CN105998333A - Traditional Chinese medicine capsules for treating rib fracture and preparing method - Google Patents
Traditional Chinese medicine capsules for treating rib fracture and preparing method Download PDFInfo
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- CN105998333A CN105998333A CN201610528589.1A CN201610528589A CN105998333A CN 105998333 A CN105998333 A CN 105998333A CN 201610528589 A CN201610528589 A CN 201610528589A CN 105998333 A CN105998333 A CN 105998333A
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- chinese medicine
- traditional chinese
- fracture
- chinese medicinal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
Abstract
The invention discloses traditional Chinese medicine capsules for treating rib fracture and a preparing method, and belongs to the technical field of traditional Chinese medicine. According to disease causes of rib fracture and the dialectical-therapy traditional Chinese medicine theory, the inventor selects traditional-Chinese-medicine fruits of fetid viburnum, roots of littleleaf dogwood, the whole grass of cucubalus baccifer, centranthera cochinchinensis, cape jasmine and psychotria serpens in clinical treatment practices, the traditional Chinese medicine is prepared into capsules with the traditional method, and clinical tests show that the curative effect is good, and particularly, the treating effect of the traditional Chinese medicine capsules on amygdalitis reaches 95%.
Description
Technical field
The invention belongs to pharmaceutical technology field, particularly to a kind of Chinese medicine treating fracture of rib
Capsule and preparation method.
Background technology
Fracture of rib in injury of chest wall more typically, because of respiratory movement, fracture end and local
Hematoma, to neural stimulation, makes chest have an intense pain, and with breathing, cough and increasing the weight of.Pain
Pain and thorax stability be damaged, make patient dare not eupnea, dare not cough and expectoration,
Thus cause carbon dioxide retention, lower respiratory tract secretions to block, the wet change of lung or pulmonary atelectasis,
So the reduction of the fracture is fixed and pain relieving plays an important role in the treatment of fracture of rib.Conventional
Analgesic techniques has oral anti-inflammatory agent, analgesic；During clinical practice, oral anti-inflammatory analgesic medicine
Rear pain all has and alleviates, but alleviates inconspicuous, when patient still suffers from air-breathing mostly chest pain increase the weight of,
The symptom of tachypnea, and few patients has gastrointestinal reaction；Topical lidocaine nerve hinders
Stagnant have preferable analgesic effect, but need to repeatedly apply, add misery when patient injects and
Medical worker's workload.We utilize China's abundant and the little Chinese herbal medicine resource of toxic and side effects,
In practical work, unceasing study and exploration, develop a kind of Chinese medicine treating fracture of rib
Capsule, this Chinese medicinal capsule is the most evident in efficacy, and toxic and side effects is little, and clinic is promoted should
With.
Summary of the invention
The invention provides a kind of Chinese medicinal capsule treating fracture of rib and preparation method；Rib
Fracture then local meridians are impaired, outside blood oozing from the body openings or subcuta neous tissue arteries and veins, hinder local QI-blood circulation, and stagnation of QI blood is tired,
Stagnation of QI and blood may bring about pain, therefore control suitable blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, antiinflammatory synthetism.
It is an object of the invention to be achieved through the following technical solutions, this treatment fracture of rib
Chinese medicinal capsule is made up of the Chinese medicine of following weight portion: Fructus Viburni Foetidi 80-100 part, Radix Corni Paucinervis
100-120 part, Herba Cucubali 60-90 part, Herba Centrantherae Cochinchinensis 30-40 part, Flos Micheliae Yunnanensis 20-30
Part, Ramulus et Folium Psychotriae Serpentis 40-50 part.
Preferred: Fructus Viburni Foetidi 90 parts, Radix Corni Paucinervis 110 parts, Herba Cucubali 70 parts, linum
Grass 35 parts, Flos Micheliae Yunnanensis 25 parts, Ramulus et Folium Psychotriae Serpentis 45 parts.
Preparation method: get the raw materials ready by prescription；Fructus Viburni Foetidi, Radix Corni Paucinervis, Herba Cucubali are inserted and carried
In extracting container, adding the water of 7-15 times of weight, extract 2-4 time, each 1-3h, merging carries
Taking liquid and filter, concentrated filtrate obtains the water extracted immersing paste of relative density 1.0-1.2；By Herba Centrantherae Cochinchinensis,
Flos Micheliae Yunnanensis, Ramulus et Folium Psychotriae Serpentis coarse pulverization are placed in extraction vessel, add 4-10 times of weight concentration and are
The ethanol solution of 60-80%, extracts 1-3 time, each 1-3h, and united extraction liquid filters, dense
Contracting filtrate obtains the alcohol-extracted extract of relative density >=1.02.
