CN105994341B - Anthranilamide compound and nicotine compound compounded pesticides - Google Patents

Anthranilamide compound and nicotine compound compounded pesticides Download PDF

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Publication number
CN105994341B
CN105994341B CN201610334513.5A CN201610334513A CN105994341B CN 105994341 B CN105994341 B CN 105994341B CN 201610334513 A CN201610334513 A CN 201610334513A CN 105994341 B CN105994341 B CN 105994341B
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Prior art keywords
compound
compounded pesticides
anthranilamide
nicotine
synergy
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CN105994341A (en
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孔繁蕾
吴桂秀
马英高
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JIANGSU AGRICULTURAL HORMONE ENGINEERING TECHNOLOGY RESEARCH CENTRE Co Ltd
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JIANGSU AGRICULTURAL HORMONE ENGINEERING TECHNOLOGY RESEARCH CENTRE Co Ltd
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N51/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds having the sequences of atoms O—N—S, X—O—S, N—N—S, O—N—N or O-halogen, regardless of the number of bonds each atom has and with no atom of these sequences forming part of a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides

Abstract

The invention discloses a kind of Anthranilamide compounds and nicotine compound compounded pesticides, its active component is made of Anthranilamide compound and nicotine compound according to 10: 1~1: 10 weight ratio, and the nicotine compound in compounded pesticides is preferably Diacloden, thiacloprid or dinotefuran.For compounded pesticides of the invention in crops such as rice, vegetables to pests significant effects such as prevention and treatment striped rice borer, planthopper, rice leaf roller, beet armyworm, prodenia lituras, synergistic effect is obvious, is suitble to industrial-scale production.The compounded pesticides of the invention dosage compared with single dose reduces, not only reduce production cost, and reduce residual quantity of the pesticide on crop, delay the generation of pest resistance to insecticide, and since the raising of control efficiency can reduce access times, to further reduce the cost, the influence to environment is reduced.

