CN103222565B - Traditional chinese medicine milk increasing agent - Google Patents
Traditional chinese medicine milk increasing agent Download PDFInfo
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- CN103222565B CN103222565B CN201310181981.XA CN201310181981A CN103222565B CN 103222565 B CN103222565 B CN 103222565B CN 201310181981 A CN201310181981 A CN 201310181981A CN 103222565 B CN103222565 B CN 103222565B
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a traditional Chinese medicine milk increasing agent, which comprises the following bulk pharmaceutical chemicals: acanthopanax, cowherb seed, beautiful sweetgum fruit, ginseng leaf, medulla of stachyurus, common gendarussa herb, radix glehniae, resina liquidamberis, hawthorn, ferula asafetida, lotus leaf, cacumen biotae, potentilla chinensis, herba eupatorii, radix psammosilenes, dandelion, liquorice, codonopsis pilosula, oyster, mangnolia officinalis, callicarpa macrophylla, Chinese yam, caulis clematidis armandii, szechwan Chinaberry fruit, hairy euphorbia, oroxylum indicum and China rose. The milk increasing agent provided by the invention can improve the production performance of dairy cow so as to produce more abundant milk, and also improves the quality of dairy products.
Description
Technical field
The present invention relates to field of feed additive technology, relate in particular to a kind of for improving the Traditional Chinese medicinal milk-increasing agent of cow producing milk performance.
Background technology
21 century, back to nature has become the inevitable requirement of survival and development of mankind, and green and healthy food is the fundamental presentation of this requirement.Along with the raising of living standards of the people, the demand of milk also increases day by day.The factor that affects milk production of cow is a lot, mainly contains various bacillary and viral infectious, tire produces disease and summer fever stress wait.
For the treatment of disease, for a long time, people mainly prevent and treat cow disease with antibiotic and other syntheticses as feed addictive, improve its Milk Production.Along with the extensive use of these additives, the toxic and side effect of dairy produce, residue problem and produce the drawbacks such as drug resistance and day by day highlight, serious harm human health.
And summer fever stress also have obvious negative consequence to milk cow.In heat stress situation, milk cow is perspired to be increased, accelerated breathing, and internal metabolism rate reduction, feed intake declines, and then the output of milk is significantly declined.The milk cow of high yield, is subject to the impact of heat stress larger.Annual summer high temperature brings huge loss all to global milk industry.At south China, annual because heat stress reduces more than 100,000 tons milk production of cow.At present a lot of for the feed addictive kind of anti heat stress for milk cow, mainly contain nicotinic acid, Organic Chromium, active dry yeasr, mineral matter buffer salt, p carrotene, fatty acid calcium etc.These are all chemical synthesis class materials, easily residual the and health of harm humans.
The object of cultivating milk cow is for production high-quality cow's milk, and cow's milk is produced not only will improve output, the more important thing is and ensures its quality.Along with the adjustment of China's agricultural structure and the raising of living standards of the people, dairy has obtained develop rapidly.But at present still disperse to raise the principal mode as raising dairy cattle taking peasant household in China some areas, and farmer breed ubiquity feeding and management level is low, backward in technique, the problem such as environmental sanitation condition is poor.Therefore, China's dairy ubiquity milk production is low, the shortcomings such as Incidence height.China's dairy is being faced with the dual test of industrial upgrading and dairy safety, and being improved milk cow production performance, improved dairy food quality by nutrition regulation is to realize the key that breaks through milk industry bottleneck.Chinese herbal feed additive becomes one of focus of domestic and international nutrient research with its unique biological function, drug residue free, the advantage such as have no side effect, Chinese herbal medicine belongs to natural drug, have with food homology, consubstantiality, with the feature of use, long-term use is difficult for producing harmful medicament residue in the livestock products such as meat, egg, milk, do not develop immunity to drugs, have no side effect, be applied to milk cow, there is the output of milk of increasing, improve milk-quality, improve the effects such as milk cow allomeric function.
China is the native place of Chinese herbal medicine, with in herbal control disease, oneself has accumulated the experience of many preciousnesses.The feature and the superiority that adopt Chinese herbal and crude drugs preparations to prevent and treat animality disease are that these Chinese herbal medicines not only have the effect of Anti-bacterium, and there is non-toxic reaction and side effect, not residual in animal body, harmless, do not pollute the environment, meet society people consumption demand.
Compared with Western medicine, the feature of Chinese herbal medicine is natural sex and versatility, and natural sex is to plant from wild or family, is organic matter instead of artificial synthetic material.Versatility comprise trophism, immunological enhancement, hormone-like effect, vitaminoid action, anti-stress with " adapting to former " sample effect, its remarkable two-way regulating function, anti-microbial effect and compound action.In addition, Chinese herbal medicine has advantages of that toxic and side effect is low, is difficult for producing drug resistance.
Modern study proves: in Chinese herbal medicine, contain multiple nutrients material and the bioactivators such as protein, amino acid, sugar, fat, starch, vitamin, trace element, can supplement body nutrition, improve animal appetite, promote animal digestion to absorb, strengthen organism metabolism, thereby raising dairy cattle, the effectively somatic quantity in Ruzhong, has the effect that cow breast keeps healthy and improves milk-quality.
Therefore, the invention provides a kind of Traditional Chinese medicinal milk-increasing agent, can improve the production performance of milk cow by this Traditional Chinese medicinal milk-increasing agent, produce abundanter milk, meanwhile, can improve the quality of dairy products.
Summary of the invention
The fodder compound that technical problem to be solved by this invention is to provide a kind of Traditional Chinese medicinal milk-increasing agent and comprises this increasing milk agent, by using this Traditional Chinese medicinal milk-increasing agent and fodder compound, can improve the production performance of milk cow, produce abundanter milk, meanwhile, can improve the quality of dairy products.
In order to solve the problems of the technologies described above, the invention provides a kind of Traditional Chinese medicinal milk-increasing agent, its bulk drug comprises: wilsonii, the seed of cowherb, play both sides of the street, folium panacis japonici cum caule, stachyurus pith, small-leaf bonesetting, radix glehniae, resina liquidamberis, hawthorn, asafoetide, lotus leaf, cacumen biotae, potentilla chinensis, eupatorium, tuniclike psammosilene root, dandelion, Radix Glycyrrhizae, Radix Codonopsis, oyster, the bark of official magnolia, bigleafbeautyberry root or leaf, Chinese yam, caulis clematidis armandii, Fructus meliae toosendan, hairy euphorbia, Oroxylum indicum and China rose.
Wherein, in described Traditional Chinese medicinal milk-increasing agent, the weight portion of each bulk drug is respectively: wilsonii 45 weight portion～55 weight portions, the seed of cowherb 40 weight portion～50 weight portions, 30 weight portion～40 weight portions play both sides of the street, folium panacis japonici cum caule's 70 weight portion～80 weight portions, stachyurus pith 35 weight portion～45 weight portions, small-leaf bonesetting 20 weight portion～30 weight portions, radix glehniae 25 weight portion～35 weight portions, resina liquidamberis 15 weight portion～25 weight portions, hawthorn 20 weight portion～30 weight portions, asafoetide 15 weight portion～25 weight portions, lotus leaf 15 weight portion～25 weight portions, cacumen biotae 25 weight portion～35 weight portions, potentilla chinensis 20 weight portion～30 weight portions, eupatorium 25 weight portion～35 weight portions, tuniclike psammosilene root 30 weight portion～40 weight portions, dandelion 40 weight portion～50 weight portions, Radix Glycyrrhizae 20 weight portion～30 weight portions, Radix Codonopsis 60 weight portion～70 weight portions, oyster 35 weight portion～45 weight portions, the bark of official magnolia 15 weight portion～25 weight portions, bigleafbeautyberry root or leaf 20 weight portion～30 weight portions, Chinese yam 35 weight portion～45 weight portions, caulis clematidis armandii 30 weight portion～40 weight portions, Fructus meliae toosendan 25 weight portion～35 weight portions, hairy euphorbia 30 weight portion～40 weight portions, Oroxylum indicum 20 weight portion～30 weight portions and China rose 35 weight portion～45 weight portions.
