CN105899242B - 包含聚合抑制剂的一组分纤维蛋白胶 - Google Patents

包含聚合抑制剂的一组分纤维蛋白胶 Download PDF

Info

Publication number
CN105899242B
CN105899242B CN201480071021.0A CN201480071021A CN105899242B CN 105899242 B CN105899242 B CN 105899242B CN 201480071021 A CN201480071021 A CN 201480071021A CN 105899242 B CN105899242 B CN 105899242B
Authority
CN
China
Prior art keywords
formulation
fibrin
gprp
peptide
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201480071021.0A
Other languages
English (en)
Chinese (zh)
Other versions
CN105899242A (zh
Inventor
Y.皮尔佩
A.迪安格里斯
Y.泽德夫
S.多龙
I.努尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omrix Biopharmaceuticals Ltd
Ethicon Inc
Original Assignee
Omrix Biopharmaceuticals Ltd
Ethicon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omrix Biopharmaceuticals Ltd, Ethicon Inc filed Critical Omrix Biopharmaceuticals Ltd
Publication of CN105899242A publication Critical patent/CN105899242A/zh
Application granted granted Critical
Publication of CN105899242B publication Critical patent/CN105899242B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/108—Specific proteins or polypeptides not covered by groups A61L24/102 - A61L24/106
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/25—Peptides having up to 20 amino acids in a defined sequence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A61L2300/254—Enzymes, proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/432—Inhibitors, antagonists
    • A61L2300/434—Inhibitors, antagonists of enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
CN201480071021.0A 2013-12-24 2014-12-04 包含聚合抑制剂的一组分纤维蛋白胶 Expired - Fee Related CN105899242B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361920646P 2013-12-24 2013-12-24
US61/920646 2013-12-24
IL230151A IL230151A0 (en) 2013-12-24 2013-12-24 One-component fibrin glue containing a polymerization inhibitor
IL230151 2013-12-24
PCT/IL2014/000063 WO2015097688A1 (en) 2013-12-24 2014-12-04 One component fibrin glue comprising a polymerization inhibitor

Publications (2)

Publication Number Publication Date
CN105899242A CN105899242A (zh) 2016-08-24
CN105899242B true CN105899242B (zh) 2020-01-14

Family

ID=51691232

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480071021.0A Expired - Fee Related CN105899242B (zh) 2013-12-24 2014-12-04 包含聚合抑制剂的一组分纤维蛋白胶

Country Status (10)

Country Link
US (2) US9814799B2 (enExample)
EP (1) EP3086818B1 (enExample)
JP (1) JP6588019B2 (enExample)
CN (1) CN105899242B (enExample)
AU (1) AU2014372152A1 (enExample)
BR (1) BR112016014870B1 (enExample)
CA (1) CA2934420A1 (enExample)
ES (1) ES2702657T3 (enExample)
IL (2) IL230151A0 (enExample)
WO (1) WO2015097688A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL230151A0 (en) 2013-12-24 2014-09-30 Omrix Biopharmaceuticals Ltd One-component fibrin glue containing a polymerization inhibitor
IL231792A0 (en) 2014-03-27 2014-08-31 Omrix Biopharmaceuticals Ltd Device and method for the preparation and administration of one-component fibrin glue
WO2019007469A1 (en) * 2017-07-07 2019-01-10 Vivostat A/S TISSUE SEALING AGENT FOR USE IN FORMATION OF ANASTOMOSIS IN THE GASTROINTESTINAL TRACT
CN110669126B (zh) * 2019-10-23 2022-08-16 广州领晟医疗科技有限公司 多肽gpr5及其促进肝细胞增殖和抑制肝细胞凋亡的用途
CN111499687A (zh) * 2020-03-13 2020-08-07 宁波市第一医院 1-磷酸鞘氨醇受体3激动剂及其制备方法和应用
CN113929741A (zh) * 2020-06-29 2022-01-14 首都医科大学 华法林-4-O-乙酰-Gly-Pro-Arg-Pro-AA1及其合成、活性和应用
CN113929742A (zh) * 2020-06-29 2022-01-14 首都医科大学 华法林-4-O-乙酰-Gly-Pro-Arg-Pro-AA2及其合成,活性和应用
CN113929736B (zh) * 2020-06-29 2024-01-26 首都医科大学 Gly-Pro-Arg-Pro-氧乙氨羰基华法林,其合成,活性和应用
CN113929739B (zh) * 2020-06-29 2023-07-28 首都医科大学 Gly-Pro-Arg-Pro-NH乙氧羰华法林,其合成,活性和应用
EP4262884A1 (en) 2020-12-21 2023-10-25 Ethicon, Inc Bleeding detection method
CN113967286B (zh) * 2021-11-03 2022-10-21 吉林大学 一种短肽干粉粘合剂在缺损硬膜的封堵与修复中的应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0592242A1 (en) * 1992-10-08 1994-04-13 E.R. Squibb & Sons, Inc. Fibrin sealant compositions and method for utilizing same
WO1998020931A1 (en) * 1996-11-15 1998-05-22 Bristol-Myers Squibb Company Devices and methods for applying a mixture of two or more liquid components to form a biomaterial
US5985315A (en) * 1996-12-30 1999-11-16 Inoteb Method of preparing a biological glue able to coagulate simply by addition of calcium ions
CN101687061A (zh) * 2006-11-27 2010-03-31 哈莫斯塔蒂斯有限公司 生物凝胶
CN102307600A (zh) * 2008-12-11 2012-01-04 巴克斯特国际公司 以纤维蛋白原和硫酸化多糖为基础的制剂