Description

Anthranilamide compound and nicotine compound compounded pesticides
Technical field
The present invention relates to a kind of compounded pesticides, and in particular to a kind of Anthranilamide compound and nicotinoids chemical combination Object compounded pesticides.
Background technique
Chinese patent literature CN103265527A disclose a kind of Anthranilamide compound and preparation method thereof and Using the chemical name of the Anthranilamide compound are as follows: the bromo- 1-(3- chloro-2-pyridyl of 3-)-N- [the thio formyl of 4- Amido -2- methyl -6-(methylamino formoxyl)-phenyl] -1H- pyrazoles -5- formamide, structural formula is as follows:
。
The document also discloses that the Anthranilamide compound can be with imidacloprid, thiacloprid, Diacloden or thiophene The anabasine insecticides such as worm amine prepare lethane.
But many experiments show that many lethanes show apparent antagonism, to be not suitable for industrialization Large-scale production.
Summary of the invention
The purpose of the present invention is to solve the above problem, provides a kind of with synergistic effect, suitable industrial-scale production Anthranilamide compound and nicotine compound compounded pesticides.
Realizing the technical solution of above-mentioned purpose of the present invention is: a kind of Anthranilamide compound and nicotine compound Compounded pesticides, active component by Anthranilamide compound and nicotine compound according to 10: 1~1: 10 weight Than composition.
The structural formula of above-mentioned Anthranilamide compound is as follows:
。
Above-mentioned compounded pesticides further include agriculturally acceptable solvent, auxiliary agent, synergist, bleeding agent, antifreeze, steady Determine agent, thickener etc..
Above-mentioned compounded pesticides can be prepared into any one dosage form used in suitable agricultural production by known method, than Comparatively ideal dosage form is suspending agent, water dispersion granule, aqueous emulsion, wettable powder, microemulsion and granule.
Above-mentioned compounded pesticides are prevented for preventing and treating agricultural pests, fruit tree and vegetable pest, gardening pest insect, forestry pest desinsection Method is controlled using spraying foliage spray, seed treatment, soil treatment or seed pelleting etc..
Above-mentioned compounded pesticides are for preventing and treating the lepidoptera pests such as mythimna separata, snout moth's larva, leafhopper, plant hopper and Diptera, half wing Mesh pest is preferred for preventing and treating the lepidoptera pests such as mythimna separata, snout moth's larva, leafhopper, plant hopper, is more preferably used for prevention and treatment snout moth's larva or flies Lice.
Nicotine compound in above-mentioned compounded pesticides is Diacloden, thiacloprid, clothianidin, dinotefuran or pyrrole worm Quinoline, preferably Diacloden, thiacloprid or dinotefuran, more preferably Diacloden.
When the nicotine compound in above-mentioned compounded pesticides is dinotefuran, Anthranilamide compound and furan worm The weight ratio of amine is preferably 3: 1~1: 3, preferably 3: 1,1: 1 or 1: 2, more preferably 1: 1.
When the nicotine compound in above-mentioned compounded pesticides is thiacloprid, Anthranilamide compound and thiophene worm The weight ratio of quinoline is preferably 1: 1~1: 2, and more preferably 1: 2.
When the nicotine compound in above-mentioned compounded pesticides is Diacloden, Anthranilamide compound and thiophene worm The weight ratio of piperazine is preferably 1: 1~1: 3, and more preferably 1: 2~1: 2.5.
The good effect that the present invention has: (1) proving by biological activity determination, and compounded pesticides of the invention are in water The crops such as rice, vegetables to prevention and treatment striped rice borer, planthopper, rice leaf roller, beet armyworm, the pests significant effect such as prodenia litura, Synergistic effect is obvious, is suitble to industrial-scale production.(2) the compounded pesticides of the invention dosage compared with single dose reduces, no It reduced by only production cost, and reduce residual quantity of the pesticide on crop, delay the generation of pest resistance to insecticide, and due to anti- The raising for controlling effect can reduce access times, to further reduce the cost, reduce the influence to environment.(3) with the present invention Anthranilamide compound and Thiamethoxam compound insecticide to striped rice borer, planthopper prevention and treatment for, when weight ratio be 1: 2 When~1: 2.5, for 10 grams of dosage per acre, single dose Anthranilamide compound needs 10 yuan/mu, and compounded pesticides are only 4 yuan/mu are needed, cost reduces 60%.
Specific embodiment
To better understand the essence of the present invention, in conjunction with indoor biological activity and the independent measurement of joint in of the invention Hold and further illustrate, but must not believe that limitation of the present invention.
(test example 1)
This test example is Anthranilamide compound (being indicated below with JES-127) and Thiamethoxam compound insecticide Prevent and treat co-toxicity test in rice-stem borer room.
Test worm: striped rice borer, 3 enable nymph, raise in laboratory.
Reagent agent: 90%JES-127, Jiangsu Agricultural Hormone Engineering Technology Research Centre Co., Ltd. provide；96% thiophene Worm piperazine, Jiangsu Province south pesticide research center provide.
25 ± 1 DEG C of room temperature of test.
Using leaching rice seedling feeding method: every group of rice seedling being soaked 15s in medical fluid, access striped rice borer, 3 enable nymph cultivate, 7 after medicine Its investigation number of dead and live insects, evaluates synergy type using co-toxicity coefficient method.
It is for statistical analysis with DPS statistical analysis software, calculate the LC of each medicament50, and mixture is calculated according to Sun Yunpei's Method Co-toxicity coefficient (CTC value).