Wherein, in described Traditional Chinese medicinal milk-increasing agent, the weight portion of each bulk drug is respectively: wilsonii 50 weight portion～55 weight portions, the seed of cowherb 45 weight portion～50 weight portions, 35 weight portion～40 weight portions play both sides of the street, folium panacis japonici cum caule's 75 weight portion～80 weight portions, stachyurus pith 40 weight portion～45 weight portions, small-leaf bonesetting 25 weight portion～30 weight portions, radix glehniae 30 weight portion～35 weight portions, resina liquidamberis 20 weight portion～25 weight portions, hawthorn 25 weight portion～30 weight portions, asafoetide 20 weight portion～25 weight portions, lotus leaf 20 weight portion～25 weight portions, cacumen biotae 30 weight portion～35 weight portions, potentilla chinensis 20 weight portion～25 weight portions, eupatorium 25 weight portion～30 weight portions, tuniclike psammosilene root 30 weight portion～35 weight portions, dandelion 40 weight portion～45 weight portions, Radix Glycyrrhizae 20 weight portion～25 weight portions, Radix Codonopsis 60 weight portion～65 weight portions, oyster 35 weight portion～40 weight portions, the bark of official magnolia 15 weight portion～20 weight portions, bigleafbeautyberry root or leaf 20 weight portion～25 weight portions, Chinese yam 35 weight portion～40 weight portions, caulis clematidis armandii 30 weight portion～35 weight portions, Fructus meliae toosendan 25 weight portion～30 weight portions, hairy euphorbia 30 weight portion～35 weight portions, Oroxylum indicum 20 weight portion～25 weight portions and China rose 35 weight portion～40 weight portions.
Wherein, in described Traditional Chinese medicinal milk-increasing agent, the weight portion of each bulk drug is respectively: wilsonii 45 weight portion～50 weight portions, the seed of cowherb 40 weight portion～45 weight portions, 30 weight portion～35 weight portions play both sides of the street, folium panacis japonici cum caule's 70 weight portion～75 weight portions, stachyurus pith 35 weight portion～40 weight portions, small-leaf bonesetting 20 weight portion～25 weight portions, radix glehniae 25 weight portion～30 weight portions, resina liquidamberis 15 weight portion～20 weight portions, hawthorn 20 weight portion～25 weight portions, asafoetide 15 weight portion～20 weight portions, lotus leaf 15 weight portion～20 weight portions, cacumen biotae 25 weight portion～30 weight portions, potentilla chinensis 25 weight portion～30 weight portions, eupatorium 30 weight portion～35 weight portions, tuniclike psammosilene root 35 weight portion～40 weight portions, dandelion 45 weight portion～50 weight portions, Radix Glycyrrhizae 25 weight portion～30 weight portions, Radix Codonopsis 65 weight portion～70 weight portions, oyster 40 weight portion～45 weight portions, the bark of official magnolia 20 weight portion～25 weight portions, bigleafbeautyberry root or leaf 25 weight portion～30 weight portions, Chinese yam 40 weight portion～45 weight portions, caulis clematidis armandii 35 weight portion～40 weight portions, Fructus meliae toosendan 30 weight portion～35 weight portions, hairy euphorbia 35 weight portion～40 weight portions, Oroxylum indicum 25 weight portion～30 weight portions and China rose 40 weight portion～45 weight portions.
Wherein, in described Traditional Chinese medicinal milk-increasing agent, the weight portion of each bulk drug is respectively: wilsonii 50 weight portions, the seed of cowherb 45 weight portions, 35 weight portions play both sides of the street, folium panacis japonici cum caule's 75 weight portions, stachyurus pith 40 weight portions, small-leaf bonesetting 25 weight portions, radix glehniae 30 weight portions, resina liquidamberis 20 weight portions, hawthorn 25 weight portions, asafoetide 20 weight portions, lotus leaf 20 weight portions, cacumen biotae 30 weight portions, potentilla chinensis 25 weight portions, eupatorium 30 weight portions, tuniclike psammosilene root 35 weight portions, dandelion 45 amounts part, Radix Glycyrrhizae 25 weight portions, Radix Codonopsis 65 weight portions, oyster 40 weight portions, the bark of official magnolia 20 weight portions, bigleafbeautyberry root or leaf 25 weight portions, Chinese yam 40 weight portions, caulis clematidis armandii 35 weight portions, Fructus meliae toosendan 30 weight portions, hairy euphorbia 35 weight portions, Oroxylum indicum 25 weight portions and China rose 40 weight portions.
The present invention also provides the preparation method of above-mentioned Traditional Chinese medicinal milk-increasing agent, and described preparation method is specially:
The first step, by wilsonii, the seed of cowherb, play both sides of the street, folium panacis japonici cum caule, stachyurus pith, radix glehniae, Radix Codonopsis, oyster and Chinese yam be ground into respectively powder, mix in proportion, pack in percolator, the ethanol that to add with respect to the determining alcohol of 4～6 times of mixture qualities be 75%～85%, soaking at ambient temperature 20 hours～30 hours, open the valve of percolator, is that ethanolic solution slowly oozes, the speed of oozing is 2～4ml per minute, collect drip, till ethanol drop to be oozed is colourless, concentrated, remove ethanolic solution, dry, pulverize, obtain the first powder;
Second step, mixes remaining component in proportion, adds the water with respect to 5～8 times of mixture qualities, boil 2～3 hours, filter, obtain the first filtrate, filter residue adds the water with respect to 2～4 times, mixture again, again boils 1～2 hour, filters, obtain the second filtrate, the first filtrate and the second filtrate are mixed, concentrated, except anhydrating, dry, pulverize, obtain the second powder;
The 3rd step, mixes the first powder and the second powder, obtains Traditional Chinese medicinal milk-increasing agent.
The present invention also provides a kind of fodder compound, and it comprises: corn silage, alfalfa hay, medical stone, sodium bicarbonate, salt, cottonseed, compound premix and above-mentioned Traditional Chinese medicinal milk-increasing agent.
Wherein, with respect to the corn silage of 100 weight portions, the weight portion of alfalfa hay is 80 weight portion～100 weight portions, medical stone 3 weight portion～5 weight portions, the weight portion of sodium bicarbonate is 2 weight portion～4 weight portions, salt 1 weight portion～2 weight portion, cottonseed 25 weight portion～40 weight portions, compound premix 10 weight portion～20 weight portions, described Traditional Chinese medicinal milk-increasing agent 25 weight portion～35 weight portions.
Wherein, with respect to the corn silage of 100 weight portions, the weight portion of alfalfa hay is 90 weight portions, medical stone 4 weight portions, the weight portion of sodium bicarbonate is 3 weight portions, salt 2 weight portions, cottonseed 35 weight portions, compound premix 15 weight portions, described Traditional Chinese medicinal milk-increasing agent 30 weight portions.
The present invention also provides the preparation method of above-mentioned fodder compound, is specially:
The first step, the first step, by wilsonii, the seed of cowherb, play both sides of the street, folium panacis japonici cum caule, stachyurus pith, radix glehniae, Radix Codonopsis, oyster and Chinese yam are ground into respectively powder, mix in proportion, pack in percolator, the ethanol that to add with respect to the determining alcohol of 4～6 times of mixture qualities be 75%～85%, soak at ambient temperature 20 hours～30 hours, open the valve of percolator, that ethanolic solution slowly oozes, the speed of oozing is 2～4ml per minute, collect drip, till ethanol drop to be oozed is colourless, concentrated, remove ethanolic solution, dry, pulverize, obtain the first powder,
Second step, mixes remaining component in proportion, adds the water with respect to 5～8 times of mixture qualities, boil 2～3 hours, filter, obtain the first filtrate, filter residue adds the water with respect to 2～4 times, mixture again, again boils 1～2 hour, filters, obtain the second filtrate, the first filtrate and the second filtrate are mixed, concentrated, except anhydrating, dry, pulverize, obtain the second powder;
The 3rd step, mixes the first powder and the second powder, obtains Traditional Chinese medicinal milk-increasing agent;
The 4th step, sends into corn silage, alfalfa hay, medical stone, sodium bicarbonate, salt, cottonseed, compound premix and described Traditional Chinese medicinal milk-increasing agent in batch mixer and is uniformly mixed in proportion, obtains fodder compound.
Beneficial effect of the present invention:
Traditional Chinese medicinal milk-increasing agent provided by the invention can improve the production performance of milk cow, produces abundanter milk, meanwhile, can improve the quality of dairy products.
Detailed description of the invention
Lactation of Dairy Cow process is regulated and controled by prolactin, auxin and cortex hormone of aadrenaline mainly, these hormones are in conjunction with acceptor on cell, activated G protein, G albumen reactivation cyclic adenosine monophosphate activating enzymes and cyclic guanylic acid activating enzymes, they make respectively cyclic adenosine monophosphate (cAMP) and cyclic guanylic acid (cGMP) activation, the cAMP of activation has the effect of accelerating milk composition secretion, and cGMP has the synthetic effect of the milk composition of promotion.And the various active composition containing in Chinese herbal medicine is as astragalus polyose, flavones, the compositions such as saponin, have stimulating circulation, improve infiltration rate and the hormone-like effect of body to nutriment, can act on the beta receptor of target cell, improve cAMP level.Simultaneously trace element as copper can strengthen the synthetic of growth hormone, cortex hormone of aadrenaline, and then improve cAMP, cGMP content, thereby have completed the effect of promotion milk synthesis secretion.
