CN105749148A - Traditional Chinese medicine combined extract with antifatigue effect as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine combined extract with antifatigue effect as well as preparation method and application thereof Download PDFInfo
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- CN105749148A CN105749148A CN201610118029.9A CN201610118029A CN105749148A CN 105749148 A CN105749148 A CN 105749148A CN 201610118029 A CN201610118029 A CN 201610118029A CN 105749148 A CN105749148 A CN 105749148A
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- 239000000284 extract Substances 0.000 title claims abstract description 59
- 230000000694 effects Effects 0.000 title claims abstract description 44
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 230000002929 anti-fatigue Effects 0.000 title abstract description 10
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 14
- 241000242759 Actiniaria Species 0.000 claims description 13
- 241000628997 Flos Species 0.000 claims description 13
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- 239000002994 raw material Substances 0.000 claims description 13
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- 238000001694 spray drying Methods 0.000 claims description 9
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 7
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Chemical & Material Sciences (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
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- Microbiology (AREA)
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Abstract
The invention discloses a traditional Chinese medicine combined extract with antifatigue effect as well as a preparation method and an application thereof and belongs to the technical field of traditional Chinese medicinal preparations. The traditional Chinese medicine combined extract with the antifatigue effect is prepared from salviae miltiorrhizae, ligusticum wallichii, kudzuvine root and earthworms in certain parts by weight. The traditional Chinese medicine combined extract with the antifatigue effect is scientific in compatibility and reasonable in preparation, experiments find that the traditional Chinese medicine combined extract or traditional Chinese medicine tablet thereof has good antifatigue effect, and traditional Chinese medicinal ingredients hardly produce side effect, so that the traditional Chinese medicine combined extract with the antifatigue effect is applicable to migrant workers as a health product to be taken in daily life and has a good market prospect.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, be specifically related to a kind of Chinese medicine composition extract with resisting fatigue effect and its preparation method and application.
Background technology
At present, along with socioeconomic developing rapidly, the raising of modernization of industry degree, the rhythm of life of people is substantially accelerated.The raising of industrialization degree will necessarily bring such as air and the negative effect such as pollution of waterhead aggravation, living environment deterioration, fatigue is the systemic reaction of a kind of physiology category, main manifestations is the reduction of tired sense of discomfort and ability to work, in general, the various physiological activities of human body have certain limit, once go beyond the limit, brain will send all tired signals, by requisite measures such as rest, sleeps, just can alleviate or allaying tiredness, thus avoiding into disease.In human lives, tired not entirely due to what the health overstrain such as physical work and sports caused, improvement along with contemporary work and physical qualification, the main cause that fatigue in people's muscle power is uncomfortable tired, due to the enhancing of the quickening of rhythm of life and time efficiency idea, modern is more mental fatigue, psychological fatigue and morbid state are tired, in a word, a large amount of sub-health populations occur therewith, the tired serious problems having become global concern.
Summary of the invention
It is an object of the invention to as solving the problems referred to above, it is provided that a kind of Chinese medicine composition extract with resisting fatigue effect.
The purpose of the present invention is realized by following technical proposals:
A kind of Chinese medicine composition extract with resisting fatigue effect, is made up of the raw material of following weight part ratio: Radix Salviae Miltiorrhizae 10-20 part, Rhizoma Chuanxiong 8-15 part, Radix Puerariae 8-15 part, Pheretima 8-15 part, Radix Paeoniae Rubra 8-12 part, Flos Carthami 6-10 part, Radix Curcumae 1 part, Radix Polygoni Multiflori Preparata 8-15 part, Rhizoma Alismatis 8-12 part, Fructus Lycii 8-15 part, Semen Ziziphi Spinosae 6-10 part, Radix Polygalae 6-12 part, Rhizoma Anemones Altaicae 8-15 part, Radix Achyranthis Bidentatae 8-12 part, Radix Glycyrrhizae 5-10 part.
