CN114588243B - Two alternately taken Chinese medicinal formulas for treating depression and anxiety - Google Patents
Two alternately taken Chinese medicinal formulas for treating depression and anxiety Download PDFInfo
- Publication number
- CN114588243B CN114588243B CN202110515014.7A CN202110515014A CN114588243B CN 114588243 B CN114588243 B CN 114588243B CN 202110515014 A CN202110515014 A CN 202110515014A CN 114588243 B CN114588243 B CN 114588243B
- Authority
- CN
- China
- Prior art keywords
- root
- prescription
- depression
- anxiety
- deficiency
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 208000019901 Anxiety disease Diseases 0.000 title claims abstract description 26
- 230000036506 anxiety Effects 0.000 title claims abstract description 20
- 239000003814 drug Substances 0.000 claims abstract description 21
- 230000007812 deficiency Effects 0.000 claims abstract description 8
- 241000173529 Aconitum napellus Species 0.000 claims description 19
- 235000006886 Zingiber officinale Nutrition 0.000 claims description 19
- 229940023019 aconite Drugs 0.000 claims description 19
- 235000008397 ginger Nutrition 0.000 claims description 19
- 241000132012 Atractylodes Species 0.000 claims description 13
- 241001522129 Pinellia Species 0.000 claims description 11
- 229940107666 astragalus root Drugs 0.000 claims description 11
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 10
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 10
- 235000017443 Hedysarum boreale Nutrition 0.000 claims description 10
- 235000007858 Hedysarum occidentale Nutrition 0.000 claims description 10
- 241000237502 Ostreidae Species 0.000 claims description 10
- 244000197580 Poria cocos Species 0.000 claims description 10
- 235000008599 Poria cocos Nutrition 0.000 claims description 10
- 210000000988 bone and bone Anatomy 0.000 claims description 10
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 claims description 10
- 235000020636 oyster Nutrition 0.000 claims description 10
- 241000096284 Gynochthodes officinalis Species 0.000 claims description 9
- 238000011282 treatment Methods 0.000 claims description 9
- 244000037364 Cinnamomum aromaticum Species 0.000 claims description 8
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims description 8
- 241000209020 Cornus Species 0.000 claims description 8
- 241000361919 Metaphire sieboldi Species 0.000 claims description 8
- 235000017803 cinnamon Nutrition 0.000 claims description 8
- 210000000582 semen Anatomy 0.000 claims description 8
- 239000010975 amethyst Substances 0.000 claims description 7
- 235000013399 edible fruits Nutrition 0.000 claims description 7
- 208000020401 Depressive disease Diseases 0.000 claims description 4
- 241000305492 Gastrodia Species 0.000 claims description 4
- 240000008866 Ziziphus nummularia Species 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 4
- 241001127714 Amomum Species 0.000 claims description 3
- 235000003392 Curcuma domestica Nutrition 0.000 claims description 3
- 241000157491 Morinda Species 0.000 claims description 3
- 235000003373 curcuma longa Nutrition 0.000 claims description 3
- 235000017524 noni Nutrition 0.000 claims description 3
- 235000013976 turmeric Nutrition 0.000 claims description 3
- 244000273928 Zingiber officinale Species 0.000 claims 4
- WTPPRJKFRFIQKT-UHFFFAOYSA-N 1,6-dimethyl-8,9-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione;1-methyl-6-methylidene-8,9-dihydro-7h-naphtho[1,2-g][1]benzofuran-10,11-dione Chemical compound O=C1C(=O)C2=C3CCCC(=C)C3=CC=C2C2=C1C(C)=CO2.O=C1C(=O)C2=C3CCC=C(C)C3=CC=C2C2=C1C(C)=CO2 WTPPRJKFRFIQKT-UHFFFAOYSA-N 0.000 claims 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 claims 1
- 241000675108 Citrus tangerina Species 0.000 claims 1
- 240000006766 Cornus mas Species 0.000 claims 1
- 244000163122 Curcuma domestica Species 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000010453 quartz Substances 0.000 claims 1
- 244000132619 red sage Species 0.000 claims 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 abstract description 21
- 230000000694 effects Effects 0.000 abstract description 16
- 210000004185 liver Anatomy 0.000 abstract description 16
- 210000000952 spleen Anatomy 0.000 abstract description 12
- 230000036528 appetite Effects 0.000 abstract description 11
- 235000019789 appetite Nutrition 0.000 abstract description 11
- 208000024891 symptom Diseases 0.000 abstract description 8
- 239000008280 blood Substances 0.000 abstract description 5
- 210000004369 blood Anatomy 0.000 abstract description 5
- 230000003203 everyday effect Effects 0.000 abstract description 5
- 206010002869 Anxiety symptoms Diseases 0.000 abstract description 4
- 229940126680 traditional chinese medicines Drugs 0.000 abstract description 4
- 230000008506 pathogenesis Effects 0.000 abstract description 3
- 230000036765 blood level Effects 0.000 abstract description 2
- 230000009982 effect on human Effects 0.000 abstract description 2
- 239000013589 supplement Substances 0.000 abstract 1
- 229940126585 therapeutic drug Drugs 0.000 abstract 1
- 241000234314 Zingiber Species 0.000 description 15
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 12
