CN106822733A - A kind of paste and preparation method for treating precancerous lesions of chronic atrophic gastritis - Google Patents
A kind of paste and preparation method for treating precancerous lesions of chronic atrophic gastritis Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/902—Sparganiaceae (Bur-reed family)
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- A61K36/906—Zingiberaceae (Ginger family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a kind of paste for treating precancerous lesions of chronic atrophic gastritis, it is made up of following bulk drug：28~32g of the Radix Astragali, 16~20g of Sculellaria barbata, 28~32g of coix seed, 5~8g of stir-baked RHIZOMA SPARGANII with vinegar, 8~10g of the root of Dahurain angelica, 5~8g of kaempferia galamga, 5~8g of edible tulip, 10~15g of rhodiola root, 2~4g of Chinese cassia tree, 2~4g of borneol.The paste for the treatment of precancerous lesions of chronic atrophic gastritis of the invention, during treatment, using the method (sticking the middle part of gastric cavity, Zusanli, spleen acupoint, stomach acupuncture points on the human body) of point-application, can obviously improve patient's gastric mucosal lesion and pathology, the diseases such as gastral cavity pain, gastral cavilty feeling of fullness, indigestion and loss of appetite weak, gastric upset and eructation can be effectively improved, patients ' life quality is favorably improved, therapeutic effect is substantially better than stilbene lotus and relaxes ruffian particle, the stomach multiple spring, there is significant difference (P ＜ 0.05).
Description
Technical field
The present invention relates to a kind of paste and preparation method for treating precancerous lesions of chronic atrophic gastritis.
Background technology
Atrophic gastritis (ChronicAtrophicGastritis, CAG) is digestive system common disease, frequently-occurring disease,
Because itself and stomach cancer have certain relation .1978 WHO to be classified as disease or precancerous condition before the cancer of stomach cancer.Stomach cancer is most
Common malignant tumour, serious harm human health.And stomach lining cancerous swelling is not to become cancer cell by normal cell " jump ", and
A process for multi-step canceration, i.e. chronic superficial gastritis → atrophic gastritis → intestinal metaplasia → dysplasia → stomach
Cancer, the lesion for occurring in the meantime referred to as precancerous lesion.Precancerous lesion refers to the stomach lining pathology that a class is susceptible to canceration
The dysplasia of histological change, i.e. stomach lining and intestinal metaplasia, it is main with atrophic gastritis is stored in, so clinically
Often being referred to as precancerous lesions of chronic atrophic gastritis or stomach cercinoma prophase pathologic change with intestinal metaplasia, dysplasia, with moderate with
On dysplasia and not exclusively big visible peristalsis visible intestinal peristalsis metaplasia be then referred to as real preventing precancerous lesion of stomach cancer.
At present, in terms of precancerous lesions of chronic atrophic gastritis is treated, using elimination helicobacter pylori (HP) sense more than doctor trained in Western medicine
Dye, improves WeiDongLi Capsule, protects stomach lining, Supplement of folic acid, B family vitamin etc. for its cause of disease treatment method, or under scope it is micro-
Wound treatment, but lack the medicine and preferable treatment method of curative effect affirmative.Though traditional Chinese medicine is evident in efficacy, oral traditional Chinese medicine
(or exempt from decoct particle) more or less exist it is inconvenient to carry, decoct take after mixing it with water tasty trouble, medicament, the difficult control of quality, the difficult control of expense, suffer from
The problems such as person's compliance difference, and have the oral Chinese patent medicine of definite curative effect few.Therefore, determined curative effect, a letter are sought
The treatment method of easy row is imperative.
The content of the invention
For above-mentioned prior art, the invention provides a kind of paste for treating precancerous lesions of chronic atrophic gastritis, and
Its preparation method.
The present invention is achieved by the following technical solutions：
A kind of paste for treating precancerous lesions of chronic atrophic gastritis, is made up of following bulk drug：The Radix Astragali 28~
32g, 16~20g of Sculellaria barbata, 28~32g of coix seed, 5~8g of stir-baked RHIZOMA SPARGANII with vinegar, 8~10g of the root of Dahurain angelica, 5~8g of kaempferia galamga, 5~8g of edible tulip,
10~15g of rhodiola root, 2~4g of Chinese cassia tree, 2~4g of borneol.
Preferably, it is made up of following bulk drug：Radix Astragali 30g, Sculellaria barbata 18g, coix seed 30g, stir-baked RHIZOMA SPARGANII with vinegar 6g, the root of Dahurain angelica
9g, kaempferia galamga 6g, edible tulip 6g, rhodiola root 12g, Chinese cassia tree 6g, borneol 3g.
The preparation method of the paste of the treatment precancerous lesions of chronic atrophic gastritis, comprises the following steps：
(1) Radix Astragali, Sculellaria barbata and rhodiola root, plus 8 times of 50% ethanol solution (volumes hundred of amount (weight multiple, similarly hereinafter) are taken
Fraction, similarly hereinafter), heating and refluxing extraction 2 times 1.5 hours every time, merges extract solution, and filtering, 50~60 DEG C of filtrate is recovered under reduced pressure second
Alcohol, (thick paste, water content is 15%~20%, and per 1g equivalent to 2~5g of crude drug, this is public this area to be condensed into thick paste
Know general knowledge, will not be repeated here)；
Coix seed, the root of Dahurain angelica and edible tulip, plus 8 times of 80% ethanol solutions of amount, heating and refluxing extraction 2 times are taken, 1.5 is small every time
When, merging extract solution, filtering, 50~60 DEG C of filtrate is recovered under reduced pressure ethanol, is condensed into thick paste；
Stir-baked RHIZOMA SPARGANII with vinegar and kaempferia galamga are taken, coarse granule, plus 10 times of water of amount are ground into, soaked 0.5 hour, extracted, collect volatile oil
(being extracted by volatile oil extracting method, be conventional method), extract solution filtering, is concentrated into relative density 1.05, is cooled to room temperature,
Plus ethanol or ethanol solution make alcohol content to 70%, 4 DEG C of refrigeration 24h, filtering, 50~60 DEG C of filtrate is recovered under reduced pressure ethanol, concentrates
Into thick paste, the volatile oil of foregoing collection is added, mixed, obtain thick paste, it is standby；
Chinese cassia tree is taken, fine powder (120 mesh) is ground into, Chinese cassia tree powder is obtained；
Borneol, plus a small amount of ethanol grinding dissolving are taken, Chinese cassia tree powder is added, mixed, add three kinds of thick pastes obtained above (to contain
Volatile oil), mix, drug extract is obtained, it is standby；
(2) drug extract obtained above is added into matrix, is made gel emplastrum (cataplasm).