Alternately, the Chinese medicine composition extract described in resisting fatigue effect is made up of the raw material of following weight part ratio: Radix Salviae Miltiorrhizae 14 parts, Rhizoma Chuanxiong 10 parts, Radix Puerariae 10 parts, Pheretima 10 parts, Radix Paeoniae Rubra 10 parts, 7 parts of Flos Carthami, Radix Curcumae 1 part, Radix Polygoni Multiflori Preparata 10 parts, Rhizoma Alismatis 10 parts, Fructus Lycii 10 parts, Semen Ziziphi Spinosae 7 parts, Radix Polygalae 10 parts, Rhizoma Anemones Altaicae 10 parts, Radix Achyranthis Bidentatae 10 parts, 7 parts of Radix Glycyrrhizae.
Alternately, the Chinese medicine composition extract described in resisting fatigue effect is made up of the raw material of following weight part ratio: Radix Salviae Miltiorrhizae 7-16 part, Rhizoma Chuanxiong 8-15 part, Radix Puerariae 6-13 part, Pheretima 7-12 part, Radix Paeoniae Rubra 8-12 part, Flos Carthami 5-9 part, Radix Curcumae 1-2 part, Radix Polygoni Multiflori Preparata 8-15 part, Rhizoma Alismatis 6-10 part, Fructus Lycii 9-16 part, Semen Ziziphi Spinosae 6-10 part, Radix Polygalae 6-12 part, Rhizoma Anemones Altaicae 8-15 part, Radix Achyranthis Bidentatae 6-10 part, Radix Glycyrrhizae 4-8 part, Semen Cuscutae 5-8 part, Radix Astragali 3-5 part, Radix Rehmanniae 7-10 part, Os Draconis 6-8 part.
Alternately, the Chinese medicine composition extract described in resisting fatigue effect is made up of the raw material of following weight part ratio: Radix Salviae Miltiorrhizae 13 parts, Rhizoma Chuanxiong 10 parts, Radix Puerariae 9 parts, Pheretima 8 parts, Radix Paeoniae Rubra 10 parts, 6 parts of Flos Carthami, Radix Curcumae 2 parts, Radix Polygoni Multiflori Preparata 10 parts, Rhizoma Alismatis 9 parts, Fructus Lycii 13 parts, Semen Ziziphi Spinosae 8 parts, Radix Polygalae 8 parts, Rhizoma Anemones Altaicae 10 parts, Radix Achyranthis Bidentatae 8 parts, 5 parts of Radix Glycyrrhizae, Semen Cuscutae 6 parts, the Radix Astragali 4 parts, Radix Rehmanniae 9 parts, Os Draconis 7 parts.
Present invention also offers a kind of described in there is the preparation method of Chinese medicine composition extract of resisting fatigue effect, it is characterised in that comprise the following steps:
(1) take each raw material respectively, clean, dry；
(2) each raw material after processing in step (1) is weighed by weight；
(3) load weighted Chinese medicine is added 8-12 times of water heating and refluxing extraction 2-3 time, each 1-2 hour, filter, merging filtrate, obtain the Chinese medicine composition extract with resisting fatigue effect.
Alternately, in above-mentioned preparation method, further comprising the steps of in described step (3): gained filtrate in step (3) is concentrated into the clear paste of relative density 1.10～1.15 (60 DEG C), and spray drying obtains extract extractum.
Present invention also offers a kind of Chinese medicinal tablet with resisting fatigue effect, it is characterised in that a kind of Chinese medicine composition extract with resisting fatigue effect of any of the above is the tablet that main active prepares.
Alternately, the described Chinese medicinal tablet with resisting fatigue effect includes the constituent of following percentage by weight: 1%-3% carboxymethylstach sodium, 9%-12% microcrystalline Cellulose, 4%-6% starch, 0.2%-0.5% magnesium stearate, surplus is a kind of Chinese medicine composition extract with resisting fatigue effect of any of the above.
Present invention also offers a kind of method preparing above-mentioned Chinese medicinal tablet: described Chinese medicine composition extract is concentrated into the clear paste of relative density 1.10～1.15 (60 DEG C), spray drying makes extract extractum, then each component materials dry powder is sufficiently mixed, dry granulation, cross 80 mesh sieves, control every tablet weight 0.42g tabletting, bag veneer coated tablet and get final product.
Present invention also offers the application in preparation fatigue alleviating health product or medicine of a kind of described Chinese medicine composition extract or Chinese medicinal tablet.
All features disclosed in this specification, or the step in disclosed all methods or process, except mutually exclusive feature and/or step, all can combine by any way.
