CN105833134A - 一种治疗皮炎湿疹的中药组合物凝胶及其制备方法 - Google Patents
一种治疗皮炎湿疹的中药组合物凝胶及其制备方法 Download PDFInfo
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Abstract
本发明涉及一种治疗皮炎湿疹的中药组合物凝胶及其制备方法,中药组合物凝胶由中药提取物和凝胶成型剂组成,所述中药提取物由下列重量份的中药加工而成:白鲜皮4‑8份,苦参5‑10份,土茯苓6‑8份,地肤子6‑12份,连翘8‑12份,金银花5‑10份,荆芥6‑12份,黄柏6‑12份,蒲公英5‑10份,黄苓4‑10份,板蓝根6‑12份,香菜籽5‑8份,苦瓜片3‑9份,凝胶成型剂由去离子水、透明质酸和泊洛沙姆组成,药剂和凝胶成型剂分开储存,使用时二者以适宜的比例混合均匀。本发明有效成分不易氧化变质,保质期长,使用时与凝胶成型剂按比例混合均匀成凝胶,现混现用,保持极高的药物活性,涂覆于皮炎湿疹创面部位,使用非常方便,不易挥发变干,药物有效成分能长时间缓慢释放,治疗效果好。
Description
技术领域
本发明涉及一种药物凝胶及其制备方法,具体的说涉及一种治疗皮炎湿疹的中药组合物凝胶及其制备方法。
背景技术
皮炎、湿疹、汗疹等皮疹病症为常见的皮肤病,属于多发病和易发病。目前,治疗的主要方式为采用含有激素等化学药物成分的软膏、乳膏及消毒制剂进行外用涂抹,或服用抗阻胺药物(如氯雷他定等),其作用多以止痒为主,难以去除病因,且长期使用激素类成分,不仅会对身体产生诸多不利的不良反应,也易使病源微生物产生耐药性,进一步增大了消毒杀菌等治疗的难度,且上述的治疗效果都不是太理想。
发明内容
本发明的目的在于解决现有技术的不足,提供一种治疗皮炎湿疹的中药组合物凝胶。
本发明的另一个目的在于提供一种治疗皮炎湿疹的中药组合物凝胶的制备方法。
本发明解决其技术问题所采用的技术方案是:
一种治疗皮炎湿疹的中药组合物凝胶,所述中药组合物凝胶由中药提取物和凝胶成型剂组成,所述中药提取物由下列重量份的中药加工而成:白鲜皮 4-8份,苦参5-10份,土茯苓6-8份,地肤子6-12份,连翘8-12份,金银花5-10份,荆芥6-12份,黄柏6-12份,蒲公英5-10份,黄苓4-10份,板蓝根6-12份,香菜籽5-8份,苦瓜片3-9份,所述凝胶成型剂由去离子水、透明质酸和泊洛沙姆组成,药剂和凝胶成型剂分开储存,使用时二者以适宜的比例混合均匀。
白鲜皮:具有缓解风疹、湿疹和疥癣功能;
苦参:可以缓解湿疹,湿疮,皮肤瘙痒,疥癣;
土茯苓:解毒,除湿;
地肤子:清热利湿,祛风止痒;
连翘:清热,解毒,散结,消肿;
荆芥:祛风、解表和透疹;
香菜籽:含挥发油、苹果酸、钾盐、有机酸钙盐、脂肪、蛋白质、多种维生素以及含氮物质,可以改善皮疹的创面,有使创面干净,促进肉芽形成的作用;
苦瓜中含有能抑制恶性细胞生成和增强免疫细胞活性的蛋白酶,能够阻止恶性细胞的生长和扩散,具有明显的消炎作用。
本发明合理选取了白鲜皮 、苦参、土茯苓、地肤子、连翘、金银花、荆芥、黄柏、蒲公英、黄苓、板蓝根、香菜籽和苦瓜片,通过浸提、浓缩、冷冻干燥获得干粉,单独封存,不易结块,有效成分不易氧化变质,保质期长, 使用时与凝胶成型剂按比例混合均匀成凝胶,现混现用,保持极高的药物活性,涂覆于皮炎湿疹创面部位,使用非常方便,由于呈凝胶状,锁水性好,不易挥发变干,药物有效成分能长时间缓慢释放,治疗效果好。
优选的,所述中药提取物由下列重量份中药加工而成:白鲜皮 6份,苦参8份,土茯苓7份,地肤子10份,连翘10份,金银花8份,荆芥8份,黄柏8份,蒲公英6份,黄苓6份,板蓝根8份,香菜籽6份,苦瓜片5份。