- 241000723347 Cinnamomum Species 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 230000036651 mood Effects 0.000 description 7
- 238000010792 warming Methods 0.000 description 7
- 201000010099 disease Diseases 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 206010027940 Mood altered Diseases 0.000 description 4
- 240000007164 Salvia officinalis Species 0.000 description 4
- 239000000935 antidepressant agent Substances 0.000 description 4
- 229940005513 antidepressants Drugs 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 230000008451 emotion Effects 0.000 description 4
- 235000005412 red sage Nutrition 0.000 description 4
- 241000756943 Codonopsis Species 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 3
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 3
- 230000006399 behavior Effects 0.000 description 3
- 210000000232 gallbladder Anatomy 0.000 description 3
- 206010022437 insomnia Diseases 0.000 description 3
- 206010010144 Completed suicide Diseases 0.000 description 2
- 241000759833 Cornus officinalis Species 0.000 description 2
- 244000164480 Curcuma aromatica Species 0.000 description 2
- 235000003398 Curcuma aromatica Nutrition 0.000 description 2
- 244000008991 Curcuma longa Species 0.000 description 2
- 206010012239 Delusion Diseases 0.000 description 2
- 206010013954 Dysphoria Diseases 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 241000243684 Lumbricus Species 0.000 description 2
- 206010033557 Palpitations Diseases 0.000 description 2
- 208000028017 Psychotic disease Diseases 0.000 description 2
- 208000037386 Typhoid Diseases 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 230000000949 anxiolytic effect Effects 0.000 description 2
- 229940049706 benzodiazepine Drugs 0.000 description 2
- 230000001914 calming effect Effects 0.000 description 2
- 231100000868 delusion Toxicity 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 238000002651 drug therapy Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 230000003014 reinforcing effect Effects 0.000 description 2
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 description 2
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 description 2
- 239000003775 serotonin noradrenalin reuptake inhibitor Substances 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 201000008297 typhoid fever Diseases 0.000 description 2
- 229940126673 western medicines Drugs 0.000 description 2
- AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 description 1
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 1
- WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 description 1
- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 description 1
- ZEUITGRIYCTCEM-KRWDZBQOSA-N (S)-duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 description 1
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 241000282994 Cervidae Species 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- GDLIGKIOYRNHDA-UHFFFAOYSA-N Clomipramine Chemical compound C1CC2=CC=C(Cl)C=C2N(CCCN(C)C)C2=CC=CC=C21 GDLIGKIOYRNHDA-UHFFFAOYSA-N 0.000 description 1
- 241000052343 Dares Species 0.000 description 1
- 206010013082 Discomfort Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 208000004547 Hallucinations Diseases 0.000 description 1
- 241000282414 Homo sapiens Species 0.000 description 1
- 239000009636 Huang Qi Substances 0.000 description 1
- 241001673966 Magnolia officinalis Species 0.000 description 1
- 208000037490 Medically Unexplained Symptoms Diseases 0.000 description 1
- 240000000233 Melia azedarach Species 0.000 description 1
- 208000036626 Mental retardation Diseases 0.000 description 1
- 229940123685 Monoamine oxidase inhibitor Drugs 0.000 description 1
- 208000019022 Mood disease Diseases 0.000 description 1
- 241001229135 Nassa Species 0.000 description 1
- AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 description 1
- 206010062519 Poor quality sleep Diseases 0.000 description 1
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 1
- 206010042464 Suicide attempt Diseases 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 229940123445 Tricyclic antidepressant Drugs 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 229960004538 alprazolam Drugs 0.000 description 1
- VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 1
- 210000003056 antler Anatomy 0.000 description 1
- 239000002249 anxiolytic agent Substances 0.000 description 1
- 229940005530 anxiolytics Drugs 0.000 description 1
- 150000001557 benzodiazepines Chemical class 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229960002495 buspirone Drugs 0.000 description 1
- QWCRAEMEVRGPNT-UHFFFAOYSA-N buspirone Chemical compound C1C(=O)N(CCCCN2CCN(CC2)C=2N=CC=CN=2)C(=O)CC21CCCC2 QWCRAEMEVRGPNT-UHFFFAOYSA-N 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 208000023652 chronic gastritis Diseases 0.000 description 1
- 229960001653 citalopram Drugs 0.000 description 1
- 229960004606 clomipramine Drugs 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 229960003529 diazepam Drugs 0.000 description 1
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 229960005426 doxepin Drugs 0.000 description 1
- ODQWQRRAPPTVAG-GZTJUZNOSA-N doxepin Chemical compound C1OC2=CC=CC=C2C(=C/CCN(C)C)/C2=CC=CC=C21 ODQWQRRAPPTVAG-GZTJUZNOSA-N 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 229960002866 duloxetine Drugs 0.000 description 1