Beneficial effects of the present invention:
Compatibility science of the present invention, preparation rationally, finds described Chinese medicine composition extract or its Chinese medicinal tablet through experiment, has good resisting fatigue effect, and Chinese medicine ingredients is substantially without having side effects simultaneously.It is suitable for young migrants seeking job in cities to take in daily life as health product, there is good market prospect.
Detailed description of the invention
By the following examples the present invention is specifically described; be necessary it is pointed out here that be that the present embodiment is served only for the present invention is further described; but it is not intended that limiting the scope of the invention, the present invention can be made improvement and the adjustment of some non-intrinsically safes by the person skilled in the art in this field according to the content of the invention described above.
Embodiment 1:
Take Radix Salviae Miltiorrhizae 140g, Rhizoma Chuanxiong 100g, Radix Puerariae 100g, Pheretima 100g, Radix Paeoniae Rubra 100g, Flos Carthami 70g, Radix Curcumae 10g, Radix Polygoni Multiflori Preparata 100g, Rhizoma Alismatis 100g, Fructus Lycii 100g, Semen Ziziphi Spinosae 70g, Radix Polygalae 100g, Rhizoma Anemones Altaicae 100g, Radix Achyranthis Bidentatae 100g, Radix Glycyrrhizae 70g.Load weighted Chinese medicine is added 10 times of water heating and refluxing extraction 3 times, each 1 hour, filter, merging filtrate, obtain the Chinese medicine composition extract with resisting fatigue effect；Gained filtrate is concentrated into the clear paste of relative density 1.10 (60 DEG C), and spray drying obtains extract extractum；Forming according to following percentage by weight: 2% carboxymethylstach sodium, 10% microcrystalline Cellulose, 5% starch, 0.5% magnesium stearate, surplus is extract extractum.Above-mentioned substance dry powder is sufficiently mixed, dry granulation, crosses 80 mesh sieves, control every tablet weight 0.42g tabletting, bag veneer coated tablet and get final product.
Embodiment 2:
To Expermental research on main pharmacodynamics such as mouse anti-reflecting fatigues.
1. mice fatigue turn-club test
Experiment tablet: the tablet of preparation in embodiment 1,0.42g every (is equivalent to crude drug amount and is about 0.6g).
Cleaning grade kunming mice, male and female half and half, body weight 18-22g, animal sub-cage rearing, keeps 12h circadian rhythm, room temperature 24 ± 1 DEG C, freely drink water and ingest, mice is randomly divided into five groups, often group 10, male and female half and half, it is respectively as follows: blank group (normal saline, 0.1ml/kg, i.g.), experiment slice agent dose group, every treated animal successive administration 7 days.
According to raw medicine calculation, every day, the consumption of 70kg people was 5.4g, every tablet 0.42g is containing about crude drug amount 0.6g, namely daily requirement divide 3 times each 3 take, therefore the consumption of dosage mice of often merely hitting every day is: 5.4*10/70=0.777g/kg crude drug amount, according to the raw medicine calculation of 0.8g/kg, namely dosage mice in, the tablet dose of every day every is 0.75g/kg, separately, high low dose group dosage respectively 2.0g/kg and 0.25g/kg tablet is set, fluoxetine and experiment tablet are administered volume according to dosage and 0.1ml/10g, every mice administration range is between 0.2ml～0.8ml, with physiological saline solution, it is configured to the solution of appropriate concentration.
Once a day, continuous 7 days.Often group mice is individually placed on transfer rod, makes muscle be in the state that static(al) is nervous.The speed regulating transfer rod is 20rpm/min, records each group of mice owing to muscle fatigue is from the time fallen Glass rod, and training 2 times before experiment start timing the 3rd time, terminate experiment when falling, and the time of the 3rd time is as the mice pole-climbing time, and record.Result is in Table 1.
Table 1 various dose experiment tablet is on the mice impact at tired rotating stick test
* with blank group than P < 0.05, * * with blank group than < 0.01
From table 1, in experiment tablet, there is the difference of significance the high dose group test mice time of staying on transfer rod compared with blank group, and this illustrates that Chinese medicine composition extract can extend the mice fatigue time, namely illustrates have certain antifatigue effect.
2. Endurance runs experiment
Experiment tablet: the tablet of preparation in embodiment 1,0.42g every (is equivalent to crude drug amount and is about 0.6g).
