CN105963163A - Wrinkle-resisting and freckle-removing essence and preparation method thereof - Google Patents
Wrinkle-resisting and freckle-removing essence and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention relates to the technical field of skin care products, in particular to wrinkle-resisting and freckle-removing essence and a preparation method thereof. The wrinkle-resisting and freckle-removing essence is prepared from the following components in parts by weight: 2 to 5 parts of xanthan gum, 3 to 8 parts of glycerinum, 40 to 65 parts of water, 1 to 2.5 parts of cetearyl alcohol, 0.5 to 3 parts of glyceryl stearate, 1 to 2 parts of caprylic/capric triglyceride, 2 to 6 parts of ethylhexyl palmitate, 2 to 8 parts of isononyl isononanoate, 1 to 5 parts of oleum butyrospermi parkii, 0.1 to 0.5 part of preservative, 0.008 to 3 parts of mesenchymal stem cell factor, 0.001 to 0.05 part of small molecular active peptide and 0.001 to 1 part of carnosine. The wrinkle-resisting and freckle-removing essence disclosed by the invention is capable of effectively activating skin cells, improving skin reconstruction ability, repairing and supplementing injured cell tissues, relieving generation of wrinkles, removing dark pigment and enabling the skin to be bright and clear; the preparation method is simple, operation is easy, and popularization is easy.
Description
Technical field
The present invention relates to technical field of skin care, be specifically related to a kind of dewrinkling spot-eliminating essence and preparation method thereof.
Background technology
Along with the raising of quality of life, people pursue the desire of U.S. to be increased day by day, anti-aging wrinkle reduction, returns to the youth and has become the hot topic of the vast women that likes to be beautiful.
The reason producing wrinkle mainly has four aspects: the contraction that natural aging, centrifugal force, photoaging and photic damage, facial expression muscle are too much.The most the most key factor is natural aging and two kinds of forms of photoaging, and the former refers mainly to advancing age, the irresistible factor existed in body, as heredity, gravity, endocrine and immunologic function etc. cause aging；The latter, mainly due to the effect of ultraviolet, has increased the weight of the process of naturally-aged.Relaxing day by day occurs in skin, thinning, water content declines, it appears is dried, has squama, tarnish；Elastic and consolidation declines the most therewith；Wrinkle is formed, and gradually increases, and deepens.Additionally, the sensitivity of skin increases, pigmentation is deepened.The inherence of skin aging shows as skin cell proliferation ability and declines, and epidermal renewal speed slows down, skin reconstruction reduced capability, and skin collagen synthesis is slowed down, and skin immunization power declines, and Magnifying chromoscopy is uneven.
Human body is in the atomization of cell, and the differentiation of a part of cell height loses the ability divided again completely, remains a part of undifferentiated germinal cell simultaneously, and this part cell is exactly the stem cell that a class has self renewal and differentiation potential.Stem cell can be continuously updated duplication, is divided into the cell with various function, to repair or to supplement impaired cell tissue, even replaces dead cell, promotes the formation of human stem cell, thus alleviate human senility.Stem cell has high medical value and its cosmetic values, and medical circle is referred to as " general-purpose cell ".Some stem cell are dissolved in the middle of skin care item, so as to stimulate skin progenitor cell regeneration capacity, can accelerate skin oneself more raw and repair.
Mescenchymal stem cell (Mesenchymal Stem Cells, MSCs) is the important member of stem cell line, derives from and grows mesoderm in early days and ectoderm.Mescenchymal stem cell initially finds in bone marrow, has the features such as multi-lineage potential, hematopoiesis support and the implantation of promotion stem cell, immunoregulation and self replication because of it and is increasingly subject to the concern of people.Mescenchymal stem cell is in vivo or under external specific inductive condition, the Various Tissues cells such as fat, bone, cartilage, muscle, tendon, ligament, nerve, liver, cardiac muscle, endothelium can be divided into, still there is multi-lineage potential, the injuries of tissues and organs reparation that can cause for old and feeble and pathological changes as preferable seed cell after continuous passage cultivation and freezen protective.
