CN105995720A - 一种酵素莱阳梨膏及其制备方法和应用 - Google Patents
一种酵素莱阳梨膏及其制备方法和应用 Download PDFInfo
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Abstract
一种酵素莱阳梨膏及其制备方法和应用。本发明公开一种莱阳梨膏，包括7—14斤的莱阳梨与1份的中药汤剂低温发酵后低温负压蒸馏浓缩而成，其特征在于：所述的1份中药汤剂由如下重量份的药材熬制而成：甘草、干姜、大枣、荞麦、葛根、山楂、乌梅、藿香、砂仁、茯苓、枸杞子、菊花、罗汉果各8‑13克，胖大海4‑8克，白茅根、百合各2‑5克，桔梗5‑9克。本发明还公开这种莱阳梨膏的制备方法，与现有技术相比，本梨膏活性植物酶不仅具有润肺止咳，清咽利喉，降火生津，和胃化痰。美容养颜。防治雾霾综合征，解毒，降血脂，降血压，降胆固醇。更能有效防治癌症，肝肾等疾病。
Description
技术领域
本发明涉及中医药技术领域，尤其涉及一种酵素莱阳梨膏及其制备方法和应用。
背景技术
莱阳梨不仅是一种美味的水果，它还可以加工成为一种中药梨膏。莱阳梨独含有天然原儿茶素是其地方梨没有的。儿茶素具有控制肥胖，防治心血管疾病预防癌症等功效,莱阳梨具养阴。润肺。止咳。去痰，生津，降火等功效。
现有的梨膏同样也具有具有养阴、润肺、止咳、祛痰、生津、降火等功效，可用于治疗因热燥伤津所致的咳嗽喘促、痰涎粘稠、胸中热闷、口燥咽干、烦躁声哑，特别是对于肺热、久咳、伤阴者，疗效更加的明显。但目前对于莱阳梨中的儿茶素有效成分如何充分保留研究不多，同时如何时莱阳梨衍生出对人体有益的脂肪酶、蛋白酶、纤维酶、淀粉酶为主复合酶更没有相关报道，也没有莱阳梨膏治疗心脑血管疾病以及预防癌症方面的报道。
发明内容
为克服现有技术的不足，本发明公开一种不仅具有清肺、润燥、美容、养颜功能，还具有降低总胆固醇，降低低密度脂蛋白胆固醇，降低血清甘油三酯，降低动脉粥样硬化指数，升高高密度脂蛋白胆固 醇的莱阳梨膏及其制备方法。本发明要求保护这种莱阳梨膏在治疗心脑血管病和防治癌症中的应用。
这种酵素莱阳梨膏，包括7—14斤的莱阳梨与1份的中药汤剂低温发酵后低温负压蒸馏浓缩而成，其特征在于：所述的1份中药汤剂由如下重量份的药材熬制而成：甘草、干姜、大枣、荞麦、葛根、山楂、乌梅、藿香、砂仁、茯苓、枸杞子、菊花、罗汉果各8-13克，胖大海4-8克，白茅根、百合各2-5克，桔梗5-9克。
作为优选方案，所述的1份中药汤剂由如下重量份的药材熬制而成：甘草、干姜、大枣、荞麦、葛根、山楂、乌梅、藿香、砂仁、茯苓、枸杞子、菊花、罗汉果各10克，胖大海5克，白茅根、百合各3克，桔梗7克。
这种酵素莱阳梨膏的制备方法，其特征在于包含如下步骤：
A将莱阳梨洗净、称重、全梨隔水蒸透使梨子不氧化变质；
B将蒸透的全梨用机械或手工加压破碎成浆；
C中药汤剂的熬制：将甘草、干姜、大枣、荞麦、葛根、山楂、乌梅、藿香、砂仁、茯苓、枸杞子、菊花、罗汉果、胖大海、白茅根、百合、桔梗加入到2000-4000克水中，浸泡40至60分钟；
D将步骤B的梨浆和步骤C的药水混合物一同加热100摄氏度熬合30分钟；
E凉至40摄氏度时，滤去药渣，药液中加入红曲米充分搅拌形成 酵液，比例为每一百斤药液加红曲米6斤；
F酵液密封发酵90-180天；