Cleaning grade kunming mice, male and female half and half, body weight 18-22g, animal sub-cage rearing, keeps 12h circadian rhythm, room temperature 24 ± 1 DEG C, freely drink water and ingest, mice is randomly divided into five groups, often group 10, male and female half and half, it is respectively as follows: blank group (normal saline, 0.1ml/kg, i.g.), experiment slice agent dose group, every treated animal successive administration 7 days.
According to raw medicine calculation, every day, the consumption of 70kg people was 5.4g, every tablet 0.42g is containing about crude drug amount 0.6g, namely daily requirement divide 3 times each 3 take, therefore the consumption of dosage mice of often merely hitting every day is: 5.4*10/70=0.777g/kg crude drug amount, according to the raw medicine calculation of 0.8g/kg, namely dosage mice in, the tablet dose of every day every is 0.75g/kg, separately, high low dose group dosage respectively 2.0g/kg and 0.25g/kg tablet is set, fluoxetine and experiment tablet are administered volume according to dosage and 0.1ml/10g, every mice administration range is between 0.2ml～0.8ml, with physiological saline solution, it is configured to the solution of appropriate concentration.
Once a day, continuous 7 days.After last is administered 1 hour, often group mice is individually placed on mice treadmill, first places animal, mice is trained 1min so that it is understand after fleeing from charging zone, rotating speed is set to 20rpm, electric current is transferred to 30A, records the number of times that in each dosage group 4min, mice is electrically shocked.Result is in Table 2.
The experiment tablet impact on mice number of shocks of table 2 various dose
| Group | Number of shocks (n) |
| Blank group | 44.15±5.69 |
| Low dose group | 50.54±7.61 |
| Middle dosage group | 35.48±5.04 |
| High dose group | 25.11±3.79* |
* with blank group than P < 0.05, * * with blank group than < 0.01
From table 2, low middle dosage group there was no significant difference with the contrast of blank group, and high dose group has general significant difference with the contrast of blank group, and in general, experiment tablet can strengthen the anti-fatigue ability of mice.
3. mice burden swimming experiment
Experiment tablet: the tablet of preparation in embodiment 1,0.42g every (is equivalent to crude drug amount and is about 0.6g).
Cleaning grade kunming mice, male and female half and half, body weight 18-22g, animal sub-cage rearing, keeps 12h circadian rhythm, room temperature 24 ± 1 DEG C, freely drink water and ingest, mice is randomly divided into five groups, often group 10, male and female half and half, it is respectively as follows: blank group (normal saline, 0.1ml/kg, i.g.), experiment slice agent dose group, every treated animal successive administration 7 days.
According to raw medicine calculation, every day, the consumption of 70kg people was 5.4g, every tablet 0.42g is containing about crude drug amount 0.6g, namely daily requirement divide 3 times each 3 take, therefore the consumption of dosage mice of often merely hitting every day is: 5.4*10/70=0.777g/kg crude drug amount, according to the raw medicine calculation of 0.8g/kg, namely dosage mice in, the tablet dose of every day every is 0.75g/kg, separately, high low dose group dosage respectively 2.0g/kg and 0.25g/kg tablet is set, fluoxetine and experiment tablet are administered volume according to dosage and 0.1ml/10g, every mice administration range is between 0.2ml～0.8ml, with physiological saline solution, it is configured to the solution of appropriate concentration.
Once a day, continuous 7 days.After last is administered 1 hour, tying up at mouse tail is placed in swimming with a load attached to the body tester by each dosage group and naive mice with lead button (weight ratio 1: 10 of lead button and Mouse Weight) successively, depth of water 25cm, water temperature 25 ± 2 DEG C, measure the time that each group of mice swimming power exhausts record.Result is in Table 3.
The experiment tablet impact on mice burden swimming of table 3 various dose
| Group | Power exhausts the time (s) |
| Blank group | 151.67±19.34 |
| Low dose group | 179.29±20.69 |
| Middle dosage group | 198.47±17.68* |
| High dose group | 235.45±26.31** |
* with blank group than P < 0.05, * * with blank group than < 0.01
From table 3, low dose group there was no significant difference with the contrast of blank group, and middle dosage group has general significant difference compared with blank group, and high dose group has good significant difference with the contrast of blank group, in general, the resistance to anti-fatigue ability of mice can be produced certain potentiation by experiment tablet.