Further, the specific method of the step (2) is (each component is by weight)：Ionized water (70 parts) is removed,
Disodium ethylene diamine tetraacetate a little (0.001~0.003 part) and Tween-80 (0.01~0.03 part) are added, is mixed, low speed is stirred
Mix (60~90 revs/min), add Carbomer-940 resin (2 parts), moderate-speed mixer (200~400 revs/min) to divide 3~5 batches
The resin of Carbomer -941 (15 parts) is added, stirring at low speed pours into kneader in 2 hours to uniform, and regulation temperature is 50 DEG C, stirring 2
Hour, vacuumize, stir, stand, obtain bare substrate；
Stirring at low speed bare substrate, regulation pH value to 5~7 (is slowly added to the NaOH solution that mass fraction is 10% to adjust
Section), while being slowly added to glycerine, (addition is the 15%~23% of bare substrate volume, preferably 22.67%), is mixed, and must be contained
The bare substrate of glycerine；
Drug extract is suspended in 3 times of 95% ethanol solutions of volume, is slowly added under the conditions of stirring at low speed
In above-mentioned glycerinated bare substrate (after addition, drug extract account for gross weight 1%~5%), dispersed with stirring is uniform, while hot
It is coated on non-woven fabrics, is cooled to room temperature cutting blocking.
The traditional Chinese medical science thinks, precancerous lesions of chronic atrophic gastritis is so that taste are deficient, deficiency of both qi and yin for this, it is qi and blood stasis, damp and hot
It is mark to pent up., in stomach, pathology is centered on spleen kidney deficiency damage for diseased region.Accordingly, the present invention establishes tonifying speen and tonifying kidney, promoting the circulation of qi
The stasis of blood, clearing away heat and eliminating dampeness, the therapy of powder detoxifcation.Select the gas of the kind tonifying spleen and stomach of the Radix Astragali, myogenic blood-nourishing in side.Sculellaria barbata be apt to it is clearing heat and detoxicating, it is cool
Blood dissipates the stasis of blood, and can anticancer analgetic.Coix seed invigorating spleen for diuresis excreting dampness, detoxicating and resolving a mass.Root of Dahurain angelica wind-damp dispelling, apocenosis of invigorating blood circulation, myogenic pain relieving.
Stir-baked RHIZOMA SPARGANII with vinegar regulating qi to disperse stagnation, promoting qi circulation and relieving pain, disperse accumulations.Kaempferia galamga promoting the circulation of qi middle benefit gas, analgesic.Edible tulip is clearing heat and detoxicating, reducing phlegm and resolving masses.Rhodiola root
Tonifying Qi nourishing heart, controlling of bleeding with astringents, eliminating stasis to subdue swelling, Chinese cassia tree complement sun, warming spleen and stomach, removing internal cold, promoting blood circulation.Borneol is clearing heat and detoxicating, anti-corrosion
Myogenic.All medicines share, plays the work(of strengthening spleen, tonifying kidney, benefiting qi for promoting granulation, regulating qi to disperse stagnation, clearing away heat and eliminating dampeness, detoxicating and resolving a mass altogether.
The paste for the treatment of precancerous lesions of chronic atrophic gastritis of the invention, for treating atrophic gastritis precancerosis
Become, during treatment, using the method (sticking the middle part of gastric cavity, Zusanli, spleen acupoint, stomach acupuncture points on the human body) of point-application, pass through medicine directly subcutaneous
Absorb and indirect stimulation excites acupuncture point that therapeutic action is played through the approach of gas, can obviously improve patient's gastric mucosal lesion and disease
Reason, can be effectively improved the diseases such as gastral cavity pain, gastral cavilty feeling of fullness, indigestion and loss of appetite weak, gastric upset and eructation, be favorably improved patients ' life quality.
Paste of the invention, is improving patient's gastric mucosal lesion and pathology, alleviates the aspects such as gastral cavity pain, gastral cavilty feeling of fullness, gastric upset and eructation
Better than the easypro ruffian particle of stilbene lotus, there is significant difference (P ＜ 0.05).In terms of comprehensive therapeutic effect, and improve patient's gastric mucosa disease
Become and pathology, alleviate the aspects such as gastral cavity pain, gastral cavilty feeling of fullness, gastric upset and eructation better than the stomach multiple spring, there is significant difference (P ＜
0.05)。
Specific embodiment
With reference to embodiment, the present invention is further illustrated.
Embodiment 1 prepares the paste for the treatment of precancerous lesions of chronic atrophic gastritis
Prescription is：Radix Astragali 30g, Sculellaria barbata 18g, coix seed 30g, stir-baked RHIZOMA SPARGANII with vinegar 6g, root of Dahurain angelica 9g, kaempferia galamga 6g, edible tulip 6g are red
Red-spotted stonecrop 12g, Chinese cassia tree 6g, borneol 3g.
