CN105878897A - Function of traditional Chinese medicine fructus amomi on treating depression - Google Patents

Abstract

The invention relates to a traditional Chinese medicine, namely fructus amomi, and the fructus amomi is discovered to have a function of treating depression. The fructus amomi, when used independently or added to and combined with other traditional Chinese medicines, can develop the function of the treating the depression. Cases treated by the fructus amomi are as shown in a Table below: clinical results of treating 600 cases of the depression with the fructus amomi (as shown in Description).

Description

The function of Fructus Amomi treatment depression

(1) technical field

The present invention relates to a kind of Fructus Amomi, no matter single medicinal material uses, and is still added in other Chinese medicine In prescription, all have treatment depression function.

(2) background technology

The overview of depression:

Depression is a kind of with psychiatric condition that depressive mood is main performance.At present, the pressing down of developed country Strongly fragrant disease is 15 kinds of one of reasons that mainly disable.Data show, the U.S. there are about 1 100 ten thousand people every year and suffers from Clinical depression Disease, the homicide rate of clinical depression patient is 10%～15%.National survey data shows, depression from Rate of killing is higher 20 times than population.Predicting the year two thousand twenty, depression will become the mankind being only second to cancer Two big disability-causing factors.Psychosomatic medicine, medicopsychology, psychiatry research data recently shows, typically The prevalence of psychosomatic disease depression has exceeded cardiovascular and cerebrovascular disease and tumor, leaps to the of developed country One.Therefore, analyze the present Research of depression, inquire into the goal in research of depression in the future, further investigation The preventing and treating of depression, is of great importance to human society and family.

The pathogenesis of depression is the most complicated, at present, illustrates the most completely, only have some research and Hypothesis.These hypothesis all have some result of study supports, and the pathogenesis of some depression can be described, but, these are false Say and by other results of study negated, and the pathogenesis of all depressions can not be described completely.

It is now recognized that depression is possibly due to caused by following reason:

1, depression is the different substantiality disease rather than a kind of disease that one group of cause of disease is different with pathogenesis.Due to respectively There is its reason fallen ill and pathogenesis, therefore cannot explain by the same cause of disease and pathogenesis.

2, depression is a kind of disease, but has multiple pathogenic factor and pathogenesis.Many pathogenic factors and morbidity machine System runs up to a certain degree, when exceeding human body self compensatory capacity or compensatory threshold value, just causes morbidity.

Several main hypothesis of depression mechanism is:

1, norepinephrine (NE) function reduction theory in depressive patients brain, it is believed that depression is due in brain (NE) not enough caused, in central nervous system (NE) Content declines, then depression occurs, otherwise, then there is mania.

2, beta receptor, alpha-2 receptor sensitivity theory in depressive patients brain: speculate that depression is due to NE merit in brain Can reduce for a long time, and make beta receptor produce compensatory sensitivity and increase.Postsynaptic beta receptor is super quick can feed back again presynaptic α 2 Receptor is super quick, causes NE to generate release and reduces, depression occurs.

3, depression NE function strengthens theory: having research display depression is that NE raises rather than not enough.

4,5---hydroxytryptamine and receptors hypothesis: think that depression is 5-hydroxy tryptamine in central nervous system (5--HT) Release reduces, and it is caused that synaptic space content declines shortage.

At present, the Western medicine for the treatment of depression has three class medicines,

1, oxidase inhibitor；

2, tricyclic antidepressant preparation；

3, serotonin reuptake inhibitor.

Owing to the cause of disease and the pathogenesis of depression are unclear, so, current antidepressant Western medicine also can only be to play The effect cured the symptoms, not the disease, Western medicine has bigger side effect simultaneously.

As a example by the most conventional antidepressants paroxetine, untoward reaction has:

Blood and lymphsystem: abnormal bleeding, be mainly seen in skin and mucosa.

Immune system: anaphylaxis.

Hormonal system；Antidiuretic hormone secretion abnormal syndrome.

Metabolism and nutrition: loss of appetite, hyponatremia.

Psychological problem: drowsiness, insomnia, confusion, manic reaction.

Nervous system: dizziness, trembles, extrapyramidal symptoms, faints from fear.Serotonin syndrome (cardiopalmus, confusion, Hyperhidrosis, hallucination, hyperreflexia, myoclonus, etc.)

Eye: blurred vision, acute glaucoma.

Cardiovascular system: sinus tachycardia, blood pressure is raised and lowered.

Gastrointestinal tract: feel sick, xerostomia, constipation, diarrhoea, liver transaminases raises.

Skin and subcutaneous tissue: erythra, perspire, photosensitivity reaction.

Kidney and urinary system: urine retention.

Reproductive system: sexual dysfunction.

General reaction: faint, periphery edema.

Chinese medicine is for the understanding of depression: depression belongs to " strongly fragrant disease " in Emotional disorder.And " strongly fragrant disease " can divide For the polytype such as " depression of liver-QI ", " hyperactivity of hesrt-fire and liver-fire ", " phlegm stagnancy vapour lock ".Also have the five internal organs QI and blood deficiency and excess prosperity and decline pathological changes, People can be made to stimulate sensitivity to increase to external world, and toleration declines, and causes seven emotions excessively to cause a disease.

The application of this Fructus Amomi treatment depression, just according to Chinese medicine for the understanding of depression, from conditioning viscera merit Can start with, treat depression, the degree of depth excavates the intension of Fructus Amomi pharmacological effect, has reached the purpose for the treatment of, and has seldom occurred Side effect.

Traditional effect of Fructus Amomi and effect:

Fructus Amomi, is Perenniporia martiusRhizoma Zingiberis RecensSection plant fruits and seeds, be the conventional virtue simply of the traditional Chinese medical science Fragrance medical material.The traditional Chinese medical science is thought, Fructus Amomi mainly acts on the stomach of human body, kidney and spleen, it is possible to circulation of qi promoting seasoning, and Stomach is amusing.Fructus Amomi often coordinates with Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae etc., treats the disease such as fullness in the epigastrium and chest, abdominal distention and little diet.

1. circulation of qi promoting stomach invigorating.The abdominal distention that causes for stagnation of QI in spleen and stomach, anorexia, many withPericarpium Citri Reticulatae, the Radix Aucklandiae With using.

2. removing dampness preventing or arresting vomiting.The gastral cavity all cards of vexed vomiting and nausea caused for taste humidity hysteresis.

The most antiabortive.For vomiting during pregnancy, frequent fetal movement, many with fill blood, kidney-reinforcing drug is with using.

Fructus Amomi pungent temperature row dissipates, removing dampness by means of aromatics, main enter taste, be amusing key medicine for removing dampness for regulating stomach, have concurrently antiabortive it Merit.All wet yang-energies of middle Jiao are stagnant, and the disease such as frequent fetal movement, are conventional product.

(3), summary of the invention

Present invention aim at proposing a kind of Chinese medicine Fructus Amomi and have the function for the treatment of depression, (single makes With or add in prescription use).

Treatment case, see table:

Fructus Amomi treatment depression 600 example clinical effectiveness

Claims (1)

1. the present invention relates to a kind of Fructus Amomi, find that it has the function for the treatment of depression.No matter single medicinal material, is still added in prescription in other Chinese medicine and uses, all played the function for the treatment of depression.