In above-mentioned each experiment, described experiment tablet is changed into embodiment 1 is prepared Chinese medicine composition extract (extract doses calculates by the extract actual dose contained corresponding in described experiment slice agent dose), the result basically identical with above-mentioned experimental result can be obtained, it was demonstrated that described Chinese medicine composition extract has anti-fatigue effect.
Embodiment 3:
Take Radix Salviae Miltiorrhizae 100g, Rhizoma Chuanxiong 150g, Radix Puerariae 80g, Pheretima 80g, Radix Paeoniae Rubra 120g, Flos Carthami 100g, Radix Curcumae 10g, Radix Polygoni Multiflori Preparata 150g, Rhizoma Alismatis 80g, Fructus Lycii 80g, Semen Ziziphi Spinosae 100g, Radix Polygalae 60g, Rhizoma Anemones Altaicae 150g, Radix Achyranthis Bidentatae 80g, Radix Glycyrrhizae 100g.Load weighted Chinese medicine is added 12 times of water heating and refluxing extraction 3 times, each 1.5 hours, filter, merging filtrate, obtain the Chinese medicine composition extract with resisting fatigue effect；Gained filtrate is concentrated into the clear paste of relative density 1.15 (60 DEG C), and spray drying obtains extract extractum；Forming according to following percentage by weight: 3% carboxymethylstach sodium, 9% microcrystalline Cellulose, 6% starch, 0.3% magnesium stearate, surplus is extract extractum.Above-mentioned substance dry powder is sufficiently mixed, dry granulation, crosses 80 mesh sieves, control every tablet weight 0.42g tabletting, bag veneer coated tablet and get final product.
Embodiment 4:
Take Radix Salviae Miltiorrhizae 200g, Rhizoma Chuanxiong 80g, Radix Puerariae 150g, Pheretima 150g, Radix Paeoniae Rubra 80g, Flos Carthami 60g, Radix Curcumae 10g, Radix Polygoni Multiflori Preparata 80g, Rhizoma Alismatis 120g, Fructus Lycii 150g, Semen Ziziphi Spinosae 60g, Radix Polygalae 120g, Rhizoma Anemones Altaicae 80g, Radix Achyranthis Bidentatae 120g, Radix Glycyrrhizae 50g.Load weighted Chinese medicine is added 8 times of water heating and refluxing extraction 2 times, each 2 hours, filter, merging filtrate, obtain the Chinese medicine composition extract with resisting fatigue effect；Gained filtrate is concentrated into the clear paste of relative density 1.12 (60 DEG C), and spray drying obtains extract extractum；Forming according to following percentage by weight: 1% carboxymethylstach sodium, 12% microcrystalline Cellulose, 4% starch, 0.2% magnesium stearate, surplus is extract extractum.Above-mentioned substance dry powder is sufficiently mixed, dry granulation, crosses 80 mesh sieves, control every tablet weight 0.42g tabletting, bag veneer coated tablet and get final product.
Embodiment 5:
Take Radix Salviae Miltiorrhizae 130g, Rhizoma Chuanxiong 100g, Radix Puerariae 90g, Pheretima 80g, Radix Paeoniae Rubra 100g, Flos Carthami 60g, Radix Curcumae 20g, Radix Polygoni Multiflori Preparata 100g, Rhizoma Alismatis 90g, Fructus Lycii 130g, Semen Ziziphi Spinosae 80g, Radix Polygalae 80g, Rhizoma Anemones Altaicae 100g, Radix Achyranthis Bidentatae 80g, Radix Glycyrrhizae 50g, Semen Cuscutae 60g, Radix Astragali 40g, Radix Rehmanniae 90g, Os Draconis 70g.Load weighted Chinese medicine is added 10 times of water heating and refluxing extraction 3 times, each 1 hour, filter, merging filtrate；Gained filtrate is concentrated into the clear paste of relative density 1.10 (60 DEG C), and spray drying obtains extract extractum；Forming according to following percentage by weight: 2% carboxymethylstach sodium, 10% microcrystalline Cellulose, 5% starch, 0.5% magnesium stearate, surplus is extract extractum.Above-mentioned substance dry powder is sufficiently mixed, dry granulation, crosses 80 mesh sieves, control every tablet weight 0.42g tabletting, bag veneer coated tablet and get final product.