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT366916B (de) 1980-04-02 1982-05-25 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen
US4627879A (en) 1984-09-07 1986-12-09 The Trustees Of Columbia University In The City Of New York Fibrin adhesive prepared as a concentrate from single donor fresh frozen plasma
DE3622642A1 (de) 1986-07-05 1988-01-14 Behringwerke Ag Einkomponenten-gewebekleber sowie verfahren zu seiner herstellung
US4978336A (en) 1987-09-29 1990-12-18 Hemaedics, Inc. Biological syringe system
US4874368A (en) 1988-07-25 1989-10-17 Micromedics, Inc. Fibrin glue delivery system
DE3843126C3 (de) 1988-12-22 1994-10-06 Octapharma Ag Verfahren zur Herstellung eines hochreinen Thrombinkonzentrates
US5104375A (en) 1989-10-16 1992-04-14 Johnson & Johnson Medical, Inc. Locking holder for a pair of syringes and method of use
US5219328A (en) * 1990-01-03 1993-06-15 Cryolife, Inc. Fibrin sealant delivery method
US5318524A (en) 1990-01-03 1994-06-07 Cryolife, Inc. Fibrin sealant delivery kit
DE4014655A1 (de) 1990-05-08 1991-11-14 Behringwerke Ag Peptidamide, verfahren zu deren herstellung und diese enthaltende mittel als fibrin/thrombin-gerinnungsinhibitoren
US5792835A (en) 1991-09-05 1998-08-11 Baxter International Inc. Method of preparing a topical fibrinogen complex
WO1993005822A1 (en) 1991-09-27 1993-04-01 Octapharma Ag Tissue glue prepared by using cryoprecipitate
US5831005A (en) 1992-09-24 1998-11-03 Chiron Corporation Synthesis of N-substituted oligomers
US5877278A (en) 1992-09-24 1999-03-02 Chiron Corporation Synthesis of N-substituted oligomers
US5723579A (en) 1996-02-02 1998-03-03 Bayer Corporation Fibrinogen binding peptides
WO1997029792A1 (en) 1996-02-20 1997-08-21 Cohesion Corporation Tissue sealant compositions and methods of use thereof
DE19636622C1 (de) 1996-09-10 1998-06-10 Omrix Biopharm Sa Auftragvorrichtung zum Auftragen eines Mehrkomponenten-Gewebeklebstoffs und Halterung für eine solche Auftragvorrichtung
US5844087A (en) 1996-11-05 1998-12-01 Bayer Corporation Method and device for delivering fibrin glue
US6613020B1 (en) 1996-12-06 2003-09-02 Bristol-Myers Squibb Company Method of applying a mixture of two liquid components as well as a device for carrying out the method
EP0856317A1 (en) 1997-01-31 1998-08-05 Omrix Biopharmaceuticals S.A. A stabilized mixture comprising fibrinogen
US6121232A (en) 1997-01-31 2000-09-19 Omrix Biopharmaceuticals Sa Stabilized mixture comprising fibrinogen
US6783514B2 (en) 1997-01-31 2004-08-31 United States Surgical Corporation Fibrin sealant applicator
GB9711927D0 (en) 1997-06-09 1997-08-06 Bristol Myers Squibb Co Compositions useful as fibrin sealants
PL205685B1 (pl) 2001-05-21 2010-05-31 Omrix Biopharm Sa Sposób in vitro usuwania lub wyodrębniania plazminogenu lub plazminy w obecności fibrynogenu, stałe podłoże powinowactwa do oczyszczania mieszaniny zawierającej fibrynogen i plazminę i/lub plazminogen oraz krioprecypitat
US6908899B2 (en) 2001-08-17 2005-06-21 U.S. Dept. Of Veterans Affairs Pro-inflammatory fibrinopeptide
JP2005508925A (ja) * 2001-10-03 2005-04-07 クリストファー ジェイ ウールヴァートン 貯蔵安定なフィブリノーゲン溶液
DE10261126A1 (de) * 2002-08-13 2004-03-04 Aventis Behring Gmbh Lagerungsstabile, flüssige Fibrinogen-Formulierung
US7208087B2 (en) 2005-02-15 2007-04-24 Bio-Rad Laboratories, Inc. Dual-chamber chromatographic cartridge
DE602005013301D1 (de) 2005-11-22 2009-04-23 Omrix Biopharm Sa Applikatorvorrichtung zum aufbringen einer mehrkomponenten-flüssigkeit
FR2894831B1 (fr) 2005-12-16 2008-02-15 Lab Francais Du Fractionnement Colle biologique exempte de thrombine et son utilisation comme medicament.
FR2909180B1 (fr) * 2006-11-29 2009-02-20 Diagnostica Stago Soc Par Acti Methode de mesure fonctionnelle de l'activite de la thrombomoduline plasmatique.
US8367802B2 (en) 2009-06-18 2013-02-05 Biomedica Management Corporation Method to produce fibrin monomer in acid media for use as tissue sealant
WO2011006069A1 (en) 2009-07-09 2011-01-13 Georgia Tech Research Corporation Peptides for binding fibrinogen and fibrin
IL230151A0 (en) 2013-12-24 2014-09-30 Omrix Biopharmaceuticals Ltd One-component fibrin glue containing a polymerization inhibitor
IL230150A0 (en) 2013-12-24 2014-09-30 Omrix Biopharmaceuticals Ltd One-component fibrin glue containing zymogens
IL231792A0 (en) * 2014-03-27 2014-08-31 Omrix Biopharmaceuticals Ltd Device and method for the preparation and administration of one-component fibrin glue

