WO2016180119A1 - 一种外用制剂及其在制备治疗腰间盘突出药物中的应用 - Google Patents

一种外用制剂及其在制备治疗腰间盘突出药物中的应用 Download PDF

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WO2016180119A1
WO2016180119A1 PCT/CN2016/078739 CN2016078739W WO2016180119A1 WO 2016180119 A1 WO2016180119 A1 WO 2016180119A1 CN 2016078739 W CN2016078739 W CN 2016078739W WO 2016180119 A1 WO2016180119 A1 WO 2016180119A1
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acetic acid
preparation
pepper
pharmaceutical preparation
lumbar disc
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PCT/CN2016/078739
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English (en)
French (fr)
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寿根其
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寿根其
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Definitions

  • the invention relates to a pharmaceutical preparation for external use, a preparation method thereof and application thereof in preparing a medicine for treating lumbar disc herniation.
  • Lumbar disc herniation is a common disease. It is difficult to treat. The risk of surgical treatment is very high. The recurrence rate is 30%-50%. Improper surgery can cause generalized paralysis. The medicine for treating lumbar disc herniation is relatively rare.
  • Chinese patent application CN02109766 introduces an oral Chinese medicine for treating lumbar disc herniation and bone hyperplasia, which is prepared by using traditional Chinese medicines such as hematoxylin, salvia, and achyranthes.
  • Chinese patent application CN03100479 introduced a "Bai Kang paste" plaster, using bear bile, Cordyceps sinensis, saffron, earth dragon, water horn, blood, angelica, turtle shell, seesaw, Daqingye, Codonopsis, ginseng, Sanqi, Made from red ginseng, earthworm, flowering snake, whole insect, and spatholobus.
  • the effects of these drugs are not very prominent, and rarely can obviously work.
  • the present invention is directed to an external pharmaceutical preparation effective for treating lumbar disc herniation and a preparation method thereof, and another object of the present invention relates to the use of the pharmaceutical preparation for the preparation of a medicament for treating lumbar disc herniation.
  • a pharmaceutical preparation for external use which is prepared by adding the following ingredients per 1000 g of the fermentation liquid (Liquid A):
  • Ginger oil 0.10-0.15g
  • the fermentation broth is prepared as follows: the pepper is mixed with the aqueous solution of acetic acid, and then fermented at a temperature of 15 ° C to 20 ° C for 7-9 days, and then the filtrate is filtered to obtain a fermentation liquid, wherein the acetic acid aqueous solution has an acetic acid weight content of 7 %-9%, the pepper is added in an amount of 1.5-2.5 g/10 g of aqueous acetic acid, preferably 2-2.3 g/10 g of aqueous acetic acid, based on the weight of dry chili.
  • the peppers described in the external pharmaceutical preparation of the present invention are recommended as capsicum pieces, more preferably dried capsicum pieces.
  • the dried chili chips according to the present invention may be dried to the extent that the dried peppers are easily crushed by both hands.
  • the present invention preferably is a pharmaceutical preparation for external use, which is prepared by adding the following ingredients per 1000 g of the fermentation broth:
  • Ginger oil 0.12-0.15g
  • the fermentation broth is prepared as follows: the pepper is mixed with the aqueous solution of acetic acid, and then fermented at a temperature of 15 ° C to 20 ° C for 7-9 days, and then the filtrate is filtered to obtain a fermentation liquid, and the aqueous solution of acetic acid is used.
  • the weight content of acetic acid is 7% to 9%, and the pepper is added in an amount of 2-2.3 g/10 g of aqueous acetic acid based on the weight of dry pepper.
  • the fermentation broth is most preferably prepared by mixing the pepper with an aqueous solution of acetic acid, fermenting at 18 ° C to 20 ° C for 7-8 days, and then filtering the filtrate to obtain a fermentation broth. 7% to 9%, the pepper is added in an amount of 2-2.15 g/10 g of aqueous acetic acid based on the weight of the dried chili.
  • the present invention also provides a method for preparing the external pharmaceutical preparation, which is carried out as follows:
  • liquid A the crushed pepper is mixed with the aqueous solution of acetic acid, and then fermented at a temperature of 15 ° C to 20 ° C for 7-9 days, and then the filtrate is filtered to obtain a fermentation liquid, that is, liquid A, and the acetic acid weight content in the aqueous acetic acid solution. 7% to 9%, the pepper is added in an amount of 2-2.3 g/10 g of aqueous acetic acid based on the weight of the dried chili.
  • the external pharmaceutical preparation is a liquid preparation, and the color of the liquid is usually changed from rose to pink as the preparation starts to the end. When the liquid turns pink, the preparation is prepared and can be used at any time. The external preparation is placed for a period of time. There is a small amount of precipitation afterwards, but it does not affect the effect of use.
  • the invention also relates to the use of the external pharmaceutical preparation for preparing a medicament for treating lumbar disc herniation, and the specific prepared external preparation is generally used for directly coating the affected part of the lumbar disc. It is recommended to apply 1-3 times a day, usually about 7 days to eliminate pain, longer course, 1-3 months can also be cured, treatment time is short, the effect is ideal.
  • the external pharmaceutical preparations of the present invention are compared with the prior art, and the beneficial effects of the present invention are mainly embodied by: providing a brand-new external pharmaceutical preparation agent which can be used for the treatment of lumbar disc herniation, It is easy to use, short in treatment and safe to use, which brings good news to patients with lumbar disc herniation.
  • liquid A the crushed pepper is mixed with the aqueous solution of acetic acid, and then fermented at a temperature of 15 ° C to 20 ° C for 7-9 days, and then the filtrate is filtered to obtain a fermentation liquid, that is, liquid A, and the acetic acid weight content in the aqueous acetic acid solution. 7% to 9%, the pepper is added in an amount of 1.6-2.5 g/10 g of aqueous acetic acid based on the weight of the dried chili.
  • the color of the liquid changes from rose red to pink, and the preparation is prepared and ready for use.
  • the preparation has a small amount of precipitation after being left for a while, but does not affect the use effect.
  • component A 4150 g of an aqueous solution of 8% acetic acid (i.e., an aqueous solution of acetic acid having an acetic acid content of 8% by weight, the same applies) was placed in a glass bottle, and 850 g of dried ground pepper was added to make it uniform. After mixing, the mixture was naturally fermented at an ambient temperature of 20 ° C. After 7 days, the fermentation was completed and filtered to obtain 4050 g of liquid A.
