CN105848679A - 脑信号蛋白-4d结合分子治疗动脉粥样硬化的用途 - Google Patents

脑信号蛋白-4d结合分子治疗动脉粥样硬化的用途 Download PDF

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Publication number
CN105848679A
CN105848679A CN201480067853.5A CN201480067853A CN105848679A CN 105848679 A CN105848679 A CN 105848679A CN 201480067853 A CN201480067853 A CN 201480067853A CN 105848679 A CN105848679 A CN 105848679A
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sema4d
antibody
binding
methods
binding molecule
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Chinese (zh)
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M·左德勒
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Vaccinex Inc
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Vaccinex Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201480067853.5A 2013-10-10 2014-10-10 脑信号蛋白-4d结合分子治疗动脉粥样硬化的用途 Pending CN105848679A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361889421P 2013-10-10 2013-10-10
US61/889,421 2013-10-10
PCT/US2014/060129 WO2015054628A1 (en) 2013-10-10 2014-10-10 Use of semaphorin-4d binding molecules for treatment of atherosclerosis

Publications (1)

Publication Number Publication Date
CN105848679A true CN105848679A (zh) 2016-08-10

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CN201480067853.5A Pending CN105848679A (zh) 2013-10-10 2014-10-10 脑信号蛋白-4d结合分子治疗动脉粥样硬化的用途

Country Status (18)

Country Link
US (1) US9512224B2 (enrdf_load_stackoverflow)
EP (1) EP3054976B1 (enrdf_load_stackoverflow)
JP (2) JP6760840B2 (enrdf_load_stackoverflow)
KR (1) KR102366682B1 (enrdf_load_stackoverflow)
CN (1) CN105848679A (enrdf_load_stackoverflow)
AU (1) AU2014331683B2 (enrdf_load_stackoverflow)
BR (1) BR112016008010A2 (enrdf_load_stackoverflow)
CA (1) CA2926944C (enrdf_load_stackoverflow)
DK (1) DK3054976T3 (enrdf_load_stackoverflow)
EA (1) EA037551B1 (enrdf_load_stackoverflow)
ES (1) ES2821814T3 (enrdf_load_stackoverflow)
IL (1) IL244976B (enrdf_load_stackoverflow)
MX (1) MX385575B (enrdf_load_stackoverflow)
NZ (1) NZ630881A (enrdf_load_stackoverflow)
PT (1) PT3054976T (enrdf_load_stackoverflow)
SG (1) SG11201602807PA (enrdf_load_stackoverflow)
WO (1) WO2015054628A1 (enrdf_load_stackoverflow)
ZA (1) ZA201602577B (enrdf_load_stackoverflow)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106474559A (zh) * 2016-11-30 2017-03-08 西南交通大学 一种在心血管植入材料表面构建Sema 4D/Heparin微环境的方法
CN106983919A (zh) * 2017-03-06 2017-07-28 西南交通大学 一种Sema 4D‑VEGF涂层的构建方法及应用
CN110325213A (zh) * 2017-02-22 2019-10-11 瓦西尼斯公司 神经退行性或神经炎性疾病中胶质细胞活化的早期检测
WO2020083007A1 (zh) * 2018-10-22 2020-04-30 华中科技大学同济医学院附属协和医院 Sema4D/PlexinB1抑制剂在制备治疗及预防眼底血管疾病药物中的应用
CN116949097A (zh) * 2023-09-20 2023-10-27 江苏集萃药康生物科技股份有限公司 一种sema4d人源化小鼠模型的构建方法及其应用