- 229960004341 escitalopram Drugs 0.000 description 1
- WSEQXVZVJXJVFP-FQEVSTJZSA-N escitalopram Chemical compound C1([C@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-FQEVSTJZSA-N 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 229960002464 fluoxetine Drugs 0.000 description 1
- 229960004038 fluvoxamine Drugs 0.000 description 1
- CJOFXWAVKWHTFT-XSFVSMFZSA-N fluvoxamine Chemical compound COCCCC\C(=N/OCCN)C1=CC=C(C(F)(F)F)C=C1 CJOFXWAVKWHTFT-XSFVSMFZSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000011221 initial treatment Methods 0.000 description 1
- 208000024714 major depressive disease Diseases 0.000 description 1
- 230000008897 memory decline Effects 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 229960001785 mirtazapine Drugs 0.000 description 1
- RONZAEMNMFQXRA-UHFFFAOYSA-N mirtazapine Chemical compound C1C2=CC=CN=C2N2CCN(C)CC2C2=CC=CC=C21 RONZAEMNMFQXRA-UHFFFAOYSA-N 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000002899 monoamine oxidase inhibitor Substances 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 239000002767 noradrenalin uptake inhibitor Substances 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 229940127221 norepinephrine reuptake inhibitor Drugs 0.000 description 1
- 229960002296 paroxetine Drugs 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000003772 serotonin uptake inhibitor Substances 0.000 description 1
- 229960002073 sertraline Drugs 0.000 description 1
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 description 1
- 230000036299 sexual function Effects 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- CEIJFEGBUDEYSX-FZDBZEDMSA-N tandospirone Chemical compound O=C([C@@H]1[C@H]2CC[C@H](C2)[C@@H]1C1=O)N1CCCCN(CC1)CCN1C1=NC=CC=N1 CEIJFEGBUDEYSX-FZDBZEDMSA-N 0.000 description 1
- 229950000505 tandospirone Drugs 0.000 description 1
- 239000003029 tricyclic antidepressant agent Substances 0.000 description 1
- 229960004688 venlafaxine Drugs 0.000 description 1
- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/746—Morinda
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Abstract
The invention relates to the field of traditional Chinese medicines, and discloses two traditional Chinese medicine formulas for treating depression and anxiety by alternately taking, namely a Huitian prescription and a deficiency-labor prescription. The recipe of returning to the sky warms and supplements the spleen and the kidney, promotes appetite and calms heart spirit; the deficiency-labor formula soothes liver and relieve depression, tonify qi and strengthen kidney, and promote spirit. The prevalence rate of depression and anxiety disorder is high, the harm is large, the recurrence rate is high, and the effective therapeutic drugs with few side effects are lacked. Clinically, most patients suffering from depression and anxiety have symptoms of deficiency besides stagnation of liver and gall pulse, usually the left and right kidney pulse are deep, and the patients are difficult to take care of the whole pathogenesis by using only one prescription. The two traditional Chinese medicine formulas of the project have the effects of soothing liver and relieving depression, and simultaneously replenishing qi to invigorate spleen, tonifying kidney and replenishing essence. The deficiency labor prescription is biased to the left and the heaven prescription is biased to the right, and the two prescriptions are taken alternately every day, so that qi and blood yin and yang on the left and right sides can be balanced and supplemented while soothing liver and relieving depression; not only relieve depression and anxiety symptoms, but also promote appetite and improve qi and blood level of patients, and has little side effect on human bodies.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, in particular to a formula of two traditional Chinese medicines for treating depression and anxiety by alternately taking.
Background
Depression, also known as depressive disorder, is a major type of mood disorder with marked and persistent depression as a major clinical feature. Clinically, the mood is dissatisfied with the mood, the mood can be subsided from smoldering to sad and absolute, the user can feel depressed, even pessimistic and aversive, and suicide attempts or behaviors can be realized; even wood stiffness occurs; some cases have significant anxiety and motor agitation; in severe cases, psychotic symptoms such as hallucinations and delusions may occur. Most cases have a tendency to recur. Anxiety disorder is a kind of nervous disorder mainly represented by anxiety emotion, including acute anxiety and chronic anxiety, and frequently has dizziness, chest distress, palpitation, dyspnea, dry mouth, frequent urination, urgent urination, sweating, tremor, and motor anxiety. Anxiety is not a real threat and is not very stressed to the extent of reality. The data published in 2019 of Chinese mental health survey show that: the lifetime prevalence of depressive disorders is 3.4% and that of anxiety disorders is 7.6%. The two diseases have high prevalence rate, heavy social burden and easy repeated attack.
