CN105963163B - A kind of dewrinkling spot-eliminating Essence and preparation method thereof - Google Patents
A kind of dewrinkling spot-eliminating Essence and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A—HUMAN NECESSITIES
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- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The present invention relates to technical field of skin care, more particularly to a kind of dewrinkling spot-eliminating Essence and preparation method thereof, dewrinkling spot-eliminating Essence, by weight, including following components: 2-5 parts of xanthan gum, 3-8 parts of glycerol, 40-65 parts of water, 1-2.5 parts of cetostearyl alcohol, 0.5-3 parts of stearine, 1-2 parts of caprylic/capric triglyceride, 2-6 parts of ethylhexyl palmitate, 2-8 parts of isononyl isononanoate, 1-5 parts of shea butter, 0.1-0.5 parts of preservative, 0.008-3 parts of the mescenchymal stem cell factor, 0.001-0.05 parts of small active peptides, 0.001-1 parts of carnosine, dewrinkling spot-eliminating Essence can effective activation skin cell, improve skin reconstruction ability, repair and supplement damaged cell tissue, slow down the generation of wrinkle, with dispel depth The pigment of color keeps skin bright thoroughly clear, and preparation method is simple, easy to operate, easy to spread.
Description
Technical field
The present invention relates to technical field of skin care, and in particular to a kind of dewrinkling spot-eliminating Essence and preparation method thereof.
Background technique
With the improvement of the quality of life, people pursue beauty desire increasingly increase, anti-aging wrinkle reduction, return to the youth at
The hot topic of the vast women that likes to be beautiful.
The reason of generating wrinkle mainly has four aspects: natural aging, centrifugal force, light aging and light injury, facial expression
The excessive contraction of flesh.Wherein the most key factor is two kinds of forms of natural aging and light aging, the former referred mainly to the age
Growth, existing irresistible factor in body, the aging as caused by heredity, gravity, endocrine and immune function etc.；Afterwards
Person has aggravated the process of naturally-aged mainly due to the effect of ultraviolet light.Increasingly there is loose, thinning, water content decline in skin,
Seem drying, there is the scales of skin that peel off, tarnishes；Elasticity and consolidation also decline therewith；Wrinkle is formed, and is gradually increased, and is deepened.This
Outside, the sensibility of skin increases, and pigmentation is deepened.The inherence of skin aging shows as the decline of skin cell proliferation ability, table
Skin renewal speed slows down, skin reconstruction reduced capability, and skin collagen synthesis slows down, the decline of cutaneous immunisation power, and Magnifying chromoscopy is uneven
It is even etc..
Human body is in the atomization of cell, and a part of cell height differentiation loses the ability divided again completely, simultaneously
A part of undifferentiated initial cell is remained, this part cell is exactly a kind of to have the dry thin of self-renewing and differentiation potential
Born of the same parents.Stem cell can be continuously updated duplication, be divided into the cell with various functions, to repair or supplement impaired groups of cells
It knits, or even replaces dead cell, promote the formation of human stem cell, to alleviate human senility.Stem cell possesses high doctor
Value and cosmetic values are learned, medical field is known as " general-purpose cell ".Some stem cells are dissolved into skin care item, so as to stimulating skin
The power of regeneration of skin stem cell can accelerate self more raw and reparation of skin.
Mescenchymal stem cell (Mesenchymal Stem Cells, MSCs) is the important member of stem cell line,
From the mesoderm and ectoderm of mesoderm growing early stage.Mescenchymal stem cell is initially found in marrow, because it is with Multidirectional Differentiation
Potential, hematopoiesis support and promote stem cell implantation, immunoregulation and the concern that people are increasingly subject to the features such as self-replacation.
Mescenchymal stem cell is in vivo or in vitro under specific inductive condition, can be divided into fat, bone, cartilage, muscle, tendon, ligament,
The Various Tissues cell such as nerve, liver, cardiac muscle, endothelium still has multi-lineage potential after continuous passage culture and freezen protective, can
As ideal seed cell for injuries of tissues and organs reparation caused by aging and lesion.
Summary of the invention
The purpose of the present invention is aiming at the shortcomings in the prior art, provide a kind of dewrinkling spot-eliminating Essence and its preparation side
Method, dewrinkling spot-eliminating Essence of the invention can effective activation skin cell, improve skin reconstruction ability, repair and supplement is impaired thin
Born of the same parents' tissue, slows down the generation of wrinkle, and dispels dark pigment, keeps skin bright thoroughly clear, and preparation method is simple, easy to operate,
It is easy to spread.
