CN105920553A - Combined reagent for treating mental and neurotic symptoms - Google Patents

Combined reagent for treating mental and neurotic symptoms Download PDF

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Publication number
CN105920553A
CN105920553A CN201610325557.1A CN201610325557A CN105920553A CN 105920553 A CN105920553 A CN 105920553A CN 201610325557 A CN201610325557 A CN 201610325557A CN 105920553 A CN105920553 A CN 105920553A
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parts
root
radix
rhizoma
psycho
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张旭东
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Abstract

The invention relates to a combined reagent for treating mental and neurotic symptoms. The combined reagent consists of the following substances in parts by weight: 10-30 parts of radix aconiti carmichaeli, 10-30 parts of fossil fragments, 10-30 parts of concha ostreae, 10-30 parts of dried ginger, 8-20 parts of radix glycyrrhizae preparata, 9-16 parts of cassia twig, 8-12 parts of wrinkled gianthyssop herb, 8-16 parts of cortex magnoliae officinalis, 10-18 parts of rhizoma pinelliae, 15-30 parts of poria, 15-30 parts of white atractylodes rhizome, 8-16 parts of rhizoma atractylodis, 15-20 parts of radix codonopsis, 12-20 parts of rhizoma seu radix notopterygii, 12-20 parts of radix bupleuri, 10-20 parts of rhizoma cyperi, 10-20 parts of radix curcumae, 12-30 parts of radix salviae miltiorrhizae, 12-20 parts of tortoise shell, 12-20 parts of cortex phellodendri, 12-20 parts of cortex moutan, 6-15 parts of fructus gardeniae, 8-15 parts of cortex cinnamomi, 8-15 parts of radix aucklandiae, 8-15 parts of fructus amomi and 8-15 parts of lignum santali albi. The medicine (the combined reagent) disclosed by the invention has a relatively high curative effect on depressive disorder, and the medicine is capable of treating both symptoms and root causes; the medicine is obvious in curative effect, free from adverse reaction and low in toxic and side effects; and the medicine is capable of rapidly curing clinical symptoms, without a phenomenon of recurrence.