G以丝布或2000目筛网过滤去渣；
H加热至40摄氏度，负压蒸馏水份，糖度达80度时成膏出成品。
加热至40摄氏度而不是更高用于确保活性酶活性。
服用方法：对于养生保健者，每天饭前10ml酵素莱阳梨膏匀兑200ml水冲服；身体疲惫劳累无力者可直接服原液，能喝多少喝多少；身体很虚或患有严重疾病者以及儿童每次只能10滴以下原液匀兑200ml水冲服。
莱阳梨所含的儿茶素-----儿茶酚超过其它地方的梨，其含量与普洱茶不分上下儿茶素具有明显的酚的特性，能使重金属和蛋白质沉淀，所以，是一种酚性物。酚性物由于能使蛋白质沉淀，就具有大小不等的把生皮鞣成革的性能，因此也称为鞣质或单宁物质。儿茶素与一些典型的植物单宁(五倍子单宁等)相比，鞣革的性能是较弱的。儿茶素是多羟基黄烷-3-酚之总称，但有时则特指(+)儿茶素。广泛分布于植物界，在Acacia catechu、gambir树皮中与单宁共同大量存在。单宁的作用很弱，但通过加热和酸等处理容易重合形成单宁。2，3位由于含不整齐的碳原子而具有非对应异构体。
儿茶素作为鞣质的前体，广泛分布于植物中，且常与相对应的黄酮类化合物共存。儿茶素的分子中有两个手性(见手征性)碳原子,故有四种立体异构体:(+)－儿茶素、(-)－儿茶素、(+)－表儿茶素、(-) －表儿茶素。
儿茶素类中其他化合物如没食子儿茶素(又称茶儿茶素)等也都有类似的立体异构体，它们在热水溶液中容易发生差向异构化作用或变旋作用(见旋光异构)而相互转化。儿茶素类在植物体中可游离存在，或与糖(见碳水化合物)结合成苷或与有机酸缩合(见缩合反应)为酯类而存在。
儿茶素主要分为四种：①表儿茶素(Epicatechin EC)；②表没食子儿茶素(Epigallocatechin EGC)；③表儿茶素没食子酸酯(Epicatechin gallate ECG)；④表没食子儿茶素没食子酸酯(Epigallocatechin gallate EGCG)。[1]
莱阳梨儿茶素及其酯类衍生物，主要有(-)－表儿茶素、(-)－表没食子儿茶素、(-)－表儿茶素-3－没食子酸酯、(-)－表没食子儿茶素-3－没食子酸酯等。这些化合物分子小，溶于水成真溶液，在溶液中可被氧化而自身缩合为不同程度的缩合产物，从水溶性鞣质到水不溶性鞣红。
国际生命科学学会中国办事处等主办的中国控制中心性肥胖科学大会已召开，儿茶素对人体脂肪代谢以及脂肪分布，特别是内脏脂肪的减少有着明显的作用。
儿茶素可降低心血管疾病和癌症风险，主要是因为儿茶素含有丰富的类黄酮物质，特别是儿茶素类。已经有大量的临床实验证明，儿茶素具有细胞调节作用以及抗氧化功能。儿茶素是一类具有高活性 的类黄酮的总称。联合利华针对儿茶素功效进行的两个临床实验中发现，在不改变饮食和身体活动的前提下，轻度超重的中国健康男性与女性连续90天饮用高儿茶素含量绿茶后，体重、腰围和内脏脂肪都显著减少，绿茶中的儿茶素可能对人体脂肪分布，特别是腹部脂肪分布产生特定的有益影响，它对控制中心性肥胖具有一定的效果。
儿茶素具有防治心血管疾病、预防癌症等多种功能。右旋儿茶精还有降低毛细血管的通透性、止泻、止血、抗病毒、杀真菌、抑制ACE及预防胃溃疡等多种作用。
清除自由基：儿茶素是天然的油脂抗氧化剂，抗氧化活性甚至比维他命E还。并且可以清除人体产生的自由基，以保护细胞膜。
延缓老化：因为有清除自由基的功用，所以可以减缓衰老。