优选的,所述凝胶成型剂的重量百分比组成如下:透明质酸0.5-0.8%,泊洛沙姆24-28%,余量为去离子水。
优选的,所述凝胶成型剂的重量百分比组成如下:透明质酸0.6%,泊洛沙姆25%,余量为去离子水。
优选的,所述中药提取物和凝胶成型剂的配比如下:每30-40g中药提取物配80-100ml凝胶成型剂,二者于常温下搅拌混合均匀。
一种所述治疗皮炎湿疹的中药组合物凝胶的制备方法:
(a)制备中药提取物:配方量的白鲜皮 、苦参、土茯苓、地肤子、连翘、金银花、荆芥、黄柏、蒲公英、黄苓、板蓝根、香菜籽和苦瓜片,加入150~200ml体积分数70-80%的乙醇水溶液,于90-110℃回流浸提2-3小时,浸提液经真空浓缩后冷冻干燥,获得中药提取物冷冻干粉,封装;
(b)制备凝胶成型剂:将配方量的透明质酸、泊洛沙姆和常温的去离子水混合均匀,然后微过滤去除杂质,封装;
中药提取物和凝胶成型剂分开储存,使用时二者以适宜的比例混合均匀,混合方式为中药提取物往凝胶成型剂中添加,边加边搅拌。
本发明的有益效果是:本发明合理选取了白鲜皮 、苦参、土茯苓、地肤子、连翘、金银花、荆芥、黄柏、蒲公英、黄苓、板蓝根、香菜籽和苦瓜片,通过浸提、浓缩、冷冻干燥获得干粉,单独封存,不易结块,有效成分不易氧化变质,保质期长, 使用时与凝胶成型剂按比例混合均匀成凝胶,现混现用,保持极高的药物活性,涂覆于皮炎湿疹创面部位,使用非常方便,由于呈凝胶状,锁水性好,不易挥发变干,药物有效成分能长时间缓慢释放,治疗效果好。
具体实施方式
下面通过具体实施例,对本发明的技术方案作进一步的具体说明。
实施例1:
一种治疗皮炎湿疹的中药组合物凝胶,所述中药组合物凝胶由中药提取物和凝胶成型剂组成,所述中药提取物由下列重量份的中药加工而成:白鲜皮 4份,苦参5份,土茯苓6份,地肤子6份,连翘8份,金银花5份,荆芥6份,黄柏6份,蒲公英5份,黄苓4份,板蓝根6份,香菜籽5份,苦瓜片3份, 所述凝胶成型剂的重量百分比组成如下:透明质酸0.5%,泊洛沙姆24%,余量为去离子水;
所述治疗皮炎湿疹的中药组合物凝胶的制备方法:
(a)制备中药提取物:配方量的白鲜皮 、苦参、土茯苓、地肤子、连翘、金银花、荆芥、黄柏、蒲公英、黄苓、板蓝根、香菜籽和苦瓜片,加入150ml体积分数80%的乙醇水溶液,于110℃回流浸提2小时,浸提液经真空浓缩后冷冻干燥,获得中药提取物冷冻干粉,封装;
(b)制备凝胶成型剂:将配方量的透明质酸、泊洛沙姆和常温的去离子水混合均匀,然后微过滤去除杂质,封装;
中药提取物和凝胶成型剂分开储存,使用时二者以适宜的比例混合均匀,混合方式为中药提取物往凝胶成型剂中添加,边加边搅拌,每30g中药提取物配80ml凝胶成型剂。
实施例2:
一种治疗皮炎湿疹的中药组合物凝胶,所述中药组合物凝胶由中药提取物和凝胶成型剂组成,所述中药提取物由下列重量份的中药加工而成:白鲜皮 8份,苦参10份,土茯苓8份,地肤子12份,连翘12份,金银花10份,荆芥12份,黄柏12份,蒲公英10份,黄苓10份,板蓝根12份,香菜籽8份,苦瓜片9份,所述凝胶成型剂的重量百分比组成如下:透明质酸0.8%,泊洛沙姆28%,余量为去离子水;
所述治疗皮炎湿疹的中药组合物凝胶的制备方法:
(a)制备中药提取物:配方量的白鲜皮 、苦参、土茯苓、地肤子、连翘、金银花、荆芥、黄柏、蒲公英、黄苓、板蓝根、香菜籽和苦瓜片,加入180ml体积分数70%的乙醇水溶液,于90℃回流浸提3小时,浸提液经真空浓缩后冷冻干燥,获得中药提取物冷冻干粉,封装;
(b)制备凝胶成型剂:将配方量的透明质酸、泊洛沙姆和常温的去离子水混合均匀,然后微过滤去除杂质,封装;