Survey toxicity index (ATI)=(standard agent LC50/ reagent agent LC50) × 100.
The percentage composition of (I)+(II) medicament virulence refers in theoretical toxicity index (TTI)=(I) medicament toxicity index × mixture The percentage composition of (II) in number × mixture.
Co-toxicity coefficient (CTC)=mixture surveys toxicity index (ATI)/mixtures theoretical toxicity index (TTI) × 100.
Act on the criteria for classifying according to NY/T11547.7-2006 insecticide combination: co-toxicity coefficient (CTC) >=120 shows as increasing Effect effect；Co-toxicity coefficient (CTC)≤80 shows as antagonism；80 < co-toxicity coefficient (CTC) < 120 show as summation action.
JES-127 and Thiamethoxam compound insecticide the results are shown in Table 1 to rice-stem borer toxicity test.
Table 1
LC50(mg/L) ATI TTI CTC Synergy type
JES-127 4.0924 100 - - -
Diacloden 84.6942 4.8 - - -
1∶1 4.5134 90.67 52.415 172.9 Synergy
1∶1.5 4.5602 89.17 42.90 209.2 Synergy
1∶2 2.3161 176.69 36.55 483.39 Synergy
1∶2.5 1.7573 232.88 32.02 727.26 Synergy
1∶3 4.4461 92.04 28.62 321.58 Synergy
As can be seen from Table 1: when JES-127 is compounded according to above-mentioned weight ratio with Diacloden, all having synergistic effect, especially When weight ratio is 1: 2~1: 2.5, synergistic effect is significant.
(test example 2)
Co-toxicity of the JES-127 with thiacloprid compounded pesticides to rice-stem borer is tested according to the method for test example 1, It the results are shown in Table 2.
95% thiacloprid of reagent agent is provided by Jiangsu Province south pesticide research center.
Table 2
LC50(mg/L) ATI TTI CTC Synergy type
JES-127 4.0924 100 - - -
Thiacloprid 43.55 9.4 - - -
1∶1 6.3484 64.46 54.70 92.98 It is added
1∶1.5 5.3576 76.38 45.60 101.01 It is added
1∶2 8.0100 51.09 39.60 145.08 Synergy
1∶2.5 7.8530 52.11 35.09 77.74 Antagonism
1∶3 7.4323 55.06 32.05 33.23 Antagonism
As can be seen from Table 2: when JES-127 is compounded with thiacloprid according to weight ratio 1: 2, there is notable synergistic effect.
(test example 3)
Co-toxicity of the JES-127 with dinotefuran compounded pesticides to rice-stem borer is tested according to the method for test example 1, It the results are shown in Table 3.
Table 3
LC50(mg/L) ATI TTI CTC Synergy type
JES-127 4.0924 100 - - -
Dinotefuran 56.0672 7.3 - - -
3∶1 3.5386 115.63 76.825 150.54 Synergy
2∶1 5.4251 75.43 69.10 109.17 It is added
1∶1 4.1048 99.70 53.65 185.83 Synergy
1∶2 6.5671 62.30 38.20 163.13 Synergy
1∶3 15.015 27.26 30.475 89.44 It is added
As can be seen from Table 3: when JES-127 is compounded with dinotefuran according to weight ratio 1: 1, co-toxicity coefficient highest, synergy is made With most by force.
Prevention and treatment for striped rice borer, from the point of view of the test result of 1~table of table 3, JES-127 and Thiamethoxam compound insecticide increase Effect effect is substantially better than JES-127 and thiacloprid compounded pesticides and JES-127 and dinotefuran compounded pesticides, and thiophene worm Piperazine raw medicine price is minimum, and cost is lower.
(test example 4)
This test example is co-toxicity test in JES-127 and Thiamethoxam compound insecticide control brown paddy plant hopper room.
Test worm: brown paddy plant hopper, 3 enable nymph, raise in laboratory.
Reagent agent is identical as test example 1.
25 ± 1 DEG C of room temperature of test.
Using leaching rice seedling feeding method: every group of rice seedling being soaked 15s in medical fluid, access brown paddy plant hopper, 3 enable nymph cultivate, 3 after medicine It, 7 days investigation number of dead and live insects, using co-toxicity coefficient method evaluate synergy type.
It is for statistical analysis with DPS statistical analysis software, calculate the LC of each medicament50And LC90, and according to Sun Yunpei's Method meter Calculate the co-toxicity coefficient (CTC value) of mixture.
3 days after medicine, 7 days toxicity test results be shown in Table 4 and table 5 respectively.
Table 4
LC50(mg/L) LC90(mg/L) CTC Synergy type
JES-127 39.1144 184.0677 - -
Diacloden 11.06669 96.202 - -
1∶0.25 18.4929 60.8526 140.36 Synergy
1∶0.5 24.6378 161.3432 86.06 It is added
1∶1 17.7792 153.0053 97.04 It is added
1∶1.5 17.5632 66.0883 88.35 It is added
1∶2 5.341 21.6215 272.29 Synergy
1∶2.5 5.1151 30.3218 272.11 Synergy
1∶3 4.6411 14.4772 290.54 Synergy
Table 5
LC50(mg/L) LC90(mg/L) CTC Synergy type
JES-127 21.0541 55.8847 - -
Diacloden 1.4639 3.9848 - -
1∶0.25 9.7856 26.6177 58.52 Antagonism
1∶0.5 3.7156 9.1853 103.77 It is added
1∶1 2.7634 6.814 99.06 It is added
1∶1.5 1.5956 4.955 146.14 Synergy
1∶2 1.3792 3.5869 153.86 Synergy
1∶2.5 0.9807 1.63 203.32 Synergy
1∶3 1.8555 3.647 102.81 It is added
By table 4 and table 5 it can be seen that JES-127 is compounded with Thiamethoxam compound insecticide according to weight ratio 1: 2~1: 2.5 When, show stable synergistic effect.
(test example 5)
According to the method test JES-127 and thiacloprid compounded pesticides of test example 4 to the co-toxicity of brown paddy plant hopper, after medicine 6 days toxicity tests the results are shown in Table 6.
Table 6
LC50(mg/L) LC90(mg/L) CTC Synergy type
JES-127 11.8870 56.7790 - -
Thiacloprid 4.0533 25.9190 - -
1∶0.5 11.2522 27.8234 64.25 Antagonism
1∶1 6.5018 30.5134 92.98 It is added
1∶1.5 5.4491 25.6060 101.01 It is added
1∶2 3.5803 30.1393 145.08 Synergy
1∶2.5 6.4230 156.7446 77.74 Antagonism
1∶3 14.6028 91.0318 33.23 Antagonism
1∶4 16.1685 107.8468 28.87 Antagonism
As can be seen from Table 6: when JES-127 is compounded with thiacloprid according to weight ratio 1: 2, there is notable synergistic effect.
Prevention and treatment for brown paddy plant hopper, from the point of view of the test result of 4~table of table 6, JES-127 and Thiamethoxam compound insecticide are still So better than JES-127 and thiacloprid compounded pesticides.