Step is as follows：
(1) Radix Astragali, Sculellaria barbata and rhodiola root are taken, plus 8 times of 50% ethanol solutions of amount, heating and refluxing extraction 2 times, every time
1.5 hours, merge extract solution, filtering, 50~60 DEG C of filtrate is recovered under reduced pressure ethanol, is condensed into thick paste；
Coix seed, the root of Dahurain angelica and edible tulip, plus 8 times of 80% ethanol solutions of amount, heating and refluxing extraction 2 times are taken, 1.5 is small every time
When, merging extract solution, filtering, 50~60 DEG C of filtrate is recovered under reduced pressure ethanol, is condensed into thick paste；
Stir-baked RHIZOMA SPARGANII with vinegar and kaempferia galamga are taken, coarse granule, plus 10 times of water of amount are ground into, soaked 0.5 hour, extracted, collect volatile oil,
Extract solution is filtered, and is concentrated into relative density 1.05, is cooled to room temperature, plus ethanol or ethanol solution make alcohol content to 70%, and 4 DEG C cold
24h is hidden, filtering, 50~60 DEG C of filtrate is recovered under reduced pressure ethanol, is condensed into thick paste, adds the volatile oil of foregoing collection, mixes, and obtains thick
Cream, it is standby；
Chinese cassia tree is taken, fine powder (120 mesh) is ground into, Chinese cassia tree powder is obtained；
Borneol, plus a small amount of ethanol grinding dissolving are taken, Chinese cassia tree powder is added, mixed, add three kinds of thick pastes obtained above (to contain
Volatile oil), mix, drug extract is obtained, it is standby；
(2) drug extract obtained above is added into matrix, is made gel emplastrum (cataplasm)：Remove ionized water 70
Part, 0.002 part and 0.012 part of Tween-80 of disodium ethylene diamine tetraacetate is added, mix, stirring at low speed (80 revs/min), plus
Enter 2 parts of Carbomer-940 resin, moderate-speed mixer (300 revs/min), point 4 batches of 15 parts of addition Carbomer -941 resins, stirring at low speed
To uniform, kneader is poured within 2 hours, regulation temperature is 50 DEG C, is stirred 2 hours, is vacuumized, and is stirred, and is stood, and obtains blank base
Matter；
Stirring at low speed bare substrate, regulation pH value to 6 (is slowly added to the NaOH solution regulation that mass fraction is 10%), together
When be slowly added to glycerine the 22.67% of bare substrate volume (addition for), mix, obtain glycerinated bare substrate；
Drug extract is suspended in 3 times of 95% ethanol solutions of volume, is slowly added under the conditions of stirring at low speed
In above-mentioned glycerinated bare substrate (after addition, drug extract account for gross weight 3%), dispersed with stirring is uniform, is coated with while hot
On non-woven fabrics, it is cooled to room temperature cutting blocking.
Embodiment 2 prepares the paste for the treatment of precancerous lesions of chronic atrophic gastritis
Prescription is：Radix Astragali 28g, Sculellaria barbata 20g, coix seed 28g, stir-baked RHIZOMA SPARGANII with vinegar 8g, root of Dahurain angelica 8g, kaempferia galamga 8g, edible tulip 5g are red
Red-spotted stonecrop 15g, Chinese cassia tree 2g, borneol 4g.
Step is as follows：
(1) Radix Astragali, Sculellaria barbata and rhodiola root are taken, plus 8 times of 50% ethanol solutions of amount, heating and refluxing extraction 2 times, every time
1.5 hours, merge extract solution, filtering, 50~60 DEG C of filtrate is recovered under reduced pressure ethanol, is condensed into thick paste；
Coix seed, the root of Dahurain angelica and edible tulip, plus 8 times of 80% ethanol solutions of amount, heating and refluxing extraction 2 times are taken, 1.5 is small every time
When, merging extract solution, filtering, 50~60 DEG C of filtrate is recovered under reduced pressure ethanol, is condensed into thick paste；
Stir-baked RHIZOMA SPARGANII with vinegar and kaempferia galamga are taken, coarse granule, plus 10 times of water of amount are ground into, soaked 0.5 hour, extracted, collect volatile oil,
Extract solution is filtered, and is concentrated into relative density 1.05, is cooled to room temperature, plus ethanol or ethanol solution make alcohol content to 70%, and 4 DEG C cold
24h is hidden, filtering, 50~60 DEG C of filtrate is recovered under reduced pressure ethanol, is condensed into thick paste, adds the volatile oil of foregoing collection, mixes, and obtains thick
Cream, it is standby；
Chinese cassia tree is taken, fine powder (120 mesh) is ground into, Chinese cassia tree powder is obtained；
Borneol, plus a small amount of ethanol grinding dissolving are taken, Chinese cassia tree powder is added, mixed, add three kinds of thick pastes obtained above (to contain
Volatile oil), mix, drug extract is obtained, it is standby；
(2) drug extract obtained above is added into matrix, is made gel emplastrum (cataplasm)：Remove ionized water 70
Part, 0.001 part and 0.03 part of Tween-80 of disodium ethylene diamine tetraacetate is added, mix, stirring at low speed (60 revs/min), add
2 parts of Carbomer-940 resin, moderate-speed mixer (200 revs/min), point 5 batches of 15 parts of addition Carbomer -941 resins, stirring at low speed 2
Hour, to uniform, pours into kneader, and regulation temperature is 50 DEG C, is stirred 2 hours, is vacuumized, and is stirred, and is stood, and obtains blank base
Matter；
Stirring at low speed bare substrate, regulation pH value to 5 (is slowly added to the NaOH solution regulation that mass fraction is 10%), together
When be slowly added to glycerine the 15% of bare substrate volume (addition for), mix, obtain glycerinated bare substrate；
Drug extract is suspended in 3 times of 95% ethanol solutions of volume, is slowly added under the conditions of stirring at low speed
In above-mentioned glycerinated bare substrate (after addition, drug extract account for gross weight 1%), dispersed with stirring is uniform, is coated with while hot
On non-woven fabrics, it is cooled to room temperature cutting blocking.
Embodiment 3 prepares the paste for the treatment of precancerous lesions of chronic atrophic gastritis
Prescription is：Radix Astragali 32g, Sculellaria barbata 16g, coix seed 32g, stir-baked RHIZOMA SPARGANII with vinegar 5g, root of Dahurain angelica 10g, kaempferia galamga 5g, edible tulip 8g,
Rhodiola root 10g, Chinese cassia tree 4g, borneol 2g.