Secondly, the generation of breast is the synthesis result that in mammary gland, the synthetic and mammary gland of novel substance selectively absorbs some composition from blood.Lactoprotein, butterfat and lactose are to utilize the materials such as amino acid, aliphatic acid, glucose and beta-hydroxybutyric acid synthetic, and these materials all directly or indirectly carry out autoblood.In Chinese herbal medicine, contain the nutritional labelings such as protein, sugar, fat, starch, vitamin, mineral matter, by promoting body metabolism, accelerate nutriment digesting and assimilating as albumen, carbohydrate and active component, accelerate on the one hand galactophore epithelial cell propagation, promote milk to increase, strengthen on the other hand mammary gland metabolism words moving, improve component content in milk, improve dairy food quality.
In addition, Chinese herbal medicine has the body immune system activity of activation, the regulating action such as antibacterial, antiviral; Induce cytokine profiles, promote the generation of interferon, interleukins; Activating macrophage, NK cell and T lymphocyte, bone-marrow-derived lymphocyte; Activate reticuloendothelial system and complement system.These effects can be protected milk cow, and the infringement of opposing cause of disease, builds up health, and promotes to increase breast, and cow mastitis has good preventive and therapeutic effect, and effectively reduces the somatic quantity in Ruzhong.
Chinese veterinarian's theory is thought: " without blood breast be difficult raw, without being difficult of breast of gas ", " gas strengthen blood is prosperous, the prosperous milk of blood is many ".Galactosis deficiency, can think due to modern scholar due to deficiency of blood the source of vital function deficiency, the etiology and pathogenesis of hypogalactia mostly due to deficient qi and blood, biochemical not enough, agalasisa can under, or stagnation of liver qi, newborn arteries and veins Kui Sai, breast must not under.Blood is wet nurse, can not lactogenesis without blood; Gas is that breast is handsome, newborn not all right without gas.Milk cow is often got angry and loses the deficiency of blood, is blood-enrich therefore improve the key of Lactation of Dairy Cow amount.Therefore,, by invigorating qi and benefiting blood, clearing and activating the channels and collaterals, regulating spleen and stomach, can improve significantly galgctogogue action.Help stomach by invigorating qi and benefiting blood, invigorating the spleen, can effectively mobilize mammary gland function, activate mammary glandular cell, improve Lactation of Dairy Cow amount, maintain the peak of giving milk, and then improve milking qualities.
Traditional Chinese medicinal milk-increasing agent provided by the invention is taking beneficial blood and stomach, soothing liver-qi stagnation, the lactogenesis of stimulating the menstrual flow as principle, and its bulk drug comprises: wilsonii, the seed of cowherb, play both sides of the street, folium panacis japonici cum caule, stachyurus pith, small-leaf bonesetting, radix glehniae, resina liquidamberis, hawthorn, asafoetide, lotus leaf, cacumen biotae, potentilla chinensis, eupatorium, tuniclike psammosilene root, dandelion, Radix Glycyrrhizae, Radix Codonopsis, oyster, the bark of official magnolia, bigleafbeautyberry root or leaf, Chinese yam, caulis clematidis armandii, Fructus meliae toosendan, hairy euphorbia, Oroxylum indicum and China rose.
Further, described Traditional Chinese medicinal milk-increasing agent is only made up of above-mentioned raw materials medicine.
Wherein, in described Traditional Chinese medicinal milk-increasing agent, the weight portion of each bulk drug is respectively: wilsonii 45 weight portion～55 weight portions, the seed of cowherb 40 weight portion～50 weight portions, 30 weight portion～40 weight portions play both sides of the street, folium panacis japonici cum caule's 70 weight portion～80 weight portions, stachyurus pith 35 weight portion～45 weight portions, small-leaf bonesetting 20 weight portion～30 weight portions, radix glehniae 25 weight portion～35 weight portions, resina liquidamberis 15 weight portion～25 weight portions, hawthorn 20 weight portion～30 weight portions, asafoetide 15 weight portion～25 weight portions, lotus leaf 15 weight portion～25 weight portions, cacumen biotae 25 weight portion～35 weight portions, potentilla chinensis 20 weight portion～30 weight portions, eupatorium 25 weight portion～35 weight portions, tuniclike psammosilene root 30 weight portion～40 weight portions, dandelion 40 weight portion～50 weight portions, Radix Glycyrrhizae 20 weight portion～30 weight portions, Radix Codonopsis 60 weight portion～70 weight portions, oyster 35 weight portion～45 weight portions, the bark of official magnolia 15 weight portion～25 weight portions, bigleafbeautyberry root or leaf 20 weight portion～30 weight portions, Chinese yam 35 weight portion～45 weight portions, caulis clematidis armandii 30 weight portion～40 weight portions, Fructus meliae toosendan 25 weight portion～35 weight portions, hairy euphorbia 30 weight portion～40 weight portions, Oroxylum indicum 20 weight portion～30 weight portions and China rose 35 weight portion～45 weight portions.
Wherein, in described Traditional Chinese medicinal milk-increasing agent, the weight portion of each bulk drug is further preferably respectively: wilsonii 50 weight portion～55 weight portions, the seed of cowherb 45 weight portion～50 weight portions, 35 weight portion～40 weight portions play both sides of the street, folium panacis japonici cum caule's 75 weight portion～80 weight portions, stachyurus pith 40 weight portion～45 weight portions, small-leaf bonesetting 25 weight portion～30 weight portions, radix glehniae 30 weight portion～35 weight portions, resina liquidamberis 20 weight portion～25 weight portions, hawthorn 25 weight portion～30 weight portions, asafoetide 20 weight portion～25 weight portions, lotus leaf 20 weight portion～25 weight portions, cacumen biotae 30 weight portion～35 weight portions, potentilla chinensis 20 weight portion～25 weight portions, eupatorium 25 weight portion～30 weight portions, tuniclike psammosilene root 30 weight portion～35 weight portions, dandelion 40 weight portion～45 weight portions, Radix Glycyrrhizae 20 weight portion～25 weight portions, Radix Codonopsis 60 weight portion～65 weight portions, oyster 35 weight portion～40 weight portions, the bark of official magnolia 15 weight portion～20 weight portions, bigleafbeautyberry root or leaf 20 weight portion～25 weight portions, Chinese yam 35 weight portion～40 weight portions, caulis clematidis armandii 30 weight portion～35 weight portions, Fructus meliae toosendan 25 weight portion～30 weight portions, hairy euphorbia 30 weight portion～35 weight portions, Oroxylum indicum 20 weight portion～25 weight portions and China rose 35 weight portion～40 weight portions.
Wherein, in described Traditional Chinese medicinal milk-increasing agent, the weight portion of each bulk drug is further preferably respectively: wilsonii 45 weight portion～50 weight portions, the seed of cowherb 40 weight portion～45 weight portions, 30 weight portion～35 weight portions play both sides of the street, folium panacis japonici cum caule's 70 weight portion～75 weight portions, stachyurus pith 35 weight portion～40 weight portions, small-leaf bonesetting 20 weight portion～25 weight portions, radix glehniae 25 weight portion～30 weight portions, resina liquidamberis 15 weight portion～20 weight portions, hawthorn 20 weight portion～25 weight portions, asafoetide 15 weight portion～20 weight portions, lotus leaf 15 weight portion～20 weight portions, cacumen biotae 25 weight portion～30 weight portions, potentilla chinensis 25 weight portion～30 weight portions, eupatorium 30 weight portion～35 weight portions, tuniclike psammosilene root 35 weight portion～40 weight portions, dandelion 45 weight portion～50 weight portions, Radix Glycyrrhizae 25 weight portion～30 weight portions, Radix Codonopsis 65 weight portion～70 weight portions, oyster 40 weight portion～45 weight portions, the bark of official magnolia 20 weight portion～25 weight portions, bigleafbeautyberry root or leaf 25 weight portion～30 weight portions, Chinese yam 40 weight portion～45 weight portions, caulis clematidis armandii 35 weight portion～40 weight portions, Fructus meliae toosendan 30 weight portion～35 weight portions, hairy euphorbia 35 weight portion～40 weight portions, Oroxylum indicum 25 weight portion～30 weight portions and China rose 40 weight portion～45 weight portions.