Claims (1)

1. a kind of Anthranilamide compound and nicotine compound compounded pesticides, it is characterised in that: its active component It is made of Anthranilamide compound and dinotefuran according to 3: 1,1: 1 or 1: 2 weight ratio；
Or it is made of Anthranilamide compound and thiacloprid according to 1: 2 weight ratio；
Or it is made of Anthranilamide compound and Diacloden according to 1: 2~1: 2.5 weight ratio；
The structural formula of the Anthranilamide compound is as follows:
。
CN201610334513.5A 2016-05-19 2016-05-19 Anthranilamide compound and nicotine compound compounded pesticides Active CN105994341B (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103265527A (en) * 2013-06-07 2013-08-28 江苏省农用激素工程技术研究中心有限公司 Anthranilamide compound as well as preparation method and application thereof
CN103923123A (en) * 2014-05-04 2014-07-16 中国农业科学院植物保护研究所 N-alkylation phthalimide piperazine derivatives as well as preparation method and application thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103265527A (en) * 2013-06-07 2013-08-28 江苏省农用激素工程技术研究中心有限公司 Anthranilamide compound as well as preparation method and application thereof
CN103923123A (en) * 2014-05-04 2014-07-16 中国农业科学院植物保护研究所 N-alkylation phthalimide piperazine derivatives as well as preparation method and application thereof

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