CN105853713A - Traditional Chinese medicine compound, as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine compound, as well as preparation method and application thereof Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine compound for preventing and treating chronic pharyngitis. The preparation method is characterized by comprising the following steps: decocting platycodon grandiflorum, radix ophiopogonis and oroxylum indicum and honey-fried licorice root respectively with five times amount of distilled water, three times amount of distilled water and three times amount of distilled water for two hours each time; mixing the decoctions, and concentrating at reduced pressure. Animal experiments prove that the concentrate has good effects for alleviating pain, removing phlegm, relieving cough and diminishing inflammation. Maximum administration dosage experiment proves that the concentrate has relatively high clinical safety.
Description
Technical field
The present invention relates to the medical usage of a kind of Chinese medicine compound preventing and treating chronic pharyngitis, particularly this compound recipe in treatment
Purposes in chronic pharyngitis.
Background technology
Pharyngitis can be divided into acute pharyngitis and chronic pharyngitis two kinds.Acute pharyngitis is pharyngeal mucosa and sub-mucosal tissues
Acute inflammation.With autumn and winter and the most relatively common.Chronic pharyngitis pathological changes, mainly at mucous layer, shows as pharynx
Portion's mucosa chronic congestion, connective tissue proliferation under mucosa and mucosa, mucous gland is loose, and secretory function is hyperfunction, glutinous
Liquid secretion increases.It is more common in adult, and at the professional population more with throat, such as teacher, reporter, broadcast
Member, performer, salesman, guide, pharyngitis sickness rate is higher.The reason causing pharyngitis has multiple, predominantly
Virus and antibacterial infect, and how to be infected by the spittle or direct contact.It addition, systemic resistance power weakens, such as fatigue,
Suffer from cold and Smoking And Drinking is also excessively etc. the inducement of primary disease.This disease also can be secondary to flu or acute tonsillitis.
Additionally, acute pharyngitis recurrent exerbation or treatment be not thorough, and adjacent organs focus stimulates such as sinusitis, flat
Fructus Persicae body is scorching, and nasopharyngitis, tracheitis etc. also can develop into chronic pharyngitis.
For the treatment of chronic pharyngitis, doctor trained in Western medicine uses antibiotics mostly, conventional have penicillin pin,
Plug meter Song Zhen and Roxithromycin Tablets, amoxicillin tablets, Dobell's solution, nitrofural collutory etc..But it is difficult
With radical cure, and it is prone to repeatedly.Chinese medicine also has some effective prescriptions, with Xuanmai Ganju in treatment chronic pharyngitis
As a example by soup, it has certain curative effect in treatment pharyngitis, but the dosage that its side's medicine forms each Chinese medicine is bigger than normal, and uncomfortable
Close long-term taking.It addition, Radix Scrophulariae nature and flavor are sweet, bitter, salty in Fang, be slightly cold, taste are not good for person and easily cause stomach
Cold diarrhoea, limits its effect in treating pharyngitis.
The Chinese medicine compound effective dose of the present invention is little, and safety is high, to features such as the determined curative effects of chronic pharyngitis,
The dosage forms such as teabag, buccal tablet, chewing gum can be fabricated to, have a clear superiority in terms of preventing and treating chronic pharyngitis.
Summary of the invention
For above-mentioned situation, the purpose of the present invention is just to provide a kind of Chinese medicine compound of chronic pharyngitis of preventing and treating in treatment
Purposes in acute and chronic inflammation.
The present invention improves on the basis of XUANMAI GANJU TANG.Add Semen Oroxyli and be simultaneously used Radix Glycyrrhizae (processed with honey).
A kind of Chinese medicine compound, it is characterised in that its main active is made up of Radix Platycodonis, Radix Ophiopogonis, Semen Oroxyli, Radix Glycyrrhizae Preparata.
Described a kind of Chinese medicine compound, it is characterised in that described main active is by Radix Platycodonis 0.3g-15g, wheat
Winter 0.3g-15g, Semen Oroxyli 0.3g-15g, Radix Glycyrrhizae Preparata 0.3g-15g are constituted.
The preparation method of described a kind of Chinese medicine compound, it is characterised in that realize as follows, by Radix Platycodonis 0.3g-15
G, 0.3g-15g Radix Ophiopogonis, Semen Oroxyli 0.3g-15g, Radix Glycyrrhizae Preparata 0.3g-15g concentrate mixing through soak by water, it is thus achieved that
Finished product.
The application in preparation prevention or treatment chronic pharyngitis medicine of the described a kind of Chinese medicine compound.
It is specifically described:
Its technical scheme solved is, the preparation method of a kind of Chinese medicine compound, it is characterised in that real as follows
Existing: Radix Platycodonis 0.3g-15g, 0.3g-15g Radix Ophiopogonis, Semen Oroxyli 0.3g-15g, Radix Glycyrrhizae Preparata 0.3g-15g, take above
Four kinds of Chinese crude drugs, after three distilled water extraction, filter, merging filtrate, concentrate the filtrate to 120ml.Warp
Zoopery, have well ease pain, eliminate the phlegm, antitussive and antiinflammatory action.
Beneficial effect:
1, special because of chronic pharyngitis position, the cause of disease is complicated, and symptom is obstinate, and doctor trained in Western medicine uses Tri-Biocin mostly
Thing is treated, and conventional has penicillin pin, dexamethasone pin and Roxithromycin Tablets, amoxicillin tablets, compound recipe Borax
Solution, nitrofural collutory etc..But it is difficult to effect a radical cure, and is prone to repeatedly.XUANMAI GANJU TANG is in treatment pharyngitis
There is certain curative effect, but the dosage that its side's medicine forms each Chinese medicine is bigger than normal, is not suitable for long-term taking.It addition, Fang Zhongxuan
Nature and flavor are sweet, bitter, salty, be slightly cold for ginseng.Taste are not good for person and easily cause cold syndrome of the stomach diarrhoea, limit it and control in pharyngitis
Effect in treatment.
Prescription of the present invention is different from XUANMAI GANJU TANG prescription, and such as XUANMAI GANJU TANG can prevent and treat the disease of similar pharyngitis
Disease, its Chinese medicine composition includes Radix Scrophulariae, Radix Platycodonis, Radix Glycyrrhizae, Radix Ophiopogonis.The present invention compared with XUANMAI GANJU TANG, advantage
Being that odd-numbered day medication dose is little, long-term taking untoward reaction is little, is more suitable for patients with chronic pharyngitis long-term treatment and uses.
Additionally, the Semen Oroxyli in the party and Radix Glycyrrhizae (processed with honey), the clear throat of the side's of enhancing medicine, effect of removing heat from the lung and dissipating phlegm cough-relieving.
Accompanying drawing illustrates:
The phenol red standard curve of Fig. 1；
Four, detailed description of the invention
It is further elucidated with the present invention, it should be understood that these embodiments are merely to illustrate this below in conjunction with specific embodiment
Bright rather than limit the scope of the present invention, after reading this disclosure, those skilled in the art are to the present invention's
The amendment of the various equivalent form of values all falls within the application claims limited range.
XUANMAI GANJU TANG: Radix Scrophulariae 15 30g 6-12g Radix Ophiopogonis, Radix Glycyrrhizae 6-9g and Radix Platycodonis 6 12g, by above-mentioned former medicine
Material, after three distilled water extraction, filters, merging filtrate, concentrates the filtrate to 120ml.
Embodiment 1
Weigh Radix Platycodonis 0.4g, 5g Radix Ophiopogonis, Semen Oroxyli 3g, Radix Glycyrrhizae Preparata 12g respectively, by above-mentioned crude drug through three times
After distilled water extraction, filter, merging filtrate, concentrate the filtrate to 120ml.
Embodiment 2
Weigh Radix Platycodonis 0.3g, 0.3g Radix Ophiopogonis, Semen Oroxyli 0.3g, Radix Glycyrrhizae Preparata 0.3g respectively, by above-mentioned crude drug warp
After three distilled water extraction, filter, merging filtrate, concentrate the filtrate to 120ml.
Embodiment 3
Weigh Radix Platycodonis 2g, 7.6g Radix Ophiopogonis, Semen Oroxyli 10g, Radix Glycyrrhizae Preparata 3g respectively, by above-mentioned crude drug through three
After secondary distilled water extraction, filter, merging filtrate, concentrate the filtrate to 120ml.
Embodiment 4
Described Chinese medicine compound heavy dose respectively by Radix Platycodonis 15g, 15g Radix Ophiopogonis, Semen Oroxyli 15g, Radix Glycyrrhizae Preparata 15g,
By above-mentioned crude drug after three distilled water extraction, filter, merging filtrate, concentrate the filtrate to 120ml.
1, Chinese medicinal compound extract analgesic activity experimentation
Specific embodiments: Kunming mouse 50, body weight 18-22g, male and female half and half, is randomly divided into 5 groups,
Often group 10, is respectively blank group, positive drug group (aspirin), Xuanmai Ganju group (dosage
15g/kg), embodiment 1-4 group (dosage is respectively 3.4g/kg, 0.2g/kg, 3.77g/kg and 10g/kg).
Wherein positive drug group gavage aspirin, Xuanmai Ganju group gavage XUANMAI GANJU TANG is corresponding by reagent group gavage
Concentration by reagent, blank group gavage distilled water, continuous gavage 12 days, after being administered 1 hour the last time,
To the acetum 0.2ml/10g of the mice of each group lumbar injection 0.7% respectively, hiding of record mouse writhing
The number of times of writhing in phase and 15min, calculates writhing response suppression ratio.Experimental result is shown in Table 1.
