CN105848771B - 高速离心式混合装置和使用方法 - Google Patents

高速离心式混合装置和使用方法 Download PDF

Info

Publication number
CN105848771B
CN105848771B CN201480058443.4A CN201480058443A CN105848771B CN 105848771 B CN105848771 B CN 105848771B CN 201480058443 A CN201480058443 A CN 201480058443A CN 105848771 B CN105848771 B CN 105848771B
Authority
CN
China
Prior art keywords
pulley
tank
axis
shaft
mixing device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201480058443.4A
Other languages
English (en)
Chinese (zh)
Other versions
CN105848771A (zh
Inventor
史蒂文·霍夫曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tyme Inc
Original Assignee
Tyme Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tyme Inc filed Critical Tyme Inc
Publication of CN105848771A publication Critical patent/CN105848771A/zh
Application granted granted Critical
Publication of CN105848771B publication Critical patent/CN105848771B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F29/00—Mixers with rotating receptacles
    • B01F29/80—Mixers with rotating receptacles rotating about a substantially vertical axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F29/00—Mixers with rotating receptacles
    • B01F29/15—Use of centrifuges for mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/60—Mixing solids with solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F29/00—Mixers with rotating receptacles
    • B01F29/10—Mixers with rotating receptacles with receptacles rotated about two different axes, e.g. receptacles having planetary motion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F29/00—Mixers with rotating receptacles
    • B01F29/30—Mixing the contents of individual packages or containers, e.g. by rotating tins or bottles
    • B01F29/32—Containers specially adapted for coupling to rotating frames or the like; Coupling means therefor
    • B01F29/322—Containers specially adapted for coupling to rotating frames or the like; Coupling means therefor of two or more containers supported for simultaneous mixing, e.g. for bottles in crates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/25—Mixers with loose mixing elements, e.g. loose balls in a receptacle
    • B01F33/251—Mixers with loose mixing elements, e.g. loose balls in a receptacle using balls as loose mixing element
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
  • Accessories For Mixers (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
CN201480058443.4A 2013-10-22 2014-10-21 高速离心式混合装置和使用方法 Expired - Fee Related CN105848771B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/059,837 US9724657B2 (en) 2013-10-22 2013-10-22 High-speed centrifugal mixing devices and methods of use
US14/059,837 2013-10-22
PCT/US2014/061481 WO2015061256A1 (en) 2013-10-22 2014-10-21 High-speed centrifugal mixing devices and methods of use

Publications (2)

Publication Number Publication Date
CN105848771A CN105848771A (zh) 2016-08-10
CN105848771B true CN105848771B (zh) 2018-07-10

Family

ID=52826365

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480058443.4A Expired - Fee Related CN105848771B (zh) 2013-10-22 2014-10-21 高速离心式混合装置和使用方法

Country Status (13)

Country Link
US (2) US9724657B2 (https=)
EP (1) EP3060331A4 (https=)
JP (1) JP7117078B2 (https=)
KR (1) KR20160074580A (https=)
CN (1) CN105848771B (https=)
AU (1) AU2014340327B2 (https=)
BR (1) BR112016009041B1 (https=)
CA (1) CA2927979C (https=)
IL (1) IL245174B (https=)
MX (1) MX380524B (https=)
PH (1) PH12016500730B1 (https=)
WO (1) WO2015061256A1 (https=)
ZA (1) ZA201602769B (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9724657B2 (en) * 2013-10-22 2017-08-08 Tyme, Inc. High-speed centrifugal mixing devices and methods of use
US9585841B2 (en) 2013-10-22 2017-03-07 Tyme, Inc. Tyrosine derivatives and compositions comprising them
DE102015100613A1 (de) * 2015-01-16 2016-07-21 Andreas Hettich Gmbh & Co. Kg Rotor einer Dualen Zentrifuge
US9907319B2 (en) * 2015-03-13 2018-03-06 Steak 'n Shake Enterprises, Inc. Dual-axis rotational mixer for food products
ES2928773T3 (es) 2017-01-17 2022-11-22 Heparegenix Gmbh Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos
PH12021552866A1 (en) 2019-05-14 2022-11-07 Tyme Inc Compositions and methods for treating cancer
CN110952057A (zh) * 2019-12-04 2020-04-03 青岛大成索具有限公司 一种用于热镀锌产线的离心脱料装置
US10905698B1 (en) 2020-05-14 2021-02-02 Tyme, Inc. Methods of treating SARS-COV-2 infections
ES3052725T3 (en) * 2021-03-16 2026-01-13 Swissmeca Sa Sample tube and method for dispersing and homogenizing
CN113145319B (zh) * 2021-04-30 2022-03-08 江苏汉典生物科技股份有限公司 一种益生菌粉的制备工艺
CN113413803A (zh) * 2021-06-22 2021-09-21 吉林建筑大学 一种用于微生物矿化培养基的配置装置
WO2024263948A1 (en) * 2023-06-22 2024-12-26 The Soluble Oak Social Purpose Corporation Extraction of soluble wood compounds

