CN105903018A - 一种具有美白效果的针剂 - Google Patents
一种具有美白效果的针剂 Download PDFInfo
- Publication number
- CN105903018A CN105903018A CN201610323460.7A CN201610323460A CN105903018A CN 105903018 A CN105903018 A CN 105903018A CN 201610323460 A CN201610323460 A CN 201610323460A CN 105903018 A CN105903018 A CN 105903018A
- Authority
- CN
- China
- Prior art keywords
- injection
- skin
- whitening effect
- vitamin
- kinds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002087 whitening effect Effects 0.000 title claims abstract description 27
- 238000002347 injection Methods 0.000 title claims abstract description 23
- 239000007924 injection Substances 0.000 title claims abstract description 23
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 18
- 150000001413 amino acids Chemical class 0.000 claims abstract description 15
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 9
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 9
- 239000011718 vitamin C Substances 0.000 claims abstract description 9
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims abstract description 7
- 229930003270 Vitamin B Natural products 0.000 claims abstract description 6
- 150000001875 compounds Chemical class 0.000 claims abstract description 6
- 229960003180 glutathione Drugs 0.000 claims abstract description 6
- 235000019156 vitamin B Nutrition 0.000 claims abstract description 6
- 239000011720 vitamin B Substances 0.000 claims abstract description 6
- 229940024606 amino acid Drugs 0.000 claims description 15
- 235000001014 amino acid Nutrition 0.000 claims description 15
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims description 10
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 8
- 241000218628 Ginkgo Species 0.000 claims description 6
- 235000011201 Ginkgo Nutrition 0.000 claims description 6
- 235000008100 Ginkgo biloba Nutrition 0.000 claims description 6
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 6
- -1 Valine Chemical compound 0.000 claims description 6
- 210000000582 semen Anatomy 0.000 claims description 6
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims description 5
- QDGAVODICPCDMU-UHFFFAOYSA-N 2-amino-3-[3-[bis(2-chloroethyl)amino]phenyl]propanoic acid Chemical compound OC(=O)C(N)CC1=CC=CC(N(CCCl)CCCl)=C1 QDGAVODICPCDMU-UHFFFAOYSA-N 0.000 claims description 5
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 5
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims description 5
- 229930064664 L-arginine Natural products 0.000 claims description 5
- 235000014852 L-arginine Nutrition 0.000 claims description 5
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 5
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 5
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 5
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 5
- 239000004473 Threonine Substances 0.000 claims description 5
- 101710147108 Tyrosinase inhibitor Proteins 0.000 claims description 5
- 235000004279 alanine Nutrition 0.000 claims description 5