Table 1 protects the effect of throat side's Dichlorodiphenyl Acetate induced mice writhing response
Compare with blank group, * P < 0.05, * * P < 0.01, lower same.
Experimental result: effect of the present invention is better than Xuanmai Ganju, with aspirin group close to showing that this Chinese medicine compound carries
Take thing and there is preferable analgesic activity.This result of study can reflect this Chinese medicinal compound extract to a certain extent
The pharyngalgia that pharyngitis causes can be prevented and treated.
2, Chinese medicinal compound extract phlegm-dispelling functions experimentation
Phenol red standard curve making: accurately weigh phenol red 0.5mg with analytical balance, add 50mg/ml's
NaHCO3Dissolve to 0.5ml, make containing phenol red amount 1mg/ml, as stock solution.Then with 50mg/ml's
NaHCO3Dilute successively, be made into every ml containing 1,2,3,4,5,6,7,8,9,10,15,20 μ g standard colorimetric tubes.Often manage
Capacity 3ml.The NaHCO of 50mg/ml3As blank, at wavelength 560nm, use ultraviolet spectrometry light
Degree meter colorimetric surveys OD value, and makes phenol red standard curve, and result is shown in Fig. 1.
Specific embodiments: Kunming mouse 50, body weight 18-22g, male and female half and half, the most blank group,
Positive drug group, Xuanmai Ganju group (dosage 15g/kg), (dosage is respectively 3.4 to embodiment 1-4
G/kg, 0.2g/kg, 3.77g/kg and 10g/kg).Wherein Xuanmai Ganju group gavage XUANMAI GANJU TANG, by reagent
Group gavage respective concentration by reagent, blank group gavage distilled water, continuous gavage 12 days.Before positive drug group
The ammonium chloride (1.0g/kg) of 7 days gavages 0.05g/ml after 5 days gavage distilled water.Each group is all before last is administered
Fasting can't help water 12 hours.30min after last administration, to the mice of each group lumbar injection 1% respectively
Phenol red normal saline solution 0.2ml/10g, after injection 30min, de-cervical vertebra is put to death.Separating trachea, trachea is inserted
Guan Bingyu syringe connects, and uses NaHCO3(50mg/ml) 0.5ml slowly injects tracheal strips, the most gently
Sucking-off, 4 times the most repeatedly, merges 4 irrigating solution about 2ml, and 1000rpm is centrifuged 5min, takes supernatant,
With spectrophotometric colo at wavelength 560nm, calculate phenol red amount according to phenol red standard curve.Experiment knot
Fruit is shown in Table 2.
The table 2 effect to airway of mice PSP
* P < 0.05, * * P < 0.01vs blank group.
Increase phenol red excretion and can reflect that drug dilution sputum promotes the ability of expectoration, test result indicate that: the present invention
Close with positive drug (ammonium chloride group) to the action effect of airway of mice PSP, it is the one of Xuanmai Ganju group
Times, the present invention can increase the excretion that airway of mice is phenol red, and the prompting present invention has preferable resolve phlegm effect.
3, Chinese medicinal compound extract antitussive effect experimentation
Kunming mouse 50, body weight 18-22g, male and female half and half, be randomly divided into blank group, positive drug group,
Xuanmai Ganju group (dosage 15g/kg), embodiment 1-4 (dosage be respectively 3.4g/kg, 0.2g/kg,
3.77g/kg and 10g/kg).Wherein positive drug group gavage carbetapentane citrate (0.5mg/ml), by reagent group respectively
The Chinese medicinal compound extract of gavage corresponding dosage, blank group gavage distilled water, continuous 12 days, the last time
After being administered 1h, in the 1000ml glass beaker tipped upside down on experiment table top, put into a cotton balls (on cotton balls
Drip 0.3ml 25% ammonia), then mice to be measured is put in the beaker of back-off, timing immediately, record mice
The number of times of cough in the time of the 1st cough (contraction of abdominal muscle is opened one's mouth) and 2min[2].Every animal is used
New ammonia cotton balls.
Experimental result shows, mice ammonia causes to cough in method experimental result such as table 2 below, version Mel and distilled water group
Compare P < 0.01, so carbetapentane citrate group has significant antitussive effect.The present invention all has significant antitussive to make
With.Experimental result is shown in Table 3 and table 4.
Ammonia is caused to cough the preclinical effect of mouse cough by table 3
* P < 0.05, * * P < 0.01vs blank group.
Table 4 is coughed in causing to cough mice 2min to ammonia the effect of number of times
* P < 0.05, * * P < 0.01vs blank group.
4, Chinese medicinal compound extract antiinflammatory action experimentation
Kunming mouse 50, body weight 18-22g, it is randomly divided into blank group, positive drug group (dosage
0.2g/kg), Xuanmai Ganju group (dosage 15g/kg), embodiment 1-4 (dosage be respectively 3.4g/kg,
0.2g/kg, 3.77g/kg and 10g/kg).Wherein positive drug group gavage aspirin, Xuanmai Ganju group gavage
XUANMAI GANJU TANG, by reagent group gavage respective concentration by reagent, blank group gavage distilled water, continuous 10 days,
Last be administered after 45min micro sample adding appliance draw dimethylbenzene (0.05ml/ is only) and drip in mouse right ear,
Animal is put to death after 15min.Auricle is taken along the punching of left and right auricle same area with the card punch of diameter 9mm.
Weigh respectively, using two auricle method of double differences values as the index of swelling degree.Relatively administration group and the difference of matched group,
And obtain swelling.
Experimental result: mouse corrosion disease exercising result shows, distilled water group ear swelling degree is 11.29 ± 3.77mg,
Aspirin, XUANMAI GANJU TANG, embodiment 1-4 all can alleviate Mus ear swelling rate, and protect throat side's effect and be better than
In XUANMAI GANJU TANG, Chinese medicine extract, heavy dose of.Throat side is protected in prompting the effect alleviating pharyngitis inflammation.Result
It is shown in Table 5.
Table 5 protects the effect of throat side's xylol induced mice auricle edema rate
* P < 0.05, vs blank group.
Embodiment 3 is investigated and is implemented Chinese medicinal compound extract maximum dosage-feeding mensuration
Kunming mouse 20, body weight 18-22g, male and female half and half, it is randomly divided into 2 groups, often group 10 (5
Female 5, male 5, sub-cage rearing), respectively Chinese medicinal compound extract (is obtained by embodiment 2 preparation
) Cmax medicinal liquid group (experimental group) and distilled water group (blank group).Before experiment, fasting 12h is (no
Prohibit water), all press 0.4ml/10g gastric infusion once for two groups.Recording and observe death condition, every day, body weight increased
Long situation, and the food-intake of mice every day, observed and recorded mice outward appearance sign, behavioral activity, the mental status,
Appetite, is had N/R secretion by hair, the colour of skin, breathing, defecation and color, and mouth and nose eye genitals etc.
Thing[1], Continuous Observation 14d.After 14d, de-neck is put to death, and dissects, its heart of perusal, liver, spleen, lung, kidney
And the major organs such as gastrointestinal tract, with or without obvious morphological changes of various tissue components.
Experimental result shows, to be grown up, body weight calculates for 60kg, and dosage is equivalent to clinical application amount of being grown up
240 times.After the extract of mouse stomach Cmax maximum volume, test mice outward appearance sign, behavior is lived
Dynamic, the mental status, appetite, defecation and color, by hair, the colour of skin, breathe all normal, the oral cavity reproduction of nose eye
The secretions the most without exception such as device.After dissection, two groups of mice visceras are the most normal.Group embodiment 2 mice and blank group are little
Body weight and the appetite of Mus compare no significant difference, refer to table 6.
Table 6 maximum dosage-feeding measures
Claims (4)
1. a Chinese medicine compound, it is characterised in that its main active is made up of Radix Platycodonis, Radix Ophiopogonis, Semen Oroxyli, Radix Glycyrrhizae Preparata.
A kind of Chinese medicine compound the most according to claim 1, it is characterised in that described main active is by Radix Platycodonis 0.3 g-15
G, g-15 g Radix Ophiopogonis 0.3, Semen Oroxyli 0.3 g-15 g, Radix Glycyrrhizae Preparata 0.3 g-15 g are constituted.
The preparation method of a kind of Chinese medicine compound the most according to claim 2, it is characterised in that realize as follows, by Radix Platycodonis 0.3
G-15 g, g-15 g Radix Ophiopogonis 0.3, Semen Oroxyli 0.3 g-15 g, Radix Glycyrrhizae Preparata 0.3 g-15 g concentrate mixing through soak by water, it is thus achieved that finished product.
A kind of Chinese medicine compound the most according to claim 1 and 2 application in preparation prevention or treatment chronic pharyngitis medicine.
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| CN108815370A (en) * | 2018-09-27 | 2018-11-16 | 杭州傅润堂生物科技有限公司 | A kind of clearing lung-heat tea for moistening and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101112412A (en) * | 2007-08-13 | 2008-01-30 | 张继孝 | Chinese traditional medicine formula for treating pharyngitis |
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| CN101112412A (en) * | 2007-08-13 | 2008-01-30 | 张继孝 | Chinese traditional medicine formula for treating pharyngitis |
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| Title |
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| 花君霞等: ""慢性咽炎中医治疗体会"", 《第15届全国中医耳鼻喉科学术研讨和继续教育年会论文汇编》 * |
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Application publication date: 20160817 |