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1011929A (en) * 1908-12-12 1911-12-19 Frederic Ecaubert Mixing and separating machine.
US2961703A (en) * 1957-07-16 1960-11-29 Kimble Glass Co Centrifugal molding apparatus
US3591098A (en) * 1969-02-11 1971-07-06 Robert C Mcshirley Dental amalgam preparing apparatus
GB1387402A (en) * 1971-03-02 1975-03-19 Techno Med Ltd Mixing process and apparatus
JPS58183248U (ja) * 1982-05-31 1983-12-06 楠　真澄 連続式遠心粉砕機
US4586292A (en) * 1985-01-30 1986-05-06 The United States Of America As Represented By The United States Department Of Energy Machine imparting complex rotary motion for lapping a spherical inner diameter
JP2668880B2 (ja) * 1987-06-23 1997-10-27 日本油脂株式会社 被覆アミノ酸類の製造方法
DE8907335U1 (de) 1989-06-15 1990-10-18 Espe Stiftung & Co Produktions- und Vertriebs KG, 8031 Seefeld Mischvorrichtung für Pasten
US5029760A (en) 1989-10-26 1991-07-09 Gamblin Rodger L Centrifugal grinding and mixing apparatus
JPH0642936B2 (ja) * 1989-12-22 1994-06-08 株式会社クボタ 混合機
JPH04135161A (ja) * 1990-09-21 1992-05-08 Ietatsu Ono 研磨方法とその研磨加工装置
US5355638A (en) * 1992-09-08 1994-10-18 Hoffman Steve E Traction drive centrifugal finisher
DE4239284A1 (de) * 1992-11-23 1994-05-26 Hilti Ag Mischgerät für fließfähige Massen
US5531637A (en) 1993-05-14 1996-07-02 Kabushiki Kaisha Nagao Kogyo Automatic centrifugal fluidizing barrel processing apparatus
US6086242A (en) * 1998-02-27 2000-07-11 University Of Utah Dual drive planetary mill
JP4084493B2 (ja) * 1999-03-25 2008-04-30 株式会社シンキー 攪拌脱泡装置
US6361486B1 (en) * 2000-02-29 2002-03-26 Agilent Technologies, Inc. Coaxial-drive centrifuge providing tilt control relative to centrifugal force
JP4347989B2 (ja) 2000-03-31 2009-10-21 株式会社シンキー 攪拌脱泡装置及び被混練材料の攪拌脱泡方法
JP2001340709A (ja) * 2000-06-05 2001-12-11 Asahi Chem Res Lab Ltd 高粘性流動体の濾過方法及び装置
JP2002196006A (ja) * 2000-12-27 2002-07-10 Olympus Optical Co Ltd 自動分析装置
JP4303904B2 (ja) * 2001-09-17 2009-07-29 ミナミ株式会社 ラミネートチューブ入り半田攪拌機
US6863207B2 (en) * 2001-09-27 2005-03-08 Mikronite Technologies Group Inc. System for high speed centrifugal welding
JP3468367B2 (ja) * 2001-12-03 2003-11-17 株式会社ジーシー 歯牙修復材用カプセル用練和装置
JP4068981B2 (ja) * 2003-02-12 2008-03-26 株式会社シンキー 攪拌脱泡装置
JP3919773B2 (ja) * 2003-08-21 2007-05-30 浩三 藤田 殺菌方法及び粉砕殺菌装置
DE10360526A1 (de) * 2003-12-22 2005-07-14 Roche Diagnostics Gmbh Reagenzkassette mit Reagenzbehälter für partikelhaltiges Reagenz für dessen noninvasive Homogenisierung
JP2006006372A (ja) * 2004-06-22 2006-01-12 Gc Corp 歯牙修復材用練和装置
JP4937502B2 (ja) * 2004-08-04 2012-05-23 有限会社ナガオシステム 遊星ボールミル
EP1674081A1 (de) 2004-12-23 2006-06-28 KTB Tumorforschungsgesellschaft mbH Herstellung von lipidbasierten Nanopartikeln unter Einsatz einer dualen asymmetrischen Zentrifuge
JP4130956B2 (ja) * 2005-04-08 2008-08-13 ワタナベ株式会社 遊星運動式真空撹拌脱泡装置
US20070002682A1 (en) * 2005-06-29 2007-01-04 Bausch & Lomb Incorporated Method of producing liquid solutions comprising fusible solid materials
JP5378656B2 (ja) * 2007-04-23 2013-12-25 株式会社シンキー 撹拌脱泡装置
WO2009020167A1 (ja) 2007-08-08 2009-02-12 Thinky Corporation 攪拌脱泡装置およびそれに用いる容器
JP4188411B1 (ja) 2008-05-12 2008-11-26 株式会社シンキー 攪拌脱泡装置の停止方法及び攪拌脱泡装置
JP2010274171A (ja) * 2009-05-27 2010-12-09 Tetsudo Nagayama 公転・自転撹拌機
JP2011050814A (ja) 2009-08-31 2011-03-17 Thinky Corp 攪拌脱泡装置
JP5357809B2 (ja) * 2010-03-08 2013-12-04 株式会社シンキー 誘導電流発生器、回転センサ、及び、攪拌脱泡装置
JP5719586B2 (ja) * 2010-06-08 2015-05-20 株式会社マルコム 真空混練脱泡装置
JP5418919B2 (ja) * 2011-03-23 2014-02-19 株式会社栗本鐵工所 遊星ボールミル
WO2012130254A1 (en) * 2011-03-28 2012-10-04 Haldor Topsøe A/S Mixing device
US20130183263A1 (en) * 2012-01-17 2013-07-18 Steven Hoffman Pharmaceutical compositions and methods
US8481498B1 (en) * 2012-01-17 2013-07-09 Steven Hoffman Pharmaceutical compositions and methods
PL2804599T3 (pl) 2012-01-17 2019-06-28 Tyme, Inc. Terapia skojarzona do leczenia nowotworu złośliwego
US9724657B2 (en) * 2013-10-22 2017-08-08 Tyme, Inc. High-speed centrifugal mixing devices and methods of use
JP6798777B2 (ja) * 2015-10-23 2020-12-09 株式会社写真化学 攪拌・脱泡方法および攪拌・脱泡装置
EP4031273B1 (en) * 2019-09-19 2025-01-29 Flacktek, Inc. Rotation mixer with improved belt drive

