CN105884904B - 噬菌体衍生的抗微生物活性剂 - Google Patents

噬菌体衍生的抗微生物活性剂 Download PDF

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Publication number
CN105884904B
CN105884904B CN201610182492.XA CN201610182492A CN105884904B CN 105884904 B CN105884904 B CN 105884904B CN 201610182492 A CN201610182492 A CN 201610182492A CN 105884904 B CN105884904 B CN 105884904B
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polypeptide
protein
cell
bacterial
phage
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Expired - Fee Related
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English (en)
Chinese (zh)
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CN105884904A (zh
Inventor
S·帕德马纳巴恩
V·D·保罗
R·S·萨拉瓦纳
B·斯里拉姆
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Berkeley Private Holdings Ltd
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Gangagen Inc
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462—Lysozyme (3.2.1.17)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44—Guanidine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/06—Lysis of microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01017—Lysozyme (3.2.1.17)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201610182492.XA 2006-05-05 2007-05-04 噬菌体衍生的抗微生物活性剂 Expired - Fee Related CN105884904B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US79788506P 2006-05-05 2006-05-05
US60/797,885 2006-05-05
US90934007P 2007-03-30 2007-03-30
US60/909,340 2007-03-30
CN2007800162540A CN101437532B (zh) 2006-05-05 2007-05-04 噬菌体衍生的抗微生物活性剂

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CN2007800162540A Division CN101437532B (zh) 2006-05-05 2007-05-04 噬菌体衍生的抗微生物活性剂

Publications (2)

Publication Number Publication Date
CN105884904A CN105884904A (zh) 2016-08-24
CN105884904B true CN105884904B (zh) 2020-06-16

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CN201610182492.XA Expired - Fee Related CN105884904B (zh) 2006-05-05 2007-05-04 噬菌体衍生的抗微生物活性剂
CN201310322283.7A Expired - Fee Related CN103436507B (zh) 2006-05-05 2007-05-04 噬菌体衍生的抗微生物活性剂
CN2007800162540A Expired - Fee Related CN101437532B (zh) 2006-05-05 2007-05-04 噬菌体衍生的抗微生物活性剂

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CN201310322283.7A Expired - Fee Related CN103436507B (zh) 2006-05-05 2007-05-04 噬菌体衍生的抗微生物活性剂
CN2007800162540A Expired - Fee Related CN101437532B (zh) 2006-05-05 2007-05-04 噬菌体衍生的抗微生物活性剂

Country Status (10)

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US (6) US8202516B2 (cg-RX-API-DMAC7.html)
EP (1) EP2037946B2 (cg-RX-API-DMAC7.html)
JP (4) JP5383481B2 (cg-RX-API-DMAC7.html)
CN (3) CN105884904B (cg-RX-API-DMAC7.html)
CA (1) CA2651125C (cg-RX-API-DMAC7.html)
DK (1) DK2037946T3 (cg-RX-API-DMAC7.html)
ES (1) ES2536852T3 (cg-RX-API-DMAC7.html)
MX (1) MX2008014150A (cg-RX-API-DMAC7.html)
PT (1) PT2037946E (cg-RX-API-DMAC7.html)
WO (1) WO2007130655A2 (cg-RX-API-DMAC7.html)

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KR20200037425A (ko) * 2012-03-27 2020-04-08 제넨테크, 인크. 재조합 단백질을 위한 개선된 수확 작업
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US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
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US11236314B2 (en) * 2017-03-30 2022-02-01 Bactoclear Holdings Pte. Ltd Chimeric lysm polypeptides
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CN107502603B (zh) * 2017-09-06 2018-06-05 江苏省农业科学院 一种大肠杆菌裂解酶及其制备方法与应用
CN107828769B (zh) * 2017-09-28 2021-03-02 昆明理工大学 一种耐热裂解酶MMPpgh和编码此酶的多核苷酸
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JP7034724B2 (ja) * 2018-01-16 2022-03-14 花王株式会社 ケラチン断片の製造方法
CN113366103A (zh) * 2018-12-21 2021-09-07 诺维信公司 具有肽聚糖降解活性的多肽以及编码其的多核苷酸
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JP6685360B2 (ja) 2020-04-22
JP2014050388A (ja) 2014-03-20
US20220053775A1 (en) 2022-02-24
US9622486B2 (en) 2017-04-18
EP2037946B2 (en) 2023-11-01
CA2651125A1 (en) 2007-11-15
US8748150B2 (en) 2014-06-10
US20120237491A1 (en) 2012-09-20
US8202516B2 (en) 2012-06-19
DK2037946T3 (en) 2015-04-27
EP2037946A2 (en) 2009-03-25
JP5882968B2 (ja) 2016-03-09
PT2037946E (pt) 2015-06-04
US20190297896A1 (en) 2019-10-03
JP2018201525A (ja) 2018-12-27
JP2016112020A (ja) 2016-06-23
EP2037946B1 (en) 2015-02-25
CA2651125C (en) 2016-06-28
JP6416803B2 (ja) 2018-10-31
WO2007130655A3 (en) 2008-07-17
ES2536852T3 (es) 2015-05-28
WO2007130655A2 (en) 2007-11-15
CN101437532A (zh) 2009-05-20
CN101437532B (zh) 2013-08-21
EP2037946A4 (en) 2010-09-22
CN103436507A (zh) 2013-12-11
MX2008014150A (es) 2009-02-04
US10278398B2 (en) 2019-05-07
JP5383481B2 (ja) 2014-01-08
CN105884904A (zh) 2016-08-24
CN103436507B (zh) 2016-04-20
JP2009536033A (ja) 2009-10-08
US20140369986A1 (en) 2014-12-18
US20170318817A1 (en) 2017-11-09
US20090324576A1 (en) 2009-12-31

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