Embodiment 6:
Each raw material is all through cleaning, and after drying, takes Radix Salviae Miltiorrhizae 7-16 part, Rhizoma Chuanxiong 8-15 part by weight, Radix Puerariae 6-13 part, Pheretima 7-12 part, Radix Paeoniae Rubra 8-12 part, Flos Carthami 5-9 part, Radix Curcumae 1-2 part, Radix Polygoni Multiflori Preparata 8-15 part, Rhizoma Alismatis 6-10 part, Fructus Lycii 9-16 part, Semen Ziziphi Spinosae 6-10 part, Radix Polygalae 6-12 part, Rhizoma Anemones Altaicae 8-15 part, Radix Achyranthis Bidentatae 6-10 part, Radix Glycyrrhizae 4-8 part, Semen Cuscutae 5-8 part, Radix Astragali 3-5 part, Radix Rehmanniae 7-10 part, Os Draconis 6-8 part.Load weighted Chinese medicine is added 8-12 times of water heating and refluxing extraction 2-3 time, each 1-2 hour, filter, merging filtrate, obtain the Chinese medicine composition extract with resisting fatigue effect；Gained filtrate is concentrated into the clear paste of relative density 1.10～1.15 (60 DEG C), and spray drying obtains extract extractum；Forming according to following percentage by weight: 1%-3% carboxymethylstach sodium, 9%-12% microcrystalline Cellulose, 4%-6% starch, 0.2%-0.5% magnesium stearate, surplus is extract extractum.Above-mentioned substance dry powder is sufficiently mixed, dry granulation, crosses 80 mesh sieves, control every tablet weight 0.42g tabletting, bag veneer coated tablet and get final product.
Embodiment 7:
With reference to the experimental technique described in embodiment 2, respectively group Chinese medicine composition extract and the tablet thereof of preparation in embodiment 3-6 are carried out Expermental research on main pharmacodynamics.Result shows: in embodiment 3 and 4, the Chinese medicine composition extract of gained and tablet thereof are suitable with the Chinese medicine composition extract of preparation in embodiment 1 and the effect of tablet thereof to the resisting fatigue effect of mice, all demonstrate obvious resisting fatigue effect, and the Chinese medicine composition extract prepared in embodiment 5 and 6 and the tablet resisting fatigue effect more excellent than the Chinese medicine composition extract prepared in embodiment 1 and tablet thereof (difference of statistical analysis display experimental data has statistical significance) to mice thereof, the Chinese medicine composition extract wherein prepared in embodiment 5 and the resisting fatigue best results of tablet thereof.
The foregoing is only the preferred embodiments of the present invention, be merely illustrative for the purpose of the present invention, and nonrestrictive；Those of ordinary skill in the art understand, and it can be carried out many changes in the spirit and scope that the present invention limits, amendment, and even equivalence is changed, but falls within protection scope of the present invention.
Claims (10)
1. a Chinese medicine composition extract with resisting fatigue effect, it is characterised in that be made up of the raw material of following weight part ratio: Radix Salviae Miltiorrhizae 10-20 part, Rhizoma Chuanxiong 8-15 part, Radix Puerariae 8-15 part, Pheretima 8-15 part, Radix Paeoniae Rubra 8-12 part, Flos Carthami 6-10 part, Radix Curcumae 1 part, Radix Polygoni Multiflori Preparata 8-15 part, Rhizoma Alismatis 8-12 part, Fructus Lycii 8-15 part, Semen Ziziphi Spinosae 6-10 part, Radix Polygalae 6-12 part, Rhizoma Anemones Altaicae 8-15 part, Radix Achyranthis Bidentatae 8-12 part, Radix Glycyrrhizae 5-10 part.