- 235000003969 glutathione Nutrition 0.000 claims description 5
- 229930182817 methionine Natural products 0.000 claims description 5
- 229960001153 serine Drugs 0.000 claims description 5
- 229960002898 threonine Drugs 0.000 claims description 5
- 239000004471 Glycine Substances 0.000 claims description 4
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims description 4
- RRNJROHIFSLGRA-JEDNCBNOSA-N acetic acid;(2s)-2,6-diaminohexanoic acid Chemical compound CC(O)=O.NCCCC[C@H](N)C(O)=O RRNJROHIFSLGRA-JEDNCBNOSA-N 0.000 claims description 4
- 229960005357 lysine acetate Drugs 0.000 claims description 4
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 3
- 229960002885 histidine Drugs 0.000 claims description 3
- 229960004452 methionine Drugs 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 12
- 208000003351 Melanosis Diseases 0.000 abstract description 6
- 206010008570 Chloasma Diseases 0.000 abstract description 5
- 102000003425 Tyrosinase Human genes 0.000 abstract description 5
- 108060008724 Tyrosinase Proteins 0.000 abstract description 5
- 239000000049 pigment Substances 0.000 abstract description 5
- 230000015572 biosynthetic process Effects 0.000 abstract description 3
- 239000000284 extract Substances 0.000 abstract description 2
- YLKVIMNNMLKUGJ-FPLPWBNLSA-N (15:1)-Cardanol Chemical compound CCCCCC\C=C/CCCCCCCC1=CC=CC(O)=C1 YLKVIMNNMLKUGJ-FPLPWBNLSA-N 0.000 abstract 1
- YLKVIMNNMLKUGJ-UHFFFAOYSA-N 3-Delta8-pentadecenylphenol Natural products CCCCCCC=CCCCCCCCC1=CC=CC(O)=C1 YLKVIMNNMLKUGJ-UHFFFAOYSA-N 0.000 abstract 1
- 108010024636 Glutathione Proteins 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 25
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 8
- 241000196324 Embryophyta Species 0.000 description 7
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 6
- 239000000178 monomer Substances 0.000 description 5
- DWNBOPVKNPVNQG-LURJTMIESA-N (2s)-4-hydroxy-2-(propylamino)butanoic acid Chemical compound CCCN[C@H](C(O)=O)CCO DWNBOPVKNPVNQG-LURJTMIESA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 229910021529 ammonia Inorganic materials 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000002085 irritant Substances 0.000 description 2
- 231100000021 irritant Toxicity 0.000 description 2
- 210000002752 melanocyte Anatomy 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 235000002673 Dioscorea communis Nutrition 0.000 description 1
- 241000544230 Dioscorea communis Species 0.000 description 1
- 208000035753 Periorbital contusion Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 210000002780 melanosome Anatomy 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
- A61K36/8905—Cyperus (flatsedge)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cosmetics (AREA)
Abstract
本发明公开了一种具有美白效果的针剂，其包括以下质量的组分：谷胱甘肽1000‑2000mg、酪氨酸酶抑制剂100‑600mg、维他命C 200‑800mg、银杏提取物2‑100mg、复合维生素B 1‑20mg、等质量的15种氨基酸100‑600mg。本发明能抑制酪氨酸酶活性，治愈黄褐斑和色斑，减少黑色素形成，并且降低其活性，改善局部肤块的黯沉，提亮整体肤色透明感，让肌肤呈现很好的美白效果；本发明与一般传统的美白产品相比，具有安全、没有刺激的优点，能够适合各种类型的肌肤，有较强的稳定性，不易受温度影响。