  • 8% acetic acid i.e., an aqueous solution of acetic acid having an acetic acid content of 8% by weight, the same applies
  • component B 7.3 ml of clove basil oil, 4.8 ml of methyl salicylate, 0.14 g of ginger eucalyptus oil, 0.277 g of cinnamon oil, 0.277 g of cinnamaldehyde, 0.009 g of citral, and 0.03 g of borneol.
  • Formulation preparation Take the liquid A1000g into the beaker and gradually add various kinds in the B formula. The ingredients are stirred while being added until the ingredients in the B formulation are all dissolved to obtain the target preparation.
  • component A 4100 g of a 9% aqueous solution of acetic acid was placed in a glass bottle, and 880 g of dried crushed pepper was added thereto, and the mixture was uniformly mixed, and then naturally fermented, and the ambient temperature was 18 ° C. After 8 days, the fermentation was completed and filtered. 4000 g of liquid A were obtained.
  • component B 7.5 ml of clove basil oil, 5 ml of methyl salicylate, 0.15 g of ginger eucalyptus oil, 0.28 g of cinnamon oil, 0.28 g of cinnamaldehyde, 0.01 g of citral, and 0.04 g of borneol.
  • Formulation preparation 1000 g of liquid A is placed in a beaker, and each component in the B formula is gradually added, and stirred while being added, until all the components in the B formulation are dissolved to obtain the target preparation.
  • component A 4200g of 7% acetic acid aqueous solution was placed in a glass bottle, and 850g of dried ground pepper was added to make it evenly mixed, so that it was naturally fermented, the ambient temperature was 20 ° C, and after 7 days, the fermentation was completed and filtered. 4100 g of liquid A were obtained.
  • component B 7.2 ml of clove basil oil, 4.5 ml of methyl salicylate, 0.12 g of ginger eucalyptus oil, 0.25 g of cinnamon oil, 0.25 g of cinnamaldehyde, 0.006 g of citral, and 0.02 g of borneol.
  • Formulation preparation 1000 g of liquid A is placed in a beaker, and each component in the B formula is gradually added, and stirred while being added, until all the components in the B formulation are dissolved to obtain the target preparation.
  • component A 4000 g of an aqueous solution of 8% acetic acid (i.e., an aqueous solution of acetic acid having an acetic acid content of 8% by weight) was placed in a glass bottle, and 920 g of dried ground pepper was added thereto, and the mixture was uniformly mixed. It is naturally fermented, the ambient temperature is 15 ° C, and after 9 days, the fermentation is completed and filtered. To 3900g liquid A.
  • 8% acetic acid i.e., an aqueous solution of acetic acid having an acetic acid content of 8% by weight
  • component B 31.2 ml of clove basil oil, 15.6 ml of methyl salicylate, 0.39 g of ginger eucalyptus oil, 1.17 g of cinnamon oil, 1.17 g of cinnamaldehyde, 0.0195 g of citral, 0.117 g of borneol; 8 ml of clove basil oil, 4 ml of methyl salicylate, 0.1 g of ginger eucalyptus oil, 0.3 g of cinnamon oil, 0.3 g of cinnamaldehyde, 0.005 g of citral, and 0.03 g of borneol were added to 1000 g of liquid A1.
  • Formulation preparation Take liquid A3900g into a beaker, gradually add various ingredients in the B formula, and stir while adding, until the various components in the B formula are all dissolved to obtain the target preparation.
  • component A 3800 g of an aqueous solution of acetic acid having a concentration of 9% (i.e., an aqueous solution of acetic acid having a content of 9% by weight of acetic acid) was placed in a glass bottle, and 950 g of dried ground pepper was added thereto, and the mixture was uniformly mixed. It was naturally fermented at an ambient temperature of 15 ° C. After 8 days, the fermentation was completed and filtered to obtain 3700 g of liquid A.
  • aqueous solution of acetic acid having a concentration of 9% i.e., an aqueous solution of acetic acid having a content of 9% by weight of acetic acid
  • component B 29.6 ml of clove basil oil, 18.5 ml of methyl salicylate, 0.481 g of ginger eucalyptus oil, 0.74 g of cinnamon oil, 0.74 g of cinnamaldehyde, 0.0296 g of citral, 0.074 g of borneol; 8 ml of clove basil oil, 5 ml of methyl salicylate, 0.13 g of ginger eucalyptus oil, 0.2 g of cinnamon oil, 0.2 g of cinnamaldehyde, 0.008 g of citral, and 0.02 g of borneol were added to 1000 g of liquid A1.
  • Formulation preparation Take liquid A3700g into a beaker, gradually add various ingredients in the B formula, and stir while adding, until all the components in the B formula are dissolved to obtain the target preparation.
  • component A 4800 g of an aqueous solution of acetic acid having a concentration of 7% (i.e., an aqueous solution of acetic acid having a content of 7% by weight of acetic acid) was placed in a glass bottle, and 768 g of dried ground pepper was added thereto, and the mixture was uniformly mixed. It is naturally fermented, the ambient temperature is 19 ° C, and after 9 days, the fermentation is completed and filtered. Up to 4700g of liquid A.
  • component B clove basil oil 32.9 ml, methyl salicylate 18.8 ml, ginger eucalyptus oil 0.47 g, cinnamon oil 0.94 g, cinnamaldehyde aldehyde 0.94 g, citral 0.0235 g, borneol 0.094 g; 7 ml of clove basil oil, 4 ml of methyl salicylate, 0.1 g of ginger eucalyptus oil, 0.2 g of cinnamon oil, 0.2 g of cinnamaldehyde, 0.005 g of citral, and 0.02 g of borneol were added to 1000 g of liquid A1.
  • Formulation preparation Take liquid A4700g into a beaker, gradually add various ingredients in the B formula, and stir while adding, until all the components in the B formula are dissolved to obtain the target preparation.
  • the concentrations of the preparations prepared in the above six examples were slightly different, but the therapeutic effects were not significantly different.
  • the preparation is characterized in that: when the preparation is used for treating patients with lumbar disc herniation, only a few preparations can be applied to the lumbar disc herniation, and the dosage is less than 0.5 ml each time. 1-3 times a day, 7 days to basically eliminate the pain, the cortical bones are self-repairing, usually once a day. If the onset time is more than 3 months, there is even a history of 3-30 years, and there is a hard substance condensed by phosphorus, calcium, magnesium, etc.
  • aqueous acetic acid solution can be prepared by mixing glacial acetic acid and water in a desired ratio.
  • Aqueous acetic acid solution, pepper pepper accelerates the penetration of acetic acid and improves the environment around the lesion.