Drug therapy is the primary treatment for depressive episodes above moderate. The current first-line antidepressants in clinic mainly include selective 5-hydroxytryptamine reuptake inhibitors (SSRI, representing the drugs fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram and escitalopram), 5-hydroxytryptamine and norepinephrine reuptake inhibitors (SNRI, representing the drugs venlafaxine and duloxetine), norepinephrine and specific 5-hydroxytryptamine antidepressants (NaSSA, representing the drug mirtazapine), and the like. The traditional tricyclic antidepressants, tetracyclic antidepressants and monoamine oxidase inhibitors have the advantages of obviously reduced application due to larger adverse reaction. The treatment of anxiety disorder is also based on drug therapy, including benzodiazepines (such as diazepam, alprazolam, esmolam, etc.), non-benzodiazepine anxiolytics (such as buspirone, tandospirone), and the existing antidepressants have anxiolytic effects, such as doxepin, clomipramine, SSRI, SNRI, etc.
Although depression and anxiety differ in clinical manifestations, abnormalities in monoamine neurotransmitters, especially 5-hydroxytryptamine (5-HT), exist both in etiology and in mechanism. Therapeutically, selective 5-hydroxytryptamine reuptake inhibitors may also be used.
At present, most of medicaments for treating depression and anxiety are western medicaments, have considerable side effects on gastrointestinal tract and sexual functions, and are easy to cause emotion to turn to the other extreme of excitation, namely 'turning to agitation'. The traditional Chinese medicine and the Chinese patent medicine which are partially developed only pay attention to soothing liver and relieving Yu Zheyi pathogenesis, but do not pay attention to the pathogenesis of the body deficiency, and the consequence is that the curative effect is not durable or the patient cannot tolerate.
Disclosure of Invention
The invention aims to provide two alternative Chinese medicinal formulas for treating depression and anxiety, namely a Huitian formula and a deficiency-labor formula, for solving the problems.
The invention realizes the above purpose through the following technical scheme:
the Huitian prescription is prepared from the following raw materials in parts by weight: 15g of prepared aconite root (decocted first), 15g of astragalus root, 20g of pilose asiabell root, 20g of white atractylodes rhizome, 10g of swordlike atractylodes rhizome, 20g of dried ginger, 20g of honey-fried licorice root, 15g of poria cocos, 15g of ginger processed pinellia tuber, 10g of dried orange peel, 15g of raw dragon bone, 20g of raw oyster, 15g of amethyst, 25g of dogwood fruit, 15g of morinda root, 15g of deer horn (frost), 10g of cassia bark (later lower part), 5g of earthworm, 5g of red sage root and 5g of turmeric root-tuber. Efficacy: replenishing qi to invigorate the spleen, warming and invigorating the spleen and the kidney, stimulating appetite, calming heart spirit and improving energy. Treating depression, anxiety, insomnia, chronic gastritis, etc., with symptoms of deep and weak right ulnar pulse and poor appetite. It has the actions of returning to the sky.
The deficiency-labor prescription is prepared from the following raw materials in parts by weight: 30g of prepared aconite root (decocted first), 10g of cassia twig, 10g of radix curcumae, 5g of gastrodia tuber, 15g of wild jujube seed, 20g of raw dragon bone, 20g of raw oyster, 10g of amethyst, 20g of semen cuscutae, 20g of morinda officinalis, 30g of astragalus root, 20g of pilose asiabell root, 20g of bighead atractylodes rhizome, 20g of dried ginger, 5g of honey-fried licorice root, 15g of poria cocos, 15g of ginger processed pinellia tuber, 10g of dried orange peel, 15g of villous amomum fruit, 10g of cinnamon (later) and 5g of earthworm. Efficacy: liver soothing, qi stagnation relieving, qi invigorating, kidney reinforcing, and mental retardation improving effects. Treating depression, anxiety, insomnia and sub-health state, and deep and weak left ulnar pulse.
Clinically, most patients suffering from depression and anxiety have symptoms of deficiency besides stagnation of liver and gall pulse, namely, deep and weak kidney pulse. In addition, the left and right kidney vessels are heavy, and the patient is difficult to take care of the disease mechanism by using only one prescription. The two traditional Chinese medicine formulas of the project have the effects of soothing liver and relieving depression, and simultaneously replenishing qi to invigorate spleen, tonifying kidney and replenishing essence. The deficiency labor prescription is biased to the left and the heaven prescription is biased to the right, and the two prescriptions are taken alternately every day, so that qi and blood yin and yang on the left and right sides can be balanced and supplemented while soothing liver and relieving depression; not only relieve depression and anxiety symptoms, but also promote appetite, promote spirit, improve qi and blood level of patients, and have little side effect on human bodies.