Described being extracted in ultrasound wave, electromagnetic wave or microwave extraction container completes.
Described concentrate for the one in concentrating under reduced pressure, membrance concentration or centrifugal concentrating or one with
On.
Described dry take lyophilization, drying under reduced pressure, drying with water bath, forced air drying,
Be spray-dried or microwave drying in one or more.
Purified Water extracted extract and the alcohol-extracted extract of described acquirement through 70 DEG C of drying under reduced pressure and are pulverized
Mixing, adds the edible corn starch meeting regulation according to a conventional method, makes capsule.
Fang Zhong: Fructus Viburni Foetidi heat-clearing and toxic substances removing, cough-relieving synthetism；Radix Corni Paucinervis scattered silt pain relieving, hemostasis connect
Bone；Herba Cucubali synthetism granulation promoting, stasis-dispelling and pain-killing；Herba Centrantherae Cochinchinensis detumescence dissipating blood stasis, hemostasis and pain-relieving；
Flos Micheliae Yunnanensis heat clearing and inflammation relieving；Ramulus et Folium Psychotriae Serpentis wind-damp dispelling, strengthening bone and muscle, alleviating pain and detumescence, removing toxic substances removing the necrotic tissue；
Fructus Viburni Foetidi, Radix Corni Paucinervis, Herba Cucubali are monarch drug；Herba Centrantherae Cochinchinensis is ministerial drug；Ramulus et Folium Psychotriae Serpentis is adjuvant drug；
Flos Micheliae Yunnanensis is for making medicine.
Detailed description of the invention
Embodiment one: weigh Fructus Viburni Foetidi 80g, Radix Corni Paucinervis 100g, Herba Cucubali 60g, recklessly
Fiber crops grass 30g, Flos Micheliae Yunnanensis 20g, Ramulus et Folium Psychotriae Serpentis 40g, by Fructus Viburni Foetidi, Radix Corni Paucinervis, Herba Cucubali
Inserting in extraction vessel, add the water of 12 times of weight, extract 3 times, each 2h, merging carries
Taking liquid and filter, concentrated filtrate obtains the water extracted immersing paste of relative density 1.05；By Herba Centrantherae Cochinchinensis, mountain
Flos Magnoliae, Ramulus et Folium Psychotriae Serpentis coarse pulverization are placed in extraction vessel, and adding 7 times of weight concentrations is 70%
Ethanol solution, extract 2 times, each 2h, united extraction liquid filter, concentrated filtrate obtains phase
Alcohol-extracted extract to density 1.1；By the water extracted immersing paste of described acquirement and alcohol-extracted extract through 70 DEG C
Drying under reduced pressure also pulverizes mixing, adds the edible corn starch meeting regulation according to a conventional method,
Make capsule.
Embodiment two: weigh Fructus Viburni Foetidi 90g, Radix Corni Paucinervis 110g, Herba Cucubali 70g, recklessly
Fiber crops grass 35g, Flos Micheliae Yunnanensis 25g, Ramulus et Folium Psychotriae Serpentis 45g, preparation method is with embodiment one.
Embodiment three: weigh Fructus Viburni Foetidi 100g, Radix Corni Paucinervis 120g, Herba Cucubali 90g,
Herba Centrantherae Cochinchinensis 40g, Flos Micheliae Yunnanensis 30g, Ramulus et Folium Psychotriae Serpentis 50g, preparation method is with embodiment one.
Toxicity test
1, laboratory animal cleaning grade healthy SD female rats 40, weight (200 ±
18) g, as chronic toxicity；The female white mice in cleaning grade health Kunming 30, body constitution
Amount (20 ± 2) g, as acute toxicological experiment.Feed with normal diet, commonly drink water, room temperature
Control in (24 ± 3) DEG C, humidity (50 ± 10) %, natural lighting.
The water extracted immersing paste that 2 Experimental agents are made by embodiment of the present invention two and alcohol-extracted extract
Through 70 DEG C of drying under reduced pressure and pulverize homomixture.
3, acute toxicological experiment is according to (Chinese medicine, researches on natural drugs registration service manual),
Select cleaning grade health Kunming female little from Mus 30, be randomly divided into 2 groups, Chinese drug-treated group and sky
White each 15 of matched group.Chinese drug-treated group is administered orally 10g/d (being equivalent to crude drug 210g) by adult normal
It is converted to the dosage of white mice, gavages Chinese medicine every day 1 time.Being administered volume is 1mL/20g body
Quality, mice dosage is equivalent to crude drug amount 1.037g.Blank group gives 1mL/20g
Weight 0.9% sodium chloride injection gavages.