The purpose of the present invention is achieved through the following technical solutions:
A kind of dewrinkling spot-eliminating Essence, by weight, including following components:
Component A: 2-5 parts of xanthan gum, 3-8 parts of glycerol, 40-65 parts of water.
B component: 1-2.5 parts of cetostearyl alcohol, 0.5-3 parts of stearine, caprylic/capric triglyceride 1-2
Part, 2-6 parts of ethylhexyl palmitate, 2-8 parts of isononyl isononanoate.
Component C: 1-5 parts of shea butter, 0.1-0.5 parts of preservative.
D component: 0.008-3 parts of the mescenchymal stem cell factor, 0.001-0.05 parts of small active peptides, carnosine
0.001-1 parts.
Preferably, the mescenchymal stem cell factor, small active peptides, the weight ratio of carnosine are (60 ~ 1): 1:(10 ~
1).Small active peptides are a kind of biochemical substances between amino acid and protein, are the segment of a protein, structure
Simply, molecular weight is small, unsaturated, can be directly entered into the cell by the infiltration of cell membrane with original shape, without disappearing again
Change, also do not need to expend energy, therefore absorption, conversion and the utilization of small active peptides, be all it is efficient, complete, thorough, directly
The metabolism for connecing intervention muscle cell, endocrine cell, Skin Cell, participate in the growth of cell, development, physiological function and
Division growth links；Carnosine (L-Carnosine), scientific name β-alanyl-L-histidin, carnosine have very strong anti-oxidant
Ability can remove the fatty acid excessive oxidation for making cell membrane during oxidative stress and the active oxygen radical (ROS) formed
And alpha-beta unsaturated aldehyde；(60 ~ 1): 1:(10 ~ 1) the mescenchymal stem cell factor under ratio, small active peptides and carnosine tool
Play the role of cooperateing with and mutually promoting well, plays the mescenchymal stem cell factor, small active peptides and carnosine effectively
Respective effect, skin cell activate comprehensively, obtain efficient repair.
Preferably, the mescenchymal stem cell factor is the fat mesenchymal stem cell factor, the fat mesenchymal stem cell factor
From human body itself, skin cell is easy to absorb matrix.
Preferably, small active peptides are the high activity peptide by 2~4 Amino acid profiles, and structure is simple, molecular weight
It is small, it is easier to penetrate into skin cell, increases the validity of this Essence.
Preferably, preservative 1,2- pentanediol and 1, at least one of 2- hexylene glycol.
The effect of each component is as follows:
Glycerol has water imbibition, and thin film can be formed on the skin by putting on the skin, the work for having isolation air and preventing moisture from evaporating
With, moreover it is possible to the moisture in air is absorbed, it can make skin keep soft, and high resilience is not damaged by dust, weather etc. and done
It is dry, play the role of preventing skin frostbite, moisturizer and softening agent are played in Essence.
Xanthan gum can provide excellent stability to Essence, and high viscosity when standing is conducive in personal care product
The stabilization of evenly dispersed oil phase, the shear shinning property for wiping the used time then provide good lubrication and skin toner effect.
Cetostearyl alcohol is a kind of substance of White waxy, can provide creamy texture, and can help will be in skin care item
Various composition mix, form stable mixture.
Stearine hydrolysis is good, has very strong emulsifiability, has special stability, thermal stability and drop
Viscosity is very strong, and the HLB value of polyglycerol ester is extensive, can reduce the surface tension of water, forms micella, has decontamination, emulsification, divides
It dissipates, washing, wet, infiltration, diffusion, blistering, antioxygen, more function such as viscosity-adjusting agent, sterilize, prevent aging, is antistatic, preventing partial crystallization
Can, itself is safe and nontoxic, nontoxic to the human body.
Caprylic/capric triglyceride is easy to be absorbed by the skin, play the role of to the uniform and smooth of Essence it is good,
Keep skin lubrication glossy, can be used as the base-material of moisturizing factor, for the stabilizer as Essence, antifreezing agent, homogeneous agent.
Ethylhexyl palmitate is a kind of yellowish oily liquids, not oxidizable, and non-discolouring, stability is good, is had good
Moisturizing, extension and permeability, moisten and softening skin and without greasy feeling be good emollient.
Isononyl isononanoate has unique more methyl branch structures, and dry and comfortable and soft feel is splendid emollient,
It is good to silicone oil intermiscibility, it can solve the problems, such as that silicone oil low temperature is precipitated, be the stabilizer and coupling agent of silicone oil, have very well to colorant
Dispersibility, viscosity is low, and skin sense is salubrious, no greasy feeling.
