CN1180775C - Compound stomatocase-treating capsule - Google Patents
Compound stomatocase-treating capsule Download PDFInfo
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- CN1180775C CN1180775C CNB021256829A CN02125682A CN1180775C CN 1180775 C CN1180775 C CN 1180775C CN B021256829 A CNB021256829 A CN B021256829A CN 02125682 A CN02125682 A CN 02125682A CN 1180775 C CN1180775 C CN 1180775C
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Abstract
The present invention relates to a compound stomatocase-treating capsule which belongs to the technical field of medicine. The capsule is composed of 11.6 to 232 mg of cimetidine, 11.6 to 232 mg of metronidazole, 0.3 to 6 mg of metoclopramide, 0.3 to 6 mg of prednisone, 0.23 to 4.6 mg of VB1(vitamin B1), 0.105 to 2.1 mg of VB2 (vitamin B2), 0.015 to 0.3 mg of VB 6 (vitamin B6), 0.78 to 15.6 mg of niacinamide and 0.07 to 1.4 mg of dextrorotation calcium pantothenate. The capsule of the present invention has the advantages of broad preparing raw material source, cheapness, no special abnormal taste or stimulation when orally taken, and good mouth feel and reduces medicine cost. The present invention is used by 3000 clinic acute and chronic recurrent oral ulcer patients to prove that the total effective rate reaches 100%, and no specific toxic or side reaction occurs.
Description
Technical field
The invention belongs to medical technical field, particularly a kind of compound stomatocase-treating capsule.
Background technology
Method to the oral cavity ulcer treatment is " Oral Science " used according to the undergraduate course five-year system clinical medicine system that Mao Zuyi edits at present.Divide local and the treatment of whole body two aspects.
One, topical therapeutic:
1. Chinese powder medicine, as nourishing yin shengjisan, XILEI SAN, the ice friend looses and waits that the part is deposited spreads.
2. oral ulcer medicine film, one for several times, with reference to calendar year 2001 December " Arzneibucs " published.
3. isolated ulcer also usable concentration is that 10wt% silver nitrate or 5wt% trichloroacetic acid etc. burn.
4. huge ulcer can be pressed the ulcer size with hydrocortisone acetate or the imperial suspension of powerful pine, be taken the circumstances into consideration infiltration injecting connective tissue under ulcer.
Two, whole body therapeutic:
1. Chinese traditional treatment:
Excess fire type: suitable clearing away heat-fire, removing heat from blood relieving constipation or heat-clearing and toxic substances removing, plus-minuss such as Liangge San, yun YINQIAO are selected in the removing heat from blood eliminating dampness by diuresis for use;
Asthenic fire type: should nourishing YIN and clearing away heat, suppressing the hyperactive liver nourishes blood or invigorating the spleen and regulating the stomach, QI invigorating dampness removing, can select LIUWEI DIHUANG WAN for use, the BUZHONG YIQI TANG plus-minus.
2. western medical treatment: the solid ferment medicine usefulness of classes such as prednisone, dexamethasone, take the circumstances into consideration to select for use immunosuppressant, as azathioprine, cyclophosphamide (side effect etc. is arranged); Select immunostimulant for use, transfer factor, gamma globulin etc.
By clinical observation, find that there is following several respects deficiency in this therapeutic scheme:
1. in theory this sick cause of disease, pathogenesis, pathological change are not still had unified understanding, make the therapeutic scheme target indeterminate, lack specificity.
2. mainly based on to the ill, cure the symptoms, not the disease in the western medicine aspect, and medicament selection is simple, no particularity, the therapeutic effect pain relieving is poor, and ulcer is difficult for healing or the easily recurrence of temporary transient healing back, and there is serious toxic and side effects in the part medicine, for human body causes unnecessary harm.
3. Chinese traditional treatment: be that to control with dialectical opinion be principle, a people one side, vary with each individual that dialectical error is arranged slightly, cause that easily the state of an illness increases the weight of, must under the professional instructs, use, and the preparation complexity, take, carry inconvenience, curative effect is difficult to determine.
4. the local medicine that uses has the abnormal flavour zest strong, and for the patient brings the suffering of illness that is difficult to accept, topical remedy is once elimination, and the state of an illness may be shown effect once more, does not reach the radical cure purpose.