Summary of the invention
It is an object of the invention to for deficiency of the prior art, a kind of dewrinkling spot-eliminating essence and preparation method thereof is provided, the dewrinkling spot-eliminating essence of the present invention can effective activation skin cell, improve skin reconstruction ability, repair and supplement damaged cell tissue, slow down the generation of wrinkle, with dispel dark color pigment, make skin light the clearest, its preparation method is simple, easily operation, it is easy to promote.
The purpose of the present invention is achieved through the following technical solutions:
A kind of dewrinkling spot-eliminating essence, by weight, including following components:
Component A: xanthan gum 2-5 part, glycerol 3-8 part, water 40-65 part.
B component: cetearyl alcohol 1-2.5 part, glyceryl stearate
0.5-3 part, caprylic/capric triglyceride 1-2 part, ethylhexyl palmitate 2-6 part, isononyl isononanoate 2-8 part.
Component C: shea butter 1-5 part, preservative
0.1-0.5 part.
D component: mescenchymal stem cell factor 0.008-3 part, small active peptides
0.001-0.05 part, carnosine 0.001-1 part.
Preferably, the mescenchymal stem cell factor, small active peptides, the weight ratio of carnosine is (60 ~ 1): 1:(10 ~ 1).Small active peptides is a kind of biochemical substances between aminoacid and protein, it it is the fragment of a protein, its simple in construction, molecular weight is little, unsaturated, can be directly entered intracellular with original shape by the infiltration of cell membrane, without again digesting, also without expending energy, therefore small active peptides absorption, convert and utilize, it is all efficient, completely, thoroughly, is directly involved the metabolism of muscle cell, endocrine cell, Skin Cell, participate in the growth of cell, growth, physiological function and division growth links；Carnosine (L-Carnosine), formal name used at school β-alanyl-L-histidin, carnosine has the strongest oxidation resistance, can remove the reactive oxygen free radical (ROS) and alpha-beta unsaturated aldehyde making the fatty acid over oxidation of cell membrane during oxidative stress and formed；(60 ~ 1): 1:(10 ~ 1) the mescenchymal stem cell factor under ratio, small active peptides and carnosine have effect that is the most collaborative and that mutually promote, the mescenchymal stem cell factor, small active peptides and carnosine is made effectively to play respective effect, skin cell activates comprehensively, it is thus achieved that repair efficiently.
Preferably, the mescenchymal stem cell factor is the fat mesenchymal stem cell factor, and the substrate of the fat mesenchymal stem cell factor comes from human body itself, and skin cell is prone to absorb.
Preferably, small active peptides is that molecular weight is little by the high activity peptide of 2～4 Amino acid profiles, its simple in construction, is more easy to penetrate in skin cell, increases the effectiveness of this essence.
Preferably, preservative is 1,2-pentanediol and 1, at least one in 2-hexanediol.
The effect of each component is as follows:
Glycerol has water absorption, put on the skin and can form thin film on skin, there are isolation air and the effect preventing moisture from evaporating, the moisture in air can also be absorbed, it can make skin keep softness, high resilience, is not dried by the infringement such as dust, weather, play prevent skin frostbite effect, essence plays the effect of wetting agent and softening agent.
Xanthan gum can provide excellent stability to essence, and high viscosity when it stands is conducive to stablizing of dispersed oil phase in personal care product, and the shear shinning character wiping the used time then provides good lubrication and skin smoothing effect.
Cetearyl alcohol is the material of a kind of White waxy, it is provided that creamy texture, can help to mix the various compositions in skin care item, form stable mixture.
Glyceryl stearate hydrolysis is good, there is the strongest emulsifiability, has special stability, its heat stability and Viscosity-reducing the strongest, the HLB value of polyglycerin ester is extensive, can reduce the surface tension of water, forms micelle, having decontamination, emulsifying, disperse, wash, moisten, permeate, spread, bubble, antioxygen, viscosity adjustment, sterilize, prevent aging, antistatic, prevent partial crystallization etc. multi-functional, itself is safe and nontoxic, to human non-toxic.
