CN105851054A - Pesticide composition containing fluazinam and fosthiazate - Google Patents

Abstract

The invention discloses a pesticide composition containing fluazinam and fosthiazate. The pesticide composition is prepared from the active components including fluazinam and fosthiazate and commonly-used auxiliary components, wherein the weight ratio of fluazinam to fosthiazate is 1:1-1:20. A large quantity of indoor and outdoor tests show that the pesticide composition has the significant synergistic interaction effect on multiple diseases, particularly root rot and the nematode disease which damage agricultural production; meanwhile, the pesticide dosage is decreased, the residual pesticide amount on crops is decreased, pollution to the environment is reduced, generation of the pesticide resistance of the diseases is delayed, and the service life of the pesticides is prolonged.

Description

A kind of containing fluazinam with the composition pesticide of fosthiazate

Technical field

The present invention relates to composition pesticide and application thereof, specifically with fluazinam and thiophene Azoles phosphine is the binary complex that active component is compounding, is mainly used in the anti-of disease on crops Control.

Background technology

Fluazinam (Fluazinam) is new substituted phenyl amines, wide-spectrum bactericide, acts on machine Reason is suppression pathogenic bacteria respiratory Mitochondria uncoupling agents.To causing Sclerotina Sclerotiorum in Winter Rape Core disease, the banded sclerotial blight of Oryza sativa L. and rice blast, wheat sharp eyespot, wheat scab, Semen Tritici aestivi white lead Disease, fruits and vegetables powdery mildew, downy mildew, gray mold, canker, dry rot, anthrax, The pathogen specially good effect of the diseases such as ring spot and spot defoliation, anthrachose of grape and skin fester disease.With benzo Imidazoles, dicarboximide class, succinate dehydrogenase inhibitors, electron transmission chain cpd The most existing antibacterial no interactions resistances such as III inhibitor and triazole type.To interlinkage The germ diseases such as spore genus, Phytophthora, Plasmopara, Sclerotinia and Venturia are also There is good activity.

Fosthiazate (Fosthiazate), belongs to organic phosphates nematicide, and the mechanism of action is The synthesis of suppression nematicide acetylcholinesterase；To root-knot nematode, root-rot (short body) nematicide, born of the same parents Capsule nematicide, Ditylenchus dipsaci etc. have specially good effect.Can be widely applied to vegetable, Fructus Musae, fruit tree, medical material etc. Crop.

The most long-time use continuously of pesticide easily produces resistance risk and consumption increases risk, And then increase cost and carrying capacity of environment, and filtered out by agriculture chemical compounding and there is notable Synergistic The compositions of effect, can not only reduce Pesticide use amount, reduce use cost, minimizing resistance wind Danger, moreover it is possible to reduce potential environmental risk.

Summary of the invention

It is desirable to provide it is a kind of containing fluazinam with the composition pesticide of fosthiazate, this combination Thing has significant synergistic function, can be used for multiple diseases on crops, especially root-rot The sick preventing and treating with nematicide.

Technical scheme: for achieving the above object, the present invention provides a kind of containing fluorine pyridine Amine and the composition pesticide of fosthiazate, it contains active component fluazinam and fosthiazate, fluazinam It is 1:1～1:20 with the weight ratio of fosthiazate；Active component fluazinam and fosthiazate are in compositions In gross weight percentage composition be 0.5%～80%, remaining is for allowing in pesticide to use and can connect The auxiliary element being subject to.

Described auxiliary element is solvent, emulsifying agent, wetting agent, dispersant, stabilizer, prevents Freeze agent, thickening agent, binding agent, disintegrating agent, defoamer, penetrating agent, macromolecule cyst material, Synergist, preservative and filler etc. are all conventional in pesticidal preparations or allow the composition used, Being not particularly limited, concrete composition and consumption are determined by test according to recipe requirements.

Composition pesticide of the present invention can be prepared as the multiple application forms being suitable for agriculturally using, Reasonable dosage form has microcapsule suspending agent, suspending agent, aqueous emulsion, microemulsion, granule, water Dispersible granule and wettable powder.

The production technology of the various application forms of described composition pesticide all belongs to existing known technology, Do not repeat them here.

Compared with prior art, it is an advantage of the current invention that:

1, fluazinam and fosthiazate compound and have significant synergistic function, than single dose list Solely use and significantly improve the prevention effect of disease on crops.

2, fluazinam and two kinds of active component of fosthiazate compound, and decrease Pesticide use amount, fall Low use cost, alleviates the pollution to environment.