Step is as follows：
(1) Radix Astragali, Sculellaria barbata and rhodiola root are taken, plus 8 times of 50% ethanol solutions of amount, heating and refluxing extraction 2 times, every time
1.5 hours, merge extract solution, filtering, 50~60 DEG C of filtrate is recovered under reduced pressure ethanol, is condensed into thick paste；
Coix seed, the root of Dahurain angelica and edible tulip, plus 8 times of 80% ethanol solutions of amount, heating and refluxing extraction 2 times are taken, 1.5 is small every time
When, merging extract solution, filtering, 50~60 DEG C of filtrate is recovered under reduced pressure ethanol, is condensed into thick paste；
Stir-baked RHIZOMA SPARGANII with vinegar and kaempferia galamga are taken, coarse granule, plus 10 times of water of amount are ground into, soaked 0.5 hour, extracted, collect volatile oil,
Extract solution is filtered, and is concentrated into relative density 1.05, is cooled to room temperature, plus ethanol or ethanol solution make alcohol content to 70%, and 4 DEG C cold
24h is hidden, filtering, 50~60 DEG C of filtrate is recovered under reduced pressure ethanol, is condensed into thick paste, adds the volatile oil of foregoing collection, mixes, and obtains thick
Cream, it is standby；
Chinese cassia tree is taken, fine powder (120 mesh) is ground into, Chinese cassia tree powder is obtained；
Borneol, plus a small amount of ethanol grinding dissolving are taken, Chinese cassia tree powder is added, mixed, add three kinds of thick pastes obtained above (to contain
Volatile oil), mix, drug extract is obtained, it is standby；
(2) drug extract obtained above is added into matrix, is made gel emplastrum (cataplasm)：Remove ionized water 70
Part, 0.003 part and 0.01 part of Tween-80 of disodium ethylene diamine tetraacetate is added, mix, stirring at low speed (90 revs/min), add
2 parts of Carbomer-940 resin, moderate-speed mixer (400 revs/min), point 3 batches of 15 parts of addition Carbomer -941 resins, stirring at low speed 2
Hour, to uniform, pours into kneader, and regulation temperature is 50 DEG C, is stirred 2 hours, is vacuumized, and is stirred, and is stood, and obtains blank base
Matter；
Stirring at low speed bare substrate, regulation pH value to 7 (is slowly added to the NaOH solution regulation that mass fraction is 10%), together
When be slowly added to glycerine the 23% of bare substrate volume (addition for), mix, obtain glycerinated bare substrate；
Drug extract is suspended in 3 times of 95% ethanol solutions of volume, is slowly added under the conditions of stirring at low speed
In above-mentioned glycerinated bare substrate (after addition, drug extract account for gross weight 5%), dispersed with stirring is uniform, is coated with while hot
On non-woven fabrics, it is cooled to room temperature cutting blocking.
Clinical research data
" the easypro ruffian particle of stilbene lotus is reversed seminar's early stage national natural science fund subsidy project where the present inventor
The study mechanism of CAG precancerous lesions " (NO：30973826) and national science and technology key special subjects " pharmacology of compound Chinese medicines study and medicine
Effect is learned and evaluates key technology " (NO：2009ZX09502-015) (concluding) research show that prescription of the invention is can be from polycyclic
Effective prescription of section, Mutiple Targets blocking and reverse CAG precancerous lesions." reason controlled outward, i.e., the interior reason controlled, the medicine controlled outward is that is, interior to control
Medicine ".The present invention carries out technique, quality, stability etc. to " stilbene lotus relax ruffian side " and studies, and is developed into " stilbene lotus cream ", whole with the traditional Chinese medical science
The physiological function of body idea, theory of channels and collaterals and acupuncture points on the human body is theoretical foundation, and innovation is played in special efficacy using the method for point-application
CAG precancerous lesions are treated in the external application ruling by law of medication thing.It is special that clinical study results report is as follows.
1 clinical data
1.1 diagnostic criteria Western medicine diagnostic criteria references《Practical clinical practice》And 2006《Chinese chronic gastritis common recognition meaning
See》.
1. 1.2 inclusive criterias meet CAG diagnostic criteria；2. all cases are examined before including experiment through electronic gastroscope and pathology
Look into and make a definite diagnosis；3. pathologic finding is with intestinal metaplasia or dysplasia；4. age 18~65 years old；5. this problem of patient's voluntary participation
And sign Informed Consent Form.
1. 1.3 exclusion standards merge gastric and duodenal ulcer person；2. stomach lining has severe dysplasia or pathological diagnosis
Suspect canceration person；3. merge intentionally, brain, liver, kidney, the severe primary disease patient such as lung and hematological system；4. mental patient；⑤
Gestation or women breast-feeding their children；6. allergic constitution or to two or more medicines and to principal component allergy sufferers in research medicine.
1.4 physical data cases digest from Hospital Attached to Shandong Chinese Medical Univ.'s in January, 2014 in December, 2016
Internal clinic CAG precancerous lesions patient 120, random digits table by patient be divided into stilbene lotus cream group, stilbene lotus relax ruffian particle group and
The multiple spring group of stomach, every group each 40.Man 23 in stilbene lotus cream group, female 17,25~64 years old age, average age (51.60 ±
7.24) year, the course of disease 6 months~17 years, average (4.35 ± 4.58) year.Man 22, female 18, age in the easypro ruffian particle group of stilbene lotus
26~65 years old, average age (49.23 ± 6.77) year, the course of disease 5 months~15 years, average (4.18 ± 5.54) year.The multiple spring group of stomach
Middle male 21, female 19,28~66 years old age, average age (50.91 ± 7.98) year, the course of disease 4 months~16 years, averagely
(4.56 ± 5.02) year.Each group patient is not statistically significant (P ＞ 0.05) in the aspect difference such as sex, age, course of disease, has
Comparativity.
2 methods
2.1 treatment methods
Stilbene lotus cream group：Stilbene lotus cream (prepared by paste of the invention, embodiment 1) point-application is given (often to paste dose equivalent to life
Medicine 20g), stick the middle part of gastric cavity, Zusanli, spleen acupoint, stomach acupuncture points on the human body.Change 1 plaster within every 2 days, often stick 6 days, disable 1 day.
The easypro ruffian particle group of stilbene lotus：Give stilbene lotus easypro ruffian particle (Radix Astragali 24g, Sculellaria barbata 12g, fruit of glossy privet 9g, curcuma zedoary 6g, Job's tears
Benevolence 24g is constituted), often bag particle is equivalent to crude drug 10g (production of People's Hospital of Weifang City pharmaceutical factory).Usage：Each 10g, daily 3
Secondary, warm water is taken after mixing it with water.
The multiple spring group of stomach：Give WEIFUCHUN PIAN oral, specification：0.359g × 60 piece/bottle, Chinese medicines quasi-word Z33020146, by Hangzhou
Hu Qingyu Pharmaceutical Workshop pharmaceutcal corporation, Ltd produces, and 4 tablets once, and 3 times a day.
Each group 3 months is 1 course for the treatment of, 2 courses for the treatment of of medication.