Caprylic/capric triglyceride is easy to be absorbed by the skin, and the uniform and smooth of essence is played well effect, makes skin lubrication glossy, can be as the base material of Moisture factor, for the stabilizer as essence, antifreezing agent, homogeneous agent.
Ethylhexyl palmitate is a kind of yellowish oily liquids, the most oxidizable, invariant color, and good stability has good skin moistening, extension and permeability, moistens and softens skin, again without greasy feeling, being good emollient.
Isononyl isononanoate has many methyl branches structure of uniqueness, dry and comfortable and soft feel, it it is splendid emollient, good to silicone oil intermiscibility, it is possible to resolve the problem that silicone oil low temperature separates out, is stabilizer and the coupling agent of silicone oil, colorant is had good dispersibility, viscosity is low, and skinfeel is salubrious, without greasy feeling.
Shea butter has stronger lock outlet capacity, skin is had good affinity, in addition to as excellent wetting agent and conditioner, or a kind of having helping of curing protrusion effect, the vitamin A in shea butter dispels important improvement effect to many skin defect such as fold, eczemas etc.；Shea butter also has improvement result to treating skin anaphylaxis, chapped skin, skin ulcer, all kinds of scytitis, insect bite and skin burn etc., it can be greatly reduced scar area, rheumatism and myalgia can be treated, in cosmetics, there is skin protection and make the effect of skin rehabilitation.
The preparation method of a kind of dewrinkling spot-eliminating essence, comprises the following steps:
A) each component is weighed by above-mentioned formula；
B) component A is put in vacuum emulsification pot, is heated with stirring to 75～85 DEG C, then proceed to stir 3～9 minutes, be incubated 15～25 minutes, make component the most melted, mix homogeneously, after be cooled to 40～50 DEG C, for adding B component, and melted B component prepares；
C) B component is added while stirring, vacuum homogenizing 5～10 minutes；
D) adding C component, vacuum stirring is uniform；
E) adding D component, the later stage adds D component, and the process time that can avoid early stage is long and makes the mescenchymal stem cell factor, small active peptides and carnosine lose efficacy, and vacuum stirring is uniform, is cooled to 25-35 DEG C, discharging.
Beneficial effects of the present invention: A, B, component C softens and after soft and moist skin, by moisture content, nutrition and D component are locked in skin surface, then small active peptides directly penetrates into skin cell, participate in the metabolism of cell, and promote the infiltration of the mescenchymal stem cell factor, repair and supplementary damaged cell tissue, improve skin reconstruction ability, slow down the generation of wrinkle, with the color element dispelling dark color, carnosine removes the reactive oxygen free radical (ROS) and alpha-beta unsaturated aldehyde making the fatty acid over oxidation of cell membrane during oxidative stress and formed, make skin new life vibrant, colour of skin light is the clearest；The preparation method of the present invention is effectively maintained the active ingredient of essence of the present invention, and step is simple, it is easy to operation, it is easy to promote.
Detailed description of the invention
The invention will be further described with the following Examples.
Embodiment 1
In the present embodiment, a kind of dewrinkling spot-eliminating essence, by weight, including following components:
Component A: xanthan gum 2 parts, glycerol 3 parts, 40 parts of water.
B component: cetearyl alcohol 1 part, glyceryl stearate 0.5 part, caprylic/capric triglyceride 1 part, ethylhexyl palmitate 2 parts, isononyl isononanoate 2 parts.
Component C: shea butter 1 part, 1,2-
Pentanediol 0.1 part.
D component: the fat mesenchymal stem cell factor 0.008 part, small active peptides 0.001 part, carnosine 0.001 part.
Preferably, small active peptides is by the high activity peptide of 2 and 3 Amino acid profiles.
The preparation method of above-mentioned essence, comprises the following steps:
A) each component is weighed by above-mentioned formula；
B) component A is put in vacuum emulsification pot, is heated with stirring to 75 DEG C, then proceed to stir 3 minutes, be incubated 15 minutes, make component the most melted, mix homogeneously, after be cooled to 40 DEG C, for adding B component, and melted B component prepares；
C) B component is added while stirring, vacuum homogenizing 5 minutes；
D) adding C component, vacuum stirring is uniform；
E) adding D component, vacuum stirring is uniform, is cooled to 25 DEG C, discharging.