The two traditional Chinese medicine formulas have the following functions:
returning to the sky: the prepared aconite root decoction is used as a main frame, and has the effects of warming and invigorating spleen and kidney, tonifying qi by astragalus root, regulating qi by pinellia tuber and dried orange peel, dispelling dampness by poria cocos, and warming and invigorating kidney yang by morinda officinalis, cornu cervi (degelatinatum) and cinnamon, so as to achieve the effects of replenishing qi, strengthening spleen, dispelling dampness and warming and invigorating spleen and kidney; fructus Corni fills yin of liver and kidney, and is combined with Os Draconis, concha Ostreae and Fluoritum to induce fire to descend, and fill yin and yang of kidney; lumbricus, saviae Miltiorrhizae radix, and radix Curcumae have effects of dispersing stagnated liver qi for relieving qi stagnation, promoting blood circulation, and purging liver and gallbladder fire. The comprehensive prescription can well tonify right path, clear left path, warm and tonify lower element, and has the effects of tonifying yang without excessive internal heat, replenishing qi to invigorate spleen, warming and tonifying spleen and kidney, stimulating appetite, stabilizing mind and improving energy.
The deficiency-labor formula: the prescription combines Gui Ganlong decoction, astragali radix decoction, zizyphi Spinosae semen decoction in Shang Han Lun-xu-Er-Teng (typhoid fever theory and consumptive disease) together, and has effects of invigorating kidney and replenishing essence, and astringing Yang Qianyang for treating yang-qi of lower jiao: ramulus Cinnamomi and radix Aconiti lateralis Preparata warm yang, and can promote the growth of yang qi in order, and radix astragali, radix Codonopsis and Atractylodis rhizoma can invigorate spleen and replenish qi, poria can dispel dampness, cortex Cinnamomi can warm kidney yang, rhizoma Gastrodiae and semen Ziziphi Spinosae can nourish yin blood, rhizoma Pinelliae, pericarpium Citri Tangerinae and fructus Amomi can regulate qi and invigorate spleen, radix Curcumae and Lumbricus can dispel liver and gallbladder stagnation, and can clear and reduce gallbladder fire. The whole formula can be seen, the effects of tonifying left channel, warming and tonifying lower element are achieved, and the effects of soothing liver and relieving depression, tonifying qi and nourishing blood, reinforcing kidney and dredging channels and calming mind are achieved.
The dosage of aconite in the invention reaches 30g and exceeds the dosage of pharmacopoeia. Li Kelao traditional Chinese medicine has strictly examined the usual dosages of ancient Chinese medicines: the dosage of the aconite root in the Sheng Zhang Zhongjing is generally 1-3, the average weight is about 15g according to the wild aconite root collected in modern times, and the average weight is 31 g for 1, so that the dosage of the aconite root in the Shang Han Lun is presumed to be generally 15-90 g. Is used in an amount far higher than 15g of pharmacopoeia. In the present invention, fu Zi and ban Xia are used together, which belongs to the category of eighteen antagonisms. The diagnosis and treatment of traditional Chinese medicine originates from Shang Han Dynasty Zhang Zhongjing (treatise on Cold-induced miscellaneous diseases), and the classic is not discussed in eighteen ways. The eighteen-part is the most damaging part of the moat 'half-way Bei Lian achnathus' because the latter extends 'aconite' to aconite. The people depend on yang qi to grow, and the book name of the theory of typhoid fever shows that the disease of human beings is due to cold, and the pathological products are phlegm and fluid retention and blood stasis. The key herb of aconite root for expelling cold, the key herb of aconite root for generating yang and tonifying primordial energy, the ban Xiao Hu has the key actions of astringing, eliminating phlegm and expelling decoction. If you press the eighteen adverse effects of the recipe, you can't remove cold, yang failure can't take place, pathological products can't be removed, and you get the cure? Zhi Gai ban Xia Shang Gansui gan Cao is combined with Wu Tou ban Xia in Chi Wan Fang (Red pill of jin Kui Yao LQ.Y.E.). It is known that the eighteen antagonisms of the latter person completely violates the spirit of the first-stage syndrome differentiation and the rule of "the disease is the medicine". Modern famous doctor Zhu Liangchun issued 2011 suggests that eighteen negatives must be thoroughly negated. The inventor clinically applies the scheme to treat hundreds of patients suffering from depression and anxiety, and has no obvious side effect.
Compared with the prior art, the invention has the following advantages:
the formula can rapidly improve depression and anxiety symptoms. By warming yang, soothing liver, relieving depression, and relieving liver and gall depression, depression and anxiety symptoms are relieved, and anti-depression western medicines can be taken rarely or even not taken during taking the traditional Chinese medicines.
The formula can rapidly improve insomnia symptoms. Sleep improvement is generally achieved about 4 days after taking the medicine.
The formula can rapidly treat somatic symptoms such as poor appetite, general discomfort and the like. The formula contains a large amount of spleen-invigorating and spleen-activating medicines, and can quickly improve the symptoms of poor appetite. After the diet is improved, the energy supply is recovered, and the body discomfort is also improved.
