CN105902848A - Damp-heat accumulation and stagnation caused sicca syndrome treating traditional Chinese medicine composition and preparation method thereof - Google Patents
Damp-heat accumulation and stagnation caused sicca syndrome treating traditional Chinese medicine composition and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a damp-heat accumulation and stagnation caused sicca syndrome treating traditional Chinese medicine composition which comprises, by weight, 8-11 parts of Radix Gentianae, 14-17 parts of Fructus Tritici Levis, 12-15 parts of Radix Trichosanthis, 6-8 parts of Radix Scutellariae, 10-14 parts of Radix Ophiopogonis, 2-5 parts of Cortex Magnoliae Officinalis, 9-12 parts of bark of Ivy tree and 1-3 parts of Fructus Piperis Longi. The invention further provides a preparation method of the damp-heat accumulation and stagnation caused sicca syndrome treating traditional Chinese medicine composition. The damp-heat accumulation and stagnation caused sicca syndrome treating traditional Chinese medicine composition has good treatment effect to damp-heat accumulation and stagnation caused sicca syndrome, remarkable efficacy and low toxic and side effect, and treats both symptoms and root causes so that disease recurrence is avoided after cured.
Description
Technical field
The present invention relates to the field of Chinese medicines, a kind of treat damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome and preparation method thereof.
Background technology
Dry syndrome is a kind of to invade the chronic auto-immune disease of the exocrine gland such as lachrymal gland, salivary gland, is also called autoimmunity exocrine gland sick.Mainly show as drying property cornea, conjunctivitis, xerostomia or other rheumatism such as rheumatoid arthritis that occur together, it can involve other system and such as breathe be, Digestive, urinary system, blood system, nerveous system and muscle, joint etc. cause multisystem, multiple organ impaired.Primary disease sickness rate is high, is mainly in more than 40 years old women.Its pathomechanism, mainly due to autoimmune excessive responsing reaction, causes the big amount lymphocyte of exocrine gland, plasmocyte infiltrating, makes gland cell destroy, afunction, thus a series of clinical symptoms and performance occurs.
Modern medicine is thought, dry syndrome is relevant with dysimmunity, virus infection, inherited genetic factors and gonadal hormone.Primary disease there is no radical cure method at present.Mainly take measures to improve symptom, control and delay progress and secondary infection that the histoorgan caused because of immunoreation damages.
The traditional Chinese medical science is thought, sjogren syndrome belongs to dry numbness category, and the pathogenesis etiology of sjogren syndrome is a lot, clinical symptoms is the most different, wherein, because the damp and hot sjogren syndrome that causes of resistance that accumulates is referred to as damp and hot accumulateing resistance type sjogren syndrome, damp and hot accumulate resistance type sjogren syndrome symptom be: sialosis, mouth xerophthalmia scheorma, bitter taste, halitosis, glutinous greasy discomfort in mouth, bicker has white secretions, puckery pain can be urinated and is difficult to resolve with abdominal distention uncomfortable in chest, or have low grade fever, red tongue, tongue is the most greasy or yellow greasy, slippery and rapid pulse.Western medical treatment and Chinese traditional treatment two kinds is mainly had currently for the damp and hot Therapeutic Method accumulateing resistance type sjogren syndrome, western medical treatment is only capable of alleviating surface symptoms, and curative effect is undesirable, and easily recurs after drug withdrawal, the diagnosis and treatment standard randomness of Chinese traditional treatment is very big, and actual efficacy is the clearest and the most definite.
Summary of the invention
It is an object of the invention to provide and a kind of treat damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome and preparation method thereof, ask damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome for the treatment of and its production and use with solve above-mentioned background technology proposes.
For achieving the above object, the present invention provides following technical scheme:
Treat the damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome, be made up of according to the raw material of weight portion following: Radix Gentianae 8-11 part, Fructus Tritici Levis 14-17 part, Radix Trichosanthis 12-15 part, Radix Scutellariae 6-8 part, 10-14 part Radix Ophiopogonis, Cortex Magnoliae Officinalis 2-5 part, Cortex schefflerae octophyllae 9-12 part, Fructus Piperis Longi 1-3 part.
As the further scheme of the present invention: be made up of according to the raw material of weight portion following: Radix Gentianae 9-10 part, Fructus Tritici Levis 15-16 part, Radix Trichosanthis 13-14 part, Radix Scutellariae 7-8 part, 11-13 part Radix Ophiopogonis, Cortex Magnoliae Officinalis 3-4 part, Cortex schefflerae octophyllae 10-11 part, Fructus Piperis Longi 1-2 part.
