CN105996026A - 一种防治虚火牙痛的甜味剂 - Google Patents
一种防治虚火牙痛的甜味剂 Download PDFInfo
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Abstract
本发明公开了一种防治虚火牙痛的甜味剂，其原料按重量份包括：其原料按重量份包括：甘草甜素5‑7份，罗汉果苷2‑4份，低聚果糖3‑5份，麦芽糖醇2‑4份，莱鲍迪苷A 70‑80份，甜菊苷10‑15份，索马甜6‑8份，中药提取物20‑30份；其中，中药提取物的原料按重量份包括：知母5‑7份，生地黄4‑6份，牡丹皮3‑5份，板蓝根9‑12份，山药6‑8份，黄精3‑5份，熟地黄4‑6份，灵芝草2‑4份，当归1‑3份，牛膝2‑4份，香附1‑3份，陈皮1‑2份，合欢皮1‑2份，远志1‑2份。本发明能清热泻火，解毒，消炎抗菌，滋阴补肝肾，益气健脾，调节身体机能，对治疗牙痛有很好的作用，且无毒副作用。
Description
技术领域
本发明涉及甜味剂技术领域，尤其涉及一种防治虚火牙痛的甜味剂。
背景技术
甜味剂是食品工业和医疗保健中不可或缺的重要原料，然而占据甜味剂市场居多的人工合成甜味剂可能对人体有致癌、治病的副作用，因而已被许多国家限制使用，而蔗糖的过多食用则导致越来越多的牙痛等疾病的发生。目前治疗牙痛，常用西药止痛或换牙，西药止痛不能根治，且具有毒副作用，换牙费用昂贵，因此需要提供一种新的甜味剂，既可以调节口感，又可以防治牙痛。
发明内容
基于背景技术存在的技术问题，本发明提出了一种防治虚火牙痛的甜味剂，本发明在清热泻火，解毒，消炎抗菌的同时，消肿止痛，滋阴补肝肾，益气健脾，补血生津，养心安神，调节身体机能，从病症和本质两方面同时作用，对治疗牙痛有很好的作用，标本兼治，且无毒副作用，稳定性好，无后苦味，口感好。
本发明提出的一种防治虚火牙痛的甜味剂，其原料按重量份包括：甘草甜素5-7份，罗汉果苷2-4份，低聚果糖3-5份，麦芽糖醇2-4份，莱鲍迪苷A 70-80份，甜菊苷10-15份，索马甜6-8份，中药提取物20-30份；
其中，中药提取物的原料按重量份包括：知母5-7份，生地黄4-6份，牡丹皮3-5份，板蓝根9-12份，山药6-8份，黄精3-5份，熟地黄4-6份，灵芝草2-4份，当归1-3份，牛膝2-4份，香附1-3份，陈皮1-2份，合欢皮1-2份，远志1-2份。
知母，别名为蒜辫子草、羊胡子根、地参、蚔母、连母等，为单子叶植物百合科知母的干燥根茎。味苦，性寒；入胃、肺、肾经。能清热泻火，生津润燥。用于外感热病，高热烦渴，肺热燥咳，骨蒸潮热，内热消渴，肠燥便秘。
生地黄，别名为生地、生地黄、鲜地黄、地黄、干生地、干地黄、大生地、细生地、怀生地、淮生地、生地炭等，为双子叶植物药玄参科植物地黄或怀庆地黄的根。味甘、苦，性寒；入心、肝、肾经。能清热，生津，滋阴，养血。用于阴虚发热，消渴，吐血，衄血，血崩，月经不调，胎动不安，阴伤便秘。生地黄还能增强免疫力。
牡丹皮，别名为丹皮、粉丹皮、木芍药、条丹皮、洛阳花、牡丹根皮、丹根等，为毛茛科植物牡丹干燥根皮。味辛、苦，性凉；入心、肝、肾经。能清热凉血，活血化瘀。用于温毒发斑，吐血衄血，夜热早凉，无汗骨蒸，经闭痛经，痈肿疮毒，跌扑伤痛。牡丹皮还具有抗菌抗炎的作用。