The formula can gradually improve the attention and the memory, and recover the learning and working capacities. The traditional Chinese medicine considers that the attention and memory decline is related to kidney essence deficiency. The formula contains the medicines for tonifying kidney and replenishing essence, such as semen cuscutae, morinda officinalis, pulp of dogwood fruit, cornu cervi degelatinatum and the like, and can quickly replenish kidney essence and improve attention and memory.
The formula is convenient to use and simple in syndrome differentiation. The formulation of the present invention can be used as long as the pulse is deep, wiry and weak. The left side is more sinking and is more weak, the right side is more sinking and is more heavyweight, even the pulse condition can be treated by one side alone. The two prescriptions are taken alternately, the balance of the pulse conditions on the left and right sides is improved, and the symptoms of the patients can be continuously improved until the patients are healed.
Detailed Description
The invention will be further described with reference to specific examples, but the invention is not limited to these examples.
Embodiment case 1:
patients Yang Mou, women, 17 years old, may develop bad mood due to learning pressure before 3 years, feel that life is not meant, do not interest everything, feel that life is not happy, and even have suicide thoughts. Poor sleep, difficulty in falling asleep, poor appetite, 3 days of stool, pale tongue with white coating, deep and wiry pulse. The recipe is administered alternately daily with the decoction for returning to the sky and the recipe for treating deficiency. The prescription is as follows: returning to the sky: 15g of prepared aconite root (decocted first), 15g of astragalus root, 20g of pilose asiabell root, 20g of white atractylodes rhizome, 10g of rhizoma atractylodis, 20g of dried ginger, 20g of honey-fried licorice root, 15g of poria cocos, 15g of ginger processed pinellia tuber, 10g of dried orange peel, 15g of raw dragon bone, 20g of raw oyster, 15g of amethyst (decocted first), 25g of cornus officinalis, 15g of morinda officinalis, 15g of cornu cervi degelatinatum, 10g of cinnamon (later), 5g of earthworm, 5g of red sage root and 5g of curcuma aromatica. The deficiency-labor formula: 30g of prepared aconite root (decocted first), 10g of cassia twig, 10g of radix curcumae, 15g of spina date seed, 20g of raw dragon bone (decocted first), 20g of raw oyster (decocted first), 10g of amethyst (decocted first), 20g of semen cuscutae, 20g of morinda officinalis, 35g of astragalus root, 20g of radix codonopsis pilosulae, 20g of bighead atractylodes rhizome, 20g of dried ginger, 5g of honey-fried licorice root, 20g of poria cocos, 15g of ginger processed pinellia tuber, 10g of dried orange peel, 15g of fructus amomi and 10g of cinnamon (later). Each 5 doses are taken alternately every day. After 10 days, sleep is improved, mood is improved, and treatment is consolidated continuously.
Embodiment case 2:
the patient Zhang Mou, men, 37 years old, has no obvious incentive to be stressed and worry about the situation before 5 years, always feels something bad, and is always in palpitation, fear and even influenced by driving, and the driver is stressed and afraid of high speed as soon as the speed of the vehicle is fast. Sleep is also poor, and is difficult to fall asleep and easy to wake. Several hospitals have been diagnosing anxiety disorder, and there is no obvious improvement after administration. At present, the patient still dares to get high speed, afraid of driving, bad sleep, stomach and stool, pale red tongue with white coating, deep right-chi pulse and wiry and slippery left pulse. It is used singly in Hui Tian Tang. The prescription is as follows: returning to the sky: 15g of prepared aconite root (decocted first), 10g of astragalus root, 20g of pilose asiabell root, 20g of white atractylodes rhizome, 10g of rhizoma atractylodis, 20g of dried ginger, 20g of honey-fried licorice root, 15g of poria cocos, 15g of ginger processed pinellia tuber, 10g of dried orange peel, 20g of raw dragon bone, 20g of raw oyster, 10g of amethyst (decocted first), 25g of cornus officinalis, 15g of morinda officinalis, 10g of antler slice, 10g of cinnamon, 5g of earthworm, 5g of red sage root and 5g of curcuma aromatica. 10 doses, one dose per day. After 10 days, anxiety is obviously improved, driving is not obviously stressed or worried, the vehicle speed is fast, and the sleeping is improved. The medicine is taken continuously to consolidate the treatment.
