CN105878426A - Function of traditional Chinese medicine radix paeoniae alba on treating depression - Google Patents
Function of traditional Chinese medicine radix paeoniae alba on treating depression Download PDFInfo
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- CN105878426A CN105878426A CN201510028773.5A CN201510028773A CN105878426A CN 105878426 A CN105878426 A CN 105878426A CN 201510028773 A CN201510028773 A CN 201510028773A CN 105878426 A CN105878426 A CN 105878426A
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Abstract
The invention relates to a traditional Chinese medicine, namely radix paeoniae alba, and the radix paeoniae alba is discovered to have a function of treating depression. The radix paeoniae alba, when used independently or added to and combined with other traditional Chinese medicines, can develop the function of the treating the depression. Cases treated by the radix paeoniae alba are as shown in a Table below: clinical results of treating 360 cases of the depression with the radix paeoniae alba (as shown in Description).
Description
(1) technical field
The present invention relates to a kind of Chinese medicine Radix Paeoniae Alba, no matter single medicinal material uses, and is still added in other Chinese medicine
In prescription use, all have treatment depression function.
(2) background technology
The overview of depression:
Depression is a kind of with psychiatric condition that depressive mood is main performance.At present, the pressing down of developed country
Strongly fragrant disease is 15 kinds of one of reasons that mainly disable.Data show, the U.S. there are about 1 100 ten thousand people every year and suffers from Clinical depression
Disease, the homicide rate of clinical depression patient is 10%～15%.National survey data shows, depression from
Rate of killing is higher 20 times than population.Predicting the year two thousand twenty, depression will become the mankind being only second to cancer
Two big disability-causing factors.Psychosomatic medicine, medicopsychology, psychiatry research data recently shows, typically
The prevalence of psychosomatic disease depression has exceeded cardiovascular and cerebrovascular disease and tumor, leaps to the of developed country
One.Therefore, analyze the present Research of depression, inquire into the goal in research of depression in the future, further investigation
The preventing and treating of depression, is of great importance to human society and family.
The pathogenesis of depression is the most complicated, at present, illustrates the most completely, only have some research and
Hypothesis.These hypothesis all have some result of study supports, and the pathogenesis of some depression can be described, but, these are false
Say and by other results of study negated, and the pathogenesis of all depressions can not be described completely.
It is now recognized that depression is possibly due to caused by following reason:
1, depression is the different substantiality disease rather than a kind of disease that one group of cause of disease is different with pathogenesis.Due to respectively
There is its reason fallen ill and pathogenesis, therefore cannot explain by the same cause of disease and pathogenesis.
2, depression is a kind of disease, but has multiple pathogenic factor and pathogenesis.Many pathogenic factors and morbidity machine
System runs up to a certain degree, when exceeding human body self compensatory capacity or compensatory threshold value, just causes morbidity.
Several main hypothesis of depression mechanism is:
1, norepinephrine (NE) function reduction theory in depressive patients brain, it is believed that depression is due in brain
(NE) not enough caused, in central nervous system (NE)
Content declines, then depression occurs, otherwise, then there is mania.
2, beta receptor, alpha-2 receptor sensitivity theory in depressive patients brain: speculate that depression is due to NE merit in brain
Can reduce for a long time, and make beta receptor produce compensatory sensitivity and increase.Postsynaptic beta receptor is super quick can feed back again presynaptic α 2
Receptor is super quick, causes NE to generate release and reduces, depression occurs.
3, depression NE function strengthens theory: having research display depression is that NE raises rather than not enough.
4,5---hydroxytryptamine and receptors hypothesis: think that depression is 5-hydroxy tryptamine in central nervous system (5--HT)
Release reduces, and it is caused that synaptic space content declines shortage.
At present, the Western medicine for the treatment of depression has three class medicines,
1, oxidase inhibitor；
2, tricyclic antidepressant preparation；
3, serotonin reuptake inhibitor.
Owing to the cause of disease and the pathogenesis of depression are unclear, so, current antidepressant Western medicine also can only be to play
The effect cured the symptoms, not the disease, Western medicine has bigger side effect simultaneously.
As a example by the most conventional antidepressants paroxetine, untoward reaction has:
Blood and lymphsystem: abnormal bleeding, be mainly seen in skin and mucosa.
Immune system: anaphylaxis.
Hormonal system；Antidiuretic hormone secretion abnormal syndrome.
Metabolism and nutrition: loss of appetite, hyponatremia.
Psychological problem: drowsiness, insomnia, confusion, manic reaction.
Nervous system: dizziness, trembles, extrapyramidal symptoms, faints from fear.Serotonin syndrome (cardiopalmus, confusion,
Hyperhidrosis, hallucination, hyperreflexia, myoclonus, etc.)
Eye: blurred vision, acute glaucoma.
Cardiovascular system: sinus tachycardia, blood pressure is raised and lowered.