板蓝根，别名为大蓝根、大青根、靛青根、蓝靛根、靛根等，板蓝根分为北板蓝根和南板蓝根，北板蓝根来源为十字花科植物菘蓝和草大青的根；南板蓝根为爵床科植物马蓝的根茎及根。味苦，性寒；入胃、肝经。能清热解毒，凉血利咽。用于温毒发斑，舌绛紫暗，痄腮，喉痹，烂喉丹痧，大头瘟疫，丹毒，痈肿。板蓝根还具有抗菌抗病毒、提高免疫力的作用。
山药，别名为怀山药、淮山药、土薯、山薯、山芋、玉延等，为薯蓣科薯蓣属植物山药的根茎。味甘，性平；入脾、肺、肾经。能补脾养胃，生津益肺，补肾填精。用于脾虚食少，便溏久泻，肺虚喘咳，肾虚遗精，带下，尿频，虚热消渴。
黄精，别名为老虎姜、龙衔、太阳草、白及、兔竹、垂珠等，为百合科植物滇黄精、黄精或多花黄精的干燥根茎。味甘，性平；入肺、脾、肾经。能补气养阴，健脾，润肺，益肾。用于脾胃虚弱，体倦乏力，口干食少，肺虚燥咳，精血不足，内热消渴。黄精还具有抗菌抗病毒的作用。
熟地黄，别名为熟地等，为玄参科植物地黄的块根经加工炮制而成。通常以酒、砂仁或陈皮为辅料经反复蒸晒，至内外色黑油润，质地柔软粘腻。味甘，性温；入肝、肾经。能滋阴，补血。用于阴虚血少，腰膝痿弱，劳嗽骨蒸，遗精，崩漏，月经不调，消渴，溲数，耳聋，目昏。
灵芝草，别名为三秀、茵、芝等，为多孔菌科植物紫芝或赤芝的全株。味甘，性平；入心、脾、肺经。能益气健脾，养心安神，止咳平喘。主治虚劳羸弱，食欲不振，心悸怔忡，失眠健忘，肺虚咳喘；完心病心绞痛、高血压及高血脂症。灵芝草还具有抗菌的作用。
当归，别名为干归、马尾当归、秦哪、马尾归、云归、西当归、岷当归等，为伞形科植物当归的干燥根。味辛、甘，性寒；入心、脾、肝经。能补血和血，调经止痛，润燥滑肠。用于月经不调，经闭腹痛，症瘕结聚，崩漏；血虚头痛，眩晕，痿痹；肠燥便难，赤痢后重；痈疽疮窃，跌扑损伤。当归具有增强免疫力的作用。
牛膝，别名为怀牛膝、牛髁膝、山苋菜、对节草、红牛膝、杜牛膝、土牛膝等，为苋科植物牛膝的根。味酸、苦，性平；入肝、肾经。能补肝肾，强筋骨，逐瘀通经，引血下行。用于腰膝酸痛，筋骨无力，经闭症瘕，肝阳眩晕。牛膝还具有抗炎的作用。
香附，别名为莎草、香附子、雷公头、三棱草等，为莎草科植物莎草的干燥根茎。味辛，性寒；入三焦、肝经。能行气解郁，调经止痛。用于肝郁气滞，胸、胁、脘腹胀痛，消化不良，胸脘痞闷，寒疝腹痛，乳房胀痛，月经不调，经闭痛经。
陈皮，别名为橘皮、贵老、红皮、黄橘皮、广橘皮、新会皮、柑皮、广陈皮等，为芸香科植物橘及其栽培变种的成熟果皮。味辛、苦，性温；入肺、脾经。能理气健脾，燥湿化痰。用于胸脘胀满，食少吐泻，咳嗽痰多。
合欢皮，别名为合昏皮、夜合皮、合欢木皮、夜台皮等，为豆科植物合欢的干燥树皮。味甘，性平；入心、肝经。能安神解郁，活血消痈。用于心神不安；忧郁，不眠，内外痈疡，跌打损伤
远志，别名为小草、细草、小鸡腿、细叶远志、线茶、葽绕等，为远志科植物远志或卵叶远志的干燥根。味辛、苦，性温；入心、肾经。能宁心安神；祛痰开窍；解毒消肿。用于心神不安；惊悸失眠；健忘；惊痫；咳嗽痰多；痈疽发背；乳房肿痛。
优选地，其原料按重量份包括：甘草甜素5.5-6.5份，罗汉果苷2.5-3.5份，低聚果糖3.5-4.5份，麦芽糖醇2.5-3.5份，莱鲍迪苷A 73-77份，甜菊苷11-13份，索马甜6.5-7.5份，中药提取物22-28份。
优选地，其原料按重量份包括：甘草甜素6份，罗汉果苷3份，低聚果糖4份，麦芽糖醇3份，莱鲍迪苷A 75份，甜菊苷12份，索马甜7份，中药提取物25份。