Also Published As

Publication number Publication date
IL245174A0 (en) 2016-06-30
JP2016537187A (ja) 2016-12-01
ZA201602769B (en) 2017-04-26
AU2014340327B2 (en) 2018-10-04
BR112016009041A2 (https=) 2017-08-01
US20170296990A1 (en) 2017-10-19
NZ719452A (en) 2021-03-26
PH12016500730B1 (en) 2020-02-14
EP3060331A4 (en) 2017-12-13
CA2927979A1 (en) 2015-04-30
US20150110735A1 (en) 2015-04-23
WO2015061256A1 (en) 2015-04-30
MX380524B (es) 2025-03-12
CA2927979C (en) 2020-03-24
IL245174B (en) 2020-10-29
BR112016009041B1 (pt) 2022-05-17
MX2016005165A (es) 2016-12-14
US11097234B2 (en) 2021-08-24
PH12016500730A1 (en) 2016-05-30
CN105848771A (zh) 2016-08-10
US9724657B2 (en) 2017-08-08
AU2014340327A1 (en) 2016-05-19
JP7117078B2 (ja) 2022-08-12
EP3060331A1 (en) 2016-08-31
KR20160074580A (ko) 2016-06-28

Similar Documents

Publication Publication Date Title
CN105848771B (zh) 高速离心式混合装置和使用方法
Preta New insights into targeting membrane lipids for cancer therapy
JP2016537187A5 (https=)
Yaghmur et al. Characterization of bupivacaine-loaded formulations based on liquid crystalline phases and microemulsions: the effect of lipid composition
Park et al. Current status of supersaturable self-emulsifying drug delivery systems
Negrini et al. pH-responsive lyotropic liquid crystals for controlled drug delivery
Fernández‐Varo et al. Bespoken nanoceria: an effective treatment in experimental hepatocellular carcinoma
Khan et al. Nanostructured lipid carriers: An emerging platform for improving oral bioavailability of lipophilic drugs
Nunes et al. NSAIDs interactions with membranes: a biophysical approach
Kucerka et al. Cholesterol in bilayers with PUFA chains: doping with DMPC or POPC results in sterol reorientation and membrane-domain formation
Zhou et al. Release of polyphenolic drugs from dynamically bonded layer-by-layer films
CA2797913C (en) High shear application in medical therapy
US20090281663A1 (en) Device and method for mixing materials
KR20150038178A (ko) 분말 공급 장치
Zhai et al. Self-assembled lyotropic liquid crystalline phase behavior of monoolein–capric acid–phospholipid nanoparticulate systems
AU2022248850A1 (en) Compositions having improved bioavailability of therapeutics
Rao et al. Pluronic-functionalized silica–lipid hybrid microparticles: improving the oral delivery of poorly water-soluble weak bases
Song et al. Cerasomal lovastatin nanohybrids for efficient inhibition of triple-negative breast cancer stem cells to improve therapeutic efficacy
JP7698896B2 (ja) プテロスチルベンの共結晶及びそれらを含む組成物
Golubovic-Liakopoulos et al. Nanotechnology use with cosmeceuticals
JP2006006372A (ja) 歯牙修復材用練和装置
Patel et al. Formulation and evaluation of bioadhesive buccal drug delivery of repaglinide tablets
Sakellari et al. The role of lipid particle-laden interfaces in regulating the co-delivery of two hydrophobic actives from o/w emulsions
NZ719452B2 (en) High-speed centrifugal mixing devices and methods of use
Sigfridsson et al. Evaluation of systemic exposure of nanoparticle suspensions subcutaneously administered to mice regarding stabilization, volume, location, concentration and size

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20180710

CF01 Termination of patent right due to non-payment of annual fee