CN1363380A

CN1363380A - Medicine for treating xerosis syndrome and its preparing process

Info

Publication number: CN1363380A
Application number: CN 02109042
Authority: CN
Inventors: 王光辉
Original assignee: Individual
Current assignee: Individual
Priority date: 2002-01-15
Filing date: 2002-01-15
Publication date: 2002-08-14
Anticipated expiration: 2022-01-15
Also published as: CN1244369C

Abstract

A medicine for treating xerosis syndrome is prepared from 7 Chinese-medicinal materials including rehmannia root, forsythia fruit, cinnabar, gypsum, etc through proportioning and pulverizing by 100 meshes. Its advantages include quickly taking its effect, short course of treatment and high effective rate and cure rate.

Description

The medicine and the preparation method of treatment sjogren syndrome

Technical field: the present invention relates to a kind of medicine for the treatment of sjogren syndrome and preparation method thereof.Sjogren syndrome is a kind of to invade exocrine gland, is a kind of systemic connective tissue disease of common performance with mouth, xerophthalmia scheorma.Can be divided into two kinds of constitutional and Secondary cases, the former has the other system infringement more except that the mouth xerophthalmia scheorma, and the latter then is another kind of sure connective tissue disease coexistence, as rheumatoid arthritis, and systemic lupus erythematosus (sle).

Background technology: at present, existing do not have radical treatment to the treatment of sjogren syndrome, primary disease mainly be based on xerostomia, the eye dried, with arthralgia, myasthenia, xerosis cutis, cheilosis often involve other internal organs system, kidney, lungs and digestive system and nervous system, and cardiovascular system is had in various degree influence, xerostomia is suitably drunk water or is used artificial saliva, eye to do with corresponding remissive treatments such as artificial tears's eye drips.

Summary of the invention: in order to solve the deficiency that prior art exists, the invention provides a kind of cure rate and effective percentage height, rapid-action, medicine of the treatment sjogren syndrome that the cycle is short and preparation method thereof.

Compare with prior art, took medicine of the present invention four months to six months, recovery from illness 170 examples among the 188 routine patients, produce effects 16 examples, invalid 2 examples, the effective percentage women can reach 99.4%, and the male reaches 94.4%.

The present invention uses through clinical 188 examples, now the clinical research achievement is summarized as follows:

One, case is selected:

On inspection, except after the lymphoma, HIV infection, sarcoidosis, graft versus host disease index promptly be diagnosed as Patients with Sjogren Syndrome possessing following at least four conditions.

Two, diagnostic criteria is as follows:

1, xerostomia continues more than 3 months;

2, eye is done and is continued more than 3 months;

3, the schivmer test is positive, the filter paper wetted length: normally be 15mm/5min,＜5mm/5min is undesired certainly or have the corneal dyeing test positive: drip rose-bengal, slit lamp examination cornea, a side＞10 colored spots are undesired;

4, the lip biopsy is shown 〉=1 kitchen range lymphocytic infiltration 4mm ², allly have 〉=it is a kitchen range that 50 lymphocytes are assembled;

5, salivary flow lowers, and be attenuating without saliva stimulating flow＜0.05ml/min, or parotid gland radiography is unusual, and it is irregular to show as cheek pipe, narrow or expansion, and iodine liquid deposits terminal unusual as botryoidalis or salivary gland scintigraphy in body of gland; Show as: 1. developing time postpones: normal oral cavity radioactivity (being half-moon-shaped) time of occurrence (T _o)＜10min, the parotid gland and penetrating property (T in rush hour ₁)=20-30min, oral cavity radioactivity＞parotid gland time of launch (TOP)=40min; 2. the salivary gland radioactive uptake reduces, and is 3. reduced by the radioactive intensity of salivary gland secretion to the oral cavity;

6, the anti-SS-A or the Anti SS-B antibody positive.

Male's 18 examples in the case, year order are in 51-62 year, women's 170 examples, and year order is 40-53 year, city patient 184 examples, rural patient 4 examples.

Two, select medicine of the present invention.

Three, sjogren syndrome treatment and therapeutic effect relationship.

Sex	Case load	Recovery from illness	Produce effects	Invalid	Effective percentage	Inefficiency
Sex	Case load	Recovery from illness	Produce effects	Invalid	Effective percentage	Inefficiency	The woman	??170	??156	??13	??1	??99.4％	??0.59％
The man	??18	??14	??3	??1	??94.4％	??5.56％	The woman	??170	??156	??13	??1	??99.4％	??0.59％

Four, the treatment course of treatment of sjogren syndrome

Recovery from illness	Healing time
	Healing time			One month	Two months	Three months	Four months	Five months	Six months
	170	?41	??68	One month	Two months	Three months	Four months	Five months	Six months	??61

Five, Therapeutic Method

The patient takes medicine three every day, each 4-5 gram, and 30 days is a course of treatment.