Summary of the invention
The objective of the invention is provides a kind of compound stomatocase-treating capsule at existing deficiency in the oral ulcer treatment.
The inventor in conjunction with modern physiology, pathology, pharmacology, immunology progress, proposes the understanding of following several respects through clinical observation over 10 years to the oral cavity ulcer treatment:
1. in theory the cause of disease, pathogenesis aspect are thought when being mainly the shortage of trace element in the low and/or body of immune function of human body, and/or in the presence of extraneous factor (pH value reduction etc. in as hyperpyrexia antibacterial, viral infection, wound, burn, oral cavity), make oral mucosa lesion, being difficult in time, healing develops into ulcer, select western medicine at Therapeutic Principle's directiveness that the cause of disease, pathogenesis propose to control by Chinese medicine organic conception and dialectical opinion, thereby form with instruction of Chinese Medicine theory the method for western medicine.
2. selecting medicine is to strengthen immune function of human body, replenish the trace element that health is lacked, grow, promote that for mucosa ulcer healing provides the condition of general material, improve edema, allergy, the antibacterial of killing ulcer spot, virus that the ulcer part causes because of inflammation simultaneously, improve the stimulation of oral cavity inner acidic environment, thereby for ulcer healing provides good local environment, both organically combine, and make the timely pain relieving of ulcer, rapidly healing, and can make ulcer be difficult for recurrence, reach treating both the principal and secondary aspects of a disease.
3. selected medicine is all with reference to calendar year 2001 December " the practical Arzneibucs " published, through drug combination be selected drug dose all less than positive usual amounts, make the toxic and side effects of every kind of medicine be reduced to floor level, the infringement of avoiding medicine that human body is caused.
The composition of compound stomatocase-treating capsule of the present invention and content are:
Cimetidine 11.6-232mg metronidazole 11.6-232mg
Metoclopramide 0.3-6mg prednisone 0.3-6mg
VB
1(vitamin B
1) 0.23-4.6mg VB
2(vitamin B
2) 0.105-2.1mg
VB
6(vitamin B
6) 0.015-0.3mg nicotiamide 0.78-15.6mg
Dextro calcium pantothenate 0.07-1.4mg
With above nine kinds of medicines mix homogeneously after grinding, in incapsulating then, promptly prepare compound stomatocase-treating capsule of the present invention.
The preferred composition and the content of every compound stomatocase-treating capsule of the present invention are:
Cimetidine 58mg metronidazole 58mg
Metoclopramide 1.5mg prednisone 1.5mg
VB
1(vitamin B
1) 1.15mg VB
2(vitamin B
2) 0.525mg
VB
6(vitamin B
6) 0.075mg nicotiamide 3.9mg
Dextro calcium pantothenate 0.35mg
The characteristics of compound stomatocase-treating capsule of the present invention:
1. use through clinical 3000 routine acute and chronics, recurrent oral ulceration patient, healing time is the shortest 24 hours, and is the longest 10 days.Take dose: with the each 500mg of adult's (referring to more than 14 years old), twice of every day.Children's's (0-14 year) is oral at twice with per kilogram of body weight 20-25mg every day.With per 5 days be a course of treatment, 3,000 patients use, one of them course of treatment healing person be 93%, two the course of treatment healing person be 6.2%, three the course of treatment healing person be 0.8%; Total effective rate reaches 100%, does not see special toxicity, oral no specific peculiar smell and zest, good mouthfeel.
2. preparation raw material wide material sources, cheapness, cost of drugs is reduced.
3. the patient is easy to use, can be own according to the symptom of feeling, and age, body weight are pressed the medicine explanation and are selected medication, need not the professional instruct.
4. dosage form is a capsule-type, and is oral, easy to carry, is not subjected to condition restriction.
Compound stomatocase-treating capsule of the present invention improves whole body and oral cavity partial environment with human body immunity improving power, is used for the treatment of acute and chronic, recurrent oral ulceration and the double periodontitis of controlling, ulcerative colitis.Every capsules content of dispersion is 125mg.When using compound stomatocase-treating capsule of the present invention, should notice that (1) tuberculosis, diabetes, anemia of pregnant woman can take the circumstances into consideration decrement; (2) chickenpox, the careful usefulness of herpes zoster patient; (3) period in a medicine fasting raw food zest, sugar and the big diet of sugar content are based on light.