Description

One treats psycho combination medicament
Technical field
The present invention relates to field of medicaments, relate in particular to one and treat psycho group Close medicament.
Background technology
Depression is also known as depressive disorder, low special for Major Clinical with notable and lasting mental state Levy, be the main Types of mental handicape.Mood downhearted can from depressed to extremely grieved, Feel oneself inferior depression, the most pessimistic and worldweary, can there be conamen or behavior；Even occur numb；Portion Point case has obvious anxiety；Severe patient may occur in which the psychotic symptoms such as illusion, vain hope.Often Even secondary outbreak continues more than 2 weeks, elder's several years, majority of cases has the tendency of recurrent exerbation, Depression is the common disease of serious harm human physical and mental health, frequently-occurring disease, and high-efficiency low-toxicity at present Medicament for treatment of depression the poorest, the therefore preventing and treating of depression and the development of new antidepressant Become one of current international the world of medicine forward position hot research problem.
Summary of the invention
It is an object of the invention to provide one and treat psycho combination medicament.
In order to realize the purpose of the present invention, the present invention provides one to treat psycho group Closing medicament, it comprises the material of following weight portion: monkshood 10-30 part, keel 10-30 part, Oyster 10-30 part, rhizoma zingiberis 10-30 part, honey-fried licorice root 8-20 part, cassia twig 9-16 part, wrinkled giant hyssop 8-12 part, bark of official magnolia 8-16 part, tuber of pinellia 10-18 part, Poria cocos 15-30 part, bighead atractylodes rhizome 15-30 part, Rhizoma atractylodis 8-16 part, Radix Codonopsis 15-20 part, notopterygium root 12-20 part, radix bupleuri 12-20 part, rhizoma cyperi 10-20 Part, root tuber of aromatic turmeric 10-20 part, red sage root 12-30 part, tortoise plastron 12-20 part, golden cypress 12-20 part, Root bark of tree peony 12-20 part, cape jasmine 6-15 part, Chinese cassia tree 8-15 part, banksia rose 8-15 part, fructus amomi 8-15 Part and santal 8-15 part.
Preferably, the psycho combination medicament for the treatment of of the present invention comprises following heavy Amount part material: monkshood 20 parts, keel 20 parts, oyster 20 parts, rhizoma zingiberis 20 parts, process sweet Grass 15 parts, cassia twig 12 parts, wrinkled giant hyssop 10 parts, the bark of official magnolia 12 parts, the tuber of pinellia 13 parts, Poria cocos 20 Part, the bighead atractylodes rhizome 20 parts, rhizoma atractylodis 13 parts, Radix Codonopsis 18 parts, notopterygium root 15 parts, radix bupleuri 15 parts, Rhizoma cyperi 15 parts, root tuber of aromatic turmeric 15 parts, the red sage root 20 parts, tortoise plastron 15 parts, golden cypress 15 parts, the root bark of tree peony 15 parts, cape jasmine 12 parts, Chinese cassia tree 12 parts, the banksia rose 12 parts, fructus amomi 12 parts and 12 parts of santal.
It is highly preferred that under the psycho combination medicament for the treatment of of the present invention also comprises The material of row weight portion: the material with following structural of 0.1 part:
Preferably, described combination medicament can be lotion, ointment or pulvis.
The present invention also provides for the material with following structural preparation treatment psychoneurosis disease Medicine in purposes:
The medicine of the present invention is higher for the curative effect of depression, treats both principal and secondary aspect of disease, evident in efficacy, nothing Bad reaction, toxic and side effect are little, and clinical symptom disappearance is rapid, without rebound phenomena after healing.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that the reality of the present invention Executing example is for illustrating rather than limitation of the present invention.Essence pair according to the present invention The simple modifications that the present invention is carried out broadly falls into the scope of protection of present invention.Unless otherwise saying Bright, otherwise the percentage in the present invention is percetage by weight.
Embodiment 1
Weigh monkshood 20 grams, keel 20 grams, oyster 20 grams, rhizoma zingiberis 20 grams, honey-fried licorice root 15 grams, cassia twig 12 grams, wrinkled giant hyssop 10 grams, the bark of official magnolia 12 grams, the tuber of pinellia 13 grams, 20 grams of Poria cocos, The bighead atractylodes rhizome 20 grams, rhizoma atractylodis 13 grams, Radix Codonopsis 18 grams, notopterygium root 15 grams, radix bupleuri 15 grams, rhizoma cyperi 15 grams, root tuber of aromatic turmeric 15 grams, the red sage root 20 grams, tortoise plastron 15 grams, golden cypress 15 grams, the root bark of tree peony 15 grams, Cape jasmine 12 grams, Chinese cassia tree 12 grams, the banksia rose 12 grams, fructus amomi 12 grams and 12 grams of santal, pulverize, Cross 100 mesh sieves and get final product.
Embodiment 2
Compound has a following structural:
Test example
Cleaning grade male mice in kunming 60, weight (20.0 ± 2.0) g.
Modelling and administration
Use chronic mild unpredictable stress stimulus add and lonely support (Xu Jing, Li Xiaoqiu. chronic stress The foundation of depression model and evaluation [j] thereof. Chinese hehavioral medical science, 2003.12 (1): 14-17.) Replicate depression mouse model, 5 groups of 50 mouse of remaining in addition to normal group are accepted 5 weeks with Machine stimulates, and including cold-wate swimming (4 DEG C, 5min), heat stress (45 DEG C, 5min), prohibits water (48 H), fasting (48h), folder tail (1min), confine, vola of shocking by electricity (current strength 1mA, every time Continue 10s, a minor tick 1min, 30 times altogether), overturn 24h round the clock, rock that (speed is 1 Secondary s-1, 15min), use a kind of stimulation every day, average every kind of stimulation is used 3 times, of the same race Stimulation can not occur continuously, makes animal can not expect the generation stimulated.In addition to control group, each group is little Mouse starts gastric infusion on the 3rd week from modeling, is administered and continues 21d, and administration time is every afternoon 5 Point, normal group and model group, give physiological saline gavage 1mL/500g body weight；Positive drug group, Fluoxetine hydrochloride 0.02g adds 1000mL normal saline and becomes suspension, gives gavage 1 ML/500g body weight；Administration group 1, the powder 1g of embodiment 1 adds 1000mL normal saline Become suspension, give gavage 1mL/500g body weight；Administration group 2, the compound of 0.02g adds 1000 ML normal saline becomes suspension, gives gavage 1mL/500g body weight；Administration group 3, real The compound of powder 0.5g with 0.01g executing example 1 adds 1000mL normal saline and becomes suspension, Give gavage 1mL/500g body weight.
Tail suspension test
36th afternoon carries out Tail suspension test after being administered 1h.By mouse tail away from end about At 2cm, it is pasted and fixed on a horizon bar with medical proof fabric and makes mouse hang by the feet in open top container, Head distance bottom 10cm, surrounding is isolated animal sight line with plate, is hung 6min, after record 4 When in min, mouse adds up motionless (mouse aloft stops struggle or the most tiny limb motion) Between be the disappointed time.Result see table.
Group The outstanding tail dead time (second)
Normal group 48.56±6.62
Model group 149.31±13.29*
Positive drug group 62.38±8.19*△
Administration group 1 90.08±11.62*△
Administration group 2 73.19±9.35*△
Administration group 3 82.39±10.42*△
Compare with normal group, * P < 0.05；Compare with model group,△P<0.05
Comparing with normal group, the outstanding tail dead time of model group and each treatment group significantly raises, Represent modeling success；Compare with model group, after treatment each treatment group hang the tail dead time substantially under Fall, illustrates to be respectively provided with result for the treatment of.

