CN105934425B - Ebna1抑制剂和其使用方法 - Google Patents

Ebna1抑制剂和其使用方法 Download PDF

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CN105934425B
CN105934425B CN201480073152.2A CN201480073152A CN105934425B CN 105934425 B CN105934425 B CN 105934425B CN 201480073152 A CN201480073152 A CN 201480073152A CN 105934425 B CN105934425 B CN 105934425B
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benzoic acid
indol
ethynyl
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formula
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CN105934425A (zh
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T·E·梅西克
G·R·史密斯
A·B·莱兹
P·M·利伯曼
M·E·麦克唐纳
Y·张
V·维拉德普
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Wistar Institute of Anatomy and Biology
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BR112016011079A2 (pt) 2013-11-15 2017-12-05 Wistar Inst ?inibidores de ebna1 e seu método de uso?
MX2017014550A (es) * 2015-05-14 2018-02-26 Wistar Inst Inhibidores del antigeno nuclear epstein-barr 1 (ebna1) y metodos que los utilizan.
WO2017100819A1 (en) * 2015-12-14 2017-06-22 The Australian National University Modular syntheses of discoipyrrole type alkaloids and analogues
US11046731B2 (en) * 2018-01-18 2021-06-29 Hong Kong Baptist University Zinc-binder based EBNA1-specific compounds
CA3103020A1 (en) * 2018-04-30 2019-11-07 The Trustees Of Indiana University Compounds for modulating ddah and adma levels, as well as methods of using thereof to treat disease
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CN115141176B (zh) * 2021-03-31 2023-08-22 药雅科技(上海)有限公司 炔代吲哚类fgfr抑制剂及其制备方法和用途
CN116135850A (zh) * 2021-11-16 2023-05-19 深圳湾实验室 抗鼻咽癌的小分子抑制剂、化合物的制备方法及其应用
WO2024050408A1 (en) * 2022-08-30 2024-03-07 The Wistar Institute Of Anatomy And Biology Development of a novel ebna-1 degrader targeting through mdm2
CN117586230B (zh) * 2023-10-20 2024-09-24 南方医科大学深圳医院 降解ebna1的protac化合物及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030199511A1 (en) * 2001-12-13 2003-10-23 Qun Li Kinase inhibitors