2.2 observation index and method treatment fore-and-aft observing symptom, sign situation of change, and carry out gastrocopy and pathology refers to
The observation of target situation of change carries out efficacy evaluation.Pathological index indexes standard reference《Chinese National Consensus on Chronic Gastritis》Standard：
1. inflammation：Slightly：Inflammatory cell infiltration is located at more than foveolae gastricae bottom.Moderate：Inflammatory cell infiltration is as deep as body of gland tunica propria.Weight
Degree：Inflammatory cell infiltration is as deep as muscularis mucosae.2. atrophy：Slightly：The atrophy of intrinsic body of gland is reduced within 1/3.Moderate：Intrinsic body of gland
Atrophy reduces 1/3~2/3.Severe：The atrophy of intrinsic body of gland reduces more than 2/3.3. intestinal metaplasia：Slightly：Intestines superficial epithelium
Or/and body of gland accounts for less than the 1/3 of mucous membrane total length.Moderate：Intestines superficial epithelium or/and body of gland account for the 1/3~2/3 of mucous membrane total length.
Severe：Intestines superficial epithelium or/and body of gland account for more than the 2/3 of mucous membrane total length.4. dysplasia：Slightly：Nucleus is slightly larger, deep
Dye, rounded, oval or column, arrange comparatively dense, positioned at cell substrate.Such as it is gastric pattern, epithelial cell is in the form of a column, mucus point
Secrete reduction；Such as it is visible peristalsis visible intestinal peristalsis, goblet cell is reduced, rare paneth's cell.Hyperplasia that glandular tube is slight, tube chamber is slightly irregular, arranges slightly disorderly
It is random and of uneven density.Moderate：Cell atypia is more apparent.Nucleus increases, and oval or shaft-like is not of uniform size, and dense dye is intensive, row
Relatively disorderly, uneven, in false multilayer structure, nuclear fission is more for row.Epithelial cell is in the form of a column, and mucilage secretion is significantly reduced, cup-shaped
Cell is rare, loses paneth's cell.Glandular tube arranges comparatively dense, has branch tortuous, and luminal structure is irregular, shape size.
Severe：Cell atypia clearly, is difficult to differentiate between with differentiated mucous membrane endothelial carcinoma sometimes.Epithelial cell is in high column (intestines
Type), lose goblet cell and paneth's cell；Or in cube, indefinite form (gastric pattern), mucilage secretion defunctionalization.Nucleus is bright
Aobvious increase, size, shape differ, and arrangement disorder is uneven, and core/born of the same parents' ratio increase, dense dye or loose netted, kernel is obvious,
Mitotic figure is common.Glandular tube structure is substantially disorderly, shape size and arrangement irregular, it is common sprout, branch, nipple, altogether wall and
Back-to-back phenomenon.
2.3 comprehensive therapeutic effect evaluation criteria references《New Chinese medicine guideline of clinical investigations》.1. clinical recovery：Clinical condition
Shape, sign disappear, and gastroscope check mucous membrane chronic inflammation is clearly better up to slightly, and histopathologic examination confirms body of gland atrophy, intestines
Epithelial metaplasia and dysplasia recover normal or disappear.2. it is effective：Clinical symptoms, sign disappear, gastroscope check mucous membrane chronic inflammation
Disease is taken a turn for the better, and histopathologic examination confirms that body of gland atrophy, intestinal metaplasia or dysplasia recover normal or mitigate 2 level degree.
3. it is effective：Clinical symptoms, sign substantially mitigate, gastroscope check gastric mucosal lesions range shorter more than 1/2, histopathologic examination
Confirm that chronic inflammation mitigates more than 1 level degree, body of gland atrophy, intestinal metaplasia and dysplasia mitigate.4. it is invalid：Not up to have
Criterion standard or deterioration person.
2.4 gastroscopy effect criterion references《New Chinese medicine guideline of clinical investigations》Draft：1. cure：Gastroscope is checked
Mucous membrane chronic inflammation is clearly better up to slightly.2. it is effective：Gastroscope check mucous membrane chronic inflammation takes a turn for the better.3. it is effective：Gastroscope checks stomach
Non-cancer lesion range shorter more than 1/2.4. it is invalid：Not up to effective standard or deterioration person.
2.5 Efficacy of Traditional Chinese Medicine indexs were with reference to 2002《New Chinese medicine guideline of clinical investigations》In new Chinese medicine treatment it is slow
Property atrophic gastritis guideline of clinical investigations judge.Primary symptom：Gastral cavity pain, gastral cavilty feeling of fullness；Secondary disease：It is indigestion and loss of appetite weak, noisy
Belch.Primary symptom according to the state of an illness without, it is light, in, remember 0 point, 2 points, 4 points, 6 points respectively again, secondary disease according to the state of an illness without, it is light, in, distinguish again
Integration change before and after 0 point, 1 point, 2 points, 3 points of note, comparison therapy.
2.6 statistical methods use SPSS19.0 statistical softwares, measurement data withExpression, enumeration data use side
Difference is analysed, and ranked data use rank test, and P ＜ 0.05 are that difference is statistically significant.
3 results
3.1 each group Patient Global's comparitive studies
Stilbene lotus cream group compares with the multiple spring group of stomach, and recovery from illness, effective, effective situation have notable significant difference (P ＜ 0.01),
There is significant difference (P ＜ 0.05) in total effective rate.The recovery from illness of stilbene lotus cream group, effective, effective patient are more than the easypro ruffian particle group of stilbene lotus,
But two groups do not exist significant difference (P ＞ 0.05).It is shown in Table 1.
The each group comprehensive therapeutic effect of table 1 compares
Note：Compare with stilbene lotus cream group, * P ＜ 0.05, * * P ＜ 0.01.
3.2 each group patient's gastroscopy effects compare
Stilbene lotus cream group is cured, effective, effective patient is more than easypro ruffian particle group (P ＜ 0.05) of stilbene lotus and stomach multiple spring group (P ＜
0.01) stilbenes lotus cream group gastroscopy effect total effective rate is better than other two groups, there is significant difference (P ＜ 0.05).It is shown in Table 2.
The each group gastroscopy effect of table 2 compares
Note：Compare with stilbene lotus cream group, * P ＜ 0.05, * * P ＜ 0.01.