中药提取物和凝胶成型剂分开储存,使用时二者以适宜的比例混合均匀,混合方式为中药提取物往凝胶成型剂中添加,边加边搅拌,每40g中药提取物配100ml凝胶成型剂。
实施例3:
一种治疗皮炎湿疹的中药组合物凝胶,所述中药组合物凝胶由中药提取物和凝胶成型剂组成,所述中药提取物由下列重量份的中药加工而成:白鲜皮 6份,苦参8份,土茯苓7份,地肤子10份,连翘10份,金银花8份,荆芥8份,黄柏8份,蒲公英6份,黄苓6份,板蓝根8份,香菜籽6份,苦瓜片5份,所述凝胶成型剂的重量百分比组成如下:透明质酸0.6%,泊洛沙姆25%,余量为去离子水;
所述治疗皮炎湿疹的中药组合物凝胶的制备方法:
(a)制备中药提取物:配方量的白鲜皮 、苦参、土茯苓、地肤子、连翘、金银花、荆芥、黄柏、蒲公英、黄苓、板蓝根、香菜籽和苦瓜片,加入170ml体积分数75%的乙醇水溶液,于100℃回流浸提2.5小时,浸提液经真空浓缩后冷冻干燥,获得中药提取物冷冻干粉,封装;
(b)制备凝胶成型剂:将配方量的透明质酸、泊洛沙姆和常温的去离子水混合均匀,然后微过滤去除杂质,封装;
中药提取物和凝胶成型剂分开储存,使用时二者以适宜的比例混合均匀,混合方式为中药提取物往凝胶成型剂中添加,边加边搅拌,每35g中药提取物配90ml凝胶成型剂。
临床验证
1、病例 :门诊确诊的急性、亚急性皮炎湿疹患者
急性皮炎湿疹 :红斑,丘疹、丘疱疹,水疱,结痂
亚急性皮炎湿疹 :浸润性红斑,少量丘疹或丘疱疹,结痂
2、实验组 :120例,男性 60 例,女性 60 例,年龄 14 ~ 45岁,平均 34 岁,随机分成三组,
3、对照组 :40 例,男性20 例,女性20例,年龄 14~ 45岁,平均 34岁;
4、治疗方法 :实验组分别涂覆实施例1-3制备得到的中药组合物凝胶,每日3次,对照组 :涂覆皮炎平,每日三次。总疗程 2 周。
5、疗效判定 :痊愈 :皮损消退,症状消失 ;显效 :皮损消退至少 80%,症状明显改善 ;好转 :皮损消退 40-80%,症状有所改善 ;无效 :皮损消退≤ 40%,症状无改善。
6、结果 :实验组与对照组无显著差异,符合可比性。治疗结果如下:
痊愈 | 显效 | 好转 | 无效 | 总有效率 | |
实验组1 | 22 | 6 | 6 | 6 | 85% |
实验组2 | 20 | 10 | 6 | 4 | 90% |
实验组3 | 25 | 5 | 10 | 0 | 100% |
对照组 | 20 | 5 | 5 | 10 | 75% |
本发明合理选取了白鲜皮 、苦参、土茯苓、地肤子、连翘、金银花、荆芥、黄柏、蒲公英、黄苓、板蓝根、香菜籽和苦瓜片,通过浸提、浓缩、冷冻干燥获得干粉,单独封存,不易结块,有效成分不易氧化变质,保质期长, 使用时与凝胶成型剂按比例混合均匀成凝胶,现混现用,保持极高的药物活性,涂覆于皮炎湿疹创面部位,使用非常方便,由于呈凝胶状,锁水性好,不易挥发变干,药物有效成分能长时间缓慢释放,治疗效果好。
以上所述的实施例只是本发明的一种较佳的方案,并非对本发明作任何形式上的限制,在不超出权利要求所记载的技术方案的前提下还有其它的变体及改型。
Claims (6)
1.一种治疗皮炎湿疹的中药组合物凝胶,其特征在于:所述中药组合物凝胶由中药提取物和凝胶成型剂组成,所述中药提取物由下列重量份的中药加工而成:白鲜皮 4-8份,苦参5-10份,土茯苓6-8份,地肤子6-12份,连翘8-12份,金银花5-10份,荆芥6-12份,黄柏6-12份,蒲公英5-10份,黄苓4-10份,板蓝根6-12份,香菜籽5-8份,苦瓜片3-9份,所述凝胶成型剂由去离子水、透明质酸和泊洛沙姆组成,中药提取物和凝胶成型剂分开储存,使用时二者以适宜的比例混合均匀。