Six, curative effect determinate standard

Recovery from illness: xerostomia, eye are done, dryness in the nasal cavity, lossless, myasthenia of limbs transference cure, and salivation and nasal cavity glandular secretion amount are normal, and appetite is normal, and urine amount and defecation are normal, and amount of drinking water is the same with the normal person, nervous transference cure uncomfortable in chest.Be negative through the lab testing rheumatoid factor, antinuclear antibody is negative, and urine PH value is normal, Anti SS-A antibody, Anti SS-B antibody are negative, and it is normal that liver transaminase recovers, and it is normal that albumin and globulin ratio are recovered, it is normal that the blood ion recovers, and gamma globulin is normal.

Produce effects: xerostomia, dryness in the nasal cavity, lossless symptom are obviously alleviated, and dried the failing of eye solves fully, and nervous uncomfortable in chest, myasthenia of limbs symptom is obviously alleviated.Diet and sleep are good, and two is just normal substantially, remove the anti-SS-A and the Anti SS-B antibody positive, and gamma globulin is high, and all the other are all normal.

Invalid: xerostomia, dryness in the nasal cavity, lossless, xerophthalmia shape do not slow and separate, and various hemogram checkings all do not have change.

Embodiment 1: a kind of medicine for the treatment of sjogren syndrome, and it is to be made by the raw material of following parts by weight:

Cinnabaris 1

The Radix Rehmanniae 1

Radix Rehmanniae Preparata 1

Fructus Forsythiae 1

Radix Platycodonis 0.5

Herba Dendrobii 0.5

Radix Codonopsis 1

Radix Notoginseng powder 0.5

Rhizoma Curcumae Longae 1

Gypsum Fibrosum 1.5

Rhizoma Coptidis 0.5

Radix Gentianae 0.5

Flos Albiziae 1.5

Radix Trichosanthis 1

Radix Angelicae Sinensis 1.5

It is 100 order powder that above-mentioned each raw material is pulverized in proportion.

Embodiment 2: a kind of medicine for the treatment of sjogren syndrome, and it is to be made by the raw material of following parts by weight:

Cinnabaris 1

The Radix Rehmanniae 2

Radix Rehmanniae Preparata 2

Fructus Forsythiae 2

Radix Platycodonis 1.5

Herba Dendrobii 1.5

Radix Codonopsis 2

Radix Notoginseng powder 1.5

Rhizoma Curcumae Longae 2

Gypsum Fibrosum 2.5

Rhizoma Coptidis 1.5

Radix Gentianae 1.5

Flos Albiziae 2.5

Radix Trichosanthis 2

Radix Angelicae Sinensis 2.5

Embodiment 3: a kind of medicine for the treatment of sjogren syndrome, and it is to be made by the raw material of following parts by weight:

Cinnabaris 1

The Radix Rehmanniae 1.5

Radix Rehmanniae Preparata 1.5

Fructus Forsythiae 1.5

Radix Platycodonis 1

Herba Dendrobii 1

Radix Codonopsis 1.5

Radix Notoginseng powder 1

Rhizoma Curcumae Longae 1.5

Gypsum Fibrosum 2

Rhizoma Coptidis 1

Radix Gentianae 1

Flos Albiziae 2

Radix Trichosanthis 1.5

Radix Angelicae Sinensis 2

Claims

1, a kind of medicine for the treatment of sjogren syndrome is characterized in that it is to be made by the raw material of following parts by weight:

Cinnabaris 1

Radix Rehmanniae 1-2

Radix Rehmanniae Preparata 1-2

Fructus Forsythiae 1-2

Radix Platycodonis 0.5-1.5

Herba Dendrobii 0.5-1.5

Radix Codonopsis 1-2

Radix Notoginseng powder 0.5-1.5

Rhizoma Curcumae Longae 1-2

Gypsum Fibrosum 1.5-2.5

Rhizoma Coptidis 0.5-1.5

Radix Gentianae 0.5-1.5

Flos Albiziae 1.5-2.5

Radix Trichosanthis 1-2

Radix Angelicae Sinensis 1.5-2.5

2, a kind of manufacture method of making the medicine of the described treatment sjogren syndrome of claim 1 is characterized in that: it is 100 order powder that above-mentioned each raw material is pulverized in proportion.