3.3 each group patient's pathological changes are compared
Before treatment, each group no difference of science of statistics (P ＞ 0.05) in terms of pathology.
Stilbene lotus cream group and the easypro ruffian particle group of stilbene lotus, after treatment before relatively treatment in terms of mucosal inflammation, atrophy, intestinal metaplasia
Have clear improvement (P ＜ 0.05), and dysplasia is not improved (P ＞ 0.05)；Inflammation, atrophy are relatively controlled after the multiple spring group treatment of stomach
Improve substantially (P ＜ 0.05) before treating, intestinal metaplasia, dysplasia are not improved (P ＞ 0.05).
Aspect of inflammation, the stilbene lotus cream group state of an illness improves better than easypro ruffian particle group (P ＜ 0.05) of stilbene lotus and the multiple spring group of stomach after treatment
(P ＜ 0.01)；Atrophy aspect, the stilbene lotus cream group state of an illness improved better than easypro ruffian particle group (P ＜ 0.05) of stilbene lotus and stomach multiple spring after treatment
Group (P ＜ 0.01)；Intestinal metaplasia aspect, the stilbene lotus cream group state of an illness improves better than stomach multiple spring group (P ＜ 0.05), with stilbene lotus after treatment
Ruffian particle group of relaxing compares no difference of science of statistics (P ＞ 0.05)；Dysplasia aspect, effect no difference of science of statistics (P after each group treatment
＞ 0.05), it is shown in Table 3.
The each group pathological change of table 3 is compared (example)
The improvement of 3.4 each group patient symptoms is compared
3.4.1 gastral cavity pain integral contrast
Gastral cavity pain integration is decreased obviously after the treatment of stilbene lotus cream group, has notable significant difference (P ＜ with comparing before treatment
0.01)；After treatment, stilbene lotus cream group gastral cavity pain improves situation and is better than other two groups, there is significant difference (P ＜ 0.05).See
Table 4.
The each group gastral cavity pain integral contrast of table 4
Note：Compare with after the treatment of stilbene lotus cream group, * P ＜ 0.05, * * P ＜ 0.01；Compare with before same group treatment, △ P ＜
0.05, △ △ P ＜ 0.01.
3.4.2 gastral cavilty feeling of fullness integral contrast
Gastral cavilty feeling of fullness is obviously improved after the treatment of stilbene lotus cream group, has notable significant difference (P ＜ 0.01) with comparing before treatment.
Stilbene lotus cream group improves gastral cavilty feeling of fullness symptom and is better than other two groups, compares with the easypro ruffian particle group of stilbene lotus and there is significant difference (P ＜
0.05), compare with the multiple spring group of stomach and there is notable significant difference (P ＜ 0.01).It is shown in Table 5.
The each group gastral cavilty feeling of fullness integral contrast of table 5
Note：Compare with after the treatment of stilbene lotus cream group, * P ＜ 0.05, * * P ＜ 0.01；Compare with before same group treatment, △ P ＜
0.05, △ △ P ＜ 0.01.
3.4.3 indigestion and loss of appetite weak integral contrast
Each group treatment after it is indigestion and loss of appetite it is weak be obviously improved, have notable significant difference (P ＜ 0.01) with comparing before treatment；Receiving
Slow-witted weak improvement situation aspect, does not exist significant difference (P ＞ 0.05) after each group treatment.It is shown in Table 6.
The indigestion and loss of appetite weak integral contrast of each group of table 6
Note：Compare with after the treatment of stilbene lotus cream group, * P ＜ 0.05, * * P ＜ 0.01；Compare with before same group treatment, △ P ＜
0.05, △ △ P ＜ 0.01.
3.4.4 gastric upset and eructation integral contrast
Gastric upset and eructation is obviously improved after each group treatment, there is notable significant difference (P ＜ 0.01) with comparing before treatment.Stilbene
Lotus cream group improves gastric upset and eructation symptom better than the easypro ruffian particle group of stilbene lotus and the multiple spring group of stomach, there is significant difference (P ＜ 0.05).See
Table 7.
The each group gastric upset and eructation integral contrast of table 7
Note：Compare with after control group treatment, * P ＜ 0.05, * * P ＜ 0.01；Compare with before test group treatment, △ P ＜
0.05, △ △ P ＜ 0.01.
3.5 safety evaluatios
There is not obvious clinical adverse over the course for the treatment of, in each group, and patient compliance is preferable.
4 discuss
Stilbene lotus herbal paste is selected：Radix Astragali 30g, Sculellaria barbata 18g, coix seed 30g, stir-baked RHIZOMA SPARGANII with vinegar 6g, root of Dahurain angelica 9g, kaempferia galamga 6g, edible tulip
6g, rhodiola root 12g, Chinese cassia tree 6g, borneol 3g.Paste point-application is made using modern crafts.This formula is relaxed in original stilbene lotus
On the basis of ruffian particle prescription, the consumption of original medicine Radix Astragali, Sculellaria barbata and coix seed is increased, its tonifying Qi myogenic, cool blood dissipate
The stasis of blood, the power of clearing damp and promoting diuresis dissipating bind are stronger；Stir-baked RHIZOMA SPARGANII with vinegar instead of stir-baked RHIIZOMA CURCUMAE with vinegar, and stir-baked RHIZOMA SPARGANII with vinegar and stir-baked RHIIZOMA CURCUMAE with vinegar have regulating qi to disperse stagnation, and promoting the circulation of qi stops
Bitterly, disperse accumulations effect, but stir-baked RHIZOMA SPARGANII with vinegar dissipating blood stasis with potent drugs effect is stronger, and stir-baked RHIIZOMA CURCUMAE with vinegar is more partial to promoting the circulation of qi.The easypro ruffian particle side of original stilbene lotus is gone
Fall the fruit of glossy privet, be changed to Chinese cassia tree, the fruit of glossy privet has tonified the liver and kidney, acted on gentle, and Chinese cassia tree warms up spleen kidney, complement sun, promoting blood circulation, kidney tonifying is led to
Arteries and veins strength is stronger, and increases the root of Dahurain angelica, kaempferia galamga, edible tulip, rhodiola root, Chinese cassia tree, the medicine such as borneol.
