CA2930584A1 - Ebna1 inhibitors and their method of use - Google Patents

Ebna1 inhibitors and their method of use Download PDF

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Publication number
CA2930584A1
CA2930584A1 CA2930584A CA2930584A CA2930584A1 CA 2930584 A1 CA2930584 A1 CA 2930584A1 CA 2930584 A CA2930584 A CA 2930584A CA 2930584 A CA2930584 A CA 2930584A CA 2930584 A1 CA2930584 A1 CA 2930584A1
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Prior art keywords
benzoic acid
ethynyl
phenylethynyl
pyrrol
compound
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Abandoned
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CA2930584A
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English (en)
French (fr)
Inventor
Troy E. Messick
Garry R. Smith
Allen B. Reitz
Paul M. Lieberman
Mark E. Mcdonnell
Yan Zhang
Venkata Velvadapu
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The Wistar Institute
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The Wistar Institute
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Publication of CA2930584A1 publication Critical patent/CA2930584A1/en
Abandoned legal-status Critical Current

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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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WO2017100819A1 (en) * 2015-12-14 2017-06-22 The Australian National University Modular syntheses of discoipyrrole type alkaloids and analogues
US11046731B2 (en) * 2018-01-18 2021-06-29 Hong Kong Baptist University Zinc-binder based EBNA1-specific compounds
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CN115141176B (zh) * 2021-03-31 2023-08-22 药雅科技(上海)有限公司 炔代吲哚类fgfr抑制剂及其制备方法和用途
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