优选地，中药提取物的原料按重量份包括：知母5.5-6.5份，生地黄4.5-5.5份，牡丹皮3.5-4.5份，板蓝根10-11份，山药6.5-7.5份，黄精3.5-4.5份，熟地黄4.5-5.5份，灵芝草2.5-3.5份，当归1.5-2.5份，牛膝2.5-3.5份，香附1.5-2.5份，陈皮1.2-1.8份，合欢皮1.3-1.7份，远志1.3-1.7份。
优选地，中药提取物的原料按重量份包括：知母6份，生地黄5份，牡丹皮4份，板蓝根10.5份，山药7份，黄精4份，熟地黄5份，灵芝草3份，当归2份，牛膝3份，香附2份，陈皮1.5份，合欢皮1.5份，远志1.5份。
优选地，在中药提取物的制备过程中，将知母、生地黄、牡丹皮、板蓝根、山药、黄精、熟地黄、灵芝草、当归、牛膝、香附、陈皮、合欢皮、远志粉碎混匀得到混合物；向混合物中加水、纤维素酶、木瓜蛋白酶，浸泡，升温，保温，灭酶，过滤取滤液，用陶瓷膜过滤得到透过液，用超滤膜过滤得到超滤透过液，真空干燥，粉碎得到中药提取物。
优选地，在中药提取物的制备过程中，将知母、生地黄、牡丹皮、板蓝根、山药、黄精、熟地黄、灵芝草、当归、牛膝、香附、陈皮、合欢皮、远志粉碎至60-80目，混匀得到混合物；向混合物中加水、纤维素酶、木瓜蛋白酶，浸泡15-25min，升温至50-54℃，保温1-2h，升温至93-97℃，保温50-60min灭酶，过滤取滤液，调节压力至0.22-0.24MPa，升温至50-52℃，用陶瓷膜过滤得到透过液，调节压力至0.66-0.68MPa，升温至45-48℃，用超滤膜过滤得到超滤透过液，真空干燥，粉碎至100-200目得到中药提取物。
优选地，在中药提取物的制备过程中，陶瓷膜的孔径为0.2-0.3μm。
优选地，在中药提取物的制备过程中，超滤膜的分子截留量为2000-3000D。
优选地，在中药提取物的制备过程中，混合物、水、纤维素酶、木瓜蛋白酶的重量比为1-2：15-25：0.01-0.02：0.03-0.04。
上述纤维素酶、木瓜蛋白酶可以从市场上购得。
甜菊糖苷是一种从菊科草本植物甜叶菊的叶片中提取的一种纯天然、高甜度、低热值的食品添加剂。甜菊糖苷具有降血压、降血糖、防龋齿的作用，其主要成分为甜菊苷和莱鲍迪苷A。莱鲍迪苷A在甜度、理化性质等方面优于其他甜菊糖苷，而且口感接近蔗糖，是蔗糖的极佳替代品；甜菊苷可以用来做甜味剂，但是具有后苦味。
本发明选用的甘草甜素具有低热能，安全无毒和较强的医疗保健功效，高血压、肥胖症、糖尿病、心脏病患者均可食用；罗汉果苷甜度高，热值低，无不适后味，并能清热解毒；低聚果糖既保持了蔗糖的纯正甜味性质，又比蔗糖甜味清爽，还具有调节肠道菌群，增殖双歧杆菌，促进钙的吸收，调节血脂，免疫调节，抗龋齿等保健功能；麦芽糖醇极难形成龋齿，能促进钙吸收、促进胰岛素分泌，抑制体内脂肪过多积累；索马甜是天然的高倍甜味剂，后甜味较长；甘草甜素、罗汉果苷、低聚果糖、麦芽糖醇、莱鲍迪苷A、甜菊苷、索马甜相互配合，可以改善本发明的口感，增加本发明预防龋齿的作用；以知母、生地黄、牡丹皮、板蓝根为君药，清热泻火，解毒，生津滋阴，并且能消炎抗菌，增强机体免疫力，增强对牙痛的治疗作用；以山药、黄精、熟地黄、灵芝草、当归、牛膝为臣药，辅助君药进一步抗菌消炎，增强免疫力的同时，滋阴补肝肾，益气健脾，补血生津，养心安神，调节身体机能，增强对牙痛的防治；以香附、陈皮、合欢皮、远志为使药，理气健脾，安神解郁，解毒消肿，止痛；上述诸药相互配合，在清热泻火，解毒，消炎抗菌的同时，消肿止痛，滋阴补肝肾，益气健脾，补血生津，养心安神，调节身体机能，从病症和本质两方面同时作用，对治疗牙痛有很好的作用，标本兼治，且无毒副作用；上述诸药配合甘草甜素、罗汉果苷、低聚果糖、麦芽糖醇、莱鲍迪苷A、甜菊苷、索马甜，可以进一步增加本发明预防和治疗牙痛的作用，且可以改善中药提取物造成的不良口感，保持本发明的口感。