Wherein, in described Traditional Chinese medicinal milk-increasing agent, the weight portion of each bulk drug is most preferably respectively: wilsonii 50 weight portions, the seed of cowherb 45 weight portions, 35 weight portions play both sides of the street, folium panacis japonici cum caule's 75 weight portions, stachyurus pith 40 weight portions, small-leaf bonesetting 25 weight portions, radix glehniae 30 weight portions, resina liquidamberis 20 weight portions, hawthorn 25 weight portions, asafoetide 20 weight portions, lotus leaf 20 weight portions, cacumen biotae 30 weight portions, potentilla chinensis 25 weight portions, eupatorium 30 weight portions, tuniclike psammosilene root 35 weight portions, dandelion 45 weight portions, Radix Glycyrrhizae 25 weight portions, Radix Codonopsis 65 weight portions, oyster 40 weight portions, the bark of official magnolia 20 weight portions, bigleafbeautyberry root or leaf 25 weight portions, Chinese yam 40 weight portions, caulis clematidis armandii 35 weight portions, Fructus meliae toosendan 30 weight portions, hairy euphorbia 35 weight portions, Oroxylum indicum 25 weight portions and China rose 40 weight portions.
Fang Zhong, folium panacis japonici cum caule's tonifying Qi, qi promoting blood production, hemapodium milkization is raw active, wilsonii, Radix Codonopsis, Chinese yam, radix glehniae bowl spares invigorating the spleen, increases appetite, stachyurus pith inducing diuresis for removing edema, the lactogenesis of stimulating the menstrual flow, plays both sides of the street, the caulis clematidis armandii promoting the circulation of qi of regulating the flow of vital energy, logical newborn lactogenesis, the biological active matter mass-energy in Radix Codonopsis effectively suppresses the activity of PDH, weakens the degraded of PDH to cAMP and cGMP, the seed of cowherb, cacumen biotae, small-leaf bonesetting, tuniclike psammosilene root promoting blood circulation, lactogenesis detumescence, hawthorn, asafoetide promotes appetite, strengthens digestion merit, makes milk cow keep vigorous appetite, has ensured normal milk production, and hot summer weather is stranded spleen, the most easily affects milk cow appetite, causes the output of milk to decline, and adds lotus leaf, eupatorium clearing away summerheat, promotes milk cow appetite, potentilla chinensis, dandelion, hairy euphorbia is clearing heat and detoxicating, and soothing liver-qi stagnation prevents the generation of cow disease, and oyster also has promoting QI to circulate and dispersing the agglomeration of the pathogens effect, it can activate rapidly the hormones such as prolactin and enter lactiferous ducts together with other drug, and breast blood circulation is accelerated, and improves breast vigor, bark of official magnolia promoting the circulation of qi is led stagnant, strengthening the spleen and stomach, Fructus meliae toosendan, Oroxylum indicum is soothing the liver to expel the heat-evil, promoting qi circulation and relieving pain, China rose promoting blood circulation for regulating menstruation, soothing liver-qi stagnation, Radix Glycyrrhizae regulating spleen and stomach.
Wilsonii: latin name Acanthopanacis Senticosi Radix et Rhizoma seu Caulis, taste is pungent, bitter, micro-sweet, warm in nature, enter spleen, kidney, the heart channel of Hang-Shaoyin, have and replenish qi to invigorate the spleen, tonify the kidney to relieve mental strain, the effect of dispelling rheumatism, soft for wind-cold-dampness arthralgia, lumbocrural pain, muscles and bones impotence, be slow in action, the card such as body void is thin and weak, traumatic injury, fracture, oedema, beriberi, uncontrolled urination are itched.
The seed of cowherb: bitter, property is flat, enters liver, and stomach warp, has activating blood to promote menstruation, the lactogenesis carbuncle that disappears, the effect of inducing diuresis for treating strangurtia, cures mainly blood stasis through closing, dysmenorrhoea, difficult labour; Lack of lactation after delivery, acute mastitis swells and ache; Heat is drenched, and blood drenches, the cards such as urolithiasis.
Play both sides of the street: latin name Liquidambaris Fructus, bitter, property is flat, returns liver, and kidney channel, has dispelling, collateral-activating, effect that Li Shui stimulates the menstrual flow, for joint pain, numbness contracture, oedema turgor, breast is few through the card such as closing.
Folium panacis japonici cum caule: bitter, sweet, cold in nature, attach to the lung and stomach meridians, there is tonifying Qi, beneficial lung, drives away summer heat, and the effect of promoting the production of body fluid, cures mainly qi-asthenia cough, hot summer weather agitation, Tianjin wound is thirsty, and the head is unclear, the tired weary card that waits of four limbs.
Stachyurus pith: taste is sweet, light, cold in nature, attaches to the lung and stomach meridians, has effect of heat-clearing, diuresis, lactogenesis, cures mainly difficult urination, the cards such as stranguria and agalactia.
Small-leaf bonesetting: latin name Gendarussae Herba, taste is pungent, hardship, property is flat, returns liver, kidney, lung channel, has wines used as antirheumatic; Loose hemostasis; Effect of continuous muscles and bones, cures mainly arthralgia due to wind-dampness; Irregular menstruation; Postpartum abdominal pain; Treating swelling and pain by traumatic injury; The cards such as fracture.
Radix glehniae: cold nature, sweet, the micro-hardship of taste, has nourishiing yin to clear away the lung-heat, and effect of reinforcing stomach reg fluid cures mainly the cough cards such as phlegm blood, pyreticosis Tianjin wound is thirsty of lung-heat type cough, labor.
Resina liquidamberis: latin name Resina Liquidambaris, pungent, the micro-hardship of taste, property is flat, returns lung, the spleen channel, has promoting blood circulation and stopping pain, detoxify and promote granulation, effect of cooling blood and hemostasis, cures mainly traumatic injury, and ulcer pain is spitted blood, the cards such as traumatism and bleeding.
Hawthorn: taste acid, sweet, slightly warm in nature, returns spleen, stomach, Liver Channel, has food digesting stomach fortifying, effect of the loose stasis of blood of promoting the circulation of qi, is mainly used to treat accumulation of food in the stomach and intes tine due to indigestion, has loose bowels, and dysentery, hawthorn is the staple for the treatment of indigestion, and hawthorn can increase the secretion of peptic digest enzyme, promotes the cards such as digestion.
Asafoetide: bitter, pungent, warm in nature, return kidney, stomach warp, have disappear long-pending, loose ruffian, effect of desinsection, stagnant for meat, hemostasis abdominal mass, mass in abdomen, the cards such as abdominal pain due to enterositosis.
Lotus leaf: bitter, pungent, micro-puckery, cool in nature, the thoughts of returning home, liver, the spleen channel, have summer heat relieving and dampness eliminating, invigorating the spleen rises sun, and effect of loose stasis of blood hemostasis, cures mainly hot summer weather polydipsia, has a headache dizzy, oedema, the few abdominal distension of food, rushes down dysentery, leukorrhea, prolapse of the anus, spits blood, bleeding from five sense organs or subcutaneous tissue, spitting of blood, has blood in stool, uterine bleeding, post partum longtime lochia, the cards such as traumatic blood stasis.
Cacumen biotae: bitter, puckery, cold in nature, enter the heart, liver, large intestine channel, there is cooling blood and hemostasis, wines used as antirheumatic, effect of loose pyogenic infections, cures mainly haematemesis, bleeding from five sense organs or subcutaneous tissue, hematuria, bloody flux, intestines wind, uterine bleeding, arthralgia due to wind-dampness, bacillary dysentery, hypertension, cough, erysipelas, mumps, the cards such as scald.
Potentilla chinensis: bitter, cold in nature, return liver, large intestine channel, has heat-clearing and damp-drying drug, the effect of removing heat from the blood and relieve diarrhea, for damp-heat dysentery, have loose bowels, the card such as dysentery, stomachache, acute bacterial are understood, blood-head is hemorrhage, spit blood, have blood in stool, hematuria, uterine bleeding.
Eupatorium: taste is pungent, property is flat, returns spleen, stomach, lung channel, has expelling summer-heat and damp, ward off dirty and in effect, cure mainly summer-heat and damp, fever and chills headache, accumulates in moistening, gastral cavity ruffian is not hungry, n and V is sweet greasy in mouthful, disappears and truly waits card.
Tuniclike psammosilene root: latin name Psammosilenes Radix, bitter, pungent, warm in nature, return Liver Channel, have and dispel rheumatism, blood stasis removing analgesic, effect of removing toxicity for detumescence, cures mainly arthralgia due to wind-dampness, stomachache with cool feeling, traumatic injury, traumatism and bleeding, the cards such as worm snake bite.