Embodiment
2
In the present embodiment, a kind of dewrinkling spot-eliminating essence, by weight, including following components:
Component A: xanthan gum 3 parts, glycerol 4 parts, 50 parts of water.
B component: cetearyl alcohol 1.5 parts, glyceryl stearate 1 part, caprylic/capric triglyceride 1.2 parts, ethylhexyl palmitate 3 parts, isononyl isononanoate 3 parts.
Component C: shea butter 2 parts, 1
, 2-pentanediol 0.1 part, 1,2-
Hexanediol 0.1 part.
D component: the fat mesenchymal stem cell factor 0.5 part, small active peptides
0.005 part, it is preferable that small active peptides is by the high activity peptide of 2～4 Amino acid profiles, carnosine 0.005 part.
The preparation method of above-mentioned essence, comprises the following steps:
A) each component is weighed by above-mentioned formula；
B) component A is put in vacuum emulsification pot, is heated with stirring to 80 DEG C, then proceed to stir 4 minutes, be incubated 20 minutes, make component the most melted, mix homogeneously, after be cooled to 45 DEG C, for adding B component, and melted B component prepares；
C) B component is added while stirring, vacuum homogenizing 6 minutes；
D) adding C component, vacuum stirring is uniform；
E) adding D component, the later stage adds D component, and the process time that can avoid early stage is long and makes the mescenchymal stem cell factor, small active peptides and carnosine lose efficacy, and vacuum stirring is uniform, is cooled to 28 DEG C, discharging.
Embodiment
3
In the present embodiment, a kind of dewrinkling spot-eliminating essence, by weight, including following components:
Component A: xanthan gum 4 parts, glycerol 5 parts, 55 parts of water.
B component: cetearyl alcohol 2 parts, glyceryl stearate 1.5 parts, caprylic/capric triglyceride 1.4 parts, ethylhexyl palmitate 4 parts, isononyl isononanoate 5 parts.
Component C: shea butter 3 parts, 1
, 2-hexanediol 0.25 part.
D component: the fat mesenchymal stem cell factor 1 part, small active peptides 0.03 part, carnosine 0.5 part.
Preferably, small active peptides is by the high activity peptide of 2～4 Amino acid profiles.
The preparation method of above-mentioned essence, comprises the following steps:
A) each component is weighed by above-mentioned formula；
B) component A is put in vacuum emulsification pot, is heated with stirring to 80 DEG C, then proceed to stir 6 minutes, be incubated 20 minutes, make component the most melted, mix homogeneously, after be cooled to 45 DEG C, for adding B component, and melted B component prepares；
C) B component is added while stirring, vacuum homogenizing 7 minutes；
D) adding C component, vacuum stirring is uniform；
E) adding D component, the later stage adds D component, and the process time that can avoid early stage is long and makes the mescenchymal stem cell factor, small active peptides and carnosine lose efficacy, and vacuum stirring is uniform, is cooled to 30 DEG C, discharging.
Embodiment
4
In the present embodiment, a kind of dewrinkling spot-eliminating essence, by weight, including following components:
Component A: xanthan gum 4.5 parts, glycerol 7 parts, 60 parts of water.
B component: cetearyl alcohol 2.2 parts, glyceryl stearate 2.5 parts, caprylic/capric triglyceride 1.8 parts, ethylhexyl palmitate 5 parts, isononyl isononanoate 7 parts.
Component C: shea butter 4 parts, 1
, 2-pentanediol 0.1 part, 1,2-
Hexanediol 0.3 part.
D component: the fat mesenchymal stem cell factor 2 parts, small active peptides 0.05 part, it is preferable that small active peptides is by the high activity peptide of 2～4 Amino acid profiles, carnosine 0.8 part.