  • Clove basil oil local analgesia, antiseptic.
  • Methyl salicylate has a local stimulating effect, can promote blood circulation, reduce swelling, anti-inflammatory and Analgesic effect.
  • Cinnamon oil Dispelling cold and relieving pain, promoting blood circulation and exhaling, helping to treat rheumatism and itchy skin.
  • Cinnamaldehyde It has the functions of sterilization, disinfection, antisepsis, analgesia, blood stasis and blood circulation
  • Citral antibacterial and antiseptic.
  • Borneol good to disperse qi, loose blood, scattered fire, stagnation, stagnation, evil spirits, can remove heat through the bones, for wind toxic bones, toothache, hemorrhoids, red eyes and swelling, sore throat, no accumulation after collapse efficacy.
  • Example 1 Gu ⁇ ⁇ , female, 53 years old, went to the hospital in August 1985 due to physical discomfort, confirmed by the doctor after the examination of lumbar disc herniation and cervical spondylosis. Until June 2014, the symptoms were not completely cured, and the symptoms of numbness appeared in both hands. The preparation of Example 1 was started on the morning of June 20, 2014, and the affected area was applied twice a day. After 7 days, the pain basically disappeared, and after 20 days, the symptoms disappeared completely, and after one week of application, the application was stopped. It has been nearly a year so far and has not relapsed. Note: The reagents used are 2 times/day for the first week and 1-2 times/day after.
  • Example 2 Xu ⁇ ⁇ , male, 58 years old, went to the hospital (Jiaxing Armed Police Hospital) due to physical discomfort in August 2008. After examination, he was confirmed as lumbar disc herniation and cervical spondylosis, but this condition has not been completely treated.
  • the preparation of Example 1 was started until the afternoon of April 18, 2014, and the affected area was applied three times a day. After 7 days, the pain basically disappeared, and after 10 days, the pain completely disappeared, and after one week of application, the application was stopped. There has been no recurrence for one year so far.
  • Example 3 Xu ⁇ ⁇ , female, 49 years old, suffering from lumbar disc herniation for 2 months, using the preparation of Example 1 to apply the affected area once a day, after 7 days of application, the symptoms disappeared completely, and after 1 week of application, the application was stopped. It has been 8 months so far and no recurrence has been seen.
  • Example 4 Zhu ⁇ ⁇ , female, 43 years old, suffering from lumbar disc herniation for 6 months, using the preparation of Example 1 every day Apply the affected area once, and the symptoms disappear completely after 7 days of application. After 1 week of application, the application is stopped. It has been 7 months so far and no recurrence has been seen.
  • Example 1 Gu ⁇ ⁇ , female, 53 years old, suffering from lumbar disc herniation for 2 years, using the preparation of Example 1 to apply the affected area once a day, after 20 days of application, the symptoms disappeared completely, and after 1 week of application, the application was stopped. It has been a year since then and no recurrence has been seen.
  • Example 6 Xu ⁇ ⁇ , female, 63 years old, suffering from lumbar disc herniation for 4 years, using the preparation of Example 1 to apply the affected area once a day, after 20 days of application, the symptoms disappeared completely, and after 2 weeks of application, the application was stopped. It has been a year since then and no recurrence has been seen.
  • Example 1 9, Xu ⁇ ⁇ , male, 58 years old, suffering from lumbar disc herniation for 3 years, using the preparation of Example 1 to apply the affected area once a day, after 10 days of application, the symptoms disappeared completely, and after 1 week of application, the application was stopped. It has been a year since then and no recurrence has been seen.
  • Example 2 Male, 52 years old, suffering from lumbar disc herniation for 8 years (has been opened in the hospital six months before the year). The preparation of Example 2 was applied to the affected area 3 times a day, and the symptoms were completely after 7 days of application. Disappeared and stopped after 10 days of application. It has been a year since then and no recurrence has been seen.
  • Example 2 Zhang ⁇ ⁇ , female, 52 years old, suffering from lumbar disc herniation for one year and six months, using the preparation of Example 2 to apply the affected area once a day, after 10 days of application, the symptoms disappeared completely, and after 1 week of application, the application was stopped. It has been a year since then and no recurrence has been seen.
  • Example 3 to apply the affected area once a day, after 7 days of application, the symptoms disappeared completely, and after 1 week of application, the application was stopped. It has been a year since then and no recurrence has been seen.
  • Example 5 Wang ⁇ ⁇ , male, 65 years old, Nantong, Jiangsu province, suffering from acute lumbar disc herniation in June 2015 and very sore, while the feet are also sore, using the preparation of Example 5 to apply the affected area twice a day, 3 days later No recurrence.
  • Example 4 Lao ⁇ ⁇ , female, 45 years old, Jiaxing, Zhejiang, suffering from lumbar disc herniation had been treated in the hospital for 7 years. After recurrence, the pain was unbearable. She had no obvious effect everywhere. In May 2015, the preparation of Example 4 was applied to the affected area once a day, and it was completely recovered by September 2015, and no recurrence has been achieved so far.
  • Example 5 Wang ⁇ ⁇ , male, 32 years old, Jiaxing, Zhejiang, suffering from lumbar disc herniation, September 2015 The preparation of Example 5 was applied once a day to the affected area, and recovered after 1 month, and has not relapsed so far.
  • Example 6 32, ⁇ ⁇ ⁇ , female, 38 years old, Jiaxing, Zhejiang, suffering from lumbar disc herniation.
  • the preparation of Example 6 was applied to the affected area once a day, and returned to normal after 5 months. No recurrence has been seen so far.
  • Example 6 Wang ⁇ ⁇ , male, 28 years old, Jiaxing, Zhejiang, suffered from lumbar disc herniation. She was treated in the hospital and relapsed after two and a half years. In October 2014, the preparation of Example 6 was applied to the affected area once a day, and returned to normal after 2 days. No recurrence has been seen so far.
  • Example 6 was applied to the affected area once a day, and returned to normal after 3 months. No recurrence has been seen so far.
  • Example 5 Li ⁇ ⁇ , female, 35 years old, Guizhou, suffering from lumbar disc herniation, the body is sore and uncomfortable, in August 2015, the application of Example 5 was applied to the affected area once a day, and returned to normal after 2 days. No recurrence has been seen so far.
  • Example 5 Li ⁇ ⁇ , female, 34 years old, Guizhou, suffering from lumbar disc herniation, the body is very sore and can not work properly.
  • the application of Example 5 was applied to the affected area once a day, and returned to normal after 1 day. No recurrence has been seen so far. .