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0592242A1 (en) * 1992-10-08 1994-04-13 E.R. Squibb & Sons, Inc. Fibrin sealant compositions and method for utilizing same
CN1091315A (zh) * 1992-10-08 1994-08-31 E·R·斯奎布父子公司 血纤维蛋白封闭剂组合物及其使用方法
WO1998020931A1 (en) * 1996-11-15 1998-05-22 Bristol-Myers Squibb Company Devices and methods for applying a mixture of two or more liquid components to form a biomaterial
US5985315A (en) * 1996-12-30 1999-11-16 Inoteb Method of preparing a biological glue able to coagulate simply by addition of calcium ions
CN101687061A (zh) * 2006-11-27 2010-03-31 哈莫斯塔蒂斯有限公司 生物凝胶
CN102307600A (zh) * 2008-12-11 2012-01-04 巴克斯特国际公司 以纤维蛋白原和硫酸化多糖为基础的制剂

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Engineering fibrin polymers through engagement of alternative polymerization mechanisms;Sarah E. Stabenfeldt, Merek Gourley, Laxminarayanan Krishnan,etc;《Biomateirals》;20111021(第33期);536页左栏第3段 *

Also Published As

Publication number Publication date
US10357589B2 (en) 2019-07-23
JP2017502045A (ja) 2017-01-19
US20150174289A1 (en) 2015-06-25
BR112016014870B1 (pt) 2021-02-02
AU2014372152A1 (en) 2016-06-30
HK1231418A1 (en) 2017-12-22
JP6588019B2 (ja) 2019-10-09
IL246174B (en) 2020-08-31
ES2702657T3 (es) 2019-03-04
IL230151A0 (en) 2014-09-30
WO2015097688A1 (en) 2015-07-02
EP3086818A1 (en) 2016-11-02
IL246174A0 (en) 2016-07-31
WO2015097688A8 (en) 2016-09-15
CA2934420A1 (en) 2015-07-02
US9814799B2 (en) 2017-11-14
BR112016014870A2 (pt) 2017-09-19
CN105899242A (zh) 2016-08-24
US20180000982A1 (en) 2018-01-04
EP3086818B1 (en) 2018-10-31

Similar Documents

Publication Publication Date Title
CN105899242B (zh) 包含聚合抑制剂的一组分纤维蛋白胶
JP7146712B2 (ja) チモーゲンを含む一成分フィブリン糊
AU2003234743B2 (en) Storage-stable, liquid fibrinogen formulation
EP2130549B1 (en) Solid fibrinogen preparation
JP6717747B2 (ja) フィブリノゲン結合ペプチドを含むペプチドデンドリマー
US20060148698A1 (en) Storage-stable fibrinogen solutions
US20030091559A1 (en) Storage-stable human fibrinogen solutions
US20070014780A1 (en) Storage-stable human fibrinogen solutions
HK1231418B (en) One component fibrin glue comprising a polymerization inhibitor

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20200114

Termination date: 20211204