CN105884657B - 氮甲酰氧基取代的氯代二苯甲酮类衍生物 - Google Patents
氮甲酰氧基取代的氯代二苯甲酮类衍生物 Download PDFInfo
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- CN105884657B CN105884657B CN201610278055.8A CN201610278055A CN105884657B CN 105884657 B CN105884657 B CN 105884657B CN 201610278055 A CN201610278055 A CN 201610278055A CN 105884657 B CN105884657 B CN 105884657B
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- Prior art keywords
- tri
- formyl sarcolysine
- dichloro benzophenones
- chloro benzophenone
- analog derivative
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
化合物编号 | 保护率(%) | EC50(μM) |
A1 | 80.1 | 0.4 |
A2 | 60.9 | 4.3 |
A3 | 83.1 | 0.5 |
A4 | 53.4 | 7.4 |
A5 | 70.2 | 2.1 |
A6 | 50.3 | 6.2 |
A7 | 89.0 | 0.3 |
A8 | 93.1 | 0.06 |
A9 | 90.8 | 0.3 |
A10 | 76.7 | 2.0 |
A11 | 87.5 | 0.2 |
A12 | 82.2 | 0.4 |
A13 | 50.0 | 6.7 |
A14 | 63.2 | 5.3 |
LM49 | 70.5 | 0.4 |
Quercetin | 8.8 |
Claims (7)
Priority Applications (1)
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CN201610278055.8A CN105884657B (zh) | 2016-04-29 | 2016-04-29 | 氮甲酰氧基取代的氯代二苯甲酮类衍生物 |
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CN201610278055.8A CN105884657B (zh) | 2016-04-29 | 2016-04-29 | 氮甲酰氧基取代的氯代二苯甲酮类衍生物 |
Publications (2)
Publication Number | Publication Date |
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CN105884657A CN105884657A (zh) | 2016-08-24 |
CN105884657B true CN105884657B (zh) | 2017-08-25 |
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Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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JP6698214B2 (ja) * | 2016-04-29 | 2020-05-27 | 山西医科大学Shanxi Medical University | ベンゾフェノン系化合物の製薬分野における使用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100503559C (zh) * | 2007-02-13 | 2009-06-24 | 武汉大学 | 共轭结构夺氢型光引发剂及其制备方法 |
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2016
- 2016-04-29 CN CN201610278055.8A patent/CN105884657B/zh active Active
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Application publication date: 20160824 Assignee: Shanxi Medical University Asset Management Co., Ltd Assignor: Shanxi Medial University Contract record no.: X2019980000611 Denomination of invention: Nitrogen Formyloxy-substituted chlorobenzophenone derivative Granted publication date: 20170825 License type: Common License Record date: 20191115 |
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Assignee: Shanxi Medical University Asset Management Co.,Ltd. Assignor: SHANXI MEDICAL University Contract record no.: X2019980000611 Date of cancellation: 20210422 |
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