3, fluazinam and two kinds of active component of fosthiazate compound, and the mechanism of action is different, make Increase with site, delayed the generation of disease drug resistance, added the service life of pesticide.

Detailed description of the invention

In order to be more fully understood that the essence of the present invention, below in conjunction with embodiment to present disclosure Being described further, but can not be considered as limitation of the present invention, the following stated is only used for explaining this Invention, for the amendment made without departing from present invention spirit and principle, replaces or improves, all belong to In the scope of protection of present invention.

Embodiment one:

Following material is all weight percentage: fluazinam 2%, fosthiazate 20%, carboxymethyl cellulose Element sodium 3%, poly-hexylamine lactone 2%, tetrahydrofurfuryl alcohol 10%, fatty acid methyl ester 10%, terminal hydroxy group Polyoxyethylene poly-oxygen propylene aether 5%, acrylate homopolymer sodium salt 3%, sodium hydroxide 2%, 1,2- Benzisothiazole-3-ketone 1%, deionized water complements to 100%.By above-mentioned active component, height Molecule cyst material, solvent mix, and make to be dissolved into homogeneous oil phase, in a shear condition, by oil Be added to containing emulsifying agent, dispersant, pH adjusting agent, preservative aqueous phase solution in, Surplus deionized water is supplied, and bi-material reacts at oil-water interfaces, forms high score ascus Wall, can be prepared by 22% fluazinam fosthiazate microcapsule suspending agent.

This embodiment is used for preventing and treating Roots of Peanut maize ear rot and nematicide: 22% fluazinam fosthiazate is micro- 1800g a.i./ha dilute root irrigation pressed by capsule suspending agent, and after medicine, 30d is to Semen arachidis hypogaeae root-rot Sick and nematicide preventive effect is respectively 93.49%, 91.63%；The fluazinam of 500g/L suspends 200g a.i./ha dilute root irrigation is pressed in agent, and after medicine, 30d is to Roots of Peanut maize ear rot and line The preventive effect of parasitosis is respectively 72.51%, 30.38%；20% Fosthiazate aqueous emulsion presses 2500g A.i./ha dilute root irrigation, after medicine, 30d is to Roots of Peanut maize ear rot and the preventive effect of nematicide It is respectively 27.68%, 77.35%.Visible, collaborative after fluazinam and fosthiazate binary built Potentiation is notable, and the lasting period is long, is significantly better than each to the preventive effect of Roots of Peanut maize ear rot and nematicide Single dose is used alone, and meanwhile, does not finds that Semen arachidis hypogaeae is produced by this binary built medicament in process of the test Crude drug evil.

Embodiment two:

Following material is all weight percentage: fluazinam 3%, fosthiazate 30%, alkyl phenol polyoxy Vinyl ethers formaldehyde condensation products sulfate 10%, triphen ethyl phenol polyoxyethylene ether phosphate 5%, Acrylate homopolymer sodium salt 5%, propylene glycol 3%, carboxymethyl cellulose 1.5%, tributyl phosphate 0.2%, deionized water supplies 100%.By above-mentioned active component, wetting agent, dispersant, prevent Freeze agent, thickening agent and defoamer sand milling in high speed shear dispersion, sand mill, at water-medium The high dispersive of middle formation, stable suspension system, can be prepared by 33% fluazinam fosthiazate and hang Floating agent.

This embodiment is used for preventing and treating Fusarium solani and nematicide: 33% fluazinam fosthiazate hangs 1800g a.i./ha dilute root irrigation press in floating agent, after medicine 30d to Fusarium solani with The preventive effect of nematicide is respectively 96.69%, 91.42%；The fluazinam suspending agent of 500g/L is pressed 200g a.i./ha dilute root irrigation, after medicine, 30d is to Fusarium solani and nematicide Preventive effect be respectively 72.58%, 33.46%；20% Fosthiazate aqueous emulsion presses 2500g a.i./ha Dilute root irrigation, after medicine, the preventive effect of Fusarium solani and nematicide is respectively by 30d 28.39%, 78.62%.Visible, synergistic function after fluazinam and fosthiazate binary built Significantly, the lasting period is long, independent significantly better than each single dose to the preventive effect of Fusarium solani and nematicide Use, meanwhile, in process of the test, do not find that this binary built medicament produces poisoning to Fructus Capsici.