Embodiment 3:
the patient Mou, woman, 13 years old, had no obvious incentive to develop bad mood, felt no meaning in life, did not interest in everything, felt no happy thing in life, even had suicide thoughts. And suspects that someone is monitoring and that someone is harmful to her. Major depressive episodes with psychotic symptoms are diagnosed, and western medicines are taken for treatment all the time. However, the mood is still poor, the interest is reduced, the negative idea is provided, people are suspected to monitor, the sleep is difficult to fall asleep, the stomach is easy, the stool is not smooth, the tongue is light red with white coating, the right pulse is wiry, and the left pulse is deep and weak. Is administered alone by deficiency-labor. The prescription is as follows: the deficiency-labor formula: 30g of prepared aconite root (decocted first), 8g of cassia twig, 10g of radix curcumae, 10g of gastrodia tuber, 15g of wild jujube seed, 25g of raw dragon bone (decocted first), 25g of raw oyster (decocted first), 20g of semen cuscutae, 20g of morinda officinalis, 20g of astragalus root, 15g of pilose asiabell root, 20g of bighead atractylodes rhizome, 20g of dried ginger, 5g of honey-fried licorice root, 15g of poria cocos, 15g of ginger processed pinellia tuber, 10g of dried orange peel, 15g of villous amomum fruit and 10g of cinnamon (later). 7 doses, one dose per day. After one week, the mood is improved, the emotion is stable, delusions and shaking are performed, the sleep is improved, and the treatment is consolidated continuously.
Embodiment 4:
the patient Wang Mou, the woman, the age of 14 years, has no obvious cause and gradually has bad mood before 2 years, feels that life does not have meaning, does not bring fun to everything, feels that life is very painful, and in order to relieve psychological pain, the patient often holds a knife to scratch his wrist, and the psychological pain is relieved through the physical pain. In local psychiatric hospitals, the treatment is diagnosed as depression onset, and the effect is not obvious after administration. At present, the patients still have bad mood, dysphoria, self-disabled behavior, difficult sleep, poor appetite, pale tongue with white coating, deep and wiry pulse. The Huitian decoction and the deficiency-labor prescription are taken alternately every day. The prescription is as follows: returning to the sky: 15g of prepared aconite root (decocted first), 10g of astragalus root, 20g of pilose asiabell root, 20g of white atractylodes rhizome, 10g of swordlike atractylodes rhizome, 20g of dried ginger, 20g of honey-fried licorice root, 15g of poria cocos, 15g of ginger processed pinellia tuber, 10g of officinal magnolia bark, 20g of raw dragon bone, 20g of raw oyster (decocted first), 25g of dogwood fruit, 15g of morinda root, 15g of cornu cervi degelatinatum, 10g of cassia bark (later lower part), 5g of earthworm, 5g of red sage root and 5g of turmeric root-tuber. The deficiency-labor formula: 35g of prepared aconite root (decocted first), 5g of cassia twig, 10g of radix curcumae, 10g of gastrodia tuber, 10g of wild jujube seed, 5g of earthworm, 20g of raw dragon bone (decocted first), 20g of raw oyster (decocted first), 10g of amethyst (decocted first), 20g of semen cuscutae, 20g of morinda officinalis, 30g of astragalus root, 20g of radix codonopsis pilosulae, 20g of white atractylodes rhizome, 20g of dried ginger, 5g of honey-fried licorice root, 20g of poria cocos, 15g of purified pinellia tuber, 15g of dried orange peel, 15g of fructus amomi and 10g of cinnamon (later). Each 5 doses are taken alternately every day. After 10 days, the mood is improved, the emotion is stable, obvious dysphoria and self-disabled behaviors are avoided, sleep is improved, appetite is improved, and the treatment is consolidated continuously.
The above described embodiments represent only a few embodiments of the present invention, which are described in more detail and are not to be construed as limiting the scope of the present invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention.
Claims (2)
1. A Chinese medicinal composition for treating depression and anxiety is characterized by being alternately taken: the traditional Chinese medicine composition consists of a Huitian prescription and a deficiency labor prescription, wherein the Huitian prescription is prepared from the following raw materials in parts by weight: 15g of prepared aconite root, 15g of astragalus root, 20g of pilose asiabell root, 20g of largehead atractylodes rhizome, 10g of swordlike atractylodes rhizome, 20g of dried ginger, 20g of honey-fried licorice root, 15g of Indian buead, 15g of ginger processed pinellia tuber, 10g of tangerine peel, 15g of raw dragon bone, 20g of raw oyster, 15g of quartz, 25g of dogwood fruit, 15g of morinda root, 15g of cornu cervi degelatinatum, 10g of cassia bark, 5g of earthworm, 5g of danshen root and 5g of turmeric root-tuber; the deficiency-labor prescription is prepared from the following raw materials in parts by weight: 30g of prepared aconite root, 10g of cassia twig, 10g of radix curcumae, 5g of gastrodia tuber, 15g of wild jujube seed, 20g of raw dragon bone, 20g of raw oyster, 10g of amethyst, 20g of semen cuscutae, 20g of morinda officinalis, 30g of astragalus root, 20g of pilose asiabell root, 20g of bighead atractylodes rhizome, 20g of dried ginger, 5g of honey-fried licorice root, 15g of poria cocos, 15g of ginger processed pinellia tuber, 10g of dried orange peel, 15g of villous amomum fruit, 10g of cinnamon and 5g of earthworm.