  • Example 4 was applied to the affected area once a day. After 3 months, it completely returned to normal. relapse.
  • Example 6 Wang ⁇ ⁇ , male, 30 years old, Shandong Heze, suffering from cervical spondylosis for 5 months and hands with hemp, use the preparation of Example 6 to apply the affected area once a day, return to health after 2 months, no recurrence has been seen so far.
  • Example 4 was applied to the affected area once a day. After 1 month, it was completely restored to health. relapse.
  • Example 6 Lin ⁇ ⁇ , female, 80 years old, Ninghai, Zhejiang, suffering from lumbar disc herniation for many years, diagnosed by the hospital: the third section of the lumbar vertebrae compression nerve caused the right foot can not stand upright free walking, August 2014 The preparation of Example 6 was applied once a day to the affected area, and after one month, the patient was able to get out of bed and continue to recover after 15 days of use. No recurrence has been seen so far.
  • Example 6 71, Mo ⁇ , female, 82 years old, Nantong, Jiangsu, lumbar disc herniation. In September 2014, the preparation of Example 6 was applied to the affected area once a day. It was completely recovered in 1 month and no recurrence has been seen so far.

Abstract

公开了一种治疗腰间盘突出的外用药物制剂及其制备方法和应用。该药物制剂是在每1000g发酵液中加入如下成分制得：丁香罗勒油7－8ml，水杨酸甲酯4－5ml，姜樟油0.10－0.15g，肉桂油0.2－0.3g，桂皮醛0.2－0.3g，柠檬醛0.005－0.01g，冰片0.02－0.04g。辣椒与乙酸重量含量为7％－9％的醋酸水溶液混匀后于15℃－20℃温度条件下发酵7－9天，过滤得发酵液。辣椒以干辣椒重量计加入量为1.6－2.5g/10g醋酸水溶液。

Description

一种外用制剂及其在制备治疗腰间盘突出药物中的应用 (一)技术领域
本发明涉及一种外用药物制剂、其制备方法及其在制备治疗腰间盘突出药物中的应用。
(二)背景技术
腰间盘突出是一种常见病，治疗比较困难，手术治疗风险性很大，复发率在30％－50％，手术不当会造成全身瘫痪，治疗腰间盘突出的药也比较少见。
中国专利申请CN02109766介绍了一种治疗腰间盘凸出、骨质增生的口服中药，采用苏木、丹参、牛膝等中药煎制而成。中国专利申请CN03100479介绍了一种“百康贴”膏药，用熊胆、冬虫夏草、藏红花、地龙、水中角、血力、当归、龟板、鳖板、大青叶、党参、人参、三七、红参、土虫、百花蛇、全虫、鸡血藤等制成。但这些药物的效果都个不太突出，很少能明显起效。
(三)发明内容
本发明旨在提供一种对治疗腰间盘突出有效的外用药物制剂以及制备方法，本发明的另一发明目的涉及这种药物制剂在制备治疗腰间盘突出药物中的应用。
为实现本发明的目的，本发明技术方案如下：
一种外用药物制剂，所述的药物制剂是在每1000g发酵液(液体A)中加入如下成分制得：
丁香罗勒油7－8ml，
水杨酸甲酯4－5ml，
姜樟油0.10－0.15g，
肉桂油0.2－0.3g，
桂皮醛0.2－0.3g，
柠檬醛0.005－0.01g，
冰片0.02－0.04g
所述的发酵液按如下方法制得：辣椒与醋酸水溶液混匀后于15℃－20℃温度条件下发酵7－9天后过滤取滤液得发酵液，所述的醋酸水溶液中乙酸重量含量为7％－9％，所述的辣椒以干辣椒重量计加入量为1.5－2.5g/10g醋酸水溶液，优选2－2.3g/10g醋酸水溶液。
本发明所述的外用药物制剂中所述的辣椒推荐为辣椒碎片，更优选为干的辣椒碎片。本发明所述的干的辣椒碎片指干辣椒用双手容易捏碎的干燥程度即可。
进一步，本发明优选所述的外用药物制剂，所述的药物制剂是在每1000g发酵液中加入如下成分制得：
丁香罗勒油7.2－7.5ml，
水杨酸甲酯4－5ml，
姜樟油0.12－0.15g，
肉桂油0.25－0.28g，
桂皮醛0.25－0.28g，
柠檬醛0.006－0.01g，
冰片0.02－0.04g
所述的发酵液按如下方法制得：辣椒与醋酸水溶液混匀后于15℃－20℃温度条件下发酵7－9天后过滤取滤液得发酵液，所述的醋酸水溶液中 乙酸重量含量为7％－9％，所述的辣椒以干辣椒重量计加入量为2－2.3g/10g醋酸水溶液。
所述的发酵液最优选按如下方法制得：辣椒与醋酸水溶液混匀后于18℃－20℃温度条件下发酵7－8天后过滤取滤液得发酵液，所述的醋酸水溶液中乙酸重量含量为7％－9％，所述的辣椒以干辣椒重量计加入量为2－2.15g/10g醋酸水溶液。