Embodiment three:

Following material is all weight percentage: fluazinam 3%, fosthiazate 42%, trimethylbenzene 10%, Tetrahydrofurfuryl alcohol 5%, polyol fatty acid ester and ethylene oxide adduct 10% thereof, p-hydroxyphenyl wood Quality sulfonate sodium 3%, the formaldehyde condensation products 3% of methyl naphthalene sulfonic acid sodium, epoxychloropropane 1%, HPMC 2%, glycerol 1%, deionized water supplies 100%.Above-mentioned activity is become Point, solvent, emulsifying agent, dispersant, stabilizer and thickening agent be mixed to form oil phase, antifreezing agent Water dissolves and forms aqueous phase, slowly oil phase is added in aqueous phase under cutter effect, and continue Continuous shearing about 30 minutes, prepares the fluazinam Fosthiazate aqueous emulsion of 45%.

This embodiment is used for preventing and treating Tobacco Root maize ear rot and nematicide: 45% fluazinam fosthiazate water 1800g a.i./ha dilute root irrigation pressed by Emulsion, after medicine 30d to Tobacco Root maize ear rot and The preventive effect of nematicide is respectively 95.37%, 96.12%；The fluazinam suspending agent of 500g/L is pressed 200g a.i./ha dilute root irrigation, after medicine, 30d is to Tobacco Root maize ear rot and nematicide Preventive effect be respectively 73.45%, 24.63%；20% Fosthiazate aqueous emulsion presses 2500g a.i./ha Dilute root irrigation, after medicine, the preventive effect of Tobacco Root maize ear rot and nematicide is respectively by 30d 29.68%, 75.24%.Visible, synergistic function after fluazinam and fosthiazate binary built Significantly, the lasting period is long, independent significantly better than each single dose to the preventive effect of Tobacco Root maize ear rot and nematicide Use, meanwhile, in process of the test, do not find that this binary built medicament produces poisoning to Nicotiana tabacum L..

Embodiment four:

Following material is all weight percentage: fluazinam 5%, fosthiazate 45%, trimethylbenzene 10%, Tetrahydrofurfuryl alcohol 5%, triphen ethyl phenol polyoxyethylene groups ether phosphate 10%, triphenyl phosphite 1%, organosilicon 1%, propyl isome 2%, hydroxymethyl cellulose 2%, deionized water supplies 100%. Active component solvent is completely dissolved, then add emulsifying agent, stabilizer, penetrating agent, Synergist, thickening agent mix homogeneously, be eventually adding deionized water, after being sufficiently stirred for, can make Obtain the fluazinam fosthiazate microemulsion of 50%.

This embodiment is used for preventing and treating root rot and nematicide: 50% fluazinam fosthiazate is micro- 1800g a.i./ha dilute root irrigation pressed by Emulsion, after medicine 30d to root rot and The preventive effect of nematicide is respectively 93.86%, 98.41%；The fluazinam suspending agent of 500g/L is pressed 200g a.i./ha dilute root irrigation, after medicine, 30d is to root rot and nematicide Preventive effect be respectively 74.17%, 22.92%；20% Fosthiazate aqueous emulsion presses 2500g a.i./ha Dilute root irrigation, after medicine, the preventive effect of root rot and nematicide is respectively by 30d 31.05%, 71.34%.Visible, synergistic function after fluazinam and fosthiazate binary built Significantly, the lasting period is long, independent significantly better than each single dose to the preventive effect of root rot and nematicide Use, meanwhile, in process of the test, do not find that this binary built medicament produces poisoning to Semen sojae atricolor.

Embodiment five:

Following material is all weight percentage: fluazinam 0.2%, fosthiazate 2.3%, secondary alkyl Sodium sulfate 10%, terminal hydroxy group polyoxyethylene poly-oxygen propylene aether block copolymer 10%, three phenethyl Phenol polyethenoxy ether phosphate 15%, carboxymethyl cellulose 5%, fine particle calcium carbonate 5%, Kaolin is supplied To 100%.By blended to above-mentioned active component, wetting agent, dispersant, binding agent and filler Add water and mediate, use pinch-out granulator pinch out and shape, afterwards granule fluid bed is done Dry, screening, can be prepared by 2.5% fluazinam fosthiazate granule.

This embodiment is used for preventing and treating bird watching root rot and nematicide: 2.5% fluazinam thiazole Phosphine granule spreads fertilizer over the fields process by 1800g a.i./ha, after medicine 30d to bird watching root rot and The preventive effect of nematicide is respectively 90.26%, 93.85%；The fluazinam suspending agent of 500g/L is pressed 200g a.i./ha dilute root irrigation, after medicine, 30d is to bird watching root rot and line The preventive effect of parasitosis is respectively 77.89%, 26.38%；20% Fosthiazate aqueous emulsion presses 2500g A.i./ha dilute root irrigation, after medicine, 30d is to bird watching root rot and nematicide Preventive effect is respectively 28.36%, 76.81%.Visible, after fluazinam and fosthiazate binary built Obvious synergy, the lasting period is long, bright to the preventive effect of bird watching root rot and nematicide Aobvious it be better than each single dose and be used alone, meanwhile, process of the test does not finds this binary built medicament Bird watching is produced poisoning.