The traditional Chinese medical science thinks, precancerous lesions of chronic atrophic gastritis is so that taste are deficient, deficiency of both qi and yin for this, it is qi and blood stasis, damp and hot
It is mark to pent up., in stomach, pathology is centered on spleen kidney deficiency damage for diseased region.Tonifying speen and tonifying kidney, regulating qi to disperse stagnation, heat-clearing are established accordingly
Wet, powder detoxifcation therapy.Select the gas of the kind tonifying spleen and stomach of the Radix Astragali, myogenic blood-nourishing in side.Sculellaria barbata is apt to clearing heat and detoxicating, cool blood dissipates the stasis of blood, and
Can anticancer analgetic.Coix seed invigorating spleen for diuresis excreting dampness, detoxicating and resolving a mass.Root of Dahurain angelica wind-damp dispelling, apocenosis of invigorating blood circulation, myogenic pain relieving.Stir-baked RHIZOMA SPARGANII with vinegar row
The gasification stasis of blood, promoting qi circulation and relieving pain, disperse accumulations.Kaempferia galamga promoting the circulation of qi middle benefit gas, analgesic.Edible tulip is clearing heat and detoxicating, reducing phlegm and resolving masses.Rhodiola root tonifying Qi is supported
The heart, controlling of bleeding with astringents, eliminating stasis to subdue swelling, Chinese cassia tree complement sun, warming spleen and stomach, removing internal cold, promoting blood circulation.Borneol is clearing heat and detoxicating, erosion prevention and muscle growing.It is all
Medicine shares the work(for playing strengthening spleen, tonifying kidney, benefiting qi for promoting granulation, regulating qi to disperse stagnation, clearing away heat and eliminating dampeness, detoxicating and resolving a mass altogether.
Clinical study results show that " stilbene lotus cream " treats precancerous lesions of chronic atrophic gastritis using the method for point-application
The comprehensive therapeutic effect of patient is favorably improved, improves patient's gastric mucosal lesion and pathology, gastral cavity pain, gastral cavilty ruffian can be effectively improved
The diseases such as full, indigestion and loss of appetite weak, gastric upset and eructation, are favorably improved patients ' life quality." stilbene lotus cream " is improving patient's gastric mucosal lesion
And pathology, alleviate the aspects such as gastral cavity pain, gastral cavilty feeling of fullness, gastric upset and eructation better than the easypro ruffian particle of stilbene lotus, there is significant difference (P
＜ 0.05)." stilbene lotus cream " is in terms of comprehensive therapeutic effect, and improves patient's gastric mucosal lesion and pathology, alleviates gastral cavity pain, gastral cavilty
There is significant difference (P ＜ 0.05) better than the multiple spring group of stomach in the aspects such as feeling of fullness, gastric upset and eructation.
" reason controlled outward, i.e., the interior reason controlled, the medicine controlled outward, i.e., the interior medicine controlled ".The present invention is to original " the easypro ruffian particle of stilbene lotus "
Carry out medicine clinical effectiveness it is preferred, and to technique, quality, stability etc. study, " stilbene lotus cream " is developed into, with traditional Chinese medical science entirety
The physiological function of idea, theory of channels and collaterals and acupuncture points on the human body is theoretical foundation, using the side for sticking the middle part of gastric cavity, Zusanli, spleen acupoint, stomach acupuncture points on the human body
Method, makes medicine excite acupuncture point that therapeutic action is played through the approach of gas by direct subcutaneous absorption and indirect stimulation.Not only act on
Directly, and inexpensive medicine is simple, noninvasive painless.
The present invention using point-application external therapy, Yu of selecting coordinated synergy raises adjunct acupuncture points, " drawing the moon from sun, sun is drawn from the moon "
Treatment gastric precancerous lesion, not only acts on direct, clear curative effect, and simple and easy to do, inexpensive medicine is simple, noninvasive painless, fully demonstrates
The advantage of external treatment of traditional Chinese medicine.Additionally, selected efficient Chinese medicine and careful prescription compatibility, carry out series of studies, formation process rationally,
The good modern Chinese herbal medicine externally used paste of quality controllable, preparation stabilization, determined curative effect, security, further increases pharmacoeconomics
Benefit is it in clinical application, there is provided safely and effectively ensured.
5 conclusions
" stilbene lotus cream " clinical application effect of the invention is substantially better than " the easypro ruffian particle of stilbene lotus " and clinical conventional Chinese patent drug stomach
Multiple spring, security is good, and its treatment is simple and easy to do in addition, inexpensive medicine is simple, is that it provides safeguard in clinical expansion.
Claims (6)
1. a kind of paste for treating precancerous lesions of chronic atrophic gastritis, it is characterised in that：It is made up of following bulk drug：It is yellow
28~32g of stilbene, 16~20g of Sculellaria barbata, 28~32g of coix seed, 5~8g of stir-baked RHIZOMA SPARGANII with vinegar, 8~10g of the root of Dahurain angelica, 5~8g of kaempferia galamga, edible tulip
5~8g, 10~15g of rhodiola root, 2~4g of Chinese cassia tree, 2~4g of borneol.
2. it is according to claim 1 treatment precancerous lesions of chronic atrophic gastritis paste, it is characterised in that：It is by following
What bulk drug was made：Radix Astragali 30g, Sculellaria barbata 18g, coix seed 30g, stir-baked RHIZOMA SPARGANII with vinegar 6g, root of Dahurain angelica 9g, kaempferia galamga 6g, edible tulip 6g, red scape
Its 12g, Chinese cassia tree 6g, borneol 3g.