As the present invention further scheme: be made up of according to the raw material of weight portion following: Radix Gentianae 9 parts, Fructus Tritici Levis 16 parts, Radix Trichosanthis 13 parts, Radix Scutellariae 7 parts, Radix Ophiopogonis 12 parts, Cortex Magnoliae Officinalis 3 parts, Cortex schefflerae octophyllae 10 parts, Fructus Piperis Longi 2 parts.
The preparation method of the damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome of described treatment, step is as follows:
1) weigh Fructus Tritici Levis, after cleaning-drying, grind, it is thus achieved that Fructus Tritici Levis powder, standby；
2) weigh Radix Gentianae, Radix Scutellariae, Radix Ophiopogonis, Cortex Magnoliae Officinalis, Cortex schefflerae octophyllae and Fructus Piperis Longi, after cleaning, drying, pulverize, mix homogeneously, it is thus achieved that the first mixed-powder, weigh Radix Trichosanthis, Radix Trichosanthis is added to the first mixed-powder, mix homogeneously, it is thus achieved that the second mixed-powder；
3) the second mixed-powder is put into decoction container, adds the water of 10-12 times amount, decoct 2-3h, obtain a decoction liquor and medicinal residues, medicinal residues are added again the water of 6-8 times amount, decoct 1-2h, obtain secondary decoction liquor and secondary medicinal residues, secondary medicinal residues are added 80% ethanol solution of 8-10 times amount, heating and refluxing extraction 50-60min, filters, obtain reflux extracting liquid and three medicinal residues, decoction liquor, secondary decoction liquor and reflux extracting liquid are merged, filters, it is thus achieved that total medicinal liquid；
4) it is dry cream by total medicinal liquid evaporation and concentration；
5) dried cream powder is broken, add Fructus Tritici Levis powder, mix homogeneously, make tablet or capsule, the damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome must be treated.
Above-mentioned Chinese medicine composition can be used in preparation and treats the damp and hot medicine accumulateing resistance type sjogren syndrome.
Compared with prior art, the invention has the beneficial effects as follows:
It is good to the damp and hot therapeutic effect accumulateing resistance type sjogren syndrome that the present invention treats the damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome, and total effective rate has reached 88.9%, evident in efficacy, and toxic and side effects is little, treating both the principal and secondary aspects of a disease, controls difficulty in relapse after healing.
Detailed description of the invention
Below in conjunction with detailed description of the invention, technical scheme is described in more detail.
Embodiment 1
Treat the damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome, be made up of according to the raw material of weight portion following: Radix Gentianae 8 parts, Fructus Tritici Levis 14 parts, Radix Trichosanthis 12 parts, Radix Scutellariae 6 parts, Radix Ophiopogonis 10 parts, Cortex Magnoliae Officinalis 2 parts, Cortex schefflerae octophyllae 9 parts, Fructus Piperis Longi 1 part.
Treating the preparation method of the damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome described in the present embodiment, step is as follows:
1) weigh Fructus Tritici Levis, after cleaning-drying, grind, it is thus achieved that Fructus Tritici Levis powder, standby；
2) weigh Radix Gentianae, Radix Scutellariae, Radix Ophiopogonis, Cortex Magnoliae Officinalis, Cortex schefflerae octophyllae and Fructus Piperis Longi, after cleaning, drying, pulverize, mix homogeneously, it is thus achieved that the first mixed-powder, weigh Radix Trichosanthis, Radix Trichosanthis is added to the first mixed-powder, mix homogeneously, it is thus achieved that the second mixed-powder；
3) the second mixed-powder is put into decoction container, adds the water of 10 times amount, decoct 2h, obtain a decoction liquor and medicinal residues, medicinal residues are added again the water of 6 times amount, decoct 1h, obtain secondary decoction liquor and secondary medicinal residues, secondary medicinal residues are added 80% ethanol solution of 8 times amount, heating and refluxing extraction 50min, filters, obtain reflux extracting liquid and three medicinal residues, decoction liquor, secondary decoction liquor and reflux extracting liquid are merged, filters, it is thus achieved that total medicinal liquid；
4) it is dry cream by total medicinal liquid evaporation and concentration；
5) dried cream powder is broken, add Fructus Tritici Levis powder, mix homogeneously, make tablet, the damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome must be treated.