The specific embodiment
Embodiment 1:
Zheng * *, man, 47 years old, recurrent oral ulceration 10 years is surplus, annual outbreak several, it is surplus that each outbreak continues January, and fluid infusion support once is anti-to be felt, western medicine and treatment by Chinese herbs, poor effect, going to a doctor in this morbidity back on the 10th day, checks and see lingual frenum, the both sides mucosa respectively has the round ulcer of a diameter 3mm, the inboard mucosa of lower lip has the oval ulcer of diameter 4mm size, and is congested on every side, edema, local pain is through taking compound stomatocase-treating capsule of the present invention, press 500mg/ time (promptly 4), 2 times/day, pain relief after 12 hours, ulcer surface dwindles, the ulcer surface healing is followed up a case by regular visits to and was not seen recurrence in 1 year after 36 hours.
The component of compound stomatocase-treating capsule and content are:
Cimetidine 58mg metronidazole 58mg metoclopramide 1.5mg
Prednisone 1.5mg VB
11.15mg VB
20.525mg
VB
60.075mg nicotiamide 3.9mg dextro calcium pantothenate 0.35mg
With above nine kinds of medicines mix homogeneously after grinding, in incapsulating then, promptly prepare compound stomatocase-treating capsule of the present invention, every capsules content of dispersion is 125mg.
Embodiment 2:
Poplar * *, the woman, 30 years old, recurrent oral ulceration 10 years was surplus, whenever fever, lose eye, fatigue promptly shows effect, sky surplus each outbreak 20, once western medicines in treatment was invalid, went to a doctor in this morbidity back on the 7th day, checked that mouthful inboard mucosa of disgrace has the big aphtha of a diameter 6mm as follows, cheek inboard mucosa in a left side has the big aphtha of a diameter 4mm, congested on every side, local pain, ulcer surface has the yellow-white pseudomembrane, through taking compound stomatocase-treating capsule of the present invention, 500mg/ time, 2 times/day, pain relieving in 6 hours, ulcer surface dwindled in 12 hours, ulcer healing after 30 hours serve on 5 days transference cures.
The component of compound stomatocase-treating capsule and content are:
Cimetidine 58mg metronidazole 58mg metoclopramide 1.5mg
Prednisone 1.5mg VB
11.15mg VB
20.525mg
VB
60.075mg nicotiamide 3.9mg dextro calcium pantothenate 0.35mg
With above nine kinds of medicines mix homogeneously after grinding, in incapsulating then, promptly prepare compound stomatocase-treating capsule of the present invention, every capsules content of dispersion is 125mg.
Embodiment 3:
Zheng *, the woman, 4 months, body weight 6Kg, to refuse the breast prescription on individual diagnosis in more than two days of crying and screaming, the temperature of having a medical check-up is T37.20 ℃.Mind is clear, spirit is poor, it is normal to grow, reddened and swollen lips, and the saliva amount is many, and 3 of the big aphthas of the grain of rice are arranged in the last lip, and the tip of the tongue and lingual frenum root have 1 * 1mm
23 of big aphthas, blush, swelling on every side, oral VB
2It is invalid that local use ice friend looses, and gives the clothes compound stomatocase-treating capsule, measures with per kilogram 25mg every day and calculate, and divides secondary to take, and crying and screaming after 3 hours stops, feed, and the minimizing of saliva amount, oral cavity ulcer healing after 24 hours serve on recovery from illness on the two.
The component of compound stomatocase-treating capsule and content are:
Cimetidine 17mg metronidazole 83mg metoclopramide 3.1mg
Prednisone 5mg VB
14.0mg VB
22.014mg
VB
60.086mg nicotiamide 12.8mg dextro calcium pantothenate 1mg
With above nine kinds of medicines mix homogeneously after grinding, in incapsulating then, promptly prepare compound stomatocase-treating capsule of the present invention, every capsules content of dispersion is 125mg.