具体实施方式
下面，通过具体实施例对本发明的技术方案进行详细说明。
实施例1
一种防治虚火牙痛的甜味剂，其原料按重量份包括：甘草甜素5份，罗汉果苷4份，低聚果糖3份，麦芽糖醇4份，莱鲍迪苷A 70份，甜菊苷15份，索马甜6份，中药提取物30份；
其中，中药提取物的原料按重量份包括：知母5份，生地黄6份，牡丹皮3份，板蓝根12份，山药6份，黄精5份，熟地黄4份，灵芝草4份，当归1份，牛膝4份，香附1份，陈皮2份，合欢皮1份，远志2份。
实施例2
一种防治虚火牙痛的甜味剂，其原料按重量份包括：甘草甜素7份，罗汉果苷2份，低聚果糖5份，麦芽糖醇2份，莱鲍迪苷A 80份，甜菊苷10份，索马甜8份，中药提取物20份；
其中，中药提取物的原料按重量份包括：知母7份，生地黄4份，牡丹皮5份，板蓝根9份，山药8份，黄精3份，熟地黄6份，灵芝草2份，当归3份，牛膝2份，香附3份，陈皮1份，合欢皮2份，远志1份。
实施例3
一种防治虚火牙痛的甜味剂，其原料按重量份包括：甘草甜素5.5份，罗汉果苷3.5份，低聚果糖3.5份，麦芽糖醇3.5份，莱鲍迪苷A 73份，甜菊苷13份，索马甜6.5份，中药提取物28份；
其中，中药提取物的原料按重量份包括：知母5.5份，生地黄5.5份，牡丹皮3.5份，板蓝根11份，山药6.5份，黄精4.5份，熟地黄4.5份，灵芝草3.5份，当归1.5份，牛膝3.5份，香附1.5份，陈皮1.8份，合欢皮1.3份，远志1.7份；
在中药提取物的制备过程中，将知母、生地黄、牡丹皮、板蓝根、山药、黄精、熟地黄、灵芝草、当归、牛膝、香附、陈皮、合欢皮、远志粉碎至60目，混匀得到混合物；向混合物中加水、纤维素酶、木瓜蛋白酶，浸泡25min，升温至50℃，保温2h，升温至93℃，保温60min灭酶，过滤取滤液，调节压力至0.22MPa，升温至52℃，用孔径为0.2μm陶瓷膜过滤得到透过液，调节压力至0.68MPa，升温至45℃，用分子截留量为3000D超滤膜过滤得到超滤透过液，真空干燥，粉碎至100目得到中药提取物，其中，混合物、水、纤维素酶、木瓜蛋白酶的重量比为2：15：0.02：0.03。
实施例4
一种防治虚火牙痛的甜味剂，其原料按重量份包括：甘草甜素6.5份，罗汉果苷2.5份，低聚果糖4.5份，麦芽糖醇2.5份，莱鲍迪苷A 77份，甜菊苷11份，索马甜7.5份，中药提取物22份；
其中，中药提取物的原料按重量份包括：知母6.5份，生地黄4.5份，牡丹皮4.5份，板蓝根10份，山药7.5份，黄精3.5份，熟地黄5.5份，灵芝草2.5份，当归2.5份，牛膝2.5份，香附2.5份，陈皮1.2份，合欢皮1.7份，远志1.3份；