Embodiment 2
Treat the damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome, be made up of according to the raw material of weight portion following: Radix Gentianae 9 parts, Fructus Tritici Levis 17 parts, Radix Trichosanthis 13 parts, Radix Scutellariae 8 parts, Radix Ophiopogonis 10 parts, Cortex Magnoliae Officinalis 3 parts, Cortex schefflerae octophyllae 12 parts, Fructus Piperis Longi 1 part.
Treating the preparation method of the damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome described in the present embodiment, step is as follows:
1) weigh Fructus Tritici Levis, after cleaning-drying, grind, it is thus achieved that Fructus Tritici Levis powder, standby；
2) weigh Radix Gentianae, Radix Scutellariae, Radix Ophiopogonis, Cortex Magnoliae Officinalis, Cortex schefflerae octophyllae and Fructus Piperis Longi, after cleaning, drying, pulverize, mix homogeneously, it is thus achieved that the first mixed-powder, weigh Radix Trichosanthis, Radix Trichosanthis is added to the first mixed-powder, mix homogeneously, it is thus achieved that the second mixed-powder；
3) the second mixed-powder is put into decoction container, adds the water of 11 times amount, decoct 3h, obtain a decoction liquor and medicinal residues, medicinal residues are added again the water of 8 times amount, decoct 1h, obtain secondary decoction liquor and secondary medicinal residues, secondary medicinal residues are added 80% ethanol solution of 9 times amount, heating and refluxing extraction 55min, filters, obtain reflux extracting liquid and three medicinal residues, decoction liquor, secondary decoction liquor and reflux extracting liquid are merged, filters, it is thus achieved that total medicinal liquid；
4) it is dry cream by total medicinal liquid evaporation and concentration；
5) dried cream powder is broken, add Fructus Tritici Levis powder, mix homogeneously, make capsule, the damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome must be treated.
Embodiment 3
Treat the damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome, be made up of according to the raw material of weight portion following: Radix Gentianae 9 parts, Fructus Tritici Levis 16 parts, Radix Trichosanthis 13 parts, Radix Scutellariae 7 parts, Radix Ophiopogonis 12 parts, Cortex Magnoliae Officinalis 3 parts, Cortex schefflerae octophyllae 10 parts, Fructus Piperis Longi 2 parts.
Treating the preparation method of the damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome described in the present embodiment, step is as follows:
1) weigh Fructus Tritici Levis, after cleaning-drying, grind, it is thus achieved that Fructus Tritici Levis powder, standby；
2) weigh Radix Gentianae, Radix Scutellariae, Radix Ophiopogonis, Cortex Magnoliae Officinalis, Cortex schefflerae octophyllae and Fructus Piperis Longi, after cleaning, drying, pulverize, mix homogeneously, it is thus achieved that the first mixed-powder, weigh Radix Trichosanthis, Radix Trichosanthis is added to the first mixed-powder, mix homogeneously, it is thus achieved that the second mixed-powder；
3) the second mixed-powder is put into decoction container, adds the water of 11 times amount, decoct 2.5h, obtain a decoction liquor and medicinal residues, medicinal residues are added again the water of 7 times amount, decoct 1.5h, obtain secondary decoction liquor and secondary medicinal residues, secondary medicinal residues are added 80% ethanol solution of 9 times amount, heating and refluxing extraction 55min, filters, obtain reflux extracting liquid and three medicinal residues, decoction liquor, secondary decoction liquor and reflux extracting liquid are merged, filters, it is thus achieved that total medicinal liquid；
4) it is dry cream by total medicinal liquid evaporation and concentration；
5) dried cream powder is broken, add Fructus Tritici Levis powder, mix homogeneously, make tablet, the damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome must be treated.
Embodiment 4
Treat the damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome, be made up of according to the raw material of weight portion following: Radix Gentianae 11 parts, Fructus Tritici Levis 15 parts, Radix Trichosanthis 12 parts, Radix Scutellariae 6 parts, Radix Ophiopogonis 12 parts, Cortex Magnoliae Officinalis 5 parts, Cortex schefflerae octophyllae 9 parts, Fructus Piperis Longi 3 parts.