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3710795A (en) 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
HU190007B (en) * 1982-05-06 1986-08-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for producing new aromatic prostacylin analogues
DE3936297A1 (de) * 1989-11-01 1991-05-02 Bayer Ag Verfahren zur herstellung von symmetrischen diarylacetylenen
DE4039448A1 (de) 1990-12-11 1992-06-17 Rhein Chemie Rheinau Gmbh Polyurethan-katalysatoren
US5356919A (en) * 1991-05-30 1994-10-18 G. D. Searle & Co. Leukotriene B4 synthesis inhibitors
US6166028A (en) * 1998-12-09 2000-12-26 American Home Products Corporation Diaminopuridine-containing thiourea inhibitors of herpes viruses
HN2001000008A (es) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
DE10021246A1 (de) * 2000-04-25 2001-10-31 Schering Ag Substituierte Benzoesäureamide und deren Verwendung als Arzneimittel
HU227630B1 (hu) 2000-05-22 2011-10-28 Aventis Pharma Inc Arilmetilamin-származékok triptáz gátlóként való alkalmazásra és ezeket tartalmazó gyógyszerkészítmények
GB0012362D0 (en) * 2000-05-22 2000-07-12 Aventis Pharma Ltd Chemical compounds
DE60140495D1 (de) 2000-05-31 2009-12-24 Santen Pharmaceutical Co Ltd 1-Ä(adamantyl)alkylÜ-3-Ä(pyridinyl)alkylÜHarnstoff-Verbindungen als TNF-.alpha Hemmer zur Behandlung von Autoimmunerkrankungen
US20040044041A1 (en) * 2002-08-06 2004-03-04 Kuduk Scott D. 2-(Biarylalkyl)amino-3-(cyanoalkanoylamino)pyridine derivatives
US7361743B2 (en) 2004-02-11 2008-04-22 Pfizer Inc Lincomycin derivatives possessing antibacterial activity
CN1288117C (zh) 2004-04-02 2006-12-06 中国科学院上海有机化学研究所 端基炔烃和芳基卤化物的偶联反应
AU2005259835B2 (en) * 2004-07-02 2011-07-07 The Walter And Eliza Hall Institute Of Medical Research Alpha-helical mimetics
EP1771169A1 (en) * 2004-07-14 2007-04-11 PTC Therapeutics, Inc. Methods for treating hepatitis c
CN1993323B (zh) * 2004-08-05 2011-04-20 霍夫曼-拉罗奇有限公司 吲哚,吲唑或二氢吲哚衍生物
EP1879898A2 (en) * 2005-05-12 2008-01-23 Wyeth a Corporation of the State of Delaware Pyrrolobenzodiazepines and heterocyclic carboxamide derivatives as follicle stimulating hormone receptor (fsh-r) antagonists
PL1893612T3 (pl) * 2005-06-22 2012-01-31 Plexxikon Inc Pochodne pirolo-[2,3-b]pirydyny jako inhibitory kinazy białkowej
WO2007002587A2 (en) 2005-06-24 2007-01-04 The Brigham And Women's Hospital, Inc. Inhibitors of epstein barr virus nuclear antigen 1
WO2007023242A1 (en) * 2005-08-24 2007-03-01 Merz Pharma Gmbh & Co. Kgaa Tetrahydroquinolinones and their use as modulators of metabotropic glutamate receptors
WO2008059513A2 (en) * 2006-07-31 2008-05-22 Cadila Healthcare Limited Compounds suitable as modulators of hdl
US7956216B2 (en) * 2006-12-21 2011-06-07 The Walter And Eliza Hall Institute Of Medical Research Alpha-helical mimetics
BRPI0919920A2 (pt) 2008-10-22 2016-02-16 Acucela Inc compostos para tratamento de doenças e desordens oftálmicas
US8273769B2 (en) 2009-02-12 2012-09-25 Merck Serono Sa Phenoxy acetic acid derivatives
WO2010100475A1 (en) * 2009-03-02 2010-09-10 Astrazeneca Ab Hydroxamic acid derivatives as gram-negative antibacterial agents
US8927576B2 (en) * 2009-04-06 2015-01-06 PTC Therpeutics, Inc. HCV inhibitor and therapeutic agent combinations
US20100273772A1 (en) * 2009-04-23 2010-10-28 Wyeth Llc Bisaryl Alkynylamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5 (MGLUR5)
DK2427416T3 (en) 2009-05-04 2016-06-13 Prometic Pharma Smt Ltd Substituted aromatic compounds, and pharmaceutical uses thereof
US9180127B2 (en) 2009-12-29 2015-11-10 Dana-Farber Cancer Institute, Inc. Type II Raf kinase inhibitors
WO2011082098A1 (en) 2009-12-30 2011-07-07 The Rockefeller University Lysine and arginine methyltransferase inhibitors for treating cancer
WO2011090911A1 (en) * 2010-01-19 2011-07-28 Amgen Inc. Amino heteroaryl compounds as beta-secretase modulators and methods of use
CN103502217B (zh) * 2011-01-21 2015-11-25 太阳医药高级研究有限公司 包含酪氨酸激酶抑制剂的二芳基乙炔酰肼
WO2012162291A1 (en) * 2011-05-24 2012-11-29 The Wistar Institute Compositions and methods for modulating the activity of epstein-barr nuclear antigen 1
WO2014145022A1 (en) * 2013-03-15 2014-09-18 President And Fellows Of Harvard College Hybrid necroptosis inhibitors
BR112016011079A2 (pt) * 2013-11-15 2017-12-05 Wistar Inst ?inibidores de ebna1 e seu método de uso?

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030199511A1 (en) * 2001-12-13 2003-10-23 Qun Li Kinase inhibitors

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