Description
技术领域
本发明涉及医药技术领域，具体来说，涉及一种具有美白效果的针剂。
背景技术
近年来随着人口老化、环境污染、全球气温上升越来越多的人们皮肤上出现色素形成失调，皮肤的褐斑、雀斑已成为严重的皮肤困扰。特别是褐斑、雀斑以及日晒后皮肤上的黑色色素沉着会随年龄增加而产生、增加，同时越来越难以消除，因而成为人们无法避免的烦恼。皮肤上沉着的黑色色素几乎全是黑色素，其在表皮和真皮之间的黑素细胞内的黑素体中产生，生成的黑素通过渗透作用向相邻细胞扩散。目前市场上出现的美白护肤品，成分中一般包括植物单体、维生素C或氨基酸。
植物单体：植物单体是一种植物的提取物，其成份相对温和和安全，经常是由多种成分混合在一起。植物单体是通过抑制酪氨酸酶的活性，达到其美白的效果，这些有美白效果的植物单体往往也具有消炎的作用，通常被使用的植物包括甘草、木瓜、黄瓜，银杏，虽然有很多优点，但是美白效果很差，而且很慢。
维生素C：维生素C是一种很强的还原剂，具有抗氧化作，较为安全和温和，但是，其美白的效力和其分子结构有关，其结构不稳定，怕热怕光易氧化，因此不容易使用。
氨基酸：氨基酸是一种复合型的氨基酸，其和皮肤中的胶原蛋白有比较大的亲和力，其分子量越大，其亲和作用随之增强，分子量小的分子可以渗入皮肤的终末毛细血管，营养血管，抑制黑色素的形成。氨基酸虽然可以增白、保湿、消除黑眼圈。但是往往效果不明显，效果很慢。
针对相关技术中的问题，目前尚未提出有效的解决方案。
发明内容
针对相关技术中的上述技术问题，本发明提出一种具有美白效果的针剂，能够抑制酪氨酸酶活性、治愈黄褐斑和色斑、减少黑色素形成，并且降低其活性、改善局部肤块的黯沉，提亮整体肤色透明感。
为实现上述技术目的，本发明的技术方案是这样实现的：
一种具有美白效果的针剂，其包括以下质量的组分：谷胱甘肽1000-2000mg、酪氨酸酶抑制剂100-600mg、维他命C 200-800mg、银杏提取物2-100mg、复合维生素B 1-20mg、等质量的15种氨基酸100-600mg，所述15种氨基酸包括：L-异亮氨酸、L-缬氨酸、L-亮氨酸、L-丙氨酸、L-赖氨酸、L-精氨酸、醋酸赖氨酸、L-组氨酸、甲硫氨酸、L-丝氨酸、L-苯丙氨酸、L-脯氨酸、L-苏氨酸、甘氨酸、L-色氨酸。
本发明的有益效果：本发明能抑制酪氨酸酶活性，治愈黄褐斑和色斑，减少黑色素形成，并且降低其活性，改善局部肤块的黯沉，提亮整体肤色透明感，让肌肤呈现很好的美白效果；本发明与一般传统的美白产品相比，具有安全、没有刺激的优点，能够适合各种类型的肌肤，有较强的稳定性，不易受温度影响。
具体实施方式
实施例1
本发明实施例所述的一种具有美白效果的针剂，其包括以下质量的组分：谷胱甘肽1000mg、酪氨酸酶抑制剂100mg、维他命C 200mg、银杏提取物2mg、复合维生素B 1mg、等质量的15种氨基酸600mg，所述15种氨基酸包括：L-异亮氨酸、L-缬氨酸、L-亮氨酸、L-丙氨酸、L-赖氨酸、L-精氨酸、醋酸赖氨酸、L-组氨酸、甲硫氨酸、L-丝氨酸、L-苯丙氨酸、L-脯氨酸、L-苏氨酸、甘氨酸、L-色氨酸。
实施例2
一种具有美白效果的针剂，其包括以下质量的组分：谷胱甘肽1500mg、酪氨酸酶抑制剂350mg、维他命C 500mg、银杏提取物50mg、复合维生素B10.5mg、等质量的15种氨基酸100mg，所述15种氨基酸包括：L-异亮氨酸、L-缬氨酸、L-亮氨酸、L-丙氨酸、L-赖氨酸、L-精氨酸、醋酸赖氨酸、L-组氨酸、甲硫氨酸、L-丝氨酸、L-苯丙氨酸、L-脯氨酸、L-苏氨酸、甘氨酸、L-色氨酸；所述具有美白效果的针剂以注射液方式存在。
实施例3
一种具有美白效果的针剂，其包括以下质量的组分：谷胱甘肽2000mg、酪氨酸酶抑制剂600mg、维他命C 800mg、银杏提取物10mg、复合维生素B20mg、等质量的15种氨基酸350mg，所述15种氨基酸包括：L-异亮氨酸、L-缬氨酸、L-亮氨酸、L-丙氨酸、L-赖氨酸、L-精氨酸、醋酸赖氨酸、L-组氨酸、甲硫氨酸、L-丝氨酸、L-苯丙氨酸、L-脯氨酸、L-苏氨酸、甘氨酸、L-色氨酸；所述具有美白效果的针剂以注射液方式存在。
实例
本发明人于2009年至今对180例门诊患者进行临床观察治疗，年龄19到55岁不等，总有效率为100％。
使用方法：每个疗程，使用4次注射针剂，注射每次之间的间隔12天。
疗效评定标准：
肤色暗黄：改善皮肤发暗的状况，肌肤变白，通透有光泽；
皮肤有黄褐斑：黑色素形成减少，肌肤呈现很好的美白效果。
治疗效果如表1所示：
表1皮肤美白效果改善表
本发明能抑制酪氨酸酶活性，治愈黄褐斑和色斑，减少黑色素形成，并且降低其活性，改善局部肤块的黯沉，提亮整体肤色透明感，让肌肤呈现很好的美白效果；本发明与一般传统的美白产品相比，具有安全、没有刺激的优点，能够适合各种类型的肌肤，有较强的稳定性，不易受温度影响。
以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。
Claims (2)
1.一种具有美白效果的针剂，其特征在于，其包括以下质量的组分：谷胱甘肽1000-2000mg、酪氨酸酶抑制剂100-600mg、维他命C 200-800mg、银杏提取物2-100mg、复合维生素B 1-20mg、等质量的15种氨基酸100-600mg，所述的15种氨基酸是：L-异亮氨酸、L-缬氨酸、L-亮氨酸、L-丙氨酸、L-赖氨酸、L-精氨酸、醋酸赖氨酸、L-组氨酸、甲硫氨酸、L-丝氨酸、L-苯丙氨酸、L-脯氨酸、L-苏氨酸、甘氨酸、L-色氨酸。
2.根据权利要求1所述的具有美白效果的针剂，其特征在于，所述具有美白效果的针剂以注射液方式存在。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610323460.7A CN105903018A (zh) | 2016-05-16 | 2016-05-16 | 一种具有美白效果的针剂 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610323460.7A CN105903018A (zh) | 2016-05-16 | 2016-05-16 | 一种具有美白效果的针剂 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105903018A true CN105903018A (zh) | 2016-08-31 |
Family