预防蛀牙：因为儿茶素类可以明显地减少牙菌斑以及减缓牙周病。
改变肠道微生物的分布：儿茶素类可以抑制人体致病菌(如肉毒杆菌)，同时又不伤害有益菌(如乳酸菌)的繁衍，所以有整肠的功能。
抗菌作用：可以抑制引起人类皮肤病的病菌，并且对治疗湿疹有很好的疗效。
除臭：儿茶素可以除去甲硫醇的臭味，所以可以去除抽烟者的口臭，并且减轻猪、鸡以及人排泄物的臭味(因为儿茶素可以抵抗人 体肠道内产生恶臭的细菌)。
其它：还有一些研究显示儿茶素还具有抑制血压(可降低舒张压与收缩压)及血糖(抑制醣分解酵素)、降低血中胆固醇及低密度脂蛋白(LDL)，并增加高密度脂蛋白(HDL)的量(日本用来做低胆固醇蛋)、抗辐射以及紫外线(美国已做成预防紫外线的化妆品)、抗突变(在微生物已获得证实，但还没有人体试验的报告)等功用。
一般人在日常保健中也可以多食水果绿茶作为抗癌保健，根据国内肿瘤科颜荣郎医师在其所著「抗癌就像减肥」书中介绍，梨。苹果。香蕉。绿茶中含有丰富活性成份儿茶素，二次大战受到广岛辐射污染的日本人，在移居绿茶产区并长期饮用后，健康状况及寿命都比未移居的人好；而欧洲也有研究证实儿茶素对受到辐射照射的小白鼠有防护效果。儿茶素中的Epigallocatechin gallate(EGCG)成份，具有很强的活性氧清除功能，能预防脂质、蛋白质或基因的过氧化。同时，儿茶素也可启动多种解毒酵素，可以防癌、缓解慢性发炎或老化。
颜荣郎医师归纳儿茶素四大抗癌特点，包括：诱导癌细胞凋零、促进癌干细胞凋亡、抑制发炎因子NF-kB，以及提高自然杀手细胞抗癌免疫力。
一般人在日常保健中也可以多加透过食用梨，苹果，发酵茶作为抗癌保健，根据国内肿瘤科颜荣郎医师在其所著「抗癌就像减肥」书中介绍，水果中含有丰富活性成份儿茶素，二次大战受到广岛辐射污染的日本人，在移居绿茶产区并长期饮用后，健康状况及寿命都比未移居的人好；而欧洲也有研究证实儿茶素对受到辐射照射的小白鼠有防护 效果。
儿茶素中的Epigallocatechin gallate(EGCG)成份，具有很强的活性氧清除功能，能预防脂质、蛋白质或基因的过氧化。同时，儿茶素也可启动多种解毒酵素，可以防癌、缓解慢性发炎或老化。
颜荣郎医师归纳儿茶素四大抗癌特点，包括：诱导癌细胞凋零、促进癌干细胞凋亡、抑制发炎因子NF-kB，以及提高自然杀手细胞抗癌免疫力。
红曲米是中国独特的传统食品，距今已经有千年历史，早在明代药学家李时珍所著《本草纲目》中，就记载红曲可做为中医药材，认为红曲营养丰富、无毒无害、具有健脾消食、活血化淤的特殊功效。历来被视为安全性高的食品补充剂。
红曲是寄生在红曲米上，发酵提取的活性生物菌。70年代日本科学家远藤根据《本草纲目》上记载红曲的“活血”功效的启示，从红曲营养液中分离出优良的6种含胆固醇抑制剂和甘油三酯分解剂的红曲菌，被命名为“莫纳可林”即“他汀类”，此后30多年来，红曲米提取的“他汀”被世界医学界公认为最好的降脂药，在临床上大量使用。
2002年，震惊世界的生物领域重大发明，红曲中的降糖、降压、抗癌成分(GABA-GLUCOSAMINE)通过发酵提取，在原来6种高纯度他汀的基础上合成“红曲酵素(Monacolin-R)，经大量的临床试验，这种复合酵素不仅保留了生物他丁的降脂功效，而且它的降血压效果堪比任何药物，《药日新闻》撰文品论，红曲酵素的出现，将开辟降压药新时代。