4, chronic toxicity cleaning grade healthy SD female rats 40, is randomly divided into 4
Group, Normal group and capsule of the present invention little, in, each 10 of heavy dose of group.The most right
Give 1ml/20g weight 0.9% sodium chloride injection according to group, capsule of the present invention is little, in,
Heavy dose of group drug dose is the 5 of adult normal consumption, 15,50 times, i.e. 0.17g, 0.51g,
1.70g.It is gastric infusion.Every day 1 time, experimental period is 3 months.
5, result
Acute toxicological experiment white mice being administered in 7d without dead, to observation post administration mice outside
Normally, social behavior, reaction are all normal for sight, hair color, gloss, ingest, drain normally.7
Manually put to death dissection after d, observe its heart, liver, spleen, lungs, kidney, brain, ovum
Nest, uterus are showed no exception.Pathological examination: dye in single-minded Yihong of Lignum Sappan (HE), Chinese medicine
Group organ surface is smooth, and in order, cell size, form are normal in organizational structure arrangement, endochylema,
Karyon dyeing is clear, with blank group comparing difference not statistically significant (P ＞ 0.05).Meter
Calculating result display white mice is the 200 of adult to the Chinese medicinal capsule maximal tolerance times of the present invention
Times.
Chronic toxicity generality index, the Chinese medicinal capsule of the present invention is little, in, big agent
Amount group and the outward appearance of rats in normal control group, hair color, social behavior, zest etc. and to week
Collarette border, food, the comparing difference such as interest all unit'ss statistical significance (P ＞ 0.05) of water；4
(P ＜ 0.05) is increased before the experiment of weight the most relatively this group after group rat experiment, but after 4 groups of experiments
The equal not statistically significant of weight comparing difference (P ＞ 0.05)；
Blood cytology index, blood biochemical analysis index, each important organ coefficients comparison difference
All not statistically significants (P ＞ 0.05).Pathological examination after rat experiment, at 4 groups of rats after death
Important organ row staining pathologic section checks, HE dyes.The Chinese medicinal capsule group rat of the present invention
Organs and tissues structural arrangement is orderly, and cell size, form are normal, and the dyeing of endochylema, karyon is clear
Clear, with Normal group comparing difference not statistically significant (P ＞ 0.05).
The Chinese medicinal capsule of the present invention is the prescription of our clinical summary, through acute toxicological experiment
Confirm that the maximum tolerated dose of white mice is 200 times of adult's usual amounts, it is considered that little
More than 100 times of the clinical usual amounts that Mus maximum tolerated dose is equivalent to adult are safety；Slowly
Property toxicological experiment research confirm rat accept adult normal's consumption 5,15,50 times to
Under pharmaceutical quantities, each blood cytology index, blood biochemical analysis index compare with Normal group
The equal not statistically significant of difference is it was confirmed Drug safety of the present invention.
Clinical data
1, the physical data present invention treats the Chinese medicinal capsule of fracture of rib, selects the rib made a definite diagnosis
Bone fracture patient 120 example clinical observation, patient is randomly divided into treatment group and matched group two groups,
Treatment group 60 example, wherein male 30 example, women 30 example, age 12-58 year, average year
34 years old age；Matched group 60 example, wherein male 30 example, women 30 example, age 11-58
Year, 34 years old mean age.Treatment group and the course of disease of two groups of cases of matched group, symptom weight journey
Spend basically identical, without significant difference, there is comparability.
2, medicament selection treatment group takes Chinese medicinal capsule of the present invention, three times a day,
Each 3,8 days be 1 course for the treatment of, can fully recover 2-5 the course for the treatment of, the person of being in a bad way
Follow the doctor's advice the meal with wine amount of adding；Matched group takes bone-connecting pill, oral, a 3g, 2 times on the one,
The course for the treatment of is depending on the state of an illness.
3, efficacy determination is cured: above-mentioned symptom all disappears, and physical recovery is normal；Effective:
Above-mentioned symptom substantially alleviates, and health has taken a turn for the better；Effective: above-mentioned symptom has alleviated, body
Body is clearly better；Invalid: by above-mentioned symptom after treatment without alleviating or increasing the weight of.
4, during result selects the treatment group of medicine of the present invention, 36 examples are cured, effective 19 examples,
Effective 4 examples, invalid 1 example, cure rate 60%, total effective rate 98.33%；In matched group
Cure 24 examples, effective 17 examples, effective 6 examples, invalid 13 examples, cure rate 40%, always have
Efficiency 78.33%.Result above shows, the cure rate for the treatment of group and total effective rate apparently higher than
Matched group.
When 60 example patients for the treatment of group are followed up a case by regular visits to by inventor, wherein have 5 example patients to
We teach their another experience, after taking the Chinese medicinal capsule of the present invention, not only fracture
Obtain effective treatment, and the tonsillitis suffered from rehabilitation the most therewith, obtain this
After information, we utilize the Chinese medicinal capsule of the present invention immediately 40 examples to be suffered from tonsillitic trouble
Person carries out clinical trial.