另外，本发明还提供该外用药物制剂的制备方法，所述的方法按如下步骤进行：
(1)液体A的配制：将碎辣椒与醋酸水溶液混匀后于15℃－20℃温度条件下发酵7－9天后过滤取滤液得发酵液即液体A，所述的醋酸水溶液中乙酸重量含量为7％－9％，所述的辣椒以干辣椒重量计加入量为2－2.3g/10g醋酸水溶液。
(2)按每1000g发酵液加入如下剂量的成份：丁香罗勒油7－8ml，水杨酸甲酯4－5ml，姜樟油0.10－0.15g，肉桂油0.2－0.3g，桂皮醛0.2－0.3g，柠檬醛0.005－0.01g，冰片0.02－0.04g；搅拌充分全部溶化即得外用药物制剂。
该外用药物制剂为水剂，药液的色泽随着配制开始到最后通常从玫红变成粉红，当药液变成粉红时制剂即告制成，可随时使用，该外用药物制剂放置一段时间后有少量沉淀，但不影响使用效果。
本发明还涉及的该外用药物制剂在制备治疗腰间盘突出药物中的应用，具体的制备得的外用药物制剂通常可用于直接涂沫于腰间盘突出的患处。推荐每天涂沫1－3次，通常约7天就能消除疼痛，病程较长的，1－3个月也能治愈，治疗时间短，效果理想。
本发明涉及的外用药物制剂与现有技术相比，本发明的有益效果主要体现在：提供了一种全新的可用于腰间盘突出治疗的外用药物制剂剂， 使用方便，疗程短，使用安全，为腰间盘突出患者带来了福音。
(四)具体实施方式
下面结合具体实施例对本发明进行进一步描述，但本发明的保护范围并不仅限于此：
本发明实施例治疗腰间盘突出的制剂的制备方法包括如下步骤：
(1)液体A的配制：将碎辣椒与醋酸水溶液混匀后于15℃－20℃温度条件下发酵7－9天后过滤取滤液得发酵液即液体A，所述的醋酸水溶液中乙酸重量含量为7％－9％，所述的辣椒以干辣椒重量计加入量为1.6－2.5g/10g醋酸水溶液。
(2)按每1000g发酵液(液体A)加入如下剂量的成份：丁香罗勒油7－8ml，水杨酸甲酯4－5ml，姜樟油0.10－0.15g，肉桂油0.2－0.3g，桂皮醛0.2－0.3g，柠檬醛0.005－0.01g，冰片0.02－0.04g；搅拌充分全部溶化即得目标制剂。
液体的色泽从玫红变成粉红，本制剂即告制成，可随时使用。制剂放置一段时间后有少量沉淀，但不影响使用效果。
实施例1
(1)成分A的配制：在玻璃瓶内放入浓度8％的醋酸水溶液4150g(即乙酸的含量为8％重量百分比的醋酸的水溶液，以下皆同)，加入干碎辣椒850g，使其均匀混合后，令其自然发酵，环境温度20℃，7天后发酵完毕，过滤，得到4050g液体A。
(2)成分B的配方：丁香罗勒油7.3ml，水杨酸甲酯4.8ml，姜樟油0.14g，肉桂油0.277g，桂皮醛0.277g，柠檬醛0.009g，冰片0.03g。
(3)配制制剂：取液体A1000g放入烧杯中，逐步加入B配方中的各种 成分，边加入边搅拌，直到B配方中的各种成分全部溶化即得目标制剂。
实施例2
(1)成分A的配制：在玻璃瓶内放入浓度9％的醋酸水溶液4100g，加入干碎辣椒880g，使其均匀混合后，自然发酵，环境温度在18℃，8天后发酵完毕，过滤，得到4000g液体A。
(2)成分B的配方：丁香罗勒油7.5ml，水杨酸甲酯5ml，姜樟油0.15g，肉桂油0.28g，桂皮醛0.28g，柠檬醛0.01g，冰片0.04g。
(3)配制制剂：取液体A 1000g放入烧杯中，逐步加入B配方中的每种成分，边加入边搅拌，直到B配方中的各种成分全部溶化即得目标制剂。
实施例3
(1)成分A的配制：在玻璃瓶内放入浓度7％醋酸水溶液4200g，加入干碎辣椒850g，使其均匀混合，令其自然发酵，环境温度在20℃，7天后发酵完毕，过滤，得到4100g液体A。
(2)成分B的配方：丁香罗勒油7.2ml，水杨酸甲酯4.5ml，姜樟油0.12g，肉桂油0.25g，桂皮醛0.25g，柠檬醛0.006g，冰片0.02g。
(3)配制制剂：取液体A 1000g放入烧杯中，逐步加入B配方中的每种成分，边加入边搅拌，直到B配方中的各种成分全部溶化即得目标制剂。
实施例4
(1)成分A的配制：在玻璃瓶内放入浓度8％的醋酸水溶液4000g(即乙酸的含量为8％重量百分比的醋酸的水溶液)，加入干碎辣椒920g，使其均匀混合后，令其自然发酵，环境温度15℃，9天后发酵完毕，过滤，得 到3900g液体A。
(2)成分B的配方：丁香罗勒油31.2ml，水杨酸甲酯15.6ml，姜樟油0.39g，肉桂油1.17g，桂皮醛1.17g，柠檬醛0.0195g，冰片0.117g；(相当于每1000g液体A1中加丁香罗勒油8ml，水杨酸甲酯4ml，姜樟油0.1g，肉桂油0.3g，桂皮醛0.3g，柠檬醛0.005g，冰片0.03g。
(3)配制制剂：取液体A3900g放入烧杯中，逐步加入B配方中的各种成分，边加入边搅拌，直到B配方中的各种成分全部溶化即得目标制剂。
实施例5
(1)成分A的配制：在玻璃瓶内放入浓度9％的醋酸水溶液3800g(即乙酸的含量为9％重量百分比的醋酸的水溶液)，加入干碎辣椒950g，使其均匀混合后，令其自然发酵，环境温度15℃，8天后发酵完毕，过滤，得到3700g液体A。
(2)成分B的配方：丁香罗勒油29.6ml，水杨酸甲酯18.5ml，姜樟油0.481g，肉桂油0.74g，桂皮醛0.74g，柠檬醛0.0296g，冰片0.074g；(相当于每1000g液体A1中加丁香罗勒油8ml，水杨酸甲酯5ml，姜樟油0.13g，肉桂油0.2g，桂皮醛0.2g，柠檬醛0.008g，冰片0.02g。
(3)配制制剂：取液体A3700g放入烧杯中，逐步加入B配方中的各种成分，边加入边搅拌，直到B配方中的各种成分全部溶化即得目标制剂。
实施例6
(1)成分A的配制：在玻璃瓶内放入浓度7％的醋酸水溶液4800g(即乙酸的含量为7％重量百分比的醋酸的水溶液)，加入干碎辣椒768g，使其均匀混合后，令其自然发酵，环境温度19℃，9天后发酵完毕，过滤，得 到4700g液体A。
(2)成分B的配方：丁香罗勒油32.9ml，水杨酸甲酯18.8ml，姜樟油0.47g，肉桂油0.94g，桂皮醛0.94g，柠檬醛0.0235g，冰片0.094g；(相当于每1000g液体A1中加丁香罗勒油7ml，水杨酸甲酯4ml，姜樟油0.1g，肉桂油0.2g，桂皮醛0.2g，柠檬醛0.005g，冰片0.02g。