2. the Chinese medicine composition extract with resisting fatigue effect according to claim 1, it is characterised in that be made up of the raw material of following weight part ratio: Radix Salviae Miltiorrhizae 14 parts, Rhizoma Chuanxiong 10 parts, Radix Puerariae 10 parts, Pheretima 10 parts, Radix Paeoniae Rubra 10 parts, 7 parts of Flos Carthami, Radix Curcumae 1 part, Radix Polygoni Multiflori Preparata 10 parts, Rhizoma Alismatis 10 parts, Fructus Lycii 10 parts, Semen Ziziphi Spinosae 7 parts, Radix Polygalae 10 parts, Rhizoma Anemones Altaicae 10 parts, Radix Achyranthis Bidentatae 10 parts, 7 parts of Radix Glycyrrhizae.
3. the Chinese medicine composition extract with resisting fatigue effect according to claim 1, it is characterised in that be made up of the raw material of following weight part ratio: Radix Salviae Miltiorrhizae 7-16 part, Rhizoma Chuanxiong 8-15 part, Radix Puerariae 6-13 part, Pheretima 7-12 part, Radix Paeoniae Rubra 8-12 part, Flos Carthami 5-9 part, Radix Curcumae 1-2 part, Radix Polygoni Multiflori Preparata 8-15 part, Rhizoma Alismatis 6-10 part, Fructus Lycii 9-16 part, Semen Ziziphi Spinosae 6-10 part, Radix Polygalae 6-12 part, Rhizoma Anemones Altaicae 8-15 part, Radix Achyranthis Bidentatae 6-10 part, Radix Glycyrrhizae 4-8 part, Semen Cuscutae 5-8 part, Radix Astragali 3-5 part, Radix Rehmanniae 7-10 part, Os Draconis 6-8 part.
4. the Chinese medicine composition extract with resisting fatigue effect according to claim 1, it is characterised in that be made up of the raw material of following weight part ratio: Radix Salviae Miltiorrhizae 13 parts, Rhizoma Chuanxiong 10 parts, Radix Puerariae 9 parts, Pheretima 8 parts, Radix Paeoniae Rubra 10 parts, 6 parts of Flos Carthami, Radix Curcumae 2 parts, Radix Polygoni Multiflori Preparata 10 parts, Rhizoma Alismatis 9 parts, Fructus Lycii 13 parts, Semen Ziziphi Spinosae 8 parts, Radix Polygalae 8 parts, Rhizoma Anemones Altaicae 10 parts, Radix Achyranthis Bidentatae 8 parts, 5 parts of Radix Glycyrrhizae, Semen Cuscutae 6 parts, the Radix Astragali 4 parts, Radix Rehmanniae 9 parts, Os Draconis 7 parts.
5. a Chinese medicinal tablet with resisting fatigue effect, it is characterised in that the tablet that the Chinese medicine composition extract with resisting fatigue effect any one of in claim 1-4 prepares for main active.
6. the Chinese medicinal tablet with resisting fatigue effect according to claim 5, it is characterized in that, constituent including following percentage by weight: 1%-3% carboxymethylstach sodium, 9%-12% microcrystalline Cellulose, 4%-6% starch, 0.2%-0.5% magnesium stearate, surplus is the Chinese medicine composition extract with resisting fatigue effect any one of in claim 1-4.
7. the preparation method according to the Chinese medicine composition extract with resisting fatigue effect any one of in claim 1-4, it is characterised in that comprise the following steps:
(1) take each raw material respectively, clean, dry；
(2) each raw material after processing in step (1) is weighed by weight；
(3) load weighted Chinese medicine is added 8-12 times of water heating and refluxing extraction 2-3 time, each 1-2 hour, filter, merging filtrate, obtain the Chinese medicine composition extract with resisting fatigue effect.
8. preparation method according to claim 7, it is characterized in that, further comprising the steps of in described step (3): gained filtrate in step (3) is concentrated into the clear paste of relative density 1.10～1.15 (60 DEG C), and spray drying obtains extract extractum.
9. the preparation method of the Chinese medicinal tablet with resisting fatigue effect according to claim 5, it is characterized in that, described Chinese medicine composition extract is concentrated into the clear paste of relative density 1.10～1.15 (60 DEG C), spray drying makes extract extractum, then each component materials dry powder is sufficiently mixed, dry granulation, crosses 80 mesh sieves, control every tablet weight 0.42g tabletting, bag veneer coated tablet and get final product.
10. the Chinese medicine composition extract as described in claim 1-4 or the application in preparation fatigue alleviating health product or medicine of the Chinese medicinal tablet as described in claim 5.
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