随后的6年，5万名高血压患者临床运用证实：“红曲酵素”对调理器官微血循环、帮助血液进行重新分配，迅速降压，修复受损心脑肝肾作用显著。而且“红曲酵素”降压同时、养心、护脑、清肝、活肾的功效，达到了降压药的顶峰。“红曲酵素”也被世界医学界誉为“可以媲美青霉素的旷世发现”。
红曲酵素(Monacolin-R)不仅能彻底替代西药降压，而且无任何副作用，100％的一期高血压患者经过3个月治疗，就能做到终身不用服药；80％的二期高血压患者，经过半年的治疗，实现了血压平稳，治疗心脑疾病，防止心脑疾病恶化，5天服用1粒药；70％的三期高血压患者，经过1年的治疗，血压平稳，冠心病、心绞痛、心梗、脑梗、脑出血得到彻底康复，防止心脑猝死。
近代医学研究报告认为，红曲具有降血压、降血脂的作用，所含红曲霉素K可阻止生成胆固醇；红曲米外皮呈紫红色，内心红色，微有酸味，味淡，它对蛋白质有很强的着色力，因此常常作为食品染色色素；红曲米与化学合成红色素相比，具有无毒、安全的优点，而且还有健脾消食、活血作用。
本世纪七十年代末，日本学者远藤章教授等人从红曲中分离出一种能降低人体血液中胆固醇的有效物质，并且命名为Monacolin-k,从此给功能性红曲有调节血脂作用提供了科学的依据。采用中国古典发酵法生产的红曲酸，经过临床试验，疗效显著，既安全又无副作用。
甘草：补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药。用于脾胃虚弱。倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性。
干姜：温中散寒，回阳通脉，温肺化饮。
大枣：补中益气，养血安神。用于脾虚食少，乏力便溏，妇人脏躁。
荞麦：开胃宽肠，下气消积。治绞肠痧，肠胃积滞，慢性泄泻，噤口痢疾，赤游丹毒，痈疽发背，瘰疬，汤火灼伤。
葛根：解肌退热，透疹，生津止渴，升阳止泻。
山楂：消食健胃，行气散瘀，化浊降脂。用于肉食积滞，胃脘胀满，泻痢腹痛，瘀血经闭，产后瘀阻，心腹刺痛，胸痹心痛，疝气疼痛，高脂血症。焦山楂消食导滞作用增强。用于肉食积滞，泻痢不爽。
乌梅敛肺，涩肠，生津，安蛔。用于肺虚久咳，久泻久痢，虚热消渴，蛔厥呕吐腹痛。
藿香：祛暑解表；化湿和胃。主夏令感冒；寒热头痛；胸脘痞闷；呕吐泄泻；妊娠呕吐；鼻渊；手；足癣。
砂仁：化湿开胃，温脾止泻，理气安胎。用于湿浊中阻，脘痞不饥，脾胃虚寒，呕吐泄泻，妊娠恶阻，胎动不安。
茯苓利水渗湿，健脾，宁心。用于水肿尿少，痰饮眩悸，脾虚食少，便溏泄泻，心神不安，惊悸失眠。
枸杞子：滋补肝肾，益精明目。用于虚劳精亏，腰膝酸痛，眩晕耳鸣，阳萎遗精，内热消渴，血虚萎黄，目昏不明。
菊花：散风清热，平肝明目，清热解毒。用于风热感冒，头痛眩晕，目赤肿痛，眼目昏花，疮痈肿毒。
罗汉果：清热润肺，利咽开音，滑肠通便。用于肺热燥咳，咽痛失音，肠燥便秘。
胖大海：清热润肺，利咽解毒，润肠通便。用于肺热声哑，干咳无痰，咽喉干痛，热结便闭，头痛目赤。
白茅根：凉血止血，清热利尿。用于血热吐血，衄血，尿血，热病烦渴，黄疸，水肿，热淋涩痛；急性肾炎水肿。
百合：养阴润肺，清心安神。用于阴虚久咳，痰中带血，虚烦惊悸，失眠多梦，精神恍惚
桔梗：宣肺，利咽，祛痰，排脓。用于咳嗽痰多，胸闷不畅，咽痛音哑，肺痈吐脓。