Treating the preparation method of the damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome described in the present embodiment, step is as follows:
1) weigh Fructus Tritici Levis, after cleaning-drying, grind, it is thus achieved that Fructus Tritici Levis powder, standby；
2) weigh Radix Gentianae, Radix Scutellariae, Radix Ophiopogonis, Cortex Magnoliae Officinalis, Cortex schefflerae octophyllae and Fructus Piperis Longi, after cleaning, drying, pulverize, mix homogeneously, it is thus achieved that the first mixed-powder, weigh Radix Trichosanthis, Radix Trichosanthis is added to the first mixed-powder, mix homogeneously, it is thus achieved that the second mixed-powder；
3) the second mixed-powder is put into decoction container, adds the water of 12 times amount, decoct 2h, obtain a decoction liquor and medicinal residues, medicinal residues are added again the water of 7 times amount, decoct 1.5h, obtain secondary decoction liquor and secondary medicinal residues, secondary medicinal residues are added 80% ethanol solution of 10 times amount, heating and refluxing extraction 50min, filters, obtain reflux extracting liquid and three medicinal residues, decoction liquor, secondary decoction liquor and reflux extracting liquid are merged, filters, it is thus achieved that total medicinal liquid；
4) it is dry cream by total medicinal liquid evaporation and concentration；
5) dried cream powder is broken, add Fructus Tritici Levis powder, mix homogeneously, make capsule, the damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome must be treated.
Embodiment 5
Treat the damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome, be made up of according to the raw material of weight portion following: Radix Gentianae 11 parts, Fructus Tritici Levis 17 parts, Radix Trichosanthis 15 parts, Radix Scutellariae 8 parts, Radix Ophiopogonis 14 parts, Cortex Magnoliae Officinalis 5 parts, Cortex schefflerae octophyllae 12 parts, Fructus Piperis Longi 3 parts.
Treating the preparation method of the damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome described in the present embodiment, step is as follows:
1) weigh Fructus Tritici Levis, after cleaning-drying, grind, it is thus achieved that Fructus Tritici Levis powder, standby；
2) weigh Radix Gentianae, Radix Scutellariae, Radix Ophiopogonis, Cortex Magnoliae Officinalis, Cortex schefflerae octophyllae and Fructus Piperis Longi, after cleaning, drying, pulverize, mix homogeneously, it is thus achieved that the first mixed-powder, weigh Radix Trichosanthis, Radix Trichosanthis is added to the first mixed-powder, mix homogeneously, it is thus achieved that the second mixed-powder；
3) the second mixed-powder is put into decoction container, adds the water of 12 times amount, decoct 3h, obtain a decoction liquor and medicinal residues, medicinal residues are added again the water of 8 times amount, decoct 2h, obtain secondary decoction liquor and secondary medicinal residues, secondary medicinal residues are added 80% ethanol solution of 10 times amount, heating and refluxing extraction 60min, filters, obtain reflux extracting liquid and three medicinal residues, decoction liquor, secondary decoction liquor and reflux extracting liquid are merged, filters, it is thus achieved that total medicinal liquid；
4) it is dry cream by total medicinal liquid evaporation and concentration；
5) dried cream powder is broken, add Fructus Tritici Levis powder, mix homogeneously, make capsule, the damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome must be treated.
Comparative example
It is made up of according to the raw material of weight portion following: Radix Gentianae 9 parts, Fructus Tritici Levis 16 parts, Radix Trichosanthis 13 parts, Radix Scutellariae 7 parts, Radix Ophiopogonis 12 parts, Cortex Magnoliae Officinalis 3 parts, Cortex schefflerae octophyllae 10 parts.Use conventional decoction.
Clinical trial
1, choose make a definite diagnosis damp and hot and accumulate resistance type Patients with Sjogren Syndrome 54 example, meet sjogren syndrome world diagnosis (classification) standard (European standard) and " practicality traditional Chinese medical science rheumatology " dry numbness tcm diagnosis standard of revision in 2002.Meet the damp and hot clinical symptoms accumulateing resistance type sjogren syndrome simultaneously.
54 example patients are randomly divided into two groups, respectively treatment group and matched group, often organize 27 people, the age of this case of two groups, the course of disease, degrees of symptoms no significant difference, there is comparability.
2, Therapeutic Method
Treatment group takes the damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome for the treatment of prepared by embodiment 3, three times a day, 10 days courses for the treatment of.Matched group takes decoction prepared by comparative example, and every day, potion, took in three times, 10 days courses for the treatment of.Treatment through six courses for the treatment of, it is judged that therapeutic effect.
3, criterion of therapeutical effect
Recovery from illness: clinical symptoms all disappears, and every inspection is normal.
Effective: clinical symptom relief, every inspection improves or normal.