2. Use of a Chinese medicinal composition according to claim 1 in the manufacture of a medicament for the treatment of depression, anxiety.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110515014.7A CN114588243B (en) | 2021-05-11 | 2021-05-11 | Two alternately taken Chinese medicinal formulas for treating depression and anxiety |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110515014.7A CN114588243B (en) | 2021-05-11 | 2021-05-11 | Two alternately taken Chinese medicinal formulas for treating depression and anxiety |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114588243A CN114588243A (en) | 2022-06-07 |
| CN114588243B true CN114588243B (en) | 2024-01-05 |
Family
ID=81803539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110515014.7A Active CN114588243B (en) | 2021-05-11 | 2021-05-11 | Two alternately taken Chinese medicinal formulas for treating depression and anxiety |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114588243B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1279090A (en) * | 1999-06-25 | 2001-01-10 | 刘永香 | Powdered medicine for conditioning viscera and whole body |
| CN105920553A (en) * | 2016-05-18 | 2016-09-07 | 张旭东 | Combined reagent for treating mental and neurotic symptoms |
| CN111743994A (en) * | 2020-07-31 | 2020-10-09 | 南京同仁堂药业有限责任公司 | Traditional Chinese medicine preparation for warming middle-jiao and invigorating spleen and preparation method thereof |
| CN114306563A (en) * | 2022-01-18 | 2022-04-12 | 江苏省中医院 | Gynecological climacteric menstruation moxibustion and preparation method thereof |
-
2021
- 2021-05-11 CN CN202110515014.7A patent/CN114588243B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1279090A (en) * | 1999-06-25 | 2001-01-10 | 刘永香 | Powdered medicine for conditioning viscera and whole body |
| CN105920553A (en) * | 2016-05-18 | 2016-09-07 | 张旭东 | Combined reagent for treating mental and neurotic symptoms |
| CN111743994A (en) * | 2020-07-31 | 2020-10-09 | 南京同仁堂药业有限责任公司 | Traditional Chinese medicine preparation for warming middle-jiao and invigorating spleen and preparation method thereof |
| CN114306563A (en) * | 2022-01-18 | 2022-04-12 | 江苏省中医院 | Gynecological climacteric menstruation moxibustion and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 柴胡加龙骨牡蛎汤合黛力新治疗脑卒中后抑郁30例;占国等;《江西中医药》;20150515(第05期);全文 * |
| 柴胡龙骨牡蛎汤联合抗抑郁药物治疗脑卒中后抑郁的肝肾阴虚证的临床研究;金榜;《陕西中医》;20160205(第02期);全文 * |
| 灸法配合益气健脾方治疗卒中后混合性焦虑抑郁障碍的临床研究;舒畅等;《中西医结合心脑血管病杂志》;20141010(第10期);全文 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114588243A (en) | 2022-06-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101559195B (en) | Epilepsy therapy capsule and preparation method thereof | |
| CN103349756A (en) | Traditional Chinese medicine composition for treating depression | |
| CN102813839B (en) | Compound medicine for treating cluster headache syndrome | |
| CN113842413A (en) | A Chinese medicinal composition for treating male infertility | |
| CN102512633B (en) | Traditional Chinese medicinal composition for treating insomnia | |
| CN101543621B (en) | Drug for curing diabetes | |
| CN103800888B (en) | A kind of Chinese medicine composition treating neurasthenia | |
| CN103127472A (en) | Traditional Chinese medicine compound for refractory insomnia | |
| CN1557373A (en) | Chinese medicine preparation for treating climacteric metancholia of liver depression and qi stagnation | |
| CN101708310B (en) | Chinese medicinal preparation for treating neurotica | |
| CN102743671A (en) | Chinese medicine composition for treating cerebral concussion sequela | |
| CN114588243B (en) | Two alternately taken Chinese medicinal formulas for treating depression and anxiety | |
| CN104771652A (en) | Vertigo treating traditional Chinese medicine composition | |
| CN102327436A (en) | Traditional Chinese medicine composition for treating edema during menstruation | |
| CN104606561A (en) | Traditional Chinese medicinal composition for treating spontaneous perspiration | |
| CN101195003B (en) | Proprietary Chinese medicine for treating apoplexy and sequela | |
| CN1730093A (en) | Chinese traditional medicine preparation for treating cancer and application thereof | |
| CN102293946A (en) | Chinese medicinal composition for treating vertigo | |
| CN102836241B (en) | Traditional Chinese medicine combination for treating neck shoulder lumbocrural pains caused by spinal degenerative change | |
| CN105535849A (en) | Traditional Chinese medicine for treating liver depression insomnia | |
| CN101703660B (en) | Anti-aging medicament | |
| CN101874864B (en) | Chinese traditional medicament for treating cervical vertigo diseases | |
| CN104547642A (en) | Tradtional Chinese medicine composition for treating female fibromyalgia syndromes | |
| CN110051812A (en) | A kind of strengthening vital QI to eliminate pathogenic factors Chinese medicine and preparation method thereof | |
| CN116211974B (en) | Traditional Chinese medicine composition for improving microcirculation of human body |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |