CN105878642A - Function of traditional Chinese medicine dragon's blood on treating depression - Google Patents

Abstract

The invention relates to a traditional Chinese medicine, namely dragon's blood, and the dragon's blood is discovered to have a function of treating depression. The dragon's blood, when used independently or added to and combined with other traditional Chinese medicines, can develop the function of the treating the depression. Cases treated by the dragon's blood are as shown in a Table below: clinical results of treating 435 cases of the depression with the dragon's blood (as shown in Description).

Description

The function of Chinese medicine Resina draconis treatment depression

(1) technical field

The present invention relates to a kind of Chinese medicine Resina draconis, no matter single medicinal material uses, and is still added in other Chinese medicine In prescription use, all have treatment depression function.

(2) background technology

The overview of depression:

Depression is a kind of with psychiatric condition that depressive mood is main performance.At present, the pressing down of developed country Strongly fragrant disease is 15 kinds of one of reasons that mainly disable.Data show, the U.S. there are about 1 100 ten thousand people every year and suffers from Clinical depression Disease, the homicide rate of clinical depression patient is 10%～15%.National survey data shows, depression from Rate of killing is higher 20 times than population.Predicting the year two thousand twenty, depression will become the mankind being only second to cancer Two big disability-causing factors.Psychosomatic medicine, medicopsychology, psychiatry research data recently shows, typically The prevalence of psychosomatic disease depression has exceeded cardiovascular and cerebrovascular disease and tumor, leaps to the of developed country One.Therefore, analyze the present Research of depression, inquire into the goal in research of depression in the future, further investigation The preventing and treating of depression, is of great importance to human society and family.

The pathogenesis of depression is the most complicated, at present, illustrates the most completely, only have some research and Hypothesis.These hypothesis all have some result of study supports, and the pathogenesis of some depression can be described, but, these are false Say and by other results of study negated, and the pathogenesis of all depressions can not be described completely.

It is now recognized that depression is possibly due to caused by following reason:

1, depression is the different substantiality disease rather than a kind of disease that one group of cause of disease is different with pathogenesis.Due to respectively There is its reason fallen ill and pathogenesis, therefore cannot explain by the same cause of disease and pathogenesis.

2, depression is a kind of disease, but has multiple pathogenic factor and pathogenesis.Many pathogenic factors and morbidity machine System runs up to a certain degree, when exceeding human body self compensatory capacity or compensatory threshold value, just causes morbidity.

Several main hypothesis of depression mechanism is:

1, norepinephrine (NE) function reduction theory in depressive patients brain, it is believed that depression is due in brain (NE) not enough caused, in central nervous system (NE) Content declines, then depression occurs, otherwise, then there is mania.

2, beta receptor, alpha-2 receptor sensitivity theory in depressive patients brain: speculate that depression is due to NE merit in brain Can reduce for a long time, and make beta receptor produce compensatory sensitivity and increase.Postsynaptic beta receptor is super quick can feed back again presynaptic α 2 Receptor is super quick, causes NE to generate release and reduces, depression occurs.

3, depression NE function strengthens theory: having research display depression is that NE raises rather than not enough.

4,5---hydroxytryptamine and receptors hypothesis: think that depression is 5-hydroxy tryptamine in central nervous system (5--HT) Release reduces, and it is caused that synaptic space content declines shortage.

At present, the Western medicine for the treatment of depression has three class medicines,

1, oxidase inhibitor；

2, tricyclic antidepressant preparation；

3, serotonin reuptake inhibitor.

Owing to the cause of disease and the pathogenesis of depression are unclear, so, current antidepressant Western medicine also can only be to play The effect cured the symptoms, not the disease, Western medicine has bigger side effect simultaneously.

As a example by the most conventional antidepressants paroxetine, untoward reaction has:

Blood and lymphsystem: abnormal bleeding, be mainly seen in skin and mucosa.

Immune system: anaphylaxis.

Hormonal system；Antidiuretic hormone secretion abnormal syndrome.

Metabolism and nutrition: loss of appetite, hyponatremia.

Psychological problem: drowsiness, insomnia, confusion, manic reaction.

Nervous system: dizziness, trembles, extrapyramidal symptoms, faints from fear.Serotonin syndrome (cardiopalmus, confusion, Hyperhidrosis, hallucination, hyperreflexia, myoclonus, etc.)