Embodiment six:

Following material is all weight percentage: fluazinam 5%, fosthiazate 65%, secondary alkylsurfuric acid Sodium 5%, acrylate homopolymer sodium salt 5%, low-substituted hydroxypropyl cellulose 5%, white carbon 5%, Kaolin supplies 100%.By above-mentioned effective ingredient, wetting agent, dispersant, disintegrating agent with fill out Material mix homogeneously, pulverizes with micro jet, through mediating, is subsequently adding fluidized bed prilling Drying machine carries out pelletize, dry, screening, can be prepared by 70% fluazinam fosthiazate moisture Shot agent.

This embodiment is used for preventing and treating Radix Ginseng maize ear rot and nematicide: 70% fluazinam fosthiazate water Dispersible granule presses 1800g a.i./ha dilute root irrigation, and after medicine, 30d is to Radix Ginseng root-rot Sick and nematicide preventive effect is respectively 95.81%, 91.42%；The fluazinam of 500g/L suspends 200g a.i./ha dilute root irrigation is pressed in agent, and after medicine, 30d is to Radix Ginseng maize ear rot and line The preventive effect of parasitosis is respectively 79.36%, 24.13%；20% Fosthiazate aqueous emulsion presses 2500g A.i./ha dilute root irrigation, after medicine, 30d is to Radix Ginseng maize ear rot and the preventive effect of nematicide It is respectively 25.12%, 78.13%.Visible, collaborative after fluazinam and fosthiazate binary built Potentiation is notable, and the lasting period is long, is significantly better than each to the preventive effect of Radix Ginseng maize ear rot and nematicide Single dose is used alone, and meanwhile, does not finds that Radix Ginseng is produced by this binary built medicament in process of the test Crude drug evil.

Embodiment seven:

Following material is all weight percentage: fluazinam 5%, fosthiazate 70%, secondary alkylsurfuric acid Sodium 5%, alkyl phenol resin polyoxyethylene ether sulfate 5%, triphen ethyl phenol polyoxyethylene ether phosphorus Acid esters 5%, white carbon 5%, kieselguhr supplies 100%.By above-mentioned by effective ingredient, wetting agent, Dispersant and filler mixing, again through comminution by gas stream, mix homogeneously after mechanical activation comminution, can be prepared by 75% fluazinam fosthiazate wettable powder.

This embodiment is used for preventing and treating notoginseng root rot and nematicide: 75% fluazinam fosthiazate can WP presses 1800g a.i./ha dilute root irrigation, and after medicine, 30d is to Radix Notoginseng root-rot Sick and nematicide preventive effect is respectively 92.54%, 90.66%；The fluazinam of 500g/L suspends 200g a.i./ha dilute root irrigation is pressed in agent, and after medicine, 30d is to notoginseng root rot and line The preventive effect of parasitosis is respectively 73.24%, 32.67%；20% Fosthiazate aqueous emulsion presses 2500g A.i./ha dilute root irrigation, after medicine, 30d is to notoginseng root rot and the preventive effect of nematicide It is respectively 21.96%, 79.34%.Visible, collaborative after fluazinam and fosthiazate binary built Potentiation is notable, and the lasting period is long, is significantly better than each to the preventive effect of notoginseng root rot and nematicide Single dose is used alone, and meanwhile, does not finds that Radix Notoginseng is produced by this binary built medicament in process of the test Crude drug evil.

Embodiment eight: fluazinam and the compounding Toxicity Determination examination to Semen arachidis hypogaeae stalk maize ear rot of fosthiazate Test.

Test method is with reference to " antibacterial indoor bioassay test rule NY/T 1156.2-2006 ", use mycelial growth rate method.Synergism is judged by co-toxicity coefficient method, Co-toxicity coefficient (CTC) >=120 shows as potentiation；Co-toxicity coefficient (CTC)≤80 shows For antagonism；80 ＜ co-toxicity coefficient (CTC) ＜ 120 show as summation action.