2.根据权利要求1所述的治疗皮炎湿疹的中药组合物凝胶,其特征在于:所述中药提取物由下列重量份中药加工而成:白鲜皮 6份,苦参8份,土茯苓7份,地肤子10份,连翘10份,金银花8份,荆芥8份,黄柏8份,蒲公英6份,黄苓6份,板蓝根8份,香菜籽6份,苦瓜片5份。
3.根据权利要求1所述的治疗皮炎湿疹的中药组合物凝胶,其特征在于:所述凝胶成型剂的重量百分比组成如下:透明质酸0.5-0.8%,泊洛沙姆24-28%,余量为去离子水。
4.根据权利要求3所述的治疗皮炎湿疹的中药组合物凝胶,其特征在于:所述凝胶成型剂的重量百分比组成如下:透明质酸0.6%,泊洛沙姆25%,余量为去离子水。
5.根据权利要求1所述的治疗皮炎湿疹的中药组合物凝胶,其特征在于:所述中药提取物和凝胶成型剂的配比如下:每30-40g中药提取物配80-100ml凝胶成型剂,二者于常温下搅拌混合均匀。
6.一种权利要求1-5任意一项所述的治疗皮炎湿疹的中药组合物凝胶的制备方法,其特征在于:
(a)制备中药提取物:配方量的白鲜皮 、苦参、土茯苓、地肤子、连翘、金银花、荆芥、黄柏、蒲公英、黄苓、板蓝根、香菜籽和苦瓜片,加入150~200ml体积分数70-80%的乙醇水溶液,于90-110℃回流浸提2-3小时,浸提液经真空浓缩后冷冻干燥,获得中药提取物冷冻干粉,封装;
(b)制备凝胶成型剂:将配方量的透明质酸、泊洛沙姆和常温的去离子水混合均匀,然后微过滤去除杂质,封装;
中药提取物和凝胶成型剂分开储存,使用时二者以适宜的比例混合均匀,混合方式为中药提取物往凝胶成型剂中添加,边加边搅拌。
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106491856A (zh) * | 2016-10-21 | 2017-03-15 | 济南豪瑞生物技术有限公司 | 透明质酸抑菌凝胶 |
CN107149568A (zh) * | 2017-03-27 | 2017-09-12 | 广西厚德大健康产业股份有限公司 | 一种止痒凝胶的制备方法 |
CN117357467A (zh) * | 2023-10-26 | 2024-01-09 | 广东茂名健康职业学院 | 一种缓解皮肤炎症的中药凝胶及其制备方法 |
-
2016
- 2016-05-19 CN CN201610334047.0A patent/CN105833134A/zh not_active Withdrawn
Non-Patent Citations (3)
Title |
---|
宋业强: ""赵纯修应用白鲜皮饮治疗皮肤病经验"", 《山东中医杂志》 * |
宋业强: "赵纯修辨证治疗湿疹的经验", 《四川中医》 * |
林致远: "《大国医大全集》", 30 June 2012 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106491856A (zh) * | 2016-10-21 | 2017-03-15 | 济南豪瑞生物技术有限公司 | 透明质酸抑菌凝胶 |
CN107149568A (zh) * | 2017-03-27 | 2017-09-12 | 广西厚德大健康产业股份有限公司 | 一种止痒凝胶的制备方法 |
CN117357467A (zh) * | 2023-10-26 | 2024-01-09 | 广东茂名健康职业学院 | 一种缓解皮肤炎症的中药凝胶及其制备方法 |
CN117357467B (zh) * | 2023-10-26 | 2024-04-26 | 广东茂名健康职业学院 | 一种缓解皮肤炎症的中药凝胶及其制备方法 |
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