Eye: blurred vision, acute glaucoma.

Cardiovascular system: sinus tachycardia, blood pressure is raised and lowered.

Gastrointestinal tract: feel sick, xerostomia, constipation, diarrhoea, liver transaminases raises.

Skin and subcutaneous tissue: erythra, perspire, photosensitivity reaction.

Kidney and urinary system: urine retention.

Reproductive system: sexual dysfunction.

General reaction: faint, periphery edema.

Chinese medicine is for the understanding of depression: depression belongs to " strongly fragrant disease " in Emotional disorder.And " strongly fragrant disease " The polytype such as " depression of liver-QI ", " hyperactivity of hesrt-fire and liver-fire ", " phlegm stagnancy vapour lock " can be divided into again.Also has the five internal organs QI and blood deficiency and excess prosperity and decline Pathological changes, can make people stimulate sensitivity to increase to external world, and toleration declines, and causes seven emotions excessively to cause a disease.

The application of this Chinese medicine Resina draconis treatment depression, just according to Chinese medicine for the understanding of depression, from conditioning viscera merit Can start with, treat depression, the degree of depth excavates the intension of Sanguis Draxonis pharmacological effect, has reached to treat the purpose of depression, and very Side effect occurs less.

The character of Sanguis Draxonis and tradition effect:

Perennial evergreen liana, up to 10～20 meters, stem is by sheath and all over raw spine.Fruit drupe shape, ovum shape Spherical, about 2～3 centimetres of footpath, russet, have yellow scale, fruit includes the fluid resin of deep also color, often Oozed out by under scale, dry rear such as clot sample.

[habitats distribution] distribution Indonesia, Malaysia, Iran；Also there is plantation in China Guangdong, Taiwan. The ground such as main product Malaysia, Indonesia, Iran.

[character] dry resin is atypic block, differs in size, and surface has rill and Yin Bubao to leave over Woven design, russet or puce.Matter is hard and crisp, and section puce, to pitchy, has hyaloid gloss, Sometimes there is aperture.It is fired, nose of choking of smoldering with fire.It is ground into powder then in bright-coloured peony.Without fragrance, taste Sand sample that is sweet and salty, that chew.With appearance darkish complexion such as ferrum, grinding into powder red such as blood, its cigarette of combustion nose person that chokes is good.

[chemical analysis] is the mixture of a kind of resin ester and dracoresinotannol, containing about 57～82%；Separately contain Unbodied dracoalban about 2.5%, yellow dracoresene about 14%, insoluble resin 0.3%, plant Physical property dregs 18.4%, phlobaphene 0.03%, ash 8.3%.

[pharmacological action] antifungic action.Sanguis Draxonis water logging agent (1: 2) is in vitro to trichophyton, Gypsum Fibrosum The multiple pathomycetes such as sample trichophyton, oidium schoenleinii have inhibitory action in various degree.

[nature and flavor] are sweet salty, flat.

[function cures mainly] dissipating blood stasis analgesic therapy, hemostasia and promoting granulation.Control traumatic injury to lose, ecchymoma due to internal injury；Continuous bleeding due to traumatic injury, Scrofula, ecthyma unhealed for long time.

1. Tang Materia Medica: " main the five internal organs pathogen, leukorrhagia, pain relieving, removing mass blood, gold creation meat.″

②《Haiyao Bencao, Oversea Materia Medica": " leading traumatic fracture damage, all pain, qi-restoratives and vim and vigour stir thorn, and interior blood trouble is gathered, and Preferably wine clothes.″

3. " Japan hanako materia medica ": " control all malignant boil scabies and do not conform to person for a long time, apply.This property of medicine is anxious, also can not make more, But pus is drawn.″

4. Wang Haogu: " reinforcing the heart envelope, deficiency of liver-blood.″

5. " detailed outline ": " dissipate all pains of stagnant blood, married woman's vim and vigour, children's.″

(3) summary of the invention

Present invention aim at proposing a kind of Chinese medicine Sanguis Draxonis and have the function for the treatment of depression, single uses Or addition prescription uses.

Treatment case, see table:

Dragon blood for treating depression 435 example clinical effectiveness

Claims (1)

1. the present invention relates to a kind of Chinese medicine Resina draconis, find that it has the function for the treatment of depression.No matter single medicinal material, is still added in prescription in other Chinese medicine and uses, all played the function for the treatment of depression.