Claims (5)

1. treat psycho combination medicament for one kind, it is characterised in that under it comprises The material of row weight portion: monkshood 10-30 part, keel 10-30 part, oyster 10-30 part, dry Ginger 10-30 part, honey-fried licorice root 8-20 part, cassia twig 9-16 part, wrinkled giant hyssop 8-12 part, bark of official magnolia 8-16 Part, tuber of pinellia 10-18 part, Poria cocos 15-30 part, bighead atractylodes rhizome 15-30 part, rhizoma atractylodis 8-16 part, party Ginseng 15-20 part, notopterygium root 12-20 part, radix bupleuri 12-20 part, rhizoma cyperi 10-20 part, root tuber of aromatic turmeric 10-20 Part, red sage root 12-30 part, tortoise plastron 12-20 part, golden cypress 12-20 part, root bark of tree peony 12-20 part, Cape jasmine 6-15 part, Chinese cassia tree 8-15 part, banksia rose 8-15 part, fructus amomi 8-15 part and santal 8-15 Part.
The psycho combination medicament for the treatment of the most according to claim 1, it is special Levying and be, it comprises the material of following weight portion: monkshood 20 parts, keel 20 parts, oyster 20 parts, rhizoma zingiberis 20 parts, honey-fried licorice root 15 parts, cassia twig 12 parts, wrinkled giant hyssop 10 parts, the bark of official magnolia 12 Part, the tuber of pinellia 13 parts, 20 parts of Poria cocos, the bighead atractylodes rhizome 20 parts, rhizoma atractylodis 13 parts, Radix Codonopsis 18 parts, Notopterygium root 15 parts, radix bupleuri 15 parts, rhizoma cyperi 15 parts, root tuber of aromatic turmeric 15 parts, the red sage root 20 parts, tortoise plastron 15 parts, golden cypress 15 parts, the root bark of tree peony 15 parts, cape jasmine 12 parts, Chinese cassia tree 12 parts, the banksia rose 12 parts, Fructus amomi 12 parts and 12 parts of santal.
The psycho combination medicament for the treatment of the most according to claim 2, it is special Levying and be, it also comprises the material of following weight portion: the thing with following structural of 0.1 part Matter:
The psycho combination medicament for the treatment of the most according to claim 3, it is special Levying and be, described combination medicament can be lotion, ointment or pulvis.
5. there is the material of following structural in psycho medicine is treated in preparation Purposes:
CN201610325557.1A 2016-05-18 2016-05-18 Combined reagent for treating mental and neurotic symptoms Pending CN105920553A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111821412A (en) * 2019-04-19 2020-10-27 王旻霞 Traditional Chinese medicine composition for treating depression
CN114588243A (en) * 2021-05-11 2022-06-07 胡号应 Formula of two alternately taken traditional Chinese medicines for treating depression and anxiety

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105561282A (en) * 2016-03-08 2016-05-11 李荣山 Traditional Chinese medicine composition for curing depressive disorder

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105561282A (en) * 2016-03-08 2016-05-11 李荣山 Traditional Chinese medicine composition for curing depressive disorder

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111821412A (en) * 2019-04-19 2020-10-27 王旻霞 Traditional Chinese medicine composition for treating depression
CN114588243A (en) * 2021-05-11 2022-06-07 胡号应 Formula of two alternately taken traditional Chinese medicines for treating depression and anxiety
CN114588243B (en) * 2021-05-11 2024-01-05 胡号应 Two alternately taken Chinese medicinal formulas for treating depression and anxiety

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