The preparation method of above-mentioned essence, comprises the following steps:
A) each component is weighed by above-mentioned formula；
B) component A is put in vacuum emulsification pot, is heated with stirring to 80 DEG C, then proceed to stir 8 minutes, be incubated 22 minutes, make component the most melted, mix homogeneously, after be cooled to 46 DEG C, for adding B component, and melted B component prepares；
C) B component is added while stirring, vacuum homogenizing 8 minutes；
D) adding C component, vacuum stirring is uniform；
E) adding D component, the later stage adds D component, and the process time that can avoid early stage is long and makes the mescenchymal stem cell factor, small active peptides and carnosine lose efficacy, and vacuum stirring is uniform, is cooled to 30 DEG C, discharging.
Embodiment
5
In the present embodiment, a kind of dewrinkling spot-eliminating essence, by weight, including following components:
Component A: xanthan gum 5 parts, glycerol 8 parts, 65 parts of water.
B component: cetearyl alcohol 2.5 parts, glyceryl stearate 3 parts, caprylic/capric triglyceride 2 parts, ethylhexyl palmitate 6 parts, isononyl isononanoate 8 parts.
Component C: shea butter 5 parts, 1
, 2-pentanediol 0.3 part, 1,2-
Hexanediol 0.2 part.
D component: the fat mesenchymal stem cell factor 3 parts, small active peptides 0.05 part, it is preferable that small active peptides is by the high activity peptide of 2～4 Amino acid profiles, carnosine 1 part.
The preparation method of above-mentioned essence, comprises the following steps:
A) each component is weighed by above-mentioned formula；
B) component A is put in vacuum emulsification pot, is heated with stirring to 85 DEG C, then proceed to stir 9 minutes, be incubated 25 minutes, make component the most melted, mix homogeneously, after be cooled to 50 DEG C, for adding B component, and melted B component prepares；
C) B component is added while stirring, vacuum homogenizing 10 minutes；
D) adding C component, vacuum stirring is uniform；
E) adding D component, the later stage adds D component, and the process time that can avoid early stage is long and makes the mescenchymal stem cell factor, small active peptides and carnosine lose efficacy, and vacuum stirring is uniform, is cooled to 35 DEG C, discharging.
Dewrinkling spot-eliminating effect experimental
The dewrinkling spot-eliminating effect of the made essence of above-described embodiment is evaluated by experiment on probation, the healthy population choosing 150 35-55 year men and women uses, they are arbitrarily divided into 5 groups, often organize 30 people, experimental group 1 is for using embodiment 1 product, experimental group 2 uses embodiment 2 product, experimental group 3 uses embodiment 3 product, experimental group 4 uses embodiment 4 product, experimental group 5 uses embodiment 5 product, every day is coated with face with essence of the present invention the most each twice, uses one month continuously, and service condition is as shown in the table.
In sum, dewrinkling spot-eliminating essence effective percentage of the present invention reaches 93%, is using after the present invention, and the effect of dewrinkling spot-eliminating will increase and the most obvious in time.
The dewrinkling spot-eliminating effect of the dewrinkling spot-eliminating essence of the present invention is obvious, it is easy to produces, has good dissemination.
Finally should be noted that; above example is only in order to illustrate technical scheme; rather than limiting the scope of the invention; although having made to explain to the present invention with reference to preferred embodiment; it will be understood by those within the art that; technical scheme can be modified or equivalent, without deviating from the spirit and scope of technical solution of the present invention.
Claims (6)
1. a dewrinkling spot-eliminating essence, it is characterised in that: by weight, including following components:
Component A: xanthan gum 2-5 part, glycerol 3-8 part, water 40-65 part；
B component: cetearyl alcohol 1-2.5 part, glyceryl stearate 0.5-3 part, caprylic/capric triglyceride 1-2 part, ethylhexyl palmitate 2-6 part, isononyl isononanoate 2-8 part；
Component C: shea butter 1-5 part, preservative 0.1-0.5 part；
D component: mescenchymal stem cell factor 0.008-3 part, small active peptides 0.001-0.05 part, carnosine 0.001-1 part.