Embodiment 4:
Guo * *, the man, 12 years old, body weight 30Kg went to a doctor with glossodynia, feed difficulty in 5 days, checked and saw that respectively there is 2 * 2mm the tongue body both sides
2Big aphtha, blush slightly on every side, the lip of the tongue has blurred big or small 2 place's ulcer, intramuscular injection pioneer five, oral B
2Cydiodine, poor effect and going to a doctor.Give the clothes compound stomatocase-treating capsule, calculate (promptly 6 are divided each three of secondary) with per kilogram 25mg every day amount.Take pain relief in back 12 hours.Ulcer healing after 36 hours serve on recovery from illness on the three.
The component of compound stomatocase-treating capsule and content are:
Cimetidine 11mg metronidazole 58mg metoclopramide 6mg
Prednisone 0.3mg VB
10.3mg VB
22.1mg
VB
60.25mg nicotiamide 13.6mg dextro calcium pantothenate 0.1mg
With above nine kinds of medicines mix homogeneously after grinding, in incapsulating then, promptly prepare compound stomatocase-treating capsule of the present invention, every capsules content of dispersion is 125mg.
Embodiment 5:
Pueraria lobota * *, the man, 92 years old, with oral cavity pain, take food a difficult week, through fluid infusion, use KOUQIANG KUIYANG MO, oral Wu too stomatocase-treating capsule treats the commentaries on classics prescription on individual diagnosis of not getting better.Check, see that respectively there is 2 * 2mm the tongue both sides
2Big aphtha, surperficial HUANGBAI(sic), there is 3 * 3mm red slightly on every side right cheek inboard
2Big aphtha is given the clothes compound stomatocase-treating capsule, and 500mg/ time, every day 2 times, pain relief can be taken food after 24 hours, and ulcer was dwindled in 48 hours, serve on recovery from illness in 5 days.Follow up a case by regular visits to and do not see recurrence in 1 year.
The component of compound stomatocase-treating capsule and content are:
Cimetidine 230mg metronidazole 200mg metoclopramide 6mg
Prednisone 5mg VB
1N 0.2mg VB
20.105mg
VB
60.3mg nicotiamide 15mg dextro calcium pantothenate 1.4mg
With above nine kinds of medicines mix homogeneously after grinding, in incapsulating then, promptly prepare compound stomatocase-treating capsule of the present invention, every capsules content of dispersion is 125mg.
Claims (2)
1. compound stomatocase-treating capsule is characterized in that: following nine kinds of medicines after grinding, by its content mix homogeneously, in incapsulating then, are promptly prepared compound stomatocase-treating capsule,
Cimetidine 11.6-232mg metronidazole 11.6-232mg
Metoclopramide 0.3-6mg prednisone 0.3-6mg
VB
1 0.23-4.6mg VB
2 0.105-2.1mg
VB
60.015-0.3mg nicotiamide 0.78-15.6mg
Dextro calcium pantothenate 0.07-1.4mg.
2. capsule as claimed in claim 1 is characterized in that: the composition of described compound stomatocase-treating capsule and content are:
Cimetidine 58mg metronidazole 58mg
Metoclopramide 1.5mg prednisone 1.5mg
VB
1 1.15mg VB
2 0.525mg
VB
60.075mg nicotiamide 3.9mg
Dextro calcium pantothenate 0.35mg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021256829A CN1180775C (en) | 2002-07-29 | 2002-07-29 | Compound stomatocase-treating capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021256829A CN1180775C (en) | 2002-07-29 | 2002-07-29 | Compound stomatocase-treating capsule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1387852A CN1387852A (en) | 2003-01-01 |
| CN1180775C true CN1180775C (en) | 2004-12-22 |
Family
ID=4745633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021256829A Expired - Fee Related CN1180775C (en) | 2002-07-29 | 2002-07-29 | Compound stomatocase-treating capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1180775C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105287561A (en) * | 2015-11-25 | 2016-02-03 | 上海交通大学医学院附属瑞金医院 | Pharmaceutical composition for treating ulcerative colitis |
-
2002
- 2002-07-29 CN CNB021256829A patent/CN1180775C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1387852A (en) | 2003-01-01 |
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