Invalid: clinical symptoms is without being clearly better or increasing the weight of.
4, therapeutic outcome
Treatment group: totally 27 example, cures 11 examples, effective 13 examples, invalid 3 examples.Total effective rate is 88.9%.
Matched group: totally 27 example, cures 8 examples, effective 12 examples, invalid 7 examples.Total effective rate is 74.1%.
From therapeutic outcome it can be seen that the present invention to treat the damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome good to the damp and hot therapeutic effect accumulateing resistance type sjogren syndrome, total effective rate has reached 88.9%, evident in efficacy.
It addition, it can be seen that the therapeutic effect for the treatment of group is substantially better than matched group from the therapeutic outcome for the treatment of group and matched group contrasts.Treatment group uses the Chinese medicine composition prepared by embodiment 3, and matched group uses the medicine soup prepared by comparative example, and comparative example compared with Example 3, without Fructus Piperis Longi, and uses conventional decoction decoction.Therefore may determine that, Fructus Piperis Longi and other medical material compatibilities, and use the preparation method of the present invention, be conducive to strengthening therapeutic effect.
Above the better embodiment of the present invention is explained in detail, but the present invention is not limited to above-mentioned embodiment, in the ken that one skilled in the relevant art is possessed, it is also possible to various changes can be made on the premise of without departing from present inventive concept.
Claims (5)
1. treat the damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome, it is characterized in that, be made up of according to the raw material of weight portion following: Radix Gentianae 8-11 part, Fructus Tritici Levis 14-17 part, Radix Trichosanthis 12-15 part, Radix Scutellariae 6-8 part, 10-14 part Radix Ophiopogonis, Cortex Magnoliae Officinalis 2-5 part, Cortex schefflerae octophyllae 9-12 part, Fructus Piperis Longi 1-3 part.
The damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome for the treatment of the most according to claim 1, it is characterized in that, be made up of according to the raw material of weight portion following: Radix Gentianae 9-10 part, Fructus Tritici Levis 15-16 part, Radix Trichosanthis 13-14 part, Radix Scutellariae 7-8 part, 11-13 part Radix Ophiopogonis, Cortex Magnoliae Officinalis 3-4 part, Cortex schefflerae octophyllae 10-11 part, Fructus Piperis Longi 1-2 part.
The damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome for the treatment of the most according to claim 2, it is characterized in that, be made up of according to the raw material of weight portion following: Radix Gentianae 9 parts, Fructus Tritici Levis 16 parts, Radix Trichosanthis 13 parts, Radix Scutellariae 7 parts, Radix Ophiopogonis 12 parts, Cortex Magnoliae Officinalis 3 parts, Cortex schefflerae octophyllae 10 parts, Fructus Piperis Longi 2 parts.
4. the preparation method treating the damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome as described in claim 1-3 is arbitrary, it is characterised in that step is as follows:
1) weigh Fructus Tritici Levis, after cleaning-drying, grind, it is thus achieved that Fructus Tritici Levis powder, standby；
2) weigh Radix Gentianae, Radix Scutellariae, Radix Ophiopogonis, Cortex Magnoliae Officinalis, Cortex schefflerae octophyllae and Fructus Piperis Longi, after cleaning, drying, pulverize, mix homogeneously, it is thus achieved that the first mixed-powder, weigh Radix Trichosanthis, Radix Trichosanthis is added to the first mixed-powder, mix homogeneously, it is thus achieved that the second mixed-powder；
3) the second mixed-powder is put into decoction container, adds the water of 10-12 times amount, decoct 2-3h, obtain a decoction liquor and medicinal residues, medicinal residues are added again the water of 6-8 times amount, decoct 1-2h, obtain secondary decoction liquor and secondary medicinal residues, secondary medicinal residues are added 80% ethanol solution of 8-10 times amount, heating and refluxing extraction 50-60min, filters, obtain reflux extracting liquid and three medicinal residues, decoction liquor, secondary decoction liquor and reflux extracting liquid are merged, filters, it is thus achieved that total medicinal liquid；
4) it is dry cream by total medicinal liquid evaporation and concentration；
5) dried cream powder is broken, add Fructus Tritici Levis powder, mix homogeneously, make tablet or capsule, the damp and hot Chinese medicine composition accumulateing resistance type sjogren syndrome must be treated.
5. the Chinese medicine composition as described in claim 1-3 is arbitrary treats the damp and hot purposes accumulate in resistance type sjogren syndrome medicine in preparation.
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