(3)配制制剂：取液体A4700g放入烧杯中，逐步加入B配方中的各种成分，边加入边搅拌，直到B配方中的各种成分全部溶化即得目标制剂。
上述6个实施例制得的制剂浓度稍有差别，但治疗效果没明显区别。本制剂的特点是：用本制剂对腰间盘突出的病人治疗时，只要在腰间盘突出处涂上几点制剂即可，每次用量不到0.5毫升。每天1－3次，7天就基本消除疼痛，被腐蚀的骨皮自行修合，通常一天一次即可。如果发病时间在3个月以上，甚至已有3－30年病史，而且在腰间盘骨外已有磷、钙、镁等所凝结的硬物，经本制剂涂1－3个月后上述症状也能消失，并且，此药水涂了7天后，可以视病情的缓解程度适当减少涂的次数，如每天1－2次，甚至可减少到隔一天涂一次。症状全部消失后，再涂一、二周即可。试用了本药水的患者，到目前为止康复后最长的已有一年二个月，均未见复发。
本制剂所用的原料皆可从市场上买到，醋酸水溶液可用冰醋酸和水按所需比例混合而成。
本制剂中各成分的作用：
醋酸水溶液、辣椒：辣椒加速醋酸的渗透，改善病变周围的环境。
丁香罗勒油：局部镇痛，防腐药。
水杨酸甲酯：具有局部刺激作用，可促进血液循环，起消肿、消炎和 镇痛作用。
肉桂油：散寒止痛，活血通经，驱风，有助于治疗风湿及皮肤瘙痒。
桂皮醛：具有杀菌、消毒、防腐、镇痛、散淤血和促进血液循环的作用
柠檬醛：抑菌、防腐作用。
冰片：善散气、散血、散火、散滞、通窍、逐邪气，能透骨除热，对于风毒入骨、牙痛、痔疮、目赤肿痛、喉痹口疮、溃后不敛有一定功效。
治疗效果举例：
1、顾××，女，53岁，1985年8月因身体不适去医院，医生检查后确认为腰椎间盘突出及颈椎病。直到2014年6月，病症都没有完全治好，而且双手还出现了麻的症状。2014年6月20日上午开始用实施例1的制剂，在患处每天涂抹2次，7天后疼痛基本消失，20天后不适症状完全消失，再涂1周后停止涂用。到目前为止已近一年，未复发。注：使用试剂为第一周2次/天，之后1－2次/天。
2、徐××，男，58岁，2008年8月因身体不适去医院(嘉兴武警医院)，经检查后确认为腰椎间盘突出及颈椎病，但此病症一直都没有完全治疗好。直到2014年4月18日下午开始用实例1的制剂，在患处每天涂抹3次，7天后疼痛基本消失，10天后疼痛完全消失，再涂1周后停止涂用。到目前为止有一年，未复发。
3、徐××，女，49岁，患腰间盘突出2月，用实施例1的制剂每天涂抹患处1次，涂7天后症状完全消失，再涂1周后停止涂用。到目前为止已有8个月，未见复发。
4、朱××，女，43岁，患腰间盘突出6个月，用实施例1的制剂每天 涂抹患处1次，涂7天后症状完全消失，再涂1周后停止涂用。到目前为止已有7个月，未见复发。
5、顾××，女，53岁，患腰间盘突出2年，用实施例1的制剂每天涂抹患处1次，涂20天后症状完全消失，再涂1周后停止涂用。到目前为止已有一年，未见复发。
6、徐××，女，63岁，患腰间盘突出4年，用实施例1的制剂每天涂抹患处1次，涂20天后症状完全消失，再涂2周后停止涂用。到目前为止已有一年，未见复发。
7、蒋××，男，58岁，患腰间盘突出5年，用实施例1的制剂每天涂抹患处1次，涂20天后症状完全消失，再涂2周后停止涂用。到目前为止已有7个月，未见复发。
8、牟××，女，34岁，患腰间盘突出2个月，用实施例1的制剂涂抹患处1次，涂1天后症状完全消失，再涂1周后停止涂用。到目前为止已有8个月，未见复发。
9、徐××，男，58岁，患腰间盘突出3年，用实施例1的制剂每天涂抹患处1次，涂10天后症状完全消失，再涂1周后停止涂用。到目前为止已有一年，未见复发。
10、闻×，男，32岁，患腰间盘突出3个月，用实施例2的制剂每天涂抹患处1次，涂2天后症状完全消失，再涂1周后停止涂用。到目前为止已有8个月，未见复发。
11、吴××，女，35岁，患腰间盘突出1年，用实施例2的制剂每天涂抹患处1次，涂15天后症状完全消失，再涂1周后停止涂用。到目前为止已有一年，未见复发。
12、马××，男，48岁，患腰间盘突出5年，用实施例2的制剂每天涂 抹患处1次，涂30天后症状完全消失，再涂1周后停止涂用。到目前为止已有一年，未见复发。
13、曹××(男)42岁，患腰间盘突出5年，用实施例2的制剂每天涂抹患处1次，涂10天后症状完全消失，再涂1周后停止涂用。到目前为止已有一年，未见复发。
14、曹××，男，51岁，患腰间盘突出3年，用实施例2的制剂每天涂抹患处1次，涂7天后症状完全消失，再涂1周后停止涂用。到目前为止已有一年，未见复发。
15、徐×，女，65，患腰间盘突出5年，用实施例2的制剂每天涂抹患处1次，涂20天后症状完全消失，再涂10天后停止涂用。到目前为止已有一年二个月，未见复发。
16、张××，男，52岁，患腰间盘突出8年(曾在一年六个月前在医院开过刀)用实施例2的制剂每天涂抹患处3次，涂7天后症状完全消失，再涂10天后停止涂用。到目前为止已有一年，未见复发。
17、张××，女，52岁，患腰间盘突出一年六个月，用实施例2的制剂每天涂抹患处1次，涂10天后症状完全消失，再涂1周后停止涂用。到目前为止已有一年，未见复发。
18、缪××，男，53岁，患腰间盘突出一年，用实施例3的制剂每天涂抹患处1次，涂7天后症状完全消失，再涂1周后停止涂用。到目前为止已有一年，未见复发。
19、王××，男，53岁，患腰间盘突出一年，用实施例3的制剂每天涂抹患处1次，涂7天后症状完全消失，再涂1周后停止涂用。到目前为止已有7个月，未见复发。
20、沈××(女)56岁，患腰间盘突出一年，用实施例3的制剂每 天涂抹患处1次，涂10天后症状完全消失，再涂1周后停止涂用。到目前为止已有8个月，未见复发。
21、王××，女，45岁，江苏南通，2015年6月患急性腰椎间盘突出并且十分酸痛，第三天用实施例5的制剂涂2次后症状消失。到目前为止没有复发。
22、王××，男，65岁，江苏南通，2015年6月患急性腰椎间盘突出且十分酸痛，同时脚也麻酸痛，用实施例5的制剂每天涂抹患处2次，3天后到目前为止没有复发。
23、劳××，女，45岁，浙江嘉兴，患腰椎间盘突出曾在医院开刀治疗已有7年，复发后酸痛难耐，她到处就医没有明显的效果。2015年5月使用实施例4制剂每天涂抹患处1次，坚持到2015年9月已经完全康复，到目前为止没有复发过。