A kind of dewrinkling spot-eliminating essence the most according to claim 1, it is characterised in that: the described mescenchymal stem cell factor, small active peptides, the weight ratio of carnosine is (60 ~ 1): 1:(10 ~ 1).
A kind of dewrinkling spot-eliminating essence the most according to claim 1 and 2, it is characterised in that: the described mescenchymal stem cell factor is the fat mesenchymal stem cell factor.
A kind of dewrinkling spot-eliminating essence the most according to claim 1 and 2, it is characterised in that: described small active peptides is by the high activity peptide of 2～4 Amino acid profiles.
A kind of dewrinkling spot-eliminating essence the most according to claim 1, it is characterised in that: described preservative is 1,2-pentanediol and 1, at least one in 2-hexanediol.
6. the preparation method of a dewrinkling spot-eliminating essence, it is characterised in that: comprise the following steps:
Formula according to claim 1 weighs each component；
Component A is put in vacuum emulsification pot, be heated with stirring to 75～85 DEG C, then proceed to stir 3～9 minutes, after being incubated 15～25 minutes, be cooled to 40～50 DEG C；
Add B component, vacuum homogenizing 5～10 minutes while stirring
；
Adding C component, vacuum stirring is uniform；
Adding D component, vacuum stirring is uniform, is cooled to 25-35 DEG C, discharging.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106344493A (en) * | 2016-10-12 | 2017-01-25 | 领航干细胞再生医学工程有限公司 | Preparation method of essence containing human mesenchymal stem cell factors |
| CN109394639A (en) * | 2018-11-12 | 2019-03-01 | 广东科玮生物技术股份有限公司 | A kind of anti-ageing activating essence and preparation method thereof containing ferment |
| CN111956585A (en) * | 2020-08-10 | 2020-11-20 | 湖南本美生物科技有限公司 | Carnosine freckle removing liquid and preparation method thereof |
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| KR20100096447A (en) * | 2009-02-24 | 2010-09-02 | 주식회사 알앤엘바이오 | Cosmetic composition comprising matrials cultured adult stem cells derived from swine placenta tissue and proteins extracted therefrom |
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| CN103784474A (en) * | 2014-01-26 | 2014-05-14 | 广州赛莱拉生物科技有限公司 | Human fat mesenchymal stem cell extract and lyophilized powder and application thereof |
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| WO2010067212A2 (en) * | 2008-12-12 | 2010-06-17 | Labo Cosprophar Ag | A complex of active vegetal stem cells and a cosmetic composition |
| KR20100096447A (en) * | 2009-02-24 | 2010-09-02 | 주식회사 알앤엘바이오 | Cosmetic composition comprising matrials cultured adult stem cells derived from swine placenta tissue and proteins extracted therefrom |
| CN102670438A (en) * | 2012-04-25 | 2012-09-19 | 珠海市时代经典化妆品有限公司 | Anti-ageing skincare product and preparation method thereof |
| CN103735470A (en) * | 2014-01-23 | 2014-04-23 | 广州丹奇日用化工厂有限公司 | Two-phase cosmetic containing apple stem cell extract and preparation method thereof |
| CN103784474A (en) * | 2014-01-26 | 2014-05-14 | 广州赛莱拉生物科技有限公司 | Human fat mesenchymal stem cell extract and lyophilized powder and application thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106344493A (en) * | 2016-10-12 | 2017-01-25 | 领航干细胞再生医学工程有限公司 | Preparation method of essence containing human mesenchymal stem cell factors |
| CN109394639A (en) * | 2018-11-12 | 2019-03-01 | 广东科玮生物技术股份有限公司 | A kind of anti-ageing activating essence and preparation method thereof containing ferment |
| CN111956585A (en) * | 2020-08-10 | 2020-11-20 | 湖南本美生物科技有限公司 | Carnosine freckle removing liquid and preparation method thereof |
| CN111956585B (en) * | 2020-08-10 | 2021-04-30 | 湖南本美生物科技有限公司 | Carnosine freckle removing liquid and preparation method thereof |
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| CN105963163B (en) | 2018-12-14 |
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