BR112016014870A2 - Formulação de selante líquido compreendendo monômeros de fibrina e um peptídeo de gprp, seu método de fabricação, recipiente e kit - Google Patents

Formulação de selante líquido compreendendo monômeros de fibrina e um peptídeo de gprp, seu método de fabricação, recipiente e kit

Info

Publication number
BR112016014870A2
BR112016014870A2 BR112016014870A BR112016014870A BR112016014870A2 BR 112016014870 A2 BR112016014870 A2 BR 112016014870A2 BR 112016014870 A BR112016014870 A BR 112016014870A BR 112016014870 A BR112016014870 A BR 112016014870A BR 112016014870 A2 BR112016014870 A2 BR 112016014870A2
Authority
BR
Brazil
Prior art keywords
kit
container
liquid sealant
manufacturing
formulation
Prior art date
Application number
BR112016014870A
Other languages
English (en)
Other versions
BR112016014870B1 (pt
Inventor
Pilpel Yair
Deanglis Ashley
Zherdev Yuri
Doron Sivan
Nur Israel
Original Assignee
Omrix Biopharmaceuticals Ltd
Ethicon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omrix Biopharmaceuticals Ltd, Ethicon Inc filed Critical Omrix Biopharmaceuticals Ltd
Publication of BR112016014870A2 publication Critical patent/BR112016014870A2/pt
Publication of BR112016014870B1 publication Critical patent/BR112016014870B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/108—Specific proteins or polypeptides not covered by groups A61L24/102 - A61L24/106
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/25—Peptides having up to 20 amino acids in a defined sequence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A61L2300/254—Enzymes, proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/432—Inhibitors, antagonists
    • A61L2300/434—Inhibitors, antagonists of enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions

Abstract

Formulação de selante líquido compreendendo monômeros de fibrina e um peptídeo de GPRP, seu método de fabricação, recipiente e kit. A presente invenção refere-se a formulações de selante líquido estáveis que compreendem monômeros de fibrina e um agente de bloqueio de polimerização de fibrina reversível, métodos de preparo e uso das formulações.
BR112016014870-3A 2013-12-24 2014-12-04 formulação de selante líquido compreendendo monômeros de fibrina e um peptídeo de gprp, seu método de fabricação, recipiente e kit BR112016014870B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361920646P 2013-12-24 2013-12-24
IL230151A IL230151A0 (en) 2013-12-24 2013-12-24 One-component fibrin glue containing a polymerization inhibitor
IL230151 2013-12-24
US61/920,646 2013-12-24
PCT/IL2014/000063 WO2015097688A1 (en) 2013-12-24 2014-12-04 One component fibrin glue comprising a polymerization inhibitor

Publications (2)

Publication Number Publication Date
BR112016014870A2 true BR112016014870A2 (pt) 2017-09-19
BR112016014870B1 BR112016014870B1 (pt) 2021-02-02

Family

ID=51691232

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016014870-3A BR112016014870B1 (pt) 2013-12-24 2014-12-04 formulação de selante líquido compreendendo monômeros de fibrina e um peptídeo de gprp, seu método de fabricação, recipiente e kit

Country Status (11)

Country Link
US (2) US9814799B2 (pt)
EP (1) EP3086818B1 (pt)
JP (1) JP6588019B2 (pt)
CN (1) CN105899242B (pt)
AU (1) AU2014372152A1 (pt)
BR (1) BR112016014870B1 (pt)
CA (1) CA2934420A1 (pt)
ES (1) ES2702657T3 (pt)
HK (1) HK1231418A1 (pt)
IL (2) IL230151A0 (pt)
WO (1) WO2015097688A1 (pt)

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IL230151A0 (en) 2013-12-24 2014-09-30 Omrix Biopharmaceuticals Ltd One-component fibrin glue containing a polymerization inhibitor
IL231792A0 (en) * 2014-03-27 2014-08-31 Omrix Biopharmaceuticals Ltd Device and method for the preparation and administration of one-component fibrin glue
WO2019007469A1 (en) * 2017-07-07 2019-01-10 Vivostat A/S TISSUE SEALING AGENT FOR USE IN FORMATION OF ANASTOMOSIS IN THE GASTROINTESTINAL TRACT
CN110669126B (zh) * 2019-10-23 2022-08-16 广州领晟医疗科技有限公司 多肽gpr5及其促进肝细胞增殖和抑制肝细胞凋亡的用途
CN111499687A (zh) * 2020-03-13 2020-08-07 宁波市第一医院 1-磷酸鞘氨醇受体3激动剂及其制备方法和应用
CN113929739B (zh) * 2020-06-29 2023-07-28 首都医科大学 Gly-Pro-Arg-Pro-NH乙氧羰华法林,其合成,活性和应用
CN113929742A (zh) * 2020-06-29 2022-01-14 首都医科大学 华法林-4-O-乙酰-Gly-Pro-Arg-Pro-AA2及其合成,活性和应用
CN113929736B (zh) * 2020-06-29 2024-01-26 首都医科大学 Gly-Pro-Arg-Pro-氧乙氨羰基华法林,其合成,活性和应用
CN113929741A (zh) * 2020-06-29 2022-01-14 首都医科大学 华法林-4-O-乙酰-Gly-Pro-Arg-Pro-AA1及其合成、活性和应用
US20220193272A1 (en) 2020-12-21 2022-06-23 Ethicon, Inc. Bleeding Detection Method
CN113967286B (zh) * 2021-11-03 2022-10-21 吉林大学 一种短肽干粉粘合剂在缺损硬膜的封堵与修复中的应用

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Also Published As

Publication number Publication date
ES2702657T3 (es) 2019-03-04
US10357589B2 (en) 2019-07-23
JP2017502045A (ja) 2017-01-19
CN105899242B (zh) 2020-01-14
EP3086818A1 (en) 2016-11-02
US9814799B2 (en) 2017-11-14
CA2934420A1 (en) 2015-07-02
IL246174B (en) 2020-08-31
IL246174A0 (en) 2016-07-31
EP3086818B1 (en) 2018-10-31
IL230151A0 (en) 2014-09-30
HK1231418A1 (zh) 2017-12-22
CN105899242A (zh) 2016-08-24
US20150174289A1 (en) 2015-06-25
AU2014372152A1 (en) 2016-06-30
WO2015097688A8 (en) 2016-09-15
US20180000982A1 (en) 2018-01-04
WO2015097688A1 (en) 2015-07-02
BR112016014870B1 (pt) 2021-02-02
JP6588019B2 (ja) 2019-10-09

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Legal Events

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B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B09X Republication of the decision to grant [chapter 9.1.3 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 04/12/2014, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

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B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2699 DE 27-09-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.