24、劳××，女，42岁，浙江嘉兴，患腰椎间盘突出已有2-3年，2015年5月使用实施例4制剂每天涂抹患处1次，1个月后，身体恢复健康，至今未见复发。
25、张××，男，45岁，浙江嘉兴，患腰椎间盘突出且骨头已经变形，2014年8月使用实施例6制剂每天涂抹患处1次，4个月后，身体完全恢复，至今没有复发过。
26、陈××，男，55岁，浙江嘉兴，患腰椎间盘突出已有5-6年，2015年4月使用实施例4制剂每天涂抹患处1次，一个月后，身体完全恢复，至今未复发过。
27、张××，男62岁，浙江嘉兴，患腰椎间盘突出已有10年，2015年4月开始使用实施例4制剂每天涂抹患处1次，4个月后恢复健康且至今未复发。
28、王××，男，32岁，浙江嘉兴，患腰椎间盘突出，2015年9月 使用实施例5制剂每天涂抹患处1次，1个月后恢复，至今未复发。
29、封××，男，45岁，浙江嘉兴，患腰椎间盘突出，2015年7使用实施例5制剂每天涂抹患处1次，2个月后恢复健康，至今未复发过。
30、俞××，女，40岁，浙江嘉兴，患腰椎间盘突出，2015年7月使用实施例5制剂每天涂抹患处1次，1个月后恢复健康，至今未复发过。
31封××，女，42岁，浙江嘉兴，患腰椎间盘突出，2015年7月使用实施例5制剂每天涂抹患处1次，1个月后完全恢复正常，至今未见复发。
32、缪××，女，38岁，浙江嘉兴，患腰椎间盘突出，2014年9月使用实施例6制剂每天涂抹患处1次，5个月后完全恢复正常，至今未见复发。
33王××，男，28岁，浙江嘉兴，患腰椎间盘突出曾在医院开刀治疗，两年半后复发，2014年10月使用实施例6制剂每天涂抹患处1次，2天后完全恢复正常，至今未见复发。
34、胡××，男52岁，浙江嘉兴，患腰椎间盘突出，2015年6月使用实施例5制剂每天涂抹患处1次，1个月后恢复正常，至今未见复发。
35、曹××，男48岁，浙江嘉兴，患腰椎间盘突出且睡前和开车时都非常酸痛，曾在富阳骨科医院嘉兴武警医院就医治疗，被告知不能医治好。2014年7月使用实施例6制剂每天涂抹患处1次，3个月后恢复正常，至今未见复发。
36、夏××，女，28岁，贵州，患腰椎间盘突出且非常酸痛影响正常工作，2015年9月使用实施例5制剂每天涂抹患处1次，2天后完全恢复正常，至今未见复发。
37、李××，女，35岁，贵州，患腰椎间盘突出，身体酸痛难受，2015年8月使用实施例5制剂每天涂抹患处1次，2天后完全恢复正常， 至今未见复发。
38、李××，女，34岁，贵州，患腰椎间盘突出，身体十分酸痛已经不能正常工作，2015年8月使用实施例5制剂每天涂抹患处1次，1天后恢复正常，至今未见复发。
39、王××，男，52，岁，浙江嘉兴，患腰椎间盘突出曾在嘉兴武警医院开刀治疗，两年半后复发，2014年8月使用实施例6每天涂抹患处1次，制剂3天后完全恢复正常，至今已有18个月未见复发。
40缪××，女，54岁，浙江嘉兴，患颈椎病且双手已麻，2015年3月使用实施例4制剂每天涂抹患处1次，1个月后完全恢复，至今未见复发。
41、缪××，女，52岁，浙江嘉兴，患腰椎间盘突出，2015年1月使用实施例4制剂每天涂抹患处1次，15天后完全康复，至今未见复发。
42、吴××，女，65岁，浙江嘉兴，35岁时患腰椎间盘突出一直未好，2015年3月使用实施例4制剂每天涂抹患处1次，5个月后完全恢复，至今未见复发。
43、俞××，女，45岁，浙江嘉兴，患腰椎间盘突出，2015年6月使用实施例5制剂每天涂抹患处1次，15天后恢复正常，至今未见复发。
44、倪××，男，48岁，浙江嘉兴，患腰椎间盘突出，2015年6月使用实施例5制剂每天涂抹患处1次，30天后恢复正常，至今未见复发。
45、吴××，女，51岁，浙江嘉兴，患腰椎间盘突出，2014年8月开始使用实施例6每天涂抹患处1次，制剂5个月后恢复健康，至今未见复发。
56、朱××，男，60岁，山东菏泽，患腰椎间盘突出已有5年，2015年4月开始使用实施例4制剂每天涂抹患处1次，3个月后完全恢复正常，至今未见复发。
57、王××，男，30岁，山东菏泽，患颈椎病已有5个月并且双手麻，使用实施例6制剂每天涂抹患处1次，2个月后恢复健康，至今未见复发。
58、姚××，男，50岁，山东菏泽，患腰椎间盘突出已有10年，2015年4月开始使用实施例4制剂每天涂抹患处1次，1个月后完全恢复健康，至今未见复发。
59、姚××，男，80岁，山东菏泽，患腰椎间盘突出已有50年，2015年4月使用实施例4制剂每天涂抹患处1次，6个月后完全康复，至今未见复发。
60、曹××，女，50岁，山东菏泽，患腰椎间盘突出已有10年，2015年4月使用实施例4制剂每天涂抹患处1次，4个月后完全恢复健康，至今未见复发。
61、俞××，女，35岁，山东菏泽，患腰椎间盘突出已有1年，2015年5月使用实施例4制剂每天涂抹患处1次，7天后完全恢复健康，至今未见复发。
62、李××，男，52岁，安徽，患腰椎间盘突出，2015年6月使用实施例5制剂每天涂抹患处1次，15天后恢复健康，至今未见复发。
63、陆××，女，42岁，浙江嘉兴，患腰椎间盘突出，2015年6月使用实施例5制剂每天涂抹患处1次，2个月后恢复健康，至今未见复发。
64、贺××，女，45岁，河南濮阳，患腰椎间盘突出，2015年7月使用实施例5制剂每天涂抹患处1次，15天后恢复健康，至今未见复发。
65、贺××，男，67岁，河南濮阳，患腰椎间盘突出，2015年7月使用实施例5制剂每天涂抹患处1次，1个月后恢复健康，至今未见复发。
66、林××，女，80岁，浙江宁海，患腰椎间盘突出多年，经医院诊断为：腰椎第三节压迫神经引起右脚无法直立自由行走，2014年8月 使用实施例6制剂每天涂抹患处1次，1个月后能下床走动，继续使用15天后完全恢复健康，至今未见复发。
67、赵××，男，37岁，浙江嘉兴，患腰椎间盘突出5年，2015年3月使用实施例4制剂每天涂抹患处1次后，2个月完全康复，至今没有复发。
68、赵××，男，40岁，浙江嘉兴，患腰椎间盘突出曾在医院开刀治疗，一年后病情又出现复发，2015年3月使用实施例4制剂每天涂抹患处1次，2个月后完全康复，至今未见复发。
69、俞××，男，32岁，浙江临安，患腰椎间盘突出，2015年4月使用实施例4制剂每天涂抹患处1次，2个月已经完全康复，至今未见复发。