Dandelion: taste is sweet, bitter, cold in nature, enter liver, stomach warp, have clearing heat and detoxicating, the carbuncle that disappears dissipating bind, clear liver and improve vision, the effect of inducing diuresis for treating strangurtia, be mainly used in the treatment of sore swollen toxin, especially remarkable to acute mastitis effect, also can be used for the treatment of the symptoms such as the red eye, swell pain of liver-fire flaming, in addition, also there is the effect of promoting urination and removing dampness, be used for controlling jaundice with damp-heat pathogen, difficult urination, the treatment of the illnesss such as urinary system infection contamination, the yellow gold-coloured staphylococci of common reply, Escherichia coli, Pseudomonas aeruginosa, shigella flexneri, paratyphoid A, white beads Niu Jun, ox type Brucella has certain bacteriostasis, to Trichophyton concentricum, permitted haze achorion, the little Bacillus of rust, gypsum sample budlet spore tinea bacterium etc. and all had bacteriostasis.
Radix Glycyrrhizae: taste is sweet, property is flat, enters 12 warps, has clearing heat and detoxicatingly, is in harmonious proportion the property of medicine, the effect of expelling phlegm and arresting coughing, and can invigorating the spleen and in, relieving spasm to stop pain, is mainly used in weakness of the spleen and the stomach abdominal distension and anorexia, weak; Can alleviate contraction pain in abdomen, relax the strong and toxicity of some drugs, alleviate the toxic and side effect of medicine to body or to GI stimulation.
Radix Codonopsis: taste is sweet, property is flat, enters lung, the spleen channel, has tonifying Qi benefit spleen, the symptoms such as the effect of nourishing blood to promote the production of body fluid, is mainly used in spleen-lung Qi deficiency or qi-blood deficiency lassitude hypodynamia, breathes hard, cough spontaneous perspiration, Radix Codonopsis is longer than tonifying spleen nourishing the stomach, adjust regulating the function of middle-JIAO, have the effect of nourishing blood concurrently, its property is flat, invigorating the spleen fortune and not dry; Flavour is cloudy and not wet, can improve the immune state of body, improves resistance against diseases, promotes to digest and assimilate, and improves metabolism.
Oyster: taste is salty, cold nature, enters liver, courage, kidney channel, has calming the liver, tranquillizing the mind by relieving convulsion, softening and resolving hard mass, restrains astringent or styptic treatment for spontaneous sweating effect, cure mainly dizzy tinnitus, brothers' chatter, palpitation and insomnia, have the fidgets, frightened epilepsy is demented, scrofula goiter and tumor, breast caking, spontaneous sweating, seminal emission frequent micturition, under uterine bleeding band, acid regurgitation stomachache, the cards such as eczema sore.
The bark of official magnolia: bitter, pungent, warm in nature, return the spleen channel; Stomach warp; Large intestine channel, has promoting the circulation of qi and disappears long-pending; Eliminating dampness is except full; Effect of relieving asthma, cures mainly stagnation of QI due to dyspepsia; Abdominal distention constipation; Damp retention in middle-jiao, gastral cavity ruffian is vomited and diarrhoea; Phlegm is stopped up the circulation of vital energy in the wrong direction; The fullness sensation in chest card such as breath with cough.
Bigleafbeautyberry root or leaf: taste is pungent, bitter, property is flat, returns liver, lung, stomach warp, has effect of loose stasis of blood hemostasis, swelling and pain relieving, cures mainly hemoptysis, spits blood, has blood in stool, traumatism and bleeding, falls cards such as flutterring pain.
Chinese yam: taste is sweet, property is put down, enter lung, spleen, kidney channel, have strengthening the spleen and tonifying the lung, beneficial stomach kidney tonifying, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, effect of helping the five internal organs, strengthening the bones and muscles, long will to calm the nerves, promote longevity, cure mainly that weakness of the spleen and the stomach, lassitude, poor appetite, chronic diarrhea and dysentery, Lung Qi deficiency are dry, asthma due to excessive phlegm cough, kidney qi loss, soreness and weakness of waist and knees, lower limb impotence are weak, the red card such as swollen, fat of gonorrhoea under the frequent micturition of quenching one's thirst, seminal emission premature ejaculation, band, skin.
Caulis clematidis armandii: latin name Caulis Clematis Armanoii, lightly seasoned, bitter, cold in nature, the thoughts of returning home, lung, small intestine, urinary bladder channel, have reducing fever and causing diuresis, effect of the lactogenesis of stimulating the menstrual flow cures mainly oedema, gonorrhoea, urinary obstruction, joint pain, through close breast less, fall fire etc. card.
Fructus meliae toosendan: bitter, cold in nature, return liver, small intestine, urinary bladder channel, have soothing the liverly expel the heat-evil, effect of promoting qi circulation and relieving pain, cure mainly liver depression forming fire, the chest side of body, play the cards such as abdominal distention and pain, hernia pain, abdominal pain due to enterositosis.
Hairy euphorbia: latin name Euphorbiae Hirate Herba, mildly bitter flavor, micro-acid, cool in nature, have clearing heat and detoxicating, effect that dampness removing is antipruritic, for bacillary dysentery, amoebic dysentery, enteritis, enteron aisle trichomonad, indigestion, bronchitis, pyelonephritis; The cards such as eczema, dermatitis, pruitus are controlled in external application.
Oroxylum indicum: latin name Semen Oroxyli, mildly bitter flavor; Sweet; Cold nature, returns lung; Liver; Stomach warp, has relieve sore throat moistening lung; Soothing liver and harmonizing stomach; Effect of expelling pus and promoting granulation, cures mainly pharyngalgia larynx numbness; Hoarseness; Cough; Stomachache due to emotional depression and the hyperactive liver-qi attacking the stomach; Sore is burst and is not held back for a long time; The cards such as acute eczema.
China rose: latin name Rosae Chinensis Flos, taste is sweet, warm in nature, returns Liver Channel, has promoting blood circulation for regulating menstruation, and effect of soothing liver-qi stagnation, cures mainly qi depression to blood stasis, irregular menstruation, dysmenorrhoea, amenorrhoea, the cards such as distending pain in the chest and hypochondrium.
The present invention also provides the preparation method of above-mentioned Traditional Chinese medicinal milk-increasing agent, and described preparation method is specially:
The first step, by wilsonii, the seed of cowherb, play both sides of the street, folium panacis japonici cum caule, stachyurus pith, radix glehniae, Radix Codonopsis, oyster and Chinese yam be ground into respectively powder, mix in proportion, pack in percolator, the ethanol that to add with respect to the determining alcohol of 4～6 times of mixture qualities be 75%～85%, soaking at ambient temperature 20 hours～30 hours, open the valve of percolator, is that ethanolic solution slowly oozes, the speed of oozing is 2～4ml per minute, collect drip, till ethanol drop to be oozed is colourless, concentrated, remove ethanolic solution, dry, pulverize, obtain the first powder;
Second step, mixes remaining component in proportion, adds the water with respect to 5～8 times of mixture qualities, boil 2～3 hours, filter, obtain the first filtrate, filter residue adds the water with respect to 2～4 times, mixture again, again boils 1～2 hour, filters, obtain the second filtrate, the first filtrate and the second filtrate are mixed, concentrated, except anhydrating, dry, pulverize, obtain the second powder;
The 3rd step, mixes the first powder and the second powder, obtains Traditional Chinese medicinal milk-increasing agent.
Traditional Chinese medicinal milk-increasing agent provided by the invention can be dissolved in water, is mixed with the solution that crude drug concentration is 2g/ml～4g/ml.
Traditional Chinese medicinal milk-increasing agent provided by the invention can also be sneaked in the daily edible feed of milk cow, altogether milk cow feeding.
The present invention also provides a kind of fodder compound, and it comprises: corn silage, alfalfa hay, medical stone, sodium bicarbonate, salt, cottonseed, compound premix and above-mentioned Traditional Chinese medicinal milk-increasing agent.
Further, described fodder compound is preferably only made up of said components.
Wherein, with respect to the corn silage of 100 weight portions, the weight portion of alfalfa hay is 80 weight portion～100 weight portions, medical stone 3 weight portion～5 weight portions, the weight portion of sodium bicarbonate is 2 weight portion～4 weight portions, salt 1 weight portion～2 weight portion, cottonseed 25 weight portion～40 weight portions, compound premix 10 weight portion～20 weight portions, described Traditional Chinese medicinal milk-increasing agent 25 weight portion～35 weight portions.
Further preferably, with respect to the corn silage of 100 weight portions, the weight portion of alfalfa hay is 90 weight portions, medical stone 4 weight portions, the weight portion of sodium bicarbonate is 3 weight portions, salt 2 weight portions, cottonseed 35 weight portions, compound premix 15 weight portions, described Traditional Chinese medicinal milk-increasing agent 30 weight portions.