Table 1, fluazinam and the fosthiazate indoor joint toxicity measuring result to Semen arachidis hypogaeae stalk maize ear rot

Medicament title and proportioning (weight ratio)	EC50(mg/L)	ATI	TTI	CTC
					Fluazinam	1.06	100.00	-	-
Fosthiazate	73.41	1.44	-	-
					Fluazinam: fosthiazate (1:1)	1.54	68.83	50.72	135.71
Fluazinam: fosthiazate (1:3)	2.49	42.57	26.08	163.23
					Fluazinam: fosthiazate (1:7)	4.17	25.42	13.76	184.74
Fluazinam: fosthiazate (1:10)	4.73	22.41	10.40	215.48
					Fluazinam: fosthiazate (1:15)	7.68	13.80	7.60	181.58
Fluazinam: fosthiazate (1:20)	10.96	9.67	6.13	157.75

As it can be seen from table 1 fluazinam and fosthiazate are at the ratio of 1:1～1:20 (by weight) When compounding in the range of example, co-toxicity coefficient (CTC) is all higher than 120, and Semen arachidis hypogaeae is obstructed the equal table of maize ear rot Revealing synergistic function, especially fluazinam and fosthiazate compounds with 1:10 (by weight), Synergistic function is the most notable, and co-toxicity coefficient (CTC) is 215.48.Visible, fluazinam Compounding with fosthiazate have reasonability and feasibility.

Embodiment nine: fluazinam and the compounding Toxicity Determination to Fructus Capsici nematicide of fosthiazate are tried Test.

Test method: first take the Fructus Capsici root system producing a large amount of root knots, rinse gently with tap water Totally, then with the milky egg capsule on dissecting needle gently picking old complaint, put into diameter 6cm's In little culture dish, add a small amount of sterilized water, 25 DEG C of calorstats are hatched 3～4d, collects 2 Instar larvae, and add sterilized water and be configured to the outstanding of finite concentration (500/about ml) Supernatant liquid is standby.

Set 5 Concentraton gradient to process, with sterilized water as blank.Take 96 porocyte trainings Supporting plate, every hole adds medicament 150 microlitre of the variable concentrations prepared, and adds isopyknic line Worm suspension, under the conditions of 25 DEG C, moisturizing is cultivated, the amount of survival of 48h microscopy nematicide after treatment With dead quantity, nematicide is stiff motionless for dead worm, and nematicide is the worm that lives in bending wriggling state. Calculate mortality rate and corrected mortality.

Carry out statistical analysis with DPS statistical analysis software, calculate the EC of each medicament₅₀, and according to Judge that synergism, co-toxicity coefficient (CTC) >=120 show as potentiation and make by co-toxicity coefficient method With；Co-toxicity coefficient (CTC)≤80 shows as antagonism；80 ＜ co-toxicity coefficients (CTC) ＜ 120 shows as summation action.

Table 2, fluazinam and the fosthiazate indoor joint toxicity measuring result to Fructus Capsici nematicide

From table 2 it can be seen that fluazinam and fosthiazate are at the ratio of 1:1～1:20 (by weight) When compounding in the range of example, co-toxicity coefficient (CTC) is all higher than 120, table equal to Fructus Capsici nematicide Revealing synergistic function, especially fluazinam and fosthiazate compounds with 1:10 (by weight), Synergistic function is the most notable, and co-toxicity coefficient (CTC) is 231.84.Visible, fluazinam Compounding with fosthiazate have reasonability and feasibility.

In sum, what the present invention provided is a kind of containing fluazinam with the pesticide combination of fosthiazate Thing, obvious synergy, compared with existing unitary agent, multiple on crops The prevention effect of disease, especially root rot and nematicide significantly improves, to crop safety, value Obtain popularization and application in agricultural production.

Claims (4)

1. one kind contains fluazinam and the composition pesticide of fosthiazate, it is characterised in that: include The weight ratio of active component fluazinam and fosthiazate, fluazinam and fosthiazate is 1:1～1:20.

The most according to claim 1 a kind of containing fluazinam with the pesticide combination of fosthiazate Thing, it is characterised in that: fluazinam and fosthiazate gross weight percentage composition in the composition is 0.5%～80%, remaining is to use and receptible auxiliary element in pesticide.

The most according to claim 1 and 2 a kind of containing fluazinam with the pesticide of fosthiazate Compositions, it is characterised in that: the dosage form of described composition pesticide be microcapsule suspending agent, suspending agent, One in aqueous emulsion, microemulsion, granule, water dispersible granules and wettable powder.

4. a kind of composition pesticide containing fluazinam and fosthiazate described in claim 1 exists Application in root rot and nematicide on preventing and treating crops.