3. it is according to claim 1 and 2 treatment precancerous lesions of chronic atrophic gastritis paste, it is characterised in that：It is logical
Cross what following methods were prepared：
(1) Radix Astragali, Sculellaria barbata and rhodiola root, plus 8 times of 50% ethanol solutions of amount, heating and refluxing extraction 2 times are taken, 1.5 is small every time
When, merging extract solution, filtering, 50~60 DEG C of filtrate is recovered under reduced pressure ethanol, is condensed into thick paste；
Take coix seed, the root of Dahurain angelica and edible tulip, plus 8 times of 80% ethanol solutions of amount, heating and refluxing extraction 2 times, 1.5 hours every time,
Merge extract solution, filtering, 50~60 DEG C of filtrate is recovered under reduced pressure ethanol, is condensed into thick paste；
Stir-baked RHIZOMA SPARGANII with vinegar and kaempferia galamga are taken, coarse granule, plus 10 times of water of amount are ground into, soaked 0.5 hour, extracted, collect volatile oil, extracted
Liquid is filtered, concentration, is cooled to room temperature, plus ethanol or ethanol solution make alcohol content to 70%, 4 DEG C of refrigeration 24h, filtering, filtrate 50
~60 DEG C are recovered under reduced pressure ethanol, are condensed into thick paste, add the volatile oil of foregoing collection, mix, and obtain thick paste, standby；
Chinese cassia tree is taken, fine powder is ground into, Chinese cassia tree powder is obtained；
Borneol, plus ethanol grinding dissolving are taken, Chinese cassia tree powder is added, mixed, add three kinds of thick pastes obtained above, mixed, obtain medicine
Thing extract, it is standby；
(2) drug extract obtained above is added into matrix, is made gel emplastrum.
4. it is according to claim 3 treatment precancerous lesions of chronic atrophic gastritis paste, it is characterised in that：The step
(2) specific method is：70 parts of water intaking, 0.001~0.003 part and Tween-80 0.01 of addition disodium ethylene diamine tetraacetate~
0.03 part, mix, stirring at low speed, add 2 parts of Carbomer-940 resin, moderate-speed mixer, point 3~5 batches of addition Carbomers -941 to set
15 parts of fat, stirring at low speed pours into kneader in 2 hours to uniform, and regulation temperature is 50 DEG C, is stirred 2 hours, is vacuumized, and stirring is equal
It is even, stand, obtain bare substrate；
Stirring at low speed bare substrate, regulation pH value is to 5~7, while being slowly added to glycerine, addition is bare substrate volume
15%~23%, mix, obtain glycerinated bare substrate；
Drug extract is suspended in 3 times of 95% ethanol solutions of volume, is slowly added under the conditions of stirring at low speed above-mentioned
In glycerinated bare substrate, after addition, drug extract accounts for the 1%~5% of gross weight, and dispersed with stirring is uniform, is coated with while hot
On non-woven fabrics, it is cooled to room temperature, cutting is blocking, obtains final product.
5. according to any one of Claims 1 to 4 treatment precancerous lesions of chronic atrophic gastritis paste preparation side
Method, it is characterised in that：Comprise the following steps：
(1) Radix Astragali, Sculellaria barbata and rhodiola root, plus 8 times of 50% ethanol solutions of amount, heating and refluxing extraction 2 times are taken, 1.5 is small every time
When, merging extract solution, filtering, 50~60 DEG C of filtrate is recovered under reduced pressure ethanol, is condensed into thick paste；
Take coix seed, the root of Dahurain angelica and edible tulip, plus 8 times of 80% ethanol solutions of amount, heating and refluxing extraction 2 times, 1.5 hours every time,
Merge extract solution, filtering, 50~60 DEG C of filtrate is recovered under reduced pressure ethanol, is condensed into thick paste；
Stir-baked RHIZOMA SPARGANII with vinegar and kaempferia galamga are taken, coarse granule, plus 10 times of water of amount are ground into, soaked 0.5 hour, extracted, collect volatile oil, extracted
Liquid is filtered, concentration, is cooled to room temperature, plus ethanol or ethanol solution make alcohol content to 70%, 4 DEG C of refrigeration 24h, filtering, filtrate 50
~60 DEG C are recovered under reduced pressure ethanol, are condensed into thick paste, add the volatile oil of foregoing collection, mix, and obtain thick paste, standby；
Chinese cassia tree is taken, fine powder is ground into, Chinese cassia tree powder is obtained；
Borneol, plus ethanol grinding dissolving are taken, Chinese cassia tree powder is added, mixed, add three kinds of thick pastes obtained above, mixed, obtain medicine
Thing extract, it is standby；
(2) drug extract obtained above is added into matrix, is made gel emplastrum.
6. preparation method according to claim 5, it is characterised in that：The specific method of the step (2) is：Water intaking 70
Part, 0.001~0.003 part and 0.01~0.03 part of Tween-80 of disodium ethylene diamine tetraacetate is added, mix, stirring at low speed, plus
Enter 2 parts of Carbomer-940 resin, moderate-speed mixer, points 3~5 batches add 15 parts of the resins of Carbomer -941, and stirring at low speed 2 hours is to equal
It is even, kneader is poured into, regulation temperature is 50 DEG C, is stirred 2 hours, is vacuumized, and is stirred, and is stood, and obtains bare substrate；
Stirring at low speed bare substrate, regulation pH value is to 5~7, while being slowly added to glycerine, addition is bare substrate volume
15%~23%, mix, obtain glycerinated bare substrate；
Drug extract is suspended in 3 times of 95% ethanol solutions of volume, is slowly added under the conditions of stirring at low speed above-mentioned
In glycerinated bare substrate, after addition, drug extract accounts for the 1%~5% of gross weight, and dispersed with stirring is uniform, is coated with while hot
On non-woven fabrics, it is cooled to room temperature, cutting is blocking, obtains final product.
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|---|---|---|---|---|
| CN111643637A (en) * | 2020-07-06 | 2020-09-11 | 河北省中医院 | Traditional Chinese medicine composition for preventing and treating chronic atrophic gastritis and gastric precancerous lesions and preparation method and application thereof |
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| CN101596299A (en) * | 2009-07-16 | 2009-12-09 | 王有广 | A kind of Chinese medicine pill for the treatment of precancerous lesions of chronic atrophic gastritis |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101596299A (en) * | 2009-07-16 | 2009-12-09 | 王有广 | A kind of Chinese medicine pill for the treatment of precancerous lesions of chronic atrophic gastritis |
Non-Patent Citations (2)
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| 吕林懋等: "芪莲舒痞汤治疗慢性萎缩性胃炎癌前病变的临床研究", 《中国中西医结合消化杂志》 * |
| 王笃桂等: "以络病理论芪莲舒痞汤治疗慢性萎缩性胃炎(CAG)癌前病变(PLGC)的疗效研究", 《当代医学》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111643637A (en) * | 2020-07-06 | 2020-09-11 | 河北省中医院 | Traditional Chinese medicine composition for preventing and treating chronic atrophic gastritis and gastric precancerous lesions and preparation method and application thereof |
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