g ~ 300g again, again boils 1 ~ 2 hour, filters, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, concentrated removing aqueous solvent, pulverize, dry, obtain the second dry powder;
3rd step, by the first powder and the mixing of the second powder, adds maize cob meal with the ratio of mass ratio 1: 1 subsequently, stirs, be feed addictive.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109673840A (en) * | 2018-12-04 | 2019-04-26 | 李先奇 | A kind of novel non-pollution fertilizer additive |
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| CN102038083A (en) * | 2010-09-14 | 2011-05-04 | 周剑峰 | Traditional Chinese medicine feed additive for preventing and treating porcine reproductive and respiratory syndrome (PRRS) |
| CN102058021A (en) * | 2009-11-17 | 2011-05-18 | 程显东 | Piglet feed additive |
| CN103598460A (en) * | 2013-10-25 | 2014-02-26 | 青岛华仁技术孵化器有限公司 | Forage for preventing infectious bronchitis of chicken |
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| CN102058021A (en) * | 2009-11-17 | 2011-05-18 | 程显东 | Piglet feed additive |
| CN102038083A (en) * | 2010-09-14 | 2011-05-04 | 周剑峰 | Traditional Chinese medicine feed additive for preventing and treating porcine reproductive and respiratory syndrome (PRRS) |
| CN103598460A (en) * | 2013-10-25 | 2014-02-26 | 青岛华仁技术孵化器有限公司 | Forage for preventing infectious bronchitis of chicken |
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| CN109673840A (en) * | 2018-12-04 | 2019-04-26 | 李先奇 | A kind of novel non-pollution fertilizer additive |
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Application publication date: 20141224 |