莱阳梨配伍几味中药通过红曲米发酵经过分离，低温蒸馏，浓缩等技术。使莱阳梨产生以脂肪酶、蛋白酶、纤维酶、淀粉酶为主复合酶。
红曲米功能主治：活血化瘀健脾消食。用红曲米发酵后产生大量复合酶有非常强大降低总胆固醇，降低低密度脂蛋白胆固醇，降低血清甘油三酯，降低动脉粥样硬化指数，升高高密度脂蛋白胆固醇的显著疗效。并能有效治疗冠心病，脑中风。等心脑血管疾病及高血脂，高血压的相关疾病。以及肾病综合征及脂肪肝，癌症等疾病。红曲米发酵后可产生大量辅酶Q10，辅酶Q10又名癸烯醌，是细胞代谢及细胞呼吸的激活剂，能改善线粒体呼吸功能，促进氧化磷酸反应，它本身又是细胞自身产生的天然氧化剂。能抑制线粒体的过氧化，有保护生物膜完整性的功能。对免疫有非特异的增强作用，能提高吞噬细胞的吞噬率，增加抗体产生改善T细胞功能。抑治癌症。
与现有技术相比，本梨膏活性植物酶不仅具有润肺止咳，清咽利喉，降火生津，和胃化痰。美容养颜。防治雾霾综合征，解毒，降血脂，降血压，降胆固醇。更能有效防治癌症，肝肾等疾病。
具体实施方式
实施例1：一种酵素莱阳梨膏，包括7斤的莱阳梨与1份的中药汤剂低温发酵后低温负压蒸馏浓缩而成，所述的1份中药汤剂由如下重量份的药材熬制而成：甘草、干姜、大枣、荞麦、葛根、山楂、乌梅、藿香、砂仁、茯苓、枸杞子、菊花、罗汉果各8克，胖大海4克，白茅根、百合各2克，桔梗5克。
实施例2：一种酵素莱阳梨膏，包括14斤的莱阳梨与1份的中药汤剂低温发酵后低温负压蒸馏浓缩而成，所述的1份中药汤剂由如 下重量份的药材熬制而成：甘草、干姜、大枣、荞麦、葛根、山楂、乌梅、藿香、砂仁、茯苓、枸杞子、菊花、罗汉果各13克，胖大海8克，白茅根、百合各5克，桔梗9克。
实施例3：一种酵素莱阳梨膏，包括10斤的莱阳梨与1份的中药汤剂低温发酵后低温负压蒸馏浓缩而成，所述的1份中药汤剂由如下重量份的药材熬制而成：甘草、干姜、大枣、荞麦、葛根、山楂、乌梅、藿香、砂仁、茯苓、枸杞子、菊花、罗汉果各10克，胖大海5克，白茅根、百合各3克，桔梗7克。
实施例4：一种酵素莱阳梨膏，包括12斤的莱阳梨与1份的中药汤剂低温发酵后低温负压蒸馏浓缩而成，所述的1份中药汤剂由如下重量份的药材熬制而成：甘草、干姜、大枣、荞麦、葛根、山楂、乌梅、藿香、砂仁、茯苓、枸杞子、菊花、罗汉果各9克，胖大海6克，白茅根、百合各4克，桔梗6克。
实施例5：一种酵素莱阳梨膏，包括8斤的莱阳梨与1份的中药汤剂低温发酵后低温负压蒸馏浓缩而成，所述的1份中药汤剂由如下重量份的药材熬制而成：甘草、干姜、大枣、荞麦、葛根、山楂、乌梅、藿香、砂仁、茯苓、枸杞子、菊花、罗汉果各11克，胖大海5克，白茅根、百合各4克，桔梗7克。
实施例6：实施例3的一种酵素莱阳梨膏的制备方法，其特征在于包含如下步骤：
A将莱阳梨洗净、称重、全梨隔水蒸透使梨子不氧化变质；
B将蒸透的全梨用机械或手工加压破碎成浆；
C中药汤剂的熬制：将甘草、干姜、大枣、荞麦、葛根、山楂、乌梅、藿香、砂仁、茯苓、枸杞子、菊花、罗汉果、胖大海、白茅根、百合、桔梗加入到2000-4000克水中，浸泡40至60分钟；
D将步骤B的梨浆和步骤C的药水混合物一同加热100摄氏度熬合30分钟；
E凉至40摄氏度时，滤去药渣，药液中加入红曲米充分搅拌形成酵液，比例为每一百斤药液加红曲米6斤；
F酵液密封发酵120天；
G以2000目筛网过滤去渣；
H加热至40摄氏度，负压蒸馏水份，糖度达80度时成膏出成品。