Shea butter has stronger water lock ability, has good affinity to skin, except as excellent moisturizer and
Outside conditioner or it is a kind of have effects that helping for curing protrusion, the vitamin A in shea butter to many skin defects as wrinkle
Folding, eczema etc. dispel important improvement effect；Shea butter to treating skin allergy, chapped skin, skin ulcer,
All kinds of scytitis, insect bite and skin burn etc. also have improvement result, it can greatly reduce scar area, can treat rheumatism
Disease and myalgia, for having the function of skin care and making skin rehabilitation in cosmetics.
A kind of preparation method of dewrinkling spot-eliminating Essence, comprising the following steps:
A) each component is weighed by above-mentioned formula；
B) component A is put into vacuum emulsification pot, is heated with stirring to 75~85 DEG C, then proceedes to 3~9 points of stirring
Clock keeps the temperature 15~25 minutes, melts component sufficiently, is uniformly mixed, after be cooled to 40~50 DEG C, for B component is added, and melt
Melt B component to prepare；
C) it is added B component while stirring, vacuum homogeneous 5~10 minutes；
D) C component is added, is stirred under vacuum uniform；
E) be added D component, the later period be added D component, can avoid early period process time it is too long and make mescenchymal stem cell because
Son, small active peptides and carnosine failure, are stirred under vacuum uniformly, are cooled to 25-35 DEG C, discharging.
Beneficial effects of the present invention: A, B, after component C softening and soft and moist skin, by moisture content, nutrition and the locking of D component
In skin surface, then small active peptides directly penetrate into skin cell, participate in the metabolism of cell, and promote mesenchyma dry
The infiltration of cell factor, is repaired and supplement damaged cell tissue, improvement skin reconstruction ability slow down the generation of wrinkle, and dispel
Dark pigment, the active oxygen that carnosine is removed the fatty acid excessive oxidation for making cell membrane during oxidative stress and formed are free
Base (ROS) and alpha-beta unsaturated aldehyde, keep skin new life vibrant, and the colour of skin is bright thoroughly clear；Preparation method of the invention is protected well
The effective ingredient of Essence of the present invention is stayed, and step is simple, it is easily operated, it is easy to spread.
Specific embodiment
The invention will be further described with the following Examples.
Embodiment 1
In the present embodiment, a kind of dewrinkling spot-eliminating Essence, by weight, including following components:
Component A: 2 parts of xanthan gum, 3 parts of glycerol, 40 parts of water.
B component: 1 part of cetostearyl alcohol, 0.5 part of stearine, 1 part of caprylic/capric triglyceride, palmitinic acid
2 parts of ethylhexyl, 2 parts of isononyl isononanoate.
Component C: 1 part of shea butter, 1,2- 0.1 part of pentanediol.
D component: 0.008 part of the fat mesenchymal stem cell factor, 0.001 part of small active peptides, 0.001 part of carnosine.
Preferably, small active peptides are the high activity peptide by 2 and 3 Amino acid profiles.
The preparation method of above-mentioned Essence, comprising the following steps:
A) each component is weighed by above-mentioned formula；
B) component A is put into vacuum emulsification pot, is heated with stirring to 75 DEG C, then proceed to stirring 3 minutes, heat preservation 15
Minute, melt component sufficiently, be uniformly mixed, after be cooled to 40 DEG C, for B component is added, and melts B component and prepare；
C) it is added B component while stirring, vacuum homogeneous 5 minutes；
D) C component is added, is stirred under vacuum uniform；
E) D component is added, is stirred under vacuum uniformly, is cooled to 25 DEG C, discharging.
Embodiment 2
In the present embodiment, a kind of dewrinkling spot-eliminating Essence, by weight, including following components:
Component A: 3 parts of xanthan gum, 4 parts of glycerol, 50 parts of water.
B component: 1.5 parts of cetostearyl alcohol, 1 part of stearine, 1.2 parts of caprylic/capric triglyceride, palmitinic acid
3 parts of ethylhexyl, 3 parts of isononyl isononanoate.
Component C: 2 parts of shea butter, 1,2- 0.1 part of pentanediol, 1,2- 0.1 part of hexylene glycol.
D component: 0.5 part of the fat mesenchymal stem cell factor, 0.005 part of small active peptides, it is preferable that small molecule is living
Property peptide be by 2~4 Amino acid profiles high activity peptide, 0.005 part of carnosine.