在中药提取物的制备过程中，将知母、生地黄、牡丹皮、板蓝根、山药、黄精、熟地黄、灵芝草、当归、牛膝、香附、陈皮、合欢皮、远志粉碎至80目，混匀得到混合物；向混合物中加水、纤维素酶、木瓜蛋白酶，浸泡15min，升温至54℃，保温1h，升温至97℃，保温50min灭酶，过滤取滤液，调节压力至0.24MPa，升温至50℃，用孔径为0.3μm陶瓷膜过滤得到透过液，调节压力至0.66MPa，升温至48℃，用分子截留量为2000D超滤膜过滤得到超滤透过液，真空干燥，粉碎至200目得到中药提取物，其中，混合物、水、纤维素酶、木瓜蛋白酶的重量比为1：25：0.01：0.04。
实施例5
一种防治虚火牙痛的甜味剂，其原料按重量份包括：甘草甜素6份，罗汉果苷3份，低聚果糖4份，麦芽糖醇3份，莱鲍迪苷A 75份，甜菊苷12份，索马甜7份，中药提取物25份；
其中，中药提取物的原料按重量份包括：知母6份，生地黄5份，牡丹皮4份，板蓝根10.5份，山药7份，黄精4份，熟地黄5份，灵芝草3份，当归2份，牛膝3份，香附2份，陈皮1.5份，合欢皮1.5份，远志1.5份；
在中药提取物的制备过程中，将知母、生地黄、牡丹皮、板蓝根、山药、黄精、熟地黄、灵芝草、当归、牛膝、香附、陈皮、合欢皮、远志粉碎至70目，混匀得到混合物；向混合物中加水、纤维素酶、木瓜蛋白酶，浸泡20min，升温至52℃，保温1.5h，升温至95℃，保温55min灭酶，过滤取滤液，调节压力至0.23MPa，升温至51℃，用孔径为0.25μm陶瓷膜过滤得到透过液，调节压力至0.67MPa，升温至47℃，用分子截留量为2000D超滤膜过滤得到超滤透过液，真空干燥，粉碎至150目得到中药提取物，其中，混合物、水、纤维素酶、木瓜蛋白酶的重量比为3：40：0.03：0.07。
试验例1
随机抽取具有：牙齿隐隐微痛，牙龈微红、微肿，久则牙龈萎缩、牙齿松动，伴有心烦失眠、眩晕，舌红嫩，脉细数症状的患者50例，将实施例5用水冲服，每次5g，每天两次，连续服用40天。治疗结果为：在50例患者中，痊愈45例，有效4例，无效1例，治愈率为90％，总有效率为98％，其中，症状全部消失为痊愈；症状基本消失或明显缓解为有效；症状无明显改善为无效。
由上述结果可以看出，本发明治疗虚火牙痛效果好。
以上所述，仅为本发明较佳的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明揭露的技术范围内，根据本发明的技术方案及其发明构思加以等同替换或改变，都应涵盖在本发明的保护范围之内。
Claims (10)
1.一种防治虚火牙痛的甜味剂，其特征在于，其原料按重量份包括：甘草甜素5-7份，罗汉果苷2-4份，低聚果糖3-5份，麦芽糖醇2-4份，莱鲍迪苷A 70-80份，甜菊苷10-15份，索马甜6-8份，中药提取物20-30份；
其中，中药提取物的原料按重量份包括：知母5-7份，生地黄4-6份，牡丹皮3-5份，板蓝根9-12份，山药6-8份，黄精3-5份，熟地黄4-6份，灵芝草2-4份，当归1-3份，牛膝2-4份，香附1-3份，陈皮1-2份，合欢皮1-2份，远志1-2份。
2.根据权利要求1所述防治虚火牙痛的甜味剂，其特征在于，其原料按重量份包括：甘草甜素5.5-6.5份，罗汉果苷2.5-3.5份，低聚果糖3.5-4.5份，麦芽糖醇2.5-3.5份，莱鲍迪苷A 73-77份，甜菊苷11-13份，索马甜6.5-7.5份，中药提取物22-28份。
3.根据权利要求1或2所述防治虚火牙痛的甜味剂，其特征在于，其原料按重量份包括：甘草甜素6份，罗汉果苷3份，低聚果糖4份，麦芽糖醇3份，莱鲍迪苷A 75份，甜菊苷12份，索马甜7份，中药提取物25份。