2006年至2016年共临床观察癌症患者人数500例，患者服用1–3个疗程便可
见效，有效率达90％以上。治愈率达百分45％以上
案例：
王XX，女，56岁，胃癌中期，莱阳市西关村。服用本品三个月肿瘤已经基本消失，身体恢复正常。
曲XX，女，45岁，莱阳市大夼村。乳癌早期，2008年一月患病，服用本品 两个月痊愈。
心脑血管临床1300多患者，有效率 99% ,治愈率达80%以上。
李X，男，38岁，莱阳市上夼村，高血压，90-150，服用三个月，血压正常。
王X，女，莱阳市西关村，50岁，脑血栓，上半身活动受限。服用六个月正常。
田X，莱阳市王格庄，男64岁，心慌心悸房颤，中风失语。腿脚受限服用一年正常。
Claims (5)
1.一种酵素莱阳梨膏，包括7—14斤的莱阳梨与1份的中药汤剂低温发酵后低温负压蒸馏浓缩而成，其特征在于：所述的1份中药汤剂由如下重量份的药材熬制而成：甘草、干姜、大枣、荞麦、葛根、山楂、乌梅、藿香、砂仁、茯苓、枸杞子、菊花、罗汉果各8-13克，胖大海4-8克，白茅根、百合各2-5克，桔梗5-9克。
2.根据权利要求1所述的一种酵素莱阳梨膏，其特征在于：所述的1份中药汤剂由如下重量份的药材熬制而成：甘草、干姜、大枣、荞麦、葛根、山楂、乌梅、藿香、砂仁、茯苓、枸杞子、菊花、罗汉果各10克，胖大海5克，白茅根、百合各3克，桔梗7克。
3.权利要求1或2所述的一种酵素莱阳梨膏的制备方法，其特征在于包含如下步骤：
A将莱阳梨洗净、称重、全梨隔水蒸透使梨子不氧化变质；
B将蒸透的全梨用机械或手工加压破碎成浆；
C中药汤剂的熬制：将甘草、干姜、大枣、荞麦、葛根、山楂、乌梅、藿香、砂仁、茯苓、枸杞子、菊花、罗汉果、胖大海、白茅根、百合、桔梗加入到2000-4000克水中，浸泡40至60分钟；
D将步骤B的梨浆和步骤C的药水混合物一同加热100摄氏度熬合30分钟；
E凉至40摄氏度时，滤去药渣，药液中加入红曲米充分搅拌形成酵液，比例为每一百斤药液加红曲米6斤；
F酵液密封发酵90-180天；
G以丝布或2000目筛网过滤去渣；
H加热至40摄氏度，负压蒸馏水份，糖度达80度时成膏出成品。
4.权利要求1或2所述的一种酵素莱阳梨膏在治疗心脑血管疾病中的应用。
5.权利要求1或2所述的一种酵素莱阳梨膏在预防癌症中的应用。
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106616710A (zh) * | 2016-12-28 | 2017-05-10 | 熙可食品(安徽)有限公司 | 一种沙棘秋梨膏的制备方法 |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1899504A (zh) * | 2006-06-29 | 2007-01-24 | 林良雅 | 一种雪梨膏及其制备方法 |
| CN102894425A (zh) * | 2011-07-27 | 2013-01-30 | 李守芹 | 秋梨膏醋饮料及其浓缩产品秋梨醋膏的加工工艺 |
| CN103461994A (zh) * | 2013-08-12 | 2013-12-25 | 杨如义 | 一种助消化的山楂瓜子汁 |