Described compound premix newly wishes six and the composite premix for cows CB15 that provides of group by Shandong, it contains composition iodine 100mg/kg, zinc 8g/kg, manganese 2.5g/kg, copper 2g/kg, selenium 60mg/kg, cobalt 20mg/kg, vitamin A 600 000IU, vitamin D 100000IU, vitamin E 4000IU, described compound premix can be also any conventional compound premix.
The present invention also provides the preparation method of above-mentioned fodder compound, is specially:
The first step, prepares described Traditional Chinese medicinal milk-increasing agent according to the method described above;
Second step, puts into mix and blend in batch mixer by rice ensiling, alfalfa hay, medical stone, sodium bicarbonate, salt, cottonseed, compound premix and above-mentioned Traditional Chinese medicinal milk-increasing agent in described ratio, obtains fodder compound.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1 Traditional Chinese medicinal milk-increasing agent 1
By wilsonii 50g, seed of cowherb 45g, 35g plays both sides of the street, folium panacis japonici cum caule 75g, stachyurus pith 40g, radix glehniae 30g, Radix Codonopsis 65g, oyster 40g and Chinese yam 40g are ground into respectively powder, mix, and pack in percolator, the ethanol that the determining alcohol that adds 2kg is 85%, soaks 30 hours at ambient temperature, opens the valve of percolator, be that ethanolic solution slowly oozes, the speed of oozing is 3ml per minute, collects drip, till ethanol drop to be oozed is colourless, concentrated, remove ethanolic solution, dry, pulverize, obtain the first powder, by small-leaf bonesetting 25g, resina liquidamberis 20g, hawthorn 25g, asafoetide 20g, lotus leaf 20g, cacumen biotae 30g, potentilla chinensis 25g, eupatorium 30g, tuniclike psammosilene root 35g, dandelion 45g, Radix Glycyrrhizae 25g, bark of official magnolia 20g, bigleafbeautyberry root or leaf 25g, caulis clematidis armandii 35g, Fructus meliae toosendan 30g, hairy euphorbia 35g, Oroxylum indicum 25g and China rose 40g mix, and add the water of 3.2kg, boil 3 hours, filter, obtain the first filtrate, filter residue adds the water of 1.5kg again, again boil 2 hours, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, concentrated, except anhydrating, dry, pulverize, obtain the second powder, the first powder and the second powder are mixed, obtain Traditional Chinese medicinal milk-increasing agent 1.
Embodiment 2 Traditional Chinese medicinal milk-increasing agent 2
By wilsonii 45g, seed of cowherb 40g, 30g plays both sides of the street, folium panacis japonici cum caule 70g, stachyurus pith 35g, radix glehniae 25g, Radix Codonopsis 70g, oyster 45g and Chinese yam 45g are ground into respectively powder, mix, and pack in percolator, the ethanol that the determining alcohol that adds 2kg is 85%, soaks 30 hours at ambient temperature, opens the valve of percolator, be that ethanolic solution slowly oozes, the speed of oozing is 3ml per minute, collects drip, till ethanol drop to be oozed is colourless, concentrated, remove ethanolic solution, dry, pulverize, obtain the first powder, by small-leaf bonesetting 20g, resina liquidamberis 15g, hawthorn 20g, asafoetide 15g, lotus leaf 15g, cacumen biotae 25g, potentilla chinensis 30g, eupatorium 35g, tuniclike psammosilene root 40g, dandelion 50g, Radix Glycyrrhizae 30g, bark of official magnolia 25g, bigleafbeautyberry root or leaf 30g, caulis clematidis armandii 40g, Fructus meliae toosendan 35g, hairy euphorbia 40g, Oroxylum indicum 30g and China rose 45g mix, and add the water of 3.5kg, boil 3 hours, filter, obtain the first filtrate, filter residue adds the water of 2kg again, again boil 2 hours, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, concentrated, except anhydrating, dry, pulverize, obtain the second powder, the first powder and the second powder are mixed, obtain Traditional Chinese medicinal milk-increasing agent 2.
Embodiment 3 Traditional Chinese medicinal milk-increasing agent 3
By wilsonii 55g, seed of cowherb 50g, 40g plays both sides of the street, folium panacis japonici cum caule 80g, stachyurus pith 45g, radix glehniae 35g, Radix Codonopsis 60g, oyster 35g and Chinese yam 35g are ground into respectively powder, mix, and pack in percolator, the ethanol that the determining alcohol that adds 2kg is 85%, soaks 30 hours at ambient temperature, opens the valve of percolator, be that ethanolic solution slowly oozes, the speed of oozing is 3ml per minute, collects drip, till ethanol drop to be oozed is colourless, concentrated, remove ethanolic solution, dry, pulverize, obtain the first powder, by small-leaf bonesetting 30g, resina liquidamberis 25g, hawthorn 30g, asafoetide 25g, lotus leaf 25g, cacumen biotae 35g, potentilla chinensis 20g, eupatorium 25g, tuniclike psammosilene root 30g, dandelion 40g, Radix Glycyrrhizae 20g, bark of official magnolia 15g, bigleafbeautyberry root or leaf 20g, caulis clematidis armandii 30g, Fructus meliae toosendan 25g, hairy euphorbia 30g, Oroxylum indicum 30g and China rose 45g mix, and add the water of 3kg, boil 3 hours, filter, obtain the first filtrate, filter residue adds the water of 1.5kg again, again boil 2 hours, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, concentrated, except anhydrating, dry, pulverize, obtain the second powder, the first powder and the second powder are mixed, obtain Traditional Chinese medicinal milk-increasing agent 3.
Embodiment 4 feeds
By the corn silage of 1kg, the alfalfa hay of 0.9kg, 40g medical stone, 30g sodium bicarbonate, 20g salt, 350g cottonseed, 150g Shandong newly wishes six and the composite premix for cows CB15 that provides of group, 300g Traditional Chinese medicinal milk-increasing agent 1 is put into mixer and is stirred, and mixes, and obtains feed.
The toxicological experiment of embodiment 5 Traditional Chinese medicinal milk-increasing agent 1
Acute toxicity testing
Select 20 of Kunming mouses, female half and half, body weight (20+2) g, provide Traditional Chinese medicinal milk-increasing agent 1 prepared by embodiment 1 to be dissolved in water by Qingdao City's Experimental Animal Center, be mixed with the solution of crude drug concentration 3g/ml, gavage mouse, through preliminary experiment, fail to detect the LD of oral administration
50, therefore survey its maximal tolerance dose, with the administration volume of 1.4ml/10g body weight, gavage 2 times/d, interval 6h, give observation post administration 7d, record animal dead and toxicity symptom, when experiment finishes, by all animals processing, dissect, visually observe each main organs lesion tissue situation, gavage for 2 times after 140g crude drug/kg, animal activity, feed water inlet does not show any abnormalities, observe 7d animal dead, gross necropsy has no the obviously abnormal of main organs tissue, therefore, the maximum dosage-feeding of Chinese herbal granules is >140g crude drug/kg, this dosage is equivalent to 70 times of maximum oral dose 2g crude drug/kg clinical adult (by 60kg) every day.
Long term toxicity test
Select 40 male SD rats, weight (180 ± 20) g, provided by Qingdao City's Experimental Animal Center, be divided at random 2 groups, blank group and Traditional Chinese medicinal milk-increasing agent group, every group 20, blank group gives distilled water, the Traditional Chinese medicinal milk-increasing agent 1 that Chinese drug-treated group is prepared embodiment 1 is dissolved in water, be mixed with the solution of crude drug concentration 3g/ml, gavage rat, the amount of gavaging is 50g crude drug/kg, on every Mondays to gastric infusion 1 time in morning Saturday, 180d continuously, administration volume is 2ml/100g body weight, observe rat general state every day before administration and during administration, sign, food ration, drinking-water and ight soil situation.When administration 90d, after last administration 24h, each group extracts 6, male and female half and half; When 180d, after last administration 24h, each group extracts 6, male and female half and half; After drug withdrawal, 30d respectively organizes and extracts 6, male and female half and half, anaesthetize with urethane, get blood from abdominal aortic, each group is all killed and gets animal, checks hematology and blood parameters, gets after blood, amass wealth by heavy taxation at once core, the internal organs such as liver,kidney,spleen, lung, adrenal gland, thyroid gland, thymus gland, testis, ovary, uterus, brain, prostate weigh, according to weight calculator official weight coefficient and make pathological examination.
On inspection, during successive administration, activity, body weight, food ration, stool and the hair luster degree no abnormality seen of animal, it is dead that animal has no, naked eyes have no obvious pathology, the inspection of each group rat peripheral hemogram is all in normal range (NR), and the raw tea index of blood is all in normal range (NR), and Chinese drug-treated group Rats Organs and Tissues coefficient does not have significant difference compared with blank group.