4.根据权利要求1-3任一项所述防治虚火牙痛的甜味剂，其特征在于，中药提取物的原料按重量份包括：知母5.5-6.5份，生地黄4.5-5.5份，牡丹皮3.5-4.5份，板蓝根10-11份，山药6.5-7.5份，黄精3.5-4.5份，熟地黄4.5-5.5份，灵芝草2.5-3.5份，当归1.5-2.5份，牛膝2.5-3.5份，香附1.5-2.5份，陈皮1.2-1.8份，合欢皮1.3-1.7份，远志1.3-1.7份。
5.根据权利要求1-4任一项所述防治虚火牙痛的甜味剂，其特征在于，中药提取物的原料按重量份包括：知母6份，生地黄5份，牡丹皮4份，板蓝根10.5份，山药7份，黄精4份，熟地黄5份，灵芝草3份，当归2份，牛膝3份，香附2份，陈皮1.5份，合欢皮1.5份，远志1.5份。
6.根据权利要求1-5任一项所述防治虚火牙痛的甜味剂，其特征在于，在中药提取物的制备过程中，将知母、生地黄、牡丹皮、板蓝根、山药、黄精、熟地黄、灵芝草、当归、牛膝、香附、陈皮、合欢皮、远志粉碎混匀得到混合物；向混合物中加水、纤维素酶、木瓜蛋白酶，浸泡，升温，保温，灭酶，过滤取滤液，用陶瓷膜过滤得到透过液，用超滤膜过滤得到超滤透过液，真空干燥，粉碎得到中药提取物。
7.根据权利要求6所述防治虚火牙痛的甜味剂，其特征在于，在中药提取物的制备过程中，将知母、生地黄、牡丹皮、板蓝根、山药、黄精、熟地黄、灵芝草、当归、牛膝、香附、陈皮、合欢皮、远志粉碎至60-80目，混匀得到混合物；向混合物中加水、纤维素酶、木瓜蛋白酶，浸泡15-25min，升温至50-54℃，保温1-2h，升温至93-97℃，保温50-60min灭酶，过滤取滤液，调节压力至0.22-0.24MPa，升温至50-52℃，用陶瓷膜过滤得到透过液，调节压力至0.66-0.68MPa，升温至45-48℃，用超滤膜过滤得到超滤透过液，真空干燥，粉碎至100-200目得到中药提取物。
8.根据权利要求6所述防治虚火牙痛的甜味剂，其特征在于，在中药提取物的制备过程中，陶瓷膜的孔径为0.2-0.3μm。
9.根据权利要求6所述防治虚火牙痛的甜味剂，其特征在于，在中药提取物的制备过程中，超滤膜的分子截留量为2000-3000D。
10.根据权利要求6所述防治虚火牙痛的甜味剂，其特征在于，在中药提取物的制备过程中，混合物、水、纤维素酶、木瓜蛋白酶的重量比为1-2：15-25：0.01-0.02：0.03-0.04。
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| CN105053954A (zh) * | 2015-08-14 | 2015-11-18 | 蚌埠市华东生物科技有限公司 | 一种口感好降血糖甜菊糖苷甜味剂 |
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| 巢建国等: "《中药资源学》", 31 August 2014, 中国医药科技出版社 * |
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| CN107156771A (zh) * | 2017-05-04 | 2017-09-15 | 广东冠龙生物科技有限公司 | 一种无能量甜味剂 |
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