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US9708601B2 (en) 2012-04-26 2017-07-18 Vaccinex, Inc. Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus
US10494440B2 (en) 2012-05-11 2019-12-03 Vaccinex, Inc. Use of semaphorin-4D binding molecules to promote neurogenesis following stroke
MX377858B (es) 2013-06-25 2025-03-11 Vaccinex Inc Combinación de moleculas inhibidoras de semaforina-4d con agentes inmunomoduladores y usos de los mismos.
NZ630881A (en) 2013-10-10 2016-03-31 Vaccinex Inc Use of semaphorin-4d binding molecules for treatment of atherosclerosis
NZ630892A (en) 2013-10-21 2016-03-31 Vaccinex Inc Use of semaphorin-4d binding molecules for treating neurodegenerative disorders
RU2759846C2 (ru) 2016-04-22 2021-11-18 Вэксинекс, Инк. Дисплей интегрального мембранного белка на внеклеточных оболочечных вирионах поксвируса
IL264343B2 (en) 2016-08-02 2024-05-01 Vaccinex Inc Improved methods for producing polynucleotide libraries in vaccinia virus/eukaryotic cells
JP7246320B2 (ja) 2017-05-05 2023-03-27 バクシネックス インコーポレーティッド ヒト抗セマフォリン４ｄ抗体
CN108499220B (zh) * 2018-04-25 2020-07-31 山东纯江环境科技有限公司 石墨烯/聚丙烯非织造布过滤网制备方法及其应用
JP2023530710A (ja) * 2020-06-19 2023-07-19 ザ ジェネラル ホスピタル コーポレイション 近赤外自己蛍光イメージングシステム及び方法
AU2021297152A1 (en) * 2020-06-25 2023-02-02 The Sydney Children's Hospitals Network Use of semaphorin-4D binding molecules for the treatment of Rett syndrome

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106474559A (zh) * 2016-11-30 2017-03-08 西南交通大学 一种在心血管植入材料表面构建Sema 4D/Heparin微环境的方法
CN106474559B (zh) * 2016-11-30 2019-07-12 西南交通大学 一种在心血管植入材料表面构建Sema 4D/Heparin微环境的方法
CN110325213A (zh) * 2017-02-22 2019-10-11 瓦西尼斯公司 神经退行性或神经炎性疾病中胶质细胞活化的早期检测
CN106983919A (zh) * 2017-03-06 2017-07-28 西南交通大学 一种Sema 4D‑VEGF涂层的构建方法及应用
CN106983919B (zh) * 2017-03-06 2019-07-12 西南交通大学 一种Sema 4D-VEGF涂层的构建方法及应用
WO2020083007A1 (zh) * 2018-10-22 2020-04-30 华中科技大学同济医学院附属协和医院 Sema4D/PlexinB1抑制剂在制备治疗及预防眼底血管疾病药物中的应用
CN116949097A (zh) * 2023-09-20 2023-10-27 江苏集萃药康生物科技股份有限公司 一种sema4d人源化小鼠模型的构建方法及其应用
CN116949097B (zh) * 2023-09-20 2023-12-12 江苏集萃药康生物科技股份有限公司 一种sema4d人源化小鼠模型的构建方法及其应用

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BR112016008010A2 (pt) 2017-09-26
EA201690728A1 (ru) 2016-08-31
KR20160062167A (ko) 2016-06-01
MX385575B (es) 2025-03-18
US9512224B2 (en) 2016-12-06
NZ630881A (en) 2016-03-31
MX2016004551A (es) 2016-07-22
EP3054976A1 (en) 2016-08-17
EA037551B1 (ru) 2021-04-13
EP3054976B1 (en) 2020-07-08
KR102366682B1 (ko) 2022-02-22
IL244976B (en) 2020-07-30
JP2016539089A (ja) 2016-12-15
US20150104462A1 (en) 2015-04-16
JP2019108359A (ja) 2019-07-04
ES2821814T3 (es) 2021-04-27
IL244976A0 (en) 2016-05-31
AU2014331683A1 (en) 2016-04-28
CA2926944C (en) 2023-08-08
JP6760840B2 (ja) 2020-09-23
WO2015054628A1 (en) 2015-04-16
CA2926944A1 (en) 2015-04-16
DK3054976T3 (da) 2020-09-28
ZA201602577B (en) 2020-11-25
SG11201602807PA (en) 2016-05-30
AU2014331683B2 (en) 2019-07-11
EP3054976A4 (en) 2017-05-17
PT3054976T (pt) 2020-08-05

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Application publication date: 20160810