The preparation method of above-mentioned Essence, comprising the following steps:
A) each component is weighed by above-mentioned formula；
B) component A is put into vacuum emulsification pot, is heated with stirring to 80 DEG C, then proceed to stirring 4 minutes, keep the temperature 20 points
Clock melts component sufficiently, is uniformly mixed, after be cooled to 45 DEG C, for B component is added, and melts B component and prepare；
C) it is added B component while stirring, vacuum homogeneous 6 minutes；
D) C component is added, is stirred under vacuum uniform；
E) be added D component, the later period be added D component, can avoid early period process time it is too long and make mescenchymal stem cell because
Son, small active peptides and carnosine failure, are stirred under vacuum uniformly, are cooled to 28 DEG C, discharging.
Embodiment 3
In the present embodiment, a kind of dewrinkling spot-eliminating Essence, by weight, including following components:
Component A: 4 parts of xanthan gum, 5 parts of glycerol, 55 parts of water.
B component: 2 parts of cetostearyl alcohol, 1.5 parts of stearine, 1.4 parts of caprylic/capric triglyceride, palmitinic acid
4 parts of ethylhexyl, 5 parts of isononyl isononanoate.
Component C: 3 parts of shea butter, 1,2- 0.25 part of hexylene glycol.
D component: 1 part of the fat mesenchymal stem cell factor, 0.03 part of small active peptides, 0.5 part of carnosine.
Preferably, small active peptides are the high activity peptide by 2~4 Amino acid profiles.
The preparation method of above-mentioned Essence, comprising the following steps:
A) each component is weighed by above-mentioned formula；
B) component A is put into vacuum emulsification pot, is heated with stirring to 80 DEG C, then proceed to stirring 6 minutes, keep the temperature 20 points
Clock melts component sufficiently, is uniformly mixed, after be cooled to 45 DEG C, for B component is added, and melts B component and prepare；
C) it is added B component while stirring, vacuum homogeneous 7 minutes；
D) C component is added, is stirred under vacuum uniform；
E) be added D component, the later period be added D component, can avoid early period process time it is too long and make mescenchymal stem cell because
Son, small active peptides and carnosine failure, are stirred under vacuum uniformly, are cooled to 30 DEG C, discharging.
Embodiment 4
In the present embodiment, a kind of dewrinkling spot-eliminating Essence, by weight, including following components:
Component A: 4.5 parts of xanthan gum, 7 parts of glycerol, 60 parts of water.
B component: 2.2 parts of cetostearyl alcohol, 2.5 parts of stearine, 1.8 parts of caprylic/capric triglyceride, palm
5 parts of sour ethylhexyl, 7 parts of isononyl isononanoate.
Component C: 4 parts of shea butter, 1,2- 0.1 part of pentanediol, 1,2- 0.3 part of hexylene glycol.
D component: 2 parts of the fat mesenchymal stem cell factor, 0.05 part of small active peptides, it is preferable that small active peptides
For by the high activity peptide of 2~4 Amino acid profiles, 0.8 part of carnosine.
The preparation method of above-mentioned Essence, comprising the following steps:
A) each component is weighed by above-mentioned formula；
B) component A is put into vacuum emulsification pot, is heated with stirring to 80 DEG C, then proceed to stirring 8 minutes, heat preservation 22
Minute, melt component sufficiently, be uniformly mixed, after be cooled to 46 DEG C, for B component is added, and melts B component and prepare；
C) it is added B component while stirring, vacuum homogeneous 8 minutes；
D) C component is added, is stirred under vacuum uniform；
E) be added D component, the later period be added D component, can avoid early period process time it is too long and make mescenchymal stem cell because
Son, small active peptides and carnosine failure, are stirred under vacuum uniformly, are cooled to 30 DEG C, discharging.
Embodiment 5
In the present embodiment, a kind of dewrinkling spot-eliminating Essence, by weight, including following components:
Component A: 5 parts of xanthan gum, 8 parts of glycerol, 65 parts of water.
B component: 2.5 parts of cetostearyl alcohol, 3 parts of stearine, 2 parts of caprylic/capric triglyceride, palmitinic acid second
6 parts, 8 parts of isononyl isononanoate of the own ester of base.
Component C: 5 parts of shea butter, 1,2- 0.3 part of pentanediol, 1,2- 0.2 part of hexylene glycol.
D component: 3 parts of the fat mesenchymal stem cell factor, 0.05 part of small active peptides, it is preferable that small active peptides
For by the high activity peptide of 2~4 Amino acid profiles, 1 part of carnosine.