Can find out from embodiment 5, the clinical use of Chinese medicine composition of the present invention is safe.
Embodiment 6 raising data
1. breeding milk cow
Select the body weight of Nai Mou cattle farm, Qingdao City in 550kg left and right, 3～6 parity, in lactation mid-term, milk production 120 of close china holstein cowses.Be divided at random 3 groups, 40 every group, be respectively treatment group 1, treatment group 2 and control group.
2. feeding method
The corn silage for the treatment of group 1 and control group feeding 1kg, the alfalfa hay of 0.9kg, 40g medical stone, 30g sodium bicarbonate, 20g salt, 350g cottonseed mixes the feed forming, every day free feeding, meanwhile, treatment group gavages the solution that Traditional Chinese medicinal milk-increasing agent 1 that 600ml prepared by embodiment 1 configures 1 every day, and collocation method is that Traditional Chinese medicinal milk-increasing agent 1 prepared by embodiment 1 is dissolved in water, be mixed with the solution of crude drug concentration 3g/ml, point gavage for 3 times, feed prepared by treatment group feeding embodiment 2 every day 4, every day free feeding.
3. testing index and method
Accurately weighed, record the output of milk of every group every ox 1d in the 0th, 25,45 days experimental periods.
4. milk composition detects
In the 0th, 25,45 days experimental periods every ox take 30ml breast sample, measure butterfat and the content of milk protein of milk with Series300 Combifoss milk analytical instrument (Denmark).
Statistical analysis
Each group data are all used mean soil standard deviation
represent, respectively organize mean and do test of normality and duplicate measurements homogeneity test of variance, younger inspection between organizing with one-way analysis of variance), P<0.05 is for differing significantly, and P<0.01 is for differing highly significant.Statistical computation all adopts SPSS12.0 software to complete.
Result
On the impact of milk production of cow, the results are shown in Table 1.
The affect kgd of table 1 Traditional Chinese medicinal milk-increasing agent on milk production of cow
-1
As can be seen from Table 1, adopt Traditional Chinese medicinal milk-increasing agent of the present invention can significantly improve the output of milk of milk cow, compared with control group, significant difference, has comparativity.
On the impact of Milk Fat Percentage in Dairy Cows, the results are shown in Table 2.
The affect % of table 2 Traditional Chinese medicinal milk-increasing agent on Milk Fat Percentage in Dairy Cows
As can be seen from Table 2, adopt Traditional Chinese medicinal milk-increasing agent of the present invention can significantly improve the butterfat percnetage of dairy cow milk, compared with control group, significant difference, has comparativity.
On the impact of milk cow content of milk protein, the results are shown in Table 3.
The affect % of table 3 Traditional Chinese medicinal milk-increasing agent on milk cow content of milk protein
As can be seen from Table 3, adopt Traditional Chinese medicinal milk-increasing agent of the present invention can significantly improve the content of milk protein of dairy cow milk, compared with control group, significant difference, has comparativity.
Can find out from table 2 and table 3, adopt Traditional Chinese medicinal milk-increasing agent of the present invention can significantly improve the Milk Quality of milk cow.
All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing amendment, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only preferred embodiment of the present invention, is not the restriction of the present invention being made to other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. a Traditional Chinese medicinal milk-increasing agent, is characterized in that: the bulk drug of described Traditional Chinese medicinal milk-increasing agent only by wilsonii, the seed of cowherb, play both sides of the street, folium panacis japonici cum caule, stachyurus pith, small-leaf bonesetting, radix glehniae, resina liquidamberis, hawthorn, asafoetide, lotus leaf, cacumen biotae, potentilla chinensis, eupatorium, tuniclike psammosilene root, dandelion, Radix Glycyrrhizae, Radix Codonopsis, oyster, the bark of official magnolia, bigleafbeautyberry root or leaf, Chinese yam, caulis clematidis armandii, Fructus meliae toosendan, hairy euphorbia, Oroxylum indicum and China rose form;
In described Traditional Chinese medicinal milk-increasing agent, the weight portion of each bulk drug is respectively wilsonii 45 weight portion～55 weight portions, the seed of cowherb 40 weight portion～50 weight portions, 30 weight portion～40 weight portions play both sides of the street, folium panacis japonici cum caule's 70 weight portion～80 weight portions, stachyurus pith 35 weight portion～45 weight portions, small-leaf bonesetting 20 weight portion～30 weight portions, radix glehniae 25 weight portion～35 weight portions, resina liquidamberis 15 weight portion～25 weight portions, hawthorn 20 weight portion～30 weight portions, asafoetide 15 weight portion～25 weight portions, lotus leaf 15 weight portion～25 weight portions, cacumen biotae 25 weight portion～35 weight portions, potentilla chinensis 20 weight portion～30 weight portions, eupatorium 25 weight portion～35 weight portions, tuniclike psammosilene root 30 weight portion～40 weight portions, dandelion 40 weight portion～50 weight portions, Radix Glycyrrhizae 20 weight portion～30 weight portions, Radix Codonopsis 60 weight portion～70 weight portions, oyster 35 weight portion～45 weight portions, the bark of official magnolia 15 weight portion～25 weight portions, bigleafbeautyberry root or leaf 20 weight portion～30 weight portions, Chinese yam 35 weight portion～45 weight portions, caulis clematidis armandii 30 weight portion～40 weight portions, Fructus meliae toosendan 25 weight portion～35 weight portions, hairy euphorbia 30 weight portion～40 weight portions, Oroxylum indicum 20 weight portion～30 weight portions and China rose 35 weight portion～45 weight portions,
The preparation method of described Traditional Chinese medicinal milk-increasing agent is specially,
The first step, by wilsonii, the seed of cowherb, play both sides of the street, folium panacis japonici cum caule, stachyurus pith, radix glehniae, Radix Codonopsis, oyster and Chinese yam be ground into respectively powder, mix in proportion, pack in percolator, the ethanol that to add with respect to the determining alcohol of 4～6 times of mixture qualities be 75%～85%, soak at ambient temperature 20 hours～30 hours, open the valve of percolator, ethanolic solution is slowly oozed, the speed of oozing is 2～4ml per minute, collect drip, till ethanol drop to be oozed is colourless, concentrated, remove ethanolic solution, dry, pulverize, obtain the first powder;
Second step, mixes remaining component in proportion, adds the water with respect to 5～8 times of mixture qualities, boil 2～3 hours, filter, obtain the first filtrate, filter residue adds the water with respect to 2～4 times, mixture again, again boils 1～2 hour, filters, obtain the second filtrate, the first filtrate and the second filtrate are mixed, concentrated, except anhydrating, dry, pulverize, obtain the second powder;
The 3rd step, mixes the first powder and the second powder, obtains Traditional Chinese medicinal milk-increasing agent.
2. Traditional Chinese medicinal milk-increasing agent as claimed in claim 1, is characterized in that: in described Traditional Chinese medicinal milk-increasing agent, the weight portion of each bulk drug is respectively wilsonii 50 weight portion～55 weight portions, the seed of cowherb 45 weight portion～50 weight portions, 35 weight portion～40 weight portions play both sides of the street, folium panacis japonici cum caule's 75 weight portion～80 weight portions, stachyurus pith 40 weight portion～45 weight portions, small-leaf bonesetting 25 weight portion～30 weight portions, radix glehniae 30 weight portion～35 weight portions, resina liquidamberis 20 weight portion～25 weight portions, hawthorn 25 weight portion～30 weight portions, asafoetide 20 weight portion～25 weight portions, lotus leaf 20 weight portion～25 weight portions, cacumen biotae 30 weight portion～35 weight portions, potentilla chinensis 20 weight portion～25 weight portions, eupatorium 25 weight portion～30 weight portions, tuniclike psammosilene root 30 weight portion～35 weight portions, dandelion 40 weight portion～45 weight portions, Radix Glycyrrhizae 20 weight portion～25 weight portions, Radix Codonopsis 60 weight portion～65 weight portions, oyster 35 weight portion～40 weight portions, the bark of official magnolia 15 weight portion～20 weight portions, bigleafbeautyberry root or leaf 20 weight portion～25 weight portions, Chinese yam 35 weight portion～40 weight portions, caulis clematidis armandii 30 weight portion～35 weight portions, Fructus meliae toosendan 25 weight portion～30 weight portions, hairy euphorbia 30 weight portion～35 weight portions, Oroxylum indicum 20 weight portion～25 weight portions and China rose 35 weight portion～40 weight portions.