| CN105433185A (zh) * | 2015-11-27 | 2016-03-30 | 安徽菊泰滁菊草本科技有限公司 | 一种百合菊花梨润肺发酵饮料及其制备方法 |
| CN105558685A (zh) * | 2015-12-15 | 2016-05-11 | 麻城佳成生物科技有限公司 | 一种护眼红曲醋饮料及其制备方法 |
-
2016
- 2016-05-31 CN CN201610377349.6A patent/CN105995720A/zh active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1899504A (zh) * | 2006-06-29 | 2007-01-24 | 林良雅 | 一种雪梨膏及其制备方法 |
| CN102894425A (zh) * | 2011-07-27 | 2013-01-30 | 李守芹 | 秋梨膏醋饮料及其浓缩产品秋梨醋膏的加工工艺 |
| CN103461994A (zh) * | 2013-08-12 | 2013-12-25 | 杨如义 | 一种助消化的山楂瓜子汁 |
| CN105433185A (zh) * | 2015-11-27 | 2016-03-30 | 安徽菊泰滁菊草本科技有限公司 | 一种百合菊花梨润肺发酵饮料及其制备方法 |
| CN105558685A (zh) * | 2015-12-15 | 2016-05-11 | 麻城佳成生物科技有限公司 | 一种护眼红曲醋饮料及其制备方法 |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106616710A (zh) * | 2016-12-28 | 2017-05-10 | 熙可食品(安徽)有限公司 | 一种沙棘秋梨膏的制备方法 |
| CN106616698A (zh) * | 2016-12-28 | 2017-05-10 | 熙可食品(安徽)有限公司 | 一种桑葚秋梨膏的制备方法 |
| CN106666579A (zh) * | 2016-12-28 | 2017-05-17 | 熙可食品(安徽)有限公司 | 健脾润肺酸梨膏的制备方法 |
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| CN107006845A (zh) * | 2017-04-11 | 2017-08-04 | 宋厚澄 | 一种酵素梨膏及其生产方法 |
| CN107568724A (zh) * | 2017-11-01 | 2018-01-12 | 佛山市三水区敏俊食品有限公司 | 一种茬梨酵素 |
| CN108041375A (zh) * | 2017-11-23 | 2018-05-18 | 深圳市中科台富科技有限公司 | 一种发酵型梨汁饮料及其制备方法 |
| CN108850944A (zh) * | 2018-07-12 | 2018-11-23 | 河南省农业科学院园艺研究所 | 一种天然梨膏的加工方法 |
| CN110050917A (zh) * | 2018-09-25 | 2019-07-26 | 渤海大学 | 一种白茅根复合发酵型果蔬饮料的制备方法 |
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