The preparation method of above-mentioned Essence, comprising the following steps:
A) each component is weighed by above-mentioned formula；
B) component A is put into vacuum emulsification pot, is heated with stirring to 85 DEG C, then proceed to stirring 9 minutes, keep the temperature 25 points
Clock melts component sufficiently, is uniformly mixed, after be cooled to 50 DEG C, for B component is added, and melts B component and prepare；
C) it is added B component while stirring, vacuum homogeneous 10 minutes；
D) C component is added, is stirred under vacuum uniform；
E) be added D component, the later period be added D component, can avoid early period process time it is too long and make mescenchymal stem cell because
Son, small active peptides and carnosine failure, are stirred under vacuum uniformly, are cooled to 35 DEG C, discharging.
Dewrinkling spot-eliminating effect experiment
The dewrinkling spot-eliminating effect that the made Essence of above-described embodiment is evaluated by experiment on probation, chooses 150 35-55
Year, the healthy population of men and women came using they being arbitrarily divided into 5 groups, every group of 30 people, experimental group 1 is to use embodiment 1
Product, experimental group 2 use 2 product of embodiment, and experimental group 3 uses 3 product of embodiment, and experimental group 4 uses 4 product of embodiment,
Experimental group 5 uses 5 product of embodiment, sooner or later each daily to apply face with Essence of the present invention twice, is used continuously one month, uses
Situation is as shown in the table.
In conclusion dewrinkling spot-eliminating Essence effective percentage of the present invention is up to 93%, and after using the present invention, the effect of dewrinkling spot-eliminating
Fruit will increase and more obvious at any time.
The dewrinkling spot-eliminating effect of dewrinkling spot-eliminating Essence of the invention is obvious, is readily produced, and has good dissemination.
Finally it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention, rather than the present invention is protected
The limitation of range is protected, although explaining in detail referring to preferred embodiment to the present invention, those skilled in the art are answered
Work as understanding, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the reality of technical solution of the present invention
Matter and range.
Claims (2)
1. a kind of dewrinkling spot-eliminating Essence, it is characterised in that: by weight, including following components:
Component A: 2-5 parts of xanthan gum, 3-8 parts of glycerol, 40-65 parts of water；
B component: 1-2.5 parts of cetostearyl alcohol, 0.5-3 parts of stearine, 1-2 parts of caprylic/capric triglyceride, palm fibre
2-6 parts of palmitic acid acid ethylhexyl, 2-8 parts of isononyl isononanoate；
Component C: 1-5 parts of shea butter, 0.1-0.5 parts of preservative；
D component: 0.008-3 parts of the mescenchymal stem cell factor, 0.001-0.05 parts of small active peptides, carnosine 0.001-1
Part；
The mescenchymal stem cell factor, small active peptides, the weight ratio of carnosine are (60 ~ 1): 1:(10 ~ 1)；It is described
The mescenchymal stem cell factor is the fat mesenchymal stem cell factor；The small active peptides are by 2~4 Amino acid profiles
High activity peptide；The preservative is 1,2- pentanediol and 1, at least one of 2- hexylene glycol.
2. a kind of preparation method of dewrinkling spot-eliminating Essence, it is characterised in that: the following steps are included:
A) formula according to claim 1 weighs each component；
B) component A is put into vacuum emulsification pot, is heated with stirring to 75~85 DEG C, then proceedes to stirring 3~9 minutes, protected
Temperature was cooled to 40~50 DEG C after 15~25 minutes；
C) it is added B component while stirring, vacuum homogeneous 5~10 minutes；
D) C component is added, is stirred under vacuum uniform；
E) D component is added, is stirred under vacuum uniformly, is cooled to 25-35 DEG C, discharging.
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| CN106344493A (en) * | 2016-10-12 | 2017-01-25 | 领航干细胞再生医学工程有限公司 | Preparation method of essence containing human mesenchymal stem cell factors |
| CN109394639A (en) * | 2018-11-12 | 2019-03-01 | 广东科玮生物技术股份有限公司 | A kind of anti-ageing activating essence and preparation method thereof containing ferment |
| CN111956585B (en) * | 2020-08-10 | 2021-04-30 | 湖南本美生物科技有限公司 | Carnosine freckle removing liquid and preparation method thereof |
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| CN102670438A (en) * | 2012-04-25 | 2012-09-19 | 珠海市时代经典化妆品有限公司 | Anti-ageing skincare product and preparation method thereof |
| CN103735470A (en) * | 2014-01-23 | 2014-04-23 | 广州丹奇日用化工厂有限公司 | Two-phase cosmetic containing apple stem cell extract and preparation method thereof |
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