3. Traditional Chinese medicinal milk-increasing agent as claimed in claim 1, is characterized in that: in described Traditional Chinese medicinal milk-increasing agent, the weight portion of each bulk drug is respectively wilsonii 45 weight portion～50 weight portions, the seed of cowherb 40 weight portion～45 weight portions, 30 weight portion～35 weight portions play both sides of the street, folium panacis japonici cum caule's 70 weight portion～75 weight portions, stachyurus pith 35 weight portion～40 weight portions, small-leaf bonesetting 20 weight portion～25 weight portions, radix glehniae 25 weight portion～30 weight portions, resina liquidamberis 15 weight portion～20 weight portions, hawthorn 20 weight portion～25 weight portions, asafoetide 15 weight portion～20 weight portions, lotus leaf 15 weight portion～20 weight portions, cacumen biotae 25 weight portion～30 weight portions, potentilla chinensis 25 weight portion～30 weight portions, eupatorium 30 weight portion～35 weight portions, tuniclike psammosilene root 35 weight portion～40 weight portions, dandelion 45 weight portion～50 weight portions, Radix Glycyrrhizae 25 weight portion～30 weight portions, Radix Codonopsis 65 weight portion～70 weight portions, oyster 40 weight portion～45 weight portions, the bark of official magnolia 20 weight portion～25 weight portions, bigleafbeautyberry root or leaf 25 weight portion～30 weight portions, Chinese yam 40 weight portion～45 weight portions, caulis clematidis armandii 35 weight portion～40 weight portions, Fructus meliae toosendan 30 weight portion～35 weight portions, hairy euphorbia 35 weight portion～40 weight portions, Oroxylum indicum 25 weight portion～30 weight portions and China rose 40 weight portion～45 weight portions.
4. Traditional Chinese medicinal milk-increasing agent as claimed in claim 1, it is characterized in that: in described Traditional Chinese medicinal milk-increasing agent, the weight portion of each bulk drug is respectively wilsonii 50 weight portions, the seed of cowherb 45 weight portions, 35 weight portions play both sides of the street, folium panacis japonici cum caule's 75 weight portions, stachyurus pith 40 weight portions, small-leaf bonesetting 25 weight portions, radix glehniae 30 weight portions, resina liquidamberis 20 weight portions, hawthorn 25 weight portions, asafoetide 20 weight portions, lotus leaf 20 weight portions, cacumen biotae 30 weight portions, potentilla chinensis 25 weight portions, eupatorium 30 weight portions, tuniclike psammosilene root 35 weight portions, dandelion 45 weight portions, Radix Glycyrrhizae 25 weight portions, Radix Codonopsis 65 weight portions, oyster 40 weight portions, the bark of official magnolia 20 weight portions, bigleafbeautyberry root or leaf 25 weight portions, Chinese yam 40 weight portions, caulis clematidis armandii 35 weight portions, Fructus meliae toosendan 30 weight portions, hairy euphorbia 35 weight portions, Oroxylum indicum 25 weight portions and China rose 40 weight portions.
5. the preparation method of Traditional Chinese medicinal milk-increasing agent described in claim 1 to 4 any one, is characterized in that: described preparation method is specially,
The first step, by wilsonii, the seed of cowherb, play both sides of the street, folium panacis japonici cum caule, stachyurus pith, radix glehniae, Radix Codonopsis, oyster and Chinese yam be ground into respectively powder, mix in proportion, pack in percolator, the ethanol that to add with respect to the determining alcohol of 4～6 times of mixture qualities be 75%～85%, soak at ambient temperature 20 hours～30 hours, open the valve of percolator, ethanolic solution is slowly oozed, the speed of oozing is 2～4ml per minute, collect drip, till ethanol drop to be oozed is colourless, concentrated, remove ethanolic solution, dry, pulverize, obtain the first powder;
Second step, mixes remaining component in proportion, adds the water with respect to 5～8 times of mixture qualities, boil 2～3 hours, filter, obtain the first filtrate, filter residue adds the water with respect to 2～4 times, mixture again, again boils 1～2 hour, filters, obtain the second filtrate, the first filtrate and the second filtrate are mixed, concentrated, except anhydrating, dry, pulverize, obtain the second powder;
The 3rd step, mixes the first powder and the second powder, obtains Traditional Chinese medicinal milk-increasing agent.
6. a fodder compound, is characterized in that, comprising: Traditional Chinese medicinal milk-increasing agent described in corn silage, alfalfa hay, medical stone, sodium bicarbonate, salt, cottonseed, compound premix and claim 1 to 4 any one.
7. fodder compound as claimed in claim 6, it is characterized in that: with respect to the corn silage of 100 weight portions, the weight portion of alfalfa hay is 80 weight portion～100 weight portions, medical stone 3 weight portion～5 weight portions, the weight portion of sodium bicarbonate is 2 weight portion～4 weight portions, salt 1 weight portion～2 weight portion, cottonseed 25 weight portion～40 weight portions, compound premix 10 weight portion～20 weight portions, described Traditional Chinese medicinal milk-increasing agent 25 weight portion～35 weight portions.
8. fodder compound as claimed in claim 6, it is characterized in that: with respect to the corn silage of 100 weight portions, the weight portion of alfalfa hay is 90 weight portions, medical stone 4 weight portions, the weight portion of sodium bicarbonate is 3 weight portions, salt 2 weight portions, cottonseed 35 weight portions, compound premix 15 weight portions, described Traditional Chinese medicinal milk-increasing agent 30 weight portions.
9. the preparation method of fodder compound described in claim 6, is characterized in that: described preparation method is specially,
The first step, by wilsonii, the seed of cowherb, play both sides of the street, folium panacis japonici cum caule, stachyurus pith, radix glehniae, Radix Codonopsis, oyster and Chinese yam be ground into respectively powder, mix in proportion, pack in percolator, the ethanol that to add with respect to the determining alcohol of 4～6 times of mixture qualities be 75%～85%, soak at ambient temperature 20 hours～30 hours, open the valve of percolator, ethanolic solution is slowly oozed, the speed of oozing is 2～4ml per minute, collect drip, till ethanol drop to be oozed is colourless, concentrated, remove ethanolic solution, dry, pulverize, obtain the first powder;
Second step, mixes remaining component in proportion, adds the water with respect to 5～8 times of mixture qualities, boil 2～3 hours, filter, obtain the first filtrate, filter residue adds the water with respect to 2～4 times, mixture again, again boils 1～2 hour, filters, obtain the second filtrate, the first filtrate and the second filtrate are mixed, concentrated, except anhydrating, dry, pulverize, obtain the second powder;
The 3rd step, mixes the first powder and the second powder, obtains Traditional Chinese medicinal milk-increasing agent;
The 4th step, sends into corn silage, alfalfa hay, medical stone, sodium bicarbonate, salt, cottonseed, compound premix and described Traditional Chinese medicinal milk-increasing agent in batch mixer and is uniformly mixed in proportion, obtains fodder compound.
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| CN1739375A (en) * | 2004-11-19 | 2006-03-01 | 中国科学院东北地理与农业生态研究所 | A kind of milk cow Chinese herbal medicine cow galactic |
| CN101164429A (en) * | 2006-10-19 | 2008-04-23 | 天津市润拓生物技术有限公司 | Method for preparing traditional Chinese herb feed additive and its glagctogogue powder preparation |
| CN101856061A (en) * | 2010-05-28 | 2010-10-13 | 中国科学院东北地理与农业生态研究所 | Chinese medicinal herb lactation promoting pellet type additive for milk cows |
| CN102894189A (en) * | 2012-10-24 | 2013-01-30 | 刘向前 | Feed additive with functions of promoting lactation and improving meat quality |
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| JPS5763057A (en) * | 1980-09-29 | 1982-04-16 | Hiroe Ogawa | Cattle feed |
| KR101139810B1 (en) * | 2009-12-01 | 2012-04-30 | 전라남도 | Pig feed additive using korean medical herb for promoting milk productivity |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1739375A (en) * | 2004-11-19 | 2006-03-01 | 中国科学院东北地理与农业生态研究所 | A kind of milk cow Chinese herbal medicine cow galactic |
| CN101164429A (en) * | 2006-10-19 | 2008-04-23 | 天津市润拓生物技术有限公司 | Method for preparing traditional Chinese herb feed additive and its glagctogogue powder preparation |
| CN101856061A (en) * | 2010-05-28 | 2010-10-13 | 中国科学院东北地理与农业生态研究所 | Chinese medicinal herb lactation promoting pellet type additive for milk cows |
| CN102894189A (en) * | 2012-10-24 | 2013-01-30 | 刘向前 | Feed additive with functions of promoting lactation and improving meat quality |
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