Gastrointestinal tract: feel sick, xerostomia, constipation, diarrhoea, liver transaminases raises.
Skin and subcutaneous tissue: erythra, perspire, photosensitivity reaction.
Kidney and urinary system: urine retention.
Reproductive system: sexual dysfunction.
General reaction: faint, periphery edema.
Chinese medicine is for the understanding of depression: depression belongs to " strongly fragrant disease " in Emotional disorder.And " strongly fragrant disease " can divide
For the polytype such as " depression of liver-QI ", " hyperactivity of hesrt-fire and liver-fire ", " phlegm stagnancy vapour lock ".Also have the five internal organs QI and blood deficiency and excess prosperity and decline pathological changes,
People can be made to stimulate sensitivity to increase to external world, and toleration declines, and causes seven emotions excessively to cause a disease.
The application of Chinese medicine Radix Paeoniae Alba treatment depression, just according to Chinese medicine for the understanding of depression, from conditioning viscera function
Starting with, treat depression, the degree of depth excavates the intension of Radix Paeoniae Alba pharmacological effect, has reached the purpose for the treatment of, and pair has seldom occurred
Effect.
Traditional effect of the Radix Paeoniae Alba:
The Radix Paeoniae Alba be ranunculaceae plant Radix Paeoniae remove crust root, be Ranunculaceae Paeonia plant, at present in the Qinling Mountains,
Big not by etc. ground still have wild.Main product in Shandong, Anhui, Zhejiang, Sichuan, Guizhou etc. save, northeast, river
There is cultivation on the ground such as north, Shanxi, the Inner Mongol, Shaanxi.
The Radix Paeoniae Alba is bitter, sour, is slightly cold.Enter Liver Channel.Nourish blood yin fluid astringing, easing the affected liver to relieve pain, suppressing the hyperactive liver sun.It is usually used in:
1. for menoxenia, abdominal pain during menstruation, metrorrhagia, and the disease such as spontaneous perspiration, night sweat.
The Radix Paeoniae Alba can be nourished blood yin fluid astringing, controls gynecological diseases, often and the medicine fit applications such as Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Rhizoma Chuanxiong.This
Product as and Ramulus Cinnamomi
Same use, can coordinate battalion and defend, in order to treat affection of exogenous wind-cold, exterior deficiency spontaneous perspiration and aversion to wind；With Os Draconis,Concha Ostreae、
The medicines such as Fructus Tritici Levis are same
With, can yin fluid astringing YANG hyperactivity suppressing, with controlling the diseases such as spontaneous perspiration caused by floating of YANG due to deficiency of YIN, night sweat.
2. for diseases such as the hypochondriac pain caused by disharmony in liver-QI, stomachache, and contracture of the limbs pain.
Radix Paeoniae Alba function nourishes blood and easing the affected liver, emergency and pain relieving, therefore can be used for the pain in chest and hypochondrium caused by disharmony in liver-QI, carbuncle on the abdominal wall
And contracture of the limbs etc.
Disease.Control hypochondriac pain, be often equal to use with Radix Bupleuri, Fructus Aurantii；Control stomachache and contracture of the limbs, normal and Radix Glycyrrhizae compatibility；As
Control dysentery stomachache,
Use can be equal to Rhizoma Coptidis, the Radix Aucklandiae.
3. for the headache caused by the high Sheng of liver-yang, dizziness.
The raw use of the Radix Paeoniae Alba, can yin fluid astringing and suppressing liver-YANG, therefore can be used for the diseases such as the headache of the high Sheng of liver-yang, dizziness, Chang Yusang
Leaf, Flos Chrysanthemi, hook
Rattan, Fructus Atriplicis Sibiricae equivalent are used.
4. beauty treatment is nourished blood
In theory of Chinese medical science, the Radix Paeoniae Alba has the effect nourished blood, and can treat shallow complexion, facial colour spot, tarnish.
(3) summary of the invention
Present invention aim at proposing a kind of Chinese medicine Radix Paeoniae Alba and have the function for the treatment of depression, (single makes
With or add in prescription use).
Treatment case, see table:
Chinese medicine Radix Paeoniae Alba treatment depression example 360 clinical effectiveness
Claims (1)
1. the present invention relates to a kind of Chinese medicine Radix Paeoniae Alba, find that it has the function for the treatment of depression.No matter single medicinal material, is still added in prescription in other Chinese medicine and uses, all played the function for the treatment of depression.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110538232A (en) * | 2019-09-30 | 2019-12-06 | 青岛琛蓝医药科技发展有限公司 | Anti-depression compound preparation and preparation method thereof |
-
2015
- 2015-01-16 CN CN201510028773.5A patent/CN105878426A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110538232A (en) * | 2019-09-30 | 2019-12-06 | 青岛琛蓝医药科技发展有限公司 | Anti-depression compound preparation and preparation method thereof |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160824 |
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| WD01 | Invention patent application deemed withdrawn after publication |