Outcome measure is cured: tonsil inflammation, swelling and because tonsil inflammation is caused
The transference cures such as heating, pain, body immunity recovers normal；Take a turn for the better: above-mentioned symptom
Having alleviated, body immunity has recovered；Invalid: symptom is unchanged.
In therapeutic outcome 40 example patient, curing 30 examples, take a turn for the better 8 examples, invalid 2 examples, always
Effective percentage is 95%, and it is evident in efficacy.
Model case Liu, female, 13 years old, people from Linyi, Shandong.Patient plays and falls when running
Falling, cry and scream and do not stop, the head of a family sends to hospital, checks fracture of rib through X-ray film, uses this
Bright Chinese medicinal capsule is treated, and after using 2 courses for the treatment of, pain symptom has been alleviated, and is continuing with 2
After the individual course for the treatment of, transference cure, recovery from illness.
Jiang, man, 30 years old, people from Zhejiang.Fracture of rib on the left of patient's traffic accident, in underwent operative
After fixation for treatment, because of fracture site indolence, 3 months after operation, occur that joint motion hinders
Hinder, again go to a doctor, give Chinese medicinal capsule of the present invention treatment, after taking 1 course for the treatment of, symptom
Substantially alleviating, after being continuing with 2 courses for the treatment of, transference cure, joint motion recovers normal.
It follows that take the Chinese medicinal capsule of the present invention, not only to treatment fracture of rib curative effect
Significantly, and tonsillitis is had good therapeutical effect, clinic popularization and application.
Claims (2)
1. the Chinese medicinal capsule treating fracture of rib, it is characterised in that this Chinese medicinal capsule by with
The Chinese medicine of lower weight portion is made: Fructus Viburni Foetidi 80-100 part, Radix Corni Paucinervis 100-120 part, little quilt
Single grass 60-90 part, Herba Centrantherae Cochinchinensis 30-40 part, Flos Micheliae Yunnanensis 20-30 part, Ramulus et Folium Psychotriae Serpentis 40-50
Part.
A kind of Chinese medicinal capsule treating fracture of rib, its feature
It is that this Chinese medicinal capsule is made up of the Chinese medicine of following weight portion: Fructus Viburni Foetidi 90 parts, Radix Corni Paucinervis 110
Part, Herba Cucubali 70 parts, Herba Centrantherae Cochinchinensis 35 parts, Flos Micheliae Yunnanensis 25 parts, Ramulus et Folium Psychotriae Serpentis 45 parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610528589.1A CN105998333A (en) | 2016-06-27 | 2016-06-27 | Traditional Chinese medicine capsules for treating rib fracture and preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610528589.1A CN105998333A (en) | 2016-06-27 | 2016-06-27 | Traditional Chinese medicine capsules for treating rib fracture and preparing method |
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| Publication Number | Publication Date |
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| CN105998333A true CN105998333A (en) | 2016-10-12 |
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| CN201610528589.1A Pending CN105998333A (en) | 2016-06-27 | 2016-06-27 | Traditional Chinese medicine capsules for treating rib fracture and preparing method |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104800804A (en) * | 2015-04-29 | 2015-07-29 | 黄受显 | Medicament for quickly and efficiently treating fracture and preparation method of medicament |
| CN105395867A (en) * | 2015-12-06 | 2016-03-16 | 沂南攀峰骨科医院 | Traditional Chinese medicine bone-joining elixir for treating fracture and preparation method of traditional Chinese medicine bone-joining elixir |
| CN105663469A (en) * | 2016-03-05 | 2016-06-15 | 廉慧 | Chinese medicine external application agent for treating bone fractures and nursing method |
| CN105688054A (en) * | 2016-03-11 | 2016-06-22 | 李海芹 | Collateral dredging and blood activating soaking powder |
-
2016
- 2016-06-27 CN CN201610528589.1A patent/CN105998333A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104800804A (en) * | 2015-04-29 | 2015-07-29 | 黄受显 | Medicament for quickly and efficiently treating fracture and preparation method of medicament |
| CN105395867A (en) * | 2015-12-06 | 2016-03-16 | 沂南攀峰骨科医院 | Traditional Chinese medicine bone-joining elixir for treating fracture and preparation method of traditional Chinese medicine bone-joining elixir |
| CN105663469A (en) * | 2016-03-05 | 2016-06-15 | 廉慧 | Chinese medicine external application agent for treating bone fractures and nursing method |
| CN105688054A (en) * | 2016-03-11 | 2016-06-22 | 李海芹 | Collateral dredging and blood activating soaking powder |
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Application publication date: 20161012 |