ID=56748230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610323460.7A Pending CN105903018A (zh) | 2016-05-16 | 2016-05-16 | 一种具有美白效果的针剂 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105903018A (zh) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107823632A (zh) * | 2017-11-10 | 2018-03-23 | 南京九圣生物科技股份有限公司 | 一种骨髓间充质干细胞注射液及制备方法 |
| CN108261341A (zh) * | 2018-02-12 | 2018-07-10 | 苏州纳晶医药技术有限公司 | 双组份用于纠正皮肤皱纹的美白长效水光针剂 |
| CN113244160A (zh) * | 2021-05-31 | 2021-08-13 | 美卓(杭州)医疗科技有限公司 | 一种多效护肤注射液及其制备方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102698251A (zh) * | 2012-06-09 | 2012-10-03 | 东莞市照燕生物科技有限公司 | 一种排毒美白的注射针剂 |
| CN102846499A (zh) * | 2012-08-14 | 2013-01-02 | 王青 | 一种具有美白祛斑换肤作用的组合物 |
| CN103347486A (zh) * | 2011-01-20 | 2013-10-09 | 株式会社日冷生物科学 | 含有3-羟基-2-吡喃酮的美白剂 |
| CN103893075A (zh) * | 2014-04-21 | 2014-07-02 | 田晓艳 | 氨基酸复合中药祛斑去黄美白面膜 |
-
2016
- 2016-05-16 CN CN201610323460.7A patent/CN105903018A/zh active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103347486A (zh) * | 2011-01-20 | 2013-10-09 | 株式会社日冷生物科学 | 含有3-羟基-2-吡喃酮的美白剂 |
| CN102698251A (zh) * | 2012-06-09 | 2012-10-03 | 东莞市照燕生物科技有限公司 | 一种排毒美白的注射针剂 |
| CN102846499A (zh) * | 2012-08-14 | 2013-01-02 | 王青 | 一种具有美白祛斑换肤作用的组合物 |
| CN103893075A (zh) * | 2014-04-21 | 2014-07-02 | 田晓艳 | 氨基酸复合中药祛斑去黄美白面膜 |
Non-Patent Citations (3)
| Title |
|---|
| 卢静怡: "《原来皮肤还有这么多秘密》", 30 September 2012, 华中师范大学出版社 * |
| 彭红华，等: "《中医美容技术》", 28 February 2013, 西安交通大学出版社 * |
| 白白（李依璇）: "《美白教主》", 31 December 2011, 漓江出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107823632A (zh) * | 2017-11-10 | 2018-03-23 | 南京九圣生物科技股份有限公司 | 一种骨髓间充质干细胞注射液及制备方法 |
| CN108261341A (zh) * | 2018-02-12 | 2018-07-10 | 苏州纳晶医药技术有限公司 | 双组份用于纠正皮肤皱纹的美白长效水光针剂 |
| CN113244160A (zh) * | 2021-05-31 | 2021-08-13 | 美卓(杭州)医疗科技有限公司 | 一种多效护肤注射液及其制备方法 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108852894A (zh) | 一种用于修复美白祛皱的多肽组合 | |
| CN110302071A (zh) | 蓝光防护化妆品组合物及其制备方法和包含有该组合物的化妆品 | |
| JP2011516585A (ja) | スキンケア組成物およびその使用方法 | |
| CN105903018A (zh) | 一种具有美白效果的针剂 | |
| JP5348512B2 (ja) | 染毛剤組成物 | |
| KR101196523B1 (ko) | 천연물 발효 추출물을 유효성분으로 하는 발모제 조성물 | |
| CN109288715A (zh) | 一种美白修复组合物及其制备方法 | |
| CN102973467A (zh) | 棕红色系植物生态染发剂及其制备方法 | |
| JP2002138024A (ja) | 染毛剤、染毛用セットおよびそれを用いた染毛方法 | |
| CN108113920A (zh) | 一种缓释美白复合保湿面霜基质及其制备方法和应用 | |
| JP2020132577A (ja) | 髪トリートメント組成物 | |
| JP2008290977A (ja) | 毛髪保護組成物、毛髪化粧料、及び毛髪の保護方法 | |
| JP3834570B2 (ja) | 染毛効果を有する養毛・育毛剤 | |
| CN109350572A (zh) | 一种祛红血丝的化妆品组合物及其制备方法和应用 | |
| TWI641391B (zh) | Skin external preparation for facial use with amino acid | |
| JP3542107B2 (ja) | 染毛剤およびそれを用いた染毛方法 | |
| CN106806333A (zh) | 一种具有美白及祛斑功能的组合物及其应用 | |
| JP4287719B2 (ja) | 染毛剤およびそれを用いた染毛方法 | |
| CN107049911A (zh) | 一种治疗红血丝的组合物及其应用 | |
| JP5991513B2 (ja) | 白髪の染毛方法 | |
| JPH1149652A (ja) | 永久又は半永久染毛剤組成物 | |
| US20150182442A1 (en) | Traditional chinese medicine composition that has the effect of soothing and cleaning face | |
| CN101822624B (zh) | 一种含有硫辛酸和丹参提取物的组合物及其在化妆品中的应用 | |
| KR20150079246A (ko) | 미백효과를 가지는 복합 약재 추출물을 함유하는 화장료 조성물 | |
| JPH10130129A (ja) | 染毛用組成物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160831 |