70、邵××，男，60岁，浙江海宁，患腰椎间盘突出5年，2014年9月使用实施例6制剂每天涂抹患处1次，2个月已经完全康复，至今未见复发。
71、莫××，女，82岁，江苏南通，腰椎间盘突出，2014年9月使用实施例6制剂每天涂抹患处1次，1个月已经完全康复，至今未见复发。

Claims (8)

  1. 一种外用药物制剂，其特征在于所述的药物制剂是在每1000g发酵液中加入如下成分制得：
    丁香罗勒油  7－8ml，
    水杨酸甲酯  4－5ml，
    姜樟油  0.10－0.15g，
    肉桂油  0.2－0.3g，
    桂皮醛  0.2－0.3g，
    柠檬醛  0.005－0.01g，
    冰片  0.02－0.04g
    所述的发酵液按如下方法制得：辣椒与醋酸水溶液混匀后于15℃－20℃温度条件下发酵7－9天后过滤取滤液得发酵液，所述的醋酸水溶液中乙酸重量含量为7％－9％，所述的辣椒以干辣椒重量计加入量为1.6－2.5g/10g醋酸水溶液。
  2. 如权利要求1所述的外用药物制剂，其特征在于所述的辣椒为辣椒碎片。
  3. 如权利要求1所述的外用药物制剂，其特征在于所述的辣椒为干的辣椒碎片。
  4. 如权利要求1－3之一所述的外用药物制剂，其特征在于所述的药物制剂是在每1000g发酵液中加入如下成分制得：
    丁香罗勒油  7.2－7.5ml，
    水杨酸甲酯  4－5ml，
    姜樟油  0.12－0.15g，
    肉桂油  0.25－0.28g，
    桂皮醛  0.25－0.28g，
    柠檬醛  0.006－0.01g，
    冰片  0.02－0.04g
    所述的发酵液按如下方法制得：辣椒与醋酸水溶液混匀后于18℃－20℃温度条件下发酵7－9天后过滤取滤液得发酵液，所述的醋酸水溶液中乙酸重量含量为7％－9％，所述的辣椒以干辣椒重量计加入量为2－2.3g/10g醋酸水溶液。
  5. 如权利要求4所述的外用药物制剂，其特征在于所述的发酵液按如下方法制得：辣椒与醋酸水溶液混匀后于18℃－20℃温度条件下发酵7－8天后过滤取滤液得发酵液，所述的醋酸水溶液中乙酸重量含量为7％－9％，所述的辣椒以干辣椒重量计加入量为2－2.15g/10g醋酸水溶液。
  6. 如权利要求1所述的外用药物制剂的制备方法，其特征在于所述的方法按如下步骤进行：
    (1)液体A的配制：将碎辣椒与醋酸水溶液混匀后于15℃－20℃温度条件下发酵7－9天后过滤取滤液得发酵液即液体A，所述的醋酸水溶液中乙酸重量含量为7％－9％，所述的辣椒以干辣椒重量计加入量为1.6－2.5g/10g醋酸水溶液。
    (2)按每1000g发酵液加入如下剂量的成份：丁香罗勒油7－8ml，水杨酸甲酯4－5ml，姜樟油0.10－0.15g，肉桂油0.2－0.3g，桂皮醛0.2－0.3g，柠檬醛0.005－0.01g，冰片0.02－0.04g；搅拌充分全部溶化即得外用药物制剂。
  7. 如权利要求1所述的外用药物制剂在制备治疗腰间盘突出药物中的应用。
  8. 如权利要求1所述的应用，所述的外用药物制剂为用于直接涂沫于腰间盘突出的患处。
PCT/CN2016/078739 2015-05-08 2016-04-07 一种外用制剂及其在制备治疗腰间盘突出药物中的应用 WO2016180119A1 (zh)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110051541A (zh) * 2019-06-06 2019-07-26 四川涑爽医疗用品有限公司 一种氢氧化钙根管消毒糊剂及其制备方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104887755A (zh) * 2015-05-08 2015-09-09 寿根其 治疗腰间盘突出的制剂的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1806823A (zh) * 2005-01-21 2006-07-26 北京东方凯恩医药科技有限公司 一种外用驱风的中药组合物贴膏
CN104887755A (zh) * 2015-05-08 2015-09-09 寿根其 治疗腰间盘突出的制剂的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1368138A (zh) * 2001-02-02 2002-09-11 杨孟君 纳米红花制剂药物及其制备方法
CN101314023A (zh) * 2008-07-15 2008-12-03 李爱军 一种治疗腰椎间盘突出症的药物
CN104491767A (zh) * 2014-08-18 2015-04-08 李学尧 一种用于缓解疼痛的中药组合物及其制备方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1806823A (zh) * 2005-01-21 2006-07-26 北京东方凯恩医药科技有限公司 一种外用驱风的中药组合物贴膏
CN104887755A (zh) * 2015-05-08 2015-09-09 寿根其 治疗腰间盘突出的制剂的制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ZHANG, LIQIAN ET AL.: "Study on the Extraction of Capsaicin with Acetic Acid and Microwave-pretreatment", FOOD RESEARCH AND DEVELOPMENT, vol. 29, no. 3, 31 March 2008 (2008-03-31), pages 66 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110051541A (zh) * 2019-06-06 2019-07-26 四川涑爽医疗用品有限公司 一种